keyword
https://read.qxmd.com/read/38497014/colorimetric-sensing-of-antioxidant-capacity-via-auric-acid-reduction-coupled-to-abts-oxidation
#21
JOURNAL ARTICLE
Burcu Bekdeşer, Reşat Apak
In this study, a simple and sensitive colorimetric assay has been developed for total antioxidant capacity measurement. The assay is based on the absorption measurement of the bluish-green oxidized product (ABTS·+ ) formed as a result of the oxidation reaction of the chromogenic reagent ABTS (2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) with gold(III). However, in the presence of antioxidants, the ABTS oxidation process is effectively suppressed due to the reduction of gold(III) ions to the zerovalent state forming gold nanoparticles (AuNPs)...
March 12, 2024: ACS Omega
https://read.qxmd.com/read/38495113/myofibroblasts-reside-in-the-middle-dermis-of-the-keloids-but-do-not-predict-the-response-to-injection-therapies-a-double-blinded-randomized-controlled-trial
#22
JOURNAL ARTICLE
Tuomas Komulainen, Patrik Daymond, Kristiina E Hietanen, Ilkka S Kaartinen, Tero A H Järvinen
INTRODUCTION: Keloids form as a pathological response to skin wound healing, and their etiopathology is poorly understood. Myofibroblasts, which are cells transformed from normal fibroblasts, are believed to contribute to pathological scar formation in wounds. METHODS: We carried out a double-blinded randomized controlled trial (RCT) comparing the efficacy of intralesional 5-fluorouracil (5-FU) and triamcinolone (TAC) injections in treating keloids. A total of 43 patients with 50 keloids were treated with either intralesional TAC or 5-FU injections, and their clinical response was evaluated...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38494243/uncovering-the-presence-of-cvpd-disease-in-citrus-varieties-of-south-sulawesi-indonesia-a-molecular-approach
#23
JOURNAL ARTICLE
Mustika Tuwo, Tutik Kuswinanti, Andi Nasruddin, Elis Tambaru
BACKGROUND: The citrus vein phloem degeneration (CVPD) disease is one of important diseases that infects citrus plants and threatens global citrus production and quality due to its severe symptoms and rapid spread. In the 2000s, South Sulawesi Province as one of the citrus producers in Indonesia reported CVPD infection. To date, it is still uncertain as to whether the citrus production center has already been rid of the CVPD infection, keeping in mind the low prevalence of certified citrus saplings use and sub-optimal management of plantations by farmers...
March 2024: Journal, Genetic Engineering & Biotechnology
https://read.qxmd.com/read/38490584/the-phase-of-tacs-entrained-pre-sma-beta-oscillations-modulates-motor-inhibition
#24
JOURNAL ARTICLE
Zhou Fang, Alexander T Sack, Inge Leunissen
Inhibitory control has been linked to beta oscillations in the fronto-basal ganglia network. Here we aim to investigate the functional role of the phase of this oscillatory beta rhythm for successful motor inhibition. We applied 20Hz transcranial alternating current stimulation (tACS) to the pre-supplementary motor area (pre-SMA) while presenting stop signals at 4 (Experiment 1) and 8 (Experiment 2) equidistant phases of the tACS entrained beta oscillations. Participants showed better inhibitory performance when stop signals were presented at the trough of the beta oscillation whereas their inhibitory control performance decreased with stop signals being presented at the oscillatory beta peak...
March 13, 2024: NeuroImage
https://read.qxmd.com/read/38489064/circulating-biomarkers-of-oxidative-stress-in-people-with-acne-vulgaris-a-systematic-review-and-meta-analysis
#25
JOURNAL ARTICLE
Liang Su, Fang Wang, Yuan Wang, Cheng Qin, Xuesong Yang, Jianzhou Ye
The relationship between acne vulgaris and oxidative stress biomarkers lacks a clear consensus. This study aimed to explore the potential correlation between acne vulgaris and circulating oxidative stress biomarkers (superoxide dismutase [SOD], malondialdehyde [MDA], and total antioxidant capacity [TAC]). We searched the PubMed, Embase, and Cochrane Library databases for articles published before June 26, 2023. The literature search combined free words and the medical subject headings terms related to acne vulgaris, SOD, MDA, and TAC...
March 15, 2024: Archives of Dermatological Research
https://read.qxmd.com/read/38486387/identification-of-genes-encoded-toxin-antitoxin-system-in-mycobacterium-tuberculosis-strains-from-clinical-sample
#26
JOURNAL ARTICLE
Karthikeyan Sundaram, Leela Kagithakara Vajravelu, Ravichandiran Velayutham, Utpal Mohan
BACKGROUND: The toxin-antitoxin system is a genetic element that is highly present in Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis. The toxin-antitoxin sys-tem comprises toxin protein and antitoxin protein or non-encoded RNA interacting with each other and inhibiting toxin activity. M. Tuberculosis has more classes of TA loci than non-tubercle bacilli and other microbes, including VapBC, HigBA, MazEF, ParDE, RelBE, MbcTA, PemIK, DarTG, MenTA, one tripartite type II TAC chaperone system, and hypothetical proteins...
March 14, 2024: Infectious Disorders Drug Targets
https://read.qxmd.com/read/38481237/effects-of-antioxidant-vitamins-a-d-e-and-trace-elements-cu-mn-se-zn-administration-on-gene-expression-metabolic-antioxidants-and-immunological-profiles-during-transition-period-in-dromedary-camels
#27
JOURNAL ARTICLE
Ahmed El-Sayed, Eman Ebissy, Ragab Mohamed, Ahmed Ateya
BACKGROUND: Nutrition has a primary role for optimum expression of genetic potential, and most of the farmers have limited resources of green fodder. Hence, a fat-soluble vitamin, especially vitamin A and E and trace elements remained most critical in the animal's ration and affects their productive and reproductive performance adversely. Animals cannot be able to produce these vitamins in their bodies; hence, an exogenous regular supply is needed to fulfil the physiological needs and to maintain high production performance...
March 13, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38476869/application-of-transcranial-alternating-current-stimulation-to-improve-esports-related-cognitive-performance
#28
JOURNAL ARTICLE
Fujia Jiao, Jie Zhuang, Michael A Nitsche, Zhenggen Lin, Yuanbo Ma, Yu Liu
INTRODUCTION: Electronic Sports (eSports) is a popular and still emerging sport. Multiplayer Online Battle Arena (MOBA) and First/Third Person Shooting Games (FPS/TPS) require excellent visual attention abilities. Visual attention involves specific frontal and parietal areas, and is associated with alpha coherence. Transcranial alternating current stimulation (tACS) is a principally suitable tool to improve cognitive functions by modulation of regional oscillatory cortical networks that alters regional and larger network connectivity...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38476648/brain-wide-activation-involved-in-15-ma-transcranial-alternating-current-stimulation-in-patients-with-first-episode-major-depressive-disorder
#29
JOURNAL ARTICLE
Jie Wang, Wenfeng Zhao, Huang Wang, Haixia Leng, Qing Xue, Mao Peng, Baoquan Min, Xiukun Jin, Liucen Tan, Keming Gao, Hongxing Wang
BACKGROUND: Although 15 mA transcranial alternating current stimulation (tACS) has a therapeutic effect on depression, the activations of brain structures in humans accounting for this tACS configuration remain largely unknown. AIMS: To investigate which intracranial brain structures are engaged in the tACS at 77.5 Hz and 15 mA, delivered via the forehead and the mastoid electrodes in the human brain. METHODS: Actual human head models were built using the magnetic resonance imagings of eight outpatient volunteers with drug-naïve, first-episode major depressive disorder and then used to perform the electric field distributions with SimNIBS software...
2024: General Psychiatry
https://read.qxmd.com/read/38476053/a-sunct-like-headache-associated-with-lateral-pontine-infarction-case-series-and-systematic-review
#30
Priabprat Jansem, Nattapat Watanapa, Sekh Thanprasertsuk, Wanakorn Rattanawong, Thanakit Pongpitakmetha, Prakit Anukoolwittaya
BACKGROUND AND AIM: Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and autonomic symptoms (SUNA) are trigeminal autonomic cephalalgias (TACs). The study explores the potential association between SUNCT/SUNA-like headaches and lateral pontine infarctions. METHODS: Case series and systematic review. RESULTS: We present three cases diagnosed with SUNCT following lateral pontine infarction on magnetic resonance imaging (MRI), along with a review of these cases and 10 others from the literature...
March 12, 2024: European Journal of Pain: EJP
https://read.qxmd.com/read/38475992/nuclear-ago2-promotes-myocardial-remodeling-by-activating-ankrd1-transcription-in-failing-hearts
#31
JOURNAL ARTICLE
Rong Xie, Shuai Yuan, Guo Hu, Jiabing Zhan, Kunying Jin, Yuyan Tang, Jiahui Fan, Yanru Zhao, Feng Wang, Chen Chen, Dao Wen Wang, Huaping Li
Heart failure (HF) is manifested by transcriptional and post-transcriptional reprogramming of critical genes. Multiple studies have revealed that microRNAs could translocate into subcellular organelles such as nucleus to modify gene expression. However, the functional property of subcellular Argonaute2 (AGO2), the core member of the microRNA machinery, has remained elusive in HF. AGO2 was found to be localized in both cytoplasm and nucleus of cardiomyocytes, and robustly increased in failing hearts of patients and animal models...
March 11, 2024: Molecular Therapy
https://read.qxmd.com/read/38472493/discussing-the-safety-and-effectiveness-of-transcatheter-arterial-embolization-combined-with-intravenous-chemotherapy-in-treating-locally-advanced-breast-cancer
#32
RANDOMIZED CONTROLLED TRIAL
Jingjun Zhang, Jie Zhang, Xiangke Niu, Yongxiang Zhou, Yufeng Guo, Yuanzhi Wang, Feng Shou
To investigate the efficacy and safety of drug-eluting bead-transarterial chemoembolization (DEB-TACE) combined with systemic chemotherapy in HR+/Her2- locally advanced breast cancer (LABC) patients. A controlled study was conducted on LABC patients treated at Jianyang People's Hospital and the First Affiliated Hospital of Chengdu Medical College from December 2020 to June 2022. The patients were randomly divided into the experimental group and the control group. The experimental group received DEB-TACE combined with the TAC regimen (175 mg/m2 paclitaxel-loaded albumin, 50 mg/m2 Doxorubicin, and 500 mg/m2 cyclophosphamide), while the control group received the TAC regimen intravenously...
March 12, 2024: Scientific Reports
https://read.qxmd.com/read/38468237/effects-of-intratesticular-injection-of-hypertonic-mannitol-and-saline-on-the-quality-of-donkey-sperm-indicators-of-oxidative-stress-and-testicular-tissue-pathology
#33
JOURNAL ARTICLE
Mohammadreza Baqerkhani, Ali Soleimanzadeh, Rahim Mohammadi
OBJECTIVES: The aim of the present study was to examine donkey sperm quality after intratesticular injection of hypertonic mannitol (HM) and saline (HS). METHODS: Randomly assigned to five treatment groups were 15 adult male donkeys: (1) Control group (no treatment), (2) Surgery group (surgical castration for testosterone control), (3) NS group (normal saline intratesticular injection), (4) HS group (hypertonic saline), and (5) HM group. We injected 20 mL per testicle...
March 11, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38466901/protective-effect-of-fkbp12-on-dextran-sulfate-sodium-induced-ulcerative-colitis-in-mice-as-a-tacrolimus-receptor
#34
JOURNAL ARTICLE
Birong Wang, Tingzan Li, Liqin Xu, Yuxi Cai
Ulcerative colitis (UC) is a multifactorial intestinal disease with a high incidence. In recent years, there has been an urgent need for pleiotropic drugs with a clear biosafety profile. Tacrolimus (TAC) is an immunosuppressant with stronger in vivo effects and better gastrointestinal absorption and is considered a potential treatment for UC. FKBP12 is a mediator of TAC immunosuppression; however, it is unclear whether it can participate in the development of UC in combination with TAC. The purpose of this study is to preliminarily validate the function of FKBP12 by establishing dextran sulfate sodium (DSS)-induced UC model and TAC treatment...
March 11, 2024: Nucleosides, Nucleotides & Nucleic Acids
https://read.qxmd.com/read/38460352/using-transcranial-alternating-current-stimulation-to-enhance-working-memory-skills-in-youths-with-22q11-2-deletion-syndrome-a-randomized-double-blind-sham-controlled-study
#35
JOURNAL ARTICLE
Caren Latrèche, Valentina Mancini, Vincent Rochas, Johanna Maeder, Lucia M Cantonas, Victor Férat, Maude Schneider, Christoph M Michel, Stephan Eliez
Abnormal cognitive development, particularly working memory (WM) deficits, is among the first apparent manifestations of psychosis. Yet, cognitive impairment only shows limited response to current pharmacological treatment. Alternative interventions to target cognition are highly needed in individuals at high risk for psychosis, like carriers of 22q11.2 deletion syndrome (22q11.2DS). Here we applied theta-tuned transcranial alternating current stimulation (tACS) between frontal and temporal regions during a visual WM task in 34 deletion carriers...
March 6, 2024: Psychiatry Research
https://read.qxmd.com/read/38460168/framework-nucleic-acids-based-vegf-signaling-activating-system-for-angiogenesis-a-dual-stimulation-strategy
#36
JOURNAL ARTICLE
Yichen Ge, Qingxuan Wang, Yangxue Yao, Qin Xin, Jiafei Sun, Wen Chen, Yunfeng Lin, Xiaoxiao Cai
Angiogenesis is crucial for tissue engineering, wound healing, and regenerative medicine. Nanomaterials constructed based on specific goals can be employed to activate endogenous growth factor-related signaling. In this study, based on the conventional single-stranded DNA self-assembly into tetrahedral framework nucleic acids (tFNAs), the Apt02 nucleic acid aptamer and dimethyloxallyl glycine (DMOG) small molecule are integrated into a complex via a template-based click chemistry reaction and toehold-mediated strand displacement reaction...
March 9, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38459869/bismuth-add-on-improves-the-efficacy-of-2-week-tegoprazan-based-triple-therapy-for-first-line-helicobacter-pylori-eradication-a-real-world-evidence-study
#37
JOURNAL ARTICLE
Jun-Hyung Cho
BACKGROUND: This study aimed to investigate the efficacy of bismuth added to a 2-week triple therapy consisting of tegoprazan (TPZ), amoxicillin, and clarithromycin for first-line Helicobacter pylori eradication. RESEARCH DESIGN AND METHODS: We reviewed the retrospective data of patients who received a 2-week TPZ-based triple therapy with or without 300 mg bismuth twice daily. The primary endpoint was the H. pylori eradication rate of adding bismuth to the TPZ-based triple regimen (TAC-B group), compared to no bismuth added (TAC group)...
March 9, 2024: Expert Review of Anti-infective Therapy
https://read.qxmd.com/read/38459095/doppler-ultrasonographic-scan-gene-expression-and-serum-profile-of-immune-apps-and-antioxidant-markers-in-egyptian-buffalo-cows-with-clinical-endometritis
#38
JOURNAL ARTICLE
Ahmed El-Sayed, Mohamed Refaai, Ahmed Ateya
The objective of this study was to elaborate Doppler ultrasonographic scan, genetic resistance and serum profile of markers associated with endometritis susceptibility in Egyptian buffalo-cows. The enrolled animals were designed as; twenty five apparently healthy buffalo-cows considered as a control group and twenty five infected buffalo with endometritis. There were significant (p < 0.05) increased of cervical diameter, endometrium thickness, uterine horn diameter, TAMEAN, TAMAX and blood flow through middle uterine artery with significant decrease of PI and RI values in endometritis buffalo-cows...
March 8, 2024: Scientific Reports
https://read.qxmd.com/read/38456854/clinical-effects-of-tacrolimus-blood-concentrations-early-after-allogeneic-hematopoietic-stem-cell-transplantation
#39
JOURNAL ARTICLE
Hiroyuki Kubo, Osamu Imataki, Tetsuya Fukumoto, Tomoya Ishida, Yukiko Hamasaki Kubo, Shunsuke Yoshida, Makiko Uemura, Haruyuki Fujita, Norimitsu Kadowaki
BACKGROUND AIMS: Tacrolimus (TAC) plus short-term methotrexate (stMTX) is used for graft-versus-host disease (GVHD) prophylaxis after allogeneic hematopoietic stem cell transplantation (allo-HSCT). TAC blood concentrations are frequently adjusted to enhance the graft-versus-leukemia/lymphoma effect or attenuate severe GVHD. Limited information is available on the clinical impact of these adjustments and the optimal time to perform them in order to achieve good clinical outcomes. METHODS: We retrospectively analyzed 211 patients who underwent allo-HSCT at our institutes...
March 5, 2024: Cytotherapy
https://read.qxmd.com/read/38456359/comparison-of-the-effectiveness-of-probiotic-supplementation-in-glucose-metabolism-lipid-profile-inflammation-and-oxidative-stress-in-pregnant-women
#40
JOURNAL ARTICLE
Yi-Ke Li, Chen-Lin Xiao, Huan Ren, Wen-Ru Li, Zhen Guo, Jian-Quan Luo
Objective : The optimal probiotic supplementation in pregnant women has not been thoroughly evaluated. By employing a network meta-analysis (NMA) approach, we compared the effectiveness of different probiotic supplementation strategies for pregnant women. Methods : A comprehensive search across multiple databases was performed to identify studies comparing the efficacy of probiotic supplements with each other or the control (placebo) among pregnant women. Results : This NMA, including 32 studies, systematically evaluated 6 probiotic supplement strategies: Lactobacillus , Lacticaseibacillus rhamnosus and Bifidobacterium (LRB), Lactobacillus acidophilus and Bifidobacterium (LABB), Lactobacillus acidophilus , Lacticaseibacillus casei , and Bifidobacterium bifidum (LLB), multi-combination of four probiotics (MP1), and multi-combination of six or more probiotics (MP2)...
March 8, 2024: Food & Function
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