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https://www.readbyqxmd.com/read/29456899/facial-weakness-diplopia-and-fever-in-a-31-year-old-an-atypical-case-of-tuberculous-meningitis
#1
Ahmed H Qavi, Tasnim F Imran, Zachariah Hasan, Fariha Ilyas
Tuberculous meningitis (TBM) is an infection of the central nervous system (CNS) meninges that carries high morbidity and mortality. It is important to recognize, as patients may present with atypical symptoms. We describe the case of a 31-year-old man with a history of diabetes who presented with a sub-acute onset of right-sided facial weakness and right gaze difficulty with diplopia. History revealed low-grade fever, right-sided headache, fatigue and moderate weight loss for the past several weeks. The patient did not report neck stiffness, rigidity, fever, chills or cough...
December 7, 2017: Curēus
https://www.readbyqxmd.com/read/29456444/pain-pattern-classification-and-directional-preference-are-associated-with-clinical-outcomes-for-patients-with-low-back-pain
#2
Richard Yarznbowicz, Minjing Tao, Alexa Owens, Matt Wlodarski, Jonathan Dolutan
Pain Pattern Classification (PPC) and Directional Preference (DP) have shown merit as reliable and predictable clinical solutions to help reduce the burden posed by low back pain (LBP). We conducted a prospective, observational cohort study to verify the association between PPC, DP, and clinical outcomes. We hypothesized that (1) patients who demonstrated DP Centralization (CEN) would have lower pain intensity and disability at follow-up than patients who demonstrated Non-DP Non-CEN, and (2) the prevalence of DP at first examination would be lowest for patients with chronic LBP and are greater than 65 years old...
February 2018: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/29454958/clinical-features-and-surgical-management-of-cerebellopontine-angle-cholesteatoma-presented-as-trigeminal-neuralgia
#3
Ma Kai, Li Yongjie
BACKGROUND: It is difficult to differentiate patients with cerebellopontine angle (CPA) cholesteatoma and patients with primary trigeminal neuralgia(TN) just according to early symptoms. We aimed to explore the clinical characteristics, early diagnosis and microneurosurgical techniques for CPA cholesteatoma presented as trigeminal neuralgia. METHODS: The data of 26 patients who complained trigeminal neuralgia with cerebellopontine angle cholesteatoma between January 2009 and December 2015 were collected and studied retrospectively, they were diagnosed by MRI preoperatively and confirmed by pathology postoperatively...
February 15, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29454383/multidimensional-needs-of-patients-living-and-dying-with-heart-failure-in-kenya-a-serial-interview-study
#4
Kellen N Kimani, Scott A Murray, Liz Grant
BACKGROUND: Heart failure is an emerging challenge for Sub Saharan Africa. However, research on patients' needs and experiences of care is scarce with little evidence available to support and develop services. We aimed to explore the experiences of patients living and dying with heart failure in Kenya. METHODS: We purposively recruited 18 patients admitted with advanced heart failure at a rural district hospital in Kenya. We conducted serial in depth interviews with patients at 0, 3 and 6 months after recruitment, and conducted bereavement interviews with carers...
February 17, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29454129/delayed-post-traumatic-subacute-lumbar-subarachnoid-hematoma-case-report-and-review-of-the-literature
#5
Thiébaud Picart, Timothée Jacquesson, Emmanuel Jouanneau, Moncef Berhouma
BACKGROUND: Traumatic spinal subarachnoid hematoma, associated or not to a concurrent subdural hematoma has rarely been described. The evolution of such hematomas is heterogeneous. This study aims at defining the most accurate management which is currently not standardized. CASE DESCRIPTION: A 20-year-old man, victim of a high kinetic road accident five days before, suffering from several non-neurologic non-surgical vertebral fractures, complained of a sudden dorso-lumbar pain irradiating to his lower limbs...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29453980/virtual-reality-for-upper-limb-rehabilitation-in-sub-acute-and-chronic-stroke-a-randomized-controlled-trial
#6
Pawel Kiper, Andrzej Szczudlik, Michela Agostini, Jozef Opara, Roman Nowobilski, Laura Ventura, Paolo Tonin, Andrea Turolla
OBJECTIVE: To evaluate the effectiveness of reinforced feedback in virtual environment (RFVE) treatment combined with conventional rehabilitation (CR) in comparison with CR alone, and to study whether changes are related to stroke aetiology (i.e. ischemic or hemorrhagic). DESIGN: Randomized controlled trial. SETTING: Inpatients in a hospital facility for intensive rehabilitation. PARTICIPANTS: 136 patients within one year from onset of a single stroke...
February 14, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29453795/inflammatory-and-degenerative-phases-resulting-from-anterior-cruciate-rupture-in-a-non-invasive-murine-model-of-post-traumatic-osteoarthritis
#7
Sophie Jane Gilbert, Cleo Selina Bonnet, Paulina Stadnik, Victor Colin Duance, Deborah JaneMason, Emma Jane Blain
Joint injury is the predominant risk factor for post-traumatic osteoarthritis development (PTOA). Several non-invasive mouse models mimicking human PTOA investigate molecular mechanisms of disease development; none have characterised the inflammatory response to this acute traumatic injury. Our aim was to characterise the early inflammatory phase and later degenerative component in our in vivo non-invasive murine model of PTOA induced by anterior cruciate ligament (ACL) rupture. Right knees of 12-week-old C57Bl6 mice were placed in flexion at a 30° offset position and subjected to a single compressive load (12N, 1...
February 17, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29453170/symmetry-of-cortical-planning-for-initiating-stepping-in-sub-acute-stroke
#8
Sue Peters, Tanya D Ivanova, Bimal Lakhani, Lara A Boyd, W Richard Staines, Todd C Handy, S Jayne Garland
OBJECTIVE: This study examined motor planning for stepping when the paretic leg was either stepping or standing (to step with the non-paretic leg), to understand whether difficulty with balance and walking post-stroke could be attributed to poor motor planning. METHODS: Individuals with stroke performed self-initiated stepping. Amplitude and duration of the movement-related cortical potential (MRCP) was measured from Cz. Electromyography (EMG) of biceps femoris (BF) and rectus femoris (RF) were collected...
February 1, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29452400/sleep-quality-in-well-defined-lyme-disease-a-clinical-cohort-study-in-maryland
#9
Eric R Weinstein, Alison W Rebman, John N Aucott, Doug Johnson-Greene, Kathleen T Bechtold
Study Objectives: Lyme disease (LD) is the most common vector-borne disease in the United States. Approximately 5-15% of patients develop post-antibiotic treatment symptoms termed post-treatment LD syndrome (PTLDS). The primary objective of this study was to examine and quantify sleep quality among patients with early Lyme disease during the acute and convalescent periods, including among the subset who met criteria for PTLDS. Methods: This paper draws from a clinical cohort study of early LD participants (n=122) and a sub-cohort of individuals who later met criteria for PTLDS (n=6)...
February 14, 2018: Sleep
https://www.readbyqxmd.com/read/29449129/sub-minimum-inhibitory-concentrations-of-ceftazidime-inhibit-pseudomonas-aeruginosa-biofilm-formation
#10
Satoshi Otani, Kazufumi Hiramatsu, Kazuhiko Hashinaga, Kosaku Komiya, Kenji Umeki, Kenji Kishi, Jun-Ichi Kadota
Pseudomonas aeruginosa exhibits the biofilm mode of growth and causes chronic as well as acute infections in humans. Several reports have shown that the treatments with sub-minimum inhibitory concentrations (sub-MICs) of antimicrobial agents influence biofilm formation by P. aeruginosa. The antibiotic ceftazidime (CAZ) is used to treat P. aeruginosa infections, but few studies have examined the effects of β-lactams on biofilm formation by P. aeruginosa. In this study, we investigated the role of sub-MICs of CAZ in the formation of P...
February 12, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29441005/atypical-within-session-motor-procedural-learning-after-traumatic-brain-injury-but-well-preserved-between-session-procedural-memory-consolidation
#11
Maria Korman, Sharon Shaklai, Keren Cisamariu, Carmit Gal, Rinatia Maaravi-Hesseg, Ishay Levy, Ofer Keren, Avi Karni, Yaron Sacher
Using the finger-to-thumb opposition sequence (FOS) learning task, we characterized motor skill learning in sub-acute patients hospitalized for rehabilitation following traumatic brain injury (TBI). Ten patients (Trained TBI) and 11 healthy participants (Trained Healthy) were trained using a multi-session protocol: a single session was afforded in the first week of the study, and four daily sessions were afforded during the second week. Intensity of practice was adapted to patients. Performance speed and accuracy were tested before and after each session...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29438746/longitudinal-changes-in-mr-t1%C3%AF-t2-signal-of-meniscus-and-its-association-with-cartilage-t1p-t2-in-acl-injured-patients
#12
Joseph Knox, Valentina Pedoia, Amy Wang, Matthew Tanaka, Gabby B Joseph, Jan Neumann, Thomas M Link, Xiaojuan Li, C Benjamin Ma
OBJECTIVE: To evaluate the longitudinal changes in meniscal T1ρ/T2 signal post-reconstruction in patients with acute anterior cruciate ligament (ACL) injury and to investigate the association with T1ρ/T2 signal in articular knee cartilage. METHOD: In this prospective study, knees of 37 patients with ACL-injury and reconstruction in addition to 13 healthy controls were scanned using magnetic resonance imaging (MRI) T1ρ/T2 mapping. Quantitative analysis of the meniscus was performed in the anterior/posterior horns of lateral/medial meniscus fourteen sub-compartments of cartilage spanning the medial/lateral area of the tibia and femoral condyles...
February 10, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29436397/impacts-of-an-opioid-overdose-prevention-intervention-delivered-subsequent-to-acute-care
#13
Caleb J Banta-Green, Phillip O Coffin, Joseph O Merrill, Jeanne M Sears, Chris Dunn, Anthony S Floyd, Lauren K Whiteside, Norbert D Yanez, Dennis M Donovan
BACKGROUND: Opioid overdose is a major and increasing cause of injury and death. There is an urgent need for interventions to reduce overdose events among high-risk persons. METHODS: Adults at elevated risk for opioid overdose involving heroin or pharmaceutical opioids who had been cared for in an emergency department (ED) were randomised to overdose education combined with a brief behavioural intervention and take-home naloxone or usual care. Outcomes included: (1) time to first opioid overdose-related event resulting in medical attention or death using competing risks survival analysis; and (2) ED visit and hospitalisation rates, using negative binomial regression and adjusting for time at risk...
February 7, 2018: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/29435691/common-data-elements-collected-among-universities-for-sport-related-concussion-studies
#14
Jingzhen Yang, Corinne Peek-Asa, James M Noble, James Torner, Paul Schmidt, Martha L Cooper
BACKGROUND: Universities are increasingly implementing programs to effectively respond to and manage sport-related concussions (SRCs). One such effort is to develop common data elements (CDEs) and standardize data collection methods. The objectives of this study were to describe CDEs currently collected by Big Ten and Ivy League universities for SRC studies, and to compare the data collected with the core CDEs recommended by the National Institute of Neurological Disorders and Stroke (NINDS)...
February 12, 2018: Injury Epidemiology
https://www.readbyqxmd.com/read/29434186/preconditioning-induced-by-sub-toxic-dose-of-the-neurotoxin-l-bmaa-delays-als-progression-in-mice-and-prevents-na-ca2-exchanger-3-downregulation
#15
Serenella Anzilotti, Paola Brancaccio, Giuseppe Simeone, Valeria Valsecchi, Antonio Vinciguerra, Agnese Secondo, Tiziana Petrozziello, Natascia Guida, Rossana Sirabella, Ornella Cuomo, Pasquale Cepparulo, Andrè Herchuelz, Salvatore Amoroso, Gianfranco Di Renzo, Lucio Annunziato, Giuseppe Pignataro
Preconditioning (PC) is a phenomenon wherein a mild insult induces resistance to a later, severe injury. Although PC has been extensively studied in several neurological disorders, no studies have been performed in amyotrophic lateral sclerosis (ALS). Here we hypothesize that a sub-toxic acute exposure to the cycad neurotoxin beta-methylamino-L-alanine (L-BMAA) is able to delay ALS progression in SOD1 G93A mice and that NCX3, a membrane transporter able to handle the deregulation of ionic homeostasis occurring during ALS, takes part to this neuroprotective effect...
February 12, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29433180/atlantoaxial-fixation-for-odontoid-fracture-analysis-of-124-surgically-treated-cases
#16
Atul Goel, Sonal Jain, Abhidha Shah, Abhinandan Patil, Ravikiran Vutha, Shashi Ranjan, Sandeep More
OBJECTIVE: The authors analyze 124 cases with fracture of odontoid process. All patients were surgically treated by posterior atlantoaxial fixation. METHODS: There were 96 male and 28 female patients. The ages of the patients ranged from 12 to 80 years. Apart from Anderson and D'Alonzo type I (6 cases), type II (93 cases) and type III (25 cases), three sub-types of odontoid fractures were included in the classification. In type A (118 cases), there was vertical compression fracture that resulted in malalignment of the fractured odontoid process segments...
February 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29432997/a-comparative-study-of-hand-hygiene-and-alcohol-based-hand-rub-use-among-irish-nursing-and-medical-students
#17
Liz M Kingston, Nuala H O'Connell, Colum P Dunne
BACKGROUND: In Ireland, the setting for this study, the national prevalence rate of health care-associated infection (HCAI) in acute-care facilities is 5.2%. Hand hygiene and in particular hand rubbing using alcohol-based hand rub (ABHR) is highly efficacious in preventing HCAI transmission. Yet, compliance among healthcare professionals is sub-optimal. Less is known about the practices of nursing and medical students and no study comparing practices among these groups in Ireland was found...
January 31, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29432666/impact-of-rotavirus-vaccination-on-rotavirus-hospitalization-rates-among-a-resource-limited-rural-population-in-mbita-western-kenya
#18
Ernest Apondi Wandera, Shah Mohammad, Martin Bundi, James Nyangao, Amina Galata, Cyrus Kathiiko, Erick Odoyo, Sora Guyo, Gabriel Miring'u, Satoshi Komoto, Yoshio Ichinose
OBJECTIVES: A two-dose oral monovalent rotavirus vaccine (RV1) was introduced into the Kenyan National Immunization Program in July 2014. We assessed trends in hospitalization for rotavirus-specific acute gastroenteritis (AGE) and strain distribution among children <5 years in a rural, resource-limited setting in Kenya before and after the nationwide implementation of the vaccine. METHODS: Data on rotavirus AGE and strain distribution were derived from a five-year hospital-based surveillance...
February 12, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29429439/clinical-characteristics-and-causes-of-heart-failure-adherence-to-treatment-guidelines-and-mortality-of-patients-with-acute-heart-failure-experience-at-groote-schuur-hospital-cape-town-south-africa
#19
P Z Szymanski, M Badri, B M Mayosi
BACKGROUND: There is limited information on acute heart failure (AHF) and its treatment in sub-Saharan Africa. OBJECTIVE: To describe the clinical characteristics and causes of heart failure (HF), adherence to HF treatment guidelines, and mortality of patients with AHF presenting to Groote Schuur Hospital (GSH), Cape Town, South Africa. METHODS: This sub-study of The Sub-Saharan Africa Survey of Heart Failure (THESUS-HF) was a prospective and observational survey that focused on the enrolment and follow-up of additional patients with AHF presenting to GSH and entered into the existing registry after publication of the primary THESUS-HF article in 2012...
February 1, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29429131/mortality-associated-with-bevacizumab-intravitreal-injections-in-age-related-macular-degeneration-patients-after-acute-myocardial-infarct-a-retrospective-population-based-survival-analysis
#20
Joel Hanhart, Doron S Comaneshter, Yossi Freier-Dror, Shlomo Vinker
BACKGROUND: Intraocular injections of antivascular endothelial growth factor (VEGF) agents are currently the main therapy in age-related macular degeneration (AMD). The safety of bevacizumab, an anti-VEGF compound frequently delivered off label, is debated, particularly for high-group risks. We aim to analyze the mortality associated with intravitreal injections of bevacizumab for AMD in patients previously diagnosed with acute myocardial infarct (MI). METHODS: In a national database, we identified bevacizumab-treated AMD patients with a diagnosis of MI prior to their first bevacizumab injection, delivered between September 2008 and October 2014 (n = 2100)...
February 10, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
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