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high fibrinogen

Ahmed A Farghaly, Rezaul K Khan, Maryanne M Collinson
A new electrosynthetic approach for the fabrication of three-dimensional bicontinuous nanoporous platinum-based (3D-BC-NP-Pt(Au)) electrodes is described. Binary Pt-Ag alloys are first electrodeposited on gold substrates from appropriately formulated plating solutions. Following annealing and dealloying, a new family of nanoporous platinum-based electrodes emerges whose morphology, porosity, and chemical compositions depend on electrodeposition parameters and plating solution composition. Scanning electron microscopy images reveal an interesting and distinctive nanoporous gold-like microstructure with pores and ligaments in the 10-30 nm range arranged in a bicontinuous fashion throughout the thickness of the film...
June 15, 2018: ACS Applied Materials & Interfaces
S Sun, P Chen, L Meng, L Li, Z Mo, C Sun, Y Wang, F Liang
This study was performed to investigate the prognostic significance of a cumulative score based on the preoperative plasma fibrinogen and serum albumin (FA score) in operable esophageal squamous cell carcinoma (ESCC). Clinicopathologic characteristics, preoperative fibrinogen, and albumin concentrations were retrospectively reviewed in patients who underwent transthoracic esophagectomy. The optimal cutoff value was defined as 4.0 g/L for fibrinogen according to previous studies and as 41.0 g/L for albumin for the lower quartile...
June 14, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Leslie C Sharkey, Kim J Little, Kevin D Williams, Jeffrey M Todd, Rae Richardson, Angela D Gwynn, Aaron Rendahl
OBJECTIVE: To evaluate the technical performance of the turbidimetric ACL-TOP CTS 300 coagulation analyzer (IL) in dogs and cats and to create reference intervals for standard and novel parameters. DESIGN: Coagulation testing results from dogs and cats generated by the IL were prospectively compared with another mechanical clot detection system. Precision was documented and reference intervals were created for prothrombin time, activated partial thromboplastin time, and Clauss fibrinogen and D-dimer values, as well as for the quantitative clot curve parameters (high and low amplitude, delta, and first and second derivative curves)...
June 14, 2018: Journal of Veterinary Emergency and Critical Care
Apostolos Davillas, Andrew M Jones
Recent advances in social science surveys include collection of biological samples. Although biomarkers offer a large potential for social science and economic research, they impose a number of statistical challenges, often being distributed asymmetrically with heavy tails. Using data from the UK Household Panel Survey, we illustrate the comparative performance of a set of flexible parametric distributions, which allow for a wide range of skewness and kurtosis: the four-parameter generalized beta of the second kind (GB2), the three-parameter generalized gamma, and their three-, two-, or one-parameter nested and limiting cases...
June 14, 2018: Health Economics
Setor K Kunutsor, Tanjaniina Laukkanen, Jari A Laukkanen
PURPOSE: We sought to determine cross-sectional and longitudinal associations of frequency of sauna bathing with high sensitivity C-reactive protein (hsCRP), fibrinogen, leucocyte count, and gamma-glutamyltransferase (GGT). DESIGN: Baseline sauna bathing habits were assessed in 2269 men aged 42-61 years. Concentrations of hsCRP, fibrinogen, leucocyte count, and GGT were determined at baseline and 11 years later. The associations of sauna bathing frequency with baseline and 11-year hsCRP, fibrinogen, leucocyte count, and GGT levels were examined using robust multivariate regression analyses...
June 13, 2018: Annals of Medicine
Daniel H Moreno, Daniel G Cacione, Jose Cc Baptista-Silva
BACKGROUND: An abdominal aortic aneurysm (AAA) is the pathological enlargement of the aorta and can develop in both men and women. Progressive aneurysm enlargement can lead to rupture. The rupture of an AAA is frequently fatal and accounts for the death from haemorrhagic shock of at least 45 people per 100,000 population. The outcome of people with ruptured AAA varies among countries and healthcare systems, with mortality ranging from 53% to 90%. Definitive treatment for ruptured AAA includes open surgery or endovascular repair...
June 13, 2018: Cochrane Database of Systematic Reviews
S M Klim, F Amerstorfer, G Gruber, G A Bernhardt, R Radl, L Leitner, A Leithner, M Glehr
The early and accurate diagnosis of periprosthetic joint infection (PJI) can be challenging. Fibrinogen plays an important role in mediating inflammation of bacterial infections and therefore could be a valuable biomarker for PJI. The purpose of this study was to investigate the sensitivity and specificity of serum levels of fibrinogen in detecting PJI, and to compare the results with the established PJI biomarkers C-reactive protein (CRP) and leukocyte count. Eighty-four patients (124 surgeries) were prospectively included...
June 11, 2018: Scientific Reports
V Montalván Ayala, Z Rojas Cheje, R Aldave Salazar
INTRODUCTION: The use of low doses of recombinant tissue plasminogen activator (rt-PA) was initially proposed in Asian countries in response to racial peculiarities related to the functionality of fibrinogen and coagulation factors that potentially increased the risk of intracerebral haemorrhage, and with a view to saving costs. In view of the controversy over the use of rt-PA below the standard dose, we conducted a literature review of studies promoting the use of low doses or comparing different doses of rt-PA...
June 8, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
J A Barea-Mendoza, L J Terceros-Almanza, C García-Fuentes, S Bermejo-Aznárez, I J Prieto Del Portillo, C Mudarra-Reche, M Valiente-Fernández, A Rodríguez-Biendicho, J C Montejo González, M Chico-Fernández
BACKGROUND: Hypoperfusion plays a central role in shock states, and has been proposed as a coagulopathy trigger. The study of the rotational thromboelastometry (ROTEM) profile during cardiac arrest could offer new insights to the role of hypoperfusion in coagulation during shock states. OUTCOME: To describe the ROTEM profile in a cohort of asystole donors and elucidate the incidence of hyperfibrinolysis. DESIGN: A prospective observational study was carried out in 18 patients consecutively admitted to the ICU after out-of-hospital non-recovered cardiac arrest (CA)...
June 7, 2018: Medicina Intensiva
Dacia D C A Henriquez, Kitty W M Bloemenkamp, Johanna G van der Bom
Postpartum hemorrhage is the leading cause of maternal mortality and severe morbidity. Despite efforts to improve maternal outcomes, management of postpartum hemorrhage still faces at least four challenges, discussed in this review. First, current definitions for severe postpartum hemorrhage hamper early identification of women with high risk of adverse outcome. Adaptations to the definitions and the use of clinical tools such as shock index and early warning systems may facilitate this early identification...
June 8, 2018: Journal of Thrombosis and Haemostasis: JTH
Mariam Amouzandeh, Greg Nowak, Anna Januszkiewicz, Jan Wernerman, Olav Rooyackers, Åke Norberg
BACKGROUND: In major abdominal surgery albumin is shifted from the circulation, presumably leaking into the interstitial space, contributing to a 30-40% decrease in plasma albumin concentration. During and after liver transplantation exogenous albumin is infused for volume substitution and to maintain plasma albumin concentration. Here we used liver transplantation as a model procedure for the study of albumin mass balance and kinetics during major abdominal surgery with albumin substitution...
June 7, 2018: Critical Care: the Official Journal of the Critical Care Forum
Chen-Jung Lee, Huifang Wang, Megan Young, Shengxi Li, Fang Cheng, Hongbo Cong, Gang Cheng
Poly(3,4-ethylenedioxythiophene) (PEDOT) has been widely studied in recent decades due to its high stability, biocompatibility, low redox potential, moderate band gap, and optical transparency in its conducting state. However, for its long-term in vivo applications, the biocompatibility of PEDOT still need to be improved. To address this challenge, zwitterionic Poly(sulfobetaine 3,4-ethylenedioxythiophene) (PSBEDOT) that contains EDOT backbone with sulfobetaine functional side chains were developed in our previous study...
June 4, 2018: Acta Biomaterialia
Rui Ji, Qian Ren, Suyang Bai, Yuping Wang, Yongning Zhou
High pretreatment levels of plasma fibrinogen have been widely reported to be a potential predictor of prognosis in digestive system tumors; however, the conclusions are not consistent. Therefore, we performed a meta-analysis to comprehensively assess the prognostic roles of high pretreatment plasma fibrinogen levels in digestive system tumors. We searched for eligible studies in the PubMed, Embase, and Web of Science electronic databases for publications from the database inception to 1 September 2017. The endpoints of interest included overall survival, disease-free survival, and recurrence-free survival...
June 1, 2018: International Journal of Biological Markers
Meiling Luo, Aiqiu Wei, Liqun Xiang, Jie Yan, Lin Liao, Xuelian Deng, Donghong Deng, Peng Cheng, Faquan Lin
We found a heterozygous dysfibrinogenemia caused by a substitution of AαArg16Cys. The proband suffered multiple cerebral infarctions. Routine coagulation tests revealed a prolonged thrombin time. The fibrinogen levels in the functional assays were considerably lower than the levels in the immunological assays. The polymerization of the purified fibrinogen was strongly impaired in the presence of calcium. As previously observed in other heterozygous Aα R16C variants, the release rate and amount of fibrinopeptide A (FPA) were lower in the proband than those in normal controls...
June 5, 2018: Journal of Thrombosis and Thrombolysis
Jing-Yi Li, Junsong Gong, Fang Zhu, Jessica Moodie, Amy Newitt, Lavanya Uruthiramoorthy, Davy Cheng, Janet Martin
BACKGROUND: Postoperative bleeding remains a frequent complication after cardiovascular surgery and may contribute to serious morbidity and mortality. Observational studies have suggested a relationship between low endogenous plasma fibrinogen concentration and increased risk of postoperative blood loss in cardiac surgery. Although the transfusion of fibrinogen concentrate has been increasing, potential benefits and risks associated with perioperative fibrinogen supplementation in cardiovascular surgery are not fully understood...
May 31, 2018: Anesthesia and Analgesia
Bo Tian, Chunfeng Song, Hui Li, Wenqian Zhang, Qirui Chen, Shuo Chen, Yili Fu, Xiaoxing Hu, Bin You, Tong Li, Bin Hu, Shengcai Hou
Background: The high incidence of venous thromboembolism (VTE) has been perceived in post thoracic surgery patients. However, the significance of perioperative coagulation and fibrinolysis related parameters after lung surgery for VTE predicting is not clear. To investigate that, we conducted a prospective single center study. Methods: A total of 111 patients undergoing lung surgery were enrolled in this study, included 52 primary lung cancer patients and 59 benign lung disease patients from July 2016 to March 2017...
April 2018: Journal of Thoracic Disease
Mingting Deng, Lin Tang, Dongmei Huang, Zhongjie Wang, Junli Chen
OBJECTIVES: To determine and compare the prevalence of vitamin D deficiency in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD). METHODS: The level of vitamin D was determined by the serum levels of 1,25(OH)2D3. We evaluated 144 patients in our study, including 53 subjects in the CTD-ILD group and 91 subjects in the CTD group without ILD. CTD was diagnosed following the American College of Rheumatology criteria, and ILD was diagnosed by high-resolution computed tomography...
May 24, 2018: Clinical and Experimental Rheumatology
Yang Zhang, Hui-Xia Qiao, Yong-Tao Zhou, Liang Hong, Ju-Hui Chen
The protective role of fibrinogen‑like‑protein 1 (FGL1) in liver injury has been reported previously. However, there are few studies on FGL1 expression in gastric cancer (GC) tissues, and the role of FGL1 in GC remains unclear. The aim of the present study was to investigate the correlation between FGL1 expression and prognosis in GC patients. Data was downloaded from The Cancer Genome Atlas database, and 50 pairs of GC tissues and the corresponding non‑tumor tissues were collected between 2008 to 2011...
May 29, 2018: Molecular Medicine Reports
En Yu, Hsin-Yin Hsu, Chun-Yuan Huang, Lee-Ching Hwang
Background: Non-alcoholic fatty liver disease is an increasing health issue that associates with the development of atherosclerotic cardiovascular disease. This study correlates the association between fatty liver and inflammatory biomarkers with cardiovascular risk scores. Methodology: This cross-sectional study enrolled 10,181 health examination participants from Northern Taiwan and administered a standardized questionnaire with important biochemical tests and abdominal sonography...
2018: Open Medicine (Warsaw, Poland)
Pei-Xin Lai, Ju-Yi Mao, Binesh Unnikrishnan, Han-Wei Chu, Chien-Wei Wu, Huan-Tsung Chang, Chih-Ching Huang
Graphene oxide (GO) has unique structural properties, can effectively adsorb single-strand DNA through π-π stacking, hydrogen bonding and hydrophobic interactions, and is useful in many biotechnology applications. In this study, we developed a thrombin-binding-aptamers (15- and 29-mer) conjugated graphene oxide (TBA15/TBA29-GO) composite for the efficient inhibition of thrombin activity towards the formation of fibrin from fibrinogen. The TBA15/TBA29-GO composite was simply obtained by the self-assembly of TBA15/TBA29 hybrids on GO...
May 29, 2018: Biomaterials Science
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