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https://www.readbyqxmd.com/read/29668111/efficient-in-planta-gene-targeting-in-tomato-using-geminiviral-replicons-and-the-crispr-cas9-system
#1
Tal Dahan-Meir, Shdema Filler-Hayut, Cathy Melamed-Bessudo, Samuel Bocobza, Henryk Czosnek, Asaph Aharoni, Avraham A Levy
Current breeding relies mostly on random mutagenesis and recombination to generate novel genetic variation. However, targeted genome editing is becoming an increasingly important tool for precise plant breeding. Using the CRISPR-Cas system combined with the bean yellow dwarf virus rolling circle replicon we optimized a method for targeted mutagenesis and gene replacement in tomato. The carotenoid isomerase (CRTISO) and phytoene synthase 1 (PSY1) genes from the carotenoid biosynthesis pathway were chosen as targets due to their easily detectable change of phenotype...
April 18, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29668076/comparative-analyses-of-the-gut-microbiota-among-three-different-wild-geese-species-in-the-genus-anser
#2
Wen Wang, Yingbao Liu, Yongsheng Yang, Aizhen Wang, Kirill Sharshov, Yao Li, Mengyao Cao, Puzhen Mao, Laixing Li
In this study, we characterized for the first time the gut microbiota of Greylag geese (Anser anser) using high-throughput 16S rRNA gene sequencing technology. The results showed that the phyla Firmicutes (78.55%), Fusobacteria (9.38%), Proteobacteria (7.55%), Bacteroidetes (1.82%), Cyanobacteria (1.44%), and Actinobacteria (0.61%) dominated the gut microbial communities in the Greylag geese. Then, the variations of gut microbial community structures and functions among the three geese species, Greylag geese, Bar-headed geese (Anser indicus), and Swan geese (Anser cygnoides), were explored...
April 18, 2018: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29668067/social-inequality-in-cancer-survivors-health-behaviours-a-danish-population-based-study
#3
K Friis, F B Larsen, C V Nielsen, A-M H Momsen, C M Stapelfeldt
The aim of this study was to compare health behaviours (smoking, alcohol consumption, physical activity and diet), to explore social inequality in these behaviours among cancer survivors and individuals with no history of cancer, respectively, and to study the impact of time since diagnosis on cancer survivors' health behaviours. Data from the Danish National Health Survey from 2013 were linked with data from the Danish Cancer Registry to identify all cancer diagnoses among the respondents during the period 1945-2012...
April 18, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29668061/ligand-tuneable-red-emitting-iridium-iii-complexes-for-efficient-triplet-triplet-annihilation-upconversion-performance
#4
Simon J Pope, Thomas Stonelake, Kaitlin Phillips, Simon Coles, Peter Horton, Shannon Keane, Emily Stokes, Ian Fallis, Joseph Beames, Jianzhang Zhao, Kepeng Chen, Yuqi Hou, Andrew Hallett, Sean O'Kell
A series of substituted 2-phenylquinoxaline ligands have been explored to finely tune the visible emission properties of a corresponding set of cationic, cyclometalated iridium(III) complexes. The electronic and redox properties of the complexes were investigated using experimental (including time-resolved luminescence and transient absorption spectroscopy) and theoretical methods. The complexes display absorption and phosphorescent emission in the visible region attributed to MLCT transitions. The different substitution patterns of the ligands induce variations in these parameters...
April 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29668016/genetic-and-ecological-niche-modeling-of-calydorea-crocoides-iridaceae-an-endemic-species-of-subtropical-highland-grasslands
#5
Juliana Lustosa Matos de Alencar, Eliane Kaltchuk-Santos, Juliana Fachinetto, Luana Olinda Tacuatiá, Eliana Regina Forni-Martins, Eudes Maria Stiehl-Alves, Tatiana Teixeira de Souza-Chies
Evolutionary analyses have been widely used for evaluation of genetic diversity of natural populations and correlate these data to the fitness of the species, especially in the case of threatened species. Calydorea crocoides occurs in a restricted area at altitudes from 800 to 1500 m in southern Brazil and is considered endangered. A study assessing genetic diversity, cytogenetic features and ecological niche was performed aiming to characterize C. crocoides by multidisciplinary approaches. Molecular data highlighted that most of the total variation (76%; p < 0...
2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29668015/skull-shape-and-size-variation-within-and-between-mendocinus-and-torquatus-groups-in-the-genus-ctenomys-rodentia-ctenomyidae-in-chromosomal-polymorphism-context
#6
Rodrigo Fornel, Pedro Cordeiro-Estrela, Thales Renato O de Freitas
We tested the association between chromosomal polymorphism and skull shape and size variation in two groups of the subterranean rodent Ctenomys. The hypothesis is based on the premise that chromosomal rearrangements in small populations, as it occurs in Ctenomys, produce reproductive isolation and allow the independent diversification of populations. The mendocinus group has species with low chromosomal diploid number variation (2n=46-48), while species from the torquatus group have a higher karyotype variation (2n=42-70)...
2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29667933/a-cbct-study-of-the-gravity-induced-movement-in-rotating-rabbits
#7
Jeffrey Barber, Chun-Chien Shieh, William Counter, Jonathan R Sykes, Peter Bennett, Verity Ahern, Stéphanie Corde, Soo-Min Heng, Paul White, Michael Jackson, Paul Liu, Paul J Keall, Ilana Feain
Fixed-beam radiotherapy systems with subjects rotating about a longitudinal (horizontal) axis are subject to gravity-induced motion. Limited reports on the degree of this motion, and any deformation, has been reported previously. The purpose of this study is to quantify the degree of anatomical motion caused by rotating a subject around a longitudinal axis, using cone-beam CT (CBCT). &#13; &#13; In the current study, a purpose-made longitudinal rotating was aligned to a Varian TrueBeam kV imaging system...
April 18, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29667850/a-survey-of-fellowship-trained-upper-extremity-surgeons-on-treatment-of-lateral-epicondylitis
#8
Steven R Niedermeier, Nisha Crouser, Amy Speeckaert, Kanu S Goyal
BACKGROUND: The aim of the study is to investigate current management strategies for lateral epicondylitis by fellowship-trained upper extremity surgeons. METHODS: A 17-question survey of treatment approaches and outcomes related to lateral epicondylitis was sent to 3354 surgeons using the American Society for Surgery of the Hand and American Shoulder and Elbow Surgeons member databases. RESULTS: Six hundred twelve upper extremity surgeons completed the survey...
April 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29667780/variability-in-vertebral-numbers-does-not-contribute-to-sexual-size-dimorphism-interspecific-variability-or-phenotypic-plasticity-in-body-size-in-geckos-squamata-gekkota-paroedura
#9
Lukáš Kratochvíl, Lukáš Kubička, Martin Vohralík, Zuzana Starostová
Body size is a fundamental trait correlated with nearly every aspect of animal life. It is influenced by numerous genetic and non-genetic factors. Despite its central importance, proximate mechanisms of intra- and interspecific variability in body size are still not well understood even in such a largely studied group as reptiles. For our study, we concentrated on the gecko species Paroedura picta. We investigated whether differences in sexual size dimorphism and in final and asymptotic snout-vent length (induced by a range of incubation and rearing temperatures) are correlated with differences in the number of presacral vertebrae...
April 18, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29667742/genetic-association-and-expression-analyses-of-the-phosphatidylinositol-4-phosphate-5-kinase-pip5k1c-gene-in-alcohol-use-disorder-relevance-for-pain-signaling-and-alcohol-use
#10
Ji Soo Lee, Jill L Sorcher, Allison D Rosen, Ruslan Damadzic, Hui Sun, Melanie Schwandt, Markus Heilig, John Kelly, Kelsey L Mauro, Audrey Luo, Daniel Rosoff, Christine Muench, Jeesun Jung, Zachary A Kaminsky, Falk W Lohoff
BACKGROUND: The gene encoding Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) has been recently implicated in pain regulation. Interestingly, a recent cross-tissue and cross-phenotypic epigenetic analysis identified the same gene in alcohol use disorder (AUD). Given the high comorbidity between AUD and chronic pain, we hypothesized that genetic variation in PIP5K1C might contribute to susceptibility to AUD. METHODS: We conducted a case-control association study of genetic variants in PIP5K1C...
April 18, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29667728/comparison-of-10-efficient-protocols-for-photodynamic-therapy-of-actinic-keratosis-how-relevant-are-effective-light-dose-and-local-damage-in-predicting-the-complete-response-rate-at-3-months
#11
Anne-Sophie Vignion-Dewalle, Gregory Baert, Elise Thecua, Fabienne Lecomte, Claire Vicentini, Henry Abi-Rached, Laurent Mortier, Serge Mordon
BACKGROUND: Topical photodynamic therapy is an established treatment modality for various dermatological conditions, including actinic keratosis. In Europe, the approved protocols for photodynamic therapy of actinic keratosis involve irradiation with either an Aktilite CL 128 lamp or daylight, whereas irradiation with the Blu-U illuminator is approved in the United States. Many other protocols using irradiation by a variety of light sources are also clinically efficient. OBJECTIVES: This paper aims to compare 10 different protocols with clinically proven efficacy for photodynamic therapy of actinic keratosis and the available spectral irradiance of the light source...
April 18, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29667703/diagnosis-and-management-practices-for-gestational-diabetes-mellitus-in-australia-cross-sectional-survey-of-the-multidisciplinary-team
#12
Nina Meloncelli, Adrian Barnett, Fiona Pelly, Susan de Jersey
BACKGROUND: Gestational diabetes mellitus (GDM) is one of the most common pregnancy disorders; however, if well managed, women with GDM experience similar pregnancy outcomes to those without. Currently, there is limited evidence on actual management practices across Australia or how multidisciplinary teams interact to optimise care. AIMS: To examine the current screening, diagnostic, task and role perceptions and management practices, as reported by members of the GDM multidisciplinary team...
April 18, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29667666/a-luminescent-benzothiadiazole-bridging-bis-salicylaldiminato-zinc-ii-complex-with-mechanochromic-and-organogelation-properties
#13
Xiaoxian Song, Hanbo Yu, Xianju Yan, Yuewei Zhang, Yang Miao, Kaiqi Ye, Yue Wang
Herein, a new bis(salicylaldiminato)Zn(ii) Schiff base complex, BTZn, derived from benzo[c][1,2,5]thiadiazole-5,6-diamine was designed and synthesized. It exhibited unique mechanical force-induced luminescence change characteristic. Upon mechanical grinding, the as-prepared BTZn solid crystalized from an ethanol/dichloromethane solution displays a high-contrast emission-colour variation from yellow (emission maximum λem = 545 nm) to red (λem = 645 nm), and this emission variation can be erased through solvent vapour treatment...
April 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29667604/universal-doping-evolution-of-the-superconducting-gap-anisotropy-in-single-crystals-of-electron-doped-ba-fe-sub-1-x-sub-rh-sub-x-sub-sub-2-sub-as-sub-2-sub-from-london-penetration-depth-measurements
#14
Hyunsoo Kim, Makariy A Tanatar, Catalin Martin, Erick C Blomberg, Ni Ni, Sergey L Bud'ko, Paul C Canfield, Ruslan Prozorov
Doping evolution of the superconducting gap anisotropy was studied in single crystals of 4$d$-electron doped Ba(Fe$_{1-x}$Rh$_x$)$_2$As$_2$ using tunnel diode resonator measurements of the temperature variation of London penetration depth $\Delta\lambda(T)$. Single crystals with doping level representative of underdoped regime $x$ = 0.039 ($T_c=$ 15.5 K), close to optimal doping $x=$ 0.057 ($T_c=$ 24.4 K) and overdoped $x=$ 0.079 ($T_c=$ 21.5 K) and $x=$ 0.131($T_c=$ 4.9 K) were studied. Superconducting energy gap anisotropy was characterized by the exponent, $n$, by fitting the data to the power-law, $\Delta\lambda=AT^n$...
April 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29667599/sensitive-singular-phase-optical-detection-without-phase-measurements-with-tamm-plasmons
#15
Svetlana V Boriskina, Yoichiro Tsurimaki
Spectrally-tailored interactions of light with material interfaces offer many exciting applications in sensing, photo-detection, and optical energy conversion. In particular, complete suppression of light reflectance at select frequencies accompanied by sharp phase variations in the reflected signal forms the basis for the development of ultra-sensitive singular-phase optical detection schemes such as Brewster and surface plasmon interferometry. However, both the Brewster effect and surface-plasmon-mediated absorption on planar interfaces are limited to one polarization of the incident light and oblique excitation angles, and may have limited bandwidth dictated by the material dielectric index and plasma frequency...
April 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29667573/molecular-epidemiology-of-extraintestinal-pathogenic-escherichia-coli
#16
James R Johnson, Thomas A Russo
Extraintestinal pathogenic Escherichia coli (ExPEC) are important pathogens in humans and certain animals. Molecular epidemiological analyses of ExPEC are based on structured observations of E. coli strains as they occur in the wild. By assessing real-world phenomena as they occur in authentic contexts and hosts, they provide an important complement to experimental assessment. Fundamental to the success of molecular epidemiological studies are the careful selection of subjects and the use of appropriate typing methods and statistical analysis...
April 2018: EcoSal Plus
https://www.readbyqxmd.com/read/29667559/improving-the-rhinomanometry-technique-using-benzoin-tincture
#17
F Arslan, Ü Yıldızoğlu, A Durmaz, S Çetinkaya
OBJECTIVE: In order to achieve a faster and more reliable anterior rhinomanometric evaluation, nasal skin was prepared using benzoin tincture solution, which provides simpler and better adhesion of the foam tape to the nasal skin. METHOD: Two consecutive anterior rhinomanometry measurements were made, one with and one without benzoin tincture application. RESULTS: The average time taken to perform classic foam tape anterior rhinomanometry without benzoin tincture application was 281...
April 18, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29667509/the-involvement-of-cancer-patients-in-the-four-stages-of-decision-making-preceding-continuous-sedation-until-death-a-qualitative-study
#18
Lenzo Robijn, Jane Seymour, Luc Deliens, Ida Korfage, Jayne Brown, Peter Pype, Agnes Van Der Heide, Kenneth Chambaere, Judith Rietjens
BACKGROUND: Involving patients in decision-making is considered to be particularly appropriate towards the end of life. Professional guidelines emphasize that the decision to initiate continuous sedation should be made in accordance with the wishes of the dying person and be preceded by their consent. AIM: To describe the decision-making process preceding continuous sedation until death with particular attention to the involvement of the person who is dying. DESIGN: Qualitative case studies using interviews...
April 1, 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29667462/glucosamine-for-the-treatment-of-osteoarthritis-the-time-has-come-for-higher-dose-trials
#19
Mark F McCarty, James H O'Keefe, James J DiNicolantonio
Although clinical trials with glucosamine in osteoarthritis have yielded mixed results, leading to doubts about its efficacy, the utility of glucosamine for preventing joint destruction and inflammation is well documented in rodent models of arthritis, including models of spontaneous osteoarthritis. The benefit of oral glucosamine in adjuvant arthritis is markedly dose dependent, likely reflecting a modulation of tissue levels of UDP-N-acetylglucosamine that in turn influences mucopolysaccharide synthesis and the extent of protein O-GlcNAcylation...
April 18, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29667364/heritability-of-body-size-in-the-polar-bears-of-western-hudson-bay
#20
René M Malenfant, Corey S Davis, Evan S Richardson, Nicholas J Lunn, David W Coltman
Among polar bears (Ursus maritimus), fitness is dependent on body size through males' abilities to win mates, females' abilities to provide for their young, and all bears' abilities to survive increasingly longer fasting periods caused by climate change. In the Western Hudson Bay subpopulation (near Churchill, Manitoba, Canada), polar bears have declined in body size and condition, but nothing is known about the genetic underpinnings of body size variation, which may be subject to natural selection. Here, we combine a 4449-individual pedigree and an array of 5433 single-nucleotide polymorphisms (SNPs) to provide the first quantitative genetics study of polar bears...
April 18, 2018: Molecular Ecology Resources
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