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FTO vitamin D

Dilip K Yadav, Smeeta Shrestha, Karen A Lillycrop, Charu V Joglekar, Hong Pan, Joanna D Holbrook, Caroline Hd Fall, Chittaranjan S Yajnik, Giriraj R Chandak
AIM: To investigate the effect of B12 and/or folic acid supplementation on genome-wide DNA methylation. METHODS: We performed Infinium HumanMethylation450 BeadChip (Zymo Research, CA, USA) assay in children supplemented with B12 and/or folic acid (n = 12 in each group) and investigated the functional mechanism of selected differentially methylated loci. RESULTS: We noted significant methylation changes postsupplementation in B12 (589 differentially methylated CpGs and 2892 regions) and B12 + folic acid (169 differentially methylated CpGs and 3241 regions) groups...
January 2018: Epigenomics
Reina Armamento-Villareal, Neil Wingkun, Lina E Aguirre, Vibhati Kulkarny, Nicola Napoli, Georgia Colleluori, Clifford Qualls, Dennis T Villareal
OBJECTIVE: Fat mass and obesity-associated (FTO) gene polymorphisms have been reported to be associated with differences in BMI, obesity, and type 2 diabetes. However, previous studies have been predominantly conducted in younger individuals across a spectrum of body weights, whereas little information is available on the older population. We examined the association of FTO gene polymorphisms with cardiometabolic risks among adults who were both obese (BMI≥30 kg/m) and older (age≥65 years)...
December 24, 2015: Pharmacogenetics and Genomics
Marcus Bandstein, Bernd Schultes, Barbara Ernst, Martin Thurnheer, Helgi B Schiöth, Christian Benedict
BACKGROUND: A recent study in children demonstrated that the rs9939609 single-nucleotide polymorphism in the fat mass and obesity (FTO) gene influences prospective weight gain, however, only in those who were vitamin D-deficient. If this might also be the case for Roux-en-Y gastric bypass (RYGB), surgery-induced weight loss is however unknown. The objective of this study is to examine if the magnitude of RYGB surgery-induced weight loss after 2 years depends on patients' FTO rs9939609 genotype (i...
November 2015: Obesity Surgery
Shoaib Afzal, Peter Brøndum-Jacobsen, Stig E Bojesen, Børge G Nordestgaard
BACKGROUND: Low plasma 25-hydroxyvitamin D (25[OH]D) concentration and high BMI have been associated with increased risk of diabetes. We tested the hypotheses that genetic variants associated with low concentrations of 25(OH)D are associated with diabetes, and that the effect on diabetes of genetic variants associated with high BMI is partly mediated through reduced plasma 25(OH)D concentration. METHODS: In this mendelian randomisation study, we genotyped 96 423 white Danes aged 20-100 years from three studies...
April 2014: Lancet Diabetes & Endocrinology
Gaurav Garg, Jitender Kumar, Fiona E McGuigan, Martin Ridderstråle, Paul Gerdhem, Holger Luthman, Kristina Åkesson
UNLABELLED: Osteoporosis is characterized by reduced bone mineral density (BMD) and increased fracture risk. Fat mass is a determinant of bone strength and both phenotypes have a strong genetic component. In this study, we examined the association between obesity associated polymorphisms (SNPs) with body composition, BMD, Ultrasound (QUS), fracture and biomarkers (Homocysteine (Hcy), folate, Vitamin D and Vitamin B12) for obesity and osteoporosis. Five common variants: rs17782313 and rs1770633 (melanocortin 4 receptor (MC4R); rs7566605 (insulin induced gene 2 (INSIG2); rs9939609 and rs1121980 (fat mass and obesity associated (FTO) were genotyped in 2 cohorts of Swedish women: PEAK-25 (age 25, n = 1061) and OPRA (age 75, n = 1044)...
2014: PloS One
Corinne D Engelman
No abstract text is available yet for this article.
February 2014: Diabetes
Barbara H Lourenço, Lu Qi, Walter C Willett, Marly A Cardoso
Previous evidence suggests that variants in the fat mass and obesity-associated gene (FTO) affect adiposity in an age-dependent fashion in children, and nutritional factors may modify genotype effects. We assessed the effect of FTO rs9939609 on BMI and BMI-for-age Z score changes during childhood in a population-based longitudinal study in the Brazilian Amazon and investigated whether these effects were modified by vitamin D status, an important nutritional factor related to adiposity. At baseline, 1,088 children aged <10 years had complete genotypic and anthropometric data; 796 were followed up over a median 4...
February 2014: Diabetes
Yiannis Vasilopoulos, Theologia Sarafidou, Kalliopi Kotsa, Maria Papadimitriou, Yiannis Goutzelas, Costas Stamatis, Vasilis Bagiatis, Xanthi Tsekmekidou, John G Yovos, Zissis Mamuris
The prevalence of obesity has increased dramatically during the last thirty years in western countries with severe complications for health and economy. Obesity is the outcome of the strong interplay between genetic and environmental factors and is therefore widely expected that the discovery of the many genetic factors underlying the heritable risk of obesity will contribute critically to our basic knowledge of the disease etiopathogenesis and the identification of new targets for therapeutic intervention...
January 10, 2013: Gene
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