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https://www.readbyqxmd.com/read/29029663/demystifying-probiotics-use-in-the-elderly
#1
Caren McHenry Martin, Gianna Bryan
Pharmacists and other health care professionals can be perplexed by the growing body of literature regarding the use of probiotics for a variety of symptoms and conditions and by an increasing number of probiotic products available to consumers. Understanding the functions of the intestinal microbiome, the possible mechanisms of actions of probiotics, the research supporting or refuting probiotic use, and criteria for selecting a probiotic product is essential to making a rational recommendation for patients...
August 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28983203/enhancing-the-research-and-publication-efforts-of-health-sciences-librarians-via-an-academic-writing-retreat
#2
John W Bullion, Stewart M Brower
BACKGROUND: This case study describes the South Central Chapter of the Medical Library Association (SCC/MLA) initiative to develop an academic writing retreat for members who sought the necessary time and support to advance their research projects toward publication. CASE PRESENTATION: SCC/MLA staged a dedicated writing retreat to coincide with the organization's 2012, 2013, and 2014 annual meetings. Each cohort met over two days to write and to workshop their peers' manuscripts...
October 2017: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/28961982/rapid-evolution-of-genes-involved-in-learning-and-energy-metabolism-for-domestication-of-the-laboratory-rat
#3
Lin Zeng, Chen Ming, Yan Li, Ling-Yan Su, Yan-Hua Su, Newton O Otecko, He-Qun Liu, Ming-Shan Wang, Yong-Gang Yao, Hai-Peng Li, Dong-Dong Wu, Ya-Ping Zhang
The laboratory rat, widely used in biomedical research, is domesticated from wild brown rat. The origin and genetic mechanism underlying domestication of the laboratory rat remain largely elusive. In the present study, large scale genomes supported a single origin for the laboratory rat, possibly from a sister group to wild rats from Europe/Africa/Middle East. Genomic and transcriptomic analyses uncovered many artificially selected genes (e.g. FOXP2, B3GAT1, and CLOCK) involved in the nervous system. These genes associate with learning ability and regulation of circadian rhythm, which likely enabled the successful domestication of the laboratory rat...
September 12, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28938360/implant-porosity-and-the-foreign-body-response
#4
Sumanas W Jordan, Jennifer E Fligor, Lindsay E Janes, Gregory A Dumanian
The biocompatibility of prosthetic mesh is dependent on a number of physicochemical properties that ultimately incite an optimal foreign body response (FBR). The magnitude and character of the FBR directly affect the clinical success of the hernia repair, with too little scar resulting in bulge or hernia recurrence and too much scar causing mesh wrinkling and pain. Moreover, it is important to consider the effect of a sustained FBR and scar remodeling on the combined strength of the mesh-tissue construct over time...
September 15, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28886352/benchmarking-an-effective-tool-to-demystify-the-academic-career
#5
Gino Inverso, John R Zuniga, Neeraj H Panchal
No abstract text is available yet for this article.
August 12, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28873882/not-just-the-right-to-a-wheelchair-but-the-right-wheelchair-improving-brazilian-wheelchair-service-delivery
#6
Tulio Maximo, Laurence Clift
This paper discusses the barriers encountered before and after the implementation of good practice in the delivery of wheelchair provision services in Belo Horizonte city, Brazil. The results demystify some participants' initial idea that using an assessment form might take significantly more time. Major barriers to implementation had regard to the assessment of pressure sores and a lack of wheelchair suppliers.
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28872869/demystifying-multitask-deep-neural-networks-for-quantitative-structure-activity-relationships
#7
Yuting Xu, Junshui Ma, Andy Liaw, Robert P Sheridan, Vladimir Svetnik
Deep neural networks (DNNs) are complex computational models that have found great success in many artificial intelligence applications, such as computer vision1,2 and natural language processing.3,4 In the past four years, DNNs have also generated promising results for quantitative structure-activity relationship (QSAR) tasks.5,6 Previous work showed that DNNs can routinely make better predictions than traditional methods, such as random forests, on a diverse collection of QSAR data sets. It was also found that multitask DNN models-those trained on and predicting multiple QSAR properties simultaneously-outperform DNNs trained separately on the individual data sets in many, but not all, tasks...
October 2, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28851684/demystifying-a-thickened-and-calcified-gall-bladder-in-the-era-of-multimodality-imaging
#8
Su Kah Goh, Anthony Upton, Christopher Christophi, Vijayaragavan Muralidharan
No abstract text is available yet for this article.
August 29, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28807707/quality-improvement-pearls-for-the-palliative-care-and-hospice-professional
#9
Arif H Kamal, Jonathan M Nicolla, Steve Power
Rapid changes in how palliative care clinicians are evaluated and paid present an imperative for clinicians to adeptly and routinely perform quality improvement in usual practice. Like empathic communication and facilitating goals of care discussions, quality improvement skills must be learned, honed, and practiced so identifying problems and brainstorming solutions becomes a natural component of delivering serious illness care. Using our experience in both failures and successes in performing quality improvement, herein we provide a prioritized list of ten pearls specifically aimed to palliative care and hospice professionals...
August 11, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28798505/an-enactive-account-of-placebo-effects
#10
Giulio Ongaro, Dave Ward
Placebos are commonly defined as ineffective treatments. They are treatments that lack a known mechanism linking their properties to the properties of the condition on which treatment aims to intervene. Given this, the fact that placebos can have substantial therapeutic effects looks puzzling. The puzzle, we argue, arises from the relationship placebos present between culturally meaningful entities (such as treatments or therapies), our intentional relationship to the environment (such as implicit or explicit beliefs about a treatment's healing powers) and bodily effects (placebo responses)...
2017: Biology & Philosophy
https://www.readbyqxmd.com/read/28768117/cationic-surfactant-mediated-fibrillogenesis-in-bovine-liver-catalase-a-biophysical-approach
#11
MohsinVahid Khan, Masihuz Zaman, TajalliIlm Chandel, Mohammad Khursheed Siddiqui, Mohd Rehan Ajmal, Ali Saber Abdelhameed, RizwanHasan Khan
Protein aggregation into oligomers and mature fibrils are associated with more than 20 diseases in humans. The interactions between cationic surfactants dodecyltrimethylammonium bromide (DTAB) andtetradecyltrimethylammonium bromide (TTAB) with varying alkyl chain lengths and bovine liver catalase (BLC) were examined by various biophysical approaches. The delicate coordination of electrostatic and hydrophobic interactions with protein, play imperative role in aggregation. In this article we have reconnoitered the relation between charge, hydrophobicity and cationic surfactants DTAB and TTAB on BLC at pH 7...
August 2, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28758992/demystifying-traditional-herbal-medicine-with-modern-approach
#12
Fu-Shuang Li, Jing-Ke Weng
Plants have long been recognized for their therapeutic properties. For centuries, indigenous cultures around the world have used traditional herbal medicine to treat a myriad of maladies. By contrast, the rise of the modern pharmaceutical industry in the past century has been based on exploiting individual active compounds with precise modes of action. This surge has yielded highly effective drugs that are widely used in the clinic, including many plant natural products and analogues derived from these products, but has fallen short of delivering effective cures for complex human diseases with complicated causes, such as cancer, diabetes, autoimmune disorders and degenerative diseases...
July 31, 2017: Nature Plants
https://www.readbyqxmd.com/read/28758765/ptsd-mental-illness-and-care-among-survivors-of-sexual-violence-in-northern-uganda-findings-from-the-ways-study
#13
Kennedy Amone-P'Olak, Ask Elklit, Sarah Bøgelund Dokkedahl
BACKGROUND: Previous studies have mainly considered war-affected youth as a homogenous group yet several subpopulations of war-affected youth, such as survivors of sexual violence, exist with unique mental health problems and treatment needs. This study aimed to assess posttraumatic stress disorder (PTSD), perceptions and meaning of mental illness, and access and barriers to mental health care among survivors of sexual violence. METHOD: Data were collected from survivors of sexual violence during war (N = 181) who are participants in the longitudinal War-Affected Youth Survey (WAYS) study in Northern Uganda...
July 31, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28703298/introduction-to-anatomy-on-wikipedia
#14
Thomas Stephen Ledger
Wikipedia (www.wikipedia.com) is the largest encyclopaedia in existence. Of over five million English-language articles, about 6000 relate to Anatomy, which are viewed roughly 30 million times monthly. No work parallels the amount of attention, scope or interdisciplinary layout of Wikipedia, and it offers a unique opportunity to improve the anatomical literacy of the masses. Anatomy on Wikipedia is introduced from an editor's perspective. Article contributors, content, layout and accuracy are discussed, with a view to demystifying editing for anatomy professionals...
July 12, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28694022/the-clinical-utility-of-repetitive-transcranial-magnetic-stimulation-in-reducing-the-risks-of-transitioning-from-acute-to-chronic-pain-in-traumatically-injured-patients
#15
REVIEW
Marianne Jodoin, Dominique Rouleau, Camille Larson-Dupuis, Nadia Gosselin, Louis De Beaumont
Pain is a multifaceted condition and a major ongoing challenge for healthcare professionals having to treat patients in whom pain put them at risk of developing other conditions. Significant efforts have been invested in both clinical and research settings in an attempt to demystify the mechanisms at stake and develop optimal treatments as well as to reduce individual and societal costs. It is now universally accepted that neuroinflammation and central sensitization are two key underlying factors causing pain chronification as they result from maladaptive central nervous system plasticity...
July 7, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28663164/assessing-user-engagement-of-an-mhealth-intervention-development-and-implementation-of-the-growing-healthy-app-engagement-index
#16
Sarah Taki, Sharyn Lymer, Catherine Georgina Russell, Karen Campbell, Rachel Laws, Kok-Leong Ong, Rosalind Elliott, Elizabeth Denney-Wilson
BACKGROUND: Childhood obesity is an ongoing problem in developed countries that needs targeted prevention in the youngest age groups. Children in socioeconomically disadvantaged families are most at risk. Mobile health (mHealth) interventions offer a potential route to target these families because of its relatively low cost and high reach. The Growing healthy program was developed to provide evidence-based information on infant feeding from birth to 9 months via app or website. Understanding user engagement with these media is vital to developing successful interventions...
June 29, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28648436/angiotensin-converting-enzyme-inhibitors-and-receptor-blockers-in-heart-failure-and-chronic-kidney-disease-demystifying-controversies
#17
REVIEW
Kader Muneer, Anishkumar Nair
In clinical setting, congestive heart failure (CHF) and chronic kidney disease (CKD) often co-exist in patients due to common underlying predisposing factors. An intricate equilibrium between the cardiovascular and renal system is maintained through rennin angiotensin-aldosterone axis and autonomic nervous system. Consequent to favorable hemodynamic modification, angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blocking (ARB) therapy have proven to be an indispensable aspect of heart failure management with morbidity and mortality benefit...
May 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28617233/demystifying-the-publication-process
#18
Jennifer Zelmer
No abstract text is available yet for this article.
May 2017: Healthcare Policy, Politiques de Santé
https://www.readbyqxmd.com/read/28607773/fto-gene-associates-and-interacts-with-obesity-risk-physical-activity-energy-intake-and-time-spent-sitting-pilot-study-in-a-nigerian-population
#19
Bolaji Fatai Oyeyemi, Charles Ayorinde Ologunde, Ayonposi Bukola Olaoye, Nanfizat Abiket Alamukii
Fat mass and obesity-associated (FTO) gene influences obesity but studies have shown that environmental/lifestyle variables like physical activity (PA), time spent sitting (TSS), and energy intake might mediate the effect. However, this is poorly understood in Nigeria due to scarce studies. We demystified association and interaction between FTO rs9939609, obesity, PA, TSS, and energy intake in Nigeria. FTO gene variant was genotyped by restriction fragment length polymorphism and gene sequencing analysis in 103 people with obesity and 98 controls...
2017: Journal of Obesity
https://www.readbyqxmd.com/read/28578328/gene-and-cell-doping-the-new-frontier-beyond-myth-or-reality
#20
Elmo W I Neuberger, Perikles Simon
The advent of gene transfer technologies in clinical studies aroused concerns that these technologies will be misused for performance-enhancing purposes in sports. However, during the last 2 decades, the field of gene therapy has taken a long and winding road with just a few gene therapeutic drugs demonstrating clinical benefits in humans. The current state of gene therapy is that viral vector-mediated gene transfer shows the now long-awaited initial success for safe, and in some cases efficient, gene transfer in clinical trials...
2017: Medicine and Sport Science
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