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Non-healing wounds treatments

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https://www.readbyqxmd.com/read/29147163/self-care-based-treatment-using-ordinary-elastic-bandages-for-venous-leg-ulcers
#1
Kotaro Suehiro, Noriyasu Morikage, Takasuke Harada, Makoto Samura, Yuriko Takeuchi, Takahiro Mizoguchi, Kimikazu Hamano
Objective: We aimed to study venous leg ulcer (VLU) healing and recurrence rates of VLU using a self-care-based treatment strategy. Methods: The study included 36 patients (43 legs) who visited our clinic between April 2009 and June 2015 because of non-healing VLUs and who had been treated by us for more than a year (until June 2016). Patients or their caregivers were first provided instructions for performing the "no-intentional-stretch" bandaging technique using ordinary elastic bandages. Wounds were cleansed with tepid water daily, and bandages were re-applied by patients or their caregivers; this was continued until VLUs were healed...
September 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29146183/d-rhamnose-%C3%AE-hederin-inhibits-migration-and-invasion-of-human-breast-cancer-cell-line-mda-mb-231
#2
Lin Cheng, Tian-Song Xia, Liang Shi, Lingyun Xu, Weixian Chen, Yulan Zhu, Qiang Ding
Many natural products have been shown to have inhibitory effects on the metastatic process of various cancers including breast cancer. An active triterpenoid saponin D Rhamnose β-hederin (DRβ-H) from Clematis ganpiniana, has been known induce the apoptosis of breast cancer cells, but the effect of DRβ-H on the metastasis of breast cancer cells is largely unknown. In this study, we demonstrated that a non-cytotoxic concentration of DRβ-H markedly suppressed wound healing migration, migration through the chamber and invasion through the matrigel...
November 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29145520/opposite-effects-of-non-thermal-plasma-on-cell-migration-and-collagen-production-in-keloid-and-normal-fibroblasts
#3
Sung Un Kang, Yeon Soo Kim, Yang Eun Kim, Ju-Kyeong Park, Yun Sang Lee, Hee Young Kang, Jae Won Jang, Jeong Beom Ryeo, Yuijina Lee, Yoo Seob Shin, Chul-Ho Kim
Recent progress in the understanding non-thermal plasma (NTP) properties prompted its application in the treatment of various diseases. However, therapeutic effect of NTP on keloid cells has not been reported previously. We sought to investigate the effect of NTP treatment on keloid by comparing cell migration and collagen production of keloid (KFs) and normal fibroblasts (NFs) and determined the regulatory pathways involved. We assessed NTP effects on cell migration in KFs and NFs by the wound healing assay and measured the expression of the epidermal growth factor receptor (EGFR), signal transducer and activator of transcription-3 (STAT3), and collagen by western blot...
2017: PloS One
https://www.readbyqxmd.com/read/29138509/non-thermal-atmospheric-plasma-ameliorates-imiquimod-induced-psoriasis-like-skin-inflammation-in-mice-through-inhibition-of-immune-responses-and-up-regulation-of-pd-l1-expression
#4
Yun Sang Lee, Myung-Hoon Lee, Hang-Jun Kim, Ho-Ryun Won, Chul-Ho Kim
Plasma medicine is an emerging novel therapeutic field. It has been reported that plasma can kill bacteria, promote wound healing and induce apoptosis of tumor cells. However, the effects of plasma on immune cells and immune related skin diseases have not been well studied. In this study, we demonstrated that non-thermal atmospheric plasma (NTP) treatment could inhibit psoriasis-like skin inflammation in mice. NTP treatment in imiquimod-induced psoriasis-like mouse skin inhibited increases in epithelial cell thickness and expression of pro-inflammatory molecules compared to ones without the NTP treatment...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137157/in-situ-synthesis-of-silver-nanoparticles-in-a-hydrogel-of-carboxymethyl-cellulose-with-phthalated-cashew-gum-as-a-promising-antibacterial-and-healing-agent
#5
Ana Karina Marques Fortes Lustosa, Antônia Carla de Jesus Oliveira, Patrick Veras Quelemes, Alexandra Plácido, Francilene Vieira da Silva, Irisdalva Sousa Oliveira, Miguel Peixoto de Almeida, Adriany das Graças Nascimento Amorim, Cristina Delerue-Matos, Rita de Cássia Meneses de Oliveira, Durcilene Alves da Silva, Peter Eaton, José Roberto de Souza de Almeida Leite
Silver nanoparticles have been shown to possess considerable antibacterial activity, but in vivo applications have been limited due to the inherent, but low, toxicity of silver. On the other hand, silver nanoparticles could provide cutaneous protection against infection, due to their ability to liberate silver ions via a slow release mechanism, and their broad-spectrum antimicrobial action. Thus, in this work, we describe the development of a carboxymethyl cellulose-based hydrogel containing silver nanoparticles...
November 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29136761/galangin-inhibits-the-cell-progression-and-induces-cell-apoptosis-through-activating-pten-and-caspase-3-pathways-in-retinoblastoma
#6
Wen-Wei Zou, Su-Ping Xu
Retinoblastoma is reported as a rare cancer that occurs during childhood. Although several treatments are available for retinoblastoma, there is a need for alternative new treatment modalities for retinoblastoma with better safety and efficacy profile. Galangin (3,5,7-trihydroxyflavone), is a flavonoid compound, which is found in high concentration in lesser galangal. Galangin has been reported to have various bioactivities, including anti-inflammation, anti-oxidative stress and anti-cancer through various pathways...
November 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29131990/non-thermal-near-infrared-exposure-photobiomodulates-cellular-responses-to-ionizing-radiation-in-human-full-thickness-skin-models
#7
Anke König, Nadja Zöller, Stefan Kippenberger, August Bernd, Roland Kaufmann, Paul G Layer, Anja Heselich
Ionizing and near-infrared radiation are both part of the therapeutic spectrum in cancer treatment. During cancer therapy ionizing radiation is typically used for non-invasive reduction of malignant tissue, while near-infrared photobiomodulation is utilized in palliative medical approaches, e.g. for pain reduction or impairment of wound healing. Furthermore, near-infrared is part of the solar wavelength spectrum. A combined exposure of these two irradiation qualities - either intentionally during medical treatment or unintentionally due to solar exposure - is therefore presumable for cancer patients...
November 10, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29131756/combined-use-of-modulated-ultrasound-and-electric-current-stimulation-for-diabetic-foot-ulcers-a-case-series
#8
T O'Connor, Z Moore, D Patton, P Wilson, C Gillen, M Hughes, A Reilly
OBJECTIVE: Diabetic foot ulcers (DFUs) are a significant challenge in wound care practice. Our aim was to evaluate the combined use of of two therapies, ultrasound and electrostimulation, in the treatment of DFUs. METHOD: This study employed a prospective, non-comparative, case series design, undertaken in a podiatry-led diabetic foot clinic, in an acute hospital setting, in an urban location in Ireland. We recruited patinets with hard-to-heal DFUs who were treated twice a week with combined modulated ultrasound and electric current stimulation...
November 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29131748/a-multicentre-clinical-evaluation-of-a-hydro-responsive-wound-dressing-the-glasgow-experience
#9
H Hodgson, D Davidson, A Duncan, J Guthrie, E Henderson, M MacDiarmid, K McGown, V Pollard, R Potter, A Rodgers, A Wilson, J Horner, M Doran, S Simm, R Taylor, A Rogers, M G Rippon, M Colgrave
OBJECTIVE: Our aim was to assess the effectiveness of hydro-responsive wound dressing (HRWD) in debridement and wound bed preparation of a variety of acute and chronic wounds that presented with devitalised tissue needing removal so that healing may proceed. METHOD: This was a non-comparative evaluation of acute and chronic wounds that required debridement as part of their normal treatment regimen. Clinicians recorded wound changes including a subjective assessment level of devitalised tissue and wound bed preparation, presence of pain, wound status (e...
November 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29131746/topical-oxygen-therapy-promotes-the-healing-of-chronic-diabetic-foot-ulcers-a-pilot-study
#10
P D Hayes, N Alzuhir, G Curran, I M Loftus
OBJECTIVE: Interventions that can heal or reduce diabetic foot ulcer (DFU) size may reduce the incidence of infection and amputation, and reduce associated social and economic costs. Many chronic wounds exhibit a degree of hypoxia and this leads to a reduction in healing processes including cell division and differentiation, angiogenesis, infection prevention, and collagen production. The aim of this pilot study was to assess the effects of a device supplying continuous oxygen ambulatory therapy on healing in chronic DFUs...
November 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29130595/naphthoquinones-a-continuing-source-for-discovery-of-therapeutic-antineoplastic-agents
#11
REVIEW
Han-Yue Qiu, Peng-Fei Wang, Hong-Yan Lin, Cheng-Yi Tang, Hai-Liang Zhu, Yong-Hua Yang
Naturally occurring naphthoquinones, usually in forms of botanical extracts, have been implicated with human life since ancient time, far earlier than their isolation and identification in modern era. The long use history of naphthoquinones has witnessed their functional shift from the original purposes as dyes and ornaments towards medicinal benefits. Hitherto, numerous studies have been carried out to elucidate the pharmacological profile of both natural and artificial naphthoquinones. A number of entities have been identified with promising therapeutic potential...
November 11, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29115450/herbal-prescription-danggui-sayuk-ga-osuyu-senggang-tang-inhibits-tnf-%C3%AE-induced-epithelial-mesenchymal-transition-in-hct116-colorectal-cancer-cells
#12
Kangwook Lee, Sung-Gook Cho, Youn Kyung Choi, Yu-Jeong Choi, Gyu-Ri Lee, Chan-Yong Jeon, Seong-Gyu Ko
Tumor necrosis factor‑α‑mediated (TNF‑α) epithelial‑mesenchymal transition (EMT) is associated with distant metastasis in patients with colorectal cancer with poor prognosis. Although traditional herbal medicines have long been used to treat colorectal cancer, the incidence and mortality in patients with colorectal cancer has continued to increase. Danggui‑Sayuk‑Ga‑Osuyu‑Saenggang‑Tang (DSGOST) has long been used for treatment of chills, while few studies have reported its anticancer effect...
November 7, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29104343/low-intensity-pulsed-ultrasound-lipus-for-the-treatment-of-intervertebral-disc-degeneration
#13
Devante Horne, Peter Jones, Vasant Salgaonkar, Matt Adams, B Arda Ozilgen, Peter Zahos, Xinyan Tang, Ellen Liebenburg, Dezba Coughlin, Jeffrey Lotz, Chris Diederich
Discogenic back pain presents a major public health issue, with current therapeutic interventions limited to short-term symptom relief without providing regenerative remedies for diseased intervertebral discs (IVD). Many of these interventions are invasive and can diminish the biomechanical integrity of the IVDs. Low intensity pulsed ultrasound (LIPUS) is a potential treatment option that is both non-invasive and regenerative. LIPUS has been shown to be a clinically effective method for the enhancement of wound and fracture healing...
January 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29098740/does-non-contact-low-frequency-ultrasound-nlfu-therapy-contribute-to-wound-healing-at-the-molecular-level
#14
Cornelia Wiegand, Kyle Bittenger, Robert D Galiano, Vickie R Driver, Gary W Gibbons
Non-contact low frequency ultrasound (NLFU) is used to treat various types of chronic wounds including venous, diabetic and pressure ulcers. The objective for this sub study of the IN BALANCE RCT VLU trial was to characterize and compare the NLFU treatment group and patients receiving standard of care (SOC) with respect to the effect of the assigned study treatment on content/quantity of inflammatory cytokines and fibrinogen as well as bacteria. Higher mean wound area reduction was observed in the NLFU treatment group (67...
November 2, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29081409/enhanced-expression-of-the-long-non-coding-rna-snhg16-contributes-to-gastric-cancer-progression-and-metastasis
#15
Dongbo Lian, Buhe Amin, Dexiao Du, Wei Yan
This paper aimed to probe into the expression of long non-coding RNA (lncRNA) SNHG16 in human gastric cancer (GC) and its potential tumor biological functions. The expression of lncRNA SNHG16 was detected in GC and adjacent tissues and GC cell lines using qRT-PCR. GC MGC-803 cells were transfected with siRNA of lncRNA SNHG16, as well as blank and negative control. A series of experiments including CCK-8, flow cytometry, transwell, and wound healing assay were adopted to evaluate the effects of lncRNA SNHG16 on cell growth and metastasis...
October 20, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29072688/mir-106a-5p-inhibits-the-cell-migration-and-invasion-of-renal-cell-carcinoma-through-targeting-pak5
#16
Yao-Jie Pan, Lu-Lu Wei, Xiao-Jin Wu, Fu-Chun Huo, Jie Mou, Dong-Sheng Pei
MicroRNA-106a-5p (MiR-106a-5p), a small non-coding RNA, has been reported to be downregulated in astrocytoma, osteosarcoma and colorectal cancer. However, the expression levels and biological function in renal cell carcinoma (RCC) have not been studied yet. In this study, we found that the miR-106a-5p was significantly downregulated in RCC tissues and cell lines, and that overexpression of miR-106a-5p led to decreased cell metastasis ability in a xenograft model. Inhibition of miR-106a-5p in RCC cell lines altered the cell migration, invasion and wound healing abilities...
October 26, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29072193/development-of-poly-1-8-octanediol-co-citrate-and-poly-acrylic-acid-nanofibrous-scaffolds-for-wound-healing-applications
#17
Allison Goins, Vidhya Ramaswamy, Elliott Dirr, Krista Dulany, Sean Irby, Antonio Webb, Josephine Allen
Wound care is one of the leading health care problems in the United States costing billions of dollars yearly. Annually, millions of acute wounds occur due to surgical procedures or traumas such as burns and abrasions, and these wounds can become non-healing due to bacterial infection or underlying pathologies. Current wound care treatments include the use of bioinert constructs combined with topical administration of anti-bacterial agents and growth factors. However, there is a growing need for the development of bioactive wound dressing materials that are able to promote wound healing and the regeneration of healthy tissue...
October 26, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/29062166/growth-factor-functionalized-biomaterial-for-drug-delivery-and-tissue-regeneration
#18
Alex Leonard, Piyush Koria
Elastin like polypeptides (ELPs) are a class of naturally derived and non-immunogenic biomaterials that are widely used in drug delivery and tissue engineering. ELPs undergo temperature-mediated inverse phase transitioning, which allows them to be purified in a relatively simple manner from bacterial expression hosts. Being able to genetically encode ELPs allows for the incorporation of bioactive peptides thereby functionalizing them. Here we report the synthesis of a biologically active epidermal growth factor-ELP (EGF-ELP) fusion protein that could aid in wound healing...
November 2017: Journal of Bioactive and Compatible Polymers
https://www.readbyqxmd.com/read/29058788/significant-skin-tightening-by-closure-of-fractional-ablative-laser-holes
#19
Elisabeth Russe, Martin Purschke, Wikunda Limpiangkanan, William A Farinelli, Ying Wang, Apostolos G Doukas, Fernanda H Sakamoto, Gottfried Wechselberger, Richard Rox Anderson
BACKGROUND AND OBJECTIVE: Ablative fractional laser treatment uses thousands of very small laser beam wounds to damage a fraction of the skin, which stimulates tissue remodeling. Each open micro-wound heals without scarring, but the amount of skin tightening achieved is limited. This animal study was performed to test the hypothesis that immediate temporary closure of fractional laser wounds could increase skin tightening after fractional ablative laser treatment. MATERIALS AND METHODS: Four adult swine were used for the study; 98 square test sites (3 × 3 cm) were tattooed on the abdomen and flanks of each pig...
October 23, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29057562/complications-of-the-neovagina-in-male-to-female-transgender-surgery-a-systematic-review-and-meta-analysis-with-discussion-of-management
#20
REVIEW
Paulette Cutruzzula Dreher, Daniel Edwards, Shaun Hager, Margeaux Dennis, Andie Belkoff, Jamie Mora, Susan Tarry, Kathy L Rumer
Introduction Gender-affirmation surgery is often the final gender-confirming medical intervention sought by those patients suffering from gender dysphoria. In the male-to-female transgendered patient, the creation of aesthetic and functional external female genitalia with a functional vaginal channel is of the utmost importance. The aim of this review and meta-analysis is to evaluate the epidemiology, presentation, management and outcomes of neovaginal complications in the male-to-female transgender reassignment surgery patients...
October 23, 2017: Clinical Anatomy
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