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https://www.readbyqxmd.com/read/27893808/common-polymorphisms-in-the-5-lipoxygenase-pathway-and-risk-of-incident-myocardial-infarction-a-danish-case-cohort-study
#1
Anders Gammelmark, Michael S Nielsen, Søren Lundbye-Christensen, Anne Tjønneland, Erik B Schmidt, Kim Overvad
BACKGROUND: The 5-lipoxygenase pathway (5-LOX) has been implicated in the development of cardiovascular disease and studies have suggested that genetic polymorphisms related to key enzymes in this pathway may confer risk of myocardial infarction (MI). This study investigated the association of pre-selected genetic polymorphisms in four candidate genes of 5-LOX (arachidonate 5-lipoxygenase and its activating protein (ALOX-5 and FLAP), leukotriene A4 hydroxylase (LTA4-H) and leukotriene C4 synthase (LTC4-S)) with incident MI...
2016: PloS One
https://www.readbyqxmd.com/read/27872268/consistent-functional-connectivity-alterations-in-schizophrenia-spectrum-disorder-a-multisite-study
#2
Kristina C Skåtun, Tobias Kaufmann, Nhat Trung Doan, Dag Alnæs, Aldo Córdova-Palomera, Erik G Jönsson, Helena Fatouros-Bergman, Lena Flyckt, Ingrid Melle, Ole A Andreassen, Ingrid Agartz, Lars T Westlye
Schizophrenia (SZ) is a severe mental illness with high heritability and complex etiology. Mounting evidence from neuroimaging has implicated disrupted brain network connectivity in the pathophysiology. However, previous findings are inconsistent, likely due to a combination of methodological and clinical variability and relatively small sample sizes. Few studies have used a data-driven approach for characterizing pathological interactions between regions in the whole brain and evaluated the generalizability across independent samples...
November 21, 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27775500/molecular-mapping-of-stem-rust-resistance-loci-effective-against-the-ug99-race-group-of-the-stem-rust-pathogen-and-validation-of-a-single-nucleotide-polymorphism-marker-linked-to-stem-rust-resistance-gene-sr28
#3
E M Babiker, T C Gordon, S Chao, M N Rouse, R Wanyera, M Acevedo, G Brown-Guedira, J M Bonman
Wheat landrace PI 177906 has seedling resistance to stem rust caused by Puccinia graminis f. sp. tritici races TTKSK, TTKST, and BCCBC and field resistance to the Ug99 race group. Parents, 140 recombinant inbred lines, and 138 double haploid (DH) lines were evaluated for seedling resistance to races TTKSK and BCCBC. Parents and the DH population were evaluated for field resistance to Ug99 in Kenya. The 90K wheat single nucleotide polymorphism (SNP) genotyping platform was used to genotype the parents and populations...
November 30, 2016: Phytopathology
https://www.readbyqxmd.com/read/27744491/qtl-mapping-identifies-a-major-locus-for-resistance-in-wheat-to-sunn-pest-eurygaster-integriceps-feeding-at-the-vegetative-growth-stage
#4
L C Emebiri, M-K Tan, M El-Bouhssini, O Wildman, A Jighly, W Tadesse, F C Ogbonnaya
This research provides the first report of a major locus controlling wheat resistance to Sunn pest. It developed and validated SNP markers that will be useful for marker-assisted selection. Sunn pest (Eurygaster integriceps Puton) is the most destructive insect pest of bread wheat and durum wheat in West and Central Asia and East Europe. Breeding for resistance at the vegetative stage of growth is vital in reducing the damage caused by overwintered adult populations that feed on shoot and leaves of seedlings, and in reducing the next generation of pest populations (nymphs and adults), which can cause damage to grain quality by feeding on spikes...
October 15, 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/27699767/glucuronic-acid-epimerase-glce-variant-rs3865014-a-g-is-associated-with-bmi-blood-hemoglobin-hypertension-and-cerebrovascular-events-the-tamrisk-study
#5
Tarja Kunnas, Tiina Solakivi, Kirsi Määttä, Seppo T Nikkari
Heparan sulfate proteoglycans modulate many physiological systems, and genes responsible for proteoglycan assembly and disassembly may affect their interaction. We sought to determine whether polymorphisms of the glucuronic acid epimerase (GLCE) rs3865014 and sulfatase-2 (SULF2) rs2281279, genes coding for enzymes participating in heparan sulfate side chain activity, associate with hypertension, selected cardiometabolic risk factors and cardiovascular events in the Tampere adult population cardiovascular risk study...
November 2016: Annals of Human Genetics
https://www.readbyqxmd.com/read/27676181/multiple-minor-qtls-are-responsible-for-fusarium-head-blight-resistance-in-chinese-wheat-landrace-haiyanzhong
#6
Jin Cai, Shan Wang, Tao Li, Guorong Zhang, Guihua Bai
Fusarium head blight (FHB), caused by Fusarium graminearum Schwabe, is a devastating disease in wheat (Triticum aestivum L.). Use of host resistance is one of the most effective strategies to minimize the disease damage. Haiyanzhong (HYZ) is a Chinese wheat landrace that shows a high level of resistance to FHB spread within a spike (type II resistance). To map the quantitative trait loci (QTLs) in HYZ and identify markers tightly linked to the QTLs for FHB resistance, a population of 172 recombinant inbred lines (RILs) from a cross between HYZ and Wheaton (FHB susceptible) was genotyped using simple sequence repeats (SSRs) and single-nucleotide polymorphisms (SNPs) derived from genotyping-by-sequencing (GBS), and evaluated for percentage of symptomatic spikelets (PSSs) per spike in three greenhouse experiments...
2016: PloS One
https://www.readbyqxmd.com/read/27669430/identification-of-genes-potentially-associated-with-the-fertility-instability-of-s-type-cytoplasmic-male-sterility-in-maize-via-bulked-segregant-rna-seq
#7
Aiguo Su, Wei Song, Jinfeng Xing, Yanxin Zhao, Ruyang Zhang, Chunhui Li, Minxiao Duan, Meijie Luo, Zi Shi, Jiuran Zhao
S-type cytoplasmic male sterility (CMS-S) is the largest group among the three major types of CMS in maize. CMS-S exhibits fertility instability as a partial fertility restoration in a specific nuclear genetic background, which impedes its commercial application in hybrid breeding programs. The fertility instability phenomenon of CMS-S is controlled by several minor quantitative trait locus (QTLs), but not the major nuclear fertility restorer (Rf3). However, the gene mapping of these minor QTLs and the molecular mechanism of the genetic modifications are still unclear...
2016: PloS One
https://www.readbyqxmd.com/read/27665367/the-eyespot-resistance-genes-pch1-and-pch2-of-wheat-are-not-homoeoloci
#8
M Pasquariello, J Ham, C Burt, J Jahier, S Paillard, C Uauy, P Nicholson
Phenotyping and mapping data reveal that chromosome intervals containing eyespot resistance genes Pch1 and Pch2 on 7D and 7A, respectively, do not overlap, and thus, these genes are not homoeloci. Eyespot is a stem-base fungal disease of cereals growing in temperate regions. Two main resistances are currently available for use in wheat. Pch1 is a potent single major gene transferred to wheat from Aegilops ventricosa and located on the distal end of chromosome 7D. Pch2, a moderate resistance deriving from Cappelle Desprez, is located at the end of 7AL...
September 24, 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/27607184/tryptophan-metabolism-along-the-kynurenine-pathway-downstream-of-toll-like-receptor-stimulation-in-peripheral-monocytes
#9
Funda Orhan, Maria Bhat, Kristian Sandberg, Sara Ståhl, Fredrik Piehl, Camilla Svensson, Sophie Erhardt, Lilly Schwieler
Tryptophan degradation along the kynurenine pathway is of central importance for the immune function. Toll-like receptors (TLRs), representing the first line of immune defense against pathogens, are expressed in various cell types. The most abundant expression is found on monocytes, macrophages and dendritic cells. The aim of the present study is to investigate if stimulation with different TLR ligands induces the kynurenine pathway in human peripheral monocytes. Cell supernatants were analyzed using a liquid chromatography/mass spectrometry to measure kynurenine, kynurenic acid (KYNA), quinolinic acid (QUIN) and tryptophan...
September 8, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27606429/single-nucleotide-polymorphism-discovery-in-bovine-pituitary-gland-using-rna-seq-technology
#10
Chandra Shekhar Pareek, Rafał Smoczyński, Haja N Kadarmideen, Piotr Dziuba, Paweł Błaszczyk, Marcin Sikora, Paulina Walendzik, Tomasz Grzybowski, Mariusz Pierzchała, Jarosław Horbańczuk, Agnieszka Szostak, Magdalena Ogluszka, Lech Zwierzchowski, Urszula Czarnik, Leyland Fraser, Przemysław Sobiech, Krzysztof Wąsowicz, Brian Gelfand, Yaping Feng, Dibyendu Kumar
Examination of bovine pituitary gland transcriptome by strand-specific RNA-seq allows detection of putative single nucleotide polymorphisms (SNPs) within potential candidate genes (CGs) or QTLs regions as well as to understand the genomics variations that contribute to economic trait. Here we report a breed-specific model to successfully perform the detection of SNPs in the pituitary gland of young growing bulls representing Polish Holstein-Friesian (HF), Polish Red, and Hereford breeds at three developmental ages viz...
2016: PloS One
https://www.readbyqxmd.com/read/27581540/fine-mapping-of-the-stem-rust-resistance-gene-srta10187
#11
Andrew T Wiersma, Linda K Brown, Elizabeth I Brisco, Tiffany L Liu, Kevin L Childs, Jesse A Poland, Sunish K Sehgal, Eric L Olson
SrTA10187 was fine-mapped to a 1.1 cM interval, candidate genes were identified in the region of interest, and molecular markers were developed for marker-assisted selection and Sr gene pyramiding. Stem rust (Puccinia graminis f. sp. tritici, Pgt) races belonging to the Ug99 (TTKSK) race group pose a serious threat to global wheat (Triticum aestivum L.) production. To improve Pgt host resistance, the Ug99-effective resistance gene SrTA10187 previously identified in Aegilops tauschii Coss. was introgressed into wheat, and mapped to the short arm of wheat chromosome 6D...
August 31, 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/27576474/snp-markers-in-allium-species-to-facilitate-introgression-breeding-in-onion
#12
Olga E Scholten, Martijn P W van Kaauwen, Arwa Shahin, Patrick M Hendrickx, L C Paul Keizer, Karin Burger, Adriaan W van Heusden, C Gerard van der Linden, Ben Vosman
BACKGROUND: Within onion, Allium cepa L., the availability of disease resistance is limited. The identification of sources of resistance in related species, such as Allium roylei and Allium fistulosum, was a first step towards the improvement of onion cultivars by breeding. SNP markers linked to resistance and polymorphic between these related species and onion cultivars are a valuable tool to efficiently introgress disease resistance genes. In this paper we describe the identification and validation of SNP markers valuable for onion breeding...
August 31, 2016: BMC Plant Biology
https://www.readbyqxmd.com/read/27544524/genetic-mapping-of-resistance-to-the-ug99-race-group-of-puccinia-graminis-f-sp-tritici-in-a-spring-wheat-landrace-citr-4311
#13
E M Babiker, T C Gordon, S Chao, M N Rouse, R Wanyera, M Newcomb, G Brown-Guedira, Z A Pretorius, J M Bonman
A gene for Ug99 resistance from wheat landrace CItr 4311 was detected on the long arm of chromosome 2B. Wheat landrace CItr 4311 has seedling resistance to stem rust caused by Puccinia graminis f. sp. tritici race TTKSK and field resistance to the Ug99 race group. Parents, F1 seedlings, 121 doubled haploid (DH) lines, and 124 recombinant inbred lines (RILs) developed from a cross between CItr 4311 and the susceptible line LMPG-6 were evaluated for seedling resistance to race TTKSK. Goodness-of-fit tests indicated that a single dominant gene in CItr 4311 conditioned the TTKSK resistance...
August 20, 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/27512836/clinical-features-of-hispanic-thyroid-cancer-cases-and-the-role-of-known-genetic-variants-on-disease-risk
#14
Ana P Estrada-Florez, Mabel E Bohórquez, Ruta Sahasrabudhe, Rodrigo Prieto, Paul Lott, Carlos S Duque, Jorge Donado, Gilbert Mateus, Fernando Bolaños, Alejandro Vélez, Magdalena Echeverry, Luis G Carvajal-Carmona
Thyroid cancer (TC) is the second most common cancer among Hispanic women. Recent genome-wide association (GWA) and candidate studies identified 6 single nucleotide polymorphisms (SNPs; rs966423, rs2439302, rs965513, rs6983267, rs944289, and rs116909374), associated with increased TC risk in Europeans but their effects on disease risk have not been comprehensively tested in Hispanics. In this study, we aimed to describe the main clinicopathological manifestations and to evaluate the effects of known SNPs on TC risk and on clinicopathological manifestations in a Hispanic population...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27487851/human-fetuin-a-rs4918-polymorphism-and-its-association-with-obesity-in-healthy-persons-and-in-patients-with-myocardial-infarction-in-two-hungarian-cohorts
#15
György Temesszentandrási, Krisztián Vörös, Bernadett Márkus, Zoltán Böröcz, Edit Kaszás, Zoltán Prohászka, András Falus, Károly Cseh, László Kalabay
BACKGROUND Human fetuin A (AHSG) has been associated with the development of obesity, insulin resistance, type 2 diabetes mellitus, and atherosclerosis. Observations on the role of AHSG rs4918 single-nucleotide polymorphism are contradictory. We investigated the association between variants of rs4918 and parameters of obesity, lipid status, tumor necrosis factor-α (TNFα), adipokines (adiponectin, resistin, leptin), and insulin resistance in healthy persons and in patients with previous myocardial infarction...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27486464/genome-wide-qtl-mapping-for-wheat-processing-quality-parameters-in-a-gaocheng-8901-zhoumai-16-recombinant-inbred-line-population
#16
Hui Jin, Weie Wen, Jindong Liu, Shengnan Zhai, Yan Zhang, Jun Yan, Zhiyong Liu, Xianchun Xia, Zhonghu He
Dough rheological and starch pasting properties play an important role in determining processing quality in bread wheat (Triticum aestivum L.). In the present study, a recombinant inbred line (RIL) population derived from a Gaocheng 8901/Zhoumai 16 cross grown in three environments was used to identify quantitative trait loci (QTLs) for dough rheological and starch pasting properties evaluated by Mixograph, Rapid Visco-Analyzer (RVA), and Mixolab parameters using the wheat 90 and 660 K single nucleotide polymorphism (SNP) chip assays...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27359266/markers-linked-to-wheat-stem-rust-resistance-gene-sr11-effective-to-puccinia-graminis-f-sp-tritici-race-tkttf
#17
Jayaveeramuthu Nirmala, Shiaoman Chao, Pablo Olivera, Ebrahiem M Babiker, Bekele Abeyo, Zerihun Tadesse, Muhammad Imtiaz, Luther Talbert, Nancy K Blake, Eduard Akhunov, Michael O Pumphrey, Yue Jin, Matthew N Rouse
Wheat stem rust, caused by Puccinia graminis f. sp. tritici, can cause severe yield losses on susceptible wheat varieties and cultivars. Although stem rust can be controlled by the use of genetic resistance, population dynamics of P. graminis f. sp. tritici can frequently lead to defeat of wheat stem rust resistance genes. P. graminis f. sp. tritici race TKTTF caused a severe epidemic in Ethiopia on Ug99-resistant 'Digalu' in 2013 and 2014. The gene Sr11 confers resistance to race TKTTF and is present in 'Gabo 56'...
November 2016: Phytopathology
https://www.readbyqxmd.com/read/27315044/decorin-genotypes-serum-glucose-heart-rate-and-cerebrovascular-events-the-tampere-adult-population-cardiovascular-risk-study
#18
Tarja Kunnas, Tiina Solakivi, Kirsi Määttä, Seppo T Nikkari
BACKGROUND: Decorin is an extracellular matrix proteoglycan that may attenuate progression of atherosclerosis and its complications, such as stroke. Among its multitude of functions, decorin has been suggested to serve as a receptor for resistin, an adipokine involved in energy homeostasis. The GG genotype of the decorin polymorphism rs7308752 (A>G) and the CC genotype of the rs516115 (T>C) are associated with decreased plasma resistin levels. AIMS: The association of the above decorin genotypes with selected cardiometabolic risk factors and cerebrovascular events was studied in the Tampere adult population cardiovascular risk (TAMRISK) study...
August 2016: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/27306516/development-and-validation-of-kasp-assays-for-genes-underpinning-key-economic-traits-in-bread-wheat
#19
Awais Rasheed, Weie Wen, Fengmei Gao, Shengnan Zhai, Hui Jin, Jindong Liu, Qi Guo, Yingjun Zhang, Susanne Dreisigacker, Xianchun Xia, Zhonghu He
We developed and validated a robust marker toolkit for high-throughput and cost-effective screening of a large number of functional genes in wheat. Functional markers (FMs) are the most valuable markers for crop breeding programs, and high-throughput genotyping for FMs could provide an excellent opportunity to effectively practice marker-assisted selection while breeding cultivars. Here we developed and validated kompetitive allele-specific PCR (KASP) assays for genes that underpin economically important traits in bread wheat including adaptability, grain yield, quality, and biotic and abiotic stress resistances...
October 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/27270476/genetic-variations-in-fsh-action-affect-sex-hormone-levels-and-breast-tissue-size-in-infant-girls-a-pilot-study
#20
Louise Scheutz Henriksen, Casper P Hagen, Maria Assens, Alexander S Busch, Niels E Skakkebæk, Kristian Almstrup, Katharina M Main
CONTEXT: Single nucleotide polymorphisms altering FSH action (FSHB -211G>T, FSHR -29G>A, and FSHR 2039A>G) are associated with peripubertal and adult levels of reproductive hormones and age at pubertal onset in girls. OBJECTIVE: To investigate whether genetic polymorphisms altering FSH action affect serum levels of female reproductive hormones and breast development as early as during minipuberty. DESIGN: Longitudinal study. SETTING: Population-based cohort study...
August 2016: Journal of Clinical Endocrinology and Metabolism
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