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antibiotics resistant genes

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https://www.readbyqxmd.com/read/28749495/characterization-of-a-highly-efficient-antibiotic-degrading-metallo-%C3%AE-lactamase-obtained-from-an-uncultured-member-of-a-permafrost-community
#1
Marcelo Monteiro Pedroso, Christopher Selleck, Charmaine Enculescu, Jeffrey R Harmer, Nataša Mitić, Whitney R Craig, Waleed Helweh, Philip Hugenholtz, Gene W Tyson, David L Tierney, James A Larrabee, Gerhard Schenk
Antibiotic resistance is a major global health problem, one that threatens to derail the benefits garnered from arguably the greatest success of modern medicine, the discovery of antibiotics. Among the most potent agents contributing to antibiotic resistance are metallo-β-lactamases (MBLs). The discovery of MBL-like enzymes in microorganisms that are not in contact with the human population is of particular concern as these proteins already have the in-built capacity to inactivate antibiotics, even though they may not need MBL activity for their survival...
July 27, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28748698/band-gap-engineering-of-titania-film-through-cobalt-regulation-for-oxidative-damage-of-bacteria-respiration-and-viability
#2
Jinhua Li, Jiaxing Wang, Donghui Wang, Geyong Guo, Kelvin Wai Kwok Yeung, Xianlong Zhang, Xuanyong Liu
Biomaterial-related bacterial infections cause patient suffering, mortality and extended periods of hospitalization, and impose a substantial burden on medical systems. In this context, understanding the interactions between nanomaterials and bacteria is clinically significant. Herein, TiO2-based heterojunctions including Co-TiO2, CoO-TiO2 and Co3O4-TiO2, were firstly designed by optimizing magnetron sputtering to establish a platform to explore the interactions between nanomaterials and bacteria. We found that the energy band bending and band gap narrowing were effectively promoted at the contact interface of the heterojunctions, which have the ability to induce abiotic reactive oxygen species formation...
July 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28748533/macrococcus-canis-and-m-caseolyticus-in-dogs-occurrence-genetic-diversity-and-antibiotic-resistance
#3
Kerstin Cotting, Christian Strauss, Sabrina Rodriguez-Campos, Ana Rostaher, Nina M Fischer, Petra J Roosje, Claude Favrot, Vincent Perreten
BACKGROUND: The discovery of a new Macrococcus canis species isolated from skin and infection sites of dogs led us to question if Macrococcus spp. are common in dogs and are resistant to antibiotics. HYPOTHESIS/OBJECTIVES: To evaluate the occurrence of Macrococcus spp. in dogs, determine antibiotic resistance profiles and genetic relationships. ANIMALS: One hundred and sixty two dogs (mainly West Highland white terriers and Newfoundland dogs) were screened for the presence of Macrococcus, including six dogs with Macrococcus infections...
July 26, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28747906/characterization-of-integrons-and-resistance-genes-in-salmonella-isolates-from-farm-animals-in-shandong-province-china
#4
Xiaonan Zhao, Jie Yang, Baozhen Zhang, Shuhong Sun, Weishan Chang
A total of 154 non-duplicate Salmonella isolates were recovered from 1,105 rectal swabs collected from three large-scale chicken farms (78/325, 24.0%), three large-scale duck farms (56/600, 9.3%) and three large-scale pig farms (20/180, 11.1%) between April and July 2016. Seven serotypes were identified among the 154 isolates, with the most common serotype in chickens and ducks being Salmonella enteritidis and in pigs Salmonella typhimurium. Antimicrobial susceptibility testing revealed that high antimicrobial resistance rates were observed for tetracycline (72...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28747788/klebsiella-pneumoniae-isolates-from-meningitis-epidemiology-virulence-and-antibiotic-resistance
#5
Yee-Huang Ku, Yin-Ching Chuang, Chi-Chung Chen, Mei-Feng Lee, Yan-Chang Yang, Hung-Jen Tang, Wen-Liang Yu
Klebsiella pneumoniae (KP) resistance to broad-spectrum cephalosporin (BSC) in meningitis is important because of limited therapeutic options. To investigate the antibiotic resistance, virulence and epidemiology of KP in meningitis, we conducted a retrospective study for 33 non-metastatic isolates, including primary meningitis (n = 20) and post-craniotomy meningitis (n = 13) collected from 1999 to 2013. BSC resistance was found in 9 (27.3%) isolates, all from post-craniotomy meningitis, harboring bla SHV-5 (n = 6), bla CMY-2 (n = 2), bla DHA-1 (n = 2), and bla TEM-1B (n = 1)...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747785/discovery-of-monoclonal-antibodies-cross-reactive-to-novel-subserotypes-of-k-pneumoniae-o3
#6
Luis M Guachalla, Katarina Stojkovic, Katharina Hartl, Marta Kaszowska, Yadhu Kumar, Benjamin Wahl, Tobias Paprotka, Eszter Nagy, Jolanta Lukasiewicz, Gábor Nagy, Valéria Szijártó
Klebsiella pneumoniae is responsible for nosocomial infections causing significant morbidity and mortality. Treatment of newly emerging multi-drug resistant strains is hampered due to severely limited antibiotic choices. Passive immunization targeting LPS O-antigens has been proposed as an alternative therapeutic option, given the limited variability of Klebsiella O-antigens. Here we report that the O3 serogroup, previously considered to have uniform O-antigen built of mannan, represents three different subtypes differing in the number of mannose residues within the O-antigen repeating units...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28746989/instability-of-the-incfii-type-plasmid-carrying-blandm-5-in-a-klebsiella-pneumoniae-isolate
#7
Juyoun Shin, Jin Yang Baek, Doo Ryeon Chung, Kwan Soo Ko
In this study, we characterized the blaNDM-5-bearing plasmid in a Klebsiella pneumoniae isolate that had lost the plasmid during serial passage. We determined the complete sequences of the plasmid pCC1410-2, which was extracted from a K. pneumoniae ST709 isolate collected at a Korean hospital from which two NDM-5-producing K. pneumoniae isolates were subsequently isolated. As a result, the pCC1410-2 plasmid had a backbone structure that was similar to those of two plasmids previously reported from the same hospital, but lacked some antibiotic resistance genes (blaTEM-1, rmtB, mphR(A), mrx(A), and mph(A))...
July 27, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28746396/recovery-of-metallo-tolerant-and-antibiotic-resistant-psychrophilic-bacteria-from-siachen-glacier-pakistan
#8
Muhammad Rafiq, Muhammad Hayat, Alexandre M Anesio, Syed Umair Ullah Jamil, Noor Hassan, Aamer Ali Shah, Fariha Hasan
Cultureable bacterial diversity of previously unexplored Siachen glacier, Pakistan, was studied. Out of 50 isolates 33 (66%) were Gram negative and 17 (34%) Gram positive. About half of the isolates were pigment producers and were able to grow at 4-37°C. 16S rRNA gene sequences revealed Gram negative bacteria dominated by Proteobacteria (especially γ-proteobacteria and β-proteobacteria) and Flavobacteria. The genus Pseudomonas (51.51%, 17) was dominant among γ- proteobacteria. β-proteobacteria constituted 4 (12...
2017: PloS One
https://www.readbyqxmd.com/read/28745822/dnri-of-streptomyces-peucetius-binds-to-the-resistance-genes-drrab-and-drrc-but-is-activated-by-daunorubicin
#9
Francis Prija, Padmanabhan Srinivasan, Subhadeep Das, Karuppasamy Kattusamy, Ranjan Prasad
The master regulator, DnrI of Streptomyces peucetius is a member of the family of transcriptional activator, Streptomyces antibiotic regulatory proteins (SARP), which controls the biosynthesis of antitumor anthracycline, daunorubicin (DNR) and doxorubicin (DXR). The binding of DnrI to the heptameric repeat sequence found within the -35 promoter region of biosynthetic gene, dpsE activates it. To combat the increased level of intracellular DNR, the cell has developed self resistance mechanism mediated by drrAB and drrC genes which are regulated by regulatory genes...
July 26, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/28743973/in-vivo-efficacy-of-%C3%AE-lactam-tripropeptin-c-in-a-mouse-septicemia-model-and-the-mechanism-of-reverse-%C3%AE-lactam-resistance-in-methicillin-resistant-staphylococcus-aureus-mediated-by-tripropeptin-c
#10
Hideki Hashizume, Yoshiaki Takahashi, Tohru Masuda, Shun-Ichi Ohba, Tomokazu Ohishi, Manabu Kawada, Masayuki Igarashi
Natural lipopeptide antibiotic tripropeptin C (TPPC) revitalizes and synergistically potentiates the activities of the class of β-lactam antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) but not against methicillin-sensitive S. aureus in vitro; however, the mode of action remains unclear. In the course of the study to reveal its mode of action, we found that TPPC inhibited the β-lactamase production induced by cefotiam. This prompted us to focus on the β-lactam-inducible β-lactam-resistant genes blaZ (β-lactamase) and mecA (foreign penicillin-binding protein), as they are mutually regulated by the blaZ/I/R1 and mecA/I/R1 systems...
July 26, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28743956/post-hypoxia-invasion-of-the-fetal-brain-by-multidrug-resistant-staphylococcus
#11
Miguel A Zarate, Michelle D Rodriguez, Eileen I Chang, Jordan T Russell, Thomas J Arndt, Elaine M Richards, Beronica A Ocasio, Eva Aranda, Elizabeth M Gordon, Kevin Yu, Josef Neu, Maureen Keller-Wood, Eric W Triplett, Charles E Wood
Herein we describe an association between activation of inflammatory pathways following transient hypoxia and the appearance of the multidrug resistant bacteria Staphylococcus simulans in the fetal brain. Reduction of maternal arterial oxygen tension by 50% over 30 min resulted in a subseiuent significant over-expression of genes associated with immune responses 24 h later in the fetal brain. The activated genes were consistent with stimulation by bacterial lipopolysaccharide; an influx of macrophages and appearance of live bacteria were found in these fetal brains...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28743810/polymyxin-combinations-combat-escherichia-coli-harboring-mcr-1-and-blandm-5-preparation-for-a-postantibiotic-era
#12
Zackery P Bulman, Liang Chen, Thomas J Walsh, Michael J Satlin, Yuli Qian, Jürgen B Bulitta, Charles A Peloquin, Patricia N Holden, Roger L Nation, Jian Li, Barry N Kreiswirth, Brian T Tsuji
The rapid increase of carbapenem resistance in Gram-negative bacteria has resurrected the importance of the polymyxin antibiotics. The recent discovery of plasmid-mediated polymyxin resistance (mcr-1) in carbapenem-resistant Enterobacteriaceae serves as an important indicator that the golden era of antibiotics is under serious threat. We assessed the bacterial killing of 15 different FDA-approved antibiotics alone and in combination with polymyxin B in time-killing experiments against Escherichia coli MCR1_NJ, the first reported isolate in the United States to coharbor mcr-1 and a New Delhi metallo-β-lactamase gene (blaNDM-5)...
July 25, 2017: MBio
https://www.readbyqxmd.com/read/28743652/molecular-epidemiology-of-carbapenem-resistant-klebsiella-pneumonia-at-a-turkish-center-is-the-increase-of-resistance-a-threat-for-europe
#13
Aslıhan Candevir Ulu, Tülin Güven Gökmen, Filiz Kibar, Behice Kurtaran, Cansu Önlen, Ferit Kuşçu, Ayşe Seza İnal, Süheyla Kömür, Akgün Yaman, Hasan Salih Zeki Aksu, Yeşim Taşova
INTRODUCTION: In recent years carbapenem resistant Klebsiella pneumoniae has became an important threat to hospitalized patients. Our aim in this study was to identify the genetic mechanisms of carbapenem resistance in our center. MATERIALS AND METHODS: In this study, a total of 98K. pneumoniae isolated from patients who registered at Cukurova University Balcali Hospital and determined phenotypically carbapenem resistant were screened for genotypic presence of carbapenemase enzymes with the multiplex-PCR in the period of 2013-2014...
July 22, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28742812/broad-range-lytic-bacteriophages-that-kill-staphylococcus-aureus-local-field-strains
#14
Virginia Abatángelo, Natalia Peressutti Bacci, Carina A Boncompain, Ariel A Amadio, Soledad Carrasco, Cristian A Suárez, Héctor R Morbidoni
Staphylococcus aureus is a very successful opportunistic pathogen capable of causing a variety of diseases ranging from mild skin infections to life-threatening sepsis, meningitis and pneumonia. Its ability to display numerous virulence mechanisms matches its skill to display resistance to several antibiotics, including β-lactams, underscoring the fact that new anti-S. aureus drugs are urgently required. In this scenario, the utilization of lytic bacteriophages that kill bacteria in a genus -or even species- specific way, has become an attractive field of study...
2017: PloS One
https://www.readbyqxmd.com/read/28742382/occurrence-and-antibiotic-susceptibility-of-listeria-species-and-staphylococcus-aureus-in-cattle-slaughterhouses-of-kerala-south-india
#15
Tanuja K G M Gowda, Latha C, Sunil B, Inge Van Damme
A total of 765 samples were collected from beef carcasses, knives, cutting table surfaces, beef, hands, air, and water from four cattle slaughterhouses of Kerala, South India, to determine the occurrence and antibiotic susceptibility of Listeria species and Staphylococcus aureus. Listeria spp. were isolated from beef carcasses (2.0%), knives (3.7%), cutting table surfaces (1.9%), beef (0.7%), and water (1.3%). The identified species were Listeria monocytogenes (0.1%), Listeria innocua (0.9%), and Listeria ivanovii (0...
July 25, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28742284/aquatic-animals-promote-antibiotic-resistance-gene-dissemination-in-water-via-conjugation-role-of-different-regions-within-the-zebra-fish-intestinal-tract-and-impact-on-fish-intestinal-microbiota
#16
Jialun Fu, Dong Yang, Min Jin, Weili Liu, Xin Zhao, Chenyu Li, Tianyu Zhao, Jingfeng Wang, Zhixian Gao, Zhiqiang Shen, Zhigang Qiu, Jun-Wen Li
The aqueous environment is one of many reservoirs of antibiotic resistance genes (ARGs). Fish, as important aquatic animals which possess ideal intestinal niches for bacteria to grow and multiply, may ingest antibiotic resistance bacteria from aqueous environment. The fish gut would be a suitable environment for conjugal gene transfer including those encoding antibiotic resistance. However, little is known in relation to the impact of ingested ARGs or ARB on gut microbiota. Here, we applied the cultivation method, qPCR, nuclear molecular genetic marker and 16S rDNA amplicon sequencing technologies to develop a plasmid-mediated ARG transfer model of zebrafish...
July 25, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28741095/phenotype-microarray-analysis-of-the-aders-two-component-system-in-acinetobacter-baumannii
#17
J-R Sun, Y-S Chiang, H-S Shang, C-L Perng, Y-S Yang, T-S Chiueh
Acinetobacter baumannii is a nosocomial pathogen capable of resistance to multiple antimicrobials. The AdeRS two-component system (TCS) is associated with antimicrobial resistance by controlling the AdeABC efflux pump. To elucidate modulation by AdeRS, we made an A. baumannii mutant lacking the AdeRS TCS and characterized it using phenotype microarray (PM) analysis. After disrupting the adeRS operon, lower expression of AdeABC efflux pump was observed in the mutant strain. PM analysis showed that the AdeRS deletion strain and parental strain presented different tolerances to 91 compounds...
July 24, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28740169/analysis-of-newly-detected-tetracycline-resistance-genes-and-their-flanking-sequences-in-human-intestinal-bifidobacteria
#18
Na Wang, Xiaomin Hang, Min Zhang, Xianglong Liu, Hong Yang
Due to tetracycline abuse, the safe bifidobacteria in the human gastrointestinal intestinal tract (GIT) may serve as a reservoir of tetracycline resistance genes. In the present investigation of 92 bifidobacterial strains originating from the human GIT, tetracycline resistance in 29 strains was mediated by the tet(W), tet(O) or tet(S) gene, and this is the first report of tet(O)- and tet(S)-mediated tetracycline resistance in bifidobacteria. Antibiotic resistance genes harbored by bifidobacteria are transferred from other bacteria...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28739795/clinical-characteristics-and-treatment-outcomes-of-patients-with-acquired-macrolide-resistant-mycobacterium-abscessus-lung-disease
#19
Hayoung Choi, Su-Young Kim, Dae Hun Kim, Hee Jae Huh, Chang-Seok Ki, Nam Yong Lee, Seung-Heon Lee, Soyoun Shin, Sung Jae Shin, Charles L Daley, Won-Jung Koh
Macrolide antibiotics are mainstays in the treatment of lung disease due to the Mycobacterium abscessus complex. Although previous studies have reported development of acquired macrolide resistance in this species, limited data are available on the outcomes of lung disease due to macrolide-resistant M. abscessus subspecies abscessus (hereafter M. abscessus). This study evaluated the clinical features, treatment outcomes, and molecular characteristics of macrolide-resistant isolates of M. abscessus We performed a retrospective review of medical records and genetic analysis of clinical isolates from 13 patients who had acquired macrolide-resistant M...
July 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28739786/benzoxazoles-phthalazinones-and-arylurea-based-compounds-with-impdh-independent-antibacterial-activity-against-francisella-tularensis
#20
Suresh Kumar Gorla, Yan Zhang, Meaghan M Rabideau, Aiping Qin, Shibin Chacko, Amanda L House, Corey R Johnson, Kavitha Mandapati, Hannah M Bernstein, Elizabeth S McKenney, Helena Boshoff, Minjia Zhang, Ian J Glomski, Joanna B Goldberg, Gregory D Cuny, Barbara J Mann, Lizbeth Hedstrom
Francisella tularensis is the causative agent of tularemia and a potential biowarfare agent. The virulence of F. tularensis is decreased by deletion of guaB, the gene encoding inosine monophosphate dehydrogenase (IMPDH), suggesting that this enzyme is a target for antibacterial design. Here we report that F. tularensis growth is blocked by inhibitors of bacterial IMPDHs. Seventeen compounds from two different frameworks, designated D and Q, display antibacterial activity with minimum inhibitory concentrations less than 1 μM...
July 24, 2017: Antimicrobial Agents and Chemotherapy
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