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Non-healing wounds treatments

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https://www.readbyqxmd.com/read/28926892/-effect-and-mechanism-of-silibinin-on-the-inhibition-of-alk-positive-nsclc-cells-by-sensitizing-crizotinib
#1
C C Lin, C H Lu, Y H Pan, L Jiao, H Y Chen, L Li, Y He
Objective: To explore the synergistic effect of silibinin combined with crizotinib on anaplastic lymphoma kinase positive (ALK+ ) non-small cell lung cancer (NSCLC) cells and its mechanism. Methods: H2228 and H3122 cells were treated with silibinin, crizotinib alone or in combination. Cell proliferation was measured by 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay and colony formation assay. Migration or invasion ability was tested by wound healing assay or transwell assay, respectively...
September 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28912573/low-magnitude-high-frequency-vibration-accelerated-the-foot-wound-healing-of-n5-streptozotocin-induced-diabetic-rats-by-enhancing-glucose-transporter-4-and-blood-microcirculation
#2
Caroline Oi-Ling Yu, Kwok-Sui Leung, Jonney Lei Jiang, Tina Bai-Yan Wang, Simon Kwoon-Ho Chow, Wing-Hoi Cheung
Delayed wound healing is a Type 2 diabetes mellitus (DM) complication caused by hyperglycemia, systemic inflammation, and decreased blood microcirculation. Skeletal muscles are also affected by hyperglycemia, resulting in reduced blood flow and glucose uptake. Low Magnitude High Frequency Vibration (LMHFV) has been proven to be beneficial to muscle contractility and blood microcirculation. We hypothesized that LMHFV could accelerate the wound healing of n5-streptozotocin (n5-STZ)-induced DM rats by enhancing muscle activity and blood microcirculation...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28902422/transplantation-of-non-cultured-stromal-vascular-fraction-cells-of-adipose-tissue-ameliorates-osteonecrosis-of-the-jaw-like-lesions-in-mice
#3
Shinichiro Kuroshima, Muneteru Sasaki, Kazunori Nakajima, Saki Tamaki, Hiroki Hayano, Takashi Sawase
The precise pathoetiology and effective treatment strategies for bisphosphonate-related osteonecrosis of the jaw (BRONJ) remain unknown. Transplantation of non-cultured stromal vascular fraction (SVF) cells has been demonstrated to be a useful method for regenerative medicine in place of stem cell therapy. This study investigated the effects of non-cultured SVF transplantation on tooth extraction socket healing in mice. Both chemotherapeutic/bisphosphonate combination therapy for 7 weeks and tooth extraction of maxillary first molars at 3 weeks after drug administration were performed using female C57BL/6J mice...
September 13, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28898355/topical-cross-linked-ha-based-hydrogel-accelerates-closure-of-corneal-epithelial-defects-and-repair-of-stromal-ulceration-in-companion-animals
#4
David L Williams, Barbara M Wirostko, Glenwood Gum, Brenda K Mann
Purpose: The purpose of this study was to determine the safety of topical ocular administration of a cross-linked, modified hyaluronic acid (xCMHA-S) hydrogel, and its effectiveness in accelerating repair and closure of acute and nonhealing corneal ulcers in companion animals as a veterinary treatment and its utility as a model for therapy in human corneal ulceration. Methods: Two concentrations of xCMHA-S (0.33% and 0.75%) were topically administered to the eyes of rabbits six times daily for 28 days to assess safety...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28894635/topical-naltrexone-is-a-safe-and-effective-alternative-to-standard-treatment-of-diabetic-wounds
#5
Patricia J McLaughlin, Jarrett D Cain, Michelle B Titunick, Joseph W Sassani, Ian S Zagon
Objective: Diabetes affects more than 29 million individuals in the United States, resulting in healthcare costs approaching $245 billion. Approximately 15% of these individuals will develop a chronic, non-healing foot ulcer (diabetic foot ulcer [DFU]) that, if untreated, may lead to amputation. The current treatments for DFU are expensive, have significant side-effects, and often result in non-compliance. A new topical treatment is described that accelerates cutaneous wound repair and is disease modifying by targeting underlying aberrant diabetic pathways...
September 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28892596/peyronie-s-disease-watch-out-for-the-bend
#6
Christopher Love, Darren J Katz, Eric Chung, Ohad Shoshany
BACKGROUND: Peyronie's disease is a relatively common condition in urological practice, but is still poorly identified and understood in the wider medical community and by most of the public. Identifying the condition and appropriate referral for expert opinion can significantly lessen the physical and psychological effect on patients. OBJECTIVE: The objective of this article is to provide general practitioners with a concise and updated review of Peyronie's disease, with the aim of helping them to provide appropriate advice to their patients...
September 2017: Australian Family Physician
https://www.readbyqxmd.com/read/28890068/is-the-endovascular-treatment-of-mild-iliac-stenoses-worthwhile-to-improve-wound-healing-in-patients-undergoing-femoro-tibial-bypass
#7
Paolo Sapienza, Luigi Venturini, Raffaele Grande, Valerio Scarano Catanzaro, Sergio Gazzanelli, Antonio V Sterpetti, Elvira Tartaglia
OBJECTIVE: After an infrapopliteal reconstruction, minor amputations are frequently required, but even in the case of successful revascularization, wound healing is a major concern. We studied the role of iliac artery inflow correction in patients undergoing infrapopliteal vein grafts to improve the heal of midfoot amputation. METHODS: Thirty-eight patients affected with Rutherford Grade III Category 5 PAD, who underwent successful simultaneous iliac endovascular procedure, infrapopliteal reversed vein bypass graft, and minor amputation, were enrolled in this retrospective study...
September 7, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28887854/human-tissue-inhibitor-of-metalloproteinases-1-improved-wound-healing-in-diabetes-through-its-anti-apoptotic-effect
#8
Guojuan Lao, Meng Ren, Xiaoyi Wang, Jinglu Zhang, Yanrui Huang, Dan Liu, Hengcong Luo, Chuan Yang, Li Yan
Impaired wound healing accompanies severe cell apoptosis in diabetic patients. Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) was known to have effects on promoting growth and anti-apoptosis for cells. we aimed to determine the actual levels of TIMP-1 and cell apoptosis in: 1) the biopsies of diabetic and non-diabetic foot tissue; 2) the human fibroblasts with or without treatments of Advanced Glycation End Products (AGEs). Next, in both human fibroblasts and the animal model of diabetic rats, to determine the improved levels of cell apoptosis and wound healing after the treatments of either active protein of TIMP-1 or in vivo expression of gene therapy vector-mediated TIMP-1...
September 8, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28880053/liver-fibrosis-the-2017-state-of-art
#9
Gian P Caviglia, Chiara Rosso, Sharmila Fagoonee, Giorgio M Saracco, Rinaldo Pellicano
Liver fibrosis is a wound-healing response to a wide spectrum of chronic liver injuries. It is characterized by loss of hepatocytes and alteration in hepatic architecture following an imbalance between extracellular matrix synthesis and degradation. Irrespectively of underlying etiology, fibrosis may progress to cirrhosis and specific pathogenetic mechanisms as well as different disease patterns may be identified according to etiology. Liver biopsy is still considered the gold standard for fibrosis assessment, despite the fact that it is invasive, has poor patient compliance and is not exempt of complications...
September 5, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28879183/deep-sequencing-transcriptome-analysis-of-murine-wound-healing-effects-of-a-multicomponent-multitarget-natural-product-therapy-tr14
#10
Georges St Laurent, Bernd Seilheimer, Michael Tackett, Jianhua Zhou, Dmitry Shtokalo, Yuri Vyatkin, Maxim Ri, Ian Toma, Dan Jones, Timothy A McCaffrey
Wound healing involves an orchestrated response that engages multiple processes, such as hemostasis, cellular migration, extracellular matrix synthesis, and in particular, inflammation. Using a murine model of cutaneous wound repair, the transcriptome was mapped from 12 h to 8 days post-injury, and in response to a multicomponent, multi-target natural product, Tr14. Using single-molecule RNA sequencing (RNA-seq), there were clear temporal changes in known transcripts related to wound healing pathways, and additional novel transcripts of both coding and non-coding genes...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28863882/evaluation-of-mandibular-bone-after-dental-extraction-in-rats-treated-with-antiresorptive-drugs
#11
Victor Lousan Do Nascimento Poubel, Diogo Lenzi Capella, Adair Roberto Soares Santos, Márcio Correa, Letícia Ruhland Correa, Elena Riet Correa Rivero
PURPOSE: Zoledronic acid (ZOL) and denosumab (Dmab) are commonly used to treat bone pathologies. Because these drugs suppress bone metabolism, this study sought to compare their effect on bone repair after tooth extraction. MATERIALS AND METHODS: Four-week-old male Wistar rats were randomly assigned to 1 of 3 groups: ZOL 0.125 mg/kg, Dmab 0.25 mg/kg, or saline solution 10 mL/kg (control). After 1 week of treatment, the first left molar was extracted; the rats were euthanized at 28 days...
August 3, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28857457/non-adherence-to-treatment-of-chronic-wounds-patient-versus-professional-perspectives
#12
Christine Moffatt, Susie Murray, Vaughan Keeley, Aimee Aubeeluck
The reasons for the non-adherence to treatment for wound healing are complex and fall into unintentional and intentional categories. This study explored intentional and unintentional non-adherence to treatment from patient/carer and health care professional perspectives. Patients with wounds receiving ALLEVYN Life dressings (n = 20) and patients not receiving ALLEVYN Life dressings who were deemed to be non-adherent to treatment regimes (n = 6) took part in semi-structured interviews to explore their experiences of living with a wound, treatment and intentional and unintentional non-adherence...
August 30, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28853175/safety-of-non-ablative-fractional-laser-for-acne-scars-within-1-month-after-treatment-with-oral-isotretinoin-a-randomized-split-face-controlled-trial
#13
Sandeep S Saluja, Matthew L Walker, Erika M Summers, Payam Tristani-Firouzi, David R Smart
BACKGROUND AND OBJECTIVE: Based on reports of poor wound healing and scarring, it is currently recommended that patients wait 6 months after completion of oral isotretinoin therapy before the safe initiation of laser treatment. Our aim was to evaluate the safety of non-ablative fractional laser (NAFL) treatment for acne scars within 1 month after isotretinoin therapy. STUDY DESIGN/METHODS: This was a randomized split-face controlled trial involving 10 patients with acne scars who had completed isotretinoin treatment...
August 29, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28851894/activated-mesenchymal-stem-cells-interact-with-antibiotics-and-host-innate-immune-responses-to-control-chronic-bacterial-infections
#14
Valerie Johnson, Tracy Webb, Annalis Norman, Jonathan Coy, Jade Kurihara, Daniel Regan, Steven Dow
Chronic bacterial infections associated with biofilm formation are often difficult to resolve without extended courses of antibiotic therapy. Mesenchymal stem cells (MSC) exert antibacterial activity in vitro and in acute bacterial infection models, but their activity in chronic infection with biofilm models has not been previously investigated. Therefore, we studied the effects of MSC administration in mouse and dog models of chronic infections associated with biofilms. Mice with chronic Staphylococcus aureus implant infections were treated by i...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28842435/mesenchymal-stem-cells-correct-impaired-diabetic-wound-healing-by-decreasing-ecm-proteolysis
#15
Junwang Xu, Carlos Zgheib, Maggie Hodges, Robert C Caskey, Junyi Hu, Kenneth W Liechty
Impaired diabetic wound healing is associated with a dermal extracellular matrix protein profile favoring proteolysis; within the healing diabetic wound, this is represented by an increase in activated matrix metalloproteinase (MMPs). Treatment of diabetic wounds with mesenchymal stem cells (MSCs) has been shown to improve wound healing. Using in vitro models of fibroblast co-culture with MSCs and in vivo murine wound healing models, we tested the hypothesis that MSCs correct dysregulation of MMPs in a microRNA-29b dependent mechanism...
August 25, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/28842094/case-study-rare-case-of-mantle-cell-lymphoma-with-extranodal-involvement-in-the-foot
#16
Pauline Fu, Danielle Mercado, Vera Malezhik, Abul Ala Syed Rifat Mannan
Mantle cell lymphoma (MCL) is a rare type of non-Hodgkin lymphoma that commonly affects extranodal sites. The most commonly affected sites are the bone marrow, gastrointestinal tract, Waldeyer's ring, lung, and pleura. We report the case of an 80-year-old diabetic male, in MCL remission, who presented with a small dome-shaped nodule on his calf and an ipsilateral second digit non-healing ulceration after a traumatic fall. Despite surgical and conservative treatment, the wound worsened, resulting in histopathologic examination, which confirmed the presence of lymphocytes, indicating MCL relapse...
September 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28840372/persistent-perineal-sinus-after-abdominoperineal-resection
#17
Amélie Chau, Mathieu Prodeau, Hélène Sarter, Corinne Gower, Moshe Rogosnitzky, Yves Panis, Philippe Zerbib
BACKGROUND AND AIMS: Persistent perineal sinus (PPS) defined as a perineal wound remaining unhealed more than 6 months after abdominoperineal resection (APR) is a well-known complication. The aim of our study was (1) to evaluate the incidence of PPS after APR for Crohn's disease (CD) in the era of biotherapy, (2) to determine long-term outcome of PPS, (3) to study risk factors associated with delayed perineal healing, and (4) to compare the results in this CD patient group with patients without CD...
August 25, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28820322/platelet-rich-fibrin-prf-in-regeneration-of-intrabony-defects-a-randomized-controlled-trial
#18
Gauresh Kumar Patel, Sheela Kumar Gujjari, Veerendra Kumar S C
BACKGROUND AND OBJECTIVE: Platelet-rich fibrin (PRF) is a autologous non transfusional hemo-component with a high concentration of platelets. It incorporates leukocytes, platelets and growth factors within the dense fibrin matrix and can be used as healing biomaterial. This study assessed the adjunctive use of PRF in regenerative management of intrabony defects in comparison with open flap debridement. METHODOLOGY: 26 bilateral defects (13 per group) in 13 patients were randomized as either PRF (Test group) or Open flap debridement alone (control group) sites...
August 18, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28818631/topical-medical-cannabis-tmc-a-new-treatment-for-wound-pain-three-cases-of-pyoderma-gangrenosum
#19
Vincent Maida, Jason Corban
Pain associated with integumentary wounds is highly prevalent yet it remains an area of significant unmet need within healthcare. Currently, systemically administered opioids are the mainstay of treatment. However, recent publications are casting opioids in a negative light given their high side effect profile, inhibition of wound healing, and association with accidental overdose, incidents that are frequently fatal. Thus, novel analgesic strategies for wound-related pain need to be investigated. The ideal methods of pain relief for wound patients are modalities that are topical, lack systemic side effects, non-invasive, self-administered, and display rapid onset of analgesia...
August 14, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28818169/tuberculosis-of-open-cholecystectomy-wound
#20
Nauman Ahmed, Hammad Naeem Hammad Naeem Rana
Tuberculosis of the wound is a rare entity. A50-year lady presented with an "on and off discharging wound" from the postoperative wound site of open cholecystectomy, which was done 7 years ago. Patient did not respond to standard antibiotic treatment regimens; and also the culture remained equivocal during this period. We explored the wound and found a mass in subcutaneous tissue. Resection of mass was done and wound left open for closure by secondary intention. Histopathology of the resected mass revealed tuberculosis...
July 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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