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https://www.readbyqxmd.com/read/28807707/quality-improvement-pearls-for-the-palliative-care-and-hospice-professional
#1
Arif H Kamal, Jonathan M Nicolla, Steve Power
Rapid changes in how palliative care clinicians are evaluated and paid present an imperative for clinicians to adeptly and routinely perform quality improvement in usual practice. Like empathic communication and facilitating goals of care discussions, quality improvement skills must be learned, honed, and practiced so identifying problems and brainstorming solutions becomes a natural component of delivering serious illness care. Using our experience in both failures and successes in performing quality improvement, herein we provide a prioritized list of ten pearls specifically aimed to palliative care and hospice professionals...
August 11, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28798505/an-enactive-account-of-placebo-effects
#2
Giulio Ongaro, Dave Ward
Placebos are commonly defined as ineffective treatments. They are treatments that lack a known mechanism linking their properties to the properties of the condition on which treatment aims to intervene. Given this, the fact that placebos can have substantial therapeutic effects looks puzzling. The puzzle, we argue, arises from the relationship placebos present between culturally meaningful entities (such as treatments or therapies), our intentional relationship to the environment (such as implicit or explicit beliefs about a treatment's healing powers) and bodily effects (placebo responses)...
2017: Biology & Philosophy
https://www.readbyqxmd.com/read/28768117/cationic-surfactant-mediated-fibrillogenesis-in-bovine-liver-catalase-a-biophysical-approach
#3
MohsinVahid Khan, Masihuz Zaman, TajalliIlm Chandel, Mohammad Khursheed Siddiqui, Mohd Rehan Ajmal, Ali Saber Abdelhameed, RizwanHasan Khan
Protein aggregation into oligomers and mature fibrils are associated with more than 20 diseases in humans. The interactions between cationic surfactants dodecyltrimethylammonium bromide (DTAB) andtetradecyltrimethylammonium bromide (TTAB) with varying alkyl chain lengths and bovine liver catalase (BLC) were examined by various biophysical approaches. The delicate coordination of electrostatic and hydrophobic interactions with protein, play imperative role in aggregation. In this article we have reconnoitered the relation between charge, hydrophobicity and cationic surfactants DTAB and TTAB on BLC at pH 7...
August 2, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28758992/demystifying-traditional-herbal-medicine-with-modern-approach
#4
Fu-Shuang Li, Jing-Ke Weng
Plants have long been recognized for their therapeutic properties. For centuries, indigenous cultures around the world have used traditional herbal medicine to treat a myriad of maladies. By contrast, the rise of the modern pharmaceutical industry in the past century has been based on exploiting individual active compounds with precise modes of action. This surge has yielded highly effective drugs that are widely used in the clinic, including many plant natural products and analogues derived from these products, but has fallen short of delivering effective cures for complex human diseases with complicated causes, such as cancer, diabetes, autoimmune disorders and degenerative diseases...
July 31, 2017: Nature Plants
https://www.readbyqxmd.com/read/28758765/ptsd-mental-illness-and-care-among-survivors-of-sexual-violence-in-northern-uganda-findings-from-the-ways-study
#5
Kennedy Amone-P'Olak, Ask Elklit, Sarah Bøgelund Dokkedahl
BACKGROUND: Previous studies have mainly considered war-affected youth as a homogenous group yet several subpopulations of war-affected youth, such as survivors of sexual violence, exist with unique mental health problems and treatment needs. This study aimed to assess posttraumatic stress disorder (PTSD), perceptions and meaning of mental illness, and access and barriers to mental health care among survivors of sexual violence. METHOD: Data were collected from survivors of sexual violence during war (N = 181) who are participants in the longitudinal War-Affected Youth Survey (WAYS) study in Northern Uganda...
July 31, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28703298/introduction-to-anatomy-on-wikipedia
#6
Thomas Stephen Ledger
Wikipedia (www.wikipedia.com) is the largest encyclopaedia in existence. Of over five million English-language articles, about 6000 relate to Anatomy, which are viewed roughly 30 million times monthly. No work parallels the amount of attention, scope or interdisciplinary layout of Wikipedia, and it offers a unique opportunity to improve the anatomical literacy of the masses. Anatomy on Wikipedia is introduced from an editor's perspective. Article contributors, content, layout and accuracy are discussed, with a view to demystifying editing for anatomy professionals...
July 12, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28694022/the-clinical-utility-of-repetitive-transcranial-magnetic-stimulation-in-reducing-the-risks-of-transitioning-from-acute-to-chronic-pain-in-traumatically-injured-patients
#7
REVIEW
Marianne Jodoin, Dominique Rouleau, Camille Larson-Dupuis, Nadia Gosselin, Louis De Beaumont
Pain is a multifaceted condition and a major ongoing challenge for healthcare professionals having to treat patients in whom pain put them at risk of developing other conditions. Significant efforts have been invested in both clinical and research settings in an attempt to demystify the mechanisms at stake and develop optimal treatments as well as to reduce individual and societal costs. It is now universally accepted that neuroinflammation and central sensitization are two key underlying factors causing pain chronification as they result from maladaptive central nervous system plasticity...
July 7, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28663164/assessing-user-engagement-of-an-mhealth-intervention-development-and-implementation-of-the-growing-healthy-app-engagement-index
#8
Sarah Taki, Sharyn Lymer, Catherine Georgina Russell, Karen Campbell, Rachel Laws, Kok-Leong Ong, Rosalind Elliott, Elizabeth Denney-Wilson
BACKGROUND: Childhood obesity is an ongoing problem in developed countries that needs targeted prevention in the youngest age groups. Children in socioeconomically disadvantaged families are most at risk. Mobile health (mHealth) interventions offer a potential route to target these families because of its relatively low cost and high reach. The Growing healthy program was developed to provide evidence-based information on infant feeding from birth to 9 months via app or website. Understanding user engagement with these media is vital to developing successful interventions...
June 29, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28648436/angiotensin-converting-enzyme-inhibitors-and-receptor-blockers-in-heart-failure-and-chronic-kidney-disease-demystifying-controversies
#9
REVIEW
Kader Muneer, Anishkumar Nair
In clinical setting, congestive heart failure (CHF) and chronic kidney disease (CKD) often co-exist in patients due to common underlying predisposing factors. An intricate equilibrium between the cardiovascular and renal system is maintained through rennin angiotensin-aldosterone axis and autonomic nervous system. Consequent to favorable hemodynamic modification, angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blocking (ARB) therapy have proven to be an indispensable aspect of heart failure management with morbidity and mortality benefit...
May 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28617233/demystifying-the-publication-process
#10
Jennifer Zelmer
No abstract text is available yet for this article.
May 2017: Healthcare Policy, Politiques de Santé
https://www.readbyqxmd.com/read/28607773/fto-gene-associates-and-interacts-with-obesity-risk-physical-activity-energy-intake-and-time-spent-sitting-pilot-study-in-a-nigerian-population
#11
Bolaji Fatai Oyeyemi, Charles Ayorinde Ologunde, Ayonposi Bukola Olaoye, Nanfizat Abiket Alamukii
Fat mass and obesity-associated (FTO) gene influences obesity but studies have shown that environmental/lifestyle variables like physical activity (PA), time spent sitting (TSS), and energy intake might mediate the effect. However, this is poorly understood in Nigeria due to scarce studies. We demystified association and interaction between FTO rs9939609, obesity, PA, TSS, and energy intake in Nigeria. FTO gene variant was genotyped by restriction fragment length polymorphism and gene sequencing analysis in 103 people with obesity and 98 controls...
2017: Journal of Obesity
https://www.readbyqxmd.com/read/28578328/gene-and-cell-doping-the-new-frontier-beyond-myth-or-reality
#12
Elmo W I Neuberger, Perikles Simon
The advent of gene transfer technologies in clinical studies aroused concerns that these technologies will be misused for performance-enhancing purposes in sports. However, during the last 2 decades, the field of gene therapy has taken a long and winding road with just a few gene therapeutic drugs demonstrating clinical benefits in humans. The current state of gene therapy is that viral vector-mediated gene transfer shows the now long-awaited initial success for safe, and in some cases efficient, gene transfer in clinical trials...
2017: Medicine and Sport Science
https://www.readbyqxmd.com/read/28571276/demystifying-the-mysteries-sexual-dimorphism-in-primary-teeth
#13
Akshara Singh, Hind Pal Bhatia, Shveta Sood, Naresh Sharma
INTRODUCTION: One of the critical steps in the process of identification is the sex determination of an unknown individual. Many studies have shown that sex can be determined using the human skeleton, especially by examining the pelvis and skull. Odontometric analysis of the human sexual variation has been less investigated, especially of primary dentition. AIM: To verify the presence of sexual dimorphism in primary teeth of local population of Faridabad, Haryana, India...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28562616/demystifying-the-capitella-capitata-complex-annelida-capitellidae-diversity-by-morphological-and-molecular-data-along-the-brazilian-coast
#14
Camila F Silva, Victor C Seixas, Rômulo Barroso, Maikon Di Domenico, Antonia C Z Amaral, Paulo C Paiva
The sibling species of Capitella capitata are globally known for their tolerance to disturbed habitats and the C. capitata complex is often used as an ecological indicator. A recent re-description proposed that C. capitata, originally described in Greenland is restricted to the Artic and Subarctic regions. Given their ecological relevance, we conducted a morphological and molecular analyses based on mtDNA sequences to investigate the diversity and distribution of the C. capitata complex along the Brazilian coast...
2017: PloS One
https://www.readbyqxmd.com/read/28533294/type-2-diabetes-demystifying-the-global-epidemic
#15
Ranjit Unnikrishnan, Rajendra Pradeepa, Shashank R Joshi, Viswanathan Mohan
Type 2 diabetes (T2D) has attained the status of a global pandemic, spreading from affluent industrialized nations to the emerging economies of Asia, Latin America, and Africa. There is significant global variation in susceptibility to T2D, with Pacific Islanders, Asian Indians, and Native Americans being considerably more prone to develop the disorder. Although genetic factors may play a part, the rapidity with which diabetes prevalence has risen among these populations reflects the far-ranging and rapid socioeconomic changes to which they have been exposed over the past few decades...
June 2017: Diabetes
https://www.readbyqxmd.com/read/28529698/seven-perspectives-on-gpcr-h-d-exchange-proteomics-methods
#16
Xi Zhang
Recent research shows surging interest to visualize human G protein-coupled receptor (GPCR) dynamic structures using the bottom-up H/D-exchange (HDX) proteomics technology. This opinion article clarifies critical technical nuances and logical thinking behind the GPCR HDX proteomics method, to help scientists overcome cross-discipline pitfalls, and understand and reproduce the protocol at high quality. The 2010 89% HDX structural coverage of GPCR was achieved with both structural and analytical rigor. This article emphasizes systematically considering membrane protein structure stability and compatibility with chromatography and mass spectrometry (MS) throughout the pipeline, including the effects of metal ions, zero-detergent shock, and freeze-thaws on HDX result rigor...
2017: F1000Research
https://www.readbyqxmd.com/read/28503880/individualised-medicine-why-we-need-bayesian-dosing
#17
Joni Donagher, Jennifer H Martin, Michael A Barras
Individualised drug dosing has been shown to improve patient outcomes and reduce adverse drug events. One method of individualised medicine is the Bayesian approach, which uses prior information about how the population responds to therapy, to inform clinicians about how a specific individual is responding to their current therapy. This information is then used to make changes to the dose. Studies using a Bayesian approach to adjust drug dosing have shown that clinicians are able to achieve a therapeutic range quicker than standard practice...
May 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28479694/emperipolesis-entosis-and-cell-cannibalism-demystifying-the-cloud
#18
REVIEW
Nidhi Gupta, Kiran Jadhav, Vandana Shah
There are intense published data in literature related to cell engulfment phenomena such as emperipolesis, entosis and cell cannibalism. All these are closely related phenomena with a very fine line of differences. Its correct identification has a significant diagnostic and prognostic value. After extensive literature search, a gap of knowledge was found in concept designing and clarity about understanding of aforementioned terminologies. The authors have attempted to review data of these closely knit terminologies and further organize its characteristic appearances, pathogenetic aspects and prognostic implications...
January 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28460959/bioactive-peptides-derived-from-traditional-chinese-medicine-and-traditional-chinese-food-a-review
#19
REVIEW
Ming Liu, Yunpu Wang, Yuhuan Liu, Roger Ruan
There is an urgent treat of numerous chronic diseases including heart disease, stroke, cancer, chronic respiratory diseases and diabetes, which have a significant influence on the health of people worldwide. In addition to numerous preventive and therapeutic drug treatments, important advances have been achieved in the identification of bioactive peptides that may contribute to long-term health. Although bioactive peptides with various biological activities received unprecedented attention, as a new source of bioactive peptides, the significant role of bioactive peptides from traditional Chinese medicine and traditional Chinese food has not fully appreciated compared to other bioactive components...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28444398/plasma-transfusion-demystified-a-review-of-the-key-factors-influencing-the-response-to-plasma-transfusion
#20
Allen W Bryan, Elizabeth M Staley, Timothy Kennell, Alexander Z Feldman, Lance A Williams, Huy P Pham
Many studies have suggested that inappropriate plasma usage is common. An important factor contributing to futile plasma administration in most patients is the nonlinear relationship between coagulation-factor levels and the volume of plasma transfused. In this review, a validated mathematical model and data from the literature will be used to illuminate 3 key properties of plasma transfusion. Those properties are as follows: the effect of plasma transfusion on international normalized ratio (INR) is transient; for the same volume of transfused plasma, a greater reduction in INR is observed at higher initial INRs; and the effect of plasma transfusion on INR correction (ie, the difference between initial and final INRs) diminishes as more plasma is transfused...
May 1, 2017: Laboratory Medicine
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