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Non-healing wounds treatments

Guangxin Li, Haishan Lin, Ruyue Tian, Pengfei Zhao, Yongjie Huang, Xinqiao Pang, Lei Zhao, Bangwei Cao
Background: Radiotherapy is a standard treatment for a significant fraction of cancer patients. Nonetheless, to this day radiation resistance is a key impediment in gastric cancer (GC) treatment. Moreover, GC is characterized by its substantial neo-angiogenesis, driven by high levels of vascular endothelial growth factor (VEGF) correlated with the presence of stomach cancer. The aim of our study was to address if VEGFR inhibitors treatments impact the negative effect of radiotherapy regiments of gastric cancer...
2018: Journal of Cancer
Rakia Saidi, Ferdaws Ghrab, Rim Kallel, Abdelfattah El Feki, Tahya Boudawara, Christophe Chesné, Emna Ammar, Raoudha Mezghani Jarraya
The aerial part of Clematis flammula (Ranunculaceae) has been traditionally used in the treatment of skin diseases including mycotic infection in the Tunisian traditional medicine. The study was undertaken to extract and determine the essential oil chemical composition of Clematis flammula aerial parts and to assess the potential of anemonin in wound healing on mechanically wounded wistar rats. The essential oil was obtained by hydrodistillation and analyzed by GC-MS. Anemonin was isolated and then incorporated as active in a cream for which the cytotoxicity was evaluated by methyl thiazolyl tetrazolium (MTT)-based colorimetric assay...
2018: Journal of Oleo Science
Jianming Guo, Haidi Hu, Jolanta Gorecka, Hualong Bai, Hao He, Roland Assi, Toshihiko Isaji, Tun Wang, Ocean Setia, Lara Lopes, Yongquan Gu, Alan Dardik
We have previously shown that bone marrow-derived mesenchymal stem cells (BMSC) accelerate wound healing in a diabetic mouse model. We hypothesized that adipose tissue-derived stem cells (ADSC), of greater translational potential to human therapy, similarly improve diabetic wound healing. In this study, in vitro, the characterization and function of murine ADSC and BMSC, or human diabetic and non-diabetic ADSC were evaluated by flow cytometry, cell viability, and VEGF expression. In vivo, biomimetic collagen scaffolds containing murine ADSC or BMSC were used to treat diabetic wounds on mice, and human diabetic ADSC or non-diabetic ADSC were used to treat back wounds on nude mice; wound healing was evaluated by area, local VEGF expression, and angiogenesis...
November 7, 2018: American Journal of Physiology. Cell Physiology
Kristian Wende, Thomas von Woedtke, Klaus-Dieter Weltmann, Sander Bekeschus
Reactive oxygen and nitrogen species deposited by cold physical plasma are proposed as predominant effectors in the interaction between discharge and biomedical application. Most reactive species found in plasma sources are known in biology for inter- and intracellular communication (redox signaling) and mammalian cells are equipped to interpret the plasma derived redox signal. Such, considerable effort has been put on the investigation of potential clinical applications and the underlying mechanism, with a special emphasis on conditions orchestrated significantly via redox signaling...
November 1, 2018: Biological Chemistry
Gabrielle Marconi Zago Ferreira Damke, Raquel Pantarotto Souza, Maiara Camotti Montanha, Edilson Damke, Renato Sonchini Gonçalves, Gabriel Batista Cesar, Elza Kimura, Wilker Caetano, Noboru Hioka, Marcia Edilaine Lopes Consolaro
BACKGROUND: Breast cancer is the most relevant kind of cancer and the second cause of cancer- related deaths among women in general. Currently, there is no effective treatment for breast cancer although advances in its initial diagnosis and treatment available. Therefore, the value of novel anti-tumor therapeutic modalities remains an immediate unmet need in clinical practice. Following our previous work regarding to the properties of the Pluronics with different photosensitizer (PS) for photodynamic therapy (PDT), in this study we aimed to evaluate the efficacy of supersaturated hypericin (HYP) encapsulated on Pluronic® P123 (HYP/P123) against breast cancer cells (MCF-7) and non-tumorigenic breast cells (MCF-10A)...
November 1, 2018: Anti-cancer Agents in Medicinal Chemistry
Anca Bordianu, Florin Bobircă, Traian Pătraşcu
Background: According to the World Health Organization, cases of diabetes have risen from 108 million in 1980 to 422 million in 2014, with a more rapid rising in middle- and low-income countries. Diabetes causes yearly approximately 1.6 million deaths, and is a major cause of heart attacks, stroke, kidney failure, blindness and lower limb amputation. This article provides information on the treatment of a frequent complication related to diabetes, namely toe/ partial foot amputation. Broad, deep operative defects of the diabetic foot represent a reconstructive challenge...
2018: Chirurgia
Yoshihito Yamada, Yuhki Ueda, Yuki Ashizuka, Kei Hashimoto, Keisuke Tabara, Takamichi Kitano, Mika Fujikawa, Yusuke Kumagai, Tatsumi Matsumoto
When selecting external medicines for the treatment of skin diseases, it is thought to be very important to consider differences in characteristics of their bases, because the bases may influence the clinical efficacy of the medicines. In this study, we investigated whether the differences in characteristics of three kinds of bases, white petrolatum, macrogol ointment, and aqueous gel affect wound healing. In vitro moisture permeability tests demonstrated that these bases have different characteristics in coatability and water retentivity, with the rank order of the intensity of coatability as white petrolatum>macrogol ointment>aqueous gel, and that of water retentivity as macrogol ointment>white petrolatum>aqueous gel...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Dominique Sternadt Alexandre-Ramos, Amandda Évelin Silva-Carvalho, Mariella Guimarães Lacerda, Teresa Raquel Tavares Serejo, Octávio Luiz Franco, Rinaldo Wellerson Pereira, Juliana Lott Carvalho, Francisco Assis Rocha Neves, Felipe Saldanha-Araujo
LL-37 is a host-defense peptide (HDP) and exerts a broad spectrum of microbicidal activity against bacteria, fungi, and viral pathogens. This peptide also interacts with human cells and influences their behavior, promoting angiogenesis, wound healing, immunomodulation, and affecting apoptosis. Lately, significant advances have been achieved regarding the elucidation of underlying mechanisms related to LL-37 effects over neutrophil and monocytes. However, how T-cells respond to LL-37 stimulation is still largely unknown...
October 9, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Parastoo Pourali, Behrooz Yahyaei
PURPOSE: Although alginate has been known to be a good wound dressing, it does not have antimicrobial properties, has low availability, and is expensive. In order to overcome these problems, this study was conducted, where the extraction of this material from an available small factory Pseudomonas aeruginosa and the improvement of its wound healing property by its combination with herb extract, Alhagi maurorum, done. METHODS: Nineteen P. aeruginosa strains were isolated and identified from burned skin and one isolated strain with the highest ability of alginate production was selected...
October 29, 2018: Dermatologic Therapy
Chiharu Fujihara, Yu Kanai, Risa Masumoto, Jirouta Kitagaki, Masahiro Matsumoto, Satoru Yamada, Tetsuhiro Kajikawa, Shinya Murakami
Fibroblast growth factor-2 (FGF-2) stimulates periodontal regeneration by a broad spectrum of effects on periodontal ligament (PDL) cells, such as proliferation, migration, and production of extracellular matrix. A critical factor in the success of periodontal regeneration is the rapid resolution of inflammatory responses in the tissue. We explored an anti-inflammatory effect of FGF-2 during periodontal regeneration and healing. We found that FGF-2 on mouse periodontal ligament cells (MPDL22) markedly downregulated CD40 expression, a key player of inflammation...
October 28, 2018: Journal of Cellular Physiology
Ricardo Ginestal, Bárbara Perez-Köhler, Paloma Pérez-López, Marta Rodríguez, Gemma Pascual, David Cebrián, Juan M Bellón, Francisca García-Moreno
In this study, rat models of wound closure by first and second intention were developed to evaluate the influence that two immunosuppressants for treating multiple sclerosis (fingolimod, azathioprine) have on wound healing. Sixty-three Sprague-Dawley rats were daily treated with fingolimod (0.6 mg/kg), azathioprine (2.5 mg/kg) or placebo (saline). Following 6 weeks of treatment, a linear incision (1.5 cm) or a circular excisional defect (diameter 1.5 cm) was made on the dorsal skin. The treatments were uninterrupted and after 7 days (incisional) or 21 days (incisional, excisional), animals were euthanized (n = 7 per group and time-point)...
October 28, 2018: Wound Repair and Regeneration
Wael N Hozzein, Gamal Badr, Badr M Badr, Ahmed Allam, Ahmad Al Ghamdi, Mohammed A Al-Wadaan, Noori S Al-Waili
Impaired wound healing is a serious complication of diabetes that negatively affects the patient's socioeconomic life. Multiple mechanisms contribute to impaired diabetic wound healing including deficient recruitment of wound macrophages/neutrophils and impaired neovascularization. Bee venom (BV) has been used as an anti-inflammatory agent for the treatment of several diseases. Nevertheless, the impacts of BV on the diabetic wound healing have been poorly studied. In the present study, we investigated the molecular mechanisms underlying BV treatment on diabetic wound healing in a type I diabetic mouse model...
November 2018: Molecular Immunology
Ryan S Din, William G Tsiaras, David G Li, Arash Mostaghimi
INTRODUCTION: Pyoderma gangrenosum (PG) is a neutrophilic dermatosis commonly treated with steroid immunosuppression. The utility of dapsone as a non-immunosuppressive treatment for PG has been reported in case reports and series. We sought to evaluate the response and tolerability of concurrent systemic dapsone therapy for treating PG. METHODS: We reviewed PG patients treated with systemic dapsone at Massachusetts General Hospital and Brigham and Women's Hospital from 2000-2015...
October 1, 2018: Journal of Drugs in Dermatology: JDD
Jeong-Geon Mun, Ji-Ye Kee, Yo-Han Han, Sullim Lee, Seong-Hwan Park, Hee Dong Jeon, Seung-Heon Hong
Galla Rhois is a commonly used medicine in East Asia for the treatment of several diseases. However, the effects of Galla Rhois on the metastasis of colorectal cancer (CRC) and the underlying molecular mechanisms have not been studied. We investigated the anti‑metastatic properties of Galla Rhois water extract (GRWE) on metastatic CRC cells. The effect of GRWE on the viability of colon 26 (CT26) cells was evaluated using WST‑8 assay. Annexin V assay and western blot analysis were performed to elucidate the underlying molecular mechanisms involved in apoptosis...
October 22, 2018: Oncology Reports
Md Tipu Sultan, Ok Joo Lee, Soon Hee Kim, Hyung Woo Ju, Chan Hum Park
Silk fibroin (SF), a natural bioproduct, has been extensively used in biological and biomedical fields including wound healing due to its robust biocompatibility, less immunogenic, non-toxic, non-carcinogenic, and biodegradable properties. SF in different morphologic forms, such as hydrogels, sponges, films, electrospun nanofiber mats, and hydrocolloid dressings, have been successfully used for therapeutic use as wound dressings to induce the healing process. SF has also been known to promote wound healing by increasing the cell growth, proliferation, and migration of different cells types involved in the different phase of wound healing process...
2018: Advances in Experimental Medicine and Biology
Bo Pan, Haibo Han, Lina Wu, Ying Xiong, Jianzhi Zhang, Bin Dong, Yue Yang, Jinfeng Chen
Background: It is clearly necessary to discover prognostic biomarkers to identify stage I patients at risk of recurrence and give them timely postoperative treatment. Materials and methods: Data of stage I lung adenocarcinoma were retrieved from four gene series in Gene Expression Omnibus (GEO) database (GSE50081, GSE30219, GSE37745, and GSE13213). Partek Genomics Suite software was used to identify survival-related genes for finding candidate indicators for early-stage patients at risk of recurrence...
2018: OncoTargets and Therapy
Hakan Duran, Fulya Üstün Alkan, Muzaffer Başak Ulkay, Selcan Karakuş, Abit Aktaş, Tuba Şişmanoğlu
We aimed to test the adsorption of the methylene blue (MB) on HSEPCGUM as a dye and also to test the obtained ternary biocomposite substance (HSEPCGUM-MB) on wound healing. Hollow silica spheres (HSS) are used in the pharmaceutical and biochemical field, because of low toxic, highly biocompatible and mechanically stable by large surface areas. HSS was obtained by mechanochemistry method. The obtained HSS was treated with epichlorohydrin to carry out an epoxidation process (HSEPC). Then, HSEPC was functionalized by treatment with gum arabic (HSEPCGUM)...
October 18, 2018: International Journal of Biological Macromolecules
Tsung-Lin Cheng, Po-Ku Chen, Wei-Kai Huang, Cheng-Hsiang Kuo, Chia-Fong Cho, Kuan-Chieh Wang, Guey-Yueh Shi, Hua-Lin Wu, Chao-Han Lai
Plasminogen (Plg) and thrombomodulin (TM) are glycoproteins well known for fibrinolytic and anticoagulant functions, respectively. Both Plg and TM are essential for wound healing. However, their significance during the reparative process was separately demonstrated in previous studies. Here, we investigate the interaction between Plg and epithelial TM and its effect on wound healing. Characterization of the wound margin revealed that Plg and TM were simultaneously upregulated at the early stage of wound healing and the two molecules were bound together...
October 19, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
Yang Wang, Chunhui Zheng, Teng Li, Rui Zhang, Yang Wang, Jiaxin Zhang, Qingsi He, Zuocheng Sun, Xinsheng Wang
Gastric cancer is one of the leading causes of cancer-associated mortality and has a high tendency to metastasize, making it a priority to develop novel diagnostic and treatment methods at the early stages. The present study investigated the role of a newly-discovered long non-coding RNA, Z38, in gastric cancer cell proliferation, metastasis and apoptosis. It was observed that Z38 was upregulated in tissues from patients with gastric cancer as well as in cultured gastric cancer cells. Knockdown of Z38 decreased the cell proliferative rate, as evidenced by colony formation assays and cell proliferation assays...
November 2018: Oncology Letters
Zhenmi Liu, Jo C Dumville, Robert J Hinchliffe, Nicky Cullum, Fran Game, Nikki Stubbs, Michael Sweeting, Frank Peinemann
BACKGROUND: Foot wounds in people with diabetes mellitus (DM) are a common and serious global health issue. People with DM are prone to developing foot ulcers and, if these do not heal, they may also undergo foot amputation surgery resulting in postoperative wounds. Negative pressure wound therapy (NPWT) is a technology that is currently used widely in wound care. NPWT involves the application of a wound dressing attached to a vacuum suction machine. A carefully controlled negative pressure (or vacuum) sucks wound and tissue fluid away from the treated area into a canister...
October 17, 2018: Cochrane Database of Systematic Reviews
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