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https://www.readbyqxmd.com/read/27922548/methylcobalamin-prevents-mutant-superoxide-dismutase-1-induced-motor-neuron-death-in-vitro
#1
Shunsuke Ito, Yukina Izumi, Tetsuhiro Niidome, Yuichi Ono
Amyotrophic lateral sclerosis (ALS) is an incurable progressive neurodegenerative disorder that causes motor dysfunction. Treatments and drugs that slow progression of ALS have garnered great interest. In the present study, we show that the vitamin B12 analog methylcobalamin (MBL) effectively and dose dependently prevented embryonic stem cell-derived motor neuron death induced by cocultivation with astrocytes expressing mutant human superoxide dismutase-1 (G93A). Moreover, cotreatment of MBL with a conventional ALS drug, riluzole, further enhanced survival of motor neurons in this in-vitro ALS model...
December 2, 2016: Neuroreport
https://www.readbyqxmd.com/read/27915986/molecular-analysis-of-pseudomonas-aeruginosa-metallo-beta-lactamase-a-first-report-of-an-iranian-referral-pediatric-hospital
#2
Shima Mahmoudi, Babak Pourakbari, Mansoure Hosseini, Amir Esmaeil Alyari, Mohammad Taghi Haghi Ashtiani, Setareh Mamishi
INTRODUCTION: Pseudomonas aerouginosa is an important opportunistic pathogen causes clinical infections among ill patients. Metallo- Beta- lactamases (MBLs) are important mechanisms of carbapenem (drug of choice) resistance among Pseudomonas aerouginosa isolates. The aim of this study was to determine B- lactamases genes (bla-genes) in P. aerouginosa isolates and to detect percentage of MBLs among P. aerouginosa isolates in different wards. MATERIAL AND METHODS: Clinical isolates of P...
December 2, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27911110/mannose-binding-lectin-deficiency-in-brazilian-patients-with-spondyloarthritis
#3
Thelma L Skare, Renato Nisihara, Juliana Z Cieslinski, João O Zeni, Henrique N Rasera, Iara Messias-Reason, Shirley R R Utiyama
BACKGROUND: Infections are usually involved in the pathogenesis of spondyloarthritis (SpA). Mannose-binding lectin (MBL) is a component of the innate immune system with an important role in microbial defense. OBJECTIVE: To study the prevalence of MBL deficiency in SpA patients as well as its influence in the clinical profile of these diseases. METHODS: We studied 89 SpA patients and 89 healthy individuals, paired for age and gender. MBL serum levels were measured by ELISA test...
December 2, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27909766/association-between-tlr2-tlr4-gene-polymorphisms-and-copd-phenotype-in-a%C3%A2-greek-cohort
#4
A Apostolou, T Kerenidi, A Michopoulos, K I Gourgoulianis, M Noutsias, A E Germenis, M Speletas
BACKGROUND: Considering that the innate immune system plays a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD), we hypothesized that functional single-nucleotide polymorphisms (SNPs) of innate immune genes affect the disease phenotype and prognosis. AIM: To elucidate the contribution of common functional TLR2 and TLR4 SNPs and genotypic deficiency of the mannose-binding lectin (MBL) protein, both as single parameters and in combination, in Greek COPD patients...
December 1, 2016: Herz
https://www.readbyqxmd.com/read/27882088/study-on-the-resistance-mechanism-via-outer-membrane-protein-oprd2-and-metal-%C3%AE-lactamase-expression-in-the-cell-wall-of-pseudomonas-aeruginosa
#5
Shuangqi Cai, Yiqiang Chen, Dezhi Song, Jinliang Kong, Yanbin Wu, Huasong Lu
The aim of the present study was to evaluate the imipenem-resistant mechanism via the outer membrane protein (OMP) OprD2 and metal β-lactamase expression in the cell wall of Pseudomonas aeruginosa. The Pseudomonas aeruginosa was clinically separated and validated by VITEK-2 full-automatic bacteria analyzer. Drug resistance, sensitive antibiotics and minimum inhibitory concentration (MIC) were tested using the drug sensitivity analysis system. The phenotype positive strains of MBL genes were screened using the Kirby-Bauer diffusion method by adding metal ion-chelating agent EDTA on the imipenem susceptibility paper...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27865738/evaluation-of-the-modified-carbapenem-inactivation-method-and-sodium-mercaptoacetate-combination-method-for-the-detection-of-metallo-%C3%AE-lactamase-production-by-carbapenemase-producing-enterobacteriaceae
#6
Kageto Yamada, Machiko Kashiwa, Katsumi Arai, Noriyuki Nagano, Ryoichi Saito
We evaluated the effectiveness of carbapenem inactivation method (CIM) and modified CIM (mCIM). Our results indicated that mCIM with 4h incubation improved sensitivity and specificity for detecting carbapenemase-producing Enterobacteriaceae compared to CIM. Additionally, we developed a sodium mercaptoacetate-combination method (SMA-mCIM) to detect metallo-β-lactamase (MBL) with high sensitivity and specificity.
November 16, 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27857715/complementary-roles-of-the-classical-and-lectin-complement-pathways-in-the-defense-against-aspergillus-fumigatus
#7
Anne Rosbjerg, Ninette Genster, Katrine Pilely, Mikkel-Ole Skjoedt, Gregory L Stahl, Peter Garred
Aspergillus fumigatus infections are associated with a high mortality rate for immunocompromised patients. The complement system is considered to be important in protection against this fungus, yet the course of activation is unclear. The aim of this study was to unravel the role of the classical, lectin, and alternative pathways under both immunocompetent and immunocompromised conditions to provide a relevant dual-perspective on the response against A. fumigatus. Conidia (spores) from a clinical isolate of A...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27856789/collectins-h-ficolin-and-ll-37-reduce-influence-viral-replication-in-human-monocytes-and-modulate-virus-induced-cytokine-production
#8
Mitchell R White, Shweta Tripathi, Anamika Verma, Paul Kingma, Kazue Takahashi, Jens Jensenius, Steffen Thiel, Guangshun Wang, Erika C Crouch, Kevan L Hartshorn
Infiltrating activated monocytes are important mediators of damaging inflammation during influenza A virus (IAV) infection. We show that soluble respiratory proteins [collectins, surfactant proteins D (SP-D) and mannose binding lectin (MBL), H-ficolin and LL-37] inhibit replication of seasonal IAV in human monocytes. The collectins and H-ficolin also increased viral uptake by the cells, while LL-37 did not. H-ficolin was able to inhibit replication of the 2009 pandemic H1N1 strain (Cal09) in monocytes, but SP-D and LL-37 had significantly fewer inhibitory effects on this strain than on seasonal IAV...
November 17, 2016: Innate Immunity
https://www.readbyqxmd.com/read/27842992/systematic-review-and-meta-analysis-of-genetic-association-studies-in-idiopathic-recurrent-spontaneous-abortion
#9
Nina Pereza, Saša Ostojić, Miljenko Kapović, Borut Peterlin
OBJECTIVES: 1) To perform the first comprehensive systematic review of genetic association studies (GASs) in idiopathic recurrent spontaneous abortion (IRSA); 2) to analyze studies according to recurrent spontaneous abortion (RSA) definition and selection criteria for patients and control subjects; and 3) to perform meta-analyses for the association of candidate genes with IRSA. DESIGN: Systematic review and meta-analysis. SETTING: Not applicable...
November 11, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27836972/danger-lurking-in-the-unknowns-structure-to-function-studies-of-hypothetical-protein-bleg1_2437-from-bacillus-lehensis-g1-alkaliphile-revealed-an-evolutionary-divergent-b3-metallo-beta-lactamase
#10
Soo Huei Tan, Yahaya M Normi, Adam Thean Chor Leow, Abu Bakar Salleh, Abdul Munir Abdul Murad, Nor Muhammad Mahadi, Mohd Basyaruddin Abdul Rahman
The effectiveness of β-lactam antibiotics as chemotherapeutic agents to treat bacterial infections is gradually threatened with the emergence of antibiotic resistance mechanism among pathogenic bacteria through the production metallo-β-lactamase (MBL). In this study, we discovered a novel hypothetical protein (HP) termed Bleg1_2437 from the genome of alkaliphilic Bacillus lehensis G1 which exhibited MBL-like properties of B3 subclass; but evolutionary divergent from other circulating B3 MBLs. Domain and sequence analysis of HP Bleg1_2437 revealed that it contains highly conserved Zn(2+)-binding residues such as H54, H56, D58, H59, H131 and H191, important for catalysis, similar with the subclass B3 of MBL...
October 25, 2016: Journal of Biochemistry
https://www.readbyqxmd.com/read/27834790/the-structure-of-the-metallo-%C3%AE-lactamase-vim-2-in-complex-with-a-triazolylthioacetamide-inhibitor
#11
Tony Christopeit, Ke Wu Yang, Shao Kang Yang, Hanna Kirsti S Leiros
The increasing number of pathogens expressing metallo-β-lactamases (MBLs), and in this way achieving resistance to β-lactam antibiotics, is a significant threat to global public health. A promising strategy to treat such resistant pathogens is the co-administration of MBL inhibitors together with β-lactam antibiotics. However, an MBL inhibitor suitable for clinical use has not yet been identified. Verona integron-encoded metallo-β-lactamase 2 (VIM-2) is a widespread MBL with a broad substrate spectrum and hence is an interesting drug target for the treatment of β-lactam-resistant infections...
November 1, 2016: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/27826966/association-of-mbl-with-work-related-respiratory-symptoms-in-bakery-workers
#12
Mi Ae Kim, Moon Kyung Yoon, Seung Hyun Kim, Hae Sim Park
Baker's asthma is the most prevalent occupational asthma, and IgE-mediated response is known as a major pathogenesis. However, recent studies have suggested the involvement of innate immune response because wheat flour contains bacterial endotoxins or lipopolysaccharides. To further understand a role of innate immune response in the development of work-related respiratory symptoms (WRS) in bakery workers, we investigated mannose-binding lectin (MBL), one of the initiating components of the complement cascade in a single cohort of bakery workers...
January 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27824315/association-study-between-mannose-binding-lectin-haplotypes-and-x-gene-mutation-of-hepatitis-b-virus-from-treatment-na%C3%A3-ve-patients
#13
Chenghao Su, Yong Lin, Qianguo Mao, Daitze Wu, Lina Zhu, Isabel Najera, Fernando Garcia-Alcalde, Jianjun Niu
Mannose binding lectin (MBL) plays important role in the innate immunity of human. Mutations in the MBL2 gene can significantly change the serum level of MBL, and consequently alter the susceptibility and progression of infectious disease. However, the association between the MBL2 profile and the HBV mutation and quasispecies complexity has not yet been reported. Our approach includes the study of the MBL2 gene genotype as well as ultra-deep sequencing of the HBV viruses obtained from the plasma of 50 treatment naïve patients with chronic HBV infection...
November 7, 2016: Aging
https://www.readbyqxmd.com/read/27817988/expression-and-characterization-of-recombinant-chicken-mannose-binding-lectin
#14
Weidong Zhang, Martin van Eijk, Hongbo Guo, Albert van Dijk, Onno B Bleijerveld, M Hélène Verheije, Guanbo Wang, Henk P Haagsman, Edwin J A Veldhuizen
Mannose binding lectin (MBL) is a serum collagenous C-type lectin that plays an important role in the innate immune protection against pathogens. Previously, human and mouse studies have demonstrated that MBL binds a broad range of pathogens that results in their neutralization through agglutination, enhanced phagocytosis, and/or complement activation via the lectin pathway. The role of MBL in chicken is not well understood although the MBL concentration in serum seems to correlate with protection against infections...
October 29, 2016: Immunobiology
https://www.readbyqxmd.com/read/27812036/association-of-mannose-binding-lectin-polymorphisms-with-tuberculosis-susceptibility-among-chinese
#15
Cheng Liu, Tao He, Yanxiao Rong, Fengjiao Du, Dongxing Ma, Yujie Wei, Zhiqin Mei, Yuling Wang, Haibin Wang, Yuehua Zhu, Zongde Zhang, Li Zheng, Xueqiong Wu, Huiliang Liu, Wenjun Ding
Tuberculosis (TB) is caused by infection of Mycobacterium tuberculosis. Host genetic variability is an important determinant of the risk of developing TB in humans. Although the association between MBL2 polymorphisms and TB has been studied in various populations, the results are controversial. In this study four functional single-nucleotide polymorphisms (SNPs, H/L, X/Y, P/Q and A/B) across the MBL2 gene were genotyped by direct DNA sequencing of PCR products in a case-control population of Chinese Han origin, consisting of 1,020 patients with pulmonary TB and 1,020 controls...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27810495/psoriasis-risk-snps-and-their-association-with-hiv-1-control
#16
Joanne Nititham, Rashmi Gupta, Xue Zeng, Wendy Hartogensis, Douglas F Nixon, Steven G Deeks, Frederick M Hecht, Wilson Liao
Human evolution has resulted in selection for genetic polymorphisms beneficial in the defense against pathogens. However, such polymorphisms may have the potential to heighten the risk of autoimmune disease. Here, we investigated whether psoriasis-associated single nucleotide polymorphisms influence host control of HIV-1 infection. We studied psoriasis and viral immune response variants in three HIV-positive cohorts: (1) HIV-1 controllers and non-controllers in the Study of the Consequences of the Protease Inhibitor Era (SCOPE) cohort (n=366), (2) Individuals with primary HIV infection in the Options cohort (n=675), and (3) HIV-positive injection drug users from the Urban Health Study (UHS) (n=987)...
October 31, 2016: Human Immunology
https://www.readbyqxmd.com/read/27810007/the-global-challenge-in-neuroscience-education-and-training-the-mbl-perspective
#17
Rae Nishi, Edward Castañeda, Graeme W Davis, André A Fenton, Hans A Hofmann, Jean King, Timothy A Ryan, Keith A Trujillo
The greatest challenge in moving neuroscience research forward in the 21st century is recruiting, training, and retaining the brightest, rigorous, and most diverse scientists. The MBL research training courses Neurobiology and Neural Systems & Behavior, and the Summer Program in Neuroscience, Excellence, and Success provide a model for full immersion, discovery-based training while enhancing cultural, geographic, and racial diversity.
November 2, 2016: Neuron
https://www.readbyqxmd.com/read/27804178/the-influence-of-initial-alveolar-ridge-defect-morphology-on-the-outcome-of-implants-in-augmented-atrophic-posterior-mandible-an-exploratory-retrospective-study
#18
Arash Khojasteh, Saeed Reza Motamedian, Navid Sharifzadeh, Homayoun H Zadeh
OBJECTIVES: Clinicians commonly consider atrophic site topography as an important determinant in deciding the augmentation technique to utilize, as well as forecasting the likelihood of success. The purpose of this retrospective study was to examine the influence of initial atrophic posterior mandible morphology on the outcome of implants placed following augmentation. MATERIALS AND METHODS: A total of 52 patients contributed 71 edentulous sites, and 185 implants were placed with mean follow-up of 37...
November 2, 2016: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/27800466/emerging-carbapenem-resistant-pseudomonas-aeruginosa-isolates-carrying-blaimp-among-burn-patients-in-isfahan-iran
#19
Mohsen Radan, Rezvan Moniri, Ahmad Khorshidi, Hamidreza Gilasi, Zohreh Norouzi, Fahimeh Beigi, Yasaman Dasteh Goli
BACKGROUND: Metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa is a significant pathogen in burn patients. OBJECTIVES: The aim of this study was to determine the prevalence of carbapenem-resistant P. aeruginosa isolates, including those resistant to imipenemase (IMP), in a burn unit in Isfahan, Iran. PATIENTS AND METHODS: One hundred and fifty P. aeruginosa isolates from burn patients were tested for antibiotic susceptibility by the disc diffusion method in accordance with CLSI guidelines...
September 2016: Archives of Trauma Research
https://www.readbyqxmd.com/read/27798215/phenotypic-detection-of-the-cfia-metallo-%C3%AE-lactamase-in-bacteroides-fragilis-with-the-meropenem-edta-double-ended-etest-and-the-rosco-kpc-mbl-confirm-kit
#20
Simon A Schwensen, Ziyap Acar, Thomas V Sydenham, Åsa C Johansson, Ulrik S Justesen
OBJECTIVES: To investigate the performance of the meropenem and imipenem double-ended Etest ± EDTA and the tablet-based (meropenem and meropenem + dipicolinic acid) KPC/MBL Confirm Kit to detect cfiA metallo-β-lactamase (MBL) in Bacteroides fragilis. METHODS: Well-characterized B. fragilis isolates, most from previously published studies, harbouring the cfiA gene and covering a wide range of meropenem MICs were included (n = 21). RESULTS: The imipenem double-ended Etest showed an indeterminate result in 95% of the included isolates with the cfiA gene (20 of 21), whereas the meropenem double-ended Etest gave an MIC ratio ≥8 (positive test) with all the isolates...
October 20, 2016: Journal of Antimicrobial Chemotherapy
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