keyword
https://read.qxmd.com/read/38425280/successful-treatment-of-severe-passenger-lymphocyte-syndrome-with-efgartigimod-synergy
#1
R Christopher Chase, Andree H Koop, Marwan Shaikh, Robin J Imperial, Denise M Harnois, Nicole M Loo, Jennifer J O'Brien
INTRODUCTION: This case describes passenger lymphocyte syndrome (PLS) generating human platelet antigen 1a (HPA-1a) alloantibodies against the recipient's platelets after liver transplant. Given the rarity of PLS, especially in liver transplant with HPA-1a alloantibodies, disease course and management options are poorly described. METHODS: The patient had cirrhosis secondary to nonalcoholic steatohepatitis complicated by hepatocellular carcinoma, encephalopathy, and severe ascites...
March 1, 2024: Transfusion
https://read.qxmd.com/read/38350984/myelin-oligodendrocyte-glycoprotein-mog-associated-optic-neuritis-in-a-patient-with-idiopathic-intracranial-hypertension-iih-and-compressive-optic-neuropathy-case-report
#2
JOURNAL ARTICLE
Ryan D Sorensen, Ashtyn Vogt, Noor Laylani, Mohammad Pakravan, Andrew G Lee
BACKGROUND: Myelin oligodendrocyte glycoprotein-associated disease (MOGAD) has a wide phenotypic expression and should be considered in a differential diagnosis of patients with optic disc edema and increased intracranial pressure because MOGAD can mimic IIH and compressive optic neuropathy. CASE PRESENTATION: A 53-year-old woman with a history of presumed idiopathic intracranial hypertension ("IIH") presented with new headache and visual loss. She had a BMI of 35...
February 13, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38231723/a-rare-case-of-nephrotic-syndrome-in-the-setting-of-sjogren-syndrome-related-cryoglobulinemic-vasculitis
#3
JOURNAL ARTICLE
Zoi Alexakou, Katerina Damianaki, Emelina Stambolliu, Dimitrios Kourniotis, Margarita Mpora, Dimitrios Petras
Cryoglobulinemia is a rare entity which frequently occurs in the setting of an underlying disease, with chronic hepatitis C virus infections and primary Sjogren syndrome being the most common underlying conditions. Cryoglobulinemic vasculitis (CV) is an immune-mediated type of small-vessel vasculitis with a broad spectrum of specific organ involvement, including renal, pulmonary, peripheral nerve, and cutaneous involvement and variable manifestations that can be life threatening. Moreover, a strong relationship between cryoglobulinemia and CV, with the future development of lymphoma, is well established...
May 1, 2023: Saudi Journal of Kidney Diseases and Transplantation
https://read.qxmd.com/read/38195767/exosomal-micrornas-as-biomarkers-for-viral-replication-in-tofacitinib-treated-rheumatoid-arthritis-patients-with-hepatitis-c
#4
JOURNAL ARTICLE
Tsai-Ling Liao, I-Chieh Chen, Hong-Wei Chen, Kuo-Tung Tang, Wen-Nan Huang, Yi-Hsing Chen, Yi-Ming Chen
Notwithstanding recent advances in direct antiviral specialists (DAAs) for hepatitis C infection (HCV), it is yet a pervasive overall issue in patients with rheumatoid arthritis (RA). Exosomal microRNAs (miRNAs) is associated with HCV infection. However, it remains unknown how miRNAs respond following biologic disease-modifying antirheumatic drug (bDMARD) and targeted synthetic DMARD (tsDMARD) treatment in HCV patients with RA. We prospectively recruited RA patients taking anti-tumor necrosis factor-α (TNF-α) inhibitors rituximab (RTX) and tofacitinib...
January 10, 2024: Scientific Reports
https://read.qxmd.com/read/38046251/epidemiological-characteristics-of-hepatitis-b-and-c-in-patients-with-inflammatory-arthritis-implications-from-treasure-database
#5
JOURNAL ARTICLE
Emine Duygu Ersözlü, Mustafa Ekici, Belkis Nihan Coşkun, Suade Özlem Badak, Emre Bilgin, Umut Kalyoncu, Burcu Yağız, Yavuz Pehlivan, Orhan Küçükşahin, Abdulsamet Erden, Dilek Solmaz, Pamir Atagündüz, Gezmiş Kimyon, Cemal Beş, Seda Çolak, Rıdvan Mercan, Timuçin Kaşifoğlu, Hakan Emmungil, Nilüfer Alpay Kanıtez, Aşkın Ateş, Süleyman Serdar Koca, Sedat Kiraz, İhsan Ertenli
OBJECTIVES: This study aimed to evaluate the hepatitis B (HBV) and C (HCV) frequency and clinical characteristics among patients with rheumatoid arthritis (RA) or spondyloarthritis (SpA) who receive biological treatments. PATIENTS AND METHODS: The observational study was conducted with patients from the TReasure database, a web-based prospective observational registry collecting data from 17 centers across Türkiye, between December 2017 and June 2021. From this database, 3,147 RA patients (2,502 males, 645 females; median age 56 years; range, 44 to 64 years) and 6,071 SpA patients (2,709 males, 3,362 females; median age 43 years; range, 36 to 52 years) were analyzed in terms of viral hepatitis, patient characteristics, and treatments used...
September 2023: Archives of Rheumatology
https://read.qxmd.com/read/37959271/therapeutic-potential-of-rituximab-in-managing-hepatitis-c-associated-cryoglobulinemic-vasculitis-a-systematic-review
#6
REVIEW
Andreea Covic, Irina Draga Caruntu, Alexandru Burlacu, Simona Eliza Giusca, Adrian Covic, Anca Elena Stefan, Crischentian Brinza, Gener Ismail
(1) Background. Hepatitis C infection often leads to extrahepatic manifestations, including cryoglobulinemic vasculitis. This systematic review aimed to assess the efficacy and safety of rituximab in treating hepatitis C-associated cryoglobulinemic vasculitis. (2) Methods. Following PRISMA guidelines, databases were searched for relevant studies. Eligibility criteria included studies on hepatitis C-associated cryoglobulinemic vasculitis treated with rituximab. (3) Results. Nine studies met the eligibility criteria and were included in this analysis...
October 27, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37916482/cryoglobulinemic-vasculitis-a-2023-update
#7
REVIEW
Michele Moretti, Francesco Ferro, Chiara Baldini, Marta Mosca, Rosaria Talarico
PURPOSE OF REVIEW: Cryoglobulinemic vasculitis (CV) is an immune complex mediated small vessel vasculitis characterized by the presence of cryoglobulins in serum, often associated with hepatitis C infection, systemic autoimmune diseases or hematological conditions. The focus of this review is to provide an update on new insights into pathogenesis, epidemiology and therapies of infectious and noninfectious type II and type III CV. RECENT FINDINGS: The introduction of new antiviral drugs for treatment of hepatitis C infection implied major changes in HCV-related CV, allowing to shed new lights on CV pathogenesis and mechanisms of relapse and, therefore, to increase the relevance of autoimmune diseases in CV epidemiology...
January 1, 2024: Current Opinion in Rheumatology
https://read.qxmd.com/read/37728653/-diagnosis-and-treatment-of-glomerular-diseases-with-a-membranoproliferative-glomerulonephritis-mpgn-pattern-of-injury
#8
JOURNAL ARTICLE
Michael Rudnicki, Martin Windpessl, Kathrin Eller, Balazs Odler, Philipp Gauckler, Irmgard Neumann, Emanuel Zitt, Heinz Regele, Andreas Kronbichler, Karl Lhotta, Marcus D Säemann
Membranoproliferative glomerulonephritis (MPGN) represents a heterogeneous group of diseases. The common feature of a membranoproliferative lesion pattern in the kidney biopsy can either be idiopathic/primary or-much more frequently-have a secondary cause. The historical classification into MPGN types I to III has largely been abandoned and replaced in recent years by a pathogenesis-oriented classification. A MPGN with C1q, C3 and/or C4 deposits on light microscopy is referred to as immune complex GN (IC-GN), while a MPGN with dominant C3 deposits is referred to as C3 glomerulopathy (C3G)...
August 2023: Wiener Klinische Wochenschrift
https://read.qxmd.com/read/37621746/type-b-lactic-acidosis-in-a-patient-with-mantle-cell-lymphoma
#9
Ikemsinachi C Nzenwa, Margaret Berquist, Toby J Brenner, Aida Ansari, Hamid D Al-Fadhl, Michael Aboukhaled, Shivani S Patel, Ethan E Peck, Mahmoud D Al-Fadhl, Anthony V Thomas, Nuha Zackariya, Mark M Walsh, Jose A Bufill
Type B lactic acidosis is an uncommon medical emergency in which acid production overwhelms hepatic clearance. This specific etiology of lactic acidosis occurs without organ hypoperfusion and has been most commonly described in patients with hematologic malignancies but also in patients with solid tumors. The mechanism by which cancer cells switch their glucose metabolism toward increasingly anaerobic glycolytic phenotypes has been described as the "Warburg effect." Without treating the underlying malignancy, the prognosis for patients diagnosed with malignancy-related type B lactic acidosis is extremely poor...
2023: Case Reports in Critical Care
https://read.qxmd.com/read/37543174/malignant-lymphoma-after-liver-transplantation-for-liver-cirrhosis-caused-by-human-immunodeficiency-virus-and-hepatitis-c-virus-co-infection
#10
Yasushi Hasegawa, Hideaki Obara, Taku Kikuchi, Shunsuke Uno, Hanako Tsujikawa, Yohei Yamada, Shutaro Hori, Susumu Eguchi, Yuko Kitagawa
Here, we describe a rare case of malignant lymphoma after liver transplantation for liver cirrhosis caused by human immunodeficiency virus (HIV) and hepatitis C virus (HCV) co-infection. A male patient was diagnosed with hemophilia A at 8 months of age. Since then, he had been receiving blood products, which led to HIV and HCV co-infection. His HIV viral load was suppressed with antiretroviral therapy, and a sustained virologic response was achieved for HCV using direct-acting antivirals. However, his decompensated liver cirrhosis progressed, and deceased donor liver transplantation was performed...
August 3, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37481391/early-postoperative-varicella-zoster-virus-encephalitis-after-adult-abo-incompatible-living-donor-liver-transplantation-a-case-report
#11
JOURNAL ARTICLE
Katsunori Sakamoto, Kohei Ogawa, Kei Tamura, Masahiko Honjo, Kyosei Sogabe, Chihiro Ito, Miku Iwata, Akimasa Sakamoto, Yusuke Nishi, Mio Uraoka, Tomoyuki Nagaoka, Naotake Funamizu, Yasutsugu Takada
There have never been any reports of adult varicella-zoster virus (VZV) encephalitis cases. Here, we report a case of VZV encephalitis after adult ABO-incompatible living donor liver transplantation (LDLT). A 38-year-old man with decompensated liver cirrhosis caused by the hepatitis C virus was referred to our hospital as an LDLT candidate. Rituximab was administered 3 weeks before the operation, and immunosuppression agents were administered 1 week before the LDLT. Plasma exchange was performed 3 times before the LDLT...
July 20, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37448907/a-case-of-posttransplant-fibrillary-glomerulonephritis
#12
Shiva Kumar Ammayappan, Arul Rajagopalan, Manorajan Rajendran, Jegan Arunachalam, Arun Prasath, Rakesh Durai, Anila A Kurien
Fibrillary glomerulonephritis (FGN) is a rare form of glomerulonephritis, usually occurring in concurrence with other conditions such as hepatitis C, dysproteinemia, autoimmune conditions, diabetes mellitus, and malignancy. The diagnosis is made by the presence of randomly oriented fibrillar deposits with a mean diameter of 20 nm, which stain positive for IgG and C3 and are negative for congo red and thioflavin T stains. Staining for DNAJB9 (DnaJ homolog subfamily B member 9) is a recently discovered mode of diagnosis of FGN without electron microscopy...
2023: Indian Journal of Nephrology
https://read.qxmd.com/read/37394661/type-ii-cryoglobulinemic-membranoproliferative-glomerulonephritis-caused-by-mucosa-associated-lymphoid-tissue-lymphoma
#13
JOURNAL ARTICLE
Ayano Sugihara, Hiroshi Ureshino, Masatora Yamasaki, Makoto Fukuda, Maki Yoshihara, Eriko Nonaka, Mariko Miyazaki, Mai Fujita, Keitaro Ishii, Kazuharu Kamachi, Haruhiko Sano, Sho Okamoto, Hidekazu Itamura, Mariko Yoshimura, Hiroo Katsuya, Toshihiko Ando, Shigehisa Aoki, Yoshifumi Ubara, Shinya Kimura
A 67-year-old man complained of lower limb edema with a purpuric skin rash. Laboratory tests revealed proteinuria, elevated serum creatinine levels, and low serum albumin levels. The patient was also positive for cryoglobulin in serum, immunoglobulin (Ig) M gammopathy, hypocomplementemia, and rheumatoid factor. He was negative for anti-hepatitis C virus antibodies. A pathological analysis of the renal tissue revealed membranoproliferative glomerulonephritis, common histological features of cryoglobulinemic vasculitis (CV), and mucosa-associated lymphoid tissue lymphoma invasion...
2023: Internal Medicine
https://read.qxmd.com/read/36961143/metastatic-pancreatic-ductal-adenocarcinoma-followed-by-a-fatal-diffuse-large-b-cell-lymphoma-a-rare-case-report-and-literature-review
#14
REVIEW
Atsushi Yamaguchi, Naohiro Kato, Shuhei Sugata, Takuro Hamada, Nao Furuya, Takeshi Mizumoto, Yuzuru Tamaru, Ryusaku Kusunoki, Toshio Kuwai, Hirotaka Kouno, Miki Kido, Takuo Ito, Kazuya Kuraoka, Hiroshi Kohno
RATIONALE: Recently, the incidence of polyoncosis has been increasing due to advancements in treatment, such as antitumor therapy, which led to a prolonged survival. However, few patients with metastatic pancreatic ductal adenocarcinoma (PDAC) develop second tumors, which render a poor prognosis. We report a rare case of PDAC, which is metachronous with a fatal malignant lymphoma (ML). PATIENT CONCERNS: A 68-year-old woman who had been monitored due to liver cirrhosis secondary to hepatitis C virus infection presented with a 10-mm pancreatic head cancer with lung metastasis and had started an anticancer therapy with gemcitabine...
March 24, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/36949515/sequential-central-retinal-artery-occlusions-associated-with-cryoglobulinemia
#15
JOURNAL ARTICLE
Patrick Wang, Pushpinder Kanda, Yao Wang, Manpartap Bal
BACKGROUND: Cryoglobulinemia, the presence of serum cryoglobulins which are immunoglobulins or complement components that precipitate at temperatures below 37 °C, commonly present with cutaneous manifestations initially, but are more rarely associated with ocular manifestations. To our knowledge, we report the first case of a patient presenting with sequential central retinal artery occlusion (CRAO) associated with cryoglobulinemia. CASE PRESENTATION: A 69-year-old female with a history of indolent B-cell lymphoma associated cryoglobulinemia, treated hepatitis B infection and CRAO in the left eye presented with acute vision loss and diffuse retinal whitening with a cherry red spot in her right eye, suggestive of sequential CRAO...
March 22, 2023: International Journal of Retina and Vitreous
https://read.qxmd.com/read/36733229/biological-features-and-outcome-of-diffuse-large-b-cell-lymphoma-associated-with-hepatitis-c-virus-in-elderly-patients-results-of-the-prospective-elderly-project-by-the-fondazione-italiana-linfomi
#16
JOURNAL ARTICLE
Annalisa Arcari, Valentina Tabanelli, Francesco Merli, Luigi Marcheselli, Michele Merli, Monica Balzarotti, Vittorio Ruggero Zilioli, Alberto Fabbri, Federica Cavallo, Gloria Margiotta Casaluci, Alessandra Tucci, Benedetta Puccini, Elsa Pennese, Alice Di Rocco, Manuela Zanni, Leonardo Flenghi, Guido Gini, Roberto Sartori, Annalisa Chiappella, Sara Veronica Usai, Monica Tani, Dario Marino, Luca Arcaini, Daniele Vallisa, Michele Spina
Up to 10%-15% of diffuse large B-cell lymphoma (DLBCL) are related to hepatitis C virus (HCV) infection, in particular in elderly patients. The Fondazione Italiana Linfomi has recently published a multicentre prospective observational study, the 'Elderly Project', on the outcome of DLBCL in patients aged ≥65 years, evaluated using a simplified comprehensive geriatric assessment. The aim of this study was to compare biological and clinical features of HCV positive (HCV+) with HCV negative (HCV-) cases...
February 2, 2023: British Journal of Haematology
https://read.qxmd.com/read/36712756/a-case-of-mixed-type-ii-cryoglobulinemic-vasculitis-associated-with-marginal-zone-b-cell-lymphoma
#17
Larabe Farrukh, Lisa Rosenberg, Hafiza H Waqar, Javaria Tehzeeb, Muhammad F Akhtar, Pooja Chaukiyal
Our patient is a male in his 40s with a past medical history of sickle cell trait, factor V Leiden mutation, marginal zone B-cell lymphoma, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and sarcoidosis who presented with the complaint of hemoptysis, dyspnea, abdominal pain, arthralgias, peripheral edema of the lower extremities with petechial rash, and oliguria. Investigations revealed acute kidney injury and bilateral transudative pleural effusion. Serology was positive for elevated rheumatoid factor, low complement components, and cryoglobulins...
December 2022: Curēus
https://read.qxmd.com/read/36680223/chronic-hepatitis-c-acute-exacerbation-and-alanine-aminotransferase-flare
#18
REVIEW
Tatsuo Kanda, Naoki Matsumoto, Tomotaka Ishii, Shuhei Arima, Shinji Shibuya, Masayuki Honda, Reina Sasaki-Tanaka, Ryota Masuzaki, Shini Kanezawa, Tsukasa Nishizawa, Yasuhiro Gon, Masahiro Ogawa, Hirofumi Kogure
The hepatitis C virus (HCV) causes acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma, as well as extrahepatic manifestations such as malignant lymphoma. Currently, direct-acting antiviral agents (DAAs) against HCV infection can lead to a sustained virological response (SVR) in almost all HCV-infected patients. In this review article, we discuss acute exacerbation and alanine aminotransferase (ALT) flare in patients with chronic HCV infection. Although acute liver failure caused by HCV infection is rare, careful attention should be paid to the cases with ALT elevation during the natural course of chronic HCV infection...
January 8, 2023: Viruses
https://read.qxmd.com/read/36169798/management-of-mixed-cryoglobulinemia-with-rituximab-evidence-and-consensus-based-recommendations-from-the-italian-study-group-of-cryoglobulinemia-gisc
#19
REVIEW
Luca Quartuccio, Alessandra Bortoluzzi, Carlo Alberto Scirè, Antonio Marangoni, Giulia Del Frate, Elena Treppo, Laura Castelnovo, Francesco Saccardo, Roberta Zani, Marco Candela, Paolo Fraticelli, Cesare Mazzaro, Piero Renoldi, Patrizia Scaini, Davide Antonio Filippini, Marcella Visentini, Salvatore Scarpato, Dilia Giuggioli, Maria Teresa Mascia, Marco Sebastiani, Anna Linda Zignego, Gianfranco Lauletta, Massimo Fiorilli, Milvia Casato, Clodoveo Ferri, Maurizio Pietrogrande, Pietro Enrico Pioltelli, Salvatore De Vita, Giuseppe Monti, Massimo Galli
Cryoglobulinemic vasculitis (CV) or mixed cryoglobulinemic syndrome (MCS) is a systemic small-vessel vasculitis characterized by the proliferation of B-cell clones producing pathogenic immune complexes, called cryoglobulins. It is often secondary to hepatitis C virus (HCV), autoimmune diseases, and hematological malignancies. CV usually has a mild benign clinical course, but severe organ damage and life-threatening manifestations can occur. Recently, evidence in favor of rituximab (RTX), an anti-CD 20 monoclonal antibody, is emerging in CV: nevertheless, questions upon the safety of this therapeutic approach, especially in HCV patients, are still being issued and universally accepted recommendations that can help physicians in MCS treatment are lacking...
February 2023: Clinical Rheumatology
https://read.qxmd.com/read/36164057/abcl-176-the-contribution-of-a-multidisciplinary-team-in-enhancing-thyroid-lymphoma-management
#20
JOURNAL ARTICLE
Ramadan Selim, Gehad Saleh, Dina Ibrahim, Shaimaa El-Ashwah
CONTEXT: Although thyroid lymphoma is an uncommon malignant disease, it is still important to consider in patients with an enlarging neck mass. Primary thyroid lymphoma (PTL) can be cured with chemoimmunotherapy without thyroidectomy, thus avoiding surgical complications as well as hormonal replacement therapy. OBJECTIVE: The study aims to evaluate the clinical features, risk factors, and treatment outcomes of PTL. DESIGN: Retrospective study...
October 2022: Clinical Lymphoma, Myeloma & Leukemia
keyword
keyword
109807
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.