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Sub Acute

G I Godahewa, Seongdo Lee, Jeongeun Kim, N C N Perera, Myoung-Jin Kim, Mun Gyeong Kwon, Bo Young Jee, Seong Don Hwang, Jehee Lee
A batch of wild common carp and largemouth bass died in Andong, Gyeongsangbuk-do province, South Korea, in 2016. Moribund fish showed typical signs of spring viremia of carp (SVC) disease, which causes acute hemorrhage in the skin and ascites. Thus far, SVC disease has been detected in several regions of the world but never in South Korea. Suspecting the infectious agent to be the SCV virus (SVCV), the moribund fish were sampled and screened. The isolated virus developed a cytopathic effect in EPC cells. Both viral isolates from the common carp (ADC-SVC2016-1) and largemouth bass (ADC-SVC2016-3) were identical in terms of their genome sequence, which were 11034 bp nucleotides in length...
July 12, 2018: Virus Research
Aravind Cherukuri, Rajil Mehta, Puneet Sood, Sundaram Hariharan
Early histological progression that associates with Delayed Graft Function (DGF) and its relationship to graft outcomes is less well understood. We systematically evaluated early acute and chronic histological changes associated with DGF through serial biopsies (protocol: 3 and 12mos; for-cause) and related them to graft outcomes. 56/294 (19.04%) of our patients had DGF. DGF was associated with a progressive increase in both Banff 't' and 'i' scores from 2 weeks to 3 and 12 months with a resultant increase in T cell mediated Rejection (TCMR) that was significantly greater than those with primary graft function (PGF)...
July 14, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
Peter Valent, Emir Hadzijusufovic, Thomas Grunt, Heidrun Karlic, Barbara Peter, Harald Herrmann, Gregor Eisenwort, Gregor Hoermann, Axel Schulenburg, Michael Willmann, Rainer Hubmann, Medhat Shehata, Edgar Selzer, Karoline V Gleixner, Thomas Rülicke, Wolfgang R Sperr, Brigitte Marian, Michael Pfeilstöcker, Hubert Pehamberger, Felix Keil, Ulrich Jäger, Christoph Zielinski
In 2008 the Ludwig Boltzmann Cluster Oncology (LBC ONC) was established on the basis of two previous Ludwig Boltzmann Institutes working in the field of hematology and cancer research. The general aim of the LBC ONC is to improve treatment of hematopoietic neoplasms by eradicating cancer-initiating and disease-propagating cells, also known as leukemic stem cells (LSC) in the context of leukemia. In a first phase, the LBC ONC characterized the phenotype and molecular aberration profiles of LSC in various malignancies...
July 13, 2018: Wiener Klinische Wochenschrift
Soukaina Bahsoun, Karen Coopman, Nicholas R Forsyth, Elizabeth Claire Akam
Most cells in the human body, including human mesenchymal stem cells (hMSCs), have evolved to survive and function in a low, physiological, oxygen (O<sub>2</sub>) environment. Investigators have become increasingly aware of the effects of O<sub>2</sub> levels on hMSC biology and culture and are mimicking the natural niche of these cells in vitro to improve cell culture yields. This presents many challenges in relation to hMSC identity and function and in the maintenance of a controlled O<sub>2</sub> environment for cell culture...
July 13, 2018: Stem Cells and Development
Ismail M Fareez, Siong Meng Lim, Kalavathy Ramasamy
Lactic acid bacteria (LAB) with probiotic properties are useful options for prophylactic and therapeutic applications against gastrointestinal diseases. The safety of probiotics should, however, be verified before incorporation into food or drinks. The present study had encapsulated Lactobacillus plantarum LAB12 within microcapsules that could withstand extremely high temperature (up to 100 °C) during pelletisation. The microencapsulated LAB12 were then tested for their acute (single dosing) and sub-chronic (a 90-day feeding) toxicity...
July 12, 2018: Probiotics and Antimicrobial Proteins
Juan Pablo Collao-Parra, César Romero-Urra, Carolina Delgado-Derio
Autoimmune encephalitis are one of the emergent causes of subacute changes in the level of consciousness, behavior, cognitive impairment and seizures, mainly in young people. They are a consequence of inflammation or dysfunction of parts of the brain caused by antibodies against specific brain antigens, usually located in the limbic system, resulting in clinical presentation as a limbic encephalitis. The objectives of this article are to show the clinical presentation, complementary studies and treatment of this entity, considering that the patient's prognostic depends on a high level of clinical suspicion, and on an early initiation of immunosuppressive therapy...
March 2018: Revista Médica de Chile
Yong Hwan Kim, Jae Jun Kim, Seong Cheol Jeong, In Sub Kim
No abstract text is available yet for this article.
May 2018: Journal of Thoracic Disease
Alireza Kazemi, Mohammadreza Sadri, Mohammad Houshmand, Narjes Yazdi, Mahin Nikougoftar Zarif, Ali Anjam-Najmedini, Rezvan Tavakoli, Mohammad Ojaghi, Mansoureh Ajami, Monireh Ajami, Amir Atashi
Although recent studies have reported different aspects of autophagy, from pro-survival to pro-death roles of this process in malignant cells, the underlying mechanisms by which autophagy inhibitors contribute toward the induction of programmed cell death in cancerous cells are still unclear. In the present study, we have attempted to explore some of the molecular features of pharmacological inhibition of autophagy in TF-1 cells (an acute erythroid leukemia model). Our findings indicated that ara-C induces autophagy (with alteration of LC3B, p62, and Beclin-1) in the cells; however, targeting autophagy by 3-methyladenine and chloroquine significantly increased caspase-dependent apoptosis and the sub-G1 compartment in ara-C-treated cells...
July 9, 2018: Anti-cancer Drugs
Benoit Christian Mouzon, Corbin Bachmeier, Joseph Ojo, Christopher Acker, Scott Ferguson, Gogce Crynen, Peter Davies, Michael Mullan, William Stewart, Fiona C Crawford
Tau pathology associated with chronic traumatic encephalopathy has been documented in the brains of individuals with a history of repetitive mild traumatic brain injury (r-mTBI). At this stage, the pathobiological role of tau in r-mTBI has not been extensively explored in appropriate preclinical models. Herein, we describe the acute and chronic behavioral and histopathological effects of single and repetitive mild TBI (five injuries given at 48 h intervals) in young adult (3 months old) hTau mice that express all six isoforms of human tau on a null murine background...
July 11, 2018: Journal of Neurotrauma
Yohanna Eriksson, Martina Boström, Åsa Sandelius, Kaj Blennow, Henrik Zetterberg, Georg Kuhn, Marie Kalm
Brain tumors are the most common form of solid tumors in children. Due to the increasing number of survivors, it is of importance to prevent long-term treatment-induced side effects. Montelukast, a leukotriene receptor antagonist, may have the desired neuroprotective properties. The aim of the study was to determine whether montelukast could reduce adverse effects of cranial irradiation (CIR) to the young brain. Daily injections of montelukast or vehicle was given to young mice for 4 or 14 days in combination with CIR or under normal conditions...
July 10, 2018: Cell Death & Disease
Koichi Takahashi, Feng Wang, Kiyomi Morita, Yuanqing Yan, Peter Hu, Pei Zhao, Abdallah Abou Zhar, Chang Jiun Wu, Curtis Gumbs, Latasha Little, Samantha Tippen, Rebecca Thornton, Marcus Coyle, Marisela Mendoza, Erika Thompson, Jianhua Zhang, Courtney D DiNardo, Nitin Jain, Farhad Ravandi, Jorge E Cortes, Guillermo Garcia-Manero, Steven Kornblau, Michael Andreeff, Elias Jabbour, Carlos Bueso-Ramos, Akifumi Takaori-Kondo, Marina Konopleva, Keyur Patel, Hagop Kantarjian, P Andrew Futreal
Mixed phenotype acute leukemia (MPAL) is a rare subtype of acute leukemia characterized by leukemic blasts presenting myeloid and lymphoid markers. Here we report data from integrated genomic analysis on 31 MPAL samples and compare molecular profiling with that from acute myeloid leukemia (AML), B cell acute lymphoblastic leukemia (B-ALL), and T cell acute lymphoblastic leukemia (T-ALL). Consistent with the mixed immunophenotype, both AML-type and ALL-type mutations are detected in MPAL. Myeloid-B and myeloid-T MPAL show distinct mutation and methylation signatures that are associated with differences in lineage-commitment gene expressions...
July 10, 2018: Nature Communications
Jaechun Hwang, Mi Ji Lee, Jong-Won Chung, Oh Young Bang, Gyeong-Moon Kim, Chin-Sang Chung, Kwang Ho Lee
Background and purpose The status of collateral vessels has important clinical implications in acute ischemic stroke. To evaluate which components of ischemic symptoms were predictive of pretreatment collateral status, we tested the hypothesis that sub-item scores from the National Institutes of Health Stroke Scale (NIHSS) are associated with leptomeningeal collateral status in acute ischemic stroke with middle cerebral artery (MCA) occlusion. Methods This study included consecutive patients with acute M1 occlusion who underwent revascularization treatment for acute MCA infarction...
January 1, 2018: Interventional Neuroradiology
Daniela Pedicino, Ada Francesca Giglio, Aureliano Ruggio, Gianluca Massaro, Alessia D'Aiello, Francesco Trotta, Claudia Lucci, Francesca Graziani, Luigi Marzio Biasucci, Filippo Crea, Giovanna Liuzzo
Over the past few decades, lot of evidences have shown atherosclerosis as a chronic progressive disease with an exquisite inflammatory feature. More recently, the role of innate immune response in the onset and progression of coronary artery disease (CAD) and an adaptive immunity imbalance, mostly involving T cell sub-sets, have been documented. Therefore, like in many other inflammatory and autoimmune disorders, an altered innate-adaptive immunity crosstalk could represent the key of the inflammatory burden leading to atherosclerotic plaque formation and progression and to the breakdown of plaque stability...
July 10, 2018: Thrombosis and Haemostasis
Murali Kesavan, J Harvey Turner, Danielle Meyrick, Sharon Yeo, Giuseppe Cardaci, Nat P Lenzo
Prostate-specific membrane antigen (PSMA)-based radiopeptide/radioligand therapy represents a rapidly expanding field in the management of metastatic castrate-resistant prostate cancer (mCRPC). However, there remains concern for the development of significant toxicities in heavily pretreated patients. In this study, the authors present their local experience, with respect to efficacy and toxicity, of 22 consecutive patients treated with lutetium-177-DOTAGA-(I-y)fk(Sub-KuE) or 177 Lu-PSMA I&T radioimmunotherapy for progressive mCRPC, followed up over 1 year...
July 10, 2018: Cancer Biotherapy & Radiopharmaceuticals
Ianthe Boden, Kate Sullivan, Claire Hackett, Brooke Winzer, Rebecca Lane, Melissa McKinnon, Iain Robertson
Background: Postoperative complications and delayed physical recovery are significant problems following emergency abdominal surgery. Physiotherapy aims to aid recovery and prevent complications in the acute phase after surgery and is commonplace in most first-world hospitals. Despite ubiquitous service provision, no well-designed, adequately powered, parallel-group, randomised controlled trial has investigated the effect of physiotherapy on the incidence of respiratory complications, paralytic ileus, rate of physical recovery, ongoing need for formal sub-acute rehabilitation, hospital length of stay, health-related quality of life, and mortality following emergency abdominal surgery...
2018: World Journal of Emergency Surgery: WJES
Jayantee Kalita, Neetu Soni, Deepanshu Dubey, Sunil Kumar, Usha Kant Misra
OBJECTIVE: To evaluate optic nerve involvement in sub acute combined degeneration (SACD) using diffusion tensor imaging (DTI) and visual evoked potential (VEP) studies, and their changes following cobalamine treatment. METHODS: Six patients with SACD and six healthy matched controls were included. Visual acuity, field and color of vision were tested. Pattern shift VEP was done, and P100 latency and amplitude were measured. Optic nerve MRI, and DTI of optic nerve to muscle ratio were measured, and fractional anisotropy ratio (FAR), axial diffusivity ratio (ADR), radial diffusion ratio (RDA) and mean diffusivity ratio (MDR) were calculated...
July 10, 2018: British Journal of Radiology
John J Friedewald, Sunil M Kurian, Raymond L Heilman, Thomas C Whisenant, Emilio D Poggio, Christopher Marsh, Prabhakar Baliga, Jonah Odim, Merideth M Brown, David N Ikle, Brian D Armstrong, Jane I Charette, Susan S Brietigam, Nedjema Sustento-Reodica, Lihui Zhao, Manoj Kandpal, Daniel R Salomon, Michael M Abecassis
Non-invasive biomarkers are needed to monitor stable patients following kidney transplantation (KT), as sub-clinical acute rejection (subAR), currently detectable only with surveillance biopsies can lead to chronic rejection and graft loss. We conducted a multi-center study to develop a blood-based molecular biomarker for subAR using peripheral blood paired with surveillance biopsies and strict clinical phenotyping algorithms for discovery and validation. At a predefined threshold, 72-75% of KT recipients achieved a negative biomarker test correlating with the absence of subAR (NPV: 78-88%), while a positive test was obtained in 25-28% correlating with the presence of subAR (PPV: 47-61%)...
July 9, 2018: American Journal of Transplantation
Muhammed Majeed, Sarang Bani, Beena Bhat, Anjali Pandey, Lakshmi Mundkur, Prakriti Neupane
The present study was taken up to evaluate the single dose acute toxicity, 28 days and 90 days repeated dose toxicity and reproductive/developmental toxicity of standardized 40% Garcinol in experimental rodents. The studies were conducted in compliance with OECD principles of good laboratory practice, guidelines for testing of chemicals no.420, 407, 408 and 421 respectively. Single dose acute oral toxicity was conducted on female Wistar rats as sighting study step-I (300 mg/kg) & sighting study step-II (2000 mg/kg) and main study (2000 mg/kg)...
2018: Toxicology Reports
Rabiat Unekwu Hamzah, Alli Abdullahi Jigam, Hussaini Anthony Makun, Evans Chidi Egwim, Hadiza Lami Muhammad, Musa Bola Busari, Gabriel Femi Ibikunle, Sulaiman Kolapo Abubakar-Akanbi
Background: This study was designed to determine the hepatoprotective effect of partially purified fractions from Pterocarpus mildbraedii extract on carbon tetrachloride (CCl4 ) intoxicated rats. Methods: The methanol extract of P. mildbraedii was subjected to solvent partitioning using n-hexane, chloroform, ethylacetate and water. Separation of fractions with proven antioxidant activity was achieved by chromatographic techniques. Acute toxicity and hepatoprotective studies of the methanol sub-fraction 6 (Me 6), methanol sub-fraction 7 (Me 7) and methanol sub-fraction 8 (Me 8) from P...
June 2018: Integrative Medicine Research
Hui Xu, Xiaocui Wang, Zhen Chen, Guanghui Bai, Bo Yin, Shan Wang, Chuanzhu Sun, Shuoqiu Gan, Zhuonan Wang, Jieli Cao, Xuan Niu, Meihua Shao, Chenghui Gu, Liuxun Hu, Limei Ye, Dandong Li, Zhihan Yan, Ming Zhang, Lijun Bai
Mild traumatic brain injury (mild TBI) is associated with dysfunctional brain network and accumulating evidence is pointing to the caudate as a vulnerable hub region. However, little is known about the longitudinal changes in the caudate-based resting-state functional connectivity following mild TBI. In the current study, 50 patients with mild TBI received resting-state functional magnetic resonance imaging as well as neuropsychological assessments within 7 days post-injury (acute phase) and 1 month later (subacute phase)...
2018: Frontiers in Neurology
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