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https://www.readbyqxmd.com/read/28503880/individualised-medicine-why-we-need-bayesian-dosing
#1
Joni Donagher, Jennifer H Martin, Michael A Barras
Individualised drug dosing has been shown to improve patient outcomes and reduce adverse drug events. One method of individualised medicine is the Bayesian approach, which uses prior information about how the population responds to therapy, to inform clinicians about how a specific individual is responding to their current therapy. This information is then used to make changes to the dose. Studies using a Bayesian approach to adjust drug dosing have shown that clinicians are able to achieve a therapeutic range quicker than standard practice...
May 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28479694/emperipolesis-entosis-and-cell-cannibalism-demystifying-the-cloud
#2
REVIEW
Nidhi Gupta, Kiran Jadhav, Vandana Shah
There are intense published data in literature related to cell engulfment phenomena such as emperipolesis, entosis and cell cannibalism. All these are closely related phenomena with a very fine line of differences. Its correct identification has a significant diagnostic and prognostic value. After extensive literature search, a gap of knowledge was found in concept designing and clarity about understanding of aforementioned terminologies. The authors have attempted to review data of these closely knit terminologies and further organize its characteristic appearances, pathogenetic aspects and prognostic implications...
January 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28460959/bioactive-peptides-derived-from-traditional-chinese-medicine-and-traditional-chinese-food-a-review
#3
REVIEW
Ming Liu, Yunpu Wang, Yuhuan Liu, Roger Ruan
There is an urgent treat of numerous chronic diseases including heart disease, stroke, cancer, chronic respiratory diseases and diabetes, which have a significant influence on the health of people worldwide. In addition to numerous preventive and therapeutic drug treatments, important advances have been achieved in the identification of bioactive peptides that may contribute to long-term health. Although bioactive peptides with various biological activities received unprecedented attention, as a new source of bioactive peptides, the significant role of bioactive peptides from traditional Chinese medicine and traditional Chinese food has not fully appreciated compared to other bioactive components...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28444398/plasma-transfusion-demystified-a-review-of-the-key-factors-influencing-the-response-to-plasma-transfusion
#4
Allen W Bryan, Elizabeth M Staley, Timothy Kennell, Alexander Z Feldman, Lance A Williams, Huy P Pham
Many studies have suggested that inappropriate plasma usage is common. An important factor contributing to futile plasma administration in most patients is the nonlinear relationship between coagulation-factor levels and the volume of plasma transfused. In this review, a validated mathematical model and data from the literature will be used to illuminate 3 key properties of plasma transfusion. Those properties are as follows: the effect of plasma transfusion on international normalized ratio (INR) is transient; for the same volume of transfused plasma, a greater reduction in INR is observed at higher initial INRs; and the effect of plasma transfusion on INR correction (ie, the difference between initial and final INRs) diminishes as more plasma is transfused...
May 1, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28442979/-anesthesia-bubbles-demystifying-the-enigma
#5
Dheeraj Kapoor, Ankur Dhal, Jasveer Singh, Manpreet Singh
No abstract text is available yet for this article.
April 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28430540/demystifying-orbital-emergencies-a-pictorial-review
#6
Viet D Nguyen, Achint K Singh, Wilson B Altmeyer, Bundhit Tantiwongkosi
Imaging of the orbit plays an important role in the workup of orbital emergencies. Orbital imaging is particularly useful in the emergency department, where clinical history and physical examination may be limited or delayed until the exclusion or treatment of more life-threatening conditions. Cross-sectional orbital imaging with multidetector computed tomography (CT) and magnetic resonance (MR) imaging is commonly performed in addition to ultrasonography. In an emergent setting, CT is the preferred modality when evaluating for intraorbital foreign bodies, fractures, or calcifications within a mass lesion...
May 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28430452/demystifying-complex-quantum-dot-heterostructures-using-photogenerated-charge-carriers
#7
G Krishnamurthy Grandhi, Ranjani Viswanatha
The success of heterostructure quantum dots in optoelectronic and photovoltaic applications is based on our understanding of photogenerated charge carrier localization. However, often the actual location of charge carriers in heterostructure semiconductors is quite different from their predicted positions leading to suboptimal results. In this work, photoluminescence of Cu doped heterostructures has been used to study the charge localization of alloys, inverse type I, type II, and quasi type II core/shell structures and graded alloys...
May 4, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28410047/demystifying-research-it-s-for-everyone
#8
Sam Foster
Sam Foster, Chief Nurse at Heart of England NHS Foundation Trust, explains how practical guidance is now available to help all nurses-including those starting their careers on the frontline-to contribute to research.
April 13, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28407144/the-north-american-primary-care-research-group-s-patient-and-clinician-engagement-program-pace-demystifying-patient-engagement-through-a-dyad-model
#9
Jessica Sand, Maret Felzien, Ray Haeme, Hazel Tapp, Diane Derkowski, John M Westfall
Background.: Community engagement in research is essential for translating the best evidence into community and clinical practice to improve the health and well-being of the population. Objective.: North American Primary Care Research Group's Patient and Clinician Engagement Program (PaCE) program aims to develop a robust community of patients and primary care providers with knowledge and understanding of the unique features of patient-centred outcomes research related to primary care in order to advocate for and engage in research...
June 1, 2017: Family Practice
https://www.readbyqxmd.com/read/28398970/demystifying-intention-to-treat-analyses
#10
Catalin Tufanaru
No abstract text is available yet for this article.
April 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28395857/investigations-of-the-hofmeister-series-and-other-specific-ion-effects-using-lipid-model-systems
#11
REVIEW
Epameinondas Leontidis
From the ion point-of-view specific ion effects (SIE) arise as an interplay of ionic size and shape and charge distribution. However in aqueous systems SIE invariably involve water, and at surfaces they involve both interacting surface groups and local fields emanating from the surface. In this review we highlight the fundamental importance of ionic size and hydration on SIE, properties which encompass all types of interacting forces and ion-pairing phenomena and make the Hofmeister or lyotropic series of ions pertinent to a broad range of systems and phenomena...
April 4, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28393387/dental-students-reflections-about-long-term-care-experiences-through-an-existing-model-of-oral-health
#12
Mario Brondani, Komkham Pattanaporn
OBJECTIVE: The aim of this study was to explore students' reflective thinking about long-term care experiences from the perspective of a model of oral health. MATERIALS AND METHODS: A total of 186 reflections from 193 second-year undergraduate dental students enrolled between 2011/12 and 2014/15 at the University of British Columbia were explored qualitatively. Reflections had a word limit of 300, and students were asked to relate an existing model of oral health to their long-term care experiences...
April 10, 2017: Gerodontology
https://www.readbyqxmd.com/read/28392725/demystifying-eqa-statistics-and-reports
#13
REVIEW
Wim Coucke, Mohamed Rida Soumali
Reports act as an important feedback tool in External Quality Assessment (EQA). Their main role is to score laboratories for their performance in an EQA round. The most common scores that apply to quantitative data are Q- and Z-scores. To calculate these scores, EQA providers need to have an assigned value and standard deviation for the sample. Both assigned values and standard deviations can be derived chemically or statistically. When derived statistically, different anomalies against the normal distribution of the data have to be handled...
February 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28383023/demystifying-rotors-and-their-place-in-clinical-translation-of-atrial-fibrillation-mechanisms
#14
REVIEW
Stanley Nattel, Feng Xiong, Martin Aguilar
Treatment of atrial fibrillation (AF), the most common arrhythmia in clinical practice, remains challenging. Improved understanding of underlying mechanisms is needed to improve therapy. Functional re-entry is central to AF maintenance. The first detailed, quantitative theory of functional re-entry, the 'leading circle' model, was developed 40 years ago. Subsequently, an alternative paradigm based on 'spiral waves' has evolved. Spiral-wave generators, or 'rotors', have been identified using advanced mapping methods in experimental and clinical AF...
April 6, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28375404/hot-topics-in-primary-care-demystifying-the-differences-follow-on-biologics-biosimilars-and-generics
#15
REVIEW
Eugene E Wright, Thomas C Blevins, Beverly Reed, Roy Daniel Pollom
Sponsors of follow-on biologics can submit their applications for approval by the US Food and Drug Administration (FDA) under 2 distinct pathways. The submission pathway is determined by the pathway previously used by the reference biologic product, which is the biologic product upon which the follow-on product relies for evidence of safety and efficacy.
April 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28361939/demystifying-blood-stem-cell-fates
#16
Fiona K Hamey, Berthold Göttgens
Determining the differentiation potential of stem and progenitor cells is essential for understanding their function, yet our ability to do so is limited by the restrictions of experimental assays. Based on single-cell functional and molecular profiling experiments, a new computational approach shows how lineage commitment may occur in human haematopoiesis.
March 31, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28357363/metabolic-network-structure-and-function-in-bacteria-goes-beyond-conserved-enzyme-components
#17
COMMENT
Jannell V Bazurto, Diana M Downs
For decades, experimental work has laid the foundation for our understanding of the linear and branched pathways that are integrated to form the metabolic networks on which life is built. Genetic and biochemical approaches applied in model organisms generate empirical data that correlate genes, gene products and their biological activities. In the post-genomic era, these results have served as the basis for the genome annotation that is routinely used to infer the metabolic capabilities of an organism and mathematically model the presumed metabolic network structure...
April 14, 2016: Microbial Cell
https://www.readbyqxmd.com/read/28353478/demystifying-nursing-research-at-the-bedside
#18
Esther Chipps, Mary Nash, Jacalyn Buck, Brenda Vermillion
No abstract text is available yet for this article.
April 2017: Nursing Management
https://www.readbyqxmd.com/read/28340685/research-techniques-made-simple-experimental-methodology-for-single-cell-mass-cytometry
#19
Tiago R Matos, Hongye Liu, Jerome Ritz
Growing recognition of the complexity of interactions within cellular systems has fueled the development of mass cytometry. The precision of time-of-flight mass spectrometry combined with the labeling of specific ligands with mass tags enables detection and quantification of more than 40 markers at a single-cell resolution. The 135 available detection channels allow simultaneous study of additional characteristics of complex biological systems across millions of cells. Cutting-edge mass cytometry by time-of-flight (CyTOF) can profoundly affect our knowledge of cell population heterogeneity and hierarchy, cellular state, multiplexed signaling pathways, proteolysis products, and mRNA transcripts...
April 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28340651/osteotomies-demystified
#20
REVIEW
Kyle K VanKoevering, Andrew J Rosko, Jeffrey S Moyer
Osteotomies are critical techniques in rhinoplasty. There are a variety of approaches, trajectories, and tools used with no widely standardized classification or nomenclature. Percutaneous osteotomies are gaining in popularity, and picture framing the nasomaxillary bone is crucial for predictable fracture and reproducible results. This is best accomplished with medial, lateral, and transverse osteotomies. Intermediate osteotomies are used less frequently, but provide more mobility. With a detailed understanding of anatomy and a thorough approach to nasal osteotomies, the contour and function of the bony vault can be reshaped with a successful outcome for both the surgeon and patient...
May 2017: Facial Plastic Surgery Clinics of North America
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