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Non-healing wounds treatments

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https://www.readbyqxmd.com/read/28334027/metformin-inhibits-gastric-cancer-cells-metastatic-traits-through-suppression-of-epithelial-mesenchymal-transition-in-a-glucose-independent-manner
#1
Shiva Valaee, Mohammad Mehdi Yaghoobi, Mehdi Shamsara
Epithelial-mesenchymal transition (EMT), which is mainly recognized by upregulation of mesenchymal markers and movement of cells, is a critical stage occurred during embryo development and spreading cancerous cells. Metformin is an antidiabetic drug used in treatment of type 2 diabetes. EMT inhibitory effect of metformin has been studied in several cancers; however, it remains unknown in gastric cancer. The aim of the present study was to investigate the metformin effects on inhibition of EMT-related genes as well as migration and invasion of AGS gastric cancer cell line...
2017: PloS One
https://www.readbyqxmd.com/read/28326683/restoring-full-thickness-defects-with-spray-skin-in-conjunction-with-dermal-regenerate-template-and-split-thickness-skin-grafting-a-pilot-study
#2
Daniel Hammer, Juan L Rendon, Jennifer Sabino, Kerry Latham, Mark E Fleming, Ian L Valerio
Complex, full-thickness soft tissue defects secondary to large burns, trauma and war-related injuries continue to challenge reconstructive surgeons. To achieve positive surgical outcomes in these patient populations, novel approaches are needed to restore the functional, protective and aesthetic properties of skin. Herein, we provide the first report describing the staged use of a dermal regenerate template (DRT) with a spray-on epidermal regenerative modality (spray skin) in addition to autologous split-thickness skin grafting (STSG) in non-burn trauma and compare these results with those of patients treated with DRT and STSG alone...
March 22, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28319106/a-systematic-review-on-the-impact-of-diabetes-mellitus-on-the-ocular-surface
#3
REVIEW
K Co Shih, K S-L Lam, L Tong
Diabetes mellitus is associated with extensive morbidity and mortality in any human community. It is well understood that the burden of diabetes is attributed to chronic progressive damage in major end-organs, but it is underappreciated that the most superficial and transparent organ affected by diabetes is the cornea. Different corneal components (epithelium, nerves, immune cells and endothelium) underpin specific systemic complications of diabetes. Just as diabetic retinopathy is a marker of more generalized microvascular disease, corneal nerve changes can predict peripheral and autonomic neuropathy, providing a window of opportunity for early treatment...
March 20, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28302404/mesenchymal-stem-cells-derived-mfg-e8-accelerates-diabetic-cutaneous-wound-healing
#4
Akihiko Uchiyama, Sei-Ichiro Motegi, Akiko Sekiguchi, Chisako Fujiwara, Buddhini Perera, Sachiko Ogino, Yoko Yokoyama, Osamu Ishikawa
BACKGROUND: Diabetic wounds are intractable due to complex factors, such as the inhibition of angiogenesis, dysfunction of phagocytosis by macrophages and abnormal inflammatory responses. It is recognized that mesenchymal stem cells (MSCs) promote wound healing in diabetic mice. We previously demonstrated that MSCs produce large amounts of MFG-E8. OBJECT: The objective was to ascertain the role of MSCs-derived MFG-E8 in murine diabetic wounds. METHODS: MFG-E8 WT/KO MSCs or rMFG-E8 were subcutaneously injected around the wound in diabetic db/db mice, and wound areas were analyzed...
March 6, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28294043/polysaccharide-based-materials-associated-with-or-coordinated-to-gold-nanoparticles-synthesis-and-medical-application
#5
Débora P Facchi, Joziel A da Cruz, Elton G Bonafé, Antonio G B Pereira, André R Fajardo, Sandro A S Venter, Johny P Monteiro, Edvani C Muniz, Alessandro F Martins
BACKGROUND: Gold nanoparticles (AuNPs) have enormous potential for application in imaging, diagnosis, and therapies in the medical field. AuNPs are renowned for their localized surface plasmon resonance (LSPR) properties, large surface area, and biocompatibility with body fluids. Further, AuNPs have featured prominently in new methodologies for cancer treatments, like photothermal and imaging therapies. Although AuNPs present enormous potential for application in the medical field, their instability under physiological conditions prevents further uses...
March 9, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28290581/deconvolution-of-heterogeneous-wound-tissue-samples-into-relative-macrophage-phenotype-composition-via-models-based-on-gene-expression
#6
Nicole M Ferraro, Will Dampier, Michael S Weingarten, Kara L Spiller
Macrophages, the primary cell of the innate immune system, act on a spectrum of phenotypes that correspond to diverse functions. Dysregulation of macrophage phenotype is associated with many diseases. In particular, defective transition from pro-inflammatory (M1) to anti-inflammatory (M2) behavior has been implicated as a potential source of sustained inflammation that prevents healing of chronic wounds such as diabetic ulcers. In order to design effective treatments, an understanding of the relative presence of macrophage phenotypes during tissue repair is necessary...
March 14, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28289554/non-coding-rnas-new-players-in-skin-wound-healing
#7
REVIEW
Eva K Herter, Ning Xu Landén
Significance: Wound healing is a basic physiological process that is utilized to keep the integrity of the skin. Impaired wound repair, such as chronic wounds and pathological scars, presents a major health and economic burden worldwide. To date, efficient targeted treatment for these wound disorders is still lacking, which is largely due to our limited understanding of the biological mechanisms underlying these diseases. Research driven around discovering new therapies for these complications is, therefore, an urgent need...
March 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28287292/-long-term-results-after-invasive-treatment-of-critical-limb-ischemia
#8
Zoltán Ruzsa, Ferenc Kuti, Balázs Berta, Károly Tóth, Zoltán Bánsághi, Zoltán Vámosi, Kálmán Hüttl
INTRODUCTION AND AIM: Surgical tibial bypass for critical limb ischemia is associated with significant morbidity, mortality, and graft failure, whereas percutaneous angioplasty and stenting has promising results. The objective of this study was the investigation of the long term results of below-knee percutaneous angioplasty for restoring straight inline arterial flow in patients with critical limb ischemia. METHOD: The clinical and angiographic data of 281 consecutive patients with critical limb ischemia treated by PTA between 2008 and 2011 was evaluated in a prospective register...
March 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28286419/dual-roles-of-extracellular-signal-regulated-kinase-erk-in-quinoline-compound-bpiq-induced-apoptosis-and-anti-migration-of-human-non-small-cell-lung-cancer-cells
#9
Yao Fong, Chang-Yi Wu, Kuo-Feng Chang, Bing-Hung Chen, Wan-Ju Chou, Chih-Hua Tseng, Yen-Chun Chen, Hui-Min David Wang, Yeh-Long Chen, Chien-Chih Chiu
BACKGROUND: 2,9-Bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy] phenyl}-11H-indeno[1,2-c]quinoline-11-one (BPIQ), is a synthetic quinoline analog. A previous study showed the anti-cancer potential of BPIQ through modulating mitochondrial-mediated apoptosis. However, the effect of BPIQ on cell migration, an index of cancer metastasis, has not yet been examined. Furthermore, among signal pathways involved in stresses, the members of the mitogen-activated protein kinase (MAPK) family are crucial for regulating the survival and migration of cells...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28279120/ccl11-promotes-angiogenic-activity-by-activating-the-pi3k-akt-pathway-in-huvecs
#10
Jun Young Park, Yeo Wool Kang, Byung Young Choi, Young Chul Yang, Byung Pil Cho, Won Gil Cho
CCR3, the receptor for CCL11, is expressed on the surface of immune cells and even on non-immune cells. CCL11-CCR3 interactions can promote cell migration and proliferation. In this study, we investigated the effect of CCL11 on angiogenesis in HUVECs and also examined the molecular mechanisms of this process. We found that CCL11 induced mRNA transcription and protein expression of CCR3 in HUVECs. Moreover, the scratch wound healing assay and MTS proliferation assay both demonstrated that CCL11 promotes endothelial cell migration and induces weak proliferation...
March 9, 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28274882/vacuum-sealing-drainage-as-a-pre-surgical-adjunct-in-the-treatment-of-complex-open-hand-injuries-report-of-17-cases
#11
Xiao-Feng Niu, Jian-Hua Yi, Guo-Qin Zha, Jun Hu, Yun-Jiang Liu, Liang-Bao Xiao
BACKGROUND: Few studies have been conducted to explore the use of the vacuum sealing drainage (VSD) technique in complex hand injuries. The aim of this study was to report outcomes in patients with complex hand injuries receiving VSD as a coadjuvant treatment prior to second-stage surgery. METHODS: This case series study retrospectively reviewed the patients who underwent VSD for treatment of hand injuries. Inclusion criteria for the study were: (1) traumatic soft tissue defects of the hand and wrist, accompanied by different degrees of injury and exposure of bone, tendon, or blood vessel; (2) the wound surface of hand and wrist was seriously contaminated and direct wound closure was not possible; and (3) the soft tissues of hand and wrist were seriously lacerated or avulsed, and showed necrosis or acute infection...
March 5, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28271918/platelet-rich-plasma-for-treatment-of-nonscarring-hair-loss-systematic-review-of-literature
#12
Azin Ayatollahi, Hamed Hosseini, Jaleh Gholami, Babak Mirminachi, FaridHossein Firooz, Alireza Firooz
BACKGROUND: Although there are many studies showing the role of platelet rich plasma (PRP) in bone grafts, teeth osteosynthesis, and wound healing, there have been little peer reviewed studies about the safety and efficacy of PRP application in the treatment of hair loss. MATERIALS AND METHODS: In this systematic review, we searched Ovid Medline, Scopus and Web of Knowledge till November 2015 for human studies evaluating the efficacy of PRP for the treatment of noncicatricial alopecia...
March 8, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28271745/very-distal-vein-bypass-in-patients-with-thromboangiitis-obliterans
#13
Achim Neufang, Carolina Vargas-Gomez, Patrick Ewald, Nicolaos Vitolianos, Tolga Coskun, Nael Abu-Salim, Rainer Schmiedel, Peter von Flotow, Savvas Savvidis
BACKGROUND: Surgical revascularization for chronic critical limb ischaemia in patients with thromboangiitis obliterans (TAO) still remains controversial. Generally, besides cessation of smoking, conservative treatment supported by intravenous administration of vasoactive agents is regarded as the treatment of choice, in combination with local wound therapy or minor amputation. PATIENTS AND METHODS: In four male patients (42-47 years) surgical revascularization was chosen as therapy for established gangrene or non-healing ulceration after unsuccessful conservative treatment and cessation of smoking...
March 8, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28266867/an-overview-on-current-issues-and-challenges-of-endothelial-progenitor-cell-based-neovascularization-in-patients-with-diabetic-foot-ulcer
#14
Sushant Kumar Das, Yi Feng Yuan, Mao Quan Li
Diabetic foot ulcer's impaired wound healing, which leads to the development of chronic non-healing wounds and ultimately amputation, is a major problem worldwide. Although recently endothelial progenitor cell-derived cell therapy has been used as a therapeutic intervention to treat diabetic wounds, thereby promoting neovascularization, the results, however, are not satisfactory. In this article, we have discussed the several steps that are involved in the neovascularization process, which might be impaired during diabetes...
March 7, 2017: Cellular Reprogramming
https://www.readbyqxmd.com/read/28259617/the-role-of-bone-marrow-aspirate-cells-in-the-management-of-atrophic-mandibular-fractures-by-mini-invasive-surgical-approach-single-institution-experience
#15
Giuditta Mannelli, Francesco Arcuri, Marco Conti, Tommaso Agostini, Mirco Raffaini, Giuseppe Spinelli
PURPOSE: The treatment of fractures involves addressing the biology of fracture repair and the mechanical stability of fracture fixation. Traditionally it has included the addition of bone graft to enhance healing. New advances in the understanding of the cellular and molecular mechanisms of fracture repair have led to the use of growth factors to accelerate bone healing. This study aimed to assess the advantages of autologous stem cell use for atrophic mandibular fracture treatment in comparison to standard technique...
January 12, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28255771/amniotic-membrane-in-ophthalmology-properties-preparation-storage-and-indications-for-grafting-a-review
#16
REVIEW
Katerina Jirsova, Gary L A Jones
The use of amniotic membrane in ophthalmic surgery and other surgical procedures in the fields of dermatology, plastic surgery, genitourinary medicine and otolaryngology is on the increase. Furthermore, amniotic membrane and its epithelial and mesenchymal cells have broad use in regenerative medicine and hold great promise in anticancer treatment. Amniotic membrane is a rich source of biologically active factors and as such, promotes healing and acts as an effective material for wound dressing. Amniotic membrane supports epithelialization and exhibits anti-fibrotic, anti-inflammatory, anti-angiogenic and anti-microbial features...
March 2, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28254468/pharmacologically-targeting-beta-catenin-for-nf1-associated-deficiencies-in-fracture-repair
#17
Gurpreet S Baht, Puviindran Nadesan, David Silkstone, Benjamin A Alman
Patients with Neurofibromatosis type 1 display delayed fracture healing and the increased deposition of fibrous tissue at the fracture site. Severe cases can lead to non-union and even congenital pseudarthrosis. Neurofibromatosis type 1 is caused by a mutation in the NF1 gene and mice lacking the Nf1 gene show a fracture repair phenotype similar to that seen in patients. Tissue from the fracture site of patients with Neurofibromatosis type 1 and from mice deficient in the Nf1 gene both show elevated levels of β-catenin protein and activation of β-catenin mediated signaling...
February 22, 2017: Bone
https://www.readbyqxmd.com/read/28252337/accelerated-wound-healing-with-combined-npwt-and-ipc-a-case-series
#18
Kristian Arvesen, Camilla Bak Nielsen, Karsten Fogh
Negative pressure wound therapy (NPWT) and intermittent pneumatic compression (IPC) have traditionally been used in patients with chronic complicated non-healing wounds. The aim of this study (retrospective case series) was to describe the use of NPWT in combination with IPC in patients with a relatively short history (2-6 months) of ulcers. All wounds showed improved healing during the treatment period with marked or moderate reduction in ulcer size, and granulation tissue formation was markedly stimulated...
March 2017: British Journal of Community Nursing
https://www.readbyqxmd.com/read/28245242/assessing-and-managing-wounds-of-buruli-ulcer-patients-at-the-primary-and-secondary-health-care-levels-in-ghana
#19
Naa Okaikor Addison, Stefanie Pfau, Eric Koka, Samuel Yaw Aboagye, Grace Kpeli, Gerd Pluschke, Dorothy Yeboah-Manu, Thomas Junghanss
BACKGROUND: Beyond Mycobacterium ulcerans-specific therapy, sound general wound management is required for successful management of Buruli ulcer (BU) patients which places them among the large and diverse group of patients in poor countries with a broken skin barrier. METHODS: Clinically BU suspicious patients were enrolled between October 2013 and August 2015 at a primary health care (PHC) center and a municipal hospital, secondary health care (SHC) center in Ghana...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28242666/adjuvant-antibiotic-activity-of-acidic-sophorolipids-with-potential-for-facilitating-wound-healing
#20
Helen L Lydon, Niki Baccile, Breedge Callaghan, Roger Marchant, Christopher A Mitchell, Ibrahim M Banat
The sophorolipid class of biosurfactants are finding increasing use in personal care as well as pharmaceutical products and have the potential to disrupt biofilm formation and inhibit growth in a variety of clinically relevant organisms. In order to investigate potential biomedical applications of sophorolipids derived from non-pathogenic organisms, we fractionated and purified glycolipid biosurfactant sophorolipids produced by the yeast Starmerella bombicola, which yielded both acidic C 18-1 acetylated and non-acetylated congeners that were essentially free from other contaminants (>95% purity)...
February 27, 2017: Antimicrobial Agents and Chemotherapy
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