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Fat mass associated gene

Yongbo Kang, Yu Li, Yuhui Du, Liqiong Guo, Minghui Chen, Xinwei Huang, Fang Yang, Jingan Hong, Xiangyang Kong
BACKGROUND: Changes in the intestinal flora composition is referred to as dysbiosis, which is related to obesity development, thus supporting the potential roles of nutrients acting on intestinal flora to exert salutary effects on energetic metabolism of host. Dietary fiber has been known to affect the composition of intestinal flora. The aim of the present study was to investigate the functional effects of konjac flour (KF) on obesity control in respect to improving inflammation, metabolism, and intestinal barrier function, and the possible association of the effects with intestinal flora composition changes...
September 21, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Theodora Sideratou, Fiona Atkinson, Grace J Campbell, Peter Petocz, Kim S Bell-Anderson, Jennie Brand-Miller
Maternal diet and gestational hyperglycaemia have implications for offspring health. Leptin ( LEP ) and fat mass and obesity-associated ( FTO ) alleles are known to influence body fat mass in humans, potentially via effects on appetite. We hypothesized that expression of Fto , Lep , and other appetite-related genes ( Argp, Npy, Pomc, Cart, Lepr ) in the offspring of female mice are influenced by the glycaemic index (GI) of carbohydrates in the maternal diet. C57BL/6 mice were randomly assigned to low or high GI diets and mated with chow-fed males at eight weeks of age...
September 20, 2018: Nutrients
Yunlong Ma, Saixian Zhang, Kaili Zhang, Chengchi Fang, Shengsong Xie, Xiaoyong Du, Xinyun Li, Debin Ni, Shuhong Zhao
Identifying genetic basis of domestication and improvement in livestock contributes to our understanding of the role of artificial selection in genome shaping. Here we used whole-genome sequencing and the genotyping by sequencing approach to detect artificial selection signatures and identify the associated SNPs of two economic traits in Duroc pigs. A total of 38 candidate selection regions were detected by combining the fixation index and the Composite Likelihood Ratio methods. Further genome-wide association study revealed 7 associated SNPs that were related with intramuscular fat content and feed conversion ratio traits, respectively...
September 20, 2018: G3: Genes—Genomes—Genetics
Lan Wang, Jeremiah Perez, Nancy Heard-Costa, Audrey Y Chu, Roby Joehanes, Peter J Munson, Daniel Levy, Caroline S Fox, L Adrienne Cupples, Ching-Ti Liu
OBJECTIVE: Indices of body fat distribution are heritable, but few genetic signals have been reported from genome-wide association studies (GWAS) of computed tomography (CT) imaging measurements of body fat distribution. We aimed to identify genes associated with adiposity traits and the key drivers that are central to adipose regulatory networks. SUBJECTS: We analyzed gene transcript expression data in blood from participants in the Framingham Heart Study, a large community-based cohort (n up to 4303), as well as implemented an integrative analysis of these data and existing biological information...
September 19, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
María Fatima Garcés Da Silva, Yamil Adrian Guarin, Yenny Carrero, Hilda Stekman, María Luisa Núñez Bello, Celsy Hernández, Rafael Apitz, Mercedes Fernández-Mestre, Germán Camejo
Purpose: Fasting or postprandial hypertriglyceridemia is considered an independent cardiovascular disease (CVD) risk factor. The intestinal fatty acid binding protein (FABP2) is involved in the intracellular transport and metabolism of fatty acids. The presence of the Ala54Thr polymorphism of the FABP2 gene appears to be involved in postprandial hypertriglyceridemia. We explored the possible association of the Ala54Thr polymorphism with fat intolerance in apparently healthy, fasting, normolipidemic subjects with normal body-mass index and without diabetes...
September 13, 2018: Journal of Cardiovascular Development and Disease
Hiroki Okauchi, Chiaki Hashimoto, Reiko Nakao, Katsutaka Oishi
Inappropriate eating habits such as skipping breakfast and eating late at night are associated with risk for abnormal weight-gain and adiposity. We previously reported that time-imposed feeding during the daytime (inactive phase) induces obesity and metabolic disorders accompanied by physical inactivity in mice. The present study compares metabolic changes induced in mice by time-imposed feeding under voluntary wheel-running (RW) and sedentary (SED) conditions to determine the effects of voluntary wheel-running activity on obesity induced in mice by feeding at inappropriate times...
September 13, 2018: Chronobiology International
Jai Prakash, Balraj Mittal, Apurva Srivastava, Shally Awasthi, Neena Srivastava
Objectives: Obesity increases the risk of numerous chronic diseases. Obesity is classified clinically using body mass index (BMI), waist-to-hip ratio, and body fat percentage. The lipoprotein lipase ( LPL ) gene has been linked to lipoprotein metabolism and obesity. We performed a case-control study to determine the association between LPL gene polymorphisms and obesity-associated phenotypes such as insulin resistance (IR). Methods: We examined the different LPL gene variants for association in 642 individuals segregated by BMI and IR...
September 2018: Oman Medical Journal
Ilya R Bederman, Alexander DiScenna, Leigh Henderson, Aura Perez, Jeannie Klavanian, Daniel Kovtun, Olivia Collins, John Dunn, Bernadette O Erokwu, Chris A Flask, Mitchell L Drumm
Cystic fibrosis (CF) is a lethal genetic disorder that affects many organ systems of the body, including various endocrine and exocrine tissues. Health and survival positively associate with body mass and as a consequence, CF clinical care includes high-fat, high-calorie diets to maintain and increase adipose tissue stores. Such strategies have been implemented without a clear understanding of the cause and effect relationship between body mass and patients' health. Here, we use CF mouse models, which display small adipose stores, to begin examining body fat as a prelude into mechanistic studies of low body growth in CF, so that optimal therapeutic strategies can be developed...
September 6, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
Zhiwei Xia, Qingqing Man, Lixiang Li, Pengkun Song, Shanshan Jia, Shuang Song, Liping Meng, Jian Zhang
OBJECTIVES: The aim of this cross-sectional study was to investigate the association of serum 25-hydroxyvitamin D (25[OH]D) levels and vitamin D receptor (VDR) genotypes with skeletal muscle mass and function in elderly subjects in northern China. METHODS: A total of 275 men and 510 women, ages 63.1 to 72.5 y, in two randomly selected communities in Beijing were investigated. The investigation included a questionnaire, physical measurements, muscle mass and function measurements, serum 25(OH)D levels, and VDR gene polymorphisms analysis...
June 18, 2018: Nutrition
Patrizia Pasanisi, Eleonora Bruno, Elisabetta Venturelli, Daniele Morelli, Andreina Oliverio, Ivan Baldassari, Francesca Rovera, Giovanna Iula, Monica Taborelli, Bernard Peissel, Jacopo Azzolini, Siranoush Manoukian
BACKGROUND: Insulin-like growth factor I (IGF-I) and other markers of insulin resistance (IRm) might influence the penetrance of BRCA gene mutation. In a demonstration project on BRCA mutation carriers we tested the effect of the 'Mediterranean diet', with moderate protein restriction, on serum levels of IGF-I and IRm. METHODS: BRCA mutation carriers, with or without breast cancer, aged 18⁻70 years and without metastases were eligible. After the baseline examinations, women were randomized to an active dietary intervention or to a control group...
September 4, 2018: Cancers
Georgia Colleluori, Lina E Aguirre, Clifford Qualls, Rui Chen, Nicola Napoli, Dennis T Villareal, Reina Armamento-Villareal
Estradiol (E2), mainly produced from Testosterone (T) in men, promotes visceral lipolysis. However, high visceral fat and hyperestrogenemia are features of obese hypogonadal (HG) men. Our study objectives are to evaluate relationships between circulating E2 and: (1) fat mass; (2) Estrogen Receptor α ( ESR1) expression in subcutaneous adipose tissue; (3) changes in body fat after 6 months (M) of T therapy in HG men. HYPOTHESES: (1) existence of a range of circulating E2 associated with better body composition; (2) serum E2 determines tissue E2 sensitivity which affects response to T therapy...
September 4, 2018: Nutrients
Xueyu Yan, Yanjun Wu, Fangjie Zhong, Qinyang Jiang, Tingting Zhou, Yafen Guo, Xiurong Yang, Jing Liang, D Joshua Liao, Ganqiu Lan
Type 2 diabetes mellitus (T2DM) is a complex, multifactorial metabolic disease, and the number of patients with T2DM has continued to increase in recent years. Large-scale proteomic studies on animal models of T2DM are of great importance to understand the pathophysiology of T2DM. Therefore, in our study, Isobaric tags for relative and absolute quantification (iTRAQ) and Parallel reaction monitoring (PRM) were used for proteomic analysis of skeletal muscles from T2DM-susceptible and -tolerant Bama mini-pig models induced by a high-fat, high-sugar diet...
October 30, 2018: Gene
Anas Sabarneh, Suheir Ereqat, Stéphane Cauchi, Omar AbuShamma, Mohammad Abdelhafez, Murad Ibrahim, Abdelmajeed Nasereddin
BACKGROUND: Genetic and environmental factors play a crucial role in the development of type 2 diabetes mellitus (T2DM) and obesity. This study aimed to investigate the association of the fat-mass and obesity-associated gene (FTO) rs9939609 variant with T2DM and body mass index (BMI) among Palestinian population. METHODS: A total of 399 subjects were recruited, of whom 281 were type 2 diabetic patients and 118 normoglycemic subjects. All of them were unrelated, aged > 40 years and recruited within the period 2016-2017...
August 31, 2018: BMC Medical Genetics
Aakansha Sharma, Devraj Singh, Shalie Malik, Neelu Jain Gupta, Sangeeta Rani, Vinod Kumar
We hypothesized differences in molecular strategies for similar journeys that migrants undertake to reproduce in spring and to overwinter in autumn. We tested this in redheaded buntings ( Emberiza bruniceps ) photoinduced into spring and autumn migratory states, with winter and summer non-migratory states as controls. Compared with controls, buntings fattened, gained weight and showed Zugunruhe (nocturnal migratory restlessness) in the migratory state. Spring migration was associated with greater fat and body mass, and higher intensity of Zugunruhe , compared with autumn migration...
August 29, 2018: Proceedings. Biological Sciences
Agata Leońska-Duniec, Pawel Cieszczyk, Zbigniew Jastrzębski, Aleksandra Jażdżewska, Ewelina Lulińska-Kuklik, Waldemar Moska, Krzysztof Ficek, Marta Niewczas, Agnieszka Maciejewska-Skrendo
In this study we examined the genotype distribution of the PPARD rs2267668, rs2016520, and rs1053049 alleles in a group of women, before and after the completion of a 12-week training program. There were two significant genotype × training interactions resulting in decreases of total cholesterol (Chol) through training in rs2267668 G allele carriers and significant increases of triglyceride (TGL) levels in rs2267668 AA homozygotes. Carriers of rs2016520 PPARD C allele exhibited a significant decrease in Chol through training with an accompanying decrease in TGL...
2018: PloS One
Veera Vihma, Sini Heinonen, Jussi Naukkarinen, Jaakko Kaprio, Aila Rissanen, Ursula Turpeinen, Esa Hämäläinen, Antti Hakkarainen, Jesper Lundbom, Nina Lundbom, Tomi S Mikkola, Matti J Tikkanen, Kirsi H Pietiläinen
OBJECTIVE: Obesity may alter serum steroid concentrations and metabolism. We investigated this in healthy young women with increased body fat and their leaner co-twin sisters. DESIGN: Age and genetic background both strongly influence serum steroid levels and body composition. This is a cross-sectional study of 13 female monozygotic twin pairs (age, 23-36 years), ten of which were discordant for body mass index (median difference in body weight between the co-twins, 19 kg)...
August 25, 2018: Steroids
Fanny Petermann, Marcelo Villagrán, Claudia Troncoso, Lorena Mardones, Ana María Leiva, María Adela Martínez, Alex Garrido-Méndez, Felipe Poblete-Valderrama, Carlos Salas-Bravo, Robinson Ramírez-Vélez, Natalia Ulloa, Francisco Pérez-Bravo, Carlos Celis-Morales
BACKGROUND: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. AIM: To investigate the association of FTO gene with adiposity markers in Chilean adults. MATERIAL AND METHODS: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio...
June 2018: Revista Médica de Chile
Thi Thu Huong Do, Garcia Marie, Dalle Héloïse, Dorothée Guillaume, Moldes Marthe, Fève Bruno, Buyse Marion
Insulin resistance is frequently present in patients with glucocorticoid (GC) excess (Cushing's syndrome) or treated with high doses of GCs. Furthermore, others similarities between metabolic syndrome (visceral obesity, elevated blood glucose levels, dyslipidemia) and Cushing's syndrome suggest that GCs could play a role in obesity-linked complications. Here we reported that long-term corticosterone (CORT) exposure in mice induced weight gain, dyslipidemia as well as hyperglycaemia and systemic insulin resistance...
August 23, 2018: Journal of Steroid Biochemistry and Molecular Biology
Yehui Duan, Lingyu Zhang, Fengna Li, Qiuping Guo, Cimin Long, Yulong Yin, Xiangfeng Kong, Mijun Peng, Wence Wang
BACKGROUND: The effects and roles of the leucine (Leu) metabolite β-hydroxy-β-methylbutyrate (HMB) in lipid metabolism in adipose tissues of pigs are still unknown. OBJECTIVES: This study was conducted to investigate the effects of excess Leu versus HMB on growth, carcass traits, and lipid metabolism in adipose tissues of growing pigs. METHODS AND RESULTS: Compared to control, the Leu/HMB group significantly increased/reduced weight of total fat mass, respectively, with a concurrent increase of serum adiponectin concentration (P < 0...
September 19, 2018: Food & Function
Leonardo Mendes de Souza Mesquita, Cíntia Rabelo E Paiva Caria, Paola Souza Santos, Caio Cesar Ruy, Natalia da Silva Lima, Débora Kono Taketa Moreira, Claudia Quintino da Rocha, Daniella Carisa Murador, Veridiana Vera de Rosso, Alessandra Gambero, Wagner Vilegas
No scientific report proves the action of the phytochemicals from the mangrove tree Rhizophora mangle in the treatment of diabetes. The aim of this work is to evaluate the effects of the acetonic extract of R. mangle barks (AERM) on type 2 diabetes. The main chemical constituents of the extract were analyzed by high-performance liquid chromatography (HPLC) and flow injection analysis electrospray-iontrap mass spectrometry (FIA-ESI-IT-MS/MS). High-fat diet (HFD)-fed mice were used as model of type 2 diabetes associated with obesity...
August 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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