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Non-healing wounds treatments

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https://www.readbyqxmd.com/read/30640578/diosgenin-exerts-its-tumor-suppressive-function-via-inhibition-of-cdc20-in-osteosarcoma-cells
#1
Cheng Long, Juan Chen, Hua Zhou, Tao Jiang, Xiang Fang, Dong Hou, Ping Liu, Hong Duan
Osteosarcoma (OS) is one of the aggressive malignancies for young adults. Cdc20 (cell division cycle 20 homologue) has been reported to exhibit an oncogenic role in OS, suggesting that inhibition of Cdc20 could be a novel strategy for the treatment of OS. Since Cdc20 inhibitors have side effects, it is important to discover the new CDC20 inhibitors with non-toxic nature. In the present study, we determine whether natural agent diosgenin is an inhibitor of Cdc20 in OS cells. We performed MTT, FACS, Wound healing assay, Transwell, Western blotting, transfection assays in our study...
January 14, 2019: Cell Cycle
https://www.readbyqxmd.com/read/30631095/application-of-autologous-platelet-rich-plasma-on-tooth-extraction-site-prevents-occurence-of-medication-related-osteonecrosis-of-the-jaws-in-rats
#2
Luan Felipe Toro, João Martins de Mello-Neto, Fernanda Furuse Ventura Dos Santos, Letícia Chaves Ferreira, Cristian Statkievicz, Luciano Tavares Ângelo Cintra, João Paulo Mardegan Issa, Rita Cássia Menegati Dornelles, Juliano Milanezi de Almeida, Maria José Hitomi Nagata, Valdir Gouveia Garcia, Leticia Helena Theodoro, Cláudio Aparecido Casatti, Edilson Ervolino
This study evaluated the effects of local application of autologous platelet-rich plasma (PRP) on the tooth extraction site of rats presenting the main risk factors for medication-related osteonecrosis of the jaw (MRONJ). For seven weeks, senile rats were submitted to systemic treatment with vehicle (VEH and VEH-PRP) or 100 μg/Kg of zoledronate (ZOL and ZOL-PRP) every three days. After three weeks, the first lower molar was extracted. VEH-PRP and ZOL-PRP received PRP at the tooth extraction site. Euthanasia was performed at 28 days postoperatively...
January 10, 2019: Scientific Reports
https://www.readbyqxmd.com/read/30627361/the-role-of-calcium-channel-blockers-in-wound-healing
#3
EDITORIAL
Hoda Mojiri-Forushani
Wound healing is a natural response to restore the injured tissue to normal. Wound healing is also complicated process involving different cellular, molecular and biochemical mechanisms and various types of cytokines and growth factors. Calcium channel blockers belong to cardiovascular medicine and administrated to treatment of hypertension, angina and cardiac arrhythmia because of vasodilatory effect. Calcium channel blockers is divided to dihydropyridine and non-dihydropyrine. The potential of both dihydropyridine and non-dihydropyrine calcium channel blockers in wound healing have been reported in different animal models and in vitro previously...
December 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/30626080/three-dimensional-stable-alginate-nanocellulose-gels-for-biomedical-applications-towards-tunable-mechanical-properties-and-cell-growing
#4
Priscila Siqueira, Éder Siqueira, Ana Elza de Lima, Gilberto Siqueira, Ana Delia Pinzón-Garcia, Ana Paula Lopes, Maria Esperanza Cortés Segura, Augusta Isaac, Fabiano Vargas Pereira, Vagner Roberto Botaro
Hydrogels have been studied as promising materials in different biomedical applications such as cell culture in tissue engineering or in wound healing. In this work, we synthesized different nanocellulose-alginate hydrogels containing cellulose nanocrystals, TEMPO-oxidized cellulose nanocrystals (CNCTs), cellulose nanofibers or TEMPO-oxidized cellulose nanofibers (CNFTs). The hydrogels were freeze-dried and named as gels. The nanocelluloses and the gels were characterized by different techniques such as Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and dynamic mechanical thermal analysis (DMTA), while the biological features were characterized by cytotoxicity and cell growth assays...
January 8, 2019: Nanomaterials
https://www.readbyqxmd.com/read/30611253/the-first-100-patients-treated-with-a-new-anatomical-pre-contoured-locking-plate-for-clavicular-midshaft-fractures
#5
Tania Reisch, Roland S Camenzind, Reto Fuhrer, Ulf Riede, Naeder Helmy
BACKGROUND: Pre-contoured locking plates were recently introduced in the management of clavicular midshaft fractures. These plates may offer advantages such as no necessity for intraoperative bending and reduced plate irritation. The purpose of this study was to review the clinical and radiographical outcome of the first 100 patients treated with a new anatomical pre-contoured locking plate. METHODS: In a retrospective single-center study, 100 consecutive patients (16 female, 84 male) with a median age of 40 years (range 15-82) who underwent surgery for clavicular midshaft fractures with a VariAx locking plate (Stryker Corporation Kalmazoo, MI, USA) between March 2012 and January 2016 were included...
January 5, 2019: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30607489/chitosan-and-its-derivatives-synthesis-biotechnological-applications-and-future-challenges
#6
REVIEW
Muhammad Shahid Riaz Rajoka, Liqing Zhao, Hafiza Mahreen Mehwish, Yiguang Wu, Shahid Mahmood
Chitosan is a naturally occurring biodegradable as well as a non-toxic polymer generated from chitin through alkaline deacetylation reaction, and it is insoluble in organic/inorganic solvents and water. Furthermore, chitosan is one of the most plentiful cationic polymers in natural surroundings. Due to its non-toxicity and biocompatibility, chitosan is extensively employed in industrial, biomedical, food, pharmaceutical, environmental, and agricultural industry. Chitosan-based biomaterials exhibit great potential in various biotechnological applications, such as anti-hypertensive therapy, anti-oxidant, anti-microbial, anti-allergic, immunostimulant, cancer therapy, delivery of genetic materials, delivery of bone morphogenetic type-2, wound healing, treatment of wastewater, hypocholesterolemic, and bio-imaging...
January 3, 2019: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/30607063/applications-of-propolis-in-dentistry-a-review
#7
REVIEW
Amir Jalal Abbasi, Farnoush Mohammadi, Mohamad Bayat, Shimelis Megersa Gema, Hannaneh Ghadirian, Hasti Seifi, Hananeh Bayat, Naghmeh Bahrami
Background: Propolis is a resinous substance obtained from the beehives that has antioxidant, anti-bacteria, anti-virus, anti-fungal, anti-tumor and anti-inflammatory activity. The aim of this study was to review the studies about the role of propolis in improving dental and oral health. Methods: This study reviewed the published articles regarding the applications of propolis in dentistry. An electronic search of the literature was carried out in Farsi electronic databases including Google, Medlib...
July 2018: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/30606527/chitosan-hydrogels-containing-nanoencapsulated-phenytoin-for-cutaneous-use-skin-permeation-penetration-and-efficacy-in-wound-healing
#8
Aline Marquez Cardoso, Edilene Gadelha de Oliveira, Karine Coradini, Franciele Aline Bruinsmann, Tanira Aguirre, Ricardo Lorenzoni, Raquel Cristiane Silva Barcelos, Karine Roversi, Domenika Rubert Rossato, Adriana Raffin Pohlmann, Sílvia Stanisçuaski Guterres, Marilise Escobar Burger, Ruy Carlos Ruver Beck
Although phenytoin is an antiepileptic drug used in the oral treatment of epilepsy, its off-label use as a cutaneous healing agent has been studied in recent years due to the frequent reports of gingival hyperplasia after oral administration. However, the cutaneous topical application of phenytoin should prevent percutaneous skin permeation. Therefore, the aim of this study was to evaluate the in vitro skin permeation/retention and in vivo effects of nanocapsules and nanoemulsions loaded with phenytoin and formulated as chitosan hydrogels on the healing process of cutaneous wounds in rats...
March 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30605737/advanced-drug-delivery-systems-and-artificial-skin-grafts-for-skin-wound-healing
#9
REVIEW
Hye Sung Kim, Xiaoyan Sun, Jung-Hwan Lee, Hae-Won Kim, Xiaobing Fu, Kam W Leong
Cutaneous injuries, especially chronic wounds, burns, and skin wound infection, require painstakingly long-term treatment with an immense financial burden to healthcare systems worldwide. However, clinical management of chronic wounds remains unsatisfactory in many cases. Various strategies including growth factor and gene delivery as well as cell therapy have been used to enhance the healing of non-healing wounds. Drug delivery systems across the nano, micro, and macroscales can extend half-life, improve bioavailability, optimize pharmacokinetics, and decrease dosing frequency of drugs and genes...
December 31, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/30605311/laser-activatable-cus-nanodots-to-treat-multidrug-resistant-bacteria-and-release-copper-ion-to-accelerate-wound-healing-for-infected-chronic-nonhealing-wounds
#10
Yue Qiao, Yuan Ping, Hongbo Zhang, Fengyong Liu, Bo Zhou, Yinhui Yu, Tingting Xie, Wanli Li, Danni Zhong, Yuezhou Zhang, Ke Yao, Hélder A Santos, Min Zhou
Chronic non-healing wounds have imposed serious challenges in the clinical practice, especially for the patients infected with multidrug-resistant (MDR) microbes. Herein, we developed an ultrasmall copper sulfide (covellite) nanodots (CuS NDs)-based dual functional nanosystem to cure multidrug-resistant bacteria-infected chronic non-healing wound. The nanosystem could eradicate multidrug-resistant bacteria and expedite wound healing simultaneously, owing to the photothermal effect and remote control of copper ion release...
January 3, 2019: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30604611/fibrin-nanoparticles-coupled-with-keratinocyte-growth-factor-enhance-dermal-wound-healing-rate
#11
Ismaeel Muhamed, Erin Sproul, Frances S Ligler, Ashley C Brown
Expediting the wound healing process is critical for patients chronically ill from non-healing wounds and diseases such as hemophilia or diabetes or who have suffered trauma including easily infected open wounds. FDA-approved external tissue sealants include the topical application of fibrin gels, which can be 500 times denser than natural fibrin clots. With lower clot porosity and higher polymerization rates than physiologically formed fibrin clots, the commercial gels quickly stop blood loss, but impede the later clot degradation kinetics and thus retard tissue-healing rates...
January 3, 2019: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30594943/lincrna-p21-mediates-the-anti-cancer-effect-of-ginkgo-biloba-extract-egb-761-by-stabilizing-e-cadherin-protein-in-colon-cancer
#12
Liqiang Chang, Tingting Liu, Zhongqiu Chai, Song Jie, Zhongyun Li, Meilian Liu, Wenhai Dong, Xixing Wang, Bing Zhou
BACKGROUND Ginkgo biloba extract EGb 761 is a putative antioxidant and has been used for thousands of years to treat a variety of ailments, including cancer. While it is known that cell behavior can be modulated by long non-coding RNAs (lncRNAs), the contributions of lncRNAs in EGb 761-induced anti-cancer effects are largely unknown. MATERIAL AND METHODS Colon cancer cell lines HT29 and HCT116 were used in this study. RT-qPCR was used to detect the relative expression of lincRNA-p21 in colon cancer cells. Wound-healing assay and Matrigel Transwell assay were performed to investigate the migration and invasion of colon cancer cells...
December 30, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30592957/-the-features-and-treatment-of-xixia-may-17th-explosion-accident
#13
Shuo Wang, Binghou Yang, Xiang Li, Yufei Sun, Shuguang Cao, Tianhua Zhu, Minjun Xu, Xueyin Li, Tianyu Li, Junxiang Zhao
OBJECTIVE: To retrospectively analyze the injury characteristics of victims and treatment strategies in the explosion accident on the 17th May 2018 in Xixia county (Xixia "May 17th" explosion accident). METHODS: Completion the Level Three treatment on time, which was depended on the leading role played by the regional trauma centers was the main rescuing mode of the work in Xixia county, where the primary and secondary treatments were the key parts. The three-level treatment model includes: the local hospital acts as a level-one emergency medical institution, county hospitals function as secondary emergency medical institutions, and other higher medical institutions are the tertiary first aid medical institutions...
December 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/30590494/potential-for-repurposing-the-personal-care-product-preservatives-bronopol-and-bronidox-as-broad-spectrum-antibiofilm-agents-for-topical-application
#14
Victoria E Lee, Alex J O'Neill
Objectives: Bacterial biofilms represent a major impediment to healing in chronic wounds and are largely refractory to the antibacterial agents currently used in wound management. From a repurposing screen of compounds considered safe for topical application in humans, we report the identification of the personal care product preservatives bronopol and bronidox as broad-spectrum antibiofilm agents and potential candidates for reducing biofilm burden in chronic wounds. Methods: Antibiofilm activity was assessed by viable counting against single-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa in the Calgary Biofilm Device, and against mixed-species biofilms of the two organisms growing on nitrocellulose discs...
December 22, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/30585053/-effects-of-human-adipose-derived-mesenchymal-stem-cells-and-platelet-rich-plasma-on-healing-of-wounds-with-full-thickness-skin-defects-in-mice
#15
X X Lei, P C Xu, L Zhang, M R Pang, J Tian, B Cheng
Objective: To investigate the effects of human adipose-derived mesenchymal stem cells (ADSCs) and platelet-rich plasma (PRP) on healing of wounds with full-thickness skin defects in mice. Methods: ADSCs were isolated from the lumbar and abdominal fat donated voluntarily by a healthy woman undergoing liposuction in the Department of Plastic Surgery of Guangzhou General Hospital of Guangzhou Military Area Command, and the cells were cultured and identified. ADSCs of the second passage were used in the following experiments...
December 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/30584899/the-role-of-lysophosphatidic-acid-in-the-physiology-and-pathology-of-the-skin
#16
REVIEW
Li Lei, Juan Su, Junchen Chen, Wangqing Chen, Xiang Chen, Cong Peng
Lysophosphatidic acid (LPA) is the simplest phospholipid found in nature. LPA is mainly biosynthesized in tissues and cells by autotoxin and PA-PLA1α/PA-PLA1β and is degraded by lipid phosphate phosphatases (LPPs). It is an important component of biofilm, an extracellular signal transmitter and intracellular second messenger. After targeting to endothelial differentiation gene (Edg) family LPA receptors (LPA1, LPA2, LPA3) and non-Edg family LPA receptors (LPA4, LPA5, LPA6), LPA mediates physiological and pathological processes such as embryonic development, angiogenesis, tumor progression, fibrogenesis, wound healing, ischemia/reperfusion injury, and inflammatory reactions...
December 22, 2018: Life Sciences
https://www.readbyqxmd.com/read/30583949/a-phase-ii-randomized-clinical-trial-for-the-treatment-of-recalcitrant-chronic-leg-ulcers-using-centrifuged-adipose-tissue-containing-progenitor-cells
#17
Ilaria Zollino, Diana Campioni, Maria Grazia Sibilla, Mirko Tessari, Anna Maria Malagoni, Paolo Zamboni
BACKGROUND AIMS: Preclinical and observational reports indicate that adipose tissue (AT) is a safe and promising tool to treat non-healing venous leg ulcers (VLUs). METHODS: From an initial cohort of 38 patients, 16 patients affected by non-healing VLUs were randomly allocated to the experimental arm (5 men and 3 women) and control arm (5 men and 3 women). In the experimental arm, wounds were treated by debridement, centrifuged adipose tissue (CAT), advanced dressings and compression...
December 21, 2018: Cytotherapy
https://www.readbyqxmd.com/read/30583219/type-i-collagen-peptides-and-nitric-oxide-releasing-electrospun-silk-fibroin-scaffold-a-multifunctional-approach-for-the-treatment-of-ischemic-chronic-wounds
#18
Satiesh Kumar Ramadass, Lone Saquib Nazir, Ramar Thangam, Ramesh Kannan Perumal, I Manjubala, Balaraman Madhan, Shanmuganathan Seetharaman
Biomimetic nanofibrous scaffolds targeting multiple dysfunctional processes provide a multi-pronged strategy to restore functions and regenerate the damaged tissue. This study investigates a strategy of combining a regenerative component, Type I collagen Peptide (CP), along with a nitric oxide donor, S-Nitrosoglutathione (GSNO), in the form of nanofibrous scaffold to address the non-healing diabetic ulcer. Silk Fibroin-Polyvinyl alcohol (SF-PVA) nanofibrous scaffold is used as a carrier for delivering functional moieties...
December 11, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30582339/allantoin-improves-histopathological-evaluations-in-a-rat-model-of-gastritis
#19
M Eslami-Farsani, A Moslehi, A Hatami-Shahmir
PURPOSE: Gastritis is found to be one of the most common gastrointestinal diseases worldwide. However, current therapeutic agents cause side effects, interaction, and recurrence. Allantoin has anti-inflammatory and wound healing properties. In this study, the therapeutic effect of allantoin has been assessed on the histopathological indices and gastric mucosal barrier of male rats. METHODS: Male rats were equally divided into control, ethanol-induced gastritis, and allantoin groups...
December 23, 2018: Physiology International
https://www.readbyqxmd.com/read/30578048/demonstration-of-the-safety-and-effectiveness-of-the-recell-%C3%A2-system-combined-with-split-thickness-meshed-autografts-for-the-reduction-of-donor-skin-to-treat-mixed-depth-burn-injuries
#20
J H Holmes, J A Molnar, J W Shupp, W L Hickerson, B T King, K N Foster, B A Cairns, J E Carter
INTRODUCTION: Split-thickness skin grafts (STSG) are the standard of care (SOC) for burns undergoing autografting but are associated with donor skin site morbidity and limited by the availability of uninjured skin. The RECELL® Autologous Skin Harvesting Device (RECELL® System, or RECELL) was developed for point-of-care preparation and application of a suspension of non-cultured, disaggregated, autologous skin cells, using 1cm2 of the patient's skin to treat up to 80cm2 of excised burn...
December 18, 2018: Burns: Journal of the International Society for Burn Injuries
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