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https://www.readbyqxmd.com/read/28333155/network-analysis-a-novel-method-for-mapping-neonatal-acute-transport-patterns-in-california
#1
S N Kunz, J A F Zupancic, J Rigdon, C S Phibbs, H C Lee, J B Gould, J Leskovec, J Profit
OBJECTIVE: The objectives of this study are to use network analysis to describe the pattern of neonatal transfers in California, to compare empirical sub-networks with established referral regions and to determine factors associated with transport outside the originating sub-network. STUDY DESIGN: This cross-sectional database study included 6546 infants <28 days old transported within California in 2012. After generating a graph representing acute transfers between hospitals (n=6696), we used community detection techniques to identify more tightly connected sub-networks...
March 23, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28331896/hematological-parameters-on-the-effect-of-the-jellyfish-venom-cassiopea-andromeda-in-animal-models
#2
Iraj Nabipour, Gholamhossein Mohebbi, Hossein Vatanpour, Amir Vazirizadeh
For the first time, we previously recorded an enormous population of the Cassiopea andromeda jellyfish that had increased dramatically from Bushehr coasts of Iran. The sub-acute toxicity of the jellyfish venom in rat organs was correspondingly carried out. The data presented in this paper relate to the in vivo and in vitro hematological effects of this venomous species of jellyfish venom.
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28330794/radiation-exposure-and-vascular-access-in-acute-coronary-syndromes-the-radmatrix-trial
#3
Alessandro Sciahbasi, Enrico Frigoli, Alessandro Sarandrea, Martina Rothenbühler, Paolo Calabrò, Alessandro Lupi, Francesco Tomassini, Bernardo Cortese, Stefano Rigattieri, Enrico Cerrato, Dennis Zavalloni, Antonio Zingarelli, Paolo Calabria, Paolo Rubartelli, Gennaro Sardella, Matteo Tebaldi, Stephan Windecker, Peter Jüni, Dik Heg, Marco Valgimigli
BACKGROUND: It remains unclear whether radial increases the risk of operator or patient radiation exposure when performed by expert operators OBJECTIVES: To determine whether radial access increases radiation exposure METHODS: We randomly assigned 8404 patients, with or without ST-segment elevation acute coronary syndrome, to radial or femoral access for coronary angiography and percutaneous intervention, and collected fluoroscopy time and dose area product (DAP). In the radiation sub-study (RAD-MATRIX), we anticipated that 13 or more operators, each wearing a thorax (primary endpoint), wrist and head (secondary endpoints) lithium fluoride thermo luminescent dosimeter and randomizing at least 13 patients per access site were needed to establish non-inferiority of radial versus femoral access...
March 15, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28325013/mirror-therapy-combined-with-functional-electrical-stimulation-for-rehabilitation-of-stroke-survivors-ankle-dorsiflexion
#4
Ghadir Salhab, Ahmad Rifaii Sarraj, Soha Saleh
This study investigates the effect of combining both mirror therapy with Electrical Stimulation (ES) on improvement of the function of lower extremity compared to conventional therapy. 18 stroke survivors (sub acute stage) were recruited, 9 of them were randomly assigned to receive conventional treatment and another 9 started the mirror therapy combined with ES treatment. Duration of each session in both interventions was 50 minutes, done 4 times per week over two weeks. After 2 weeks, subjects took one week rest before switching they type of treatment; those started with conventional therapy continued with mirror therapy combined with ES, and vice versa...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28322830/antidiabetic-antidyslipidemic-and-toxicity-profile-of-env-2-a-potent-pyrazole-derivative-against-diabetes-and-related-diseases
#5
Eduardo Hernández-Vázquez, Hugo Ocampo-Montalban, Litzia Cerón-Romero, Miguel Cruz, Jaime Gomez-Zamudio, Guadalupe Hiriart-Valencia, Rafael Villalobos-Molina, Angelica Flores-Flores, Samuel Estrada-Soto
Diabetes is a major health problem and a predisposition factor for further degenerative complications and, therefore, novel therapies are urgently needed. Currently, cannabinoid receptor 1 (CB1 receptor) antagonists have been considered as promissory entities for metabolic disorders treatment. Accordingly, the purpose of this work was the evaluation of the sub-acute antidiabetic, anti-hyperglycemic, antidyslipidemic and toxicological profile of ENV-2, a potent hypoglycemic and antioxidant CB1 receptor antagonist...
March 17, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28320719/antibiotic-effects-on-methicillin-resistant-staphylococcus-aureus-cytoplasmic-peptidoglycan-intermediate-levels-evidence-for-potential-metabolite-level-regulatory-loops
#6
Harika Vemula, Navid J Ayon, Alloch Burton, William G Gutheil
Cytoplasmic peptidoglycan (PG) precursor levels were determined in methicillin resistant S. aureus (MRSA) after exposure to several cell wall targeting antibiotics. Three experiments were performed: 1) Exposure to 4x MIC levels (acute). 2) Exposure to sub-MIC levels (sub-acute). 3) A time course of the effect of vancomycin. In acute exposure experiments, fosfomycin increased UDP-GlcNAc, as expected, and resulted in substantially lower levels of total UDP-linked metabolite accumulation relative to other pathway inhibitors, indicating reduced entry into this pathway...
March 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28320375/psychological-risk-and-protective-factors-for-disability-in-chronic-low-back-pain-a-longitudinal-analysis-in-primary-care
#7
Nikita Roman A Jegan, Markus Brugger, Annika Viniol, Konstantin Strauch, Jürgen Barth, Erika Baum, Corinna Leonhardt, Annette Becker
BACKGROUND: Utilizing psychological resources when dealing with chronic low back pain might aid the prevention of disability. The observational study at hand examined the longitudinal impact of resilience and coping resources on disability in addition to established risk factors. METHODS: Four hundred eighty four patients with chronic low back pain (>3 months) were recruited in primary care practices and followed up for one year. Resilience, coping, depression, somatization, pain and demographic variables were measured at baseline...
March 20, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28320124/the-p-wave-terminal-force-in-embolic-strokes-of-undetermined-source
#8
Simona Lattanzi, Claudia Cagnetti, Alessandra Pulcini, Marco Morelli, Simone Maffei, Leandro Provinciali, Mauro Silvestrini
BACKGROUND: The Embolic Stroke of Undetermined Source (ESUS) is a recently developed clinical construct which describes stroke patients for whom the embolic source remains undetermined despite recommended investigations. The aim of the study was to characterize the ESUS population according to the abnormality in the P-wave terminal force in lead V1 (PTFV1). METHODS: We retrospectively identified consecutive patients hospitalized for acute ischemic stroke who met the ESUS diagnostic criteria...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319789/group-schema-therapy-for-personality-disorders-a-pilot-study-for-implementation-in-acute-psychiatric-in-patient-settings
#9
Igor Nenadić, Sina Lamberth, Neele Reiss
Group schema therapy (GST) has been proposed as a novel long-term treatment programme for borderline and cluster C personality disorders. We implemented a short-term GST programme (12-15 sessions, based on the manual by Farrell and Shaw (2012), including both cognitive / behavioural and experiential interventions for in-patients (n=9) with either borderline or cluster C personality disorders (and axis I co-morbidities) treated in a (sub)acute psychiatric in-patient setting. We evaluated pre- and post-treatment self-report of maladaptive and adaptive schema modes (using the SMI) and early maladaptive schemas (YSQ-3), as well as overall symptom severity (brief symptom check list, BSCL-53-S), patient satisfaction (ZUF-8) and group climate and coherence (GCQ-S)...
February 3, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28317833/regulation-of-nf-%C3%AE%C2%BAb-by-pml-and-pml-rar%C3%AE
#10
Abrar Ahmed, Xiaochun Wan, Izaskun Mitxitorena, Andrew J Lindsay, Pier Paolo Pandolfi, Mary W McCaffrey, Karen Keeshan, Youhai H Chen, Ruaidhrí J Carmody
Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. PML is a tumour suppressor and regulator of cell differentiation. We demonstrate that PML promotes TNFα-induced transcriptional responses by promoting NF-κB activity. TNFα-treated PML(-/-) cells show normal IκBα degradation and NF-κB nuclear translocation but significantly reduced NF-κB DNA binding and phosphorylation of NF-κB p65. We also demonstrate that the PML retinoic acid receptor-α (PML-RARα) oncofusion protein, which causes acute promyelocytic leukemia, inhibits TNFα induced gene expression and phosphorylation of NF-κB...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317289/stroke-recurrence-in-patients-with-atrial-fibrillation-concomitant-carotid-artery-stenosis-doubles-the-risk
#11
H Lehtola, K E J Airaksinen, P Hartikainen, J E K Hartikainen, A Palomäki, I Nuotio, A Ylitalo, T Kiviniemi, P Mustonen
BACKGROUND AND PURPOSE: Atrial fibrillation (AF) and significant carotid artery stenosis (CAS) often coexist in patients with acute stroke but whether CAS affects the stroke recurrence rate in anticoagulated AF patients is largely unknown. The effect of concomitant CAS on both short- and long-term prognosis after stroke in patients with AF was evaluated. METHODS: The multicentre, retrospective FibStroke registry included AF patients with an ischaemic stroke or transient ischaemic attack (TIA) during 2003-2012...
March 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28315791/neurotoxic-effects-molecular-responses-and-oxidative-stress-biomarkers-in-nile-tilapia-oreochromis-niloticus-linnaeus-1758-exposed-to-verapamil
#12
Malachy N O Ajima, Pramod K Pandey, Kundan Kumar, Nalini Poojary
Pharmaceutical drugs and their metabolites are detected in aquatic ecosystems and have been reported to cause ecotoxicological consequences to resident aquatic organisms The study investigated the effects of acute and long-term exposure to verapamil on activities of acetylcholinesterase and antioxidant enzymes as well as mRNA expression of stress-related genes in brain and muscle tissues of Nile tilapia, Oreochromis niloticus. The 96h LC50 of verapamil to O. niloticus was 2.29mgL(-1). Exposure to sub-lethal concentrations of verapamil (0...
March 16, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28303410/downregulation-of-myogenic-micrornas-in-sub-chronic-but-not-in-sub-acute-model-of-daunorubicin-induced-cardiomyopathy
#13
Gabriel Doka, Eva Malikova, Kristina Galkova, Giampiero La Rocca, Peter Kruzliak, Mariusz Adamek, Luis Rodrigo, Peter Krenek, Jan Klimas
Cardiac muscle-related microRNAs play important roles in cardiac development and disease by translational silencing of mRNAs, the dominant mechanism of microRNA action. To test whether they could be involved in daunorubicin-associated cardiomyopathy (DACM), we determined expression patterns of myomiRs in two distinct models of DACM. We used 10-12 weeks old male Wistar rats. In the sub-acute model, rats were administered with six doses of daunorubicin (DAU-A, 3 mg/kg, i.p., every 48 h). Rats were sacrificed two days after the last dose...
March 16, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28302096/mathematical-analysis-of-a-lymphatic-filariasis-model-with-quarantine-and-treatment
#14
Peter M Mwamtobe, Simphiwe M Simelane, Shirley Abelman, Jean M Tchuenche
BACKGROUND: Lymphatic filariasis is a globally neglected tropical parasitic disease which affects individuals of all ages and leads to an altered lymphatic system and abnormal enlargement of body parts. METHODS: A mathematical model of lymphatic filariaris with intervention strategies is developed and analyzed. Control of infections is analyzed within the model through medical treatment of infected-acute individuals and quarantine of infected-chronic individuals...
March 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28300576/clinical-significance-of-spasmolytic-polypeptide-expressing-metaplasia-and-intestinal-metaplasia-in-ebv-associated-and-ebv-negative-gastric-cancer
#15
Yu Zhang, Jian-Ning Chen, Min Dong, Zhi-Gang Zhang, Yi-Wang Zhang, Jun-Yan Wu, Hong Du, Hai-Gang Li, Yan Huang, Chun-Kui Shao
Spasmolytic polypeptide-expressing metaplasia (SPEM) and intestinal metaplasia (IM) have been recognized as neoplastic precursors in gastric carcinogenesis. We explored the relationship between SPEM and IM in Epstein-Barr virus-associated (EBVaGC) and Epstein-Barr virus-negative (EBVnGC) gastric cancer. 64 EBVaGC and 154 EBVnGC patients were included. EBV-positivity was identified using EBER-1 in situ hybridization. SPEM was sub-classified into absent, early and advanced SPEM. Acute and chronic inflammation was graded as absent, mild, moderate and marked...
March 11, 2017: Human Pathology
https://www.readbyqxmd.com/read/28295931/salsalate-improves-glycemia-in-overweight-persons-with-diabetes-risk-factors-of-stable-statin-treated-cardiovascular-disease-a-30-month-randomized-placebo-controlled-trial
#16
Ninad Salastekar, Tanvi Desai, Thomas Hauser, Ernst J Schaefer, Kristen Fowler, Stacey Joseph, Steven Shoelson, Allison B Goldfine
Obesity related sub-acute chronic inflammation contributes to type 2 diabetes and atherosclerosis (1,2) . Multiple studies target inflammation to reduce dysglycemia and/or coronary heart disease (CHD) using diverse anti-inflammatory approaches. Several show salsalate, a pro-drug of salicylate, improves glycemia in type 2 diabetes, obesity, or impaired glucose tolerance. Durability of glycemic efficacy and safety of salsalate remains less well understood.
March 14, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28293386/toxicology-effects-of-saffron-and-its-constituents-a-review
#17
REVIEW
Hasan Badie Bostan, Soghra Mehri, Hossein Hosseinzadeh
Saffron (Crocus sativus L.) has been considered as a medicinal plant since ancient times and also widely used as food additive for its color, taste and odor. The pharmacological properties of saffron and its main constituents, crocin and safranal have been evaluated using different in vivo and in vitro models. Additionally, other lines of studies have found toxicological effects of saffron. However, a comprehensive review that covers all aspects of its toxicity has not been published yet. The current study provides classified information about the toxic effects of saffron and its constituents in various exposure conditions including acute, sub-acute, sub-chronic and chronic studies...
February 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28293224/prevalence-of-m75-streptococcus-pyogenes-strains-harboring-slaa-gene-in-patients-affected-by-pediatric-obstructive-sleep-apnea-syndrome-in-central-italy
#18
Elisa Viciani, Francesca Montagnani, Giacinta Tordini, Antonio Romano, Lorenzo Salerni, Andrea De Luca, Paolo Ruggiero, Andrea G O Manetti
Recently we reported an association between pediatric obstructive sleep apnea syndrome (OSAS) and Group A streptococcus (GAS) sub-acute chronic tonsil colonization. We showed that GAS may contribute to tonsil hyperplasia via a streptolysin O (SLO)-dependent cysteinyl leukotrienes (CysLTs) production, which can trigger T and B cell proliferation. In the present study, we characterized the GAS strains isolated from pediatric OSAS patients in comparison with a panel of age and sex matched GAS strains unrelated to OSAS, but isolated in the same area and during the same period ranging from 2009 to 2013...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28292684/meta-analytical-assessment-of-the-effects-of-protocol-variations-on-cortisol-responses-to-the-trier-social-stress-test
#19
REVIEW
William K Goodman, Johanna Janson, Jutta M Wolf
BACKGROUND: The Trier Social Stress Test (TSST) is one of the most widely used laboratory stress tests. Exposure to this psychosocial stressor has been shown to stimulate an acute cortisol stress response in the majority of healthy individuals, while deviations from the typical pattern, i.e., cortisol reactivity dysfunctions have been linked to an ever-increasing number of negative health outcomes. However, significant variability between labs exists in strength of observed cortisol responses in healthy individuals...
March 1, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28291646/does-seasonal-vaccination-affect-the-clinical-presentation-of-influenza-among-the-elderly-a-cross-sectional-analysis-in-the-outpatient-setting-in-france-2003-2014
#20
Anne Mosnier, Isabelle Daviaud, Saverio Caini, Hervé Berche, Jean-Michel Mansuy, Sylvie van der Werf, Jean Marie Cohen, Bruno Lina
Vaccine-induced protection against influenza is not optimal, however it has been suggested that the vaccine may reduce the severity of symptoms among those who develop illness despite being vaccinated. We tested this hypothesis within a countrywide, sentinel general practitioners-based surveillance system in France. We included 2277 individuals aged 65years or older (of whom 1293 had been vaccinated against influenza, 56.8%) who consulted a general practitioner because of an acute respiratory infection (ARI) during 2003-2014...
March 10, 2017: Vaccine
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