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https://www.readbyqxmd.com/read/28231394/adaptive-divergence-in-wine-yeasts-and-their-wild-relatives-suggests-a-prominent-role-for-introgressions-and-rapid-evolution-at-non-coding-sites
#1
Pedro Almeida, Raquel Barbosa, Douda Bensasson, Paula Gonçalves, José Paulo Sampaio
In Saccharomyces cerevisiae, the main yeast in wine fermentation, the opportunity to examine divergence at the molecular level between a domesticated lineage and its wild counterpart arose recently due to the identification of the closest relatives of wine strains, a wild population associated with Mediterranean oaks. Since genomic data is available for a considerable number of representatives belonging to both groups, we used population genomics to estimate the degree and distribution of nucleotide variation between wine yeasts and their closest wild relatives...
February 23, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28230996/a-facile-n-mercaptoethoxyglycinamide-mega-linker-ap-proach-to-peptide-thioesterification-and-cyclization
#2
Patrick M M Shelton, Caroline E Weller, Champak Chatterjee
The C-terminal selective electrophilic activation of polypeptides is essential for site-specific peptide mod-ification and conjugation techniques such as Native Chemi-cal Ligation (NCL). Peptide C-terminal α-thioesters are par-ticularly valuable precursors for NCL, due to their hydrolytic stability in aqueous buffers and reactivity toward thiol nucle-ophiles. The synthesis of peptide α-thioesters, however, re-quires harsh acidic conditions or complex chemical manipu-lations, which ultimately limits their functional group com-patibility and broad utility...
February 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28230706/first-presentation-acute-rheumatic-fever-is-preventable-in-a-community-setting-a-school-based-intervention
#3
Diana Lennon, Philippa Anderson, Melissa Kerdemelidis, Elizabeth Farrell, Suzanne Crengle Mahi, Teuila Percival, David Jansen, Joanna Stewart
BACKGROUND: Robust evidence is lacking for community initiatives to prevent first presentation acute rheumatic fever (ARF) by group A streptococcal (GAS) pharyngitis treatment. METHODS: We measured the effect of introducing a sore throat clinic program on first presentation ARF into 61 year 1-8 schools with students aged 5-13years (population ~ 25,000) in Auckland, New Zealand. The study period was 2010-2016. A generalized linear mixed model investigated ARF rate changes before and after the staggered introduction of school clinics...
February 22, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28230275/the-development-and-correlates-of-gender-role-attitudes-in-african-american-youth
#4
Chun Bun Lam, Christine Stanik, Susan M McHale
This research examined the longitudinal trajectories and family correlates of gender role attitudes in African American youth in a sample of 166 sibling pairs residing with their mothers and fathers. Multilevel modelling revealed that (1) girls and boys exhibited significant declines in gender attitude traditionality from ages 9 to 15 that levelled off through age 18, (2) mothers' (but not fathers') gender role attitude traditionality was positively related to youth's attitude traditionality, and (3) within-person variation in mothers' (but not fathers') racial discrimination experiences was negatively related to within-person variation in youth's gender role attitude traditionality...
February 23, 2017: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/28229455/maternal-perinatal-and-concurrent-depressive-symptoms-and-child-behavior-problems-a-sibling-comparison-study
#5
Line C Gjerde, Espen Moen Eilertsen, Ted Reichborn-Kjennerud, Tom A McAdams, Henrik Daae Zachrisson, Imac Maria Zambrana, Espen Røysamb, Kenneth S Kendler, Eivind Ystrom
BACKGROUND: Previous studies have found significant associations between maternal prenatal and postpartum depression and child behavior problems (CBP). The present study investigates whether associations remain in a prospective, longitudinal design adjusted for familial confounding. METHODS: The sample comprised 11,599 families including 17,830 siblings from the Norwegian Mother and Child Cohort study. Mothers reported depressive symptoms at gestational weeks 17 and 30, as well as 6 months, 1...
February 23, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28225906/the-current-status-of-the-lutzomyia-longipalpis-diptera-psychodidae-phlebotominae-species-complex
#6
Nataly A Souza, Reginaldo P Brazil, Alejandra S Araki
Lutzomyia longipalpis s.l. is a complex of sibling species and is the principal vector of American visceral leishmaniasis. The present review summarises the diversity of efforts that have been undertaken to elucidate the number of unnamed species in this species complex and the phylogenetic relationships among them. A wide variety of evidence, including chemical, behavioral and molecular traits, suggests very recent speciation events and complex population structure in this group. Although significant advances have been achieved to date, differential vector capacity and the correlation between structure of parasite and vector populations have yet to be elucidated...
March 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28225781/chronic-pain-depression-and-cardiovascular-disease-linked-through-a-shared-genetic-predisposition-analysis-of-a-family-based-cohort-and-twin-study
#7
Oliver van Hecke, Lynne J Hocking, Nicola Torrance, Archie Campbell, Sandosh Padmanabhan, David J Porteous, Andrew M McIntosh, Andrea V Burri, Haruka Tanaka, Frances M K Williams, Blair H Smith
BACKGROUND: Depression and chronic pain are the two most important causes of disability (Global Burden of Disease Study 2013). They occur together more frequently than expected and both conditions have been shown to be co-morbid with cardiovascular disease. Although shared socio-demographic risk factors (e.g. gender, deprivation) might explain the co-morbidity of these three conditions, we hypothesised that these three long-term, highly prevalent conditions co-occur and may be due to shared familial risk, and/or genetic factors...
2017: PloS One
https://www.readbyqxmd.com/read/28224435/factors-associated-with-trait-anger-level-of-juvenile-offenders-in-hubei-province-a-binary-logistic-regression-analysis
#8
Li-Na Tang, Xiao-Zhou Ye, Qiu-Ge Yan, Hong-Juan Chang, Yu-Qiao Ma, De-Bin Liu, Zhi-Gen Li, Yi-Zhen Yu
The risk factors of high trait anger of juvenile offenders were explored through questionnaire study in a youth correctional facility of Hubei province, China. A total of 1090 juvenile offenders in Hubei province were investigated by self-compiled social-demographic questionnaire, Childhood Trauma Questionnaire (CTQ), and State-Trait Anger Expression Inventory-II (STAXI-II). The risk factors were analyzed by chi-square tests, correlation analysis, and binary logistic regression analysis with SPSS 19.0. A total of 1082 copies of valid questionnaires were collected...
February 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28224345/electrophysiological-endophenotypes-and-the-error-related-negativity-ern-in-autism-spectrum-disorder-a-family-study
#9
Ann Clawson, Mikle South, Scott A Baldwin, Michael J Larson
We examined the error-related negativity (ERN) as an endophenotype of ASD by comparing the ERN in families of ASD probands to control families. We hypothesized that ASD probands and families would display reduced-amplitude ERN relative to controls. Participants included 148 individuals within 39 families consisting of a mother, father, sibling, and proband. Robust ANOVAs revealed non-significant differences in ERN amplitude and behavioral performance among ASD probands relative to control youth. In subsequent multiple regression analyses group and kinship (proband, sibling, mother, father) did not significantly predict ΔERN (error minus correct ERN) or behavioral performance...
February 21, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28224344/brief-report-characteristics-of-preschool-children-with-asd-vary-by-ascertainment
#10
Lori-Ann R Sacrey, Lonnie Zwaigenbaum, Peter Szatmari, Susan Bryson, Stelios Georgiades, Jessica Brian, Isabel M Smith, Tracy Vaillancourt, Nancy Garon, Caroline Roncadin, Mayada Elsabbagh
Prospective studies of infant siblings of children diagnosed with autism spectrum disorder (ASD) provide a unique opportunity to characterize ASD as it unfolds. A critical question that remains unanswered is whether and how these children with ASD resemble other children identified from the community, including those with no family history. The purpose of this study was to compare clinical characteristics of children with ASD identified by each method (n = 86 per group), drawn from two Canadian longitudinal research cohorts...
February 21, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28224043/pleiotropic-effect-of-a-novel-mutation-in-gcnt2-causing-congenital-cataract-and-a-rare-adult-i-blood-group-phenotype
#11
Sek-Shir Cheong, Sarah Hull, Benjamin Jones, Ravinder Chana, Nicole Thornton, Vincent Plagnol, Anthony T Moore, Alison J Hardcastle
Mutations in GCNT2 have been associated with the rare adult i blood group phenotype with or without congenital cataract. We report a novel homozygous frameshift mutation c.1163_1166delATCA, p.(Asn388Argfs*20) as the cause of congenital cataract in two affected siblings. Blood group typing confirmed that both affected males have the rare adult i phenotype, supporting the hypothesis that the partial association of I/i phenotype and congenital cataract is due to the differential expression of GCNT2 isoforms.
2017: Human Genome Variation
https://www.readbyqxmd.com/read/28223732/effects-of-sex-and-generation-on-hepatitis-b-viral-load-in-families-with-hepatocellular-carcinoma
#12
Ai-Ru Hsieh, Cathy Sj Fann, Chau-Ting Yeh, Hung-Chun Lin, Shy-Yi Wan, Yi-Cheng Chen, Chia-Lin Hsu, Jennifer Tai, Shi-Ming Lin, Dar-In Tai
AIM: To explore factors associated with persistent hepatitis B virus (HBV) infection in a cohort of hepatocellular carcinoma (HCC)-affected families and then investigate factors that correlate with individual viral load among hepatitis B surface antigen (HBsAg)-positive relatives. METHODS: We evaluated non-genetic factors associated with HBV replication in relatives of patients with HCC. Relatives of 355 HCC cases were interviewed using a structured questionnaire...
February 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28223467/hypertension-in-pregnancy-and-offspring-cardiovascular-risk-in-young-adulthood-prospective-and-sibling-studies-in-the-hunt-study-nord-tr%C3%A3-ndelag-health-study-in-norway
#13
Ingvild V Alsnes, Lars J Vatten, Abigail Fraser, Johan Håkon Bjørngaard, Janet Rich-Edwards, Pål R Romundstad, Bjørn O Åsvold
Women with hypertensive disorders in pregnancy are at increased lifetime risk for cardiovascular disease. We examined the offspring's cardiovascular risk profile in young adulthood and their siblings' cardiovascular risk profile. From the HUNT study (Nord-Trøndelag Health Study) in Norway, 15 778 participants (mean age: 29 years), including 210 sibling groups, were linked to information from the Medical Birth Registry of Norway. Blood pressure, anthropometry, serum lipids, and C-reactive protein were assessed...
February 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28223422/a-potential-oligogenic-etiology-of-hypertrophic-cardiomyopathy-a-classic-single-gene-disorder
#14
Lili Li, Matthew N Bainbridge, Yanli Tan, James T Willerson, Ali J Marian
Rationale: Hypertrophic cardiomyopathy (HCM) is a prototypic single gene disease caused mainly by mutations in genes encoding sarcomere proteins. Despite the remarkable advances, the causal genes in about 40% of the HCM cases remain unknown, typically in small families and sporadic cases, wherein co-segregation could not be established. Objective: To test the hypothesis that the "missing causal genes" in HCM is, in part, because of an oligogenic etiology, wherein the pathogenic variants do not co-segregate with the phenotype...
February 21, 2017: Circulation Research
https://www.readbyqxmd.com/read/28222800/exome-sequencing-identifies-slc26a4-gjb2-scarb2-and-duox2-mutations-in-2-siblings-with-pendred-syndrome-in-a-malaysian-family
#15
Yock-Ping Chow, Nor Azian Abdul Murad, Zamzureena Mohd Rani, Jia-Shiun Khoo, Pei-Sin Chong, Loo-Ling Wu, Rahman Jamal
BACKGROUND: Pendred syndrome (PDS, MIM #274600) is an autosomal recessive disorder characterized by congenital sensorineural hearing loss and goiter. In this study, we describing the possible PDS causal mutations in a Malaysian family with 2 daughters diagnosed with bilateral hearing loss and hypothyroidism. METHODS AND RESULTS: Whole exome sequencing was performed on 2 sisters with PDS and their unaffected parents. Our results showed that both sisters inherited monoallelic mutations in the 2 known PDS genes, SLC26A4 (ENST00000265715:c...
February 21, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28222787/an-effective-method-for-the-identification-and-separation-of-anopheles-minimus-the-primary-malaria-vector-in-thailand-and-its-sister-species-anopheles-harrisoni-with-a-comparison-of-their-mating-behaviors
#16
Kritsana Taai, Ralph E Harbach, Kittipat Aupalee, Wichai Srisuka, Thippawan Yasanga, Yasushi Otsuka, Atiporn Saeung
BACKGROUND: Species of the Anopheles minimus complex are considered to be the primary vectors of malaria in South and Southeast Asia. Two species of the complex, Anopheles minimus and Anopheles harrisoni, occur in Thailand. They are sympatric and difficult to accurately distinguish based on morphological characters. The aim of this study was to investigate the potential of antennal sensory organs to distinguish these two species. Additionally, we investigated their ability to mate in cages of different sizes, as well as the possible mechanism(s) that evokes stenogamous behavior...
February 21, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28221829/the-evolutionary-economics-of-embryonic-sac-fluids-in-squamate-reptiles
#17
Xavier Bonnet, Guy Naulleau, Richard Shine
The parchment-shelled eggs of squamate reptiles take up substantial water from the nest environment, enabling the conversion of yolk into neonatal tissue and buffering the embryo against the possibility of subsequent dry weather. During development, increasing amounts of water are stored in the embryonic sacs (i.e., membranes around the embryo: amnion, allantois, and chorion). The evolution of viviparity (prolonged uterine retention of developing embryos) means that embryonic-sac fluid storage now imposes a cost (increased maternal burdening), confers less benefit (because the mother buffers fetal water balance), and introduces a potential conflict among uterine siblings (for access to finite water supplies)...
March 2017: American Naturalist
https://www.readbyqxmd.com/read/28221827/hormonally-mediated-increases-in-sex-biased-gene-expression-accompany-the-breakdown-of-between-sex-genetic-correlations-in-a-sexually-dimorphic-lizard
#18
Robert M Cox, Christian L Cox, Joel W McGlothlin, Daren C Card, Audra L Andrew, Todd A Castoe
The evolution of sexual dimorphism is predicted to occur through reductions in between-sex genetic correlations (rmf) for shared traits, but the physiological and genetic mechanisms that facilitate these reductions remain largely speculative. Here, we use a paternal half-sibling breeding design in captive brown anole lizards (Anolis sagrei) to show that the development of sexual size dimorphism is mirrored by the ontogenetic breakdown of rmf for body size and growth rate. Using transcriptome data from the liver (which integrates growth and metabolism), we show that sex-biased gene expression also increases dramatically between ontogenetic stages bracketing this breakdown of rmf...
March 2017: American Naturalist
https://www.readbyqxmd.com/read/28220708/epidemiology-and-antibiotic-sensitivity-of-staphylococcus-aureus-nasal-carriage-in-children-in-hungary
#19
Krisztina Laub, Adrienn Tóthpál, Szilvia Kardos, Orsolya Dobay
The aim of this study was to assess the Staphylococcus aureus nasal carriage rate in healthy children all over Hungary and to specify some risk factors, the antibiotic resistance patterns of the bacteria, and their genetic relatedness. In total, 878 children (aged 3-6 years) were screened at 21 day-care centers in 16 different cities in Hungary, between February 2009 and December 2011. Samples taken from both nostrils were cultured on blood agar, and suspected S. aureus isolates were identified by β-hemolysis, catalase positivity, clump test, and nucA PCR...
February 21, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28220259/mutations-in-kiaa0753-cause-joubert-syndrome-associated-with-growth-hormone-deficiency
#20
Joshi Stephen, Thierry Vilboux, Luhe Mian, Chulaluck Kuptanon, Courtney M Sinclair, Deniz Yildirimli, Dawn M Maynard, Joy Bryant, Roxanne Fischer, Meghana Vemulapalli, James C Mullikin, Marjan Huizing, William A Gahl, May Christine V Malicdan, Meral Gunay-Aygun
Joubert syndrome and related disorders (JSRD) are a heterogeneous group of ciliopathies defined based on the mid-hindbrain abnormalities that result in the characteristic "molar tooth sign" on brain imaging. The core clinical findings of JSRD are hypotonia, developmental delay, abnormal eye movements and breathing abnormalities. To date, more than 30 JSRD genes that encode proteins important for structure and/or function of cilia have been identified. Here, we present 2 siblings with Joubert syndrome associated with growth hormone deficiency...
February 20, 2017: Human Genetics
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