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https://www.readbyqxmd.com/read/29239890/omega-3-decreases-interleukin-6-levels-in-hiv-and-hhv-8-co-infected-patients-results-from-a-randomized-supplementation-trial-in-uganda
#1
Anna E Coghill, Jeanette M Schenk, Zeina Mahkoul, Jackson Orem, Warren Phipps, Corey Casper
OBJECTIVE: Kaposi sarcoma (KS) is an HIV-associated malignancy caused by human herpesvirus-8 that occurs at highest incidence in sub-Saharan Africa. KS patients often present with inflammatory symptoms associated with higher mortality. DESIGN: We conducted a double-blind, randomized, placebo-controlled study in Uganda to test whether omega-3 (ω-3) supplementation could reduce inflammation in HIV and HHV-8 co-infected adults ≥ 18 years of age. Patients with acute illness, AIDS, or advanced KS were ineligible, as were pregnant women...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239266/epidemiology-of-invasive-pulmonary-aspergillosis-in-patients-with-liver-failure-clinical-presentation-risk-factors-and-outcomes
#2
Xuan Zhang, Meifang Yang, Jianhua Hu, Hong Zhao, Lanjuan Li
Objective Invasive pulmonary aspergillosis (IPA) is a severe and often lethal infection. The possible risk factors, clinical presentation, and treatment of patients with simultaneous liver failure and IPA have received little attention in previous studies. The aim of this study was to investigate the epidemiology of IPA in patients with liver failure in an effort to reduce patient mortality. Methods The patients with liver failure (including acute liver failure , sub-acute liver failure , acute-on-chronic liver failure and chronic liver failure) were recruited from 2011 to 2016...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29238569/transient-cardiac-dysfunction-but-elevated-cardiac-and-kidney-biomarkers-24%C3%A2-h-following-an-ultra-distance-running-event-in-mexican-tarahumara
#3
Dirk L Christensen, Diana Espino, Rocío Infante-Ramírez, Mónica S Cervantes-Borunda, Rosa P Hernández-Torres, Antonio E Rivera-Cisneros, Daniel Castillo, Kate Westgate, Dijana Terzic, Soren Brage, Christian Hassager, Jens P Goetze, Jesper Kjaergaard
Background: The Mexican Tarahumara are accustomed to running ultra-distance races. No data exist on the acute physiological changes following ultra-distance running and physiological-biomarker associations in this population. Thus, we aimed to investigate the acute impact (≤ 24 h) on functional and biochemical changes of the cardiac muscle and biochemical changes associated with kidney function following a 63-km ultra-distance race with an altitude difference of 1800 m in Mexican Tarahumara athletes...
2017: Extreme Physiology & Medicine
https://www.readbyqxmd.com/read/29238363/bleeding-outcomes-after-non-emergency-percutaneous-coronary-intervention-in-the-very-elderly
#4
Vimalraj Bogana Shanmugam, Dennis T Wong, Hashrul Rashid, James D Cameron, Yuvaraj Malaiapan, Peter J Psaltis
Background: Octogenarians constitute an increasing proportion of patients presenting for non-emergency percutaneous coronary intervention (PCI). Methods: This study evaluated the in-hospital procedural characteristics and outcomes, including the bleeding events of 293 octogenarians presenting between January 2010 and December 2012 for non-emergency PCI to a single large volume tertiary care Australian center. Comparisons were made with 293 consecutive patients aged less than or equal to 60 years, whose lesions were matched with the octogenarians...
October 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29237803/anti-tumor-activity-of-entrectinib-a-pan-trk-ros1-and-alk-inhibitor-in-etv6-ntrk3-positive-acute-myeloid-leukemia
#5
Kristen M Smith, Patrick C Fagan, Elena Pomari, Giuseppe Germano, Chiara Frasson, Colin Walsh, Ian M Silverman, Paolo Bonvini, Gang Li
Activation of tropomyosin receptor kinase (TRK) family tyrosine kinases by chromosomal rearrangement has been shown to drive a wide range of solid tumors and hematologic malignancies. TRK fusions are actionable targets as evidenced by recent clinical trial results in solid tumors. Entrectinib (RXDX-101) is an investigational, orally available, CNS-active, highly potent and selective kinase inhibitor against TRKA/B/C, ROS1 and ALK kinase activities. Here, we demonstrate that TRK kinase inhibition by entrectinib selectively targets preclinical models of TRK fusion-driven hematologic malignancies...
December 13, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29235509/in-vivo-metabolic-imaging-of-traumatic-brain-injury
#6
Caroline Guglielmetti, Austin Chou, Karen Krukowski, Chloe Najac, Xi Feng, Lara-Kirstie Riparip, Susanna Rosi, Myriam M Chaumeil
Complex alterations in cerebral energetic metabolism arise after traumatic brain injury (TBI). To date, methods allowing for metabolic evaluation are highly invasive, limiting our understanding of metabolic impairments associated with TBI pathogenesis. We investigated whether 13C MRSI of hyperpolarized (HP) [1-13C] pyruvate, a non-invasive metabolic imaging method, could detect metabolic changes in controlled cortical injury (CCI) mice (n = 57). Our results show that HP [1-13C] lactate-to-pyruvate ratios were increased in the injured cortex at acute (12/24 hours) and sub-acute (7 days) time points after injury, in line with decreased pyruvate dehydrogenase (PDH) activity, suggesting impairment of the oxidative phosphorylation pathway...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29231855/differences-of-rotavirus-vaccine-effectiveness-by-country-likely-causes-and-contributing-factors
#7
REVIEW
Ulrich Desselberger
Rotaviruses are a major cause of acute gastroenteritis in infants and young children worldwide and in many other mammalian and avian host species. Since 2006, two live-attenuated rotavirus vaccines, Rotarix® and RotaTeq®, have been licensed in >100 countries and are applied as part of extended program of vaccination (EPI) schemes of childhood vaccinations. Whereas the vaccines have been highly effective in high-income countries, they were shown to be considerably less potent in low- and middle-income countries...
December 12, 2017: Pathogens
https://www.readbyqxmd.com/read/29228911/intrapartum-factors-associated-with-neonatal-hypoxic-ischemic-encephalopathy-a-case-controlled-study
#8
Vanessa E Torbenson, Mary Catherine Tolcher, Kate M Nesbitt, Christopher E Colby, Sherif A El-Nashar, Bobbie S Gostout, Amy L Weaver, Michaela E Mc Gree, Abimbola O Famuyide
BACKGROUND: Neonatal encephalopathy (NE) affects 2-4/1000 live births with outcomes ranging from negligible neurological deficits to severe neuromuscular dysfunction, cerebral palsy and death. Hypoxic ischemic encephalopathy (HIE) is the sub cohort of NE that appears to be driven by intrapartum events. Our objective was to identify antepartum and intrapartum factors associated with the development of neonatal HIE. METHODS: Hospital databases were searched using relevant diagnosis codes to identify infants with neonatal encephalopathy...
December 11, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29226816/efficacy-of-intravenous-furosemide-versus%C3%A2-a-novel-ph-neutral-furosemide-formulation-administered-subcutaneously%C3%A2-in-outpatients-with-worsening-heart%C3%A2-failure
#9
Nisha A Gilotra, Oluseyi Princewill, Bonnie Marino, Ike S Okwuosa, Jessica Chasler, Johana Almansa, Abby Cummings, Parker Rhodes, Julianne Chambers, Kimberly Cuomo, Stuart D Russell
OBJECTIVES: This study sought to determine the efficacy and safety of a novel, pH-neutral formulation of furosemide administered subcutaneously (SC) for treatment of acute decompensated heart failure (HF). BACKGROUND: Congestion requiring intravenous (IV) administration of a diuretic agent is the main reason patients with HF present for acute medical care. METHODS: Outpatients presenting with decompensated HF were randomized to receive a single SC or IV dose of furosemide...
November 27, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29223086/perceived-versus-actual-water-quality-community-studies-in-rural-oaxaca-mexico
#10
Lewis Stetson Rowles, Reinaldo Alcalde, Francisca Bogolasky, Soyoon Kum, Farith A Diaz-Arriaga, Craig Ayres, Anne M Mikelonis, Luis Javier Toledo-Flores, Manuel Gerardo Alonso-Gutiérrez, Maria Eufemia Pérez-Flores, Desmond F Lawler, Peter M Ward, Juana Yolanda Lopez-Cruz, Navid B Saleh
Compromised water quality risks public health, which becomes particularly acute in economically marginalized communities. Although the majority of the clean-water-deprived population resides in Sub-Saharan Africa and Asia, a significant portion (32 million) lives in Meso- and Latin-America. Oaxaca is one of the marginalized southern states of Mexico, which has experienced high morbidity from infectious diseases and also has suffered from a high rate of infant mortality. However, there has been a paucity of reports on the status of water quality of culturally diverse rural Oaxaca...
December 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29220784/physiological-effects-caused-by-microcystin-producing-and-non-microcystin-producing-microcystis-aeruginosa-on-medaka-fish-a%C3%A2-proteomic-and-metabolomic-study-on-liver
#11
Séverine Le Manach, Benoit Sotton, Hélène Huet, Charlotte Duval, Alain Paris, Arul Marie, Claude Yépremian, Arnaud Catherine, Lucrèce Mathéron, Joelle Vinh, Marc Edery, Benjamin Marie
Cyanobacterial blooms have become a common phenomenon in eutrophic freshwater ecosystems worldwide. Microcystis is an important bloom-forming and toxin-producing genus in continental aquatic ecosystems, which poses a potential risk to Human populations as well as on aquatic organisms. Microcystis is known to produce along with various bioactive peptides, the microcystins (MCs) that have attracted more attention notably due to their high hepatotoxicity. To better understand the effects of cyanobacterial blooms on fish, medaka fish (Oryzias latipes) were sub-chronically exposed to either non-MC-producing or MC-producing living strains and, for this latter, to its subsequent MC-extract of Microcystis aeruginosa...
December 5, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29220580/the-influence-of-adiposity-and-acute-exercise-on-circulating-hepatokines-in-normal-weight-and-overweight-obese-men
#12
Jack A Sargeant, Guruprasad P Aithal, Toshinari Takamura, Hirofumi Misu, Hiroaki Takayama, Jessica A Douglas, Mark C Turner, David J Stensel, Myra A Nimmo, David R Webb, Thomas Yates, James A King
Hepatokines are liver-secreted proteins with potential to influence glucose regulation and other metabolic parameters. This study investigated differences in adiposity status on five novel hepatokines and characterised their response to acute moderate-intensity exercise in groups of normal weight and overweight/obese men. Twenty-two men were recruited into normal weight and overweight/obese groups (BMI: 18.5 to 24.9 and 25.0 to 34.9 kg∙m<sup>-2</sup>). Each completed two experimental trials, exercise and control...
December 8, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29220516/lethal-and-sub-lethal-effects-of-four-insecticides-on-the-aphidophagous-coccinellid-adalia-bipunctata-coleoptera-coccinellidae
#13
Laura Depalo, Alberto Lanzoni, Antonio Masetti, Edison Pasqualini, Giovanni Burgio
Conventional insecticide assays, which measure the effects of insecticide exposure on short-term mortality, overlook important traits, including persistence of toxicity or sub-lethal effects. Therefore, such approaches are especially inadequate for prediction of the overall impact of insecticides on beneficial arthropods. In this study, the side effects of four modern insecticides (chlorantraniliprole, emamectin benzoate, spinosad, and spirotetramat) on Adalia bipunctata (L.) (Coleoptera: Coccinellidae) were evaluated under laboratory conditions by exposition on treated potted plants...
December 5, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29219076/-it-takes-more-than-a-fellowship-program-reflections-on-capacity-strengthening-for-health-systems-research-in-sub-saharan-africa
#14
EDITORIAL
Chimaraoke O Izugbara, Caroline W Kabiru, Djesika Amendah, Zacharie Tsala Dimbuene, Hermann Pythagore Pierre Donfouet, Esso-Hanam Atake, Marie-Gloriose Ingabire, Stephen Maluka, Joyce N Mumah, Matilu Mwau, Mollyne Ndinya, Kenneth Ngure, Estelle M Sidze, Charles Sossa, Abdramane Soura, Alex C Ezeh
Sub-Saharan Africa (SSA) experiences an acute dearth of well-trained and skilled researchers. This dearth constrains the region's capacity to identify and address the root causes of its poor social, health, development, and other outcomes. Building sustainable research capacity in SSA requires, among other things, locally led and run initiatives that draw on existing regional capacities as well as mutually beneficial global collaborations. This paper describes a regional research capacity strengthening initiative-the African Doctoral Dissertation Research Fellowship (ADDRF) program...
December 4, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29211403/the-role-of-fetal-maternal-microchimerism-as-a-natural-born-healer-in-integrity-improvement-of-maternal-damaged-kidney
#15
Abdol-Mohammad Kajbafzadeh, Shabnam Sabetkish, Nastaran Sabetkish
PURPOSE: To identify the fetal stem cell (FSC) response to maternal renal injury with emphasis on renal integrity improvement and Y chromosome detection in damaged maternal kidney. MATERIALS AND METHODS: Eight non-green fluorescent protein (GFP) transgenic Sprague- Dawley rats were mated with GFP-positive transgenic male rats. Renal damage was induced on the right kidney at gestational day 11. The same procedure was performed in eight non-pregnant rats as control group...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29208861/etiology-of-early-renal-allograft-dysfunction-and-comparison-between-dysfunction-and-function-group-a-single-center-study
#16
K M Hadiuzzaman, S F Islam, M O Faroque, R M Hossain, M Munirunnessa, S I Selim, M Morshed
Over a period of two years thirty five renal allograft recipients & donors were evaluated to find out the aetiology of early renal allograft dysfunction, in the Department of Nephrology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from March 2010 to February 2012. A comparison was made between dysfunction & functioning graft group. Mean age of recipients were (36.4±9.4) years, mean age of donors were (41.7±8.3) years, with a male and female ratio of 3:1. Fifty percent recipients showed one heliotype match, ninety percent recipients were anti CMV antibody IgG positive, few were anti CMV antibody IgM positive...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29208476/what-does-best-evidence-tell-us-about-robotic-gait-rehabilitation-in-stroke-patients-a-systematic-review-and-meta-analysis
#17
REVIEW
Maria Federica Bruni, Corrado Melegari, Maria Cristina De Cola, Alessia Bramanti, Placido Bramanti, Rocco Salvatore Calabrò
BACKGROUND: Studies about electromechanical-assisted devices proved the validity and effectiveness of these tools in gait rehabilitation, especially if used in association with conventional physiotherapy in stroke patients. OBJECTIVE: The aim of this study was to compare the effects of different robotic devices in improving post-stroke gait abnormalities. METHODS: A computerized literature research of articles was conducted in the databases MEDLINE, PEDro, COCHRANE, besides a search for the same items in the Library System of the University of Parma (Italy)...
December 2, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29205158/prognostic-impact-of-non-culprit-chronic-total-occlusions-in-infarct-related-cardiogenic-shock-results-of-the-randomized-iabp-shock-ii-trial
#18
Mohammed Saad, Georg Fuernau, Steffen Desch, Ingo Eitel, Suzanne de Waha, Janine Pöss, Taoufik Ouarrak, Steffen Schneider, Uwe Zeymer, Holger Thiele
AIMS: To investigate the impact of a chronic total occlusion (CTO) in a non-infarct-related coronary artery (non-IRA) on 1-year mortality and occurrence of cardiac arrhythmia in patients with cardiogenic shock (CS) complicating acute myocardial infarction (AMI). METHODS AND RESULTS: In a retrospective sub-analysis of the Intraaortic Balloon Pump in Cardiogenic Shock II trial (IABP-SHOCK II) and its accompanying registry, 201 (26%) of 761 patients had a CTO in a non-IR major coronary artery...
December 5, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29204942/spectrum-of-health-condition-in-methyl-isocyanate-mic-exposed-survivors-measured-after-30%C3%A2-years-of-disaster
#19
Bani Bandana Ganguly, Shouvik Mandal, Nitin N Kadam
Health effects of methyl isocyanate (MIC) exposure were mostly reported on the one-time acute exposure in Bhopal population. Epidemiological survey conducted by the Indian apex body of health research has been reported as Technical Reports, which were lacking in peer review by the expert epidemiologic scientists. The present pilot survey was aimed to measure the health effects 30 years post disaster in MIC-exposed survivors. Questionnaire-based survey has captured every health complaint in 168 individuals and grouped as systemic functions for interpreting the long-term effects of MIC...
December 5, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29203181/rotavirus-strain-diversity-in-eastern-and-southern-african-countries-before-and-after-vaccine-introduction
#20
L M Seheri, N B Magagula, I Peenze, K Rakau, A Ndadza, J M Mwenda, G Weldegebriel, A D Steele, M J Mphahlele
BACKGROUND: The African Rotavirus Surveillance Network has been detecting and documenting rotavirus genotypes in the African sub-continent since 1998 in anticipation of the rollout of rotavirus vaccination in routine Expanded Programme on Immunisation. This paper reports distribution of the rotavirus strains circulating in 15 Eastern and Southern African (ESA) countries from 2010-2015 as part of active World Health Organization (WHO) rotavirus surveillance, and investigates possibility of emergence of non-vaccine or unusual strains in six selected countries post-vaccine introduction...
December 1, 2017: Vaccine
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