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Neonatal rct

Karan Arora, Sorabh Goel, Swati Manerkar, Nimisha Konde, Harshad Panchal, Deeparaj Hegde, Jayashree Mondkar
OBJECTIVE: To determine effect of Premature Infant Oral Motor Intervention program on oro-motor function and time to full independent wati spoon feeds in preterm infants. METHODS: 30 preterm infants between 28-32 weeks of gestation on full gavage feeds of 150 mL/kg/day were randomized to receive either pre-feed oro-motor stimulation using Premature Infant Oral Motor Intervention (structured stimulation) or sham intervention (unstructured stimulation). RESULTS: Improvement in mean (SD) Neonatal Oro-Motor Assessment Scale (NOMAS) over 7 days from baseline was significantly higher in the study group infants as compared to control group (9...
August 15, 2018: Indian Pediatrics
Jiamin Wang, Shankun Zhao, Lianmin Luo, Yangzhou Liu, Zhiguo Zhu, Ermao Li, ZhiGang Zhao
OBJECTIVE: To compare dorsal penile nerve block (DPNB) and eutectic mixture of local anesthetics (EMLA) cream for pain relief in infants during circumcision. METHODS: We systematically searched Medline via PubMed, Embase, CNKI and the Cochrane Library Center Register to identify randomized controlled trials up to March 2018. Effect estimates were performed in random effect models. Mean neonate infant pain scale (NIPS) scores, incidence of hematoma, edema and erythema, mean heart rate were conducted to assessed the effect of analgesia...
2018: PloS One
Ridhimaa Jain, Ashish Jain, Veena Devgan, Jerin Sekhar
OBJECTIVE: To determine the effect of alternative positions (relative to placenta) of normal term neonates, prior to the recommended delayed cord clamping, on placental transfusion and short-term neonatal outcome. METHODS: Normal term neonates born vaginally were randomly assigned to be placed either on mother's abdomen (Group AL, n = 97) or 20 cm below the introitus (Group BL, n = 102) for 90 seconds after delivery. Subsequently the cord was clamped. Outcome measures were anthropometry, hematological profile including ferritin at birth and at 3-4 months; and adverse effects, polycythemia and jaundice...
September 5, 2018: Journal of Maternal-fetal & Neonatal Medicine
Peter J Anderson, Katherine J Lee, Gehan Roberts, Megan M Spencer-Smith, Deanne K Thompson, Marc L Seal, Chiara Nosarti, Andrea Grehan, Elisha K Josev, Susan Gathercole, Lex W Doyle, Leona Pascoe
OBJECTIVE: To assess the effectiveness of Cogmed Working Memory Training compared with a placebo program in improving academic functioning 24 months post-training in extremely preterm/extremely low birth weight 7-year-olds. STUDY DESIGN: A multicenter double-blind, placebo-controlled randomized controlled trial was conducted across all tertiary neonatal hospitals in the state of Victoria, Australia. Participants were 91 extremely preterm/extremely low birth weight 7-year-old children born in Victoria in 2005...
August 31, 2018: Journal of Pediatrics
Fatemeh Jahanjoo, Azizeh Farshbaf-Khalili, Seyed Kazem Shakouri, Neda Dolatkhah
INTRODUCTION: Many scientists have revealed the association between vitamin D deficiency and gestational diabetes mellitus (GDM). The purpose of this review was to evaluate the impact of vitamin D supplementation on maternal and neonatal health measures in GDM. METHODS: A comprehensive systematic literature search in the electronic databases including Cochrane Central Register of Controlled Trials, MEDLINE (PubMed), Scopus, Web of Sciences, EMBASE, Google Scholar, Clininaltrial...
2018: Annals of Nutrition & Metabolism
Shalin Lee Wan Fei, Keng Sheng Chew, Saloma Pawi, Li Tsu Chong, Khatijah Lim Abdullah, Lik Thai Lim, Feryante Rintika
OBJECTIVE: To identify the efficacy and safety of the use of various cost-effective reflective materials around phototherapy units to reduce the duration of phototherapy and hasten the reduction of bilirubin among neonates with physiologic jaundice. DATA SOURCES: A systematic review of randomized controlled trials identified from searches in the Cumulative Index to Nursing and Allied Health Literature, ScienceDirect, Embase, and the Cochrane Library with the use of keywords, MeSH terms, operators, and the review of reference lists of retrieved articles...
August 30, 2018: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
Wenneke van Weelden, Vincent Wekker, Leon de Wit, Jacqueline Limpens, Hilkka Ijäs, Aleid G van Wassenaer-Leemhuis, Tessa J Roseboom, Bas B van Rijn, J Hans DeVries, Rebecca C Painter
INTRODUCTION: Antidiabetic drugs (OADs) are increasingly prescribed to treat hyperglycaemia during pregnancy in women with gestational diabetes mellitus (GDM) or polycystic ovary syndrome (PCOS), even though long-term effects on offspring are unknown. This systematic review summarises the evidence of follow-up studies of randomised controlled trials (RCTs) reporting on long-term effects of prenatal exposure to OADs on offspring. METHODS: The MEDLINE, EMBASE and CENTRAL databases were searched from inception to April 2018 for the concepts antidiabetic agents and prenatal exposure (or pregnancy and offspring/child) in combination with an RCT search filter...
August 30, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Nobuhiko Nagano, Makoto Saito, Takahiro Sugiura, Fumiko Miyahara, Fumihiko Namba, Erika Ota
BACKGROUND: Optimum timing of umbilical cord clamping has not been established in preterm infants. OBJECTIVES: We compared the short- and long-term effects of umbilical cord milking (UCM) versus delayed cord clamping (DCC) on infants born at less than 37 weeks of gestation. SEARCH METHODS: A systematic review and meta-analysis was conducted according to the "Preferred Reporting Items for Systematic Reviews and Meta-Analyses" statement...
2018: PloS One
V R Viraraghavan, Sushma Nangia, B H Prathik, Babu S Madarkar, Deepshika Rani, Arvind Saili
BACKGROUND: Delivery room management of infants born via meconium-stained amniotic fluid (MSAF) is quite controversial. No study has tried to quantify the amount of meconium that can be aspirated from the trachea of a non-vigorous neonate born through MSAF. AIMS: To study the yield of meconium in non-vigorous neonates born through MSAF undergoing endotracheal (ET) suctioning. METHODS: This was a prospective observational study conducted from 1 March 2015 to 31 October 2015...
August 30, 2018: Paediatrics and International Child Health
Maryam Saboute, Ali Mazouri, Fatemeh NaimiDehnavi, Nasrin Khalesi, Zahra Farahani
Background: Feeding intolerance is a common complication in preterm neonates and is responsible for prolonged hospitalization. This study aimed at assessing the effects of high-dose oral erythromycin on feeding intolerance in preterm infants. Methods: A randomized, double blinded, placebo-controlled trial was performed during 2014 and 2015 (Tehran-Iran). Preterm neonates aged >14 days, who met the feeding intolerance criteria were selected for the study and their medical records were randomly assigned into 2 groups by simple randomization...
2018: Medical Journal of the Islamic Republic of Iran
Joseph M Zulu, Isabel Goicolea, John Kinsman, Ingvild Fossgard Sandøy, Astrid Blystad, Chama Mulubwa, Mpundu C Makasa, Charles Michelo, Patrick Musonda, Anna-Karin Hurtig
BACKGROUND: Research that explores how community-based interventions for strengthening adolescent sexual reproductive health and rights (SRHR) can be integrated and sustained in community health systems, is, to the best of our knowledge, very scarce, if not absent. It is important to document mechanisms that shape integration process in order to improve health systems' responsiveness towards adolescents' SRHR. This realist evaluation protocol will contribute to this knowledge in Zambia where there is increased attention towards promoting maternal, neonatal and child health as a means of addressing the current high early pregnancy and marriage rates...
August 28, 2018: Reproductive Health
S K Yadav, K Venkatnarayan, K M Adhikari, R Sinha, S S Mathai
OBJECTIVE: To evaluate the efficacy of gastric lavage (GL) in preventing feed intolerance in babies born through Meconium stained amniotic fluid (MSAF). STUDY DESIGN: In this randomized trial conducted at a tertiary care hospital, neonates born of MSAF after 34 weeks period of gestation requiring routine care were randomly allocated to GL with 10 ml/kg of normal saline. The control group did not receive GL. The subjects were monitored for first 24 hours in predefined time epochs...
August 22, 2018: Journal of Neonatal-perinatal Medicine
Isil Uzun Cilingir, Cenk Sayin, Havva Sutcu, Cihan İnan, Selen Erzincan, Cem Yener, Fusun Varol
PURPOSE: Cervical cerclage treatment for cervical changes at mid trimester is a very controversial topic in twins. The aim of the study was to present our maternal and fetal outcomes of mid-trimester cervical cerclage in twin pregnancies. BASIC PROCEDURES: This study was performed using data extracted from the medical files of the twin pregnancies whom performed emergency cervical cerclage between January 2012 and March 2018 at Trakya University, Facuty of Medicine, Department of Perinatology...
August 23, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Emma A Amissah, Julie Brown, Jane E Harding
BACKGROUND: Preterm infants are born with low glycogen stores and require higher glucose intake to match fetal accretion rates. In spite of the myriad benefits of breast milk for preterm infants, it may not adequately meet the needs of these rapidly growing infants. Supplementing human milk with carbohydrates may help. However, there is a paucity of data on assessment of benefits or harms of carbohydrate supplementation of human milk to promote growth in preterm infants. This is a 2018 update of a Cochrane Review first published in 1999...
August 23, 2018: Cochrane Database of Systematic Reviews
Anthony M Vintzileos
In this issue of the BJOG, Smith et al report a randomized controlled trial of a 20-minute admission cardiotocography (ACTG) versus intermittent auscultation (IA) in low-risk pregnancies (Smith et al BJOG; 2018:XXXX). There were no differences in maternal or neonatal outcomes other than more frequent use of continuous CTG (cCTG) in the ACTG group. The authors concluded that further research is needed comparing IA and ACTG before the diagnosis of labor. This article is protected by copyright. All rights reserved...
August 21, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
A R Araujo da Silva, A F Marques, C Biscaia di Biase, W Zingg, A Dramowski, M Sharland
INTRODUCTION: Few data are available to inform strategies for the prevention of catheter-associated urinary tract infection (CAUTI) in children and neonates. Many recommendations are derived from studies in adults and cannot be applied to the paediatric population. OBJECTIVE: This study was aimed to identify all studies that measured the efficacy of an intervention for the prevention of CAUTI in children and neonates. METHODS: A systematic review using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) was conducted...
July 21, 2018: Journal of Pediatric Urology
Sonia Minooee, Allison Cummins, Maralyn Foureur
OBJECTIVE: Shoulder dystocia (SD) is an obstetric emergency which if not carefully diagnosed and managed, can contribute to lifelong neonatal morbidities. Despite current guidelines on the definition of SD (impaction of the fetal shoulder behind the maternal symphysis pubis and need for ancillary manoeuvres or head-body delivery interval (HBDI) >60 s) its accurate diagnosis requires clinical expertise as well as overall consideration of feto-maternal condition. Based on the literature available, our study aims to determine (1) the range of HBDI as an indicator of SD and (2) the neonatal complications occurring following prolonged HBDI in normal or SD-complicated births...
August 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Barbara Prediger, Stephanie Polus, Tim Mathes, Stefanie Bühn, Frank Louwen, Edmund A M Neugebauer, Dawid Pieper
BACKGROUND: The rate of caesarean sections increased in the last decades to about 30% of births in western populations. Many caesarean sections are electively planned without an urgent medical reason for mother or child. Especially in women with a foregoing caesarean section, the procedure is planned early. An early caesarean section though may harm the newborn. Our aim is to evaluate the gestational time point after the 37th gestational week (after prematurity = term) of performing an elective caesarean section with the lowest morbidity for mother and child...
August 16, 2018: Systematic Reviews
Maliwan Oofuvong, Thitikan Kunapaisal, Orarat Karnjanawanichkul, Nussara Dilokrattanaphijit, Jaranya Leeratiwong
BACKGROUND: The weight-based dosing of ondansetron to reduce hypotension has never been investigated. The aim of this study is to determine the optimal dose of ondansetron required based on the patient's weight to reduce hypotension following spinal anesthesia for cesarean section. METHODS: In this prospective, triple-blinded, parallel group, randomized controlled trial, a total of 228 pregnant women were randomized to receive either normal saline (group NS) or ondansetron 0...
August 15, 2018: BMC Anesthesiology
Xiu-Min Jiang, Qi-Yan Chen, Sheng-Bin Guo, Li-Zhu Jin, Xin-Xin Huang, Xiu-Wu Liu, Jin-Xiu Hong, Hai-Bin Qu, Rong-Fang Hu
BACKGROUND: The high caesarean section rate is a prominent public health problem in China. AIM: This study aimed to determine the effects of midwife-led care during labour on birth outcomes for healthy primiparas. DESIGN: Randomized controlled trial. SETTING: The Obstetrics Department of Fujian Provincial Maternity and Child Health Hospital. METHODS: A total of 666 primiparas in labour were randomly divided into an intervention and control group (333 in each group)...
August 14, 2018: International Journal of Nursing Practice
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