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Hearing Preservation

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https://www.readbyqxmd.com/read/28527538/masking-release-with-changing-fundamental-frequency-electric-acoustic-stimulation-resembles-normal-hearing-subjects
#1
Alice Barbara Auinger, Dominik Riss, Rudolfs Liepins, Tobias Rader, Tilman Keck, Thomas Keintzel, Alexandra Kaider, Wolf-Dieter Baumgartner, Wolfgang Gstoettner, Christoph Arnoldner
It has been shown that patients with electric acoustic stimulation (EAS) perform better in noisy environments than patients with a cochlear implant (CI). One reason for this could be the preserved access to acoustic low-frequency cues including the fundamental frequency (F0). Therefore, our primary aim was to investigate whether users of EAS experience a release from masking with increasing F0 difference between target talker and masking talker. The study comprised 29 patients and consisted of three groups of subjects: EAS users, CI users and normal-hearing listeners (NH)...
May 11, 2017: Hearing Research
https://www.readbyqxmd.com/read/28516364/preserving-normal-facial-nerve-function-and-improving-hearing-outcome-in-large-vestibular-schwannomas-with-a-combined-approach-planned-subtotal-resection-followed-by-gamma-knife-radiosurgery
#2
Roy Thomas Daniel, Constantin Tuleasca, Mercy George, Etienne Pralong, Luis Schiappacasse, Michele Zeverino, Raphael Maire, Marc Levivier
OBJECTIVE: To perform planned subtotal resection followed by gamma knife surgery (GKRS) in a series of patients with large vestibular schwannoma (VS), aiming at an optimal functional outcome for facial and cochlear nerves. METHODS: Patient characteristics, surgical and dosimetric features, and outcome were collected prospectively at the time of treatment and during the follow-up. RESULTS: A consecutive series of 32 patients was treated between July 2010 and June 2016...
May 17, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28513246/molecular-composition-and-distribution-of-gap-junctions-in-the-sensory-epithelium-of-the-human-cochlea-a-super-resolution-structured-illumination-microscopy-sr-sim-study
#3
Wei Liu, Hao Li, Fredrik Edin, Johan Brännström, Rudolf Glueckert, Annelies Schrott-Fischer, Matyas Molnar, Dirk Pacholsky, Kristian Pfaller, Helge Rask-Andersen
BACKGROUND: Mutations in the GJB2 gene, which encodes the Connexin26 (Cx26) protein, are the most common cause of childhood hearing loss in American and European populations. The cochlea contains a gap junction (GJ) network in the sensory epithelium and two connective tissue networks in the lateral wall and spiral limbus. The syncytia contain the GJ proteins beta 2 (GJB2/Cx26) and beta 6 (GJB6/Cx30). Our knowledge of their expression in humans is insufficient due to the limited availability of tissue...
May 17, 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28502566/lateral-skull-base-chondroblastoma-resected-with-facial-nerve-posterior-transposition
#4
J Adnot, O Langlois, E Tollard, M Crahes, I Auquit-Auckbur, J-P Marie
INTRODUCTION: Chondroblastoma is a rare tumor that can involve the temporal bone. Because it is a benign tumor, functional surgery must be proposed. We report a case of a patient with a massive chondroblastoma operated on with preservation of the facial nerve, and description of the surgical technique. CASE PRESENTATION: A 37-year-old man presented with a 9-month history of a growing left pre-auricular mass and hearing loss. Neuroimaging showed an osteolytic mass invading the temporal bone and temporomandibular joint...
May 11, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28499298/-cochlear-implant-state-of-the-art
#5
Thomas Lenarz
Cochlear implants are the treatment of choice for the auditory rehabilitation of patients with sensory deafness. They restore the missing function of inner hair cells by transforming the acoustic signal into electrical stimuli for activation of auditory nerve fibers. Due to the very fast technology development cochlear implants provide open-set speech understanding in the majority of patients including the use of the telephone. Children can achieve a near to normal speech and language development provided their deafness is detected early after onset and implantation is performed quickly thereafter...
April 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28498265/the-effect-of-systemic-steroid-on-hearing-preservation-after-cochlear-implantation-via-round-window-approach-a-guinea-pig-model
#6
Mun Young Chang, Yoon Chan Rah, Jun Jae Choi, Shin Wook Woo, Yu-Jung Hwang, Hayden Eastwood, Stephen J O'Leary, Jun Ho Lee
HYPOTHESIS: When administered perioperatively, systemic dexamethasone will reduce the hearing loss associated with cochlear implantation (CI) performed via the round window approach. BACKGROUND: The benefits of electroacoustic stimulation have led to interest in pharmacological interventions to preserve hearing after CI. METHODS: Thirty guinea pigs were randomly divided into three experimental groups: a control group; a 3-day infusion group; and a 7-day infusion group...
May 11, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28492547/autophagy-is-essential-for-hearing-in-mice
#7
Chisato Fujimoto, Shinichi Iwasaki, Shinji Urata, Hideaki Morishita, Yuriko Sakamaki, Masato Fujioka, Kenji Kondo, Noboru Mizushima, Tatsuya Yamasoba
Hearing loss is the most frequent sensory disorder in humans. Auditory hair cells (HCs) are postmitotic at late-embryonic differentiation and postnatal stages, and their damage is the major cause of hearing loss. There is no measurable HC regeneration in the mammalian cochlea, and the maintenance of cell function is crucial for preservation of hearing. Here we generated mice deficient in autophagy-related 5 (Atg5), a gene essential for autophagy, in the HCs to investigate the effect of basal autophagy on hearing acuity...
May 11, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28490377/cochlear-implant-electrode-sealing-techniques-and-related-intracochlear-pressure-changes
#8
Ingo Todt, Julica Utca, Dania Karimi, Arne Ernst, Philipp Mittmann
BACKGROUND: The inserted cochlear implanted electrode is covered at the site of the round window or cochleostomy to prevent infections and leakage. In a surgically hearing preservational concept, low intracochlear pressure changes are of high importance. The aim of this study was to observe intracochlear pressure changes due to different sealing techniques in a cochlear model. METHODS: Cochlear implant electrode insertions were performed in an artifical cochlear model and the intracochlear pressure changes were recorded in parallel with a micro-pressure sensor positioned in the apical region of the cochlea model to follow the maximum amplitude of intracochlear pressure...
May 11, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28485635/bimodal-benefits-in-mandarin-speaking-cochlear-implant-users-with-contralateral-residual-acoustic-hearing
#9
Hsin-I Yang, Fan-Gang Zeng
OBJECTIVE: The present study aimed to measure bimodal benefits and probe their underlying mechanisms in Mandarin-speaking cochlear implant (CI) subjects who had contralateral residual acoustic hearing. DESIGN: The subjects recognised words or phonemes from the Mandarin Lexical Neighborhood Test in noise at a 10-dB signal-to-noise ratio (SNR) with acoustic stimulation, electric stimulation or the combined bimodal stimulation. STUDY SAMPLE: Thirteen Mandarin-speaking subjects wore a CI in one ear and had residual acoustic hearing in the contralateral ear...
May 9, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28480107/clinical-features-microsurgical-treatment-and-outcome-of-vestibular-schwannoma-with-brainstem-compression
#10
Ali Harati, Kai-Michael Scheufler, Rolf Schultheiss, Albaraa Tonkal, Kamran Harati, Paul Oni, Thomas Deitmer
BACKGROUND: Presenting symptoms, treatment considerations, and outcome are strongly related to the extension of vestibular schwannomas (VS). The aim of the current retrospective study was to analyze the clinical features, microsurgical treatment, and outcome of VS with brainstem compression. METHODS: Forty-nine patients presented with VS (Hannover grading scale T4a or T4b) in our department. A subgroup analysis was performed among patients without (T4a) and with (T4b) compression and dislocation of the fourth ventricle...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28477092/-intracochlear-schwannoma-tumor-removal-via-subtotal-cochleostomy-and-partial-cochlear-reconstruction-with-preservation-of-semicircular-canal-function-german-version
#11
S Plontke, S Kösling, N Pazaitis, T Rahne
We report about a patient who in 2005, aged 37 years, experienced sudden mild to moderate, mid-frequency sensorineural hearing loss in the right ear along with tinnitus and mild dizziness. MRI of the temporal bone revealed a very small (1 mm) contrast-enhancing lesion in the second turn of the right cochlea. Hearing gradually deteriorated with complete hearing loss in 2015. At this time, an MRI scan showed a lesion completely filling the cochlea.The tumor was removed via transmeatal subtotal cochleostomy...
May 5, 2017: HNO
https://www.readbyqxmd.com/read/28464692/effects-of-hearing-aid-dynamic-range-compression-on-spatial-perception-in-a-reverberant-environment
#12
Henrik Gert Hassager, Alan Wiinberg, Torsten Dau
This study investigated the effects of fast-acting hearing-aid compression on normal-hearing and hearing-impaired listeners' spatial perception in a reverberant environment. Three compression schemes-independent compression at each ear, linked compression between the two ears, and "spatially ideal" compression operating solely on the dry source signal-were considered using virtualized speech and noise bursts. Listeners indicated the location and extent of their perceived sound images on the horizontal plane...
April 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28464637/the-effect-of-tone-vocoding-on-spatial-release-from-masking-for-old-hearing-impaired-listeners
#13
Andrew King, Kathryn Hopkins, Christopher J Plack, Niels Henrik Pontoppidan, Lars Bramsløw, Renskje K Hietkamp, Marianna Vatti, Atefeh Hafez
Old, hearing-impaired listeners generally benefit little from lateral separation of multiple talkers when listening to one of them. This study aimed to determine how spatial release from masking (SRM) in such listeners is affected when the interaural time differences (ITDs) in the temporal fine structure (TFS) are manipulated by tone-vocoding (TVC) at the ears by a master hearing aid system. Word recall was compared, with and without TVC, when target and masker sentences from a closed set were played simultaneously from the front loudspeaker (co-located) and when the maskers were played 45° to the left and right of the listener (separated)...
April 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28464634/sound-localization-models-as-evaluation-tools-for-tactical-communication-and-protective-systems
#14
Thomas Joubaud, Véronique Zimpfer, Alexandre Garcia, Christophe Langrenne
Tactical Communication and Protective Systems (TCAPS) are hearing protection devices that sufficiently protect the listener's ears from hazardous sounds and preserve speech intelligibility. However, previous studies demonstrated that TCAPS still deteriorate the listener's situational awareness, in particular, the ability to locate sound sources. On the horizontal plane, this is mainly explained by the degradation of the acoustical cues normally preventing the listener from making front-back confusions. As part of TCAPS development and assessment, a method predicting the TCAPS-induced degradation of the sound localization capability based on electroacoustic measurements would be more suitable than time-consuming behavioral experiments...
April 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28443060/the-vestibular-implant-hearing-preservation-during-intralabyrinthine-electrode-insertion-a-case-report
#15
Raymond van de Berg, Florence Lucieer, Nils Guinand, Joost van Tongeren, Erwin George, Jean-Philippe Guyot, Herman Kingma, Marc van Hoof, Yasin Temel, Jacobus van Overbeeke, Angelica Perez-Fornos, Robert Stokroos
OBJECTIVE: The vestibular implant seems feasible as a clinically useful device in the near future. However, hearing preservation during intralabyrinthine implantation remains a challenge. It should be preserved to be able to treat patients with bilateral vestibulopathy and (partially) intact hearing. This case study investigated the feasibility of hearing preservation during the acute phase after electrode insertion in the semicircular canals. METHODS: A 40-year-old woman with normal hearing underwent a translabyrinthine approach for a vestibular schwannoma Koos Grade IV...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28441508/cyberknife-for-treatment-of-vestibular-schwannoma-a-meta-analysis
#16
Hossein Mahboubi, Ronald Sahyouni, Omid Moshtaghi, Kent Tadokoro, Yaser Ghavami, Kasra Ziai, Harrison W Lin, Hamid R Djalilian
Objectives (1) Perform a meta-analysis of the available data on the outcomes of CyberKnife radiosurgery for treatment of vestibular schwannomas (VSs) in the published English-language literature and (2) evaluate the collective outcomes of CyberKnife treatment with respect to tumor control and hearing preservation. Data Sources A thorough literature search of published English-language articles was performed in the PubMed, Ovid, and Cochrane databases. Review Methods A database search was conducted with the keywords "CyberKnife" and "vestibular schwannoma" or "acoustic neuroma...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28432874/delayed-changes-in-auditory-status-in-cochlear-implant-users-with-preserved-acoustic-hearing
#17
Rachel A Scheperle, Viral D Tejani, Julia K Omtvedt, Carolyn J Brown, Paul J Abbas, Marlan R Hansen, Bruce J Gantz, Jacob J Oleson, Marie V Ozanne
This retrospective review explores delayed-onset hearing loss in 85 individuals receiving cochlear implants designed to preserve acoustic hearing at the University of Iowa Hospitals and Clinics between 2001 and 2015. Repeated measures of unaided behavioral audiometric thresholds, electrode impedance, and electrically evoked compound action potential (ECAP) amplitude growth functions were used to characterize longitudinal changes in auditory status. Participants were grouped into two primary categories according to changes in unaided behavioral thresholds: (1) stable hearing or symmetrical hearing loss and (2) delayed loss of hearing in the implanted ear...
April 12, 2017: Hearing Research
https://www.readbyqxmd.com/read/28432353/severe-hearing-loss-and-outer-hair-cell-death-in-homozygous-foxo3-knockout-mice-after-moderate-noise-exposure
#18
Felicia Gilels, Stephen T Paquette, Holly J Beaulac, Anwen Bullen, Patricia M White
Noise induced hearing loss (NIHL) is a disease that affects millions of Americans. Identifying genetic pathways that influence recovery from noise exposure is an important step forward in understanding NIHL. The transcription factor Foxo3 integrates the cellular response to oxidative stress and plays a role in extending lifespan in many organisms, including humans. Here we show that Foxo3 is required for auditory function after noise exposure in a mouse model system, measured by ABR. Absent Foxo3, outer hair cells are lost throughout the middle and higher frequencies...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428227/mechanisms-in-endocrinology-the-multiple-facets-of-gh-lessons-from-lifetime-untreated-isolated-gh-deficiency-due-to-ghrh-receptor-mutation
#19
Manuel Aguiar-Oliveira, Anita Ho Souza, Carla R Oliveira, Viviane C Campos, Luiz A Oliveira-Neto, Roberto Salvatori
Twenty years ago, we described a kindred of 105 individuals with isolated GH deficiency (IGHD) in Itabaianinha County, in Brazilian northeast, due to a homozygous mutation in the GH-releasing hormone receptor gene. These subjects exhibit markedly reduced GH responsiveness to stimulatory tests, and anterior pituitary hypoplasia. Serum concentrations of IGF-I, IGF binding protein type 3, and the acid-labile subunit are markedly reduced, with a lesser reduction of IGF-II. The most striking physical findings of these IGHD individuals are the proportionate short stature, doll facies, high-pitched voice, and visceral obesity with reduced fat free mass...
April 20, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28427410/long-term-follow-up-after-stereotactic-radiosurgery-of-intracanalicular-acoustic-neurinoma
#20
Daniel Rueß, Lea Pöhlmann, Stefan Grau, Christina Hamisch, Alexandra Hellerbach, Harald Treuer, Martin Kocher, Maximilian I Ruge
BACKGROUND: The management of solely intracanalicular acoustic neurinoma (iAN) includes observation, microsurgical resection and radiation therapy. Treatment goals are long-term tumor control, hearing preservation and concurrently low side-effects. Stereotactic radiosurgery (SRS) has evolved as an alternative first-line treatment for small AN. Here we report about the long-term follow-up of a unique cohort of patients with iAN after LINAC or Cyberknife® based SRS. METHODS: In this single center retrospective analysis, we included all patients with iAN who underwent single session LINAC or Cyberknife® based SRS between 1993 and 2015, and who had a minimum follow-up period of six weeks...
April 21, 2017: Radiation Oncology
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