Rong Xie, Shuai Yuan, Guo Hu, Jiabing Zhan, Kunying Jin, Yuyan Tang, Jiahui Fan, Yanru Zhao, Feng Wang, Chen Chen, Dao Wen Wang, Huaping Li
Heart failure (HF) is manifested by transcriptional and post-transcriptional reprogramming of critical genes. Multiple studies have revealed that microRNAs could translocate into subcellular organelles such as nucleus to modify gene expression. However, the functional property of subcellular Argonaute2 (AGO2), the core member of the microRNA machinery, has remained elusive in HF. AGO2 was found to be localized in both cytoplasm and nucleus of cardiomyocytes, and robustly increased in failing hearts of patients and animal models...
March 11, 2024: Molecular Therapy