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Julia Smedbråten, Geir Mjøen, Anders Hartmann, Anders Åsberg, Halvor Rollag, Tom Eirik Mollnes, Leiv Sandvik, Morten W Fagerland, Steffen Thiel, Solbjørg Sagedal
BACKGROUND: Higher incidence of malignancy and infectious diseases in kidney transplant recipients is related to immunosuppressive treatment after transplantation and the recipient's native immune system. The complement system is an essential component of the innate immunity. The aim of the present study was to investigate the association of effector molecules of the lectin complement pathway with graft and patient survival after kidney transplantation. METHODS: Two mannan-binding lectin (MBL) associated proteases, MASP-2 and MASP-3 (activators of the lectin pathway) and two MBL-associated proteins, MAp44 and MAp19 (inhibitors of the lectin pathway) were measured at the time of transplantation in 382 patients (≥17 years old) transplanted in 2000-2001...
October 18, 2016: BMC Nephrology
Laura Pöyhönen, Liisa Kröger, Heini Huhtala, Johanna Mäkinen, Kirsi Nuolivirta, Jussi Mertsola, Qiushui He, Matti Korppi
BACKGROUND: Interferon-gamma (IFN-γ) is a key cytokine in defense against mycobacteria, including Bacillus Calmette-Guérin (BCG). Mannose-binding lectin (MBL) and Toll-like receptors (TLRs) are pattern-recognizing molecules of innate immunity. The aim of the present study was to investigate the relationship between polymorphisms in MBL, TLR1, TLR2, and TLR6 encoding genes and stimulated IFN-γ and interleukin-12 (IL-12) ex vivo production in BCG osteitis survivors. METHODS: Data on single nucleotide polymorphisms (SNPs) in the MBL2 gene and TLR1, TLR2, and TLR6 genes were available from 132 former BCG osteitis patients, and data on ex vivo IFN-γ and IL-12 production were available from 115 and 118 patients, respectively...
October 17, 2016: Pediatric Infectious Disease Journal
Rong-Qiang He, Zheng-Yu Weng
Many-body localization (MBL) is currently a hot issue of interacting systems, in which quantum mechanics overcomes thermalization of statistical mechanics. Like Anderson localization of non-interacting electrons, disorders are usually crucial in engineering the quantum interference in MBL. For translation invariant systems, however, the breakdown of eigenstate thermalization hypothesis due to a pure many-body quantum effect is still unclear. Here we demonstrate a possible MBL phenomenon without disorder, which emerges in a lightly doped Hubbard model with very strong interaction...
October 18, 2016: Scientific Reports
Tomasz Wołkowicz, Jan Andrzej Patzer, Wanda Kamińska, Rafał Gierczyński, Danuta Dzierżanowska
This study aimed to analyse the distribution of carbapenem resistance mechanisms among Pseudomonas aeruginosa clinical isolates. Fifty-five P. aeruginosa isolates, resistant both to imipenem and meropenem, from children hospitalised in 2009-2010 were studied. All strains were genotyped by pulsed-field gel electrophoresis (PFGE). Mutations in the oprD gene and the occurrence of insertion sequences (ISs) were determined by DNA sequencing. Mex efflux systems were determined by analysis using the efflux pump inhibitor Phe-Arg β-naphthylamide...
October 8, 2016: Journal of Global Antimicrobial Resistance
José Ramón Corcuera-Flores, Julián López-Giménez, Julián López-Jiménez, Ana López-Giménez, Javier Silvestre-Rangil, Guillermo Machuca-Portillo
OBJECTIVES: To evaluate implant survival rate and marginal bone loss (MBL) after 4 years in patients with Down syndrome and cerebral palsy, compared with a healthy control group. MATERIAL AND METHODS: The case group comprises 102 implants in 19 patients (71 cerebral palsy, 21 Down syndrome), and the control group comprises 70 implants in 22 healthy patients. One implant per patient was selected (n = 41 implants) to take clustering effects into account. MBL was measured using two panoramic radiographs (after surgery and 4 years later)...
October 14, 2016: Clinical Oral Investigations
A Guzek, Krzysztof Korzeniewski, D Tomaszewski, Z Rybicki, E Zwolińska
The article presents the results of 11-year study (2005-2015) of Gram-negative bacteria responsible for pneumonia in 2033 mechanically ventilated patients hospitalized in Intensive Care Unit. Of 8796 biological samples, consisting mainly of bronchial aspirate (97.9 %), 2056 bacterial strains were isolated and subjected to identification. VITEK 2 was used to determine drug susceptibility (classified according to the EUCAST criteria). ESBL, MBL and KPC-producing strains were identified by means of phenotypic methods using appropriate discs...
October 14, 2016: Advances in Experimental Medicine and Biology
Laura Llull, Steffen Thiel, Sergio Amaro, Álvaro Cervera, Anna M Planas, Ángel Chamorro
Activation of the inflammatory generating complement system might play a pathogenic role in spontaneous subarachnoid hemorrhage (SAH). We studied whether plasma and cerebrospinal fluid (CSF) levels of complement proteins were associated with angiographic vasospasm and cerebral ischemic lesions after SAH. Ficolin-1 (M-ficolin), ficolin-3 (H-ficolin), mannose-binding lectin (MBL), MBL-associated serine protease 2 (MASP-2), MASP-3, and MAp44 were analyzed in plasma of 45 SAH patients at 24 h after bleeding. Additionally, ficolin-1 levels were measured in cerebrospinal fluid (CSF) samples obtained 24 h after bleeding in 19 patients with external ventricular drainage placement...
October 12, 2016: Molecular Neurobiology
M Adamiak, A Abdelbaset-Ismail, M Suszynska, A Abdel-Latif, J Ratajczak, M Z Ratajczak
Leukemia accepted article preview online, 13 October 2016. doi:10.1038/leu.2016.278.
October 13, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Xiaoyan Tang, Miao Hong, Laura Falivene, Lucia Caporaso, Luigi Cavallo, Eugene Y-X Chen
α-Methylene-γ-butyrolactone (MBL), a naturally occurring and biomass-sourced bifunctional monomer, contains both a highly reactive exocyclic C=C bond and a highly stable five-membered γ-butyrolactone ring. Thus, all previous work led to exclusive vinyl-addition polymerization (VAP) product P(MBL)VAP. Now, this work reverses this conventional chemoselectivity to enable the first ring-opening polymerization (ROP) of MBL, thereby producing exclusively unsaturated polyester P(MBL)ROP with Mn up to 21.0 kg/mol...
October 4, 2016: Journal of the American Chemical Society
Mansour Al-Askar, Tariq Abduljabbar, Fahim Vohra, Sandeep Pasumarthy, Elham Gholamiazizi, Michael Yunker, Georgios E Romanos, Fawad Javed
OBJECTIVE: There are no studies that have (a) compared self-perceived oral symptoms and clinical and radiographic periodontal parameters (plaque index [PI], bleeding on probing [BoP], clinical attachment loss [CAL], and marginal bone loss [MBL]) among shamma-chewers (SC) and gutka-chewers (GC); and (b) assessed periodontal parameters among SC. The aim of the present study was to compare the self-perceived oral symptoms and periodontal parameters among SC, GC, and controls. METHOD AND MATERIALS: Information regarding demographic characteristics and self-perceived oral symptoms was gathered using a structured questionnaire...
September 26, 2016: Quintessence International
Pierre-Olivier Delpech, Raphael Thuillier, Thibault SaintYves, Jerome Danion, Sylvain Le Pape, Edwin S van Amersfoort, Beatrijs Oortwijn, Gilles Blancho, Thierry Hauet
BACKGROUND: Ischemia reperfusion injury (IRI) induced immune response is a critical issue in transplantation. Complement and contact system activation are among its key mechanisms. STUDY DESIGN: We investigated the benefits of pre-reperfusion treatment with recombinant human C1INH (rhC1INH), inhibitor of both complement and contact activation, in a pig model of kidney autotransplantation, subjecting the organ to 60 min warm ischemia prior to 24 h static preservation to maximize damage...
2016: Journal of Translational Medicine
Wenzhi Niu, Penglai Wang, Shaoyue Zhu, Zongxiang Liu, Ping Ji
STATEMENT OF PROBLEM: Whether microthreads in the crestal portion can reduce the amount of marginal bone loss (MBL) around implants has not yet been determined. PURPOSE: The purpose of this systematic review was to investigate the marginal bone loss around dental implants with and without microthreads in the neck. MATERIAL AND METHODS: This review was based on the PRISMA guidelines. An electronic search with no restrictions on language was performed from inception to August 19, 2015, in PubMed, Cochrane Central Register of Controlled Trials, EMBASE, Web of Sciences, and AMED (Ovid) databases...
September 16, 2016: Journal of Prosthetic Dentistry
Tomomi Tani, Michael Shribak, Rudolf Oldenbourg
In 1948, Shinya Inoué arrived in the United States for graduate studies at Princeton. A year later he came to Woods Hole, starting a long tradition of summer research at the Marine Biological Laboratory (MBL), which quickly became Inoué's scientific home. Primed by his Japanese mentor, Katsuma Dan, Inoué followed Dan's mantra to work with healthy, living cells, on a fundamental problem (mitosis), with a unique tool set that he refined for precise and quantitative observations (polarized light microscopy), and a fresh and brilliant mind that was unafraid of challenging current dogma...
August 2016: Biological Bulletin
Diana Karpman, Ramesh Tati
Complement is activated during Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS). There is evidence of complement activation via the alternative pathway in STEC-HUS patients as well as from in vivo and in vitro models. Ozaki et al. demonstrate activation of the mannose-binding lectin (MBL) pathway in Shiga toxin-treated mice expressing human MBL2, but lacking murine Mbls. Treatment with anti-human MBL2 antibody was protective, suggesting that MBL pathway activation also contributes to Shiga toxin-mediated renal injury...
October 2016: Kidney International
Agurne Uribarri, Eneritz Bilbao, Xabier Marichalar-Mendia, Rafael Martínez-Conde, José M Aguirre, Fernando Verdugo
BACKGROUND: Susceptible individuals may be more prone to bone loss after augmentation procedures. PURPOSE: Identify plausible clinical and biological factors influencing apical and marginal bone remodeling at implants placed in augmented sinuses, in patients with and without history of periodontitis. MATERIALS AND METHODS: This prospective cross-sectional clinical study analyzed implant bone levels in a group of 104 patients with and without history of periodontitis undergoing 139 sinus augmentation procedures...
September 15, 2016: Clinical Implant Dentistry and related Research
Silvio Mario Meloni, Marco Tallarico, Milena Pisano, Erta Xhanari, Luigi Canullo
BACKGROUND: High primary implant stability is considered one of the main factors necessary for achieving predictable treatment outcomes with immediately loaded implant-supported screw-retained fixed complete denture prosthesis (FCDP). PURPOSE: To evaluate the 5-year clinical and radiographic outcomes of immediately loaded implants placed in edentulous patients using computer-assisted template-guided surgery to support a FCDP. MATERIALS & METHODS: Patients in need to be restored with a FCDP in the mandible or maxilla were included in this prospective study/ and treated using computer-assisted template-guided surgery...
September 15, 2016: Clinical Implant Dentistry and related Research
Mariana Nunes, Ricardo Faria Almeida, Antonio Campos Felino, Paulo Malo, Miguel de Araújo Nobre
PURPOSE: There is a need for more studies evaluating the marginal bone loss (MBL) of rehabilitations in the posterior regions of extremely resorbed maxillae and mandibles supported by short-length dental implants with a high crown/implant ratio (C/I-R). The aim of this study was to evaluate the influence of the C/I-R in implants on MBL considering dental implants with 4 mm of width and 7 mm of length. MATERIALS AND METHODS: This retrospective cohort study included 59 patients (mean age of 52...
September 2016: International Journal of Oral & Maxillofacial Implants
Tae-Gwan Eom, Hyo-Won Kim, Gyeo-Rok Jeon, Mi-Jung Yun, Jung-Bo Huh, Chang-Mo Jeong
PURPOSE: The purpose of this study was to investigate the influence of implant and drill diameters on the stability of implant and bone response. MATERIALS AND METHODS: An implant (GS II, Osstem Implant) with a 3.5-mm diameter and drills with three different diameters, differentiating the volume of bone compacted by the implant, were used in this study. Measurement of the insertion torque and observation of bone compression patterns were done during implant site preparation in minipigs...
September 2016: International Journal of Oral & Maxillofacial Implants
M Saidi, N Sadeghifard, H Kazemian, Z Sekawi, B Badakhsh, S Friadian, S Ghafourian
Herbal medicines are defined as traditionally used natural products. The current study in an attempt try to investigate the antibacterial activity on extended spectrum beta-lactamases (ESBL), methalo beta-lactamases (MBL) producing gram negative bacteria and methicillin resistant Staphylococcus aureus (MRSA) and subsequently, to determine the antioxidant activity of Thymus daenensis. For this reasons, firstly cytotoxicity of T. daenensis was determined by MTT assay. Then, essential oil was subjected for antibacterial and antioxidant activity...
September 14, 2016: Drug Research
S Pieralli, R J Kohal, R E Jung, K Vach, B C Spies
To determine the survival rate and marginal bone loss (MBL) of zirconia dental implants restored with single crowns or fixed dental prostheses. An electronic search was conducted up to November 2015 (without any restriction regarding the publication time) through the databases MEDLINE (PubMed), Cochrane Library, and EMBASE to identify randomized controlled clinical trials and prospective clinical trials including >15 patients. Primary outcomes were survival rate and MBL. Furthermore, the influence of several covariates on MBL was evaluated...
September 13, 2016: Journal of Dental Research
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