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https://www.readbyqxmd.com/read/29780443/separase-inhibitor-sepin-1-inhibits-foxm1-expression-and-breast-cancer-cell-growth
#1
Nenggang Zhang, Debananda Pati
Sepin-1, a potent non-competitive inhibitor of separase, inhibits cancer cell growth, but the mechanisms of Sepin-1-mediated growth inhibition are not fully understood. Here we report that Sepin-1 hinders growth of breast cancer cells, cell migration, and wound healing. Inhibition of cell growth induced by Sepin-1 in vitro doesn't appear to be through apoptosis but rather due to growth inhibition. Following Sepin-1 treatment caspases 3 and 7 are not activated and Poly (ADP-ribose) polymerase (Parp) is not cleaved...
2018: Journal of Cancer Science & Therapy
https://www.readbyqxmd.com/read/29775839/veterinary-applications-of-pulsed-electromagnetic-field-therapy
#2
REVIEW
James S Gaynor, Sean Hagberg, Blake T Gurfein
Pulsed electromagnetic field (PEMF) therapy can non-invasively treat a variety of pathologies by delivering electric and magnetic fields to tissues via inductive coils. The electromagnetic fields generated by these devices have been found to affect a variety of biological processes and basic science understanding of the underlying mechanisms of action of PEMF treatment has accelerated in the last 10 years. Accumulating clinical evidence supports the use of PEMF therapy in both animals and humans for specific clinical indications including bone healing, wound healing, osteoarthritis and inflammation, and treatment of post-operative pain and edema...
May 7, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29774372/-optical-coherence-tomography-for-skin-pathologies
#3
REVIEW
J Welzel, S Schuh
Optical coherence tomography (OCT) has become established in routine diagnosis in dermatology only in the last few years. The reason is that the skin is a challenge for OCT as a strong scattering medium, because only a very small proportion of photons is reflected and can be used for imaging. In addition, in most cases a visual assessment or a biopsy is sufficient. Nevertheless, the main field of application in dermatology is the diagnostics of epithelial skin tumors. The OCT is suitable for the early recognition of small, clinically and light microscopically unspecific basal cell carcinomas as well as for the differential diagnosis of other tumors and precancerous lesions...
May 17, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29768374/treatment-of-multiple-refractory-ankle-ulcerations-in-thromboangiitis-obliterans-a-case-report
#4
Zheng-Hao Huang, San-Yuan Kuo, Yu-Hsiang Chiu, Hsiang-Cheng Chen, Chun-Chi Lu
RATIONALE: Thromboangiitis obliterans (TAOs, or Buerger's disease) present as a non-atherosclerotic segmental occlusive vasculitis within medium- and small-sized blood vessels. TAO frequently occurs in young adults and is associated with cigarette smoking. At present, there are no accurately defined treatments for TAO. PATIENT CONCERNS: A 34-year-old Asian woman with a 20-year history of heavy cigarette smoking and recurrent, small, and self-limited lower limb ulcerations since adolescence, presented with persisting unhealed ulcerations on both ankles for 6 months...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29768262/mir-598-suppresses-invasion-and-migration-by-negative-regulation-of-derlin-1-and-epithelial-mesenchymal-transition-in-non-small-cell-lung-cancer
#5
Fengming Yang, Ke Wei, Zhiqiang Qin, Weitao Liu, Chuchu Shao, Chaoshan Wang, Ling Ma, Mengyan Xie, Yongqian Shu, Hua Shen
BACKGROUND/AIMS: MicroRNAs regulate a wide range of biological processes of non-small cell lung cancer (NSCLC). Although miR-598 has been reported to act as a suppressor in osteosarcoma and colorectal cancer, the physiological function of miR-598 in NSCLC remains unknown. In this study, the role of miR-598 in NSCLC was investigated. METHODS: Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to estimate the expression of miR-598 and Derlin-1 (DERL1) in both NSCLC tissues and cell lines...
May 11, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29763936/synergistic-inhibition-of-thalidomide-and-icotinib-on-human-non-small-cell-lung-carcinomas-through-erk-and-akt-signaling
#6
Xiang Sun, Yang Xu, Yi Wang, Qian Chen, Liu Liu, Yangyi Bao
BACKGROUND Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have been widely used in the treatment of non-small cell lung cancer (NSCLC) patients with sensitive EGFR mutations. However, the survival of patients with EGFR-TKI administration is limited by the inevitable development of acquired drug resistance. Recently, multi-targeted drugs combination has been shown to be a promising strategy to improve the efficacy of EGFR-TKI treatment and enable the reduction of drug resistance in NSCLC...
May 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29761573/using-fat-to-fight-disease-a-systematic-review-of-non-homologous-adipose-derived-stromal-stem-cell-therapies
#7
REVIEW
Marjorie E Bateman, Amy L Strong, Jeffrey M Gimble, Bruce A Bunnell
OBJECTIVE: The objective of this review is to describe the safety and efficacy of ASC and SVF in treating common diseases and the next steps in research that must occur prior to clinical use. EVIDENCE REVIEW: Pubmed, Ovid Medline, Embase, Web of Science, and the Cochrane Library were searched for articles about use of SVF or ASC for disease therapy published between 2012 and 2017. One meta-analysis, 2 randomized controlled trials, and 16 case series were included, representing 844 human patients...
May 15, 2018: Stem Cells
https://www.readbyqxmd.com/read/29755977/wearable-technology-for-chronic-wound-monitoring-current-dressings-advancements-and-future-prospects
#8
REVIEW
Matthew S Brown, Brandon Ashley, Ahyeon Koh
Chronic non-healing wounds challenge tissue regeneration and impair infection regulation for patients afflicted with this condition. Next generation wound care technology capable of in situ physiological surveillance which can diagnose wound parameters, treat various chronic wound symptoms, and reduce infection at the wound noninvasively with the use of a closed loop therapeutic system would provide patients with an improved standard of care and an accelerated wound repair mechanism. The indicating biomarkers specific to chronic wounds include blood pressure, temperature, oxygen, pH, lactate, glucose, interleukin-6 (IL-6), and infection status...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29752091/tunable-sequential-drug-delivery-system-based-on-chitosan-hyaluronic-acid-hydrogels-and-plga-microspheres-for-management-of-non-healing-infected-wounds
#9
Jinjian Huang, Jianan Ren, Guopu Chen, Zongan Li, Yan Liu, Gefei Wang, Xiuwen Wu
Treatment of non-healing infected wounds is an arduous task in clinical practice. Early antibacterial strategy and subsequent promotion of granulation tissue growth facilitate to cure the wounds. For this purpose, we fabricated a sequential drug delivery system by incorporation of an injectable hydrogel with porous PLGA microspheres. Vancomycin was linked to the injectable hydrogel via the reversible Schiff's base reaction, and VEGF were encapsulated into PLGA microspheres. After adding vancomycin, the strength and elasticity of the hydrogel were improved, and the gelation time was shortened...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29750093/laser-phototherapy-induces-angiogenesis-in-the-periodontal-tissue-after-delayed-tooth-replantation-in-rats
#10
Felipe-de Souza Matos, Fernanda-de Jesus Godolphim, Ricardo-Luiz-Cavalcanti Albuquerque-Júnior, Luiz-Renato Paranhos, Sigmar-de Mello Rode, Cláudio-Antonio-Talge Carvalho, Maria-Amália-Gonzaga Ribeiro
Background: Laser phototherapy (LPT) has been suggested as a new therapeutic tool to improve the repair of replanted teeth. However, its effects and mechanism of action are not yet completely understood. Objectives: This study evaluated histologically the effect of laser phototherapy (LPT) λ808 and λ660 nm on angiogenesis in the periodontal tissue of replanted teeth in rats. Material and Methods: Twenty maxillary right incisors were extracted from twenty Wistar rats and randomly assigned to four groups (n = 5): PN - teeth were stored in paper napkin for 45 min; WM - teeth were immersed in 20 ml of UHT whole cow milk for 45 min; PNL and WML - teeth received the same treatment described for PN and WM, respectively, plus LPT at λ808 and λ660 nm...
April 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29746904/benzo-a-pyrene-promotes-migration-invasion-and-metastasis-of-lung-adenocarcinoma-cells-by-upregulating-tgif
#11
Haiyan Yang, Hongsheng Zhang, Teng Pan, Haiyu Wang, Yadong Wang
This study aimed to investigate the potential roles of TG-interacting factor (TGIF) in benzo(a)pyrene (BaP)-induced migration, invasion, and metastasis of lung adenocarcinoma cells. Cells were treated with different concentrations of BaP. MTT assays were used to measure cell proliferation. Quantitative real-time polymerase chain reaction (qRT-PCR) and immunoblots were applied to measure the TGIF expression. A dual-luciferase reporter gene assay was performed to assess the effects of BaP on TGIF promoter-driven reporter gene expression...
May 7, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29745320/honey-an-effective-regenerative-medicine-product-in-wound-management
#12
Simona Martinotti, Marcela Bucekova, Juraj Majtan, Elia Ranzato
Honey has successfully been used in treatment of a broad spectrum of injuries including burns and non-healing wounds. It acts as antibacterial and anti-biofilm agent with anti/pro-inflammatory properties. However, besides these traditional properties, recent evidence suggests that honey is also an immunomodulator in wound healing and contains several bee and plant-derived components that may speed up the wound healing and tissue regeneration process. Identifying their exact mechanism of action allows better understanding of honey healing properties and promotes its wider translation into clinical practice...
May 10, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29738295/antibiotic-resistance-and-biofilm-tolerance-a-combined-threat-in-the-treatment-of-chronic-infections
#13
Philip G Bowler
Since the introduction of antibiotics into human medicine in the 1940's, antibiotic resistance has emerged at an alarming rate and is now a major threat to public health. This problem is amplified by pathogenic bacteria existing most commonly in biofilm form, creating additional bacterial tolerance to antimicrobial agents. Biofilm is now considered to be a primary cause of chronic infection, and antibiotic-resistant bacteria are prevalent in biofilm form. In particular, chronic non-healing wounds commonly harbour complex polymicrobial, pathogenic biofilm that is tolerant to systemic and topical antimicrobial therapy...
May 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29731692/amount-and-distribution-of-selected-biologically-active-factors-in-amniotic-membrane-depends-on-the-part-of-amnion-and-mode-of-childbirth-can-we-predict-properties-of-amnion-dressing-a-proof-of-concept-study
#14
Małgorzata Litwiniuk, Małgorzata Radowicka, Alicja Krejner, Anna Śladowska, Tomasz Grzela
Aim of the study: The amniotic membrane is used as a dressing material, e.g. in ocular surgery or treatment of non-healing wounds. Of note, results of previous studies differ significantly, presumably due to the biological properties of amnion. Some authors suggest that these properties may depend on inter-donor variations, as well as the method of delivery. The aim of our study was to analyse the content of selected factors important for tissue regeneration in various areas of amnion samples originating from elective caesarean sections and on-term natural deliveries...
2018: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29730283/photodynamic-therapy-as-an-alternative-to-antibiotic-therapy-for-the-treatment-of-infected-leg-ulcers
#15
REVIEW
Aleksandra Kawczyk-Krupka, Barbara Pucelik, Anna Międzybrodzka, Aleksander Sieroń, Janusz M Dąbrowski
Infected leg ulcers are painful, debilitating and immensely reducing patient's quality of life, therefore they are becoming a more and more significant clinical and socioeconomic problems nowadays. Increasing resistance to antibiotics, drugs and therapies is one of the most urgent challenge in medicine worldwide and requires searching for a new, innovative and more efficient medical strategies. One of the opportunities for the cure of leg ulcers is photodynamic inactivation (PDI), that has been widely used in the treatment of various bacterial, fungal and viral infections...
May 3, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29725765/treatment-of-acute-achilles-tendon-rupture-with-a-standardised-protocol
#16
Heidi Haapasalo, Ulla Peltoniemi, Heikki-Jussi Laine, Pekka Kannus, Ville M Mattila
INTRODUCTION: A treatment protocol favouring non-operative treatment and based on early weight-bearing and early range-of-motion exercises was implemented in standard clinical care of a level I trauma clinic. MATERIALS AND METHODS: All patients treated due to acute Achilles tendon rupture between 2008 and 2014 were included in the study (n = 411). The patient records were retrospectively evaluated. RESULTS: The mean age of patients was 47 (range 17-88) years...
May 3, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29723492/microbial-host-interactions-and-impaired-wound-healing-in-mice-and-humans-defining-a-role-for-bd14-and-nod2
#17
Helen Williams, Laura Campbell, Rachel A Crompton, Gurdeep Singh, Brian J McHugh, Donald J Davidson, Andrew J McBain, Sheena M Cruickshank, Matthew J Hardman
Chronic wounds cause significant patient morbidity and mortality. A key factor in their etiology is microbial infection, yet skin host-microbiota interactions during wound repair remain poorly understood. Microbiome profiles of non-infected human chronic wounds are associated with subsequent healing outcome. Furthermore, poor clinical healing outcome was associated with increased local expression of the pattern recognition receptor NOD2. To investigate NOD2 function in the context of cutaneous healing, we treated mice with the NOD2 ligand muramyl dipeptide (MDP) and analyzed wound repair parameters and expression of anti-microbial peptides...
April 30, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29720137/upregulation-of-bone-morphogenetic-protein-1-is-associated-with-poor-prognosis-of-late-stage-gastric-cancer-patients
#18
Yung-Yu Hsieh, Shui-Yi Tung, Hung-Yu Pan, Chih-Wei Yen, Huang-Wei Xu, Yi-Fang Deng, Ying-Jhen Lin, Wan-Ting Hsu, Cheng-Shyong Wu, Chin Li
BACKGROUND: Gastric cancer is the eighth most common cancer in Taiwan, with a 40% 5-year survival rate. Approximately 40% of patients are refractory to chemotherapy. Currently, the anti-HER2 therapy is the only clinically employed targeted therapy. However, only 7% patients in Taiwan are HER2-positive. Identifying candidate target genes will facilitate the development of adjuvant targeted therapy to increase the efficacy of gastric cancer treatment. METHODS: Clinical specimens were analyzed by targeted RNA sequencing to assess the expression levels of target genes...
May 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29705993/directing-adipose-derived-stem-cells-into-keratinocyte-like-cells-impact-of-medium-composition-and-culture-condition
#19
L Petry, S Kippenberger, M Meissner, J Kleemann, R Kaufmann, U M Rieger, S Wellenbrock, G Reichenbach, N Zöller, E Valesky
BACKGROUND: Adipose-derived stem cells (ASC) are known to transdifferentiate into a wide range of different cell species in vitro including along the epidermal lineage. This property makes them a promising tool for regenerative medicine in order to restore the epidermal barrier. OBJECTIVE: The present study is dedicated to identify in vitro conditions enabling transdifferentiation to a keratinocyte-like phenotype. Especially, the impact of different culture conditions (media compositions, 2D-, 3D-cultures) and extracellular matrix (ECM) molecules was evaluated...
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29704386/autologous-mononuclear-cells-from-different-sources-are-seen-to-improve-wound-healing-in-patients-with-haematological-malignancies
#20
W F Wan Jamaludin, F Mohamad Yusoff, N A Ismail, M R Mohd Idris, S Palaniappan, C K K Ng, N Abdullah, S Z A Zaider, S F S Abdul Wahid
INTRODUCTION: Immunosuppressive state due to haematological malignancies and chemotherapy may cause disruption to wound healing despite optimum conventional treatment and standard wound dressing. Non-healing wounds are predisposed to infection whereas chemotherapy dose reductions or interruptions are associated with poor survival. BACKGROUND: Mononuclear cells contain progenitor cells including haematopoietic and mesenchymal stem cells, endothelial progenitor cells and fibroblasts which facilitate wound healing through cytokines, growth factor secretions, cell-cell interactions and provision of extracellular matrix scaffolding...
April 2018: Malaysian Journal of Pathology
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