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https://www.readbyqxmd.com/read/29778048/pathogens-constancy-harbinger-of-nosocomial-infection-cum-identification-of-resistant-genes-and-drug-designing
#1
Sana Farooq Ahmad, Ibrar Khan, Abdul Wadood, Sadiq Azam, Noor Rehman, Muhammad Waqas, Kashif Bashir, Asaf Ali Khan
Hospitals are the most prominent places for the growth and spread of bacteria which are resistant to the available antibiotics. This antibiotic resistance is due to the over and misuse of antibiotic dosages of a high-density of patient population which are in frequent interaction with inanimate items of the hospitals and the consequent risk of cross infection. Out of 1010 samples of the current study, 510 (50.49%) were culture positive of which 329 (64.5%) were Gram-positive while 181 (35.49%) Gram negative...
April 22, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29776449/imipenem-resistance-in-clinical-escherichia-coli-from-qom-iran
#2
Saeed Shams, Ali Hashemi, Mohammad Esmkhani, Somaye Kermani, Elham Shams, Alessandra Piccirillo
OBJECTIVE: The emergence of metallo-β-lactamase-producing Enterobacteriaceae is a worldwide health concern. In this study, the first evaluation of MBL genes, bla IMP and bla VIM , in Escherichia coli resistant to imipenem isolated from urine and blood specimens in Qom, Iran is described. Three hundred urine and blood specimens were analysed to detect the presence of E. coli. Resistance to imipenem and other antimicrobials was determined by disk diffusion and MIC. MBL production was screened using CDDT...
May 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29775825/binding-capacity-of-mannose-binding-lectin-mbl-is-associated-with-the-severity-of-chronic-chagas-cardiomyopathy
#3
Elisa de A N Azevedo, Silvana Barreto, Raul Emídio de Lima, Romero Henrique Teixeira, George Diniz, Wilson Oliveira, Maria da Glória A M Cavalcanti, Yara M Gomes, Patrícia M M de F Moura, Clarice N L Morais
Chagas disease (CD) is a global problem. Currently, it affects approximately 15 million individuals in Latin America. It is well know that the human immune response is related to different clinical manifestations. Mannose binding lectin (MBL) plays an important role in innate immunity, and it mediates the phagocytosis and complement-mediated destruction of pathogens. The binding capacity is enhanced by the oligomerization of MBL. In this study, we evaluated the serum concentration and the binding capacity of MBL in patients with chronic chagasic cardiomyopathy...
May 15, 2018: Parasitology International
https://www.readbyqxmd.com/read/29773066/the-development-of-new-small-molecule-inhibitors-targeting-bacterial-metallo-%C3%AE-lactamases
#4
Ping Wang, Jing Cheng, Cong-Cong Liu, Kai Tang, Feng Xu, Zhiqiang Yu, Bin Yu, Junbiao Chang
Metallo-β-lactamases (MBLs) are a family of Zn(II)-dependent enzymes that can hydrolyze almost allβ-lactam antibiotics. Horizontal transferofthe genes encodingMBLsamong Gram-negative bacteria pathogens has led to the emergence of extensively drug-resistantpathogens, which now represent a major threat to human health.As there is not to date yet a clinicallyavailable MBL inhibitor, the discovery of new MBL inhibitors has great urgency. This review highlights the recent developments in the discovery of small-molecule MBL inhibitors...
May 17, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29772393/unexpected-mechanisms-of-resistance-in-dutch-pseudomonas-aeruginosa-isolates-collected-during-fourteen-years-of-surveillance
#5
P D Croughs, C H W Klaassen, J van Rosmalen, D M Maghdid, S A Boers, J P Hays, W H F Goessens
Pseudomonas aeruginosa is one of the most important causes of infection in the intensive care unit. It is intrinsically resistant to many antibiotics and easily acquires additional resistance genes via horizontal gene transfer of mobile genetic elements. In the present study, 1,528 P. aeruginosa isolates, obtained from a Dutch national surveillance program between the years 1998 and 2011, were analyzed for the presence of Extended Spectrum β-Lactamase (ESBL) genes blaCTX-M , blaSHV , blaTEM , blaBEL , blaPER , blaVEB , blaOXA-10 and metallo-β-Lactamase (MBL) genes blaIMP , blaVIM and blaNDM ...
May 14, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29770239/comparison-of-marginal-bone-loss-between-internal-and-external-connection-dental-implants-in-posterior-areas-without-periodontal-or-peri-implant-disease
#6
Dae-Hyun Kim, Hyun Ju Kim, Sungtae Kim, Ki-Tae Koo, Tae-Il Kim, Yang-Jo Seol, Yong-Moo Lee, Young Ku, In-Chul Rhyu
Purpose: The purpose of this retrospective study with 4-12 years of follow-up was to compare the marginal bone loss (MBL) between external-connection (EC) and internal-connection (IC) dental implants in posterior areas without periodontal or peri-implant disease on the adjacent teeth or implants. Additional factors influencing MBL were also evaluated. Methods: This retrospective study was performed using dental records and radiographic data obtained from patients who had undergone dental implant treatment in the posterior area from March 2006 to March 2007...
April 2018: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29769410/human-anti-thrombospondin-type-1-domain-containing-7a-antibodies-induce-membranous-nephropathy-through-activation-of-lectin-complement-pathway
#7
Zheng Wang, Lu Wen, Yanna Dou, Zhanzheng Zhao
To investigate whether the human anti-thrombospondin type 1 domain-containing 7A (THSD7A) antibody-induced membranous nephropathy is mediated by activating lectin complement pathway. Automatic biochemical apparatus was used to assess renal function of mice. The serum levels of anti-THSD7A antibodies and complement were tested by using Enzyme-linked immunosorbent assay (ELISA). The expression level of THSD7A and Mannose-Binding Lectin (MBL) in clinical tissue, and the histological features of MN in mice were examined by immunochemical methods...
May 16, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29762186/decision-making-for-management-of-periimplant-diseases
#8
Khaled Sinjab, Carlos Garaicoa-Pazmino, Hom-Lay Wang
INTRODUCTION: Nonsurgical and surgical management of periimplant mucositis and periimplantitis have shown promising results in arresting periimplant marginal bone loss (MBL) and preventing implant loss. However, management of periimplant diseases still remains unpredictable for full reconstruction of lost tissues and completely arrests disease progression. The present study proposes a decision tree that compiles both clinical and radiographic presentation of failing implants to aid in the decision making for their management...
May 11, 2018: Implant Dentistry
https://www.readbyqxmd.com/read/29760124/-in-vitro-activity-of-ceftazidime-avibactam-against-clinical-isolates-of-enterobacteriaceae-and-pseudomonas-aeruginosa-collected-in-asia-pacific-countries-results-from-the-inform-global-surveillance-program-2012-2015
#9
James A Karlowsky, Krystyna M Kazmierczak, Samuel K Bouchillon, Boudewijn L M de Jonge, Gregory G Stone, Daniel F Sahm
The in vitro activities of ceftazidime-avibactam and comparators were determined for 9,149 isolates of Enterobacteriaceae and 2,038 isolates of Pseudomonas aeruginosa collected by 42 medical centers in nine countries in the Asia-Pacific region from 2012 to 2015 as part of the International Network For Optimal Resistance Monitoring (INFORM) global surveillance program. Antimicrobial susceptibility testing was conducted by CLSI broth microdilution and isolate subset analysis performed based on resistant phenotypes and β-lactamase content...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29758855/ratios-of-greenhouse-gas-emissions-observed-over-the-yellow-sea-and-the-east-china-sea
#10
Yunsong Liu, Lingxi Zhou, Pieter P Tans, Kunpeng Zang, Siyang Cheng
During a cruise of the survey vessel Dongfanghong II on the Yellow Sea and the East China Sea in the spring of 2017 we performed accurate measurements of the mole fractions of carbon dioxide (CO2 ), methane (CH4 ), carbon monoxide (CO) and nitrous oxide (N2 O) using two types of Cavity Ring-Down Spectrometers (CRDS). The spatial variations of the mole fraction of the four trace gases were very similar. The emission sources of these gases were divided into several regions by using the NOAA HYSPLIT model. Then we analyzed the variations of the ratios of the mole fraction enhancements between every pair of trace gases downwind of these source areas...
August 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29758096/low-maternal-serum-concentrations-of-mannose-binding-lectin-mbl-are-associated-with-the-risk-of-shorter-duration-of-pregnancy-and-lower-birth-weight
#11
Michal Koucký, Karin Malíčková, Helena Kopřivová, Tereza Cindrová-Davies, Hana Hrbáčková, Andrej Černý, Patrik Šimják, Antonín Pařízek, Tomáš Zima
BACKROUND: Chronic inflammation has been implicated as the underlying mechanism responsible for the pathophysiology of preterm labor. Mannose-bindig lectin (MBL) plays a central role in the innate immune response and is thus an important component of the first line of defense. The aim of this study was to investigate whether serum concentrations of MBL correlated with the incidence of preterm birth and low birth weight in a cohort of women with signs of threatened preterm birth. METHODS: A cohort of 60 patients who presented with regular contractions and/or short cervix (group A) between 24 to 32 weeks of gestation and 20 healthy controls (group B) who had no pregnancy complications and delivered at term were recruited into a prospective study...
May 14, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29738817/effect-of-antimicrobial-photodynamic-therapy-in-open-flap-debridement-in-the-treatment-of-peri-implantitis-a-randomized-controlled-trial
#12
Abdulaziz M Albaker, Aws S ArRejaie, Mohammed Alrabiah, Khulud Abdulrahman Al-Aali, Sameer Mokeem, Mohammed N Alasqah, Fahim Vohra, Tariq Abduljabbar
BACKGROUND: To evaluate the effects of single application of antimicrobial photodynamic therapy (aPDT) as an adjunct to open flap debridement (OFD) and OFD alone in patients with peri-implantitis (PI). MATERIALS AND METHODS: Twenty four patients with PI were divided into 2 groups receiving aPDT with OFD and OFD alone respectively. Peri-implant plaque index (PI), bleeding on probing (BOP), pocket depth (PD) and marginal bone level (MBL) were assessed at baseline, 6 and 12 months post-therapy...
May 5, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29731790/prevalence-of-clinically-isolated-metallo-beta-lactamase-producing-pseudomonas-aeruginosa-coding-genes-and-possible-risk-factors-in-iran
#13
REVIEW
Abdolmajid Ghasemian, Kobra Salimian Rizi, Hassan Rajabi Vardanjani, Farshad Nojoomi
Background & Objective: The spread of carbapenem-resistant Pseudomonas aeruginosa is a global concern. Metallo-beta-lactamase (MBL) enzymes cause extensive drug resistance among Gram-negative bacteria. The current study aimed at determining the prevalence of MBL-producing P. aeruginosa in Iran. Data extraction: A total of 43 studies were found out of which 36 were adopted. Data were collected from Google, Google Scholar, Science Direct, PubMed, Scopus, Embase, and Sciverse...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29730815/pd-1-pd-l1-and-immune-related-gene-expression-pattern-in-pediatric-malignant-brain-tumors-clinical-correlation-with-survival-data-in-korean-population
#14
Kihwan Hwang, Eun Jung Koh, Eun Jin Choi, Tae Hee Kang, Jung Ho Han, Gheeyoung Choe, Sung-Hye Park, Jennifer Holmes Yearley, Lakshmanan Annamalai, Wendy Blumenschein, Manjiri Sathe, Terri McClanahan, Hun Jung, Kyu-Chang Wang, Seung-Ki Kim, Chae-Yong Kim
BACKGROUND: PD-L1 expression has been evaluated as a predictive biomarker for immunotherapy in numerous tumor types. However, very limited data are available in pediatric brain tumors. The aim of this study was to characterize PD-1 and PD-L1 expressions of four pediatric malignant brain tumors and gene expression profile. METHODS: This study included 89 pediatric patients receiving standard treatment at Seoul National University Children's Hospital and Seoul National University Bundang Hospital between 1990 and 2014: atypical teratoid/rhabdoid tumor (AT/RT) 20; ependymoma (EPN) 20; high grade glioma (HGG) 21; and medulloblastoma (MBL) 28...
May 5, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29729954/complement-activation-in-patients-with-diabetic-nephropathy
#15
X-Q Li, D-Y Chang, M Chen, M-H Zhao
AIM: Emerging evidence has indicated a role of the complement system in the pathogenesis of diabetic nephropathy (DN), although the pathways of complement activation and their clinicopathological relevance in DN are as yet unclear. The present study aimed to investigate levels of various complement components in plasma and urine of DN patients, and their correlation with clinicopathological parameters. METHODS: A total of 68 biopsy-proven DN patients with plasma samples were recruited, including 50 patients who also had urine samples available...
April 16, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29726673/vancomycin-analogue-restores-meropenem-activity-against-ndm-1-gram-negative-pathogens
#16
Venkateswarlu Yarlagadda, Paramita Sarkar, Sandip Samaddar, Goutham Belagula Manjunath, Susweta Das Mitra, Krishnamoorthy Paramanandham, Bibek R Shome, Jayanta Haldar
New Delhi Metallo-β-lactamase-1 (NDM-1) is the major contributor to the emergence of carbapenem-resistance in Gram-negative pathogens (GNPs) and has caused many clinically available β-lactam antibiotics to become obsolete. A clinically approved inhibitor of metallo-β-lactamase (MBL) that could restore the activity of carbapenems against resistant GNPs has not yet been found, making NDM-1 a serious threat to human health. Here, we have rationally developed an inhibitor for the NDM-1 enzyme, which has the ability to penetrate the outer membrane of GNPs and inactivate the enzyme by depleting the metal ion (Zn2+) from the active site...
May 4, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29725647/progressive-iga-nephropathy-is-associated-with-low-circulating-mannan-binding-lectin-associated-serine-protease-3-masp-3-and-increased-glomerular-factor-h-related-protein-5-fhr5-deposition
#17
Nicholas R Medjeral-Thomas, Anne Troldborg, Nicholas Constantinou, Hannah J Lomax-Browne, Annette G Hansen, Michelle Willicombe, Charles D Pusey, H Terence Cook, Steffen Thiel, Matthew C Pickering
Introduction: IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal injury. Methods: To elucidate the contribution of the lectin pathway to IgAN, we measured the 11 plasma lectin pathway components in a well-characterized cohort of patients with IgAN. Results: M-ficolin, L-ficolin, mannan-binding lectin (MBL)-associated serine protease (MASP)-1 and MBL-associated protein (MAp) 19 were increased, whereas plasma MASP-3 levels were decreased in patients with IgAN compared with healthy controls...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29725633/complement-activation-in-patients-with-diabetic-nephropathy
#18
Pascal Bus, Jamie S Chua, Céline Q F Klessens, Malu Zandbergen, Ron Wolterbeek, Cees van Kooten, Leendert A Trouw, Jan A Bruijn, Hans J Baelde
Introduction: Complement activation plays a role in various organs in patients with diabetes. However, in diabetic nephropathy (DN), the role of complement activation is poorly understood. We examined the prevalence and clinical significance of complement deposits in the renal tissue of cases with type 1 and type 2 diabetes with and without DN. Methods: We measured the prevalence of glomerular C4d, C1q, mannose-binding lectin (MBL), and C5b-9 deposits in 101 autopsied diabetic cases with DN, 59 autopsied diabetic cases without DN, and 41 autopsied cases without diabetes or kidney disease...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29717922/clinical-and-radiographic-evaluation-of-short-implants-placed-in-the-posterior-mandible-a-one-year-pilot-split-mouth-study
#19
Mireia Haro Adanez, Miha Brezavšček, Kirstin Vach, Manrique Fonseca, Wael Att
In many cases, due to anatomical limitations, the placement of regular-length implants cannot be facilitated without the performance of advanced surgical procedures. However, these are associated with morbidity, prolonged treatment time and costs. To overcome such disadvantages, short implants were introduced. The aim of this prospective pilot split-mouth study was to compare the clinical outcome between short implants (7 mm) and regular-length (≥10mm) implants placed in the posterior mandible after 1 year of prosthetic delivery...
May 2, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29692589/occurrence-of-bla-genes-encoding-carbapenem-resistant-pseudomonas-aeruginosa-and-acinetobacter-baumannii-from-intensive-care-unit-in-a-tertiary-care-hospital
#20
Jayanthi Siva Subramaniyan, Jeya Meenakshi Sundaram
CONTEXT: ICU shows increasing incidence of infection associated with the use of invasive procedures for the diagnostic purpose as well as the indiscriminate use of antibiotics. Pseudomonas aeruginosa and Acinetobacter species are "very successful" pathogen and the emergence of the Metallo-β-Lactamases (MBL) is becoming a therapeutic challenge. AIMS: To isolate the Nonfermenting Gram negative bacilli from the ICU samples. To identify the metallo betalactamase producers and to detect the bla gene presence among the Pseudomonas aeruginosa and Acinetobacter baumannii ...
April 2018: Journal of Laboratory Physicians
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