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https://www.readbyqxmd.com/read/27776952/prolactin-gene-polymorphism-1149-g-t-is-associated-with-hyperprolactinemia-in-patients-with-schizophrenia-treated-with-antipsychotics
#1
Svetlana A Ivanova, Diana Z Osmanova, Anastasia S Boiko, Ivan V Pozhidaev, Maxim B Freidin, Olga Yu Fedorenko, Arkadiy V Semke, Nikolay A Bokhan, Elena G Kornetova, Lubov D Rakhmazova, Bob Wilffert, Anton J M Loonen
BACKGROUND: Antipsychotic drugs can cause hyperprolactinemia. However, hyperprolactinemia was also observed in treatment-naive patients with a first schizophrenic episode. This phenomenon might be related to the role of prolactin as a cytokine in autoimmune diseases. Extrapituitary prolactin production is regulated by an alternative promoter, which contains the functional single nucleotide polymorphism -1149 G/T (rs1341239). We examined whether this polymorphism was associated with hyperprolactinemia in patients with schizophrenia...
October 21, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27711937/il-4-tgf-%C3%AF-nf-%C3%AF-b-and-mpo-levels-in-patients-with-treatment-resistant-schizophrenia
#2
Şükrü Kartalcı, Lale Gönenir Erbay, Esra Porgalı Zayman, Önder Otlu, Aysun Bay Karabulut, Gülşen Kartalcı
OBJECTIVE: Schizophrenia is a chronic psychotic disorder in which genetics and environmental factors such as infection and the corresponding immune response play a role in the etiopathogenesis. The aim of this study was to compare some immune factors such as nuclear factor-B (NF-B) activation, myeloperoxidase (MPO), the anti-inflammatory cytokine interleukin-4 (IL-4), and regulatory cytokine transforming growth factor- (TGF-) in schizophrenia patients and an age- and gender-matched control group...
2016: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/27606316/inflammatory-cytokines-and-antipsychotic-induced-weight-gain-review-and-clinical-implications
#3
REVIEW
Trehani M Fonseka, Daniel J Müller, Sidney H Kennedy
Antipsychotic medications (APs), particularly second-generation APs, are associated with significant weight gain in schizophrenia patients. Recent evidence suggests that the immune system may contribute to antipsychotic-induced weight gain (AIWG) via AP-mediated alterations of cytokine levels. Antipsychotics with a high propensity for weight gain, such as clozapine and olanzapine, influence the expression of immune genes, and induce changes in serum cytokine levels to ultimately down-regulate neuroinflammation...
May 2016: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/27471446/taurine-and-epidermal-growth-factor-belong-to-the-signature-of-first-episode-psychosis
#4
Kati Koido, Jürgen Innos, Liina Haring, Mihkel Zilmer, Aigar Ottas, Eero Vasar
This study evaluated the levels of two amino acid derivatives taurine and spermine in first-episode psychosis (FEP) patients and their response to antipsychotic treatment. The levels of taurine and spermine were significantly up-regulated in antipsychotic-naïve FEP patients compared to control subjects (CS). Treatment of FEP patients with antipsychotic drugs significantly reduced the positive symptoms of schizophrenia. This positive effect was accompanied by a significant reduction of taurine and spermine to the levels measured in CS...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27470381/celecoxib-and-omega-3-fatty-acids-alone-and-in-combination-with-risperidone-affect-the-behavior-and-brain-biochemistry-in-amphetamine-induced-model-of-schizophrenia
#5
Alaa El-Sayed El-Sisi, Samia Salem Sokkar, Magda El-Sayed El-Sayad, Ehab Sayed Ramadan, Enass Yossef Osman
The implications of oxidative stress and neuro-inflammation in the pathogenesis of schizophrenia have been elucidated. Despite their effectiveness against positive symptoms of schizophrenia, antipsychotics have limited effectiveness against negative and cognitive symptoms and are associated with remarkable adverse effects. The use of celecoxib or omega-3 in schizophrenia may have beneficial effects. This study aimed to evaluate the possible efficacies of celecoxib, omega-3 or the combination of celecoxib+risperidone and omega-3+ risperidone compared to risperidone on the behavior and brain biochemistry in rats...
August 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27409727/relationships-between-serum-brain-derived-neurotrophic-factor-plasma-catecholamine-metabolites-cytokines-cognitive-function-and-clinical-symptoms-in-japanese-patients-with-chronic-schizophrenia-treated-with-atypical-antipsychotic-monotherapy
#6
Hikaru Hori, Reiji Yoshimura, Asuka Katsuki, Kiyokazu Atake, Ryohei Igata, Yuki Konishi, Jun Nakamura
OBJECTIVES: Catecholamines, brain-derived neurotrophic factor (BDNF) and cytokines may be involved in the pathophysiology of schizophrenia. The aim of this study was to examine the associations between serum BDNF levels, plasma catecholamine metablolites, cytokines and the cognitive functions of patients with schizophrenia treated with atypical antipsychotic monotherapy. METHODS: One hundred and forty-six patients with schizophrenia and 51 age- and sex-matched healthy controls were examined for peripheral biological markers and neurocognitive test...
July 13, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27337797/-analysis-of-the-changes-of-serum-high-mobility-group-protein-b1-and-cytokines-in-first-episode-schizophrenia-patients
#7
Qiyu Zhu, Xue Li, Gangrui Hie, Xiuxia Yuan, Luxian Lü, Xueqin Song
OBJECTIVE: To measure serum levels of high mobility group protein B-1 (HMGB1), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α ( TNF-α) before and after antipsychotic treatment, and further study the role of HMGB1 in schizophrenics. METHODS: Thirty first-episode schizophrenics who were never treated with neuroleptics from First Affiliated Hospital of Zhengzhou University and thirty healthy subjects were enrolled. Serum levels of cytokines such as HMGB1, IL-1β, IL-6 and TNF-α were examined with enzyme linked immunosorbent assay (ELISA) before and after antipsychotic treatment...
December 15, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27233514/the-atypical-antipsychotic-paliperidone-regulates-endogenous-antioxidant-anti-inflammatory-pathways-in-rat-models-of-acute-and-chronic-restraint-stress
#8
Karina S MacDowell, Javier R Caso, David Martín-Hernández, Beatriz M Moreno, José L M Madrigal, Juan A Micó, Juan C Leza, Borja García-Bueno
Alterations in the innate inflammatory response may underlie the pathophysiology of psychiatric diseases. Current antipsychotics modulate pro-/anti-inflammatory pathways, but their specific actions on these pathways remain only partly explored. This study was conducted to elucidate the regulatory role of paliperidone (1 mg/kg i.p.) on acute (6 h) and chronic (6 h/day for 21 consecutive days) restraint stress-induced alterations in 2 emerging endogenous anti-inflammatory/antioxidant mechanisms: nuclear factor erythroid-related factor 2 (NRF2)/antioxidant enzymes pathway, and the cytokine milieu regulating M1/M2 polarization in microglia, analyzed at the mRNA and protein levels in prefrontal cortex samples...
October 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/27230882/alteration-of-cytokines-levels-in-the-striatum-of-rats-possible-participation-in-vacuous-chewing-movements-induced-by-antipsycotics
#9
Luis Ricardo Peroza, Larissa Finger Schaffer, Catiuscia Molz De Freitas, Caroline Queiroz Leal, Mayara Calegaro Ferrari, Marta Maria Frescura Duarte, Roselei Fachinetto
Antipsychotic drugs have been used in the treatment of schizophrenia and their long-term use can cause movement disorders, such as tardive dyskinesia (TD) in humans mainly typical ones such as haloperidol. Neuroinflammation has been implicated to the use of antipsychotics besides its participation in TD remains unclear. Thus, the aim of this study was to investigate the relation of cytokines with vacuous chewing movements (VCMs) in rats comparing typical and atypical antipsychotics. Rats were treated with haloperidol or risperidone for 28 days...
September 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27177030/pro-inflammatory-cytokines-and-their-epistatic-interactions-in-genetic-susceptibility-to-schizophrenia
#10
Lekshmy Srinivas, Neetha N Vellichirammal, Ann Mary Alex, Chandrasekharan Nair, Indu V Nair, Moinak Banerjee
BACKGROUND: In schizophrenia, genetic background may provide a substrate for intrinsic maldevelopment of the brain through environmental influences, by recruiting neurotrophic factors and cytokines, to trigger the changes that lead to impaired neuronal functions. Cytokines being the key regulators of immune/inflammatory reactions are also known to influence the dopaminergic, noradrenergic, and serotonergic neurotransmission. Therefore, functional polymorphisms in cytokine genes may result in imbalances in the pro- and anti-inflammatory cytokine production...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27114618/cytokines-in-schizophrenia-hope-or-hype
#11
REVIEW
Maju Mathew Koola
Although there is a cumulative evidence for the inflammation pathophysiology in schizophrenia, it has not been conclusively proven yet. One reason for this is the lack of studies that have controlled for major confounding factors such as obesity, smoking, antipsychotic use, and stress. The studies in which the major confounding factors were controlled were done in subjects in acute relapse and in treatment-resistant schizophrenia. To date, no studies have been done in stable outpatients with schizophrenia controlling for major confounding factors...
March 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/27080462/protective-effects-of-quetiapine-on-metabolic-and-inflammatory-abnormalities-in-schizophrenic-patients-during-exacerbated-stage
#12
Yu-Chen Kao, Chih-Yuan Ko, Sheng-Chiang Wang, Yia-Ping Liu
Inflammation has been considered important in the pathogenesis of schizophrenia. Increasing evidence reveals that patients with schizophrenia have abnormal expression of cytokines, which are related to development of metabolic abnormalities. Metabolic abnormality has become a critical issue, though its longitudinal relationship with the disorder, such as the antipsychotics influence, is unclear. We aimed to investigate whether abnormalities of metabolic parameters and cytokine levels in acute exacerbated schizophrenic patients existed, and whether intervention of antipsychotic could help...
April 30, 2016: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/27073741/repurposing-psychiatric-medicines-to-target-activated-microglia-in-anxious-mild-cognitive-impairment-and-early-parkinson-s-disease
#13
REVIEW
Edward C Lauterbach
Anxiety is common in the Mild Cognitive Impairment (MCI) stage of Alzheimer's disease (AD) and the pre-motor stages of Parkinson's disease (PD). A concomitant and possible cause of this anxiety is microglial activation, also considered a key promoter of neurodegeneration in MCI and early PD via inflammatory mechanisms and the generation of degenerative proinflammatory cytokines. Psychiatric disorders, prevalent in AD and PD, are often treated with psychiatric drugs (psychotropics), raising the question of whether psychotropics might therapeutically affect microglial activation, MCI, and PD...
2016: American Journal of Neurodegenerative Disease
https://www.readbyqxmd.com/read/27057406/disequilibrium-of-cytokine-serum-levels-in-veterans-with-chronic-schizophrenia-medicated-with-antipsychotics-association-with-measures-of-excitement-and-hostility
#14
Dimitre H Dimitrov, Shuko Lee, Jesse Yantis, Craig Honaker, Roberta Coelho, Nicole Braida, Consuelo Walss-Bass
No abstract text is available yet for this article.
2015: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/26994434/cytokines-brain-derived-neurotrophic-factor-and-c-reactive-protein-in-bipolar-i-disorder-results-from-a-prospective-study
#15
Anne Sophie Jacoby, Klaus Munkholm, Maj Vinberg, Bente Klarlund Pedersen, Lars Vedel Kessing
BACKGROUND: Peripheral blood brain-derived neurotrophic factor (BDNF) and inflammatory markers may reflect key pathophysiological mechanisms in bipolar disorder in relation to disease activity and neuroprogression. AIMS: To investigate whether neutrophins and inflammatory marker vary with mood states and are increased in patients with bipolar disorder type I during euthymia as well as in all affective states as a group, compared to levels in healthy control subjects...
June 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/26712377/beneficial-effects-of-lycopene-against-haloperidol-induced-orofacial-dyskinesia-in-rats-possible-neurotransmitters-and-neuroinflammation-modulation
#16
Swati Datta, Sumit Jamwal, Rahul Deshmukh, Puneet Kumar
Tardive Dyskinesia is a severe side effect of chronic neuroleptic treatment consisting of abnormal involuntary movements, characterized by orofacial dyskinesia. The study was designed to investigate the protective effect of lycopene against haloperidol induced orofacial dyskinesia possibly by neurochemical and neuroinflammatory modulation in rats. Rats were administered with haloperidol (1mg/kg, i.p for 21 days) to induce orofacial dyskinesia. Lycopene (5 and 10mg/kg, p.o) was given daily 1hour before haloperidol treatment for 21 days...
January 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/26710531/-influence-of-adamantilbromphenylamine-on-parameters-of-immunity-and-symptoms-of-asthenia-in-patients-with-non-psychotic-mental-disorders
#17
T P Vetlugina, V B Nikitina, S A Sergeeva, M M Axenov, O A Lobacheva, D N Savochkina, E M Epanchintseva, N A Bokhan
OBJECTIVE: Our aim was to assess effect of antiasthenic drug adamantilbromphenylamine on the immune system and symptoms of asthenia in patients with non-psychotic mental disorders and to reveal possible criteria for prediction of treatment efficiency. METHODS: Uncontrolled study with interrupted time series was carried out. According to efficiency of treatment patients were divided into two groups (group 1 (n=21)--very much improved and much improved; group 2 (n=9)--minimally improved)...
2015: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
https://www.readbyqxmd.com/read/26690116/the-historical-development-of-immunoendocrine-concepts-of-psychiatric-disorders-and-their-therapy
#18
REVIEW
Holger Steinberg, Kenneth C Kirkby, Hubertus Himmerich
Relationships between the central nervous, immune and endocrine systems are a focus of psychiatric research, particularly in depression and schizophrenia. The field has long antecedents. Observed phenomena attributable to these relationships date back to the Neolithic era. Immunoendocrine theories in the broadest sense are recorded in antiquity. In the 19th century, Kraepelin and Wagner-Jauregg reported pioneering clinical observations in psychiatric patients. Von Basedow, Addison and Cushing described psychiatric symptoms in patients suffering from endocrine diseases...
2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26539073/the-role-of-inflammation-in-schizophrenia
#19
REVIEW
Norbert Müller, Elif Weidinger, Bianka Leitner, Markus J Schwarz
High levels of pro-inflammatory substances such as cytokines have been described in the blood and cerebrospinal fluid of schizophrenia patients. Animal models of schizophrenia show that under certain conditions an immune disturbance during early life, such as an infection-triggered immune activation, might trigger lifelong increased immune reactivity. A large epidemiological study clearly demonstrated that severe infections and autoimmune disorders are risk factors for schizophrenia. Genetic studies have shown a strong signal for schizophrenia on chromosome 6p22...
2015: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/26535964/stress-induced-anhedonia-is-associated-with-the-activation-of-the-inflammatory-system-in-the-rat-brain-restorative-effect-of-pharmacological-intervention
#20
Andrea C Rossetti, Mariusz Papp, Piotr Gruca, Maria Serena Paladini, Giorgio Racagni, Marco A Riva, Raffaella Molteni
Major depression is a complex disease that originates from the interaction between a genetic background of susceptibility and environmental factors such as stress. At molecular level, it is characterized by dysfunctions of multiple systems including neurotransmitters, hormones, signalling pathways, neurotrophic and neuroplastic molecules and - more recently - inflammatory mediators. Accordingly, in the present study we used the chronic mild stress (CMS) paradigm in the rat to elucidate to what extent brain inflammation may contribute to the development and/or the maintenance of an anhedonic phenotype and how pharmacological intervention may interfere with such behavioral and molecular stress-induced alterations...
January 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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