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ATACH-II

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https://www.readbyqxmd.com/read/24350872/interact2-a-reason-for-optimism-with-spontaneous-intracerebral-hemorrhage
#1
P Alan Barber, Timothy J Kleinig
The first Intensive Blood Pressure Reduction in Acute Intracerebral Hemorrhage Trial (INTERACT1) study found that early intensive BP lowering seemed to attenuate haematoma growth when compared with a more conservative guideline based policy. Clinicians were therefore waiting with anticipation for the results of INTERACT2, in which 2839 patients with spontaneous ICH and a systolic BP between 150 and 220 mmHg were randomly assigned to receive intensive anti-hypertensive therapy with a systolic target of <140 mmHg within one hour, or a standard guideline recommended treatment of <180 mmHg...
January 2014: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/24142579/acute-hypertensive-response-management-in-patients-with-acute-stroke
#2
REVIEW
Syeda L Alqadri, Varun Sreenivasan, Adnan I Qureshi
Acute elevation in blood pressure (acute hypertensive response) is commonly observed in the early period of both ischemic and hemorrhagic stroke. The management of acute hypertensive response depends upon the underlying intracranial pathology. Management of acute hypertensive response has been the focus of many trials and studies such as the SCAST trial, CHHIPS trial, COSSACS trial, INTERACT, and ATACH trial, which are discussed here. However, there were many limitations to these trials including time of presentation, different pathophysiology of ischemic strokes versus hemorrhagic strokes, and patient related factors...
December 2013: Current Cardiology Reports
https://www.readbyqxmd.com/read/23230462/mobile-applications-for-handheld-devices-to-screen-and-randomize-acute-stroke-patients-in-clinical-trials
#3
Ai Qureshi, B Connelly, Ei Abbott, E Maland, J Kim, J Blake
The availability of internet connectivity and mobile application software used by low-power handheld devices makes smart phones of unique value in time-sensitive clinical trials. Trial-specific applications can be downloaded by investigators from various mobile software distribution platforms or web applications delivered over HTTP. The Antihypertensive Treatment in Acute Cerebral Hemorrhage (ATACH) II investigators in collaboration with MentorMate released the ATACH-II Patient Recruitment mobile application available on iPhone, Android, and Blackberry in 2011...
August 2012: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/23230461/score-it-the-spot-sign-score-in-restricting-ich-growth%C3%A2-an-atach-ii-ancillary-study
#4
Jn Goldstein, Hb Brouwers, Jm Romero, K McNamara, K Schwab, Sm Greenberg, J Rosand
INTRODUCTION: The ATACH-II trial is designed to evaluate whether intensive blood pressure reduction can reduce hematoma growth and improve outcome. However, it is difficult to determine, at presentation, which patients are at highest risk of ongoing bleeding, and will receive the most clinical benefit from blood pressure therapy. It may be that improved predictive markers will lead to efficient, personalized selection of optimal therapy. We hypothesize that specific imaging findings on CT angiography (CTA) and MRI will mark those patients who receive the most benefit from intensive blood pressure reduction...
August 2012: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/23230459/the-importance-of-an-independent-oversight-committee-to-preserve-treatment-fidelity-ensure-protocol-compliance-and-adjudicate-safety-endpoints-in-the-atach-ii-trial
#5
Na McBee, Df Hanley, Cs Kase, K Lane, Jr Carhuapoma
In response to growing trends and accepted U.S. Food and Drug Administration (FDA) guidance, the ATACH II trial leadership developed the independent oversight committee (IOC) as a mechanism to adjudicate the trial safety endpoints and to evaluate treatment fidelity and protocol compliance. To accomplish these tasks, the IOC reviews the first three subjects enrolled at each study center and all serious adverse events that occur across all study centers. The IOC makes recommendations to the steering committee regarding the aggregation of, or trend in, adverse events at particular sites and discusses homogeneity, or lack thereof, in the principles and intensity of the overall care...
August 2012: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/23230458/expansion-of-recruitment-time-window-in-antihypertensive-treatment-of-acute-cerebral-hemorrhage-atach-ii-trial
#6
Ai Qureshi, Yy Palesch
The Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH) II trial is an ongoing multi-center, randomized phase III trial to determine the efficacy of early, intensive, antihypertensive treatment using intravenous (IV) nicardipine initiated within 3 h of onset of intracerebral hemorrhage (ICH). On March 11th, 2012, the National Institutes of Neurological Disorders and Stroke approved recruitment of patients with ICH within 4.5 h of symptom onset. The expansion of recruitment window was based on the recent ATACH-I study analysis that suggests reduction of hematoma expansion and death, and disability in those subjects who were treated within 4...
August 2012: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/23230457/run-up-to-participation-in-atach-ii-in-japan
#7
K Toyoda, S Sato, M Koga, H Yamamoto, J Nakagawara, E Furui, Y Shiokawa, Y Hasegawa, S Okuda, N Sakai, K Kimura, Y Okada, S Yoshimura, H Hoshino, Y Uesaka, T Nakashima, Y Itoh, T Ueda, T Nishi, J Gotoh, K Nagatsuka, S Arihiro, T Yamaguchi, K Minematsu
Intracerebral hemorrhage (ICH) is a major cause of morbidity and mortality in Japan. Seventeen Japanese institutions are participating in the Antihypertensive Treatment for Acute Cerebral Hemorrhage (ATACH) II Trial (ClinicalTrials.gov no. NCT01176565; UMIN 000006526). This phase III trial is designed to determine the therapeutic benefit of early intensive systolic blood pressure (BP) lowering for acute hypertension in ICH patients. This report explains the long run-up to reach the start of patient registration in ATACH II in Japan, including our preliminary study, a nationwide survey on antihypertensive treatment for acute ICH patients, a multicenter study for hyperacute BP lowering (the SAMURAI-ICH study), revision of the official Japanese label for intravenous nicardipine, and construction of the infrastructure for the trial...
August 2012: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/23196532/-medical-therapy-for-intracranial-hemorrhage-update-blood-pressure-management-for-prevention-and-acute-treatment
#8
Masatoshi Koga, Kazunori Toyoda
Intracerebral hemorrhage (ICH) is a common stroke subtype in Japan. Hypertension is the leading cause. Perindopril Protection Against Recurrent Stroke Study (PROGRESS) revealed that blood pressure (BP) lowering could reduce stroke recurrence by 28% (ICH recurrence by 49%). The guideline for the management of hypertension (JSH2009) recommends BP control of ≤ 140/90 mm Hg for patients with prior stroke. BP is frequently elevated in acute ICH, although BP management strategy is controversial. The guideline from the American Stroke Association suggests if systolic BP (SBP) >180 mm Hg and there is no evidence of elevated intracranial pressure, then consider a modest reduction of BP...
2012: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/22989898/-antihypertensive-treatment-of-acute-cerebral-hemorrhage-atach-ii-at-japan-site-study-design-and-advance-construction-of-domestic-research-network
#9
Shoichiro Sato, Haruko Yamamoto, Adnan I Qureshi, Yuko Y Palesch, Kazunori Toyoda
The Antihypertensive Treatment for Acute Cerebral Hemorrhage (ATACH)-II Trial (ClinicalTrials.gov no. NCT01176565; (UMIN 000006526) is an international, multicenter, randomized, concurrently-controlled, parallel arm, Phase III trial to determine the therapeutic benefit of early intensive systolic blood pressure (SBP) lowering compared with standard SBP lowering for acute hypertension in patients with spontaneous intracerebral hemorrhage (ICH). The Trial is funded by the National Institutes of Health in the United States and led by Dr...
2012: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/22700471/management-of-acute-hypertensive-response-in-patients-with-intracerebral-hemorrhage
#10
Syeda L Alqadri, Adnan I Qureshi
Spontaneous intracerebral hemorrhage (ICH) is intra-parenchymal bleeding that may lead to localized hematoma formation. The hematoma can enlarge over a period of time, and directly contribute to neurological deterioration and death. Several studies have shown a relationship between acute hypertensive response and poor prognosis among patients with ICH; however, it is somewhat unclear whether hematomal expansion, is a cause or a result of elevated blood pressure (BP). Current AHA guidelines state MAP should be maintained <130 mmHg and systolic blood pressure (SBP) <180 mmHg...
August 2012: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/22322257/blood-pressure-control-for-acute-ischemic-and-hemorrhagic-stroke
#11
REVIEW
Erin M Grise, Opeolu Adeoye
PURPOSE OF REVIEW: Acute stroke, including the subtypes of ischemic stroke, intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH), typically involves significant fluctuations in blood pressure (BP). Treatment of BP after all stroke types is controversial. In each case, there are theoretical dangers to leaving BP alone as well as altering it artificially. In this article, we review the role of BP in each stroke subtype and the existing evidence for BP optimization. RECENT FINDINGS: Except in patients receiving thrombolytic therapy, there is insufficient evidence to recommend active BP management in ischemic stroke...
April 2012: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/21626077/antihypertensive-treatment-of-acute-cerebral-hemorrhage-atach-ii-design-methods-and-rationale
#12
RANDOMIZED CONTROLLED TRIAL
A I Qureshi, Y Y Palesch
The December 2003 report from the National Institute of Neurological Disorders and Stroke (NINDS) Workshop on priorities for clinical research in intracerebral hemorrhage (ICH) recommended clinical trials for evaluation of blood pressure management in acute ICH as a leading priority. The Special Writing Group of the Stroke Council of the American Heart Association in 1999 and 2007 emphasized the need for clinical trials to ensure evidence-based treatment of acute hypertensive response in ICH. To address important gaps in knowledge, we conducted a pilot study funded by the NINDS, Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH) I Trial, during 2004-2008 to determine the appropriate level of systolic blood pressure (SBP) reduction...
December 2011: Neurocritical Care
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