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https://www.readbyqxmd.com/read/28426752/somatic-copy-number-alterations-in-gastric-adenocarcinomas-among-asian-and-western-patients
#1
Steven E Schumacher, Byoung Yong Shim, Giovanni Corso, Min-Hee Ryu, Yoon-Koo Kang, Franco Roviello, Gordon Saksena, Shouyong Peng, Ramesh A Shivdasani, Adam J Bass, Rameen Beroukhim
Gastric cancer, a leading worldwide cause of cancer mortality, shows high geographic and ethnic variation in incidence rates, which are highest in East Asia. The anatomic locations and clinical behavior also differ by geography, leading to the controversial idea that Eastern and Western forms of the disease are distinct. In view of these differences, we investigated whether gastric cancers from Eastern and Western patients show distinct genomic profiles. We used high-density profiling of somatic copy-number aberrations to analyze the largest collection to date of gastric adenocarcinomas and utilized genotyping data to rigorously annotate ethnic status...
2017: PloS One
https://www.readbyqxmd.com/read/28425617/some-posterior-branches-of-extralaryngeal-recurrent-laryngeal-nerves-have-motor-fibers
#2
Ilyoung Cho, Min-Gyu Jo, Sung-Won Choi, Jeon Yeob Jang, Soo-Geun Wang, Wonjae Cha
OBJECTIVES/HYPOTHESIS: Anatomical variations of the recurrent laryngeal nerve (RLN), such as extralaryngeal branching, are a well-known risk factor for RLN injury during thyroid surgery. This study aimed to analyze the surgical anatomy and to investigate the existence of posterior branch motor fibers of extralaryngeal RLNs. STUDY DESIGN: Prospective consecutive observational study. METHODS: This was a prospective cohort study of 366 patients between January 2014 and February 2016...
April 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28421658/transcriptional-signatures-of-connectomic-subregions-of-the-human-striatum
#3
Linden Parkes, Ben Fulcher, Murat Yücel, Alex Fornito
Functionally distinct regions of the brain are thought to possess a characteristic connectional fingerprint - a profile of incoming and outgoing connections that defines the function of that area. This observation has motivated efforts to subdivide brain areas using their connectivity patterns. However, it remains unclear whether these connectomically-defined subregions can be distinguished at the molecular level. Here, we combine high-resolution diffusion-weighted magnetic resonance imaging with transcriptomic data to show that connectomically-defined subregions of the striatum carry distinct transcriptional signatures...
April 19, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28419852/reliability-of-volumetric-and-surface-based-normalisation-and-smoothing-techniques-for-pet-analysis-of-the-cortex-a-test-retest-analysis-using-11-c-sch-23390
#4
Granville J Matheson, Per Stenkrona, Zsolt Cselényi, Pontus Plavén-Sigray, Christer Halldin, Lars Farde, Simon Cervenka
Parametric voxelwise analysis is a commonly used tool in neuroimaging, as it allows for identification of regions of effects in the absence of a strong a-priori regional hypothesis by comparing each voxel of the brain independently. Due to the inherent imprecision of single voxel measurements, spatial smoothing is performed to increase the signal-to-noise ratio of single-voxel estimates. In addition, smoothing compensates for imprecisions in anatomical registration, and allows for the use of cluster-based statistical thresholding...
April 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/28419685/scaffolds-for-epithelial-tissue-engineering-customized-in-elastomeric-molds
#5
Mohamed-Nur Abdallah, Sara Abdollahi, Marco Laurenti, Dongdong Fang, Simon D Tran, Marta Cerruti, Faleh Tamimi
Restoration of soft tissue defects remains a challenge for surgical reconstruction. In this study, we introduce a new approach to fabricate poly(d,l-lactic acid) (PDLLA) scaffolds with anatomical shapes customized to regenerate three-dimensional soft tissue defects. Highly concentrated polymer/salt mixtures were molded in flexible polyether molds. Microcomputed tomography showed that with this approach it was possible to produce scaffolds with clinically acceptable volume ratio maintenance (>90%). Moreover, this technique allowed us to customize the average pore size and pore interconnectivity of the scaffolds by using variations of salt particle size...
April 18, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28419340/extremely-thick-cell-walls-and-low-mesophyll-conductance-welcome-to-the-world-of-ancient-living
#6
Linda-Liisa Veromann-Jürgenson, Tiina Tosens, Lauri Laanisto, Ülo Niinemets
Mesophyll conductance is thought to be an important photosynthetic limitation in gymnosperms, but they currently constitute the most understudied plant group in regard to the extent to which photosynthesis and intrinsic water use efficiency are limited by mesophyll conductance. A comprehensive analysis of leaf gas exchange, photosynthetic limitations, mesophyll conductance (calculated by three methods previously used for across-species comparisons), and the underlying ultra-anatomical, morphological and chemical traits in 11 gymnosperm species varying in evolutionary history was performed to gain insight into the evolution of structural and physiological controls on photosynthesis at the lower return end of the leaf economics spectrum...
April 13, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28417660/anatomic-characteristics-identification-and-protection-of-the-nonrecurrent-laryngeal-nerve-during-thyroidectomy
#7
Na Qiao, Lin-Feng Wu, Wei Gao, Feng-Zhi Qu, Peng-Yu Duan, Cheng-Liang Cao, Pan-Quan Li, Bei Sun, Gang Wang
Objective We aimed to investigate the anatomical features and variation pattern of the nonrecurrent laryngeal nerve (NRLN), summarize the methods for identifying the NRLN before and during thyroidectomy, and share experiences regarding preventing and treating its injury. Study Design Retrospective case data analysis. Setting First Affiliated Hospital of Harbin Medical University. Subjects and Methods Between January 2002 and May 2016, 7392 patients underwent thyroidectomy in our hospital. Of them, 28 patients with NRLN were identified, and their clinical data were retrospectively analyzed...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28417223/dorsal-metacarpal-veins-anatomic-variation-and-potential-clinical-implications
#8
Sara S Elmegarhi, Justin Z Amarin, Maher T Hadidi, Darwish H Badran, Islam M Massad, Amjad M Bani-Hani, Amjad T Shatarat
The dorsal metacarpal veins are frequently cannulated. Cannulation success is determined by several variable anatomic features. The objective of this study is to classify, for the first time, the anatomic variants of the dorsal metacarpal veins. In this cross-sectional study, 520 university students and staff were conveniently recruited. The dorsal metacarpal veins in 1040 hands were studied. Venous visibility was enhanced by either tourniquet application or near-infrared illumination. Variant patterns of the dorsal metacarpal veins were classified...
April 17, 2017: Anatomical Science International
https://www.readbyqxmd.com/read/28417040/unusual-branching-pattern-of-the-lateral-cord-of-the-brachial-plexus-associated-with-neurovascular-compression-case-report
#9
Hitendra K Loh, Shikha Singh, Rajesh K Suri
The brachial plexus consists of a network of nerves that innervates the upper limbs and its musculature. We report a rare formation of the lateral cord of the brachial plexus observed during the dissection of a 47-year-old male cadaver at the Department of Anatomy, Vardhman Mahavir Medical College, New Delhi, India, in 2016. The lateral cord was exceptionally long with twin lateral pectoral nerves and twin lateral roots of the median nerve. The proximal lateral root of the median nerve was thin in comparison to the medial root of the median nerve...
February 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28415897/electric-field-navigated-transcranial-magnetic-stimulation-for-chronic-tinnitus-a-randomized-placebo-controlled-study
#10
Hanna Sahlsten, Juuso Virtanen, Juho Joutsa, Katri Niinivirta-Joutsa, Eliisa Löyttyniemi, Reijo Johansson, Janika Paavola, Tero Taiminen, Noora Sjösten, Jaakko Salonen, Anu Holm, Esa Rauhala, Satu K Jääskeläinen
OBJECTIVE: Repetitive transcranial magnetic stimulation (rTMS) may alleviate tinnitus. We evaluated effects of electric field (E-field) navigated rTMS targeted according to tinnitus pitch. No controlled studies have investigated anatomically accurate E-field-rTMS for tinnitus. DESIGN: Effects of E-field-rTMS were evaluated in a prospective randomised placebo-controlled 6-month follow-up study on parallel groups. Patients received 10 sessions of 1 Hz rTMS or placebo targeted to the left auditory cortex corresponding to tonotopic representation of tinnitus pitch...
April 18, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28413377/mimicry-of-appendicitis-symptomatology-in-congenital-anomalies-and-diseases-of-the-genitourinary-system-and-pregnancy
#11
REVIEW
Amanda Dalpiaz, Jason Gandhi, Noel L Smith, Gautam Dagur, Richard Schwamb, Steven J Weissbart, Sardar Ali Khan
INTRODUCTION: Appendicitis is a prevailing cause of acute abdomen, but is often difficult to diagnose due to its wide range of symptoms, anatomical variations, and developmental abnormalities. Urological disorders of the genitourinary tract may be closely related to appendicitis due to the close proximity of the appendix to the genitourinary tract. This review provides a summary of the urological complications and simulations of appendicitis. Both typical and urological symptoms of appendicitis are discussed, as well as recommended diagnostic and treatment methods...
January 2017: Current Urology
https://www.readbyqxmd.com/read/28412828/magnetic-resonance-angiographic-study-of-anatomic-variations-of-the-circle-of-willis-in-a-population-in-tehran
#12
Bahman Jalali Kondori, Fateme Azemati, Sonia Dadseresht
BACKGROUND AND OBJECTIVES: The circle of Willis, an anastomotic polygon at the base of the brain, forms an important collateral network to maintain cerebral blood perfusion. The aim of this study was to investigate different anatomic variations of the circle of Willis and their prevalence. METHODS: This cross-sectional study was conducted on 525 healthy participants including 205 men and 320 women. The mean age of the patients was 51.5 years. Three-dimensional time-of-flight magnetic resonance angiography (3D-TOF MRA) technique was used...
April 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28411321/endoscopic-colloid-cyst-excision-surgical-techniques-and-nuances
#13
Waleed Abdelfattah Azab, Mustafa Najibullah, Waleed Yosef
BACKGROUND: Endoscopic excision of colloid cysts is currently well established as a minimally invasive and highly effective technique that is associated with less morbidity in comparison to microsurgical resection. METHODS: Operative charts and videos of patients undergoing endoscopic colloid cyst excision were retrieved from the senior author's database of endoscopic procedures and reviewed. This revealed nine trans-foraminal and three trans-septal procedures. Description of the surgical techniques was then formulated...
April 14, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28409316/mental-foramen-and-lingual-vascular-canals-of-mandible-on-mdct-images-anatomical-study-and-review-of-the-literature
#14
Filiz Direk, Ismihan Ilknur Uysal, Ali Sami Kivrak, Zeliha Fazliogullari, Nadire Unver Dogan, Ahmet Kagan Karabulut
The mental foramen and lingual vascular canals are related to vessels and nerves in the mandibular body. The aim of the present study was to determine the number and location of these structures and to make measurements of them. The archived Multidetector Computed Tomography images of 100 adult (15- to 70-year-old) patients were evaluated retrospectively. The diameters of the mental foramens and their distances from the front, back, upper and lower reference points were measured. The distribution of mental foramens with respect to the teeth was also researched...
April 13, 2017: Anatomical Science International
https://www.readbyqxmd.com/read/28409134/anatomical-variations-of-pronator-teres-muscle-predispositional-role-for-nerve-entrapment
#15
Edie Benedito Caetano, Luiz Ângelo Vieira, Fábio Antonio Anversa Sprovieri, Guilherme Camargo Petta, Maurício Tadeu Nakasone, Bárbara Lívia Correa Serafim
OBJECTIVE: To assess the anatomical variations of the pronator teres muscle (PTM) and its implication in the compression of the median nerve, which passes through the humeral and ulnar heads of the PTM. METHODS: For the present study, 100 upper limbs from human cadavers from the anatomy laboratory were dissected. Forty-six specimens were male and four, female, whose aged ranged from 28 to 77 years; 27 were white and 23, non-white. A pilot study consisting of six hands from three fresh cadaver dissections was conducted to familiarize the authors with the local anatomy; these were not included in the present study...
March 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28406557/determinants-of-iliac-blade-orientation-in-anthropoid-primates
#16
Emily R Middleton, Zachariah J Winkler, Ashley S Hammond, J Michael Plavcan, Carol V Ward
Orientation of the iliac blades is a key feature that appears to distinguish extant apes from monkeys. Iliac morphology is hypothesized to reflect variation in thoracic shape that, in turn, reflects adaptations for shoulder and forearm function in anthropoids. Iliac orientation is traditionally measured relative to the acetabulum, whereas functional explanations pertain to its orientation relative to the cardinal anatomical planes. We investigated iliac orientation relative to a median plane using digital models of hipbones registered to landmark data from articulated pelves...
May 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28406379/the-neural-basis-of-independence-versus-interdependence-orientations-a-voxel-based-morphometric-analysis-of-brain-volume
#17
Fei Wang, Kaiping Peng, Magdalena Chechlacz, Glyn W Humphreys, Jie Sui
Sociocultural research has established independence and interdependence as two fundamental ways of thinking about oneself and the social world. Recent neuroscience studies further demonstrate that these orientations modulate brain activity in various self- and socially related tasks. In the current study, we explored whether the traits of independence and interdependence are reflected in anatomical variations in brain structure. We carried out structural brain imaging on a large sample of healthy participants ( n = 265) who also completed self-report questionnaires of cultural orientations...
April 2017: Psychological Science
https://www.readbyqxmd.com/read/28405888/effects-of-common-grm5-genetic-variants-on-cognition-hippocampal-volume-and-mglur5-protein-levels-in-schizophrenia
#18
Natalie Matosin, Kelly Anne Newell, Yann Quidé, Jessica Lee Andrews, Nina Teroganova, Melissa Jayne Green, Francesca Fernandez
GRM5 (coding for metabotropic glutamate receptor 5, mGluR5) is a promising target for the treatment of cognitive deficits in schizophrenia, but there has been little investigation of its association with cognitive and brain phenotypes within this disorder. We examined the effects of common genetic variation in GRM5 with cognitive function, hippocampal volume, and hippocampal mGluR5 protein levels in schizophrenia patients relative to healthy controls. Two independent GRM5 variants rs60954128 [C>T] and rs3824927 [G>T] were genotyped in a schizophrenia case/control cohort (n=249/261)...
April 13, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28405730/sex-related-variations-in-cortical-and-trabecular-bone-of-the-femoral-neck-in-an-elderly-chinese-population
#19
L Wang, X G Cheng, Y B Su, K Brown, L Xu, K Li, C X Zhang, Y Zhang, Y Y Duanmu, X B Wu, M Y Wang
Quantitative computed tomography (QCT) was used to investigate sex-related variations in cortical and trabecular bone of the femoral neck. Cortical bone thickness of women in the superior quadrant was thinner than that of men, and the cortex in all four quadrants was negatively associated with age in women. INTRODUCTION: This cross-sectional study aimed to investigate sex-related similarities and differences in femoral neck structure in an elderly Chinese population by QCT bone investigational toolkit (BIT) analysis...
April 12, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28401028/coexistence-of-right-nonrecurrent-nerve-and-bifurcated-recurrent-laryngeal-nerve-pointed-by-zuckerkandl-s-tubercle
#20
Emin Gurleyik, Sami Dogan, Fuat Cetin
The recurrent laryngeal nerve (RLN) has many anatomical variations and various relations with adjacent structures. Identification and total exposure of the cervical part of the RLN was performed during operations on the thyroid gland. An extremely rare anatomical variation of the nerve was encountered during the surgical procedure. Coexistence of both right RLN and non-RLN was observed in one patient surgically treated with total thyroidectomy. We first exposed the right RLN with an extralaryngeal terminal bifurcation at its usual position...
March 5, 2017: Curēus
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