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Thyroid autoimmunity

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https://www.readbyqxmd.com/read/28810821/idiopathic-low-ovarian-reserve-is-associated-with-more-frequent-positive-thyroid-peroxidase-antibody
#1
Chien-Wen Chen, Ya-Li Huang, Rui Lan Huang, Chii-Ruey Tzeng, Chi-Huang Chen
BACKGROUND: While screening on thyroid peroxidase antibody (TPO-Ab) has been recommended in women with primary ovarian insufficiency, the relationship between thyroid autoimmunity (TAI) and ovarian reserve remains undetermined. Because the TAI prevalence was reported to be different between races, we aimed to investigate the TAI prevalence in Chinese women with different ovarian reserve. METHODS: This is a cross-sectional study conducted in a university infertility clinic between October 2013 and March 2016...
August 16, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28805450/commentary-health-concerns-of-brazil-nut-consumption
#2
Elias E Mazokopakis, Michael I Liontiris
Brazil nuts are the fruit of the enormous tropical tree Bertholletia excelsa that are produced in and exported from the territory of the Amazon. As a natural rich source of selenium (Se), the consumption of Brazil nuts is often suggested as therapeutic among patients with autoimmune thyroid diseases. In this review, the current knowledge regarding the main health concerns of Brazil nut consumption, such as Se toxicity, Se-induced type 2 diabetes mellitus, weight gain, radioactivity, aflatoxins, and allergic reactions, is presented and discussed...
August 14, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28805160/clinical-implications-of-immunoglobulin-g4-to-graves-ophthalmopathy
#3
Sung Hoon Yu, Jun Goo Kang, Chul Sik Kim, Sung-Hee Ihm, Moon Gi Choi, Hyung Joon Yoo, Seong Jin Lee
BACKGROUND: This study aimed to explore relation of immunoglobulin G4 (IgG4) to clinical and laboratory characteristics of patients newly diagnosed with Graves' disease (GD) without or with Graves' ophthalmopathy (GO), and to analyze association of IgG4 with development and grade of GO in GD patients. METHODS: Sixty-four GD patients and 64 sex- and age-matched euthyroid subjects were enrolled. Serum levels of thyroid hormones, thyroid autoantibodies, immunoglobulin G (IgG) and IgG4 were measured, and ophthalmological and ultrasonographical evaluation was performed...
August 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28804863/personalised-immunomodulating-treatments-for-graves-disease-fact-or-fiction
#4
Tristan Mirko Struja, Alexander Kutz, Stefan Fischli, Christian Meier, Beat Müller, Philipp Schütz
Although Graves' disease has been recognised for more than 100 years, its physiopathological mechanisms are incompletely understood. Treatment strategies today mainly focus on suppression of thyroid hormone production by use of antithyroid drugs or radio-iodine, but neglect the underlying immunological mechanisms. Although Graves' disease is often seen as a prototype for an autoimmune mechanism, it is more likely to be a heterogeneous syndrome showing characteristics of both autoimmunity and immunodeficiency...
August 14, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28803408/iodine-rich-herbs-and-potassium-iodate-have-different-effects-on-the-oxidative-stress-and-differentiation-of-th17-cells-in-iodine-deficient-nod-h-2-h4-mice
#5
Cheng-Han Gao, Jin-Qiao Qu, Xi-Yu Zhou, Tian-Shu Gao
Iodine-rich herbs such as seaweed, kelp, and sea tangle were widely used to treat various types of goiter with good effect and without any adverse side effects in China. When compared with potassium iodate (PI), iodine-rich herbs had a positive effect on the recovery of goiter resulting from iodine deficiency without any obvious harmful effects. In NOD.H-2(h4) mice, an autoimmune thyroiditis-prone model, iodine excess can increase infiltration of lymphocytes and structural damage of the thyroid follicles, hence resulting in thyroiditis...
August 12, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28800677/levothyroxine-enhances-glucose-clearance-and-blunts-the-onset-of-experimental-type-1-diabetes-mellitus-in-mice
#6
Livia López-Noriega, Nadia Cobo-Vuilleumier, Álvaro Jesús Narbona-Pérez, Juan Luis Araujo-Garrido, Petra Isabel Lorenzo, José Manuel Mellado-Gil, José Carlos Moreno, Benoit R Gauthier, Alejandro Martín-Montalvo
BACKGROUND AND PURPOSE: Thyroid hormones induce several changes in whole body metabolism that are known to improve metabolic homeostasis. However, adverse side effects have prevented its use in the clinic. In view of the promising effects of thyroid hormones, we investigated the effects of levothyroxine supplementation in glucose. EXPERIMENTAL APPROACH: C57BL/6 mice were treated with levothyroxine from birth to 24 weeks of age, when mice were euthanized. The effects of levothyroxine supplementation on metabolic health were determined...
August 11, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28794611/single-nucleotide-polymorphism-1623-a-g-rs180195-in-the-promoter-of-the-thyroglobulin-gene-is-associated-with-autoimmune-thyroid-disease-but-not-with-thyroid-ophthalmopathy
#7
Hooshang Lahooti, Senarath Edirimanne, John P Walsh, Leigh Delbridge, Emily J Hibbert, Jack R Wall
BACKGROUND: Our studies over recent years have focused on some new ideas concerning the pathogenesis for the orbital reaction that characterizes Graves' ophthalmopathy namely, that there are antigens expressed by thyroid tissue and orbital tissue where they are targeted by autoantibodies and/or sensitized T cells, leading to orbital inflammation. While this has been well studied for the thyroid stimulating hormone-receptor, the possible role of another major thyroid antigen, Thyroglobulin (TG), has been largely ignored...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28794075/non-surgical-treatment-for-eyelid-retraction-in-thyroid-eye-disease-ted
#8
REVIEW
Ana Beatriz Diniz Grisolia, Ricardo Christopher Couso, Suzana Matayoshi, Raymond S Douglas, César Augusto Briceño
Thyroid eye disease (TED) is an autoimmune condition with an unpredictable course that may lead to permanent facial disfigurement. Eyelid retraction is one of the most common findings, and frequently demands attention due to ocular exposure and impaired cosmesis. Surgical treatment remains the most effective option, but there is a role for temporary corrections during the active phase of the disease, as well as in patients who are poor surgical candidates. The aim of this review is to describe the non-surgical modalities currently available for treatment of eyelid malposition in TED...
August 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28791826/trends-in-the-prevalence-of-autoimmune-thyroiditis-in-the-leading-private-health-care-provider-in-poland
#9
Paweł Jóźków, Felicja Lwow, Małgorzata Słowińska-Lisowska, Marek Mędraś
BACKGROUND: Autoimmune thyroiditis (AT) is one of the most common endocrine disorders affecting a significant percent of the population, especially women. It may have serious and long-lasting consequences. The etiology of AT is multifactorial and it arises from an interplas between environmental and genetic factors. Tendencies in AT prevalence and incidence are unclear. In Poland there are no national registers covering the data on AT prevalence. OBJECTIVES: The aim of the investigation was to assess changes in diagnosing AT in the largest chain of outpatient medical centers in Poland...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28770897/typical-graves-ophthalmopathy-in-primary-hypothyroidism
#10
Zareen Kiran, Owais Rashid, Najmul Islam
Graves ophthalmopathy (GO) usually occurs in a close temporal relationship with hyperthyroidism. It is rare in patients with normal thyroid function (euthyroid GO) and in patients with hypothyroid forms of thyroid autoimmune diseases (hypothyroid GO). We report a 52-years old man presenting in our endocrine clinic with diagnosed primary hypothyroidism 3 months back during evaluation for glaucoma. He was later referred by an ophthalmologist to exclude Grave's eye disease, where he had presented with chief complaints of bilateral prominent eyes...
July 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28768936/comparison-of-thyroglobulin-and-thyroid-peroxidase-antibodies-measured-by-five-different-kits-in-autoimmune-thyroid-diseases
#11
Eijun Nishihara, Nobuyuki Amino, Takumi Kudo, Mitsuru Ito, Shuji Fukata, Mitsushige Nishikawa, Hirotoshi Nakamura, Akira Miyauchi
It is generally believed that the detection of thyroid peroxidase antibodies (TPOAb) is superior to that of thyroglobulin antibodies (TgAb) for the diagnosis of Hashimoto's thyroiditis. However, limited data are available on the comparison of TgAb and TPOAb prevalence as a diagnostic measurement for Hashimoto's thyroiditis using sensitive immunoassays. We herein used five different current immunoassay kits (A-E) to compare the prevalence of TgAb and TPOAb in Hashimoto's thyroiditis (n = 70), Graves' disease (n = 70), painless thyroiditis (n = 50), and healthy control subjects (n = 100)...
August 2, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28761890/microscopic-colitis-after-fecal-microbiota-transplant
#12
Matthew J Fasullo, Yasir Al-Azzawi, Jeffrey Abergel
Microscopic colitis (MC) is an inflammatory condition of the large bowel that is associated with chronic, nonbloody diarrhea. Colonoscopy usually demonstrates normal mucosa, while tissue biopsy reveals intraepithelial lymphocytes or a subepithelial collagen band. Although no specific antibody has been discovered, MC is associated with several autoimmune disorders such as celiac disease, Hashimoto's thyroiditis, and rheumatoid arthritis. There are only a small number of case reports documenting possible hereditary MC cases, but up to 12% of patients with MC have a family history of inflammatory bowel disease...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28761351/alemtuzumab-a-review-of-efficacy-and-risks-in-the-treatment-of-relapsing-remitting-multiple-sclerosis
#13
REVIEW
Cristina Guarnera, Placido Bramanti, Emanuela Mazzon
Alemtuzumab is a selective humanized monoclonal antibody directed against the CD52 antigen, and has been found to be a powerful treatment for relapsing remitting multiple sclerosis. Alemtuzumab demonstrated high efficacy in several clinical studies. The risk of relapse and sustained accumulation of disability showed significant reduction in the Phase II CAMMS223 and the Phase III clinical trials CARE MS I and CARE MS II. The data presented at the 32nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis confirmed these results...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28756232/tim3-galectin-9-alleviates-the-inflammation-of-tao-patients-via-suppressing-akt-nf-kb-signaling-pathway
#14
Lihua Luo, Dongmei Li, Kang Wang, Shuang Li, Jigang Yang, Chunlin Li, Wei Feng, Hong Guo
Thyroid-associated ophthalmopathy (TAO) is an autoimmune disease. Studies showed that T helper 1 (Th1), Th2, and Th17 cells play important roles in the pathology of TAO. Tim-3 and its only known ligand Galectin-9 (Gal-9) is related to the suppression of Th1 and Th17 cytokine secretion. This study aims to investigate the role of Tim3/Gal-9 in the inflammatory response of TAO. In this study, the levels of Tim3, Gal-9, and cytokines of Th1 (TNF-α and IFN-γ), Th2 (IL-4), and Th17 (IL-17) cells were analyzed in the blood samples of TAO patients and healthy controls as well as in orbital fibroblasts...
July 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28753406/association-of-established-thyroid-stimulating-hormone-and-free-thyroxine-genetic-variants-with-hashimoto-s-thyroiditis
#15
Luka Brčić, Sanda Gračan, Ana Barić, Ivana Gunjača, Vesela Torlak Lovrić, Ivana Kolčić, Tatijana Zemunik, Ozren Polašek, Maja Barbalić, Ante Punda, Vesna Boraska Perica
Hashimoto's thyroiditis (HT), the most frequent autoimmune thyroid disease (AITD), is characterized by chronic inflammation of the thyroid gland that usually results in hypothyroidism. Thyroid-stimulating hormone (TSH) and free thyroxine (FT4) levels are used as clinical determinants of thyroid function. The main aim of this study was to explore the association of established TSH and FT4 genetic variants with HT. We performed a case-control analysis using 23 genetic markers in 200 HT patients and 304 controls...
August 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28751878/autoimmune-thyroiditis-and-myasthenia-gravis
#16
REVIEW
Angela Lopomo, Sonia Berrih-Aknin
Autoimmune diseases (AIDs) are the result of specific immune responses directed against structures of the self. In normal conditions, the molecules recognized as "self" are tolerated by immune system, but when the self-tolerance is lost, the immune system could react against molecules from the body, causing the loss of self-tolerance, and subsequently the onset of AID that differs for organ target and etiology. Autoimmune thyroid disease (ATD) is caused by the development of autoimmunity against thyroid antigens and comprises Hashimoto's thyroiditis and Graves disease...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28751877/autoimmune-abnormalities-of-postpartum-thyroid-diseases
#17
REVIEW
Flavia Di Bari, Roberta Granese, Maria Le Donne, Roberto Vita, Salvatore Benvenga
The year following parturition is a critical time for the de novo appearance or exacerbation of autoimmune diseases, including autoimmune thyroid disease. The vast majority of postpartum thyroid disease consists of postpartum thyroiditis (PPT) and the minority by Graves' disease and non-autoimmune thyroiditis. PPT has a worldwide prevalence ranging from 1 to 22% and averaging 5% based on a review published in 2012. Several factors confer risk for the development of PPT. Typically, the clinical course of PPT is characterized by three phases: thyrotoxic, hypothyroid, and euthyroid phase...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28747386/the-association-of-autoimmune-thyroid-disease-aitd-with-psoriatic-disease-a-prospective-cohort-study-systematic-review-and-meta-analysis
#18
Samer R Khan, Arjola Bano, Marlies Wakkee, Tim Korevaar, Oscar Franco, Tamar Nijsten, Robin P Peeters, L Chaker
Objective Autoimmune thyroid disease (AITD) and psoriatic disease share auto-immunological components. Few studies have investigated the link between both, yielding inconclusive results. Design We assessed the association of AITD with psoriatic disease in a prospective cohort study, and performed a systematic review and meta-analysis. Methods 8,214 participants of the Rotterdam Study (RS) with thyroid peroxidase antibodies (TPO-Abs), thyroid stimulating hormone (TSH) and/or free thyroxine (FT4) measurements and information on psoriatic disease were included...
July 26, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28742402/association-of-il-10-regulating-micrornas-in-peripheral-blood-mononuclear-cells-with-the-pathogenesis-of-autoimmune-thyroid-disease
#19
Yukina Takuse, Mikio Watanabe, Naoya Inoue, Ritsuko Ozaki, Hiroshi Ohtsu, Minori Saeki, Yuka Katsumata, Yoh Hidaka, Yoshinori Iwatani
Interleukin (IL)-10 is known to suppress inflammation in autoimmune diseases. IL-10 can be regulated by miRNAs. To elucidate the involvement of miRNAs that regulate IL-10 expression with the pathogenesis of autoimmune thyroid disease (AITD), we examined the expression levels of hsa-miR-27a-3p, hsa-miR-98-5p, hsa-miR-106a-5p, and hsa-miR-223-3p in peripheral blood mononuclear cells (PBMCs) from 43 patients with Graves' disease (GD), 38 patients with Hashimoto's disease (HD), and 21 healthy volunteers. We evaluated the association between the expression levels of four miRNAs and intracellular expression of IL-10 in PBMCs from 11 healthy volunteers...
August 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28742400/role-of-different-cd40-polymorphisms-in-graves-disease-and-hashimoto-s-thyroiditis
#20
Dongguo Wang, Jiayu Chen, Huanyuan Zhang, Fangfang Zhang, Linjun Yang, Yonghua Mou
Genome-wide association studies have led to the discovery of several susceptibility genes related to autoimmune thyroid diseases (AITDs). However, controversial results have been reported regarding the role of single-nucleotide polymorphism (SNP) of CD40 in the disease susceptibility. The objective of this study was to identify the relationship of the polymorphisms of three sites of CD40 with the susceptibility to AITD in the Chinese population. We genotyped three polymorphisms of CD40: C/T -1 SNP, 58038T site of the third exon and C64610G site of the ninth exon in 196 GD cases, 121 HT cases and 122 control subjects...
August 2017: Immunological Investigations
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