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https://www.readbyqxmd.com/read/29305329/increased-serum-levels-and-promoter-polymorphisms-of-macrophage-migration-inhibitory-factor-in-schizophrenia
#1
Satoshi Okazaki, Akitoyo Hishimoto, Ikuo Otsuka, Yuichiro Watanabe, Shusuke Numata, Shuken Boku, Naofumi Shimmyo, Makoto Kinoshita, Emiko Inoue, Tetsuro Ohmori, Toshiyuki Someya, Ichiro Sora
BACKGROUND: Numerous studies have suggested that an immune system imbalance plays an important role in schizophrenia. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine. It plays multiple roles in various biological processes, including inflammation and neurogenesis. Furthermore, several exhaustive serum proteomic profiling studies have identified MIF as a potential biomarker of schizophrenia. Here, we investigate MIF protein levels in serum and postmortem prefrontal cortex in patients with schizophrenia and controls...
January 2, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29283065/we-are-not-alone-in-our-body-insights-into-the-involvement-of-microbiota-in-the-etiopathogenesis-and-pharmacology-of-mental-illness
#2
Claudia Pisanu, Alessio Squassina
BACKGROUND: The etiopathogenesis of psychiatric disorders is still not completely understood. Growing evidence supports the hypothesis that mental illness and related disturbances in the brain neurobiology do not necessarily originate in the brain. Inflammation has been suggested to play a central role in psychiatric disorders, and altered levels of peripheral cytokines have been reported in several studies. OBJECTIVE AND METHODS: In this review, we present and discuss studies exploring the role of dysbiosis and products of the gut-microbiota in the pathogenesis of psychiatric disorders, as well as its potential involvement in mediating the effect of antidepressants, mood stabilizers, and antipsychotics...
December 27, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29276352/pretreatment-serum-mcp-1-level-predicts-response-to-risperidone-in-schizophrenia
#3
Yezhe Lin, Yanmin Peng, Cuizhen Zhu, Yousong Su, Yuan Shi, Zhiguang Lin, Jinghong Chen, Donghong Cui
Background: Schizophrenia is a chronic debilitating disease. The pathogenesis and treatment may be associated with inflammatory cytokines. There are few studies focusing on the prediction of cytokines in response to antipsychotics. Aim: To investigate whether cytokines would predict response to antipsychotics. Methods: Cross-sectional and natural observational cohort studies were applied to:(1) compare the baseline levels of serum IL-1β, TNF-α and MCP-1 between schizophrenia (n=64) and healthy controls (n=53); (2) To investigate the impact of baseline cytokines to psychopathology following olanzapine and risperidone monotherapy...
October 25, 2017: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29195684/mice-lacking-interleukin-18-gene-display-behavioral-changes-in-animal-models-of-psychiatric-disorders-possible-involvement-of-immunological-mechanisms
#4
S F Lisboa, A C Issy, C Biojone, K Montezuma, V Fattori, E A Del-Bel, F S Guimarães, F Q Cunha, W A Verri, S R L Joca
Preclinical and clinical evidence suggests pro-inflammatory cytokines might play an important role in the neurobiology of schizophrenia and stress-related psychiatric disorders. Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines and it is widely expressed in brain regions involved in emotional regulation. Since IL-18 involvement in the neurobiology of mental illnesses, including schizophrenia, remains unknown, this work aimed at investigating the behavior of IL-18 null mice (KO) in different preclinical models: 1...
November 10, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29143952/-the-effect-of-mood-stabilising-drugs-on-cytokine-levels-in-bipolar-disorder-a-systematic-review
#5
S Van Den Ameele, L van Diermen, W Staels, V Coppens, G Dumont, B Sabbe, M Morrens
Veranderde cytokineconcentraties bij personen met een bipolaire stoornis ten opzichte van controle-personen suggereren een rol van het immuunsysteem in de pathofysiologie van bipolaire stoornis. Farmacotherapie is een belangrijke verstorende factor in klinisch onderzoek naar cytokineconcentraties.<br/> DOEL: Evalueren van cytokineconcentraties bij medicatievrije patiënten met een bipolaire stoornis en van het effect van stemmingsstabiliserende geneesmiddelen op deze concentraties.<br/> METHODE: We doorzochten systematisch PubMed en Embase naar klinische studies die cytokineconcentraties bij medicatievrije patiënten met een bipolaire stoornis beschrijven of het effect van een individueel stemmingsstabiliserend geneesmiddel op deze concentraties evalueren...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29103822/ziprasidone-a-second-generation-antipsychotic-drug-triggers-a-macrophage-inflammatory-response-in-vitro
#6
Thiago Duarte, Fernanda Barbisan, Pedro Antônio Schmidt do Prado-Lima, Verônica Farina Azzolin, Ivo Emílio da Cruz Jung, Marta Maria Medeiros Frescura Duarte, Cibele Ferreira Teixeira, Moises Henrique Mastella, Ivana Beatrice Mânica da Cruz
Antipsychotic drugs are used to treat schizophrenia and other psychiatric disorders. However, most of these drugs present side effects causing obesity and other serious metabolic alterations that correlate with grade of chronic inflammation. In contrast, ziprasidone's (ZIP) metabolic side effects are attenuated relative to those of other antipsychotic drugs, but some reports suggest that this drug could cause allergic, hypersensitive reactions in susceptible patients. At present, the mechanism of ZIP's effect on peripheral inflammatory metabolism is not well characterized...
November 2, 2017: Cytokine
https://www.readbyqxmd.com/read/29020988/haloperidol-affects-bones-while-clozapine-alters-metabolic-parameters-sex-specific-effects-in-rats-perinatally-treated-with-phencyclidine
#7
Tatjana Nikolić, Milan Petronijević, Jelena Sopta, Milica Velimirović, Tihomir Stojković, Gordana Jevtić Dožudić, Milan Aksić, Nevena V Radonjić, Nataša Petronijević
BACKGROUND: The presentation of schizophrenia (SCH) symptoms differs between the sexes. Long-term treatment with antipsychotics is frequently associated with decreased bone mineral density, increased fracture risk and metabolic side effects. Perinatal phencyclidine (PCP) administration to rodents represents an animal model of SCH. The aim of this study was to assess the effects of chronic haloperidol and clozapine treatment on bone mass, body composition, corticosterone, IL-6 and TNF-α concentrations and metabolic parameters in male and female rats perinatally treated with PCP...
October 11, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28942956/long-non-coding-and-endogenous-retroviral-rna-levels-are-associated-with-proinflammatory-cytokine-mrna-expression-in-peripheral-blood-cells-implications-for-schizophrenia
#8
Jennifer K Melbourne, Kayla A Chase, Benjamin Feiner, Cherise Rosen, Rajiv P Sharma
Recent research indicates that the expression of long non-coding and endogenous retroviral RNAs is coordinated with the activity of immune molecules often dysregulated in schizophrenia. We measured the expression of TMEVPG1, NRON, HERV-W env and HERV-W gag in blood cells from participants with schizophrenia and controls. We report that a) expression levels of these non-coding RNAs are correlated with proinflammatory cytokine mRNA expression in all participants, b) HERV-W transcripts are negatively correlated with atypical antipsychotic use in participants with schizophrenia, and c) that these RNAs are transcribed in response to proinflammatory stimuli in a THP-1 monocyte cell line...
September 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28911850/activation-of-indoleamine-2-3-dioxygenase-pathway-by-olanzapine-augments-antidepressant-effects-of-venlafaxine-in-mice
#9
Jaya Thomas, Razia Khanam, Divya Vohora
Recent clinical studies report antipsychotics as a better option to augment the action of antidepressants in treatment resistant cases. However, the proper mechanisms underlying the antidepressant effect of antipsychotics is still not clear. Indolamine 2, 3 dioxygenase (IDO) pathway is considered to be an important pathway in pro-inflammatory cytokine associated stress-induced depression. The present study investigated the antidepressant effect of venlafaxine, olanzapine and their combinations in chronic forced-swim stress-induced depression in mice...
December 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28845163/neuroprotection-in-schizophrenia-and-its-therapeutic-implications
#10
REVIEW
Yong-Ku Kim, Kyoung-Sae Na
Schizophrenia is a chronic and debilitating mental disorder. The persisting negative and cognitive symptoms that are unresponsive to pharmacotherapy reveal the impairment of neuroprotective aspects of schizophrenia. In this review, of the several neuroprotective factors, we mainly focused on neuroinflammation, neurogenesis, and oxidative stress. We conducted a narrative and selective review. Neuroinflammation is mainly mediated by pro-inflammatory cytokines and microglia. Unlike peripheral inflammatory responses, neuroinflammation has a role in various neuronal activities such as neurotransmission neurogenesis...
July 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28694772/connexin-dependent-neuroglial-networking-as-a-new-therapeutic-target
#11
REVIEW
Mathieu Charvériat, Christian C Naus, Luc Leybaert, Juan C Sáez, Christian Giaume
Astrocytes and neurons dynamically interact during physiological processes, and it is now widely accepted that they are both organized in plastic and tightly regulated networks. Astrocytes are connected through connexin-based gap junction channels, with brain region specificities, and those networks modulate neuronal activities, such as those involved in sleep-wake cycle, cognitive, or sensory functions. Additionally, astrocyte domains have been involved in neurogenesis and neuronal differentiation during development; they participate in the "tripartite synapse" with both pre-synaptic and post-synaptic neurons by tuning down or up neuronal activities through the control of neuronal synaptic strength...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28688350/changes-in-the-cytokine-profile-in-first-episode-drug-na%C3%A3-ve-patients-with-psychosis-after-short-term-antipsychotic-treatment
#12
Petros Petrikis, Paraskevi V Voulgari, Alexandros T Tzallas, Vassiliki A Boumba, Dimitra T Archimandriti, Dimitrios Zambetas, Ioannis Papadopoulos, Ioannis Tsoulos, Petros Skapinakis, Venetsanos Mavreas
An increasing body of evidence suggests that antipsychotic medication can cause immunological changes that could be attributed to the amelioration of psychotic symptoms or the metabolic side effects of the drugs. So far, the results of the studies remain controversial. Our aim was to compare the levels of interleukin (IL) IL-2, IL-6 and transforming growth factor-β2 (TGF-β2) in drug-naïve, first-episode patients with psychosis before and after six weeks of antipsychotic medication. Thirty-nine first-episode patients with psychosis were enrolled in the study...
October 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28607752/enhanced-disease-reduction-using-clozapine-an-atypical-antipsychotic-agent-and-glatiramer-acetate-combination-therapy-in-experimental-autoimmune-encephalomyelitis
#13
Laura K Green, Pirooz Zareie, Nikki Templeton, Robert A Keyzers, Bronwen Connor, Anne Camille La Flamme
BACKGROUND: Atypical antipsychotic agents (AAP) alleviate the symptoms of severe mental health disorders, such as schizophrenia, by antagonizing dopamine and serotonin receptors. Recently, AAP have also been shown to exhibit immunomodulatory properties in the central nervous system (CNS). OBJECTIVE: Building on research which demonstrated the ability of the AAP risperidone and clozapine to modify the disease course of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), we aimed to more fully investigate the potential of clozapine as a possible treatment for MS...
January 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28595931/aripiprazole-induced-adverse-metabolic-alterations-in-polyi-c-neurodevelopmental-model-of-schizophrenia-in-rats
#14
Katerina Horska, Jana Ruda-Kucerova, Eva Drazanova, Michal Karpisek, Regina Demlova, Tomas Kasparek, Hana Kotolova
Schizophrenia appears to be linked to higher incidence of metabolic syndrome even in the absence of antipsychotic treatment. Atypical antipsychotics substantially differ in their propensity to induce metabolic alterations. Aripiprazole is considered to represent an antipsychotic drug with low risk of metabolic syndrome development. The aim of this study was to evaluate metabolic phenotype of neurodevelopmental polyI:C rat model and assess metabolic effects of chronic aripiprazole treatment with regard to complex neuroendocrine regulations of energy homeostasis...
September 1, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28566947/immunological-aspects-of-the-treatment-of-depression-and-schizophrenia
#15
Norbert Müller
Schizophrenia and major depression (MD) have been associated with immune system dysfunction. One example of this is the altered level of cytokines-important inflammatory mediators-in blood, and a proinflammatory immune state has been described in some subgroups of patients. A knock to the immune system in early life might trigger a life-long increased immune reactivity, and infections and autoimmune disorders are now known to be risk factors for development of schizophrenia and MD. Pro- and anti-inflammatory cytokines mediate indoleamine 2,3-dioxygenase activity; this enzyme drives metabolism of tryptophan and kynurenin in the central nervous system and degrades serotonin...
March 2017: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/28559638/a-case-of-olanzapine-induced-fever
#16
Cho-Hsiang Yang, Ying-Yeh Chen
Olanzapine, a frequently used second-generation antipsychotic, has rarely been implicated as a cause of drug-induced fever in the absence of neuroleptic malignant syndrome. We describe a patient who developed isolated fever following olanzapine monotherapy, which subsided after discontinuation of olanzapine. Blockade of dopaminergic receptors and elevated cytokines concentration are possible mechanisms of fever development during treatment with olanzapine. This case calls for attention to olanzapine-induced fever in clinical practice...
January 26, 2017: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/28453334/different-immune-signature-in-youths-experiencing-antipsychotic-induced-weight-gain-compared-to-untreated-obese-patients
#17
Simone Pisano, Gennaro Catone, Giangennaro Coppola, Marco Carotenuto, Raffaella Iuliano, Claudia Tiano, Anna Rita Montesanto, Vittoria D'Esposito, Emanuele Miraglia Del Giudice, Pietro Formisano, Carmela Bravaccio
OBJECTIVES: To assess cytokine and chemokine levels in youth experiencing antipsychotic-induced weight gain (AIWG) compared to obese patients, hypothesizing a different "immune signature" between the two kinds of obesity. METHODS: We compared a group of youth experiencing AIWG (N 19, mean age 159 months, mean body mass index [BMI] z-score 1.81) and an age-, gender-, and BMI-matched group of untreated obese patients (N 19, mean age 147 months, mean BMI z-score 2) for a wide range of cytokines and chemokines by using a multiplex ELISA test...
November 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28449562/longer-telomere-length-of-t-lymphocytes-in-patients-with-early-and-chronic-psychosis
#18
Yin Cui, Vishwanath Vasudev Prabhu, Thong Ba Nguyen, Subramaniam Mohana Devi, Young-Chul Chung
Objective: To investigate pathological conditions that act as sources of pro-inflammatory cytokines and cytotoxic substances to examine telomere length (TL) in patients with either early (duration of illness [DI] ≤5 years) or chronic (DI >5 years) psychosis using T lymphocytes. Methods: Based on these factors and the important role that T lymphocytes play in inflammation, the present study measured the TL of T lymphocytes in patients with either early or chronic psychosis...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28411046/different-influence-of-antipsychotics-on-the-balance-between-pro-and-anti-inflammatory-cytokines-depends-on-glia-activation-an-in-vitro-study
#19
Ewa Obuchowicz, Anna M Bielecka-Wajdman, Monika Paul-Samojedny, Marta Nowacka
The microglial hypothesis of schizophrenia suggests that its neuropathology is closely associated with neuroinflammation manifested, inter alia, by an increased expression of cytokines. However, clinical investigations imply that schizophrenia is a heterogeneous disease and in some groups of patients the activated inflammatory process does not contribute to the disease-associated impairment of brain function. Clinical studies revealed also an equivocal impact of antipsychotics on peripheral and CSF cytokines, whereas experimental research performed on the stimulated glia cultures showed their inhibitory effect on pro-inflammatory cytokine levels...
April 11, 2017: Cytokine
https://www.readbyqxmd.com/read/28374670/the-effect-of-ibuprofen-on-cytokine-production-by-mononuclear-cells-from-schizophrenic-patients
#20
H Bessler, D Cohen-Terica, M Djaldetti, P Sirota
The existence of a restrained inflammatory state in schizophrenic individuals posed the question whether anti-inflammatory drugs may exert antipsychotic effects. Therefore, the effect of ibuprofen (IB) on cytokine production by human peripheral blood mononuclear cells (PBMC) from schizophrenic patients was examined and compared to that of healthy subjects. PBMC from 25 schizophrenic patients and 24 healthy volunteers were incubated for 24 h with lipopolysaccharide (LPS) in the absence or presence of various concentrations of IB...
2017: Folia Biologica (Praha)
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