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https://www.readbyqxmd.com/read/29339760/biochemical-and-genetic-characterization-of-a-novel-metallo-%C3%AE-lactamase-from-marine-bacterium-erythrobacter-litoralis-htcc-2594
#1
Xia-Wei Jiang, Hong Cheng, Ying-Yi Huo, Lin Xu, Yue-Hong Wu, Wen-Hong Liu, Fang-Fang Tao, Xin-Jie Cui, Bei-Wen Zheng
Metallo-β-lactamases (MBLs) are a group of enzymes that can inactivate most commonly used β-lactam-based antibiotics. Among MBLs, New Delhi metallo-β-lactamase-1 (NDM-1) constitutes an urgent threat to public health as evidenced by its success in rapidly disseminating worldwide since its first discovery. Here we report the biochemical and genetic characteristics of a novel MBL, ElBla2, from the marine bacterium Erythrobacter litoralis HTCC 2594. This enzyme has a higher amino acid sequence similarity to NDM-1 (56%) than any previously reported MBL...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29336873/optimization-of-novel-monobactams-with-activity-against-carbapenem-resistant-enterobacteriaceae-identification-of-lys228
#2
Folkert Reck, Alun Bermingham, Johanne Blais, Vladimir Capka, Taryn Cariaga, Anthony Casarez, Richard Colvin, Charles R Dean, Alex Fekete, Wanben Gong, Ellie Growcott, Hongqiu Guo, Adriana K Jones, Cindy Li, Fengxia Li, Xiaodong Lin, Mika Lindvall, Sara Lopez, David McKenney, Louis Metzger, Heinz E Moser, Ramadevi Prathapam, Dita Rasper, Patrick Rudewicz, Vijay Sethuraman, Xiaoyu Shen, Jacob Shaul, Robert L Simmons, Kyuto Tashiro, Dazhi Tang, Meiliana Tjandra, Nancy Turner, Tsuyoshi Uehara, Charles Vitt, Steven Whitebread, Aregahegn Yifru, Xu Zang, Qingming Zhu
Metallo-β-lactamases (MBLs), such as New Delhi metallo-β-lactamase (NDM-1) have spread world-wide and present a serious threat. Expression of MBLs confers resistance in Gram-negative bacteria to all classes of β-lactam antibiotics, with the exception of monobactams, which are intrinsically stable to MBLs. However, existing first generation monobactam drugs like aztreonam have limited clinical utility against MBL-expressing strains because they are impacted by serine β-lactamases (SBLs), which are often co-expressed in clinical isolates...
January 4, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29329255/peri-implant-behavior-of-sloped-shoulder-dental-implants-used-for-all-on-four-protocols-an-histomorphometric-analysis-in-dogs
#3
Jose Luis Calvo Guirado, Aldo Fabian Lucero-Sánchez, Ana Boquete Castro, Marcus Abboud, Sergio Gehrke, Manuel Fernández Dominguez, Rafael Arcesio Delgado Ruiz
The aim of this study was to evaluate the soft tissue thickness and marginal bone loss around dental implants with sloped micro-threaded shoulder (35° angle) in comparing with conventional design, inserted 35° degrees angulated in post extraction sockets and immediate loaded with temporary prosthesis simulating the all-on-four protocol. Materials and Methods: Six fox hound dogs received forty-eight post extraction dental implants with the same diameter and length (Medentika, Germany), but with different neck configurations...
January 12, 2018: Materials
https://www.readbyqxmd.com/read/29324516/implants-with-and-without-laser-microtextured-collar-a-10-year-clinical-and-radiographic-comparative-evaluation
#4
Renzo Guarnieri, Rolando Ceccarelli, John L Ricci, Tiziano Testori
INTRODUCTION: This article reports, after at least 10 years of follow-up, the comparative data of marginal bone loss (MBL) and periimplant soft tissue parameters, around implant with and without laser-microtextured (L) collar surface, previously reported at 3 years of follow-up. MATERIALS AND METHODS: Twenty implants with L collar surface (test) were placed adjacent to 20 control implants with machined (M) collar surface in 15 partially edentulous patients, who were followed up for at least 10 years as part of a prospective longitudinal study...
January 10, 2018: Implant Dentistry
https://www.readbyqxmd.com/read/29324290/ross-river-virus-envelope-glycans-contribute-to-disease-through-activation-of-the-host-complement-system
#5
Bronwyn M Gunn, Jennifer E Jones, Reed S Shabman, Alan C Whitmore, Sanjay Sarkar, Lance K Blevins, Thomas E Morrison, Mark T Heise
Mannose binding lectin (MBL) generally plays a protective role during viral infection, yet MBL-mediated complement activation promotes Ross River virus (RRV)-induced inflammatory tissue destruction, contributing to arthritis and myositis. As MBL binds to carbohydrates, we hypothesized that N-linked glycans on the RRV envelope glycoproteins act as ligands for MBL. Using a panel of RRV mutants lacking the envelope N-linked glycans, we found that MBL deposition onto infected cells was dependent on the E2 glycans...
January 8, 2018: Virology
https://www.readbyqxmd.com/read/29319510/metallo-beta-lactamase-producing-pseudomonas-aeruginosa-in-a-healthcare-setting-in-alexandria-egypt
#6
Amani F Abaza, Soraya A El Shazly, Heba S A Selim, Gehan S A Aly
Pseudomonas aeruginosa has emerged as a major healthcare associated pathogen that creates a serious public health disaster in both developing and developed countries. In this work we aimed at studying the occurrence of metallo-beta-lactamase (MBL) producing P. aeruginosa in a healthcare setting in Alexandria, Egypt. This cross sectional study included 1583 clinical samples that were collected from patients admitted to Alexandria University Students' Hospital. P. aeruginosa isolates were identified using standard microbiological methods and were tested for their antimicrobial susceptibility patterns using single disc diffusion method according to the Clinical and Laboratory Standards Institute recommendations...
September 27, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29316568/effect-of-submerged-vs-nonsubmerged-implant-placement-protocols-on-implant-failure-and-marginal-bone-loss-a-systematic-review-and-meta-analysis
#7
Ramy Moustafa Moustafa Ali, Ahmed Yaseen Alqutaibi, Amr Salah El-Din Gomaa, Mohamed Farouk Abdallah
PURPOSE: To compare prosthesis and implant failures and marginal bone loss (MBL) resulting from submerged vs nonsubmerged dental implant protocols. MATERIALS AND METHODS: Electronic and manual searches of two databases (MEDLINE [PubMed] and Cochrane) were conducted to identify randomized controlled trials (RCTs) comparing submerged to nonsubmerged dental implant protocols. Data were independently extracted by two reviewers, and meta-analyses were performed for the included RCTs...
January 2018: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29314753/functional-mannose-binding-lectin-levels-in-patients-with-pediatric-onset-systemic-lupus-erythematosus-in-remission
#8
Siyaram Didel, Deepti Suri, Amit Rawat, Surjit Singh
BACKGROUND: Complement system plays a crucial role in the pathogenesis of systemic lupus erythematosus (SLE). Excessive activation of complement causes tissue injury and SLE occurrence is typically associated with congenital deficiencies of the early components of the classical complement pathway. Mannose-binding lectin (MBL) is recognized as important causative factor in the etio-pathogenesis of SLE and MBL-2 gene has evolved as a candidate gene for SLE susceptibility. AIM: This study was done to assess the functional MBL (fMBL) level in SLE patients in remission and its co-relation with disease severity and outcome...
January 4, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29313133/influence-of-subcrestal-implant-placement-compared-with-equicrestal-position-on-the-peri-implant-hard-and-soft-tissues-around-platform-switched-implants-a-systematic-review-and-meta-analysis
#9
REVIEW
Cristina Valles, Xavier Rodríguez-Ciurana, Marco Clementini, Mariana Baglivo, Blanca Paniagua, Jose Nart
AIM: The aim of this article is to systematically review the effect of subcrestal implant placement compared with equicrestal position on hard and soft tissues around dental implants with platform switch. MATERIAL AND METHODS: A manual and electronic search (National Library of Medicine and Cochrane Central Register of Controlled Trials) was performed for animal and human studies published up to December 2016. Primary outcome variable was marginal bone level (MBL) and secondary outcomes were crestal bone level (CBL), soft tissue dimensions (barrier epithelium, connective tissue, and peri-implant mucosa), and changes in the position of soft tissue margin...
January 8, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29306566/bispecific-chimeric-antigen-receptors-targeting-the-cd4-binding-site-and-high-mannose-glycans-of-gp120-optimized-for-anti-human-immunodeficiency-virus-potency-and-breadth-with-minimal-immunogenicity
#10
Mustafa H Ghanem, Sara Bolivar-Wagers, Barna Dey, Agnes Hajduczki, Diego A Vargas-Inchaustegui, David T Danielson, Virgilio Bundoc, Li Liu, Edward A Berger
BACKGROUND AIMS: Chimeric antigen receptors (CARs) offer great potential toward a functional cure of human immunodeficiency virus (HIV) infection. To achieve the necessary long-term virus suppression, we believe that CARs must be designed for optimal potency and anti-HIV specificity, and also for minimal probability of virus escape and CAR immunogenicity. CARs containing antibody-based motifs are problematic in the latter regard due to epitope mutation and anti-idiotypic immune responses against the variable regions...
January 3, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29303020/risk-factors-outcomes-and-genotypes-of-carbapenem-nonsusceptible-klebsiella-pneumoniae-bloodstream-infection-a-three-year-retrospective-study-in-a-large-tertiary-hospital-in-northern-china
#11
Si-Han Zheng, Sheng-Ji Cao, Hui Xu, Dan Feng, Li-Ping Wan, Guang-Jie Wang, Xiao-Guang Xiao
OBJECTIVE: To investigate the independent risk factors, outcomes and genotypes associated with carbapenem-non-susceptible K. pneumoniae bloodstream infections (BSIs) in northern China from 2014 to 2016. METHODS: Over a three-year period, a total of 289 K. pneumoniae BSI patients were identified. Medical records were extracted to obtain the clinical information. Polymerase chain reactions (PCRs) were performed to analyse the multilocus sequence typing (MLST) types, Klebsiella pneumoniae carbapenemase (KPC) and metallo-β-lactamases (MBL) genes, for replicon typing of the 10 randomly selected carbapenem-non-susceptible K...
January 5, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29298876/correlation-between-mbl-cd14-and-tnf-%C3%AE-gene-polymorphisms-with-susceptibility-to-spinal-tuberculosis-in-chinese-population
#12
Mingfeng Zheng, Shiyuan Shi, Wei Wei, Qi Zheng, Yifan Wang, Xiaozhang Ying, Di Lu
Objective: This study investigated the clinical significances of mannose-binding lectin2(MBL2), cluster of differentiation 14(CD14) and tumor necrosis factor- α (TNF-α) gene polymorphisms in spinal tuberculosis(TB) patients in Chinese population. Methods: A total of 240 patients with spinal TB were enrolled in this study from May 2013 to August 2016 at Hangzhou Red Cross Hospital. 150 age- and sex-matched healthy subjectes were enrolled as controls. The genomic DNA was extracted from peripheral blood of all subjects, and the MBL2, CD14 and TNF-α gene polymorphisms were detected by direct DNA sequencing...
January 3, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29296273/new-delhi-metallo-%C3%AE-lactamase-1-producing-klebsiella-pneumoniae-isolates-in-hospitalized-patients-in-kashan-iran
#13
Farzaneh Firoozeh, Zeinab Mahluji, Ehsaneh Shams, Ahmad Khorshidi, Mohammad Zibaei
Background and Objectives: New Delhi metallo-ß-lactamase (NDM) is a newly emerging metallo-ß-lactamases, which can destroy all β-lactams including carbapenems. Therefore, this study aimed at evaluating New Delhi metallo-ß-lactamase-1-production in clinical isolates of Klebsiella pneumoniae in Kashan, Iran. Materials and Methods: In a cross-sectional study, 181 K. pneumoniae isolates were collected from clinical samples of patients, who referred to Shahid Beheshi hospital in Kashan during November 2013 and October 2014...
October 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29286750/complete-many-body-localization-in-the-t-j-model-caused-by-a-random-magnetic-field
#14
Gal Lemut, Marcin Mierzejewski, Janez Bonča
The many body localization (MBL) of spin-1/2 fermions poses a challenging problem. It is known that the disorder in the charge sector may be insufficient to cause full MBL. Here, we study dynamics of a single hole in one dimensional t-J model subject to a random magnetic field. We show that strong disorder that couples only to the spin sector localizes both spin and charge degrees of freedom. Charge localization is confirmed also for a finite concentration of holes. While we cannot precisely pinpoint the threshold disorder, we conjecture that there are two distinct transitions...
December 15, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29285477/pseudomonas-aeruginosa-producing-metallo-%C3%AE-lactamases-vim-imp-sme-and-aim-in-the-clinical-isolates-of-intensive-care-units-a-university-hospital-in-isfahan-iran
#15
Farzin Khorvash, Mohammadreza Yazdani, Shiva Shabani, Aliasghar Soudi
Background: Pseudomonas aeruginosa is a severe challenge for antimicrobial therapy, due to the chromosomal mutations or exhibition of intrinsic resistance to various antimicrobial agents such as most β-lactams. We undertook this study to evaluate the existence of SME, IMP, AIM, and VIM metallo-β-lactamases (MBL) encoding genes among P. aeruginosa strains isolated from Intensive Care Unit (ICU) patients in Al-Zahra Hospital in Isfahan, Iran. Materials and Methods: In a retrospective cross-sectional study that was conducted between March 2012 and April 2013, a total of 48 strains of P...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29273833/prospective-observational-study-on-the-association-between-serum-mannose-binding-lectin-levels-and-severe-outcome-in-critically-ill-patients-with-pandemic-influenza-type-a-h1n1-infection
#16
Elie Zogheib, Remy Nyga, Marjorie Cornu, Boualem Sendid, Julien Monconduit, Vincent Jounieaux, Julien Maizel, Christine Segard, Taïeb Chouaki, Hervé Dupont
BACKGROUND: Mannose-binding lectin (MBL) plays an important role in the innate immune response. In addition to activating the complement, MBL can induce cytokine production and contribute to a deleterious inflammatory response with severe A(H1N1)pdm09 virus infection. Our aim was to determine if serum MBL levels correlate with the risk of mortality in intensive care units (ICU) patients with A(H1N1)pdm09 infection. METHODS: Prospective observational study was performed in ICU patients with acute respiratory distress syndrome due to influenza A(H1N1)pdm09 virus...
December 22, 2017: Lung
https://www.readbyqxmd.com/read/29250863/cyclobutanone-mimics-of-intermediates-in-metallo-%C3%AE-lactamase-catalysis
#17
Martine I Abboud, Magda Kosmopoulou, Anthony Krismanich, Jarrod W Johnson, Philip Hinchliffe, Jürgen Brem, Timothy D W Claridge, James Spencer, Christopher Schofield, Gary I Dmitrienko
The most important resistance mechanism to β-lactam antibiotics involves hydrolysis by two β-lactamase categories: the nucleophilic serine (SBL) and the metallo- (MBL) β-lactamases. Cyclobutanones are hydrolytically stable β-lactam analogues with potential to inhibit both SBLs and MBLs. We describe solution and crystallographic studies on the interaction of a cyclobutanone penem analogue with the clinically important MBL SPM-1. NMR experiments using 19F-labeled SPM-1 imply the cyclobutanone binds to SPM-1 with micromolar affinity...
December 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29248513/detection-of-vim-1-and-imp-1-genes-in-klebsiella-pneumoniae-and-relationship-with-biofilm-formation
#18
Rohollah Khodadadian, Hossein Ali Rahdar, Ali Javadi, Mahmod Safari, Ahmad Khorshidi
Klebsiella pneumoniae is an important human pathogen that is considered in recent years due to nosocomial infections resistant to treatmentas well as the ability to form biofilms particularly in patients with urinary tract infection in ICU or hospital. The aim of this study was to evaluate the prevalence of VIM1, IMP1 genes and their ability to form biofilm in K. pneumoniae strains isolated from patients with urinary tract infection. In the study, using culture and biochemical methods, 1807 K. pneumoniae samples were isolated from patients with urinary tract infection hospitalized or referred to hospitals in Qom in 2013-2014...
December 14, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29248295/nota-analogue-a-first-dithiocarbamate-inhibitor-of-metallo-%C3%AE-lactamases
#19
En Zhang, Ming-Ming Wang, Shu-Chao Huang, Shuai-Min Xu, De-Yun Cui, Yuan-Li Bo, Peng-Yan Bai, Yong-Gang Hua, Chun-Ling Xiao, Shangshang Qin
The emergence of antibiotic drug (like carbapenem) resistance is being a global crisis. Among those resistance factors of the β-lactam antibiotics, the metallo-β-lactamases (MBLs) is one of the most important reasons. In this paper, a series of cyclic dithiocarbamate compounds were synthesized and their inhibition activities against MBLs were initially tested combined with meropenem (MEM) by in vitro antibacterial efficacy tests. Sodium 1,4,7-triazonane-1,4,7-tris(carboxylodithioate) (compound 5) was identified as the most active molecule to restore the activity of MEM...
November 7, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29243685/the-efficacy-of-short-6-mm-dental-implants-with-a-novel-thread-design
#20
Soheil Bechara, Tatjana Nimčenko, Ričardas Kubilius
OBJECTIVE: To assess efficacy of short (6 mm) implants with a novel macrostructure and thread design placed in a compromised bone situations of edentulous posterior regions of maxilla (3-4 mm of bone height under sinus floor) as compared to results of clinical situations treated with simultaneous maxillary sinus grafting and placement of long (≥10 mm) implants of the same company. STUDY DESIGN: Clinical cases of conducted clinical study. PATIENTS AND METHODS: Patients with compromised bone height in edentulous posterior regions of maxilla were randomly divided into two groups...
2017: Stomatologija
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