Cristiana Rodrigues, Paula Laranjeira, Aryane Pinho, Isabel Silva, Sandra Silva, Margarida Coucelo, Ana Catarina Oliveira, Ana Teresa Simões, Inês Damásio, Helena Matos Silva, Mafalda Urbano, Ana Bela Sarmento-Ribeiro, Catarina Geraldes, M Rosário Domingues, Julia Almeida, Ignacio Criado, Alberto Orfao, Artur Paiva
INTRODUCTION: In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear to be involved in autoimmune diseases and cancer. METHODS: Here, we quantified and phenotypically characterized CD20+ T cells from MBL subjects and CLL patients using flow cytometry and correlated our findings with the B-cell receptor mutational status and other features of the disease...
2024: Frontiers in Oncology