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Hearing Preservation

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https://www.readbyqxmd.com/read/28647848/the-utilization-of-round-window-membrane-surface-tension-in-facilitating-slim-electrodes-insertion-during-cochlear-implantation
#1
Ihab Nada, Ahmed Nabil Abdelhamid, Ahmed Negm
This is a prospective randomized study aimed to evaluate the round window membrane (RWM) surface tension in facilitating slim electrodes insertion during cochlear implantation. A total number of (118) children were included in this study (118 implantations). Mean age was 36.72 months (range from 18 to 60 months). This study was conducted from January 2015 to September 2016 at a cochlear implant centre in a tertiary referral hospital. Slit incision in the anterosuperior quadrant of the RWM was done in 70 cases, While RWM cruciate incision was done in 48 cases...
June 24, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28646272/rhesus-cochlear-and-vestibular-functions-are-preserved-after-inner-ear-injection-of-saline-volume-sufficient-for-gene-therapy-delivery
#2
Chenkai Dai, Mohamed Lehar, Daniel Q Sun, Lani Swarthout Rvt, John P Carey, Tim MacLachlan, Doug Brough, Hinrich Staecker, Alexandra M Della Santina, Timothy E Hullar, Charles C Della Santina
Sensorineural losses of hearing and vestibular sensation due to hair cell dysfunction are among the most common disabilities. Recent preclinical research demonstrates that treatment of the inner ear with a variety of compounds, including gene therapy agents, may elicit regeneration and/or repair of hair cells in animals exposed to ototoxic medications or other insults to the inner ear. Delivery of gene therapy may also offer a means for treatment of hereditary hearing loss. However, injection of a fluid volume sufficient to deliver an adequate dose of a pharmacologic agent could, in theory, cause inner ear trauma that compromises functional outcome...
June 23, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28643327/predictive-factors-for-short-and-long-term-hearing-preservation-in-cochlear-implantation-with-conventional-length-electrodes
#3
George B Wanna, Brendan P O'Connell, David O Francis, Rene H Gifford, Jacob B Hunter, Jourdan T Holder, Marc L Bennett, Alejandro Rivas, Robert F Labadie, David S Haynes
OBJECTIVES/HYPOTHESIS: The aims of this study were to investigate short- and long-term rates of hearing preservation after cochlear implantation and identify factors that impact hearing preservation. STUDY DESIGN: Retrospective review. METHODS: Patients undergoing cochlear implantation with conventional-length electrodes and air-conduction thresholds ≤80 dB HL at 250 Hz preoperatively were included. Hearing preservation was defined as air-conduction thresholds ≤80 dB HL at 250 Hz...
June 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28616773/intracochlear-schwannoma-tumor-removal-via-subtotal-cochleoectomy-and-partial-cochlear-reconstruction-with-preservation-of%C3%A2-semicircular-canal-function
#4
S K Plontke, S Kösling, N Pazaitis, T Rahne
We report about a patient, who in 2005, as a 37-year-old, experienced a sudden, mild to moderate, mid-frequency sensorineural hearing loss in the right ear, along with tinnitus and mild dizziness. MRI of the temporal bone revealed a very small (1 mm) enhancing lesion in the second turn of the right cochlea after injection of contrast medium. Hearing gradually deteriorated, with complete hearing loss in 2015. At this time, an MRI scan showed a lesion completely filling the cochlea.The tumor was removed through a subtotal cochleoectomy...
June 14, 2017: HNO
https://www.readbyqxmd.com/read/28615657/bone-morphogenetic-protein-4-promotes-the-survival-and-preserves-the-structure-of-flow-sorted-bhlhb5-cochlear-spiral-ganglion-neurons-in-vitro
#5
Muhammad Waqas, Shan Sun, Chuanyin Xuan, Qiaojun Fang, Xiaoli Zhang, Irum-Us Islam, Jieyu Qi, Shasha Zhang, Xia Gao, Mingliang Tang, Haibo Shi, Huawei Li, Renjie Chai
SGNs are the primary auditory neurons, and damage or loss of SGNs leads to sensorineural hearing loss. BMP4 is a growth factor that belongs to the TGF-β superfamily and has been shown to play a key role during development, but little is known about its effect on postnatal cochlear SGNs in mice. In this study, we used the P3 Bhlhb5-cre/tdTomato transgenic mouse model and FACS to isolate a pure population of Bhlhb5+ SGNs. We found that BMP4 significantly promoted SGN survival after 7 days of culture. We observed fewer apoptotic cells and decreased expression of pro-apoptotic marker genes after BMP4 treatment...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28611574/intra-and-postoperative-electrocochleography-may-be-predictive-of-final-electrode-position-and-postoperative-hearing-preservation
#6
Brendan P O'Connell, Jourdan T Holder, Robert T Dwyer, René H Gifford, Jack H Noble, Marc L Bennett, Alejandro Rivas, George B Wanna, David S Haynes, Robert F Labadie
Introduction: The objectives of the current study were to (1) determine the relationship between electrocochleography (ECochG), measured from the cochlear implant (CI) electrode array during and after implantation, and postoperative audiometric thresholds, (2) determine the relationship between ECochG amplitude and electrode scalar location determined by computerized tomography (CT); and (3) determine whether changes in cochlear microphonic (CM) amplitude during electrode insertion were associated with postoperative hearing...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28608735/hearing-preservation-does-electrode-choice-matter
#7
Leila J Mady, Daniel C Sukato, Jenifer Fruit, Catherine Palmer, Yael Raz, Barry E Hirsch, Andrew A McCall
Objective Evaluate if electrode design affects hearing preservation (HP) following cochlear implantation (CI) with full-length electrodes. Study Design Case series with chart review. Setting Tertiary referral academic center. Subjects and Methods Forty-five adults with low-frequency hearing (≤85 dB at 250 and 500 Hz) who underwent unilateral CI with full-length electrode arrays made by 1 manufacturer were included. HP was calculated with (1) mean low-frequency pure-tone average (LFPTA) at 250 and 500 Hz (MEAN method), (2) a percentile method across the audiometric frequency spectrum generating an S-value (HEARRING method), and (3) functional if hearing remained ≤85 dB at 250 and 500 Hz...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28607891/cholesteatoma-induced-labyrinthine-fistula-is-aggressiveness-in-removing-disease-justified
#8
Prem Sagar, K Devaraja, Rajeev Kumar, Sumanth Bolu, Suresh C Sharma
Issues of complete disease clearance and hearing preservation in cholesteatoma induced labyrinthine fistula cases has been discussed and updated in this article. Successful disease clearance and hearing preservation in a case of cholesteatoma induced isolated cochlear promontory fistula encouraged us to retrospectively analyse 13 more cases of cholesteatoma induced labyrinthine fistula who presented in emergency service as complicated chronic suppurtive otitis media. Pre-operatively nine patients experienced vertigo, two had profound sensori neural hearing loss and radiology was suggestive of labyrinthine fistula in 12 patients...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28607880/role-of-autologous-versus-homologous-cartilage-in-ossicular-reconstruction-a-comparative-study
#9
Karan Sharma, Pratibha Gururani, Archana Arora, Gagandeep Singh
Ossicular discontinuity is the most common cause of conductive hearing loss. The use of ossicular graft material in ossicular chain reconstruction significantly improves the result in hearing. This study was conducted to compare and analyze the outcome of ossicular reconstruction using autologous conchal cartilage and homologous septal cartilage in terms of hearing results and graft uptake rates. Study design Randomized clinical trial. Study included 100 patients visiting the ENT department of government medical college...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28602150/translabyrinthine-vestibular-schwannoma-resection-with-simultaneous-cochlear-implantation
#10
Austin N DeHart, William C Broaddus, Daniel H Coelho
OBJECTIVES: (1) Report a rare case of translabyrinthine resection of a sporadic vestibular schwannoma (VS) and concurrent cochlear implantation (CI). (2) Discuss pre-, intra-, and post-operative considerations in this unique patient population. (3) Describe surgical and audiologic outcomes reported in this population. METHODS: Case report and review of the literature. PubMed search 'Cochlear Implantation'[Mesh] AND ('Neuroma, Acoustic'[Mesh] OR 'VESTIBULAR SCHWANNOMA'[All Fields] OR 'SCHWANNOMA'[All Fields]) limited to humans and English language...
June 12, 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28589468/optimal-treatment-of-jugular-foramen-schwannomas-long-term-outcome-of-a-multidisciplinary-approach-for-a-series-of-29-cases-in-a-single-institute
#11
Sung Mo Ryu, Jung-Il Lee, Kwan Park, Jung Won Choi, Doo-Sik Kong, Do-Hyun Nam, Han-Shin Jeong, Yang-Sun Cho, Ho Jun Seol
BACKGROUND: The goal of treatment for jugular foramen schwannomas (JFSs) is to achieve complete tumor removal with cranial nerve preservation. However, achieving this goal remains a challenge despite the advances in microsurgical techniques. The aim of this study was to determine optimal treatment strategies for JFSs based on a review of a series of 29 surgical cases in our institute. MATERIALS AND METHODS: Between 1997 and 2013, 29 patients with JFSs underwent surgical treatment by multidisciplinary otoneurosurgical approaches...
June 6, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28589320/impact-of-the-round-window-membrane-accessibility-on-hearing-preservation-in-adult-cochlear-implantation
#12
Marjan Mirsalehi, Saleh Mohebbi, Mahsa Ghajarzadeh, Thomas Lenarz, Omid Majdani
This study was conducted to evaluate the effect of the round window membrane accessibility on the residual hearing after cochlear implantation surgery in adults. Moreover, the effects of the other demographics and intra-operative factors on the residual hearing loss have been evaluated. The hearing preservation cochlear implantation surgery was performed on 64 adults with residual hearing thresholds ≤80 dB at 250 and 500 Hz, who had referred to our tertiary academic center. All the patients underwent a standardized surgical approach with the same straight electrode inserted through the round window membrane...
June 6, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28589319/the-transotic-approach-for-vestibular-schwannoma-indications-and-results
#13
Yin Xia, Wenyang Zhang, Yi Li, Xiaobo Ma, Qiang Liu, Jinghua Shi
To analyze retrospectively the indications and the results obtained with the transotic approach in a series of patients with vestibular schwannoma. The study included 36 patients from 2007 to 2013 with a vestibular schwannoma that was removed with a transotic approach. All patients underwent preoperative pure tone audiometry, evaluation of facial function and CT and MR imaging. All patients having (1) a hearing loss of more than 50 dB, (2) an average tumor size of 2.7 cm (range 0.5-5.0 cm) and (3) signs of a contracted mastoid (high jugular bulb, anteriorly located sigmoid sinus, low middle cranial fossa, or reduced pneumatization) were selected...
June 6, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28555839/promotion-of-endocytosis-efficiency-through-an-atp-independent-mechanism-at-rat-calyx-of-held-terminals
#14
Hai-Yuan Yue, Erhard Bieberich, Jianhua Xu
Neurotransmission relies on membrane endocytosis to maintain vesicle supply and membrane stability. Endocytosis has been generally recognized as a major ATP-dependent function, which efficiently retrieves more membrane at elevated neuronal activity when ATP consumption within nerve terminals drastically increases. This paradox raises an interesting question whether increased activity recruits ATP-independent mechanism(s) to accelerate endocytosis while preserving ATP availability for other tasks. To address this issue, we studied ATP requirement in three typical forms of endocytosis at the rat calyx of Held terminals by whole-cell membrane capacitance measurements...
May 29, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28555602/efficacy-of-directional-microphones-in-hearing-aids-equipped-with-wireless-synchronization-technology
#15
Chinnaraj Geetha, Kishore Tanniru, R Raja Rajan
OBJECTIVE: This study aimed to evaluate the use of directionality in hearing aids with wireless synchronization on localization and speech intelligibility in noise. MATERIALS AND METHODS: This study included 25 individuals with bilateral mild to moderate flat sensorineural hearing loss. For the localization experiment, eight loudspeakers (Genelec 8020B) arranged in a circle covering a 0-360° angle and the Cubase 6 software were used for presenting the stimulus...
April 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28538468/hearing-preservation-in-pediatric-cochlear-implantation
#16
Matthew L Carlson, Neil S Patel, Nicole M Tombers, Melissa D DeJong, Alyce I Breneman, Brian A Neff, Colin L W Driscoll
OBJECTIVE: Currently, there is a paucity of literature evaluating hearing preservation outcomes in children following cochlear implantation. The objective of the current study is to report pediatric hearing preservation results following cochlear implantation with conventional full-length electrodes. STUDY DESIGN: Retrospective review (2000-2016). SETTING: Tertiary referral center. PATIENTS: All pediatric patients with a ≤ 75 dB preoperative low-frequency pure tone average (LFPTA; 250-500 Hz average), who underwent cochlear implantation with a conventional length electrode...
July 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28536486/emerging-indications-for-fractionated-gamma-knife-radiosurgery
#17
Emory McTyre, Corbin A Helis, Michael Farris, Lisa Wilkins, Darrell Sloan, William H Hinson, J Daniel Bourland, William A Dezarn, Michael T Munley, Kounosuke Watabe, Fei Xing, Adrian W Laxton, Stephen B Tatter, Michael D Chan
BACKGROUND: Gamma Knife radiosurgery (GKRS) allows for the treatment of intracranial tumors with a high degree of dose conformality and precision. There are, however, certain situations wherein the dose conformality of GKRS is desired, but single session treatment is contraindicated. In these situations, a traditional pin-based GKRS head frame cannot be used, as it precludes fractionated treatment. OBJECTIVE: To report our experience in treating patients with fractionated GKRS using a relocatable, noninvasive immobilization system...
February 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28534729/self-selection-of-frequency-tables-with-bilateral-mismatches-in-an-acoustic-simulation-of-a-cochlear-implant
#18
Matthew B Fitzgerald, Ksenia Prosolovich, Chin-Tuan Tan, E Katelyn Glassman, Mario A Svirsky
BACKGROUND: Many recipients of bilateral cochlear implants (CIs) may have differences in electrode insertion depth. Previous reports indicate that when a bilateral mismatch is imposed, performance on tests of speech understanding or sound localization becomes worse. If recipients of bilateral CIs cannot adjust to a difference in insertion depth, adjustments to the frequency table may be necessary to maximize bilateral performance. PURPOSE: The purpose of this study was to examine the feasibility of using real-time manipulations of the frequency table to offset any decrements in performance resulting from a bilateral mismatch...
May 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28534710/systematic-review-radiological-and-histological-evidence-of-cochlear-implant-insertion-trauma-in-adult-patients
#19
Emma Hoskison, Scott Mitchell, Chris Coulson
INTRODUCTION: Cochlear implantation (CI) has developed from its origins in the 1980s. Initially, CI was for profound bilateral hearing impairment. However, candidacy for CI have become more widespread in recent years with unilateral implantation and an emphasis on hearing preservation. Evidence supports full electrode insertion in an atraumatic fashion into the scala tympani (ST) provides optimal hearing outcomes. The main aim of this systematic review was to elucidate the degree of trauma associated with CI insertion...
May 23, 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28527538/masking-release-with-changing-fundamental-frequency-electric-acoustic-stimulation-resembles-normal-hearing-subjects
#20
Alice Barbara Auinger, Dominik Riss, Rudolfs Liepins, Tobias Rader, Tilman Keck, Thomas Keintzel, Alexandra Kaider, Wolf-Dieter Baumgartner, Wolfgang Gstoettner, Christoph Arnoldner
It has been shown that patients with electric acoustic stimulation (EAS) perform better in noisy environments than patients with a cochlear implant (CI). One reason for this could be the preserved access to acoustic low-frequency cues including the fundamental frequency (F0). Therefore, our primary aim was to investigate whether users of EAS experience a release from masking with increasing F0 difference between target talker and masking talker. The study comprised 29 patients and consisted of three groups of subjects: EAS users, CI users and normal-hearing listeners (NH)...
May 11, 2017: Hearing Research
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