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Hearing Preservation

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https://www.readbyqxmd.com/read/30242206/in-vivo-electrocochleography-in-hybrid-cochlear-implant-users-implicates-tmprss3-in-spiral-ganglion-function
#1
A Eliot Shearer, Viral D Tejani, Carolyn J Brown, Paul J Abbas, Marlan R Hansen, Bruce J Gantz, Richard J H Smith
Cochlear implantation, a surgical method to bypass cochlear hair cells and directly stimulate the spiral ganglion, is the standard treatment for severe-to-profound hearing loss. Changes in cochlear implant electrode array design and surgical approach now allow for preservation of acoustic hearing in the implanted ear. Electrocochleography (ECochG) was performed in eight hearing preservation subjects to assess hair cell and neural function and elucidate underlying genetic hearing loss. Three subjects had pathogenic variants in TMPRSS3 and five had pathogenic variants in genes known to affect the cochlear sensory partition...
September 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30229456/impact-of-cochlear-implantation-on-the-management-strategy-of-patients-with-neurofibromatosis-type-2
#2
Haoyue Tan, Huan Jia, Yun Li, Zhihua Zhang, Weidong Zhu, Yun Cai, Zhaoyan Wang, Hao Wu
PURPOSE: To investigate the outcomes of cochlear implantation in patients with neurofibromatosis type 2 (NF2), and to discuss the current management strategy for NF2 patients. METHODS: The medical records of NF2 patients who received cochlear implants (CI) at our center between 2012 and 2016 were retrospectively reviewed. Pre-operative hearing status, tumor status, treatment of tumors, and auditory outcomes post-implantation were evaluated. RESULTS: Twelve patients were included in the study...
September 18, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/30229403/surgical-outcome-in-smaller-symptomatic-vestibular-schwannomas-is-there-a-role-for-surgery
#3
Amrit K Chiluwal, Alyssa Rothman, Maja Svrakic, Amir R Dehdashti
BACKGROUND: Currently, there is no consensus in the initial management of small vestibular schwannomas (VSs). They are routinely watched and/or referred for radiosurgical treatment, although surgical removal is also an option. We hereby evaluate clinical outcomes of patients who have undergone surgical removal of smaller symptomatic VSs. METHODS: Patients with vestibular schwannomas (grade T1-T3b according to Hannover classification) were reviewed. Patients with symptomatic tumors who underwent surgery were evaluated...
September 18, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/30210991/the-changing-paradigm-for-the-surgical-treatment-of-large-vestibular-schwannomas
#4
Roy Thomas Daniel, Constantin Tuleasca, Alda Rocca, Mercy George, Etienne Pralong, Luis Schiappacasse, Michele Zeverino, Raphael Maire, Mahmoud Messerer, Marc Levivier
Objective  Planned subtotal resection followed by Gamma Knife surgery (GKS) in patients with large vestibular schwannoma (VS) has emerged during the past decade, with the aim of a better functional outcome for facial and cochlear function. Methods  We prospectively collected patient data, surgical, and dosimetric parameters of a consecutive series of patients treated by this method at Lausanne University Hospital during the past 8 years. Results  A consecutive series of 47 patients were treated between July 2010 and January 2018...
October 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/30199502/a-polymer-based-extended-release-system-for-stable-long-term-intracochlear-drug-delivery
#5
Erik Pierstorff, Shanshan Chen, Maria Paola Chaparro, John M Cortez, Yen-Jung Chen, Su Young Ryu, Sherry M Tsai, Marc M Baum, Wan Wan Yang, Federico Kalinec, Thomas Smith, Stacey Ludwig, William H Slattery
OBJECTIVE: Investigate a new polymer-based drug coating suitability for safe intracochlear delivery and ability to maintain long-term physiologically active levels of the corticosteroid fluticasone propionate. STUDY DESIGN: In vitro dissolution study to evaluate release profiles of polymer-coated drug particles and in vivo studies using a guinea pig model to measure perilymph drug concentrations at specific time points after implantation with polymer-coated drug particles and evaluate their effect on hearing function...
October 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/30199496/cochlear-implantation-with-a-novel-long-straight-electrode-the-insertion-results-evaluated-by-imaging-and-histology-in-human-temporal-bones
#6
Sini Sipari, Matti Iso-Mustajärvi, Hanna Matikka, Jyrki Tervaniemi, Arto Koistinen, Antti Aarnisalo, Saku T Sinkkonen, Heikki Löppönen, Aarno Dietz
HYPOTHESIS: To evaluate the insertion results of a novel straight array (EVO) by detailed imaging and subsequent histology in human temporal bones (TB). BACKGROUND: The main focuses of modern cochlear implant surgery are to prevent damage to the intracochlear structures and to preserve residual hearing. This is often achievable with new atraumatic electrode arrays in combination with meticulous surgical techniques. METHODS: Twenty fresh-frozen TBs were implanted with the EVO...
October 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/30197430/multi-option-therapy-vs-observation-for-small-acoustic-neuroma-hearing-focused-management
#7
E Zanoletti, D Cazzador, C Faccioli, S Gallo, L Denaro, D D'Avella, A Martini, A Mazzoni
The current treatment options for acoustic neuromas (AN) - observation, microsurgery and radiotherapy - should assure no additional morbidity on cranial nerves VII and VIII. Outcomes in terms of disease control and facial function are similar, while the main difference lies in hearing. From 2012 to 2016, 91 of 169 patients (54%) met inclusion criteria for the present study, being diagnosed with unilateral, sporadic, intrameatal or extrameatal AN up to 1 cm in the cerebello-pontine angle; the remaining 78 patients (46%) had larger AN and were all addressed to surgery...
August 2018: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/30191767/self-adjusted-amplification-parameters-produce-large-between-subject-variability-and-preserve-speech-intelligibility
#8
Peggy B Nelson, Trevor T Perry, Melanie Gregan, Dianne VanTasell
The current study used the self-fitting algorithm to allow listeners to self-adjust hearing-aid gain or compression parameters to select gain for speech understanding in a variety of quiet and noise conditions. Thirty listeners with mild to moderate sensorineural hearing loss adjusted gain parameters in quiet and in several types of noise. Outcomes from self-adjusted gain and audiologist-fit gain indicated consistent within-subject performance but a great deal of between-subject variability. Gain selection did not strongly affect intelligibility within the range of signal-to-noise ratios tested...
January 2018: Trends in Hearing
https://www.readbyqxmd.com/read/30190294/nimodipine-for-the-treatment-of-otolaryngic-indications
#9
Jonathan H Sin, Hira Shafeeq, Zachary D Levy
PURPOSE: The uses of nimodipine for otolaryngic indications are reviewed, and recommendations for its use in clinical practice are provided. SUMMARY: Nimodipine is currently indicated for the improvement of neurologic outcomes in adult patients with aneurysmal subarachnoid hemorrhage (aSAH). However, other oral and i.v. calcium channel blockers have not exhibited the same beneficial effects in patients with aSAH, leading clinicians to believe that nimodipine possesses unique neuroprotective effects in addition to its calcium channel-blocking and vasodilatory properties...
September 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/30186120/the-endocannabinoid-cannabinoid-receptor-2-system-protects-against-cisplatin-induced-hearing-loss
#10
Sumana Ghosh, Sandeep Sheth, Kelly Sheehan, Debashree Mukherjea, Asmita Dhukhwa, Vikrant Borse, Leonard P Rybak, Vickram Ramkumar
Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these cells against cisplatin-induced apoptosis. In the current study, we determined the distribution of CB2R in the mouse and rat cochleae and examined whether these receptors provide protection against cisplatin-induced hearing loss. In a knock-in mouse model expressing the CB2R tagged with green fluorescent protein, we show distribution of CB2R in the organ of Corti, stria vascularis, spiral ligament and spiral ganglion cells...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/30182129/local-experience-with-radiosurgery-for-vestibular-schwannomas-and-recommendations-for-management
#11
Ru Xin Wong, Hui Ying Terese Low, Daniel Yat Harn Tan
INTRODUCTION: There are many treatment options for vestibular schwannomas (VS), including radiosurgery. Previous studies have shown good outcomes for smaller tumours. We report the results of a seven-year cohort of patients with VS who were treated at our centre using a linear accelerator-based stereotactic radiosurgery system. METHODS: We retrospectively reviewed the case notes and magnetic resonance (MR) images of patients with VS treated with radiosurgery. Treatment was administered as either a single 13 Gy session or 25 Gy in five sessions...
September 5, 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/30180915/effects-of-cyberknife-therapy-for-vestibular-schwannoma-on-hearing-a-retrospective-study
#12
O Çakır, G Berkiten, B Tutar, A B Yılmazer, T L Kumral, Z Saltürk, Y Uyar
OBJECTIVES: To evaluate the effects of CyberKnife stereotactic radiotherapy for the treatment of vestibular schwannoma on hearing, as evaluated by audiological tests. METHODS: Patients with vestibular schwannoma were evaluated before and after CyberKnife radiosurgery. Evaluation included pure tone thresholds, speech discrimination scores, auditory brainstem responses and radiological signs. RESULTS: The study comprised 26 patients diagnosed with vestibular schwannoma and subsequently treated with CyberKnife radiosurgery...
September 5, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/30180712/sensorineural-hearing-loss-impairs-sensitivity-but-spares-temporal-integration-for-detection-of-frequency-modulation
#13
Nicolas Wallaert, Léo Varnet, Brian C J Moore, Christian Lorenzi
The effect of the number of modulation cycles ( N ) on frequency-modulation (FM) detection thresholds (FMDTs) was measured with and without interfering amplitude modulation (AM) for hearing-impaired (HI) listeners, using a 500-Hz sinusoidal carrier and FM rates of 2 and 20 Hz. The data were compared with FMDTs for normal-hearing (NH) listeners and AM detection thresholds (AMDTs) for NH and HI listeners [Wallaert, Moore, and Lorenzi (2016). J. Acoust. Soc. 139 , 3088-3096; Wallaert, Moore, Ewert, and Lorenzi (2017)...
August 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/30176926/effectiveness-of-skull-x-ray-to-determine-cochlear-implant-insertion-depth
#14
Vinay Fernandes, Yiqiao Wang, Robert Yeung, Sean Symons, Vincent Lin
BACKGROUND: Cochlear implant (CI) insertion depth can affect residual hearing preservation, tonotopic range coverage, and Mapping. Therefore, determining insertion depth has the potential to maximize CI performance. A post-op skull X-RAY is commonly used to assess insertion depth, however its effectiveness has not been well established. Our primary objective was to assess the accuracy of post-op skull X-RAYs to determine insertion depth, compared to CT as the gold standard. Secondary objectives were to compare experience level of raters and different skull X-RAY views...
September 3, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/30169471/hearing-restoration-during-vestibular-schwannoma-surgery-with-transcanal-approach-anatomical-and-functional-preliminary-report
#15
Daniele Marchioni, Sheila Veronese, Marco Carner, Andrea Sacchetto, Luca Sacchetto, Barbara Masotto, Luca Bianconi
OBJECTIVE: Hearing restoration has always been a dream in vestibular schwannoma (VS) surgery. The aim of this study is to describe an endoscopic assisted transcanal retrocochlear approach to the internal auditory canal (IAC) with total removal of the VS; simultaneously we assessed the anatomical and functional aspects of hearing restoration with cochlear implant (CI). STUDY DESIGN: A retrospective case series. SETTING: Tertiary referral center...
August 30, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/30139697/simultaneous-supervision-by-microscope-of-endoscope-assisted-microsurgery-via-presigmoid-retrolabyrinthine-approach-a-pilot-study
#16
H-Y Tan, J Yang, Z-Y Wang, W-D Zhu, Y-C Chai, H Jia, H Wu
OBJECTIVE: To examine the impact of integrated hybrid operating rooms for endoscope-assisted microsurgery using the presigmoid retrolabyrinthine (RL) approach, and to determine the value of simultaneous supervision of skull base endoscopic procedures by microscope. MATERIAL AND METHODS: We retrospectively reviewed endoscope-assisted surgery using the RL approach at our institution between September 2013 and January 2017. The simultaneous supervision of endoscopic procedures by microscope was realized using the integrated hybrid system...
August 20, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/30138146/facial-nerve-decompression
#17
Nicholas S Andresen, Daniel Q Sun, Marlan R Hansen
PURPOSE OF REVIEW: Facial nerve paralysis is a debilitating condition. Bell's palsy and temporal bone trauma are common causes of acute facial palsy, with recurrent idiopathic paralysis and Melkersson-Rosenthal syndrome accounting for a smaller subset of cases. Properly selected patients may benefit from facial nerve decompression. This article will review the relevant literature on facial nerve decompression. RECENT FINDINGS: The middle cranial fossa approach provides access to the primary site of lesion in Bell's palsy while preserving hearing...
October 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/30132125/hearing-preservation-in-children-with-electric-acoustic-stimulation-after-cochlear-implantation-outcome-after-electrode-insertion-with-minimal-insertion-trauma
#18
T Rader, A Bohnert, C Matthias, D Koutsimpelas, M-A Kainz, S Strieth
BACKGROUND: Cochlear implantation in patients with functional residual low-frequency hearing is performed according to an established hearing-preserving surgical technique in order to cause minimal trauma of inner ear structures. Due to the increasing number of cochlear implants in children, the preservation of residual hearing is becoming increasingly important in this patient collective. OBJECTIVES: Short- and mid-term hearing preservation outcome in pediatric patients is investigated...
August 21, 2018: HNO
https://www.readbyqxmd.com/read/30131074/combined-effect-of-non-bacteriolytic-antibiotic-and-inhibition-of-matrix-metalloproteinases-prevents-brain-injury-and-preserves-learning-memory-and-hearing-function-in-experimental-paediatric-pneumococcal-meningitis
#19
Lukas Muri, Denis Grandgirard, Michelle Buri, Michael Perny, Stephen L Leib
BACKGROUND: Pneumococcal meningitis is associated with high mortality and morbidity rates. Up to 50% of survivors show neurologic sequelae including hearing loss, cognitive impairments and learning disabilities, being particularly detrimental in affected infants and children where adjuvant therapy with dexamethasone has no proven beneficial effect. We evaluated the effect of concomitantly targeting specific pathophysiological mechanisms responsible for brain damage-i.e. matrix-metalloproteinase (MMP) activity and the exacerbated cerebral inflammation provoked through antibiotic-induced bacterial lysis...
August 21, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/30130845/morbidity-rate-of-the-retrosigmoid-versus-translabyrinthine-approach-for-vestibular-schwannoma-resection
#20
Sami Obaid, Ioannis Nikolaidis, Musaed Alzahrani, Robert Moumdjian, Issam Saliba
Background and Objectives: Controversy related to the choice of surgical approach for vestibular schwannoma (VS) resection remains. Whether the retrosigmoid (RS) or translabyrinthine (TL) approach should be performed is a matter of debate. In the context of a lack of clear evidence favoring one approach, we conducted a retrospective study to compare the morbidity rate of both surgical approaches. Subjects and Methods: 168 patients underwent surgical treatment (2007-2013) for VS at our tertiary care center...
August 22, 2018: Journal of Audiology & Otology
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