Jorge Lucas Teixeira-Fonseca, Diego Santos Souza, Michael Ramon de Lima Conceição, Leisiane Pereira Marques, Aimée Obolari Durço, Polyana Leal da Silva, Julliane V Joviano-Santos, Artur Santos-Miranda, Danilo Roman-Campos
Tebuconazole (TEB), a widely used pesticide in agriculture to combat fungal infections, is commonly detected in global food, potable water, groundwater, and human urine samples. Despite its known in vivo toxicity, its impact on heart function remains unclear. In a 28-day study on male Wistar rats (approximately 100 g), administering 10 mg/kg/day TEB or a control vehicle revealed no effect on body weight gain or heart weight, but an increase in the infarct area in TEB-treated animals. Notably, TEB induced time-dependent changes in in vivo electrocardiograms, particularly prolonging the QT interval after 28 days of administration...
March 29, 2024: Food and Chemical Toxicology