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Hearing Preservation

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https://www.readbyqxmd.com/read/30015752/the-novel-peptide-vaccine-gv1001-protects-hearing-in-a-kanamycin-induced-ototoxicity-mouse-model
#1
So Young Kim, Gaon Jung, Ye Ji Shim, Ja-Won Koo
HYPOTHESIS: We tested whether GV1001 has any ototoxic side effects at different doses and whether it protects hearing in an aminoglycoside-induced ototoxicity mouse model. BACKGROUND: GV1001, a novel peptide vaccine currently being examined in a Phase 3 clinical trial to treat pancreatic cancer, also has anti-inflammatory and antioxidant effects. METHODS: In the first experiment, C57/BL6 mice were injected with GV1001 preparations at concentrations of 0...
July 13, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/30010498/evaluating-inter-aural-hearing-preservation-in-bilateral-paediatric-cochlear-implantation
#2
Huw A S Jones, Harry R F Powell, Andy Hall, Jeremy Lavy, Azhar Shaida, Shakeel Saeed, Sherif Khalil
OBJECTIVE: To examine inter-aural hearing preservation results in children undergoing simultaneous bilateral cochlear implantation (CI). METHODS: Retrospective case review in tertiary referral centre. All children undergoing simultaneous bilateral CI between January 2013 and June 2014 (18 months). Patients eligible for inclusion in the study had pre-operative hearing thresholds of <90 dB at 250 Hz and ≥100 dB at 500 Hz. Patients with anatomical cochlear anomalies or missing data were excluded...
July 16, 2018: Cochlear Implants International
https://www.readbyqxmd.com/read/30009175/potential-of-gene-and-cell-therapy-for-inner-ear-hair-cells
#3
REVIEW
Min Yong Lee, Yong-Ho Park
Sensorineural hearing loss is caused by the loss of sensory hair cells (HCs) or a damaged afferent nerve pathway to the auditory cortex. The most common option for the treatment of sensorineural hearing loss is hearing rehabilitation using hearing devices. Various kinds of hearing devices are available but, despite recent advancements, their perceived sound quality does not mimic that of the "naïve" cochlea. Damage to crucial cochlear structures is mostly irreversible and results in permanent hearing loss...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30009114/postoperative-cochlear-obliteration-after-retrosigmoid-approach-in-patients-with-vestibular-schwannoma
#4
Alireza Hedjrat, Konrad Schwager, Erich Hofmann, Robert Behr
Objective  Vestibular schwannomas (VSNs) account for the vast majority of lesions located in the cerebellopontine angle (CPA). The goals of VSN surgery are possible total tumor removal, intact facial nerve function, and preservation of cochlear nerve function. In cases of pre- or postoperative deafness, restoration of hearing with auditory brainstem implant (ABI) or cochlear implant (CI) is a promising treatment option with normally better results in CI than in ABI. The aim of this retrospective study is to evaluate cochlear ossification or obliteration secondary to a retrosigmoid approach, which is important for later CI, especially in single-sided deafness...
August 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/30009113/impact-of-cochlear-dose-on-hearing-preservation-following-stereotactic-radiosurgery-and-fractionated-stereotactic-radiotherapy-for-the-treatment-of-vestibular-schwannoma
#5
Lawrance K Chung, Nolan Ung, John P Sheppard, Thien Nguyen, Carlito Lagman, Winward Choy, Stephen Tenn, Nader Pouratian, Percy Lee, Tania Kaprealian, Michael Selch, Antonio De Salles, Quinton Gopen, Isaac Yang
Objective  The objective of this study was to examine the effect of cochlear dose on hearing preservation in stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (fSRT) for vestibular schwannoma (VS). Design  This is a retrospective case-control study. Setting  This study was completed at the Ronald Reagan UCLA Medical Center, a university-affiliated tertiary care center. Participants  Patients who underwent SRS (marginal dose of 12 Gy) or fSRT (marginal dose of 50.4 Gy) procedures for VS were included in the study...
August 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/30006113/hearing-preservation-at-low-frequencies-by-insulin-like-growth-factor-1-in-a-guinea-pig-model-of-cochlear-implantation
#6
Kohei Yamahara, Koji Nishimura, Hideaki Ogita, Juichi Ito, Takayuki Nakagawa, Ichiro Furuta, Tomoko Kita, Koichi Omori, Norio Yamamoto
The hybrid or electric-acoustic stimulation cochlear implant is indicated in patients with a residual hearing at low frequencies. It provides electric and acoustic stimulation for compensating for high- and low-frequency sounds, respectively. However, the implantation procedure damages the cochlea, resulting in loss of the residual-hearing and diminished effects of the acoustic-hearing in several patients. To prevent hearing loss after implantation, corticosteroids have been used clinically although their effects are limited...
July 6, 2018: Hearing Research
https://www.readbyqxmd.com/read/29997477/cochlear-gene-therapy-for-sensorineural-hearing-loss-current-status-and-major-remaining-hurdles-for-translational-success
#7
REVIEW
Wenjuan Zhang, Sun Myoung Kim, Wenwen Wang, Cuiyuan Cai, Yong Feng, Weijia Kong, Xi Lin
Sensorineural hearing loss (SNHL) affects millions of people. Genetic mutations play a large and direct role in both congenital and late-onset cases of SNHL (e.g., age-dependent hearing loss, ADHL). Although hearing aids can help moderate to severe hearing loss the only effective treatment for deaf patients is the cochlear implant (CI). Gene- and cell-based therapies potentially may preserve or restore hearing with more natural sound perception, since their theoretical frequency resolution power is much higher than that of cochlear implants...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29995008/minimally-invasive-ponto-surgery-versus-the-linear-incision-technique-with-soft-tissue-preservation-for-bone-conduction-hearing-implants-a-multicenter-randomized-controlled-trial
#8
Tim G A Calon, Martin L Johansson, Arthur J G de Bruijn, Herbert van den Berge, Mariet Wagenaar, Edwin Eichhorn, Miranda M L Janssen, Janny R Hof, Jan-Wouter Brunings, Manuela A Joore, Sofia Jonhede, Joost van Tongeren, Marcus Holmberg, Robert-Jan Stokroos
OBJECTIVE: To compare the surgical outcomes of the Minimally Invasive Ponto Surgery (MIPS) technique with those of the linear incision technique with soft-tissue preservation for bone-anchored hearing systems (BAHS). DESIGN: Sponsor-initiated multicenter, open, randomized, controlled clinical trial. SETTING: Maastricht University Medical Centre, Ziekenhuisgroep Twente and Medisch Centrum Leeuwarden, all situated in The Netherlands. PARTICIPANTS: Sixty-four adult patients eligible for unilateral BAHS surgery...
August 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29985368/cochlear-implantation-in-the-guinea-pig
#9
Clemens Honeder, Navid Ahmadi, Anne-Margarethe Kramer, Chengjing Zhu, Nodir Saidov, Christoph Arnoldner
Cochlear implants are highly efficient devices that can restore hearing in subjects with profound hearing loss. Due to improved speech perception outcomes, candidacy criteria have been expanded over the last few decades. This includes patients with substantial residual hearing that benefit from electrical and acoustical stimulation of the same ear, which makes hearing preservation during cochlear implantation an important issue. Electrode impedances and the related issue of energy consumption is another major research field, as progress in this area could pave the way for fully implantable auditory prostheses...
June 15, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29971537/-hearing-preservation-in-children-with-electric-acoustic-stimulation-after-cochlear-implantation-outcome-after-electrode-insertion-with-minimal-insertion-trauma
#10
T Rader, A Bohnert, C Matthias, D Koutsimpelas, M-A Kainz, S Strieth
BACKGROUND: Cochlear implantation in patients with functional residual low-frequency hearing is performed according to an established hearing-preserving surgical technique in order to cause minimal trauma of inner ear structures. Due to the increasing number of cochlear implants in children, the preservation of residual hearing is becoming increasingly important in this patient collective. OBJECTIVES: Short- and mid-term hearing preservation outcome in pediatric patients is investigated...
July 3, 2018: HNO
https://www.readbyqxmd.com/read/29968098/reflection-and-distortion-source-otoacoustic-emissions-evidence-for-increased-irregularity-in-the-human-cochlea-during-aging
#11
Carolina Abdala, Amanda J Ortmann, Christopher A Shera
Previous research on distortion product otoacoustic emission (DPOAE) components has hinted at possible differences in the effect of aging on the two basic types of OAEs: those generated by a reflection mechanism in the cochlea and those created by nonlinear distortion (Abdala and Dhar in J Assoc Res Otolaryngol 13:403-421, 2012). This initial work led to the hypothesis that micromechanical irregularity ("roughness") increases in the aging cochlea, perhaps as the result of natural tissue degradation...
July 2, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29961654/stereotactic-radiotherapy-in-three-weekly-fractions-for-the-management-of-vestibular-schwannomas
#12
James A Gallogly, Mejd Jumaily, Farhoud Faraji, Anthony A Mikulec
PURPOSE: This study evaluates the rates of tumor control, hearing preservation and cranial nerve toxicity with the use of CyberKnife stereotactic radiotherapy consisting of 2100 cGy to the 80% isodose line delivered in three weekly fractions to treat vestibular schwannomas. MATERIALS AND METHODS: Retrospective chart review of vestibular schwannoma patients treated with CyberKnife stereotactic radiotherapy or undergoing watchful waiting between 2006 and 2017 was performed...
June 22, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29961377/safety-profile-of-superior-petrosal-vein-the-vein-of-dandy-sacrifice-in-neurosurgical-procedures-a-systematic-review
#13
Vinayak Narayan, Amey R Savardekar, Devi Prasad Patra, Nasser Mohammed, Jai D Thakur, Muhammad Riaz, Anil Nanda
OBJECTIVE Walter E. Dandy described for the first time the anatomical course of the superior petrosal vein (SPV) and its significance during surgery for trigeminal neuralgia. The patient's safety after sacrifice of this vein is a challenging question, with conflicting views in current literature. The aim of this systematic review was to analyze the current surgical considerations regarding Dandy's vein, as well as provide a concise review of the complications after its obliteration. METHODS A systematic review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
July 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29960491/a-binaural-auditory-steering-strategy-based-hearing-aid-algorithm-design
#14
Tobias Piechowiak, Changxue Ma, Rob de Vries, Andrew Dittberner
Beamforming techniques are widely used in hearing aids to enhance the intelligibility of speech from a target direction, but they tend to isolate the listener from their acoustic environment and distort spatial cues. The main reason for this is that a typical beamformer method alters the head-related transfer function of the individual users' ears and functions under monaural assumptions instead of a binaural model. In this letter, a binaural auditory steering strategy (BASS) is proposed for the design of asymmetrically presented spatial filters which improves awareness of the surrounding acoustic environment while preserving intelligibility from a target direction...
June 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29957681/comprehensive-review-of-the-extended-middle-cranial-fossa-approach
#15
Noga Lipschitz, Gavriel D Kohlberg, Mario Zuccarello, Ravi N Samy
PURPOSE OF REVIEW: To review the current literature on the extended middle cranial fossa (xMCF) approach and to provide a comprehensive description of the relevant anatomy, indications, surgical technique, results, and complications. RECENT FINDINGS: The xMCF approach expands the surgical exposure provided by the sMCF approach, allowing access to the internal auditory canal, cerebellopontine angle, prepontine cistern, anterior petrous apex, petrous carotid artery, Meckel's cave, cavernous sinus, mid and upper clivus, and posterior lesions approaching the jugular foramen...
June 27, 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29953049/-asymmetric-sensorineural-hearing-impairment-in-the-adult-population
#16
G Sh Tufatulin, M Yu Boboshko, S A Artyushkin
The relevance of the problem of a sensorineural hearing loss (ASNL) arises from the necessity of the special approaches to the diagnostics of this condition, the complications accompanying this pathology, and the difficulties encountered in the implementation of the methods designed for hearing rehabilitation of such patients. The objective of the present study was to estimate the prevalence of ASHL among the adult population. The sensorineural impairment of hearing was diagnosed in a total of 2456 (72%) examined patients presenting with hearing loss...
2018: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29940617/vestibular-sensory-functional-status-of-cochlear-implanted-ears-versus-non-implanted-ears-in-bilateral-profound-deaf-adults
#17
Romică Sebastian Cozma, Lucia Corina Dima-Cozma, Luminiţa Mihaela Rădulescu, Maria Cristina Hera, Cristian Mârţu, Raluca Olariu, Bogdan Mihail Cobzeanu, Oana Roxana Bitere, Mihail Dan Cobzeanu
Patients with hearing loss who underwent cochlear implantation can present symptomatic or asymptomatic vestibular damages earlier or later after the surgery. The vestibular permanent lesions could be acute, produced by surgical trauma or could be progressive due to local morphological changes made by the presence of the portelectrode in the inner ear (fibrosis related, ossification, basilar membrane distortion, endolymphatic hydrops). Besides histopathological findings in inner ear of cochlear implanted patients, the vestibular permanent damages could be found by assessment of clinical vestibular status...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29938519/hearing-preservation-after-translabyrinthine-vestibular-schwannoma-excision-audiometry-and-electrocochleography-results
#18
Kenneth Akakpo, William J Riggs, Michael S Harris, Edward E Dodson
OBJECTIVES: To describe a case of inadvertent hearing preservation following a classical translabyrinthine resection of a vestibular schwannoma of the internal auditory canal in an otherwise healthy patient. METHODS: Herein, we describe the case of an otherwise healthy patient who underwent resection of an intracanalicular vestibular schwannoma via a translabyrinthine approach. Furthermore, as part of an ongoing study aimed at characterizing hearing changes due to intraoperative events, cochlear hair cell and nerve activity were monitored using electrocochleography throughout surgery...
June 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29937713/cognitive-decline-dementia-alzheimer-s-disease-and-presbycusis-examination-of-the-possible-molecular-mechanism
#19
REVIEW
Yilin Shen, Bin Ye, Penghui Chen, Quan Wang, Cui Fan, Yilai Shu, Mingliang Xiang
The incidences of presbycusis and dementia are high among geriatric diseases. Presbycusis is the general term applied to age-related hearing loss and can be caused by many risk factors, such as noise exposure, smoking, medication, hypertension, family history, and other factors. Mutation of mitochondrial DNA in hair cells, spiral ganglion cells, and stria vascularis cells of the cochlea is the basic mechanism of presbycusis. Dementia is a clinical syndrome that includes the decline of cognitive and conscious states and is caused by many neurodegenerative diseases, of which Alzheimer's disease (AD) is the most common...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29929725/contralateral-sensorineural-hearing-loss-after-vestibular-schwannoma-surgery
#20
Patricia García-Cabo, Fernando Rivas, Fernando López, Andrés Coca, José Luis Llorente, Justo R Gómez
INTRODUCTION: Contralateral sensorineural hearing loss (CSNHL) after vestibular schwannoma (VS) is a severe complication, especially in those cases in which hearing preservation in the operated side was not possible. There are several theories that attempt to explain this issue, but there is no established guideline of treatment. MATERIAL AND METHODS: We report 4 patients treated in our institution who developed a severe CSNHL after surgery. RESULTS: Of the 185 cases of VS treated with surgery, 4 patients (2...
June 18, 2018: Acta Otorrinolaringológica Española
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