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https://www.readbyqxmd.com/read/29050425/sodium-butyrate-improved-performance-while-modulating-the-cecal-microbiota-and-regulating-the-expression-of-intestinal-immune-related-genes-of-broiler-chickens
#1
C Bortoluzzi, A A Pedroso, J J Mallo, M Puyalto, W K Kim, T J Applegate
This study evaluated the effect of sodium butyrate (SB) on performance, expression of immune-related genes in the cecal tonsils, and cecal microbiota of broiler chickens when dietary energy and amino acids concentrations were reduced. Day-old male Ross 708 broiler chicks were fed dietary treatments in a 3 × 2 factorial design (8 pens per treatment) with 3 dietary formulations (control diet; reduction of 2.3% of amino acids and 60 kcal/kg; and reduction of 4.6% of amino acids and 120 kcal/kg) with or without the inclusion of 0...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29050424/a-functional-single-nucleotide-polymorphism-in-the-tyrosinase-gene-promoter-affects-skin-color-and-transcription-activity-in-the-black-boned-chicken
#2
S Yu, J Liao, M Tang, Y Wang, X Wei, L Mao, C Zeng, G Wang
The tyrosinase (TYR) gene is the major melanogenesis-related gene for skin (fur) or plumage color in mammals and birds. Genetic variation in the promoter region of a gene may affect gene expression and phenotypes. This study compared the TYR promoter region between pooled DNA (n = 8) of chickens (Gallus gallus) with black and white skin using direct sequencing. The single nucleotide polymorphism (SNP) c.-2228A>T was found to have the opposite allele distribution in the two groups. The results of genotyping in a larger population (n = 188) revealed that SNP c...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29050382/distinct-18f-av-1451-tau-pet-retention-patterns-in-early-and-late-onset-alzheimer-s-disease
#3
Michael Schöll, Rik Ossenkoppele, Olof Strandberg, Sebastian Palmqvist, Jonas Jögi, Tomas Ohlsson, Ruben Smith, Oskar Hansson
Patients with Alzheimer's disease can present with different clinical phenotypes. Individuals with late-onset Alzheimer's disease (>65 years) typically present with medial temporal lobe neurodegeneration and predominantly amnestic symptomatology, while patients with early-onset Alzheimer's disease (<65 years) exhibit greater neocortical involvement associated with a clinical presentation including dyspraxia, executive dysfunction, or visuospatial impairment. We recruited 20 patients with early-onset Alzheimer's disease, 21 with late-onset Alzheimer's disease, three with prodromal early-onset Alzheimer's disease and 13 with prodromal late-onset Alzheimer's disease, as well as 30 cognitively healthy elderly controls, that had undergone 18F-AV-1451 tau positron emission tomography and structural magnetic resonance imaging to explore whether early- and late-onset Alzheimer's disease exhibit differential regional tau pathology and atrophy patterns...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29050365/mitochondrial-genome-variation-and-prostate-cancer-a-review-of-the-mutational-landscape-and-application-to-clinical-management
#4
REVIEW
Anton M F Kalsbeek, Eva K F Chan, Niall M Corcoran, Christopher M Hovens, Vanessa M Hayes
Prostate cancer is a genetic disease. While next generation sequencing has allowed for the emergence of molecular taxonomy, classification is restricted to the nuclear genome. Mutations within the maternally inherited mitochondrial genome are known to impact cancer pathogenesis, as a result of disturbances in energy metabolism and apoptosis. With a higher mutation rate, limited repair and increased copy number compared to the nuclear genome, the clinical relevance of mitochondrial DNA (mtDNA) variation requires deeper exploration...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050287/association-between-the-mvk-and-mmab-polymorphisms-and-serum-lipid-levels
#5
Liu Miao, Rui-Xing Yin, Shang-Ling Pan, Shuo Yang, De-Zhai Yang, Wei-Xiong Lin
Maonan ethnic group is a relatively conservative and isolated minority in China. Little is known about the association of the mevalonate kinase (MVK), methylmalonic aciduria (cobalamin deficiency) cblB type (MMAB) single nucleotide polymorphisms (SNPs) and serum lipid levels. This study aimed to determine the association between four SNPs in the MVK/MMAB and serum lipid levels. Genotyping of the rs3759387, rs877710, rs7134594 and rs9593 SNPs was performed in 1264 Maonan subjects and 1251 Han participants. Allele and genotype frequencies of the selected SNPs were different between the two populations (P < 0...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050244/the-prognostic-impacts-of-tea-domain-tead-transcription-factor-polymorphisms-in-chinese-hepatocellular-carcinoma-patients
#6
Haiyan Xia, Juan Wen, Weiyong Zhao, Dongying Gu, Zhibin Hu, Jinfei Chen, Zhi Xu
TEA domain (TEAD) transcription factors play an important role in hepatocellular carcinoma (HCC) development and progression by regulating the expression of a number of genes. However, the association of their genetic variations with HCC prognosis remains elusive. Seven potentially functional single nucleotide polymorphisms in TEAD1-4 (rs2304733, rs10831923, rs12104362, rs3745305, rs11756089, rs2076173, rs7135838) were genotyped from 331 hepatitis B virus positive HCC patients using the Sequenom MassARRAY iPLEX platform...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050087/-study-on-the-correlation-between-meteorological-factors-and-acute-otitis-media-in-outpatients-of-children-in-beijing
#7
Y X Lu, J Q Liang, Q L Gu, X M Yu, X Yan
Objective: To explore the characteristics of acute otitis media(AOM) in children in Beijing and its correlation with meteorological factors. Methods: Data were collected in 2011-2013 in the Otolaryngology Department of Capital Institute of Pediatrics. AOM in children with relevant information, such as age, sex and season, with the same period of the Beijing municipal meteorological data (the average temperature, average pressure, average wind speed, humidity and PM2.5) were compared to analysis the relationship of meteorological environmental parameters and the onset of AOM in children...
October 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29050040/maximal-fat-oxidation-is-related-to-performance-in-an-ironman-triathlon
#8
Jacob Frandsen, Stine Dahl Vest, Steen Larsen, Flemming Dela, Jørn W Helge
The aim of the present study was to investigate the relationship between maximal fat oxidation rate (MFO) measured during a progressive exercise test on a cycle ergometer and ultra-endurance performance. 61 male ironman athletes (age: 35±1 yrs. [23-47 yrs.], with a BMI of 23.6±0.3 kg/m(2) [20.0-30.1 kg/m(2)], a body fat percentage of 16.7±0.7% [8.4-30.7%] and a VO2peak of 58.7±0.7 ml/min/kg [43.9-72.5 ml/min/kg] SEM [Range]) were tested in the laboratory between 25 and 4 days prior to the ultra-endurance event, 2016 Ironman Copenhagen...
October 19, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29050017/specificities-of-caries-on-root-surface
#9
Nailê Damé-Teixeira, Clarissa Cavalcanti Fatturi Parolo, Marisa Maltz
Variations in organic and inorganic composition and morphology may determine different susceptibilities of root surfaces to caries. Subsequent to gingival recession, root surfaces become exposed and those areas where Sharpey's fibers system was once inserted into the cementum are converted into canals for microbial penetration. In the presence of a cariogenic root biofilm, the fermentable carbohydrate from diet is converted into organic acid, and the root caries lesion is initiated in the exposed root site...
2017: Monographs in Oral Science
https://www.readbyqxmd.com/read/29050005/effect-of-salt-intake-on-serum-glucagon-like-peptide-1-levels-in-normotensive-salt-sensitive-subjects
#10
Wen-Ling Zheng, Chao Chu, Yong-Bo Lv, Yang Wang, Jia-Wen Hu, Qiong Ma, Yu Yan, Yu-Meng Cao, Xi-Long Dang, Ke-Ke Wang, Jian-Jun Mu
BACKGROUND/AIMS: Excess dietary salt is a critical risk factor of salt-sensitive hypertension. Glucagon-like peptide-1 (GLP-1) , a gut incretin hormone, conferring benefits for blood pressure by natriuresis and diuresis. We implemented a randomized trial to verify the effect of altered salt intake on serum GLP-1 level in human beings. METHODS: The 38 subjects were recruited from a rural community of Northern China. All subjects were sequentially maintained a baseline diet period for 3 days, a low-salt diet period for 7 days (3...
October 19, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29049968/a-novel-eulerian-approach-for-modelling-cyanobacteria-movement-thin-layer-formation-and-recurrent-risk-to-drinking-water-intakes
#11
Mouhamed Ndong, David Bird, Tri Nguyen Quang, René Kahawita, David Hamilton, Marie Laure de Boutray, Michèle Prévost, Sarah Dorner
Toxic cyanobacteria (CB) blooms are being reported in an increasing number of water bodies worldwide. As drinking water (DW) treatment can be disrupted by CB, in addition to long term management plans, short term operational decision-making tools are needed that enable an understanding of the temporal variability of CB movement in relation to drinking water intakes. In this paper, we propose a novel conservative model based on a Eulerian framework and compare results with data from CB blooms in Missisquoi Bay (Québec, Canada)...
October 10, 2017: Water Research
https://www.readbyqxmd.com/read/29049943/occurrence-and-profile-of-organophosphorus-compounds-in-fine-and-coarse-particulate-matter-from-two-urban-areas-of-china-and-pakistan
#12
Yasir Faiz, Naila Siddique, Huan He, Cheng Sun, Shahida Waheed
Seven organophosphorus compounds (OPs) were measured in urban fine and coarse particulate matter (PM) collected from two sites of Nanjing (XCNUC), China and Islamabad (APHSP), Pakistan. The fine PM mass at APHSP site was significantly higher (p = 0.005) in the spring (mean 22.5 μg/m(3)) than in the summer (mean 12.7 μg/m(3)). The total concentration, ∑(7)OPs, of samples collected at APHSP was found significantly higher in coarse (range 672-47621 pg/m(3)) than in fine PM (range 1200-15213 pg/m(3)); while ∑(7)OPs from XCNUC in fine (range 1696-15063 pg/m(3)) and coarse PM (range 2053-5379 pg/m(3)) were statistically different in samples during summer, based on two-sample t-test at 0...
October 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29049916/immune-cell-type-fingerprints-at-the-basis-of-outcome-diversity-of-human-infection
#13
REVIEW
Shelly Hen-Avivi, Roi Avraham
Despite the availability of antibiotics and immunization, infectious diseases remain a major cause of malignancy and death worldwide. Yet, it is well documented that for most infectious agents, clinical disease develops in only a small minority of infected individuals. There is, in fact, great heterogeneity in infection outcome, from complete clearance of the pathogen to severe illness. Understanding this variation remains elusive, despite its great potential to equip us with new tools for the treatment of infectious diseases...
October 16, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29049876/rational-design-of-three-dimensional-graphene-encapsulated-with-hollow-fep-carbon-nanocomposite-as-outstanding-anode-material-for-lithium-ion-and-sodium-ion-batteries
#14
Xiujuan Wang, Kai Chen, Gang Wang, Xiaojie Liu, Hui Wang
Transition metal phosphides (TMPs) have been extensively investigated owing to their high theoretical capacities and relatively low intercalation potentials vs. Li/Li+, but their practical applications have been hindered by low electrical conductivity and dramatic volume variation during cycling. In this work, an interesting strategy for rational design of graphene (GR) encapsulated with hollow FeP@carbon nanocomposite (H-FeP@C@GR) via a combination of hydrothermal route, carbon coating process, phosphidation treatment, and carbothermic reaction is reported...
October 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/29049845/impact-of-the-initial-fitness-level-on-the-effects-of-a-structured-exercise-therapy-during-pediatric-stem-cell-transplantation
#15
Susanne Wallek, Anna Senn-Malashonak, Lutz Vogt, Katharina Schmidt, Peter Bader, Winfried Banzer
BACKGROUND: Before and after hematopoietic stem cell transplantation (HSCT), most patients suffer from psychophysical limitations due to the treatment. Exercise interventions demonstrate beneficial effects on, for example, strength, endurance, or health-related quality of life during and after HSCT, but with a great variation among patients concerning the response to exercise. This study examines the influence of the initial fitness on the effects of an exercise therapy in pediatric HSCT...
October 19, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29049686/national-practice-variation-in-pneumonectomy-perioperative-care-among-canadian-thoracic-surgeons
#16
Biniam Kidane, John K Peel, Andrew Seely, Richard A Malthaner, Christian Finley, Sean Grondin, Brian E Louie, Sadeesh Srinathan, Gail E Darling
OBJECTIVES: Our objective was to assess perioperative pneumonectomy practices among Canadian thoracic surgeons as part of a quality-improvement initiative to determine practice variability and identify areas for study/improvement. METHODS: After several rounds of survey development and piloting, a 29-item survey was distributed using the Dillman method to all practicing members of the Canadian Association of Thoracic Surgeons. RESULTS: The response rate was 87% (62 of 71)...
July 28, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049629/do-older-listeners-with-hearing-loss-benefit-from-dynamic-pitch-for-speech-recognition-in-noise
#17
Jing Shen, Pamela E Souza
Purpose: Dynamic pitch, the variation in the fundamental frequency of speech, aids older listeners' speech perception in noise. It is unclear, however, whether some older listeners with hearing loss benefit from strengthened dynamic pitch cues for recognizing speech in certain noise scenarios and how this relative benefit may be associated with individual factors. We first examined older individuals' relative benefit between natural and strong dynamic pitches for better speech recognition in noise...
October 12, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/29049627/international-outcome-inventory-for-hearing-aids-data-from-a-large-swedish-quality-register-database
#18
Stig Arlinger, Peter Nordqvist, Marie Öberg
Purpose: The purpose of this study was to analyze a database of completed International Outcome Inventory for Hearing Aids (IOI-HA) questionnaires obtained from over 100,000 clients fitted with new hearing aids in Sweden during the period of 2012-2016. Mean IOI-HA total scores were correlated with degree of hearing loss, unilateral versus bilateral fitting, first-time versus return clients, gender, and variation among dispensing clinics. The correlations with expectations, service quality, and technical functioning of the hearing aids were also analyzed...
October 12, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/29049619/field-monitoring-of-otoacoustic-emissions-during-noise-exposure-pilot-study-in-controlled-environment
#19
Vincent Nadon, Annelies Bockstael, Dick Botteldooren, Jérémie Voix
Purpose: In spite of all the efforts to implement workplace hearing conservation programs, noise-induced hearing loss remains the leading cause of disability for North American workers. Nonetheless, an individual's susceptibility to noise-induced hearing loss can be estimated by monitoring changes in hearing status in relation to the level of ambient noise exposure. The purpose of this study was to validate an approach that could improve workplace hearing conservation practices. The approach was developed using a portable and robust system designed for noisy environments and consisted of taking continuous measurements with high temporal resolution of the health status of the inner ear using otoacoustic emissions (OAEs)...
October 12, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/29049546/a-unique-variation-with-five-branches-of-the-aortic-arch
#20
Zeliang Ma, Jing Han, Haozhong Li, Kaihua Guo
Here, we present a unique case with 5 branches of the aortic arch (AA), namely the right common carotid artery, left common carotid artery, left thyrocervical trunk, left subclavian artery and right subclavian artery (RSA), from right to left. We found that the left thyrocervical trunk originated directly from the AA rather than the left subclavian artery. In addition, the RSA arose dorsally as the last branch of the AA and passed posteriorly to the oesophagus to supply the right upper limb. In addition, the right vertebral artery originated from the right common carotid artery instead of the RSA...
August 17, 2017: Interactive Cardiovascular and Thoracic Surgery
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