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Thyroid autoimmunity

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https://www.readbyqxmd.com/read/28219801/ala-photodynamic-treatment-in-lichen-sclerosus-clinical-and-immunological-outcome-focusing-on-the-assesment-of-anti-nuclear-antibodies
#1
Anita Olejek, Iwona Gabriel, Anna Bilska-Janosik, Iwona Kozak-Darmas, Aleksandra Kawczyk-Krupka
BACKGROUND: Lichen sclerosus (LS) is a difficult to treat, often relapsing disease with unknown background. An autoimmune diseases coexist with LS. Over recent years photodynamic therapy (PDT) has been shown to be noninvasive and successful therapeutic approach for the effective treatment many conditions. However, the change of immune status of the patients based on ANA antibodies has not been yet reported. Our aim was to observe the clinical response followed by possible changes in autoimmune antibodies levels before and after PDT...
February 17, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28217973/unravelling-thyroid-dysfunction-in-rheumatoid-arthritis-history-matters
#2
Joseph Anoop, Francis Geetha, Idiculla Jyothi, Pradeep Rekha, Vineeta Shobha
AIM: Autoimmune thyroid disease (AITD) frequently coexists with other systemic autoimmune conditions such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Due to the overlapping and nonspecific nature of symptoms, it is difficult to clinically uncover thyroidal illnesses in RA patients. This study was conducted to estimate the prevalence of thyroid dysfunction including the presence of anti-thyroid peroxidase (antiTPO) autoantibodies in patients with RA and to analyze symptomatology of thyroid dysfunction in patients diagnosed with RA...
February 20, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28217937/evidence-for-the-association-of-hashimoto-s-thyroiditis-with-psoriasis-a-cross-sectional-retrospective-study
#3
Tina Kiguradze, Finola M Bruins, Nicholas Guido, Tanya Bhattacharya, Alfred Rademaker, Aleksandra G Florek, Alba Posligua, Shatil Amin, Anne E Laumann, Dennis P West, Beatrice Nardone
BACKGROUND: Current information indicates that psoriasis is a metabolic disorder with systemic manifestations. Reports have revealed an association between psoriasis and several chronic autoimmune disorders. For one of these disorders, Hashimoto's thyroiditis (HT), there are scarce, and relatively unconfirmed, reports of an association with psoriasis. We sought to determine if such an association is detectable in a large medical record data repository. METHODS: We searched one institution's electronic medical record data repository from January 2010 to December 2013...
February 19, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28217504/improving-iodine-nutritional-status-and-increasing-prevalence-of-autoimmune-thyroiditis-in-children
#4
Srinivasan Palaniappan, Lakshmi Shanmughavelu, Hemchand K Prasad, Sundari Subramaniam, Nedunchezian Krishnamoorthy, Lakshmi Lakkappa
OBJECTIVE: The objective of this study is to evaluate the link between excess iodine intake as evidenced by increased urinary iodine excretion (UIE) and autoimmune thyroiditis in children and to assess the correlation between UIE and thyroid microsomal antibody (thyroid peroxidase [TPO]) titers in children. MATERIALS AND METHODS: All children with goiter between age group 6 and 12 years, were subjected to blood tests for free thyroxine, thyroid stimulating hormone, and TPO antibody, fine needle aspiration was advised for all children with goiter...
January 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28216655/a-novel-thymoma-associated-autoimmune-disease-anti-pit-1-antibody-syndrome
#5
Hironori Bando, Genzo Iguchi, Yasuhiko Okimura, Yukiko Odake, Kenichi Yoshida, Ryusaku Matsumoto, Kentaro Suda, Hitoshi Nishizawa, Hidenori Fukuoka, Atsuko Mokubo, Katsuyoshi Tojo, Yoshimasa Maniwa, Wataru Ogawa, Yutaka Takahashi
Anti-PIT-1 antibody syndrome has recently been reported and characterized by acquired growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) deficiencies associated with autoimmunity to a pituitary specific transcription factor PIT-1, which plays an essential role in GH-, PRL-, and TSH-producing cells. Although circulating anti-PIT-1 antibody and PIT-1-reactive cytotoxic T cells (CTLs) were detected in the patients, the pathophysiology and precise mechanisms for the autoimmunity remain unclarified...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216261/modulating-the-function-of-the-immune-system-by-thyroid-hormones-and-thyrotropin
#6
REVIEW
Evelyn L Jara, Natalia Muñoz-Durango, Carolina Llanos, Carlos Fardella, Pablo A González, Susan M Bueno, Alexis M Kalergis, Claudia A Riedel
Accumulating evidence suggests a close bidirectional communication and regulation between the neuroendocrine and immune systems. Thyroid hormones (THs) can exert responses in various immune cells, e.g., monocytes, macrophages, natural killer cells, and lymphocytes, affecting several inflammation-related processes (such as, chemotaxis, phagocytosis, reactive oxygen species generation, and cytokines production). The interactions between the endocrine and immune systems have been shown to contribute to pathophysiological conditions, including sepsis, inflammation, autoimmune diseases and viral infections...
February 16, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28212640/urinary-iodine-in-early-pregnancy-is-associated-with-subclinical-hypothyroidism-in-tianjin-china-an-observational-study
#7
Kunling Wang, Jie Zhang, Fengao Li, Wanqi Zhang, Hao Wang, Li Ding, Yaxin Liu, Laixiang Lin, Shuang Zhang, Mei Zhu
BACKGROUND: Subclinical hypothyroidism (SH) is associated with adverse obstetric outcomes and neurodevelopment disorders. Both iodine deficiency and excess are associated with SH; however, few data regarding iodine nutrition status of pregnant women with SH are available. This study aimed to clarify whether iodine deficiency or excess is associated with SH, especially, when test results for anti-thyroid autoantibodies are negative. METHODS: A total of 115 women with SH and 104 women with euthyroidism (EH) in early pregnancy in Tianjin, China were investigated, and their serum thyroid-stimulating hormone, free thyroxine, free triiodothyronine, anti-thyroid peroxidase antibody (TPOAb), anti-thyroid globulin antibody (TGAb), urinary iodine (UIC), and urinary creatinine (UCr) concentrations were measured...
February 17, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28203468/nonconvulsive-status-epilepticus-resembling-clinical-absence-with-atypical-eeg-pattern
#8
Channaiah Srikanth Mysore, Najib Murr, Rana Zabad, John Bertoni
Objective. We are reporting two cases: a patient with steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) and another patient with secondary progressive multiple sclerosis (SPMS), both presenting with altered mental status (AMS) and later diagnosed with nonconvulsive atypical absence status epilepticus (AS), with atypical EEG changes. Methods. A report of two cases. Results. A patient with history of SREAT and the other with SPMS had multiple admissions due to AMS. For both, EEG revealed the presence of a high voltage generalized sharply contoured theta activity...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28199771/thyroid-dysfunction-in-children-with-autism-spectrum-disorder-is-associated-with-folate-receptor-alpha-autoimmune-disorder
#9
Richard E Frye, Rebecca Wynne, Shannon Rose, John Slattery, Leanna Delhey, Marie Tippett, Stephen G Kahler, Sirish C Bennuri, Stepan Melnyk, Jeffrey M Sequeira, Edward Quadros
Folate receptor α (FRα) autoantibodies (FRAAs) are prevalent in Autism Spectrum Disorder (ASD). FRAAs disrupt folate transport across the blood-brain barrier by binding to the FRα. Thyroid dysfunction is frequently found in children with ASD. We measured blocking and binding FRAAs and thyroid stimulating hormone (TSH), free T4 (FT4), total T3 (TT3), reverse T3 (rT3), thyroid releasing hormone (TRH) and other metabolites in 87 children with ASD, 84 of whom also underwent behavior and cognition testing and in 42 of whom FRAAs, TSH and FT4 were measured at two time points...
February 15, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28195542/intraindividual-variation-of-microrna-expression-levels-in-plasma-and-peripheral-blood-mononuclear-cells-and-the-associations-of-these-levels-with-the-pathogenesis-of-autoimmune-thyroid-diseases
#10
Hiroshi Otsu, Mikio Watanabe, Naoya Inoue, Ryota Masutani, Yoshinori Iwatani
BACKGROUND: MicroRNAs (miRNAs) circulate in the blood and negatively regulate the expression of mRNAs. Some miRNAs are associated with the development of autoimmune thyroid diseases (AITD); however, there are few reports on the association between miRNA expression and the pathogenesis of AITD or the physiological variations of circulating miRNAs, which are important to examine as biomarkers. METHODS: We examined the circadian and day-to-day variations in the expression levels of 5 miRNAs (miR-125a, miR-146a, miR-155, let-7e and miR-106a) in plasma and peripheral blood mononuclear cells (PBMC)...
February 14, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28191014/extrahepatic-autoimmune-diseases-in-patients-with-autoimmune-liver-diseases-a-phenomenon-neglected-by-gastroenterologists
#11
REVIEW
Liping Guo, Lu Zhou, Na Zhang, Baoru Deng, Bangmao Wang
Autoimmune liver diseases (AILDs) often coexist with other extrahepatic autoimmune diseases (EHAIDs). The spectrum of EHAIDs in patients with AILDs is similar, whereas the incidence is different. Notably, autoimmune thyroid disease and Sjogren's syndrome are the most common EHAIDs. Associated extrahepatic diseases may predate the appearance of AILDs or coincide with their onset. More frequently, they may appear during the course and even occur years after the diagnosis of AILDs. Importantly, associated EHAIDs may influence the natural course and prognosis of AILDs...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28190705/risk-of-autoimmune-diseases-and-human-papilloma-virus-hpv-vaccines-six-years-of-case-referent-surveillance
#12
Lamiae Grimaldi-Bensouda, Michel Rossignol, Isabelle Koné-Paut, Alain Krivitzky, Christine Lebrun-Frenay, Johanna Clet, David Brassat, Caroline Papeix, Marc Nicolino, Pierre-Yves Benhamou, Olivier Fain, Nathalie Costedoat-Chalumeau, Marie-France Courcoux, Jean-François Viallard, Bertrand Godeau, Thomas Papo, Patrick Vermersch, Isabelle Bourgault-Villada, Gerard Breart, Lucien Abenhaim
BACKGROUND: Safety of HPV vaccines is still in question due to reports of autoimmune diseases (ADs) following HPV immunization. OBJECTIVES: To assess the risk of ADs associated with HPV vaccination of female adolescents/young adults in France. METHODS: Systematic prospective case-referent study conducted to assess the risks associated with real-life use of HPV vaccines. Cases were female 11-25 years old with incident ADs [central demyelination/multiple sclerosis (CD/MS), connective tissue disease (CTD), Guillain-Barré syndrome (GBS), type-1 diabetes (T1D), autoimmune thyroiditis (AT), and idiopathic thrombocytopenic purpura (ITP)]...
February 9, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28187375/a-comparative-study-of-nuclear-8-hydroxyguanosine-expression-in-autoimmune-thyroid-diseases-and-papillary-thyroid-carcinoma-and-its-relationship-with-p53-bcl-2-and-ki-67-cancer-related-proteins
#13
Malek Mseddi, Riadh Ben Mansour, Naourez Gouiia, Fatma Mnif, Rabï Bousselaa, Mohamed Abid, Tahia Boudaouara, Hamadi Attia, Saloua Lassoued
PURPOSE: To investigate whether the oxidative stress is involved in the evolution of Graves' disease (GD) and Hashimoto thyroiditis (HT) into Papillary Thyroid Carcinoma (PTC), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and cancer related proteins (Bcl-2, p53 and Ki-67) expressions were evaluated in these pathologies. PATIENTS AND METHODS: Immunohistochemical method was applied on 25 thyroid tissues. Allred score (AS) serving to evaluate the immunostaining is based on a scale from 0 to 8...
June 22, 2016: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28181228/thyrotropin-receptor-gene-expression-in-the-association-between-chronic-spontaneous-urticaria-and-hashimoto-s-thyroiditis
#14
Maria R C Silvares, Maria R P Fortes, Renata de A M L Nascimento, Carlos R Padovani, Hélio A Miot, Célia R Nogueira, Gláucia M F da S Mazeto
BACKGROUND: Chronic spontaneous urticaria (CSU) may be associated with autoimmune thyroid diseases, and the Autologous Serum Skin Test (ASST) is an autoreactivity marker. The thyrotropin (TSH) and TSH receptor (TSHR) could play a role in the pathogenesis of CSU. The aim of this study was to evaluate ASST positivity and TSHR gene expression in healthy skin and ASST wheals in euthyroid women with CSU, with (14 patients) and without (15 patients) Hashimoto's thyroiditis (HT). METHODS: ASST was performed and TSHR gene expression studied in wheals induced by ASST and in healthy skin...
February 8, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28176037/fibromyalgia-in-patients-with-thyroid-autoimmunity-prevalence-and-relationship-with-disease-activity
#15
Sema Haliloglu, Bilge Ekinci, Hulya Uzkeser, Hakan Sevimli, Ayse Carlioglu, Pinar Mazlum Macit
Fibromyalgia (FM) is a syndrome characterised by chronic musculoskeletal pain, tenderness and other somatic symptoms. The prevalence of FM is approximately 2-7% in the general global population and is 30-40% in the population of Hashimoto thyroiditis (HT) with a structural pathology. In 2010, new classification criteria for FM were proposed, as an alternative to the American College of Rheumatology (ACR) 1990 criteria. The objectives of the present study were to identify the prevalence of FM in the HT population and evaluate the associated features by using the new diagnostic criteria...
February 7, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28171686/the-relationship-between-procalcitonin-and-thyroid-autoantibodies-in-patients-with-autoimmune-thyroiditis
#16
Ali Oncul, Ihsan Ates, Mehmet Fettah Arikan, Nisbet Yilmaz, Canan Topcuoglu, Fatma Meric Yilmaz, Mustafa Altay
BACKGROUND: The aim of this study is to investigate the serum levels of procalcitonin and its association with autoantibodies in patients with euthyroid Hashimoto's thyroiditis. METHODS: A total of 80 participants were included in the study; 40 of which were newly diagnosed with Hashimoto's thyroiditis, aged over 18, and 40 of which were healthy volunteers. The serum levels of procalcitonin were measured by enzyme-linked immunosorbent assay kit. Thyroid function tests were analyzed in hormone laboratory with Electro-chemiluminescence immunoassay...
February 7, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28167127/-with-a-little-help-from-my-friends-the-role-of-microbiota-in-thyroid-hormone-metabolism-and-enterohepatic-recycling
#17
Camilla Virili, Marco Centanni
The gut microbiota is composed of over 1200 species of anaerobes and aerobes bacteria along with bacteriophages, viruses and fungal species. Increasing evidence indicates that the intestinal microbiota, beside digestive equilibrium, is also crucial for immunologic, hormonal and metabolic homeostasis. The intestinal microbiota interacts with distant organs by signals which may be part of the bacteria themselves or their metabolites. Dysbiosis has been observed in inflammatory or autoimmune disorders such as multiple sclerosis or type 1 diabetes as well as in obesity and type 2 diabetes...
February 4, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28165551/thyroid-disorders-in-polycystic-ovary-syndrome
#18
K Kowalczyk, G Franik, D Kowalczyk, D Pluta, Ł Blukacz, P Madej
OBJECTIVE: Thyroid disorders, especially Hashimoto's thyroiditis (HT), are observed significantly more often in patients with polycystic ovary syndrome (PCOS) than in the general population - approximately 27% and 8%, respectively. This is extremely important in young women, because both disorders are connected with fertility problems. As HT and PCOS occur together, fertility problems may become a serious clinical issue in these patients. MATERIALS AND METHODS: A systematic literature review in PubMed of PCOS- and HT-related articles in English, published until December 2015 was conducted...
January 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28164629/a-controversial-new-approach-to-address-hematological-parameters-in-hashimoto-s-thyroiditis
#19
Dilek Arpaci, Gonul Gurol, Hasan Ergenc, Hayrullah Yazar, Aysel G Tocoglu, Ihsan H Ciftci, Ali Tamer
BACKGROUND: Hashimoto's thyroiditis (HT) is a common autoimmune disorder. Genetic, environmental, and immunological factors all play a role in the pathogenesis of HT, but the effects of lymphocytes and platelets on the pathophysiology of HT are still unknown. In this study, we evaluated the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in HT groups and HT subgroups with low cardiovascular risks. METHODS: This study included 92 patients with HT and 38 control subjects...
July 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164472/the-il15-96522-a-t-functional-polymorphism-is-related-to-the-differentiation-of-th17-cells-and-the-severity-of-hashimoto-s-disease
#20
Y Arakawa, M Watanabe, K Takemura, N Inoue, Y Hidaka, Y Iwatani
To clarify the association between the genetic producibility of IL-15, a pro-inflammatory cytokine, and the pathogenesis of autoimmune thyroid diseases (AITDs), we genotyped +96522 A>T and +82889 A>G polymorphisms in the IL15 gene using 127 patients with Hashimoto's disease (HD), including 55 patients with severe HD and 48 patients with mild HD; 130 patients with Graves' disease (GD), including 52 patients with intractable GD and 44 patients with GD in remission; and 79 healthy volunteers. Both the IL15 +96522 A allele and AA genotype were more frequent in patients with severe HD than in those with mild HD...
February 5, 2017: International Journal of Immunogenetics
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