Luis A Rivera, Pablo E Hernández, Danielle T Vannan, José L Reyes, Tonathiu Rodríguez, Ángel Sánchez-Barrera, Marisol I González, José Bustos, Oscar A Ramos, Imelda Juárez, Miriam Rodriguez-Sosa, Alicia Vázquez
PURPOSE: To explore the role of the proinflammatory cytokine, macrophage migration inhibitory factor (MIF), in a murine model of dry eye disease (DED). METHODS: The role of MIF on DED was determined using genetically MIF deficient mice and pharmacological inhibition of MIF. DED was induced with 0.5 mg of scopolamine via subcutaneous injection in wild type (WT) and mice lacking MIF (Mif-/- ), three times a day for 21 days. DED signs, tear volume, ferning pattern and cytology impression were evaluated...
December 21, 2023: Ocular Immunology and Inflammation