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Neonatal rct

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https://www.readbyqxmd.com/read/29138031/mortality-and-pulmonary-outcomes-of-extremely-preterm-infants-exposed-to-antenatal-corticosteroids
#1
Colm P Travers, Waldemar A Carlo, Scott A Mcdonald, Abhik Das, Edward F Bell, Namasivayam Ambalavanan, Alan H Jobe, Ronald N Goldberg, Carl T D'Angio, Barbara J Stoll, Seetha Shankaran, Abbot R Laptook, Barbara Schmidt, Michele C Walsh, Pablo J Sanchez, M Bethany Ball, Ellen C Hale, Nancy S Newman, Rosemary D Higgins
BACKGROUND: Antenatal corticosteroids are given primarily to induce fetal lung maturation but results from meta-analyses of randomized controlled trials have not shown mortality or pulmonary benefits for extremely preterm infants although these are the infants most at risk of mortality and pulmonary disease. OBJECTIVE: To determine if exposure to antenatal corticosteroids is associated with a lower rate of death and pulmonary morbidities by 36 weeks' postmenstrual age...
November 11, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29137502/innovative-product-development-partnership-reduced-neonatal-mortality-in-nepal-through-improved-umbilical-cord-care
#2
Peter Oyloe, Leela Khanal, Stephen Hodgins, Sabita T Pradhan, Penny Dawson
Approximately 40 percent of all newborn deaths in Nepal are attributable to neonatal infections. A randomized controlled trial conducted in Nepal in the period 2002-05 on the application of a solution of the disinfectant chlorhexidine to umbilical cord stumps of newborns showed a reduced risk of infections and death. In response to these results, the Government of Nepal and various partners mobilized to deliver this simple, low-cost intervention on a national scale. We describe the design, development, and maturation of a partnership among the government, technical assistance agencies, and a local pharmaceutical company to create a suitable, commercially available gel product to reduce newborn infections...
November 2017: Health Affairs
https://www.readbyqxmd.com/read/29132733/enhanced-nutrient-supply-to-very-low-birth-weight-infants-is-associated-with-higher-blood-amino-acid-concentrations-and-improved-growth
#3
Kenneth Strømmen, Alexander Haag, Sissel J Moltu, Marit B Veierød, Elin W Blakstad, Britt Nakstad, Astrid N Almaas, Kristin Brække, Arild E Rønnestad, Hannelore Daniel, Christian A Drevon, Per O Iversen
BACKGROUND & AIMS: Customized nutrient supply is vital to ensure optimal growth among very low birth weight infants (birth weight < 1500 g). The supply of amino acids is especially important due to their impact on protein synthesis and growth. The objectives of this study were to evaluate the impact of enhanced nutrition on growth, blood concentrations of amino acids, and explore possible associations between amino acid concentrations and common neonatal morbidities. We hypothesized higher amino acids levels and growth velocity among infants on enhanced nutrient supply...
April 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29131740/the-impact-of-prenatal-yoga-on-exercise-attitudes-and-behavior-teachable-moments-from-a-randomized-controlled-trial
#4
Shilpa Babbar, Blake W Porter, Karen B Williams
OBJECTIVE: Pregnancy serves as an opportune time for "teachable moments" to elicit positive behavior change. We evaluated change in exercise perception, behavior and gestational weight gain in participants engaged in a one-hour educational experience. METHODS: Women between 28 0/7 to 36 6/7 weeks with no prior yoga experience carrying a non-anomalous singleton fetus participated in a randomized controlled trial on prenatal yoga. The yoga group engaged in a one-hour yoga class; the attention control educational group, in a one-hour presentation on exercise, nutrition and obesity in pregnancy...
November 2017: International Journal of Yoga Therapy
https://www.readbyqxmd.com/read/29129039/combined-diet-and-exercise-interventions-for-preventing-gestational-diabetes-mellitus
#5
REVIEW
Emily Shepherd, Judith C Gomersall, Joanna Tieu, Shanshan Han, Caroline A Crowther, Philippa Middleton
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with a wide range of adverse health consequences for women and their infants in the short and long term. With an increasing prevalence of GDM worldwide, there is an urgent need to assess strategies for GDM prevention, such as combined diet and exercise interventions. This is an update of a Cochrane review that was first published in 2015. OBJECTIVES: To assess the effects of diet interventions in combination with exercise interventions for pregnant women for preventing GDM, and associated adverse health consequences for the mother and her infant/child...
November 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29125893/mesenchymal-stem-cells-for-the-prevention-and-treatment-of-bronchopulmonary-dysplasia-in-preterm-infants
#6
REVIEW
Maria Pierro, Bernard Thébaud, Roger Soll
BACKGROUND: Bronchopulmonary dysplasia (BPD) remains a major complication of prematurity and currently lacks efficient treatments. Mesenchymal stem/stromal cells (MSCs) have been extensively explored as a potential therapy in several preclinical and clinical settings. Human and animal MSCs have been shown to prevent and treat lung injury in various preclinical models of lung diseases, including experimental BPD. OBJECTIVES: To determine if MSCs, administered intravenously or endotracheally, are safe and effective in preventing or treating BPD, or both, in preterm infants...
November 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29123341/effect-of-expressed-breast-milk-versus-swaddling-versus-oral-sucrose-administration-on-pain-associated-with-suctioning-in-preterm-neonates-on-assisted-ventilation-a-randomized-controlled-trial
#7
Saumil Desai, Ruchi Nimish Nanavati, Rohit Nathani, Nandkishor Kabra
Objective: The objective of our study was to assess the pain associated with suctioning in preterm neonates on assisted ventilation and comparing the use of expressed breast milk (EBM), sucrose, and swaddling to alleviate pain. Methods: Study design: A randomized controlled clinical trial. Inclusion Criteria: Preterm neonates on assisted ventilation. Exclusion Criteria: Major congenital anomalies and severe encephalopathy...
October 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29113376/efficacy-of-glucocorticoids-vitamin-a-and-caffeine-therapies-for-neonatal-mortality-in-preterm-infants-a-network-meta-analysis
#8
Ying Li, Jie Gao, Qiwei Wang, Xiaojian Ma
Introduction: The paper aimed to evaluate the efficacy of different therapies in improving survival among preterm infants. Materials and Methods: PubMed and Embase were searched from inception to 2017. We assessed studies for eligibility and extracted data. A Bayesian random-effects model was used to evaluate different therapies combined direct comparisons with indirect evidence. Consistency analysis was achieved using node-splitting plots. Surface under the cumulative ranking curve (SUCRA) was calculated to rank different therapies...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29103346/efficacy-of-zinc-supplementation-for-neonatal-sepsis-a-systematic-review-and-meta-analysis
#9
Zhijun Tang, Zonghui Wei, Fei Wen, Yongdei Wu
BACKGROUND: Zinc supplementation has some potential in treating neonatal sepsis. We conduct a systematic review and meta-analysis to explore the efficacy of zinc supplementation for neonatal sepsis. METHODS: PubMed, Embase, Web of science, EBSCO, and Cochrane Library databases are systematically searched. Randomized controlled trials (RCTs) assessing the efficacy of zinc supplementation in neonatal sepsis are included. Two investigators independently search articles, extract the data, and assessed the quality of included studies...
November 5, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29101776/the-effects-of-massage-by-mothers-on-mother-infant-attachment
#10
Mahnaz Shoghi, Soroor Sohrabi, Mahboobe Rasouli
Context • Transferring a newborn to the intensive care unit due to a premature birth is a major obstacle in the establishment of emotional attachment between a mother and her child. Researchers believe that the formation and continuation of such an attachment have a profound effect on the child's mental development and behavior in the coming years of life. Not all studies have agreed, however, that skin contact alone, such as massage provides, can improve attachment. Objective • The aim of this study was to determine the effects on maternal attachment behaviors of infants hospitalized in a neonatal intensive care unit (NICU) of massage provided by mothers for their premature neonates...
November 4, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29101631/effect-of-placental-transfusion-on-iron-stores-in-moderately-preterm-neonates-of-30-33%C3%A2-weeks-gestation
#11
Bikramjit Das, Venkataseshan Sundaram, Praveen Kumar, William T Mordi, Lakhbir K Dhaliwal, Reena Das
OBJECTIVE: To assess the effect of placental transfusion by delayed cord clamping (DCC) of 60 s or cord milking (CM) on serum ferritin levels at hospital discharge and 3 mo of postmenstrual age (PMA) in preterm neonates of 30 to 33 wk gestation in comparison to early cord clamping (ECC) within 10 s. METHODS: This mixed longitudinal study was conducted in moderately preterm neonates of 30 to 33 wk gestation born in a level III unit in Northern India with the study sample nested within a randomized controlled trial on placental transfusion...
November 4, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29100533/effectiveness-of-interventions-during-nicu-hospitalization-on-the-neurodevelopment-of-preterm-infants-a-systematic-review-protocol
#12
Marilyn Aita, Robyn Stremler, Nancy Feeley, Andréane Lavallée, Gwenaëlle De Clifford-Faugère
BACKGROUND: Previous systematic reviews have examined preterm infants' long-term neurodevelopment after neonatal intensive care unit (NICU) discharge, although none have explored the effectiveness of interventions on preterm infants' neurodevelopment during NICU hospitalization. The aim of this review is to evaluate whether interventions, i.e., sensory stimulation, parental involvement, and control of environment, improve preterm infants' neurodevelopment during their NICU hospitalization...
November 3, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29100198/non-nutritive-sucking-oral-breast-milk-and-facilitated-tucking-relieve-preterm-infant-pain-during-heel-stick-procedures-a-prospective-randomized-controlled-trial
#13
Hsueh-Fang Peng, Ti Yin, Luke Yang, Chi Wang, Yue-Cune Chang, Mei-Jy Jeng, Jen-Jiuan Liaw
BACKGROUND: Preterm infant pain can be relieved by combining non-nutritive sucking (sucking), oral sucrose, and facilitated tucking (tucking), but the pain-relief effects of oral expressed breast milk (breast milk) are ambiguous. AIMS: We compared the effects of combined sucking+ breast milk, sucking+breast milk+tucking, and routine care on preterm infant pain during and after heel-stick procedures. DESIGN: A prospective, randomized controlled trial...
October 8, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29099872/a-pilot-randomized-controlled-trial-of-ekg-for-neonatal-resuscitation
#14
Anup Katheria, Kathy Arnell, Melissa Brown, Kasim Hassen, Mauricio Maldonado, Wade Rich, Neil Finer
BACKGROUND: The seventh edition of the American Academy of Pediatrics Neonatal Resuscitation Program recommends the use of a cardiac monitor in infants that need resuscitation. Previous trials have shown that EKG heart rate is available before pulse rate from a pulse oximeter. To date no trial has looked at how the availability of electrocardiogram (EKG) affects clinical interventions in the delivery room. OBJECTIVE: To determine whether the availability of an EKG heart rate value and tracing to the clinical team has an effect on physiologic measures and related interventions during the stabilization of preterm infants...
2017: PloS One
https://www.readbyqxmd.com/read/29082364/effect-of-metformin-on-maternal-and-neonatal-outcomes-in-pregnant-obese-non-diabetic-women-a-meta-analysis
#15
Ahmed Elmaraezy, Abdelrahman Ibrahim Abushouk, Amany Emara, Omar Elshahat, Hussien Ahmed, Magdy I Mostafa
BACKGROUND: Metformin reduces maternal and neonatal weight gain in gestational diabetes mellitus; however, this effect is poorly investigated in non-diabetic women. OBJECTIVE: We performed this meta-analysis to investigate the effect of metformin intake during pregnancy on maternal and neonatal outcomes in obese non-diabetic women. MATERIALS AND METHODS: We searched Medline, EMBASE, and Cochrane CENTRAL for eligible randomized controlled trials addressing the efficacy of metformin in pregnant obese non-diabetic women...
August 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29082010/prenatal-and-perinatal-risk-factors-for-disability-in-a-rural-nepali-birth-cohort
#16
Edward J N Haworth, Kirti M Tumbahangphe, Anthony Costello, Dharma Manandhar, Dhruba Adhikari, Bharat Budhathoki, Dej Krishna Shrestha, Khadka Sagar, Michelle Heys
BACKGROUND: Improving newborn health remains a global health priority. Little however is known about the neurodevelopmental consequences for survivors of complications in pregnancy, labour and the neonatal period in in low-income countries outside of small selective and typically urban facility studies. We ask which antenatal, birth and neonatal factors are associated with disability in childhood in a large community birth cohort from rural Nepal. METHODS: 6436 infants were recruited during a cluster randomised control trial (RCT) of participatory women's groups (ISRCTN31137309), of whom 6075 survived beyond 28 days...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29081069/different-methods-and-settings-for-glucose-monitoring-for-gestational-diabetes-during-pregnancy
#17
REVIEW
Puvaneswary Raman, Emily Shepherd, Therese Dowswell, Philippa Middleton, Caroline A Crowther
BACKGROUND: Incidence of gestational diabetes mellitus (GDM) is increasing worldwide. Blood glucose monitoring plays a crucial part in maintaining glycaemic control in women with GDM and is generally recommended by healthcare professionals. There are several different methods for monitoring blood glucose which can be carried out in different settings (e.g. at home versus in hospital). OBJECTIVES: The objective of this review is to compare the effects of different methods and settings for glucose monitoring for women with GDM on maternal and fetal, neonatal, child and adult outcomes, and use and costs of health care...
October 29, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29076668/efficacy-of-two-regimens-of-dexamethasone-for-management-of-preterm-labour-pilot-study
#18
Ahsan Rasool, Umer Farooq, Qurat-Ul-Ann Nazir, Hira Bahar Durani
BACKGROUND: Dexamethasone is widely used for prevention of respiratory distress syndrome (RDS), necrotising enterocolitis (NEC) and intra-ventricular haemorrhage (IVH) in preterm babies; decreasing the neonatal mortality rate. There is no consensus on the dose of corticosteroid administered to the mother expected to have a preterm baby. This study is conducted to compare the effectiveness of two popular regimens of dexamethasone administration in decreasing incidence of RDS, necrotizing enterocolitis, IVH and neonatal mortality rate...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29073768/educating-parents-about-infant-language-development-a-randomized-controlled-trial
#19
Dana L Suskind, Christy Y Y Leung, Robert J Webber, Alison C Hundertmark, Kristin R Leffel, Iara E Fuenmayor Rivas, William A Grobman
A total of 427 women (aged 18-45 years) who delivered a singleton neonate without serious medical complications were randomized to watch either an educational intervention (n = 225) or the sudden infant death syndrome (n = 202) video. Linear mixed models showed that the intervention women significantly gained knowledge over time. Knowledge gain was largest among high-socioeconomic status (high-SES) and middle-SES English-speaking, smaller among low-SES Spanish-speaking, and nonsignificant among low-SES English-speaking women...
October 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/29072676/comparison-of-sprinting-vs-non-sprinting-to-wean-nasal-continuous-positive-airway-pressure-off-in-very-preterm-infants
#20
N Eze, D Murphy, V Dhar, V K Rehan
OBJECTIVE: Though nasal continuous positive airway pressure (NCPAP) is commonly used for non-invasive neonatal respiratory support, the optimal method of weaning NCPAP is not established. In this prospective, two-center randomized control trial we hypothesize that gradually increasing spontaneous breathing time off NCPAP increases successful weaning from NCPAP in infants born <31 weeks gestational age. STUDY DESIGN: Infants were randomized to one of the two NCPAP weaning protocols, a sprinting, that is, gradually increasing spontaneous breathing time off CPAP, protocol vs a non-sprinting (weaning pressure down) protocol...
October 26, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
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