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Non-healing wounds treatments

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https://www.readbyqxmd.com/read/28109129/vsl-3-probiotic-differently-influence-iec-6-intestinal-epithelial-cell-status-and-function
#1
REVIEW
Benedetta Cinque, Cristina La Torre, Francesca Lombardi, Paola Palumbo, Zoran Evtoski, Silvano Jr Santini, Stefano Falone, Annamaria Cimini, Fernanda Amicarelli, Maria Grazia Cifone
The data here reported introduce the wound-healing assay as a tool for testing probiotics aimed at protecting gastrointestinal mucosal surfaces and to verify the consistency of their manufacturing. At the scope, we compared the in vitro effects of two multi-strain high concentration formulations both commercialized under the same brand VSL#3 but sourced from different production sites (USA and Italy) on a non-transformed small-intestinal epithelial cell line, IEC-6. The effects on cellular morphology, viability, migration, and H2 O2 -induced damage, were assessed before and after the treatment with both VSL#3 formulations...
January 21, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28108895/chronic-wound-healing-a-review-of-current-management-and-treatments
#2
REVIEW
George Han, Roger Ceilley
Wound healing is a complex, highly regulated process that is critical in maintaining the barrier function of skin. With numerous disease processes, the cascade of events involved in wound healing can be affected, resulting in chronic, non-healing wounds that subject the patient to significant discomfort and distress while draining the medical system of an enormous amount of resources. The healing of a superficial wound requires many factors to work in concert, and wound dressings and treatments have evolved considerably to address possible barriers to wound healing, ranging from infection to hypoxia...
January 21, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28106913/efficacy-of-50%C3%A2-hz-electromagnetic-fields-on-human-epidermal-stem-cell-transplantation-seeded-in-collagen-sponge-scaffolds-for-wound-healing-in-a-murine-model
#3
Wen-Fang Bai, Wei-Cheng Xu, Hong-Xiang Zhu, Hong Huang, Bo Wu, Ming-Sheng Zhang
To explore the possible efficacy of electromagnetic fields (EMF) for skin tissue engineering, effects of EMF exposure on epidermal stem cells (ESC) seeded in collagen sponge scaffolds for wound healing in a murine model were investigated. The wound models of a full-thickness defect established with 36 7 ∼ 8-week-old nude mice were randomly divided into three groups: a control group, an ESC-only group, and an ESC with EMF exposure group (frequency of 50 Hz, magnetic induction of 5 mT, 60 min per day for 20 days)...
January 20, 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/28100249/intraoperative-radiation-therapy-iort-in-soft-tissue-sarcoma
#4
REVIEW
Falk Roeder, Robert Krempien
Soft-tissue sarcoma (STS) represent a rare tumor entity, accounting for less than 1% of adult malignancies. The cornerstone of curative intent treatment is surgery with free margins, although the extent of the surgical approach has been subject to change in the last decades. Multimodal approaches usually including radiation therapy have replaced extensive surgical procedures in order to preserve functionality while maintaining adequate local control. However, the possibility to apply adequate radiation doses by external beam radiation therapy (EBRT) can be limited in some situation especially in case of directly adjacent organs at risk with low radiation tolerance...
January 19, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28098885/carboxamide-analog-itr-284-evokes-apoptosis-and-inhibits-migration-ability-in-human-lung-adenocarcinoma-a549-cells
#5
Jai-Sing Yang, Chia-An Lin, Chi-Cheng Lu, Yen-Fang Wen, Fuu-Jen Tsai, Shih-Chang Tsai
Lung adenocarcinoma is the most common type of lung cancer and found in both smokers and non-smokers, but the treatment of lung cancer is limited. ITR-284 has been shown to be a potent carboxamide-derived anticancer agent and to induce apoptosis in leukemia and colon cancer cells. However, little is known whether ITR-284 has anticancer activity in human lung adenocarcinoma cells through induction of apoptosis and suppression of migration in vitro. We showed that ITR-284 inhibited human lung cancer A549 cells using the thiazolyl blue tetrazolium bromide (MTT) assay and evoked apoptosis via the cell cycle distribution at S phase arrest...
January 16, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28077118/malat1-promoted-invasiveness-of-gastric-adenocarcinoma
#6
Na Keum Lee, Jung Hwa Lee, Cristina Ivan, Hui Ling, Xinna Zhang, Chan Hyuk Park, George A Calin, Sang Kil Lee
BACKGROUND: Gastric cancer is the second leading cause of cancer globally, and the mechanism of its pathogenesis is still largely unknown. Recently, non-coding RNAs have been recognized to promote metastasis in various cancers, including gastric cancer. METHODS: We found that metastasis associated lung adenocarcinoma transcript-1 (MALAT1) is upregulated in gastric cancer tissue compared to adjacent normal tissue, as determined by microarray and subsequent qRT-PCR, then investigated the impact of MALAT1 on apoptosis, cell proliferation, and the cell cycle to dissect the carcinogenesis of gastric cancer, and examined mechanisms of invasion and metastasis...
January 11, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28076885/cross-linking-of-porcine-acellular-dermal-matrices-negatively-affects-induced-neovessel-formation-using-platelet-rich-plasma-in-a-rat-model-of-hernia-repair
#7
Joseph S Fernandez-Moure, Jeffrey L Van Eps, Leif Peterson, Beverly A Shirkey, Zachary K Menn, Fernando Cabrera, Azim Karim, Ennio Tasciotti, Bradley K Weiner, Warren A Ellsworth
The degree of crosslinking within acellular dermal matrices (ADM) seems to correlate to neovascularization when used in ventral hernia repair (VHR). Platelet-rich plasma (PRP) enhances wound healing through several mechanisms including neovascularization, but research regarding its effect on soft tissue healing in VHR is lacking. We sought to study the effect of crosslinking on PRP-induced neovascularization in a rodent model of bridging VHR. We hypothesized that ADM crosslinking would negatively affect PRP-induced neovessel formation...
January 11, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28070472/utilizing-the-veraflo%C3%A2-instillation-negative-pressure-wound-therapy-system-with-advanced-care-for-a-case-study
#8
Rita K Driver
BACKGROUND:  Mankind has always suffered wounds throughout time due to trauma, disease, and lifestyles. Many wounds are non-healing and have continued to be challenging. However, utilizing advanced wound care treatments, such as negative pressure wound treatment with instillation and dwell time (NPWTi-d), has proven beneficial. NPWTi-d is indicated in a variety of wounds, such as trauma, surgical, acute, pressure injuries, diabetic foot ulcers, and venous leg ulcers. Bacteria and bioburden interrupts wound healing by increasing the metabolic needs, ingesting, and robbing the necessary nutrients and oxygen...
November 30, 2016: Curēus
https://www.readbyqxmd.com/read/28068967/enterolactone-alters-fak-src-signaling-and-suppresses-migration-and-invasion-of-lung-cancer-cell-lines
#9
Shireen Chikara, Kaitlin Lindsey, Pawel Borowicz, Melpo Christofidou-Solomidou, Katie M Reindl
BACKGROUND: Systemic toxicity of chemotherapeutic agents and the challenges associated with targeting metastatic tumors are limiting factors for current lung cancer therapeutic approaches. To address these issues, plant-derived bioactive components have been investigated for their anti-cancer properties because many of these agents are non-toxic to healthy tissues. Enterolactone (EL) is a flaxseed-derived mammalian lignan that has demonstrated anti-migratory properties for various cancers, but EL has not been investigated in the context of lung cancer, and its anticancer mechanisms are ill-defined...
January 9, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28058557/intraperitoneal-administration-of-plasma-activated-medium-proposal-of-a-novel-treatment-option-for-peritoneal-metastasis-from-gastric-cancer
#10
Shigeomi Takeda, Suguru Yamada, Norifumi Hattori, Kae Nakamura, Hiromasa Tanaka, Hiroaki Kajiyama, Mitsuro Kanda, Daisuke Kobayashi, Chie Tanaka, Tsutomu Fujii, Michitaka Fujiwara, Masaaki Mizuno, Masaru Hori, Yasuhiro Kodera
BACKGROUND: The administration of fluid irradiated with non-equilibrium atmospheric pressure plasma (NEAPP) has attracted much interest as a novel therapeutic method for cancer. The authors previously reported on the efficacy of plasma-activated medium (PAM) for treating cancer cell lines through the induction of apoptosis. In this study, the therapeutic effect of PAM was evaluated in vivo using a peritoneal metastasis mouse model. METHODS: Two gastric cancer cell lines were used in proliferation assays performed to optimize the production of PAM by changing the distance between the plasma source and the medium surface and by altering the volume of irradiated medium...
January 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28043297/-long-non-coding-rna-and-wound-healing
#11
Y Liu, D W Liu
Long non-coding RNA (lncRNA) is a class of RNA molecules longer than 200 nucleotides which does not encode proteins or only encode a few proteins, and it plays important regulatory roles in the expression of genes at the epigenetic, transcriptional, and posttranscriptional levels. The recent reports suggest that lncRNA plays a significant role in growth and development of body, cellular biological processes including in cell proliferation, differentiation, migration, and apoptosis, and regulation of wound healing processes such as re-epithelialization, angiogenesis, and scar formation...
December 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28031461/heparan-sulfate-domains-required-for-fibroblast-growth-factor-1-and-2-signaling-through-fibroblast-growth-factor-receptor-1c
#12
Victor Schultz, Mathew Suflita, Xinyue Liu, Xing Zhang, Yanlei Yu, Lingyun Li, Dixy E Green, Yongmei Xu, Fuming Zhang, Paul L DeAngelis, Jian Liu, Robert J Linhardt
A small library, of well-defined heparan sulfate (HS) polysaccharides, was chemoenzymatically synthesized and used for a detailed structure-activity study of fibroblast growth factor (FGF)1 and FGF2 signaling through FGF receptor (FGFR)1c. The HS polysaccharide tested contained both undersulfated (NA) domains and highly sulfated (NS) domains as well as very well defined non-reducing termini. This study examines differences in the HS selectivity of the positive canyons of the FGF12-FGFR1c2 and FGF22-FGFR1c2 HS-binding sites of the symmetric FGF2-FGFR2HS2 signal transduction complex...
December 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28027892/venous-arterialisation-for-salvage-of-critically-ischaemic-limbs-a-systematic-review-and-meta-analysis
#13
REVIEW
M A Schreve, C G Vos, A C Vahl, J P P M de Vries, S Kum, G J de Borst, Ç Ünlü
BACKGROUND: Critical limb ischaemia (CLI) is the end stage of peripheral artery disease (PAD) and is associated with high amputation and mortality rates and poor quality of life. For CLI patients with no revascularisation options, venous arterialisation could be a last resort for limb salvage. OBJECTIVE: To review the literature on the clinical effectiveness of venous arterialisation for lower limb salvage in CLI patients with no revascularisation options. METHOD: Different databases were searched for papers published between January 1966 and January 2016...
December 24, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28027682/the-effect-of-achillea-millefolium-and-hypericum-perforatum-ointments-on-episiotomy-wound-healing-in-primiparous-women
#14
Maryam Hajhashemi, Zinat Ghanbari, Minoo Movahedi, Mahmoud Rafieian, Atefeh Keivani, Fedyeh Haghollahi
BACKGROUND: The purpose of this study was assessed the efficacy of Achillea millefolium and Hypericum perforatum ointments on episiotomy wound healing in primiparous women. MATERIALS AND METHODS: This is double blind clinical trial study that was performed on 140 primiparous women. They were randomly divided into four groups each one containing 35 women: 2control groups including non-intervention and placebo ointment; and 2case groups including Hypericum perforatum ointment, and Achillea millefolium ointment...
December 27, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28017866/collagen-tethering-of-synthetic-human-antimicrobial-peptides-cathelicidin-ll37-and-its-effects-on-antimicrobial-activity-and-cytotoxicity
#15
Lindsay D Lozeau, Jonian Grosha, Denis Kole, Fioleda Prifti, Tanja Dominko, Terri A Camesano, Marsha W Rolle
: Wound infections, particularly of chronic wounds, pose a substantial challenge for designing antimicrobial dressings that are both effective against pathogens, and do not interfere with wound healing. Due to their broad-spectrum antimicrobial and immunomodulatory activities, naturally-occurring antimicrobial peptides (AMPs) are promising alternative treatments. However, their cytotoxicity at high concentrations and poor stability hinders their clinical use. To mitigate these undesirable properties, we investigated the effects of tethering human AMP cathelicidin LL37 to collagen, one of the main extracellular matrix proteins in wound sites, secreted by fibroblasts, and in commercially-available wound dressings...
December 22, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/28017831/stress-signals-mediated-by-membranous-glucocorticoid-receptor-activate-plc-pkc-gsk-3%C3%AE-%C3%AE-catenin-pathway-to-inhibit-wound-closure
#16
Ivan Jozic, Sasa Vukelic, Olivera Stojadinovic, Liang Liang, Horacio A Ramirez, Irena Pastar, Marjana Tomic Canic
Glucocorticoids (GCs), key mediators of stress signals, are also potent wound healing inhibitors. To understand how stress signals inhibit wound healing, we investigated the role of membranous glucocorticoid receptor (mbGR) by using cell-impermeable BSA-conjugated Dexamethasone. We found that mbGR inhibits keratinocyte migration and wound closure by activating a Wnt-like PLC/PKC signaling cascade. Rapid activation of mbGR/PLC/PKC further leads to activation of known biomarkers of non-healing found in patients, β-catenin and c-myc...
December 22, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28012407/sequential-delivery-of-chlorhexidine-acetate-and-bfgf-from-plga-glycol-chitosan-core-shell-microspheres
#17
Ming-Mao Chen, Huan Cao, Yuan-Yuan Liu, Yan Liu, Fei-Fei Song, Jing-Di Chen, Qi-Qing Zhang, Wen-Zhi Yang
Wound treatment should meet the challenge both of preventing infection and promoting wound healing. To design a sequential delivery system for wound healing, PLGA-glycol chitosan (GC) core-shell microspheres containing chlorhexidine acetate (CHA) at the GC shell and bFGF in the core of PLGA microspheres were fabricated using emulsion-solvent evaporation method. SEM showed that the microspheres were all spherical in shape with a smooth surface. The average size of PLGA-GC microspheres increased due to the GC coating on the surface...
May 17, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28004288/in-vivo-quantification-of-the-revascularization-of-a-human-acellular-dermis-seeded-with-epcs-and-mscs-in-co-culture-with-fibroblasts-and-pericytes-in-the-dorsal-chamber-model-in-pre-irradiated-tissue
#18
M Vitacolonna, D Belharazem, P Hohenberger, E D Roessner
INTRODUCTION: Transplantation of a cell-seeded graft may improve wound healing after radiotherapy. However, the survival of the seeded cells depends on a rapid vascularization of the graft. Co-culturing of adult stem cells may be a promising strategy to accelerate the vessel formation inside the graft. Thus, we compared the in vivo angiogenic potency of mesenchymal stem cells (MSC) and endothelial progenitor cells (EPC) using dorsal skinfold chambers and intravital microscopy. MATERIALS AND METHODS: Cells were isolated from rat bone marrow and adipose tissue and characterized by immunostaining and flow cytometry...
December 21, 2016: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28004121/pifithrin-%C3%AE-is-efficacious-against-non-small-cell-lung-cancer-via-inhibition-of-heat-shock-protein-70
#19
Yang Zhou, Jingping Ma, Jiahong Zhang, Li He, Jianhua Gong, Cong Long
Heat-shock protein (Hsp) 70, known as a pro-survival protein, is aberrantly expressed in several malignancies. The small molecule 2-phenylethyenesulfonamide (PES), also referred to as pifithrin-μ, is known as an HSP70 inhibitor, which exhibits antitumor activities in a variety of cancer cell lines. However, little is known about its effect on non-small cell lung cancer (NSCLC) cell lines. This study aimed to investigate the effect of PES on human NSCLC cell lines A549 and H460, and explore the possible underlying mechanism of action...
January 2017: Oncology Reports
https://www.readbyqxmd.com/read/27999947/comparison-of-in-vivo-immune-responses-following-transplantation-of-vascularized-and-non-vascularized-human-dermo-epidermal-skin-substitutes
#20
Agnes S Klar, Thomas Biedermann, Claudia Simmen-Meuli, Ernst Reichmann, Martin Meuli
PURPOSE: Autologous bio-engineered dermo-epidermal skin substitutes (DESS) represent an alternative therapeutic option for a definitive treatment of skin defects in human patients. Largely, the interaction of host immune cells with transplanted DESS is considered to be essential for the granulation tissue formation, graft take, and its functionality. The aim of this study was to compare the spatiotemporal distribution and density of host-derived monocytes/macrophages and granulocytes in vascularized (vascDESS) versus non-vascularized DESS (non-vascDESS) in a rat model...
December 20, 2016: Pediatric Surgery International
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