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Dysfuntion endothelial

Bharat Sharma, Abhijeet Saha, N K Dubey, Kanika Kapoor, Anubhuti, Vinita Vijay Batra, Ashish Datt Upadhayay
BACKGROUND: Impaired endothelial function is the initial step in atherogenesis, which is largely responsible for ischaemic heart disease and thrombotic strokes decades later. METHODS: Fourty two children with first episode nephrotic syndrome (FENS) aged 1-16 years and 40 controls were enrolled. Soluble thrombomodulin (sTM), tissue plasminogen activator (t-PA), plasminogen activator inhibitor -1 (PAI-1) and von-willebrand factor (vWF) levels were measured in plasma in FENS, at 12 weeks of drug induced remission and in steroid resistant nephrotic syndrome (SRNS) patients at diagnosis...
April 2014: Atherosclerosis
Tanil Kendirli, Erdal Ince, Ergin Ciftci, Ulker Doğru, Yonca Eğin, Nejat Akar
Endothelial protein C receptor (EPCR) is primarily localized on the endothelial cells of large blood vessels. EPCR enhances activation of protein C by 5- to 20-fold. EPCR appears to be physiologically significant in the control of blood coagulation and inflammation and in the host response to gram-negative sepsis. In this study, the authors evaluated serum-soluble EPCR level in septic children in a pediatric intensive care unit (PICU) in a university hospital. The study was performed between March 2006 and September 2007 and consisted of 39 patients with sepsis and 40 healthy children...
September 2009: Pediatric Hematology and Oncology
Jing Zhang, Bao-yuan Chen, Jin-ying Han, Jie Cao, Mei-nan Guo, Yan Wang
OBJECTIVE: To explore the role of sympathetic nerve activity and vessel endothelial function in the pathogenesis of hypertension in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). METHODS: Based on polysomnography (PSG), blood pressure (BP) and disease history, 93 subjects were divided into four groups: OSAHS with hypertension (OH), OSAHS without hypertension (O), hypertension without OSAHS (H), normal control (N). In addition to the blood pressure measurement, blood samples were collected before and after sleep during the PSG testing night to measure norepinephrine, endothelin, and NO levels...
June 2007: Chinese Journal of Tuberculosis and Respiratory Diseases
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