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John Lyles, Richard Falcone, Samuel Kocoshis
No abstract text is available yet for this article.
September 18, 2018: Gastroenterology
Petri Karkkola, Sanna Sinikallio, Niko Flink, Kirsi Honkalampi, Matti Kuittinen
Background and aims Pain is a common condition. However, only a minority of people experiencing pain develop a chronic pain problem. Factors such as somatization, pain self-efficacy and lack of psychological well-being affect the risk of pain chronicity and pain-related disability. However, research on protective pain-related psychological factors in populations without chronic pain is scarce. We aim to examine if pain self-efficacy attenuates the associations between pain and both anxiety and somatization in a community sample...
September 21, 2018: Scandinavian Journal of Pain
Vikas Yadav Patade, Harsahay Meena, Atul Grover, Sanjay Mohan Gupta, M Nasim
The present study reports engineered cold tolerance and toxicity analysis in genetically modified tomato ( Solanum lycopersicum L. cv. Pusa Ruby) developed through constitutive over expression of Nicotiana tabacum Osmotin gene. Rate of seed germination, seedling establishment and growth remained unaffected in the transgenic tomato in response to a low temperature (15 °C) treatment, but were significantly ( P  ≤ 0.05) reduced in the wild type. At reproductive stage, the wild type plants failed to recover at the low temperature (4...
October 2018: 3 Biotech
Vikash Talib, Shazia Sultana, Ahmed Hamad, Uzair Yaqoob
Wernicke's encephalopathy (WE) is a life-threatening acute or sub-acute neurological emergency characterized by ataxia, confusion, nystagmus, and ophthalmoparesis caused by thiamine deficiency. It was first described in 1881 by Carl Wernicke with alcohol being the most common cause. We present a rare case of a 35-year-old pregnant female who presented to our emergency department with a history of vomiting and loose motions for two weeks. She later developed fever, confusion, slurred speech and blurring of vision...
July 17, 2018: Curēus
Victor Kim, Shawn D Aaron
Chronic Obstructive Pulmonary Disease (COPD) is a chronic illness that may be periodically punctuated by exacerbations, characterised by acute worsening of dyspnea, and/or cough and sputum production, and/or increased sputum purulence. COPD exacerbations are common and carry with them important clinical and economic consequences including lost work productivity, increased utilisation of health care resources, temporary or permanent reductions in lung function and exercise capacity, hospitalisation, and sometimes death...
September 20, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Elham E Amin, Ingrid M Bistervels, Karina Meijer, Lidwine W Tick, Saskia Middeldorp, Guy Mostard, Marlène van de Poel, Erik H Serné, Hans M Otten, Edith M Klappe, Manuela A Joore, Hugo Ten Cate, Marije Ten Wolde, Arina J Ten Cate-Hoek
Thus far the association between residual vein occlusion and immediate compression therapy and post thrombotic syndrome is undetermined. Therefore, we investigated whether compression therapy immediately after diagnosis of deep vein thrombosis affects the occurrence of residual vein obstruction, (RVO) and whether the presence of RVO is associated with post thrombotic syndrome and recurrent venous thromboembolism. In a pre-specified sub study within the IDEAL DVT trial, 592 adult patients from 10 academic and non-academic centers across the Netherlands, with objectively confirmed proximal deep vein thrombosis of the leg, received no compression or acute compression within 24 hours of diagnosis of deep vein thrombosis with either multi-layer bandaging or compression hosiery (pressure 35mmHg)...
September 20, 2018: Blood
L Tedesco Triccas, J H Burridge, A M Hughes, K L Meadmore, M Donovan-Hall, J C Rothwell, G Verheyden
Background Neurorehabilitation technologies used mainly in research such as robot therapy (RT) and transcranial direct current stimulation (tDCS) can promote upper limb motor recovery after stroke. Understanding the feasibility and efficacy of stroke rehabilitation technologies for upper limb impairments is crucial for effective implementation in practice. Small studies have explored views of RT by people with stroke; however experiences of people receiving tDCS in combination with RT have never been explored...
September 20, 2018: Topics in Stroke Rehabilitation
Laurent Bonello, Marc Laine, Gilles Lemesle, Etienne Puymirat, Thibaut Dabry, Franck Thuny, Franck Paganelli, Daniel Aradi, Corinne Frere, Stéphane Burtey, Dirk Sibbing, Julien Mancini
BACKGROUND:  The clinical benefit of anti-platelet agents in patients with chronic kidney disease (CKD) is uncertain. In addition, the risk-benefit ratio of potent oral P2Y12-adenosine diphosphate (ADP) receptor antagonists (PPAs), namely, prasugrel and ticagrelor, compared with clopidogrel in CKD patients suffering from acute coronary syndrome (ACS) remains unknown. OBJECTIVE:  We performed a meta-analysis of all studies comparing the clinical outcomes of PPA and clopidogrel therapy in CKD patients suffering from ACS...
September 20, 2018: Thrombosis and Haemostasis
M A Alsalem, A A Zaidan, B B Zaidan, M Hashim, O S Albahri, A S Albahri, Ali Hadi, K I Mohammed
This study aims to systematically review prior research on the evaluation and benchmarking of automated acute leukaemia classification tasks. The review depends on three reliable search engines: ScienceDirect, Web of Science and IEEE Xplore. A research taxonomy developed for the review considers a wide perspective for automated detection and classification of acute leukaemia research and reflects the usage trends in the evaluation criteria in this field. The developed taxonomy consists of three main research directions in this domain...
September 19, 2018: Journal of Medical Systems
Lesley Baillie, Nicola Thomas
AIMS AND OBJECTIVES: To investigate 1) How nursing care is organised on wards where nursing staff work different lengths of day shifts, and 2) How length of day shift affects the staffing of wards. BACKGROUND: Twelve hour shifts have become increasingly common worldwide but there are concerns about impact on care quality and safety. Eight hour shifts, and how day shift length affects how nurses organise their work, and staffing, have been little studied. DESIGN: Case study...
September 19, 2018: Journal of Clinical Nursing
Lucia Knight, Enid Schatz, Ferdinand C Mukumbang
BACKGROUND: HIV and non-communicable disease (NCD) are syndemic within sub-Saharan Africa especially among older persons. The two epidemics interact with one another within a context of poverty, inequality and inequitable access to healthcare resulting in an increase in those aged 50 and older living with HIV and experiencing an NCD co-morbidity. We explore the challenges of navigating healthcare for older persons living with HIV and NCD co-morbidity. METHODS: In-depth semi-structured interviews were conducted with a small sample of older persons living with HIV (OPLWH)...
September 18, 2018: International Journal for Equity in Health
Petra Pohl, Gunnel Carlsson, Lina Bunketorp Käll, Michael Nilsson, Christian Blomstrand
BACKGROUND: Rehabilitative stroke interventions based on principles of multimodal stimulation have the potential to profoundly affect neuroplastic processes beyond the sub-acute phase. In order to identify important core mechanisms, there is a need to explore how interventions that combine physical, social, sensory, and cognitively challenging activities are perceived and experienced by the participants. This qualitative study, based on an interpretive interactionist perspective, explored the experiences of stroke survivors who participated in a group-based multimodal rehabilitation program based on rhythm and music...
2018: PloS One
Gadi Bartur, Avi Ohry, Ofer Keren
INTRODUCTION: The presence of unintentional muscular activity, with or without overt movement, in the homologue muscle contralateral to the limb being activated voluntarily, has been documented in both healthy and hemi-paretic populations. This activity has been termed contra-lateral motor irradiation (CMI), mirror movement, associated movement, motor overflow or synkinesis. AIMS: To characterize the CMI phenomenon amongst healthy controls and patients with varying degrees of motor ability and also to assess the ability to consciously control this phenomenon...
September 2018: Harefuah
D M van Velzen, Y H Krul-Poel, M den Heijer, S Simsek
Severe hypothyroidism is known to cause elevation of creatinine and this phenomenon has been reported in clinical settings in the past. Screening for hypothyroidism is not regularly performed in the differential workup for acute kidney injury due to its rare presentation. Therefore, to most physicians hypothyroidism is not known as a cause of acute kidney injury. In this clinical case report, we describe a case of subacute kidney injury in a patient with severe hypothyroidism prior to iodine-131 ablation therapy...
September 2018: Netherlands Journal of Medicine
Bethany Radecki, Staci Reynolds, Areeba Kara
AIM: The aim of this study was to describe the patient's perspective of fall prevention in an acute care setting to aid in the design of patient centered strategies. BACKGROUND: Falls are one of the most common adverse events in hospitals and can lead to preventable patient harm, increased length of stay, and increased healthcare costs. There is a need to understand fall risk and prevention from the patients' perspectives; however, research in this area is limited...
October 2018: Applied Nursing Research: ANR
S Mohammad Ahmadi Soleimani, Mohammad Hossein Mohamadi M A H, Mohammad Reza Raoufy, Hossein Azizi, Mohammad Nasehi, Mohammad Reza Zarrindast
Increasing number of evidence support the role of ventral tegmental area (VTA) and nucleus accumbens (NAc) in mediating the opiate effects as the two critical components of brain reward pathway. It is believed that VTA to NAC dopaminergic projections mediate the reinforcing effects induced by opioid drugs. Although numerous studies have investigated mechanisms of reward processing in these brain regions, alterations of local field potentials (LFPs), as an index of total synaptic currents, has not been previously addressed...
September 13, 2018: Neuroscience Letters
I Demirkan, M Erdoğan, A Çevik Demirkan, F Bozkurt, M Altındiş, F Zemheri Navruz, Z Köse
The isolation and identification of microorganisms associated with digital dermatitis (DD) in Turkish dairy cattle was investigated using punch skin biopsy samples from typical clinical lesions; they were collected from dairy farms and abattoirs in 5 different geographical locations in Turkey. Morphological characteristics and flagellation types were examined using a transmission electron microscope, and their enzyme profiles by enzyme activation kits; their catalase reaction characteristics were evaluated by the addition of 3% H2 O2 ...
September 12, 2018: Journal of Dairy Science
Toshijiro Aoki, Hideki Ishii, Akihito Tanaka, Susumu Suzuki, Satoshi Ichimiya, Masaaki Kanashiro, Toyoaki Murohara
BACKGROUND: The combined influence of CKD and worsening renal function (WRF) on clinical outcomes in patients undergoing primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) has not been fully understood. METHODS: We analyzed 443 patients diagnosed with AMI who underwent primary PCI. Based on their estimated glomerular filtration rate (eGFR), they were classified into two groups: a high eGFR group (eGFR ≥ 45 mL/min/1.73 m2 , n = 381) and a low eGFR group (eGFR < 45 mL/min/1...
September 14, 2018: Clinical and Experimental Nephrology
Aureliano Ruggio, Daniela Pedicino, Davide Flego, Rocco Vergallo, Anna Severino, Claudia Lucci, Giampaolo Niccoli, Carlo Trani, Francesco Burzotta, Cristina Aurigemma, Antonio Maria Leone, Antonino Buffon, Alessia D'Aiello, Luigi Marzio Biasucci, Filippo Crea, Giovanna Liuzzo
BACKGROUND: A sizeable proportion of patients with Acute Coronary Syndromes (ACS) shows a unique adaptive immune system profile, associated to a worse outcome, characterized by higher CD4+ CD28null T-cells, lower regulatory T-cells (Treg) and increased CD4+ CD28null /Treg ratio. We sought to investigate the correlation between CD4+ CD28null T-cells, Treg, CD4+ CD28null /Treg ratio and plaque phenotype as assessed by Optical Coherence Tomography (OCT). METHODS: Peripheral blood mononuclear cells (PBMC) were collected from 30 Non-ST Elevation Myocardial Infarction (NSTEMI) patients, sub-grouped according to OCT analysis of culprit lesions into two cohorts: Ruptured Fibrous Cap (NSTEMI-RFC, n = 12) and Intact Fibrous Cap (NSTEMI-IFC, n = 18)...
September 7, 2018: International Journal of Cardiology
Breanna K Wodnik, Matthew C Freeman, Anna S Ellis, Emily Awino Ogutu, Amy Webb Girard, Bethany A Caruso
Exposure to fecal pathogens results in both acute and chronic sequalae in young children. Diarrhea causes nearly 20% of all under-five mortality, while even sub-clinical enteric infections may lead to growth shortfalls. Stunting affects nearly 165 million children globally and results in lifelong and intergenerational effects for the world's poorest populations. Caregiver hygiene behaviors, such as those surrounding handwashing and food preparation, play a critical role in exposure to fecal pathogens; standard metrics to assess these behaviors are warranted to provide a means of quantifying the impact these behaviors have on enteric infections and to evaluate the success or failure of interventions and programs...
September 13, 2018: International Journal of Environmental Research and Public Health
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