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https://www.readbyqxmd.com/read/29046034/-neurological-manifestations-in-atypical-kawasaki-disease
#1
Edgar Martínez-Guzmán, Luisa Berenise Gámez-González, Francisco Rivas-Larrauri, Giovanni Sorcia-Ramírez, Marco Yamazaki-Nakashimada
BACKGROUND: Kawasaki disease (KD) is a type of systemic vasculitis of unknown etiology. Atypical Kawasaki disease is defined as that where there are signs and symptoms not corresponding to the classical criteria for this nosological entity. Children with atypical Kawasaki disease may present with acute abdominal symptoms, meningeal irritation, pneumonia or renal failure. CLINICAL CASES: We describe 4 children with ages ranging from 2 to 12 years who had atypical Kawasaki disease, with neurological and gastrointestinal symptoms as part of the systemic presentation of the disease...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29042695/living-donor-liver-transplantation-for-acute-liver-failure-comparing-guidelines-on-the-prediction-of-liver-transplantation
#2
Kazuhiro Yoshida, Yuzo Umeda, Akinobu Takaki, Takeshi Nagasaka, Ryuichi Yoshida, Daisuke Nobuoka, Takashi Kuise, Kosei Takagi, Tetsuya Yasunaka, Hiroyuki Okada, Takahito Yagi, Toshiyoshi Fujiwara
Determining the indications for and timing of liver transplantation (LT) for acute liver failure (ALF) is essential. The King's College Hospital (KCH) guidelines and Japanese guidelines are used to predict the need for LT and the outcomes in ALF. These guidelines' accuracy when applied to ALF in different regional and etiological backgrounds may differ. Here we compared the accuracy of new (2010) Japanese guidelines that use a simple scoring system with the 1996 Japanese guidelines and the KCH criteria for living donor liver transplantation (LDLT)...
October 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29035725/alterations-to-juvenile-zebrafish-danio-rerio-swim-performance-after-acute-embryonic-exposure-to-sub-lethal-exposures-of-hydraulic-fracturing-flowback-and-produced-water
#3
Erik J Folkerts, Tamzin A Blewett, Yuhe He, Greg G Goss
Hydraulic fracturing flowback and produced water (FPW) is a wastewater produced during fracturing activities in an operating well which is hyper saline and chemically heterogeneous in nature, containing both anthropogenic and petrogenic chemicals. Determination of FPW associated toxicity to embryonic fish is limited, while investigation into how embryonic exposures may affect later life stages is not yet studied. Zebrafish embryos (24hrs post fertilization) were acutely exposed to 2.5% and 5% FPW fractions for either 24 or 48hrs and returned to freshwater...
October 7, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29034989/neurological-presentations-revealing-acquired-copper-deficiency-diagnosis-features-etiologies-and-evolution-in-seven-patients
#4
Aurélia Poujois, Nouzha Djebrani-Oussedik, Fabienne Ory-Magne, France Woimant
BACKGROUND: acquired copper deficiency (ACD) is a rare condition usually diagnosed from haematological changes. AIMS: characterize the diagnosis features and the evolution of patients with ACD revealed by neurological symptoms. METHODS: clinical, biological and MRI data were prospectively analysed at diagnosis and during follow-up under copper supplementation. RESULTS: seven patients were studied over a 5-year period...
October 16, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29034035/surgical-embolectomy-for-acute-pulmonary-thromboembolism
#5
REVIEW
Ikuo Fukuda, Kazuyuki Daitoku
Acute pulmonary thromboembolism is a catastrophic event, especially for hospitalized patients. The prognosis of pulmonary thromboembolism depends on the degree of pulmonary arterial occlusion. The mortality of massive pulmonary embolism is reportedly as high as 25% without cardiopulmonary arrest and 65% with cardiopulmonary arrest. In patients with unstable hemodynamics due to pulmonary thromboembolism, surgical pulmonary embolectomy is indicated for patients with a contraindication to thrombolysis, failed catheter therapy, or failed thrombolysis...
June 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29033350/phenotypical-characterization-of-human-rhinovirus-infections-in-severely-premature-children
#6
Geovanny F Perez, Bassem Kurdi, Rosemary Megalaa, Krishna Pancham, Shehlanoor Huseni, Natalia Isaza, Carlos E Rodriguez-Martinez, Dinesh Pillai, Gustavo Nino
BACKGROUND: Human Rhinovirus (HRV) has been identified as the most common cause of acute respiratory infections and hospitalizations in premature children. It is unclear if premature children are more susceptible to HRV due to their decreased pulmonary reserve or because they have enhanced lower airway reactivity to HRV. METHODS: We conducted a retrospective analysis of the clinical respiratory presentation of all PCR-confirmed HRV infections in full-term and premature children aged ≤3 years in our institution...
September 27, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29030252/sub-clonal-analysis-of-the-murine-c1498-acute-myeloid-leukaemia-cell-line-reveals-genomic-and-immunogenic-diversity
#7
Virginie Driss, Frédéric Leprêtre, Isabelle Briche, Alexia Mopin, Céline Villenet, Martin Figeac, Bruno Quesnel, Carine Brinster
BACKGROUND: In acute myeloid leukaemia (AML)-affected patients, the presence of heterogeneous sub-clones at diagnosis has been shown to be responsible for minimal residual disease and relapses. The role played by the immune system in this leukaemic sub-clonal hierarchy and maintenance remains unknown. As leukaemic sub-clone immunogenicity could not be evaluated in human AML xenograft models, we assessed the sub-clonal diversity of the murine C1498 AML cell line and the immunogenicity of its sub-clones in immune-competent syngeneic mice...
October 10, 2017: Immunology Letters
https://www.readbyqxmd.com/read/29029390/extracellular-truncated-tau-causes-early-presynaptic-dysfunction-associated-with-alzheimer-s-disease-and-other-tauopathies
#8
Fulvio Florenzano, Corsetti Veronica, Gabriele Ciasca, Maria Teresa Ciotti, Anna Pittaluga, Gunedalina Olivero, Marco Feligioni, Filomena Iannuzzi, Valentina Latina, Michele Francesco Maria Sciacca, Alessandro Sinopoli, Danilo Milardi, Giuseppe Pappalardo, De Spirito Marco, Massimiliano Papi, Anna Atlante, Antonella Bobba, Antonella Borreca, Pietro Calissano, Giuseppina Amadoro
The largest part of tau secreted from AD nerve terminals and released in cerebral spinal fluid (CSF) is C-terminally truncated, soluble and unaggregated supporting potential extracellular role(s) of NH2 -derived fragments of protein on synaptic dysfunction underlying neurodegenerative tauopathies, including Alzheimer's disease (AD). Here we show that sub-toxic doses of extracellular-applied human NH2 tau 26-44 (aka NH 2 htau) -which is the minimal active moiety of neurotoxic 20-22kDa peptide accumulating in vivo at AD synapses and secreted into parenchyma- acutely provokes presynaptic deficit in K(+) -evoked glutamate release on hippocampal synaptosomes along with alteration in local Ca(2+) dynamics...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29026307/porous-se-sio2-nanospheres-treated-paraquat-induced-acute-lung-injury-by-resisting-oxidative-stress
#9
Yong Zhu, Guoying Deng, Anqi Ji, Jiayi Yao, Xiaoxiao Meng, Jinfeng Wang, Qian Wang, Qiugen Wang, Ruilan Wang
Acute paraquat (PQ) poisoning is one of the most common forms of pesticide poisoning. Oxidative stress and inflammation are thought to be important mechanisms in PQ-induced acute lung injury (ALI). Selenium (Se) can scavenge intracellular free radicals directly or indirectly. In this study, we investigated whether porous Se@SiO2 nanospheres could alleviate oxidative stress and inflammation in PQ-induced ALI. Male Sprague Dawley rats and RLE-6TN cells were used in this study. Rats were categorized into 3 groups: control (n=6), PQ (n=18), and PQ + Se@SiO2 (n=18)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29024685/cardiac-pathologic-findings-in-three-unusual-cases-of-sudden-cardiac-death-related-to-anorexiant-drugs
#10
Ornella Leone, Valentina Agostini, Alberto Foà, Bruna Cerbelli, Cira Rosaria Tiziana di Gioia, Mariarosaria Aromatario, Costantino Ciallella, Joaquin Lucena, Giulia d'Amati
Amphetamine congeners can be prescribed as anorexiant drugs, despite their potential side effects, including cardiac toxicity. However, the morphologic features of cardiac damage related to protracted use of these compounds are unknown. We provide a detailed description of cardiac autopsy findings in three cases of sudden death associated with protracted use of high-doses of phendimetrazine and/or phenylpropanolamine or bupropion prescribed as anorexiants, in association with other compounds. The main cardiac findings were similar in all three cases: i) mild-moderate hypertrophy of the left ventricle and/or the septum; ii) myocardial non-ischemic scarring (mid-mural and/or sub-epicardial) appearing as discrete foci or with a band/like morphology; iii) mild-moderate intramural small vessel disease, in absence of significant epicardial coronary artery stenosis; iv) acute/recent inflammatory lesions consistent with toxic myocarditis...
October 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/29023930/evaluation-and-treatment-of-acute-and-subacute-hearing-loss-a-review-of-pharmacotherapy
#11
Maryam T Fazel, Patrick M Jedlowski, Robert B Cravens, Brian L Erstad
Among various forms of hearing loss, there are acute (within 72 hours) or sub-acute (weeks to months) presentations that may be reversible with early pharmacological intervention. The workup of a patient presenting with hypoacusia includes the usual history and physical examination in conjunction with an audiometric assessment in order to categorize the hearing loss as conductive, sensorineural, or mixed. Sudden sensorineural hearing loss (SSNHL) and autoimmune inner ear disease (AIED) are acute and subacute forms of sensorineural hypoacusia most likely to be reversed with prompt pharmacological intervention...
October 10, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29022532/hiv-positive-patients-in-the-intensive-care-unit-a-retrospective-audit
#12
P Mkoko, R I Raine
BACKGROUND: The indications for and outcomes of intensive care unit (ICU) admission of HIV-positive patients in resource-poor settings such as sub-Saharan Africa are unknown. OBJECTIVE: To identify indications for ICU admission and determine factors associated with high ICU and hospital mortality in HIV-positive patients. METHODS: We reviewed case records of HIV-positive patients admitted to the medical and surgical ICUs at Groote Schuur Hospital, Cape Town, South Africa, from 1 January 2012 to 31 December 2012...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29022371/external-validation-of-acute-to-chronic-models-for-estimation-of-reproductive-toxicity-to-daphnia-magna
#13
A Furuhama, T I Hayashi, H Yamamoto, N Tatarazako
We evaluated the predictivity and applicability of previously proposed models for the reproductive toxicity of chemicals to Daphnia magna [SAR QSAR Environ. Res. 27:10, 833-850] by using external data from the United States Environmental Protection Agency database ECOTOX. These models were based on quantitative structure-activity-activity relationships (QSAARs) and a quantitative activity-activity relationship (QAAR): the models can be categorized as acute-to-chronic models with (QSAAR) and without (QAAR) structural and physicochemical (e...
September 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/29021921/post-transplant-lymphoproliferative-disorder-ptld-single-institutional-experience-of-141-patients
#14
Rohit Bishnoi, Ravneet Bajwa, Aaron J Franke, William Paul Skelton, Yu Wang, Niraj M Patel, William Birdsall Slayton, Fei Zou, Nam H Dang
BACKGROUND: Post-transplant lymphoproliferative disorder is a well-recognized but rare complication of hematopoietic stem cell and solid organ transplant. Due to rarity of this disease, retrospective studies from major transplant centers has been the main source to provide treatment guidelines, which are still in evolution. The sample size of this study is among one of the largest study on PTLD till date reported throughout the world. METHODS: This study was performed at University of Florida which is one of the largest transplant center in South East United States...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/29021851/cardiac-troponin-t-as-a-predictor-of-cardiac-death-in-patients-with-left-ventricular-dysfunction
#15
Hironori Nakamura, Shinichi Niwano, Hidehira Fukaya, Masami Murakami, Jun Kishihara, Akira Satoh, Tomoharu Yoshizawa, Jun Oikawa, Naruya Ishizue, Tazuru Igarashi, Tamami Fujiishi, Junya Ako
BACKGROUND: Cardiac troponin T (cTnT) has been reported to be associated with cardiac mortality. In the present study, we evaluated the role of routine assessment of cTnT as a predictor of future cardiac death in patients with left ventricular (LV) dysfunction. METHODS: Patients who were eligible for prophylactic implantable cardioverter defibrillator (ICD) were included from cardiac catheterization database. Inclusion criteria were patients with LV ejection fraction of ≤ 35% and with New York Heart Association (NYHA) ≥class II...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29020958/does-replacing-sedentary-behaviour-with-light-or-moderate-to-vigorous-physical-activity-modulate-inflammatory-status-in-adults
#16
Catherine M Phillips, Christina B Dillon, Ivan J Perry
BACKGROUND: Sedentary behaviour, obesity and insulin resistance are associated with pro-inflammatory status. Limited data on whether physical activity modulates inflammatory status and counteracts obesity and insulin resistance associated low-grade inflammation exist. Our objective was to investigate associations between objectively measured physical activity and inflammatory status, and specifically whether substituting daily sedentary behaviour with light activity or moderate to vigorous physical activity (MVPA), is associated with beneficial alterations to the inflammatory profile among middle-aged adults and those at increased cardiometabolic risk (obese and insulin resistant subjects)...
October 11, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29020940/the-epidemiology-and-transmission-of-methicillin-resistant-staphylococcus-aureus-in-the-community-in-singapore-study-protocol-for-a-longitudinal-household-study
#17
Nivedita Shankar, Angela Li Ping Chow, Jolene Oon, Li Yang Hsu, Brenda Ang, Junxiong Pang, Paola Florez De Sessions, Balamurugan Periaswamy, Paul A Tambyah, Desmond B Teo, Clarence C Tam
BACKGROUND/AIM: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common multidrug-resistant organisms in healthcare settings worldwide, but little is known about MRSA transmission outside of acute healthcare settings especially in Asia. We describe the methods for a prospective longitudinal study of MRSA prevalence and transmission. METHODS: MRSA-colonized individuals were identified from MRSA admission screening at two tertiary hospitals and recruited together with their household contacts...
October 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29020866/cause-and-timing-of-death-and-sub-group-differential-effects-of-erythropoietin-in-the-epo-tbi-study
#18
Markus Benedict Skrifvars, Craig French, Michael Bailey, Jeffrey Presneill, Alistair Nichol, Lorraine Little, Jacques Duranteau, Olivier Huet, Samir Haddad, Yaseen Arabi, Colin McArthur, D James Cooper, Rinaldo Bellomo
The EPO-TBI study randomised 606 patients with moderate or severe traumatic brain injury (TBI) to be treated with weekly epoetin alfa (EPO) or placebo. Six-month mortality was lower in EPO treated patients in an analysis adjusting for TBI severity. Knowledge of possible differential effects by TBI injury subtype and acute neurosurgical treatment as well as timing and cause of death (COD) will facilitate the design of future interventional TBI trials. We defined COD as cerebral (brain death, cerebral death with withdrawal or death during maximal care) and non-cerebral (death following withdrawal or during maximal care due to a non-cerebral cause)...
October 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29020847/neurolipids-and-microrna-changes-in-blood-following-blast-traumatic-brain-injury-in-mice-an-exploratory-study
#19
Venkata Siva Sai Sujith Sajja, Anna Jablonska, Norman J Haughey, Jeff W M Bulte, Robert D Stevens, Joseph Long, Piotr Walczak, Miroslaw Janowski
At present, accurate and reliable biomarkers to ascertain the presence, severity, or prognosis of blast traumatic brain injury (bTBI) are lacking. There is an urgent need to establish accurate and reliable biomarkers capable of mbTBI detection. Currently, there are no studies that identify changes in miRNA and lipids at varied severities of bTBI. Various biological components such as lipids, circulating mRNA, and miRNA, could potentially be detected using advanced techniques such as next-generation sequencing and mass spectroscopy...
October 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29019421/management-of-acute-pain-in-the-postoperative-setting-the-importance-of-quality-indicators
#20
Winfried Meissner, Frank Huygen, Edmund A M Neugebauer, Jürgen Osterbrink, Dan Benhamou, Neil Betteridge, Flaminia Coluzzi, José De Andres, William Fawcett, Dominique Fletcher, Eija Kalso, Henrik Kehlet, Bart Morlion, Antonio Montes Pérez, Joseph Pergolizzi, Michael Schäfer
Despite the introduction of evidence-based recommendations for postoperative pain management (POPM), the consensus is that pain control remains suboptimal. Barriers to achieving patient-satisfactory analgesia include deficient knowledge regarding POPM among staff, lack of instructions, insufficient pain assessments and sub-optimal treatment. Effective monitoring of POPM is essential to enable policy makers and healthcare providers to improve the quality of care. Quality indicators (QIs) are quantitative measures of clinical practice that can monitor, evaluate and guide the quality of care provided to patients...
October 11, 2017: Current Medical Research and Opinion
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