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Fat mass associated gene

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https://www.readbyqxmd.com/read/29677190/a-haplotype-of-three-snps-in-fto-had-a-strong-association-with-body-composition-and-bmi-in-iranian-male-adolescents
#1
Naser Kalantari, Nastaran Keshavarz Mohammadi, Pantea Izadi, Saeid Doaei, Maryam Gholamalizadeh, Hassan Eini-Zinab, Tuire Salonurmi, Shahram Rafieifar, Reza Janipoor, Ghasem Azizi Tabesh
BACKGROUND: Single-nucleotide polymorphisms (SNPs), which are located in the first intron of the FTO gene, are reported to be associated with body weight and the body mass index (BMI). However, their effects on anthropometric measurements in adolescents are poorly understood. OBJECTIVE: This study aimed to investigate the association of three adjacent polymorphisms (rs9930506, rs9930501, & rs9932754) in the FTO gene with anthropometric indices in Iranian adolescent males...
2018: PloS One
https://www.readbyqxmd.com/read/29675043/cardiovascular-risk-factors-after-childhood-cancer-treatment-are-independent-of-the-fto-gene-polymorphism
#2
Małgorzata Sawicka-Żukowska, Maryna Krawczuk-Rybak, Paweł Bernatowicz, Katarzyna Muszyńska-Rosłan, Jerzy Konstantynowicz, Włodzimierz Łuczyński
The study objective was to assess the prevalence of cardiovascular disease risk factors in patients treated for childhood cancer ( N = 101) and to determine the involvement of clinical (cancer type and therapy) and/or genetic ( FTO gene rs9939609 polymorphism) factors. Anthropometric features, laboratory findings, and standardized osteodensitometric indices (fat and lean mass) were considered. Overweight/obesity was found in 17.82% of the patients; however, central adiposity was found in as many as 42.5%. At least one abnormality in lipid metabolism was observed in 35...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29663892/complement-components-c3-and-c4-and-the-metabolic-syndrome
#3
Melanie Copenhaver, Chack-Yung Yu, Robert P Hoffman
INTRODUCTION: Increased systemic inflammation is engaged likely plays a significant role in the development of adult cardiometabolic diseases such as insulin resistance, dyslipidemia, atherosclerosis, and hypertension. The complement system is part of the innate immune system and plays a key role in in regulation inflammation. Of particular importance is the activation of complement components C3 and C4. C3 is produced primarily by the liver but is also produced in adipocytes, macrophages and endothelial cells, all of which are present in adipose tissue...
April 17, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29663401/variants-in-the-ppargc1a-gene-may-influence-the-effect-of-fat-intake-on-resting-metabolic-rate-in-obese-women
#4
Sajjad Moradi, Khadijeh Mirzaei, Zhila Maghbooli, Ahmed A Abdurahman, Seyed Ali Keshavarz
Recent studies have shown that dietary intake and genetic variants play a decisive role in the risk of obesity. Therefore, this study was designed to examine the interaction between dietary fat and PPARGC1A polymorphisms on the level of resting metabolic rate (RMR). We enrolled 288 Iranian overweight and obese women in this cross-sectional study. We sequenced the 648 b.p. DNA in Exon 8 of PPARGC1A gene. We analyzed the two single-nucleotide polymorphisms, namely rs11290186 and rs2970847, in this region. All participants were assessed for RMR, dietary intake, and body composition...
April 16, 2018: Lipids
https://www.readbyqxmd.com/read/29661414/dexmedetomidine-metabolic-clearance-is-not-affected-by-fat-mass-in-obese-patients
#5
A Rolle, S Paredes, L I Cortínez, B J Anderson, N Quezada, S Solari, F Allende, J Torres, D Cabrera, V Contreras, J Carmona, C Ramírez, A M Oliveros, M Ibacache
BACKGROUND: Obesity has been associated with reduced dexmedetomidine clearance, suggesting impaired hepatic function or reduced hepatic blood flow. The aim of this study was to clarify the effect of obesity in dexmedetomidine metabolic clearance. METHODS: Forty patients, ASA I-III, 18-60 yr old, weighing 47-126 kg, scheduled for abdominal laparoscopic surgery, were enrolled. Anaesthetic agents (propofol, remifentanil, and dexmedetomidine) were dosed based on lean body weight measured by dual X-ray absorptiometry...
May 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29657248/association-of-fat-mass-and-obesity-associated-and-retinitis-pigmentosa-guanosine-triphosphatase-gtpase-regulator-interacting-protein-1-like-polymorphisms-with-body-mass-index-in-chinese-women
#6
Boyu Chen, Zhiqiang Li, Jianhua Chen, Jue Ji, Jingyi Shen, Yufeng Xu, Yingying Zhao, Danping Liu, Yinhuan Shen, Weijie Zhang, Jiawei Shen, Yonggang Wang, Yongyong Shi
Body mass index (BMI) is the most commonly used quantitative measure of adiposity. It is a kind of complex genetic diseases which are caused by multiple susceptibility genes. The first intron of fat mass and obesity-associated (FTO) has been widely discovered to be associated with BMI. Retinitis pigmentosa GTPase regulator-interacting protein-1 like (RPGRIP1L) is located in the upstream region of FTO and has been proved to be linked with obesity through functional tests. We carried out a genetic association analysis to figure out the role of the FTO gene and the RPGRIP1L gene in BMI...
April 14, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29655790/hdac11-deletion-reduces-fructose-induced-cardiac-dyslipidemia-apoptosis-and-inflammation-by-attenuating-oxidative-stress-injury
#7
Xiao-Di Fan, Lan-Lan Wan, Man Duan, Shan Lu
Diabetes mellitus (DM) is a risk factor for abnormal heart development, but the molecular mechanism remains obscure. Histone deacetylase 11 (HDAC11), the most recently identified histone deacetylase, is the sole member of class IV HDACs. However, its role in diabetic cardiac injury is still poorly understood. In the present study, we attempted to explore the effects of HDAC11 on fructose (Fru)-induced cardiac injury using the wild type (HDAC11+/+ ) and knockout (HDAC11-/- ) mice. The results indicated that HDAC11 was significantly expressed in human and mouse diabetic heart failure (DHF) hearts...
April 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29608557/a-high-throughput-functional-screen-of-human-body-mass-index-gwas-loci-using-tissue-specific-rnai-drosophila-melanogaster-crosses
#8
Thomas J Baranski, Aldi T Kraja, Jill L Fink, Mary Feitosa, Petra A Lenzini, Ingrid B Borecki, Ching-Ti Liu, L Adrienne Cupples, Kari E North, Michael A Province
Human GWAS of obesity have been successful in identifying loci associated with adiposity, but for the most part, these are non-coding SNPs whose function, or even whose gene of action, is unknown. To help identify the genes on which these human BMI loci may be operating, we conducted a high throughput screen in Drosophila Melanogaster. Starting with 78 BMI loci from two recently published GWAS meta-analyses, we identified fly orthologs of all nearby genes (± 250KB). We crossed RNAi knockdown lines of each gene with flies containing tissue-specific drivers to knock down (KD) the expression of the genes only in the brain and the fat body...
April 2, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29606151/fto-variant-is-not-associated-with-osteoarthritis-in-the-chinese-han-population-replication-study-for-a-genome-wide-association-study-identified-risk-loci
#9
Jin Dai, Pu Ying, Dongquan Shi, Huacheng Hou, Ye Sun, Zhihong Xu, Dongyang Chen, Guoqiang Zhang, Ming Ni, Huajian Teng, Yan Wang, Qing Jiang
BACKGROUND: Osteoarthritis is the most prevalent form of arthritis worldwide and is the major cause of pain and loss of function in elderly people. A signal of the fat mass and obesity-associated (FTO) gene had been reported in a genome-wide association study of osteoarthritis. The FTO polymorphism (rs8044769) might exert its effect on osteoarthritis through obesity, because it was reported as a body mass index-associated single-nucleotide polymorphism. And replication studies showed inconsistent results for this association...
April 2, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29600520/identification-of-differentially-regulated-deceitful-proteins-in-sh-sy5y-cells-engineered-with-tet-regulated-protein-expression-system
#10
Aylin Kanli, Murat Kasap, Kubra K Yoneten, Gurler Akpinar, Mehmet Dogan Gulkac
Tetracycline regulated protein expression in mammalian cells is a powerful tool to predict the physiological function, cellular localization, and stability of a protein. In addition, to predict metabolic networks affected by the expression of wild-type or mutant forms of proteins, researchers generally produce a single mammalian cell clone that can express the protein of interest under tetracycline control and study the changes occurring in overall proteome before and after expression of a protein of interest...
March 30, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29598829/depletion-of-dnmt1-in-differentiated-human-cells-highlights-key-classes-of-sensitive-genes-and-an-interplay-with-polycomb-repression
#11
Karla M O'Neill, Rachelle E Irwin, Sarah-Jayne Mackin, Sara-Jayne Thursby, Avinash Thakur, Ciske Bertens, Laura Masala, Jayne E P Loughery, Darragh G McArt, Colum P Walsh
BACKGROUND: DNA methylation plays a vital role in the cell, but loss-of-function mutations of the maintenance methyltransferase DNMT1 in normal human cells are lethal, precluding target identification, and existing hypomorphic lines are tumour cells. We generated instead a hypomorphic series in normal hTERT-immortalised fibroblasts using stably integrated short hairpin RNA. RESULTS: Approximately two-thirds of sites showed demethylation as expected, with one-third showing hypermethylation, and targets were shared between the three independently derived lines...
March 29, 2018: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/29597287/opposite-genetic-effects-of-cmip-polymorphisms-on-the-risk-of-type-2-diabetes-and-obesity-a-family-based-study-in-china
#12
Yaying Cao, Tao Wang, Yiqun Wu, Juan Juan, Xueying Qin, Xun Tang, Tao Wu, Yonghua Hu
C-Maf Inducing Protein ( CMIP ) gene polymorphisms were reported to be associated with type 2 diabetes mellitus (T2DM). Whether the association between CMIP and T2DM is mediated via obesity-related phenotypes is still unclear. We analyzed the association of CMIP rs2925979 with T2DM and a comprehensive set of obesity-related phenotypes in 1576 families ascertained from a Chinese population. These families included a total of 3444 siblings (1582 with T2DM, 963 with prediabetes, and 899 with a normal glucose level)...
March 28, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29596868/troponin-t3-associates-with-dna-consensus-sequence-that-overlaps-with-p53-binding-motifs
#13
Yury O Nunez Lopez, Maria Laura Messi, Richard E Pratley, Tan Zhang, Osvaldo Delbono
We recently reported that in addition to its classical cytoplasmic location, the fast skeletal muscle Troponin T3 (TnT3) shuttles to the nucleus, where it appears to perform nonclassical transcription regulatory functions. Importantly, changes in the composition of the nucleus-localized pool of TnT3 and its fragments contribute to age-dependent muscle damage and wasting. Here, using ChIP-Seq, we demonstrate that TnT3 associates with DNA consensus sequences including the TGCCT motif, which is required for p53 binding to the promoter area of p53-related genes...
March 26, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29596463/inhibin-%C3%AE-e-inhbe-is-a-possible-insulin-resistance-associated-hepatokine-identified-by-comprehensive-gene-expression-analysis-in-human-liver-biopsy-samples
#14
Masakazu Sugiyama, Akihiro Kikuchi, Hirofumi Misu, Hirobumi Igawa, Motooki Ashihara, Youichi Kushima, Kiyofumi Honda, Yoshiyuki Suzuki, Yoshiki Kawabe, Shuichi Kaneko, Toshinari Takamura
The liver plays a major role in whole-body energy homeostasis by releasing secretory factors, termed hepatokines. To identify novel target genes associated with insulin resistance, we performed a comprehensive analysis of gene expression profiles using a DNA chip method in liver biopsy samples from humans with varying degrees of insulin resistance. Inhibin βE (INHBE) was identified as a novel putative hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans...
2018: PloS One
https://www.readbyqxmd.com/read/29593555/ileal-transposition-surgery-decreases-fat-mass-and-improves-glucose-metabolism-in-diabetic-gk-rats-possible-involvement-of-fgf21
#15
Kemin Yan, Weijie Chen, Huijuan Zhu, Guole Lin, Hui Pan, Naishi Li, Linjie Wang, Hongbo Yang, Meijuan Liu, Fengying Gong
Objective: Ileal transposition (IT) surgery has been reported to improve glucose and lipid metabolism, and fibroblast growth factor 21 (FGF21) is a powerful metabolic regulator. In the present study, we aimed to investigate the effects of IT surgery on metabolism and its possible relationship with the FGF21 signaling pathway in diabetic Goto-Kakizaki (GK) rats. Methods: Ten-week-old male GK rats were subjected to IT surgery with translocation of a 10 cm ileal segment to the proximal jejunum (IT group) or sham surgery without the ileum transposition (Sham-IT group)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29580854/metabolomics-based-evidence-of-the-hypoglycemic-effect-of-ge-gen-jiao-tai-wan-in-type-2-diabetic-rats-via-uhplc-qtof-ms-analysis
#16
Wenbo Wang, Linlin Zhao, Zhenyu He, Ning Wu, Qiuxia Li, Xinjian Qiu, Lu Zhou, Dongsheng Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Ge-Gen-Jiao-Tai-Wan (GGJTW) formula, derived from traditional Chinese herbal medicine, is composed of Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep (Ge-Gen in Chinese), Coptis chinensis Franch (Huang-Lian), and Cinnamomum cassia (L.) J. Presl (Rou-Gui). GGJTW is used for treatment of diabetes in China, reflecting the potent hypoglycemic effect of its ingredients. However, little is known of the hypoglycemic effect of GGJTW and the underlying metabolic mechanism...
March 23, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29568104/gut-microbiome-related-lct-genotype-and-2-year-changes-in-body-composition-and-fat-distribution-the-pounds-lost-trial
#17
Yoriko Heianza, Dianjianyi Sun, Wenjie Ma, Yan Zheng, Catherine M Champagne, George A Bray, Frank M Sacks, Lu Qi
BACKGROUND/OBJECTIVES: Gut microbiome regulates host energy metabolism and adiposity. A recent study identified a genome-wide significant variant in the lactase (LCT) gene that determines gut-microbiome abundance. We investigated whether the LCT variant influenced long-term changes in adiposity among overweight and obese individuals. SUBJECTS/METHODS: We included 583 whites with LCT variant rs4988235 (G allele as Bifidobacterium-abundance-increasing allele) who were randomly assigned to one of four weight-loss diets varying in macronutrient contents...
February 26, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29568102/enhanced-hexose-6-phosphate-dehydrogenase-expression-in-adipose-tissue-may-contribute-to-diet-induced-visceral-adiposity
#18
Limei Liu, Ying Wang, Jian Wang, Yunzhou Dong, Scarlett Chang, Xiwen Liu, Kabirullah Lutfy, Hong Chen, Theodore C Friedman, Meisheng Jiang, Yanjun Liu
BACKGROUND: Visceral fat accumulation increases the risk of developing type 2 diabetes and metabolic syndrome, and is associated with excessive glucocorticoids (GCs). Fat depot-specific GC action is tightly controlled by 11ß-hydroxysteroid dehydrogenase (11ß-HSD1) coupled with the enzyme hexose-6-phosphate dehydrogenase (H6PDH). Mice with inactivation or activation of H6PDH genes show altered adipose 11ß-HSD1 activity and lipid storage. We hypothesized that adipose tissue H6PDH activation is a leading cause for the visceral obesity and insulin resistance...
February 22, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29560930/gene-expression-signature-of-obesity-in-monozygotic-twins
#19
Francesc Font-Clos, Stefano Zapperi, Caterina A M La Porta
OBJECTIVE: Observational studies suggest that obesity might have a Mendelian origin, but it is not clear if gene expression patterns observed in obese subjects are secondary to genetic traits or not. 
 Approach: Here we test a transcriptomic signature of obesity previously identified by our group
 on a large cohort of twin subjects (TwinsUK). 
 Main results: The results show that the signature correlates strongly both with the body mass index (BMI) and fat mass...
March 21, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29546309/supplementation-with-resveratrol-and-curcumin-does-not-affect-the-inflammatory-response-to-a-high-fat-meal-in-older-adults-with-abdominal-obesity-a-randomized-placebo-controlled-crossover-trial
#20
Cécile Vors, Charles Couillard, Marie-Eve Paradis, Iris Gigleux, Johanne Marin, Marie-Claude Vohl, Patrick Couture, Benoît Lamarche
Background: High-fat meals induce postprandial inflammation. Resveratrol is a polyphenol known to prevent comorbidities associated with cardiovascular disease and exerts an anti-inflammatory action. There is also an increasing body of evidence supporting the role of curcumin, a polyphenol from the curcuminoid family, as a modulator of proinflammatory processes. Objective: The objectives of this study were to investigate the following: 1) the bioavailability of resveratrol consumed in combination with curcumin after consumption of a high-fat meal; and 2) the acute combined effects of this combination on the postprandial inflammatory response of subjects with abdominal obesity...
March 1, 2018: Journal of Nutrition
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