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https://www.readbyqxmd.com/read/29458136/changes-in-anatomic-position-of-root-canal-orifices-in-pluriradicular-teeth-following-re-location-during-endodontic-treatment
#1
Darian Rusu, Petra Surlin, Stratul Stefan-Ioan, Marius Boariu, Calniceanu Horia, Adrian Kasaj, Cosmin Sinescu, Didilescu Andreea
Direct access to the root canals in posterior teeth for endodontic treatment is most frequently facilitated by the straightening of the coronal parts of the root canals, having as a consequence the relocation of the canal orifices on the map of the floor of the pulp chamber (Christie & Thompson, 1994). This procedure intentionally moves the coronal aspect of a canal away from the center of the chamber, while simultaneously removing internal dentin from the pulp chamber walls. The aim of this study was to evaluate the displacement resulting from the relocation of root canal orifices during the initial phase of rotary root canal treatment in molars using the dental operating microscope (DOM) and digital image processing...
February 16, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29458122/regional-variations-of-cortical-bone-in-the-humeral-head-region-a-preliminary-study
#2
Yeming Wang, Jian Li, Jianhua Yang, Jingming Dong
BACKGROUND: Incidence of proximal humeral fractures dramatically increased over the last decade due to demographic changes. The goal of this study was to analyze regional characteristics of cortical bone in the humeral head region using cortical bone mapping (CBM) technique. METHODS: The proximal humerus of 103 healthy volunteers was imaged by clinical computed tomography (CT) scans. Three groups of volunteers were identified according to age: group A (20-39 years), group B (40-59 years), and group C (>60 years)...
February 16, 2018: Bone
https://www.readbyqxmd.com/read/29458073/establishment-and-validation-of-a-prediction-model-for-ischemic-stroke-risks-in-patients-with-type-2-diabetes
#3
Tsai-Chung Li, Hsiang-Chi Wang, Chia-Ing Li, Chiu-Shong Liu, Wen-Yuan Lin, Chih-Hsueh Lin, Sing-Yu Yang, Cheng-Chieh Lin
AIMS: A risk scoring system for predicting ischemic stroke incidence may identify type 2 diabetes patients at high risk for ischemic stroke who can benefit from preventive intervention programs. Such a risk scoring system can serve as a benchmark to test novel putative risk factors. METHODS: The study adopted a retrospective cohort, including 28,124 Chinese patients with type 2 diabetes aged 30-84 years during 2001-2004. Participants were randomly assigned to the derivation and validation sets at a 2:1 ratio...
February 16, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29458049/a-comprehensive-brca1-2-ngs-pipeline-for-an-immediate-copy-number-variation-cnv-detection-in-breast-and-ovarian-cancer-molecular-diagnosis
#4
Paola Concolino, Roberta Rizza, Flavio Mignone, Alessandra Costella, Donatella Guarino, Ilaria Carboni, Ettore Capoluongo, Concetta Santonocito, Andrea Urbani, Angelo Minucci
No abstract text is available yet for this article.
February 16, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29458007/a-genomically-characterized-collection-of-high-grade-serous-ovarian-cancer-xenografts-for-preclinical-testing
#5
Paulina Cybulska, Jocelyn M Stewart, Azin Sayad, Carl Virtanen, Patricia A Shaw, Blaise Clarke, Natalie Stickle, Marcus Q Bernardini, Benjamin G Neel
High-grade serous ovarian cancer (HGSC) is the leading cause of morbidity and mortality from gynecologic malignancy. Overall survival remains low, due to the nearly ubiquitous emergence of platinum-resistance and the paucity of effective next-line treatments. Current cell culture-based models show limited similarity to HGSC and are therefore unreliable predictive models for pre-clinical evaluation of investigational drugs. This deficiency could help explain the low overall rate of successful drug development and the decades of largely unchanged approaches to HGSC treatment...
February 16, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29457960/phylogenetic-relationships-and-acaricidal-effects-of-beauveria-bassiana-obtained-from-cattle-farm-soils-against-rhipicephalus-microplus
#6
Agustin Fernández-Salas, Miguel Angel Alonso Díaz, Rogelio Alejandro Alonso Morales, Roberto Lezama-Gutierrez, José Antonio Cervantes-Chávez
The objectives of the present study were to isolate Beauveria bassiana strains from cattle farms soils, to analyze the phylogenetic relationships among the isolated fungi strains, and to determine the acaricidal effect of B. bassiana isolates on Rhipicephalus microplus engorged ticks, resistant or susceptible to chemical acaricides. Six strains of Beauveria bassiana were obtained and isolated from cattle farms soils by Galleria bait method in Mexican tropics and the acaricidal effect was assessed against 2 populations of R...
February 19, 2018: Journal of Parasitology
https://www.readbyqxmd.com/read/29457904/conflict-in-the-mechanism-and-kinetics-of-the-barrierless-reaction-between-sh-and-no-2-radicals
#7
Ramanpreet Kaur, Vikas
There are some unsettled issues regarding the mechanism and kinetics of an important atmospheric reaction of NO2 radical with the SH radical. The existing mechanism is based on the formation of HSO and NO radicals, both of which can result only along one barrierless channel. However, the detection of NO radical has never been reported though the formation of HSO radical has been followed in some studies to determine the rate constants. The latter are mainly obtained by monitoring the SH decay, but rate constants are reported to be highly conflicting among the existing studies reporting its value ranging from 10-10 to 10-12 cm3 molecule-1 sec-1 ...
February 19, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29457875/variations-of-the-circle-of-willis-at-the-end-of-the-human-embryonic-period
#8
Kana Furuichi, Aoi Ishikawa, Chigako Uwabe, Haruyuki Makishima, Shigehito Yamada, Tetsuya Takakuwa
Variations of the circle of Willis (CW) influence blood supply to the brain and adjacent structures in adults. We examined the formation of the CW in 20 human embryo samples at the end of the embryonic period using 3-D reconstructions of serial histological sections. The CW was closed in all samples, and did not form in a single plane, but was composed of multiple stair-like planes. The artery acutely curved at the caudal part of the CW, namely at the inlet of the basilar artery and bifurcation of the P1 segment of the posterior cerebral artery (PCA), reflecting flexure of the mesencephalon and diencephalon at this stage...
February 19, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29457829/species-specific-susceptibility-to-cannabis-induced-convulsions
#9
Benjamin J Whalley, Hong Lin, Lynne Bell, Thomas Hill, Amesha Patel, Roy A Gray, C Elizabeth Roberts, Orrin Devinsky, Michael Bazelot, Claire M Williams, Gary J Stephens
BACKGROUND AND PURPOSE: Numerous claims are made for cannabis' therapeutic utility upon human seizures, but concerns persist about risks. A potential confounder is the presence of both Δ9 -tetrahydrocannabinol (Δ9 -THC), variously reported to be pro- and anti-convulsant, and cannabidiol (CBD), widely confirmed as anticonvulsant. Therefore, we investigated effects of prolonged exposure to different Δ9 -THC/CBD cannabis extracts on seizure activity and associated measures of endocannabinoid (eCB) system signalling...
February 19, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29457803/temperature-and-humidity-calibration-of-a-low-cost-wireless-dust-sensor-for-real-time-monitoring
#10
Hannaneh Hojaiji, Haik Kalantarian, Alex A T Bui, Christine E King, Majid Sarrafzadeh
This paper introduces the design, calibration, and validation of a low-cost portable sensor for the real-time measurement of dust particles within the environment. The proposed design consists of low hardware cost and calibration based on temperature and humidity sensing to achieve accurate processing of airborne dust density. Using commercial particulate matter sensors, a highly accurate air quality monitoring sensor was designed and calibrated using real world variations in humidity and temperature for indoor and outdoor applications...
March 2017: 2017 IEEE Sens Appl Symp (SAS) (2017)
https://www.readbyqxmd.com/read/29457794/recon3d-enables-a-three-dimensional-view-of-gene-variation-in-human-metabolism
#11
Elizabeth Brunk, Swagatika Sahoo, Daniel C Zielinski, Ali Altunkaya, Andreas Dräger, Nathan Mih, Francesco Gatto, Avlant Nilsson, German Andres Preciat Gonzalez, Maike Kathrin Aurich, Andreas Prlić, Anand Sastry, Anna D Danielsdottir, Almut Heinken, Alberto Noronha, Peter W Rose, Stephen K Burley, Ronan M T Fleming, Jens Nielsen, Ines Thiele, Bernhard O Palsson
Genome-scale network reconstructions have helped uncover the molecular basis of metabolism. Here we present Recon3D, a computational resource that includes three-dimensional (3D) metabolite and protein structure data and enables integrated analyses of metabolic functions in humans. We use Recon3D to functionally characterize mutations associated with disease, and identify metabolic response signatures that are caused by exposure to certain drugs. Recon3D represents the most comprehensive human metabolic network model to date, accounting for 3,288 open reading frames (representing 17% of functionally annotated human genes), 13,543 metabolic reactions involving 4,140 unique metabolites, and 12,890 protein structures...
February 19, 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29457781/efficient-synthesis-of-tungsten-oxide-hydrate-based-nanocomposites-for-applications-in-bifunctional-electrochromic-energy-storage-devices
#12
Xueting Chang, Ruirui Hu, Shibin Sun, Tong Lu, Tao Liu, Yanhua Lei, Lihua Dong, Yansheng Yin, Yanqiu Zhu
In this work, we realized the large-scale synthesis of WO3·H2O nanoflakes (NFs), g-C3N4/WO3·H2O nanocomposite (NC) and graphene (G)/WO3·H2O NC via a sonochemical process with tungsten salt as the precursor, g-C3N4 or G sheets as the supports, and distilled water as the solvent. Both the g-C3N4/WO3·H2O NC and the G/WO3·H2O NC exhibited much better EC performance (higher coloration efficiencies and faster response times) than that of the WO3·H2O NFs. Using the WO3·H2O-based materials as electrode materials, EC batteries that integrate the energy storage and EC functions in one device have been assembled...
February 19, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29457755/novel-approach-for-ces1-genotyping-integrating-single-nucleotide-variants-and-structural-variation
#13
Ditte Bjerre, Henrik Berg Rasmussen
AIM: Development of a specific procedure for genotyping of CES1A1 (CES1) and CES1A2, a hybrid of CES1A1 and the pseudogene CES1P1. MATERIALS & METHODS: The number of CES1A1 and CES1A2 copies and that of CES1P1 were determined using real-time PCR. Long range PCRs followed by secondary PCRs allowed sequencing of single nucleotide variants in CES1A1 and CES1A2. Results & conlusion: A procedure consisting of two main steps was developed. Its first main step, the copy number determination, informed about presence of CES1A2 ...
February 19, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29457751/intra-and-inter-fraction-uncertainties-during-igrt-for-wilms-tumor
#14
Filipa Guerreiro, Enrica Seravalli, Geert O Janssens, Cees P van de Ven, Marry M van den Heuvel-Eibrink, Bas W Raaymakers
BACKGROUND AND PURPOSE: To assess intra- and inter-fraction motion uncertainties, due to displacements of the tumor bed (TB) and organs at risk (OAR), as well as intra- and inter-fraction patient set-up uncertainties, due to positioning variations, during image-guided radiation therapy (IGRT) in children with Wilms' tumor. MATERIAL AND METHODS: Four-dimensional computed tomography (4D-CT) and daily pre- and post-treatment cone-beam CT (CBCT)-scans of 15 patients (average 4, range 1-8 years) undergoing flank irradiation after nephrectomy were analyzed...
February 19, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29457708/stress-enhanced-interlayer-exchange-coupling-and-optical-mode-fmr-frequency-in-self-bias-fecob-ru-fecob-trilayers
#15
Shandong Li, Guo-Xing Miao, Derang Cao, Qiang Li, Jie Xu, Zheng Wen, Youyong Dai, Shi-Shen Yan, Yueguang Lü
Nowadays, the most popular method to increase ferromagnetic resonance (FMR) frequency (fr ) in self-bias soft magnetic films is to improve the anisotropy field HK . However, to push fr to higher frequencies only via raising HK becomes increasingly challenging since fr is already higher than 10 GHz by now. In this study, we fabricated a series of magnetically anisotropic FeCoB/Ru/FeCoB sandwich films possessing antiferromagnetic-like coupling and gradually increased uniaxial stress in the FeCoB sublayers from 52 to 110 MPa...
February 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29457655/importance-of-growth-rate-on-hg-and-pcb-bioaccumulation-in-fish
#16
Jiajia Li, G Douglas Haffner, Gordon Paterson, David M Walters, Michael D Burtnyk, Ken G Drouillard
To evaluate the effect of fish growth on mercury (Hg) and polychlorinated biphenyls (PCBs) bioaccumulation, a non-steady state toxicokinetic model, combined with a Wisconsin bioenergetics model, was developed to simulate Hg and PCB bioaccumulation in Bluegill (Lepomis macrochirus). The model was validated by comparing observed versus predicted Hg and PCB 180 concentrations across 5 age classes from five different waterbodies across North America. The non-steady state model generated accurate predictions for Hg and PCB bioaccumulation in three of five waterbodies: Apsey, Sharbot and Stonelick Lake...
February 19, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29457586/origin-of-distorted-1t-phase-res-2-first-principles-study
#17
Ji-Hae Choi, Seung-Hoon Jhi
Group-VIIB transition metal dichalcogenides (TMDCs) are known to be stabilized solely in a distorted 1T phase termed as 1T″ phase, which is compared to many stable or metastable phases in other TMDCs. Using first-principles calculations, we study the structural origin of 1T″ phase group-VIIB TMDCs. We find that quasi 1D Peierls-like instability is responsible for the transition to the 1T″ phase ReS2 monolayer from the 1T' phase, another distorted 1T phase. Two half-filled bands in 1T'-ReS2 make sharp peaks in the Lindhard function that prompt the charge density wave (CDW) phase with large band gap opening...
February 19, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29457576/hypoalbuminaemia-as-a-marker-of-trans-capillary-leakage-in-community-acquired-bacteraemia-patients
#18
K O Gradel, P J Vinholt, B Magnussen, C Pedersen, T G Jensen, H J Kolmos, A T Lassen
Community-acquired bacteraemia patients (n = 2472), Denmark, 2000-2008. Albumin, C-reactive protein (CRP) and haemoglobin (Hb) measured 2000-2010. We assessed daily mean levels of albumin, CRP and Hb from 30 days before to 30 days after bacteraemia and correlations between albumin vs. CRP and albumin vs. Hb. In linear regression models, we evaluated the contribution of CRP, Hb, chronic and acute variables to the albumin level variations. The mean albumin level (33.6 g/l) was steady before day 1, declined to 29...
February 19, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29457534/comparing-hydrogels-for-human-nucleus-pulposus-cell-regeneration-role-of-osmolarity-during-expansion
#19
Anita Krouwels, Ferry Melchels, Mattie H P Van Rijen, F Cumhur Oner, Wouter Dhert, M Tryfonidou, Laura Creemers
Hydrogels can facilitate nucleus pulposus regeneration, either for clinical application or research into mechanisms of regeneration. However, many different hydrogels and culture conditions for human degenerated nucleus pulposus (NP) have been employed, making literature data difficult to compare. Therefore, we compared six different hydrogels of natural polymers and investigated the role of serum in the medium and of osmolarity during expansion or redifferentation in an attempt to provide comparators for future studies...
February 17, 2018: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29457528/quantitative-trait-loci-influencing-hb-f-levels-in-southern-thai-hb-e-hbb-c-79g-a-heterozygotes
#20
Aumpika Kesornsit, Nutjaree Jeenduang, Dararat Horpet, Thunyaluk Plyduang, Manit Nuinoon
Variation of fetal hemoglobin (Hb F) expression in heterozygous Hb E (HBB: c.79G>A) individuals is associated with several genetic modifiers and not well understood. This study was undertaken in order to determine the effect of single nucleotide polymorphisms (SNPs), including XmnIG γ (rs7482144), rs766432 on the BCL11A gene and rs9376074 on the HBS1L gene, on Hb F levels in Southern Thai heterozygous Hb E individuals. A total of 97 Southern Thai subjects carrying heterozygous Hb E were selected for the hematological study...
February 19, 2018: Hemoglobin
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