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https://www.readbyqxmd.com/read/29679626/microrna-expression-profile-in-plasma-from-type-1-diabetic-patients-case-control-study-and-bioinformatic-analysis
#1
Taís S Assmann, Mariana Recamonde-Mendoza, Márcia Puñales, Balduíno Tschiedel, Luís H Canani, Daisy Crispim
AIMS: To investigate a miRNA expression profile in plasma of type 1 diabetes (T1DM) patients and control subjects and analyze the putative pathways involved. METHODS: Expressions of 48 miRNAs were analyzed in plasma of 33 T1DM patients and 26 age-and-gender-matched controls using Stem-loop RT-PreAmp PCR and TaqMan Low Density Arrays (Thermo Fisher Scientific). Five dysregulated miRNAs were then chosen for validation in an independent sample of 27 T1DM patients and 14 controls, using RT-qPCR...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679487/allergen-specific-immunotherapy-induces-regulatory-t-cells-in-an-atopic-dermatitis-mouse-model
#2
Jung U Shin, Seo Hyeong Kim, Ji Yeon Noh, Ji Hye Kim, Kim Hye Ran, Kyoung Yong Jeong, Kyung Hee Park, Jungsoo Lee, Howard Chu, Jae-Hyun Lee, Tai-Soon Yong, Jung-Won Park, Kwang Hoon Lee
BACKGROUND: Several studies have demonstrated that allergen-specific immunotherapy (SIT) can be an effective treatment for atopic dermatitis (AD). However, there is no relevant mouse model to investigate the mechanism and validate the novel modality of SIT in AD. METHODS: NC/Nga mice with induced AD-like skin lesions received a subcutaneous injection of SIT (an extract of the house dust mite Dermatophagoides farinae [DfE]) or placebo for 5 weeks). Clinical and histological improvements of AD-like skin lesions were examined...
April 21, 2018: Allergy
https://www.readbyqxmd.com/read/29679109/parallel-versus-orthogonal-plate-osteosynthesis-of-adult-distal-humerus-fractures-a-meta-analysis-of-biomechanical-studies
#3
Chien-An Shih, Wei-Ren Su, Wei-Chin Lin, Tai-Wei Tai
PURPOSE: There are two widely used distal humerus fracture (DHF) fixation methods with either orthogonal or parallel double-plate osteosynthesis. However, biomechanical studies have shown inconsistent results on which technique is more effective. We performed a meta-analysis to compare these two fixation methods for adult DHF fixation. METHODS: We searched the literature for entries discussing the biomechanical testing of orthogonal and parallel fixation techniques for DHFs...
April 20, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29679033/innovatively-therapeutic-strategy-on-lung-cancer-by-daily-drinking-antioxidative-plasmon-induced-activated-water
#4
Chien-Kai Wang, Hsiao-Chien Chen, Sheng-Uei Fang, Chia-Wen Ho, Cheng-Jeng Tai, Chih-Ping Yang, Yu-Chuan Liu
Many human diseases are inflammation-related, such as cancer and those associated with aging. Previous studies demonstrated that plasmon-induced activated (PIA) water with electron-doping character, created from hot electron transfer via decay of excited Au nanoparticles (NPs) under resonant illumination, owns reduced hydrogen-bonded networks and physchemically antioxidative properties. In this study, it is demonstrated PIA water dramatically induced a major antioxidative Nrf2 gene in human gingival fibroblasts which further confirms its cellular antioxidative and anti-inflammatory properties...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678829/draft-genome-sequence-of-camellia-sinensis-var-sinensis-provides-insights-into-the-evolution-of-the-tea-genome-and-tea-quality
#5
Chaoling Wei, Hua Yang, Songbo Wang, Jian Zhao, Chun Liu, Liping Gao, Enhua Xia, Ying Lu, Yuling Tai, Guangbiao She, Jun Sun, Haisheng Cao, Wei Tong, Qiang Gao, Yeyun Li, Weiwei Deng, Xiaolan Jiang, Wenzhao Wang, Qi Chen, Shihua Zhang, Haijing Li, Junlan Wu, Ping Wang, Penghui Li, Chengying Shi, Fengya Zheng, Jianbo Jian, Bei Huang, Dai Shan, Mingming Shi, Congbing Fang, Yi Yue, Fangdong Li, Daxiang Li, Shu Wei, Bin Han, Changjun Jiang, Ye Yin, Tao Xia, Zhengzhu Zhang, Jeffrey L Bennetzen, Shancen Zhao, Xiaochun Wan
Tea, one of the world's most important beverage crops, provides numerous secondary metabolites that account for its rich taste and health benefits. Here we present a high-quality sequence of the genome of tea, Camellia sinensis var. sinensis (CSS), using both Illumina and PacBio sequencing technologies. At least 64% of the 3.1-Gb genome assembly consists of repetitive sequences, and the rest yields 33,932 high-confidence predictions of encoded proteins. Divergence between two major lineages, CSS and Camellia sinensis var...
April 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29678567/germ-cell-specific-apoptosis-by-extracellular-clusterin-in-cryptorchid-dog-testes
#6
Hyunjhung Jhun, Hyun-Jung Park, Ran Lee, Hyuk Song, Tai-Young Hur, Seunghoon Lee, Jin-Ki Park, Won-Young Lee
Mammalian testes are maintained at a relatively lesser temperature than the abdominal region so that normal spermatogenesis can occur. Germ cell apoptosis has resulted in heat-damaged testes that occurs as a result of cryptorchidism, but the mechanism is not yet fully understood. To elucidate the cause of germ-cell death by cryptorchidism, cryptorchidism was surgically induced in dog testes and histological and molecular analyses were performed. Histological data indicated that the seminiferous tubules of cryptorchid testes and epididymis contained fewer germ cells...
April 13, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29678206/biliverdin-reductase-a-attenuated-gmh-induced-inflammatory-response-in-the-spleen-by-inhibiting-toll-like-receptor-4-through-enos-no-pathway
#7
Yiting Zhang, Yan Ding, Tai Lu, Yixin Zhang, Ningbo Xu, Devin W McBride, Jiping Tang, John H Zhang
BACKGROUND: Germinal matrix hemorrhage (GMH) is a common neurologic event with high morbidity and mortality in preterm infants. Spleen has been reported to play a critical role in inflammatory responses by regulating peripheral immune cells which contributes to secondary brain injury. METHODS: The current study investigated the mechanistic role of biliverdin reductase-A (BLVRA) in the splenic response and brain damage in neonates following a collagenase GMH model...
April 20, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29677526/anti-inflammatory-effects-of-4-o-methyl-benzenesulfonyl-benzoxazolone-mbb-in-vivo-and-in-vitro-as-a-novel-nsaids-lead-compound
#8
Li Tang, Jie-Ran Luo, Dai-Tian Li, Rui Ge, Yun-Long Ma, Fei Xu, Tai-Gang Liang, Shu-Rong Ban, Qing-Shan Li
BACKGROUND: Great attention has been paid to the development of novel anti-inflammatory drugs to overcome the adverse reactions of traditional drugs. Recently, a new compound 4-o-methyl-benzenesulfonyl benzoxazolone (MBB) we have prepared attracted our attention for its promising anti-inflammatory activity and low toxicity. The present study aimed to further investigate the anti-inflammatory effects of MBB both in vivo and in vitro in order to determine its potential as a novel NSAIDs lead compound...
December 15, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29675438/fgfrl1-promotes-ovarian-cancer-progression-by-crosstalk-with-hedgehog-signaling
#9
Haiyan Tai, Zhiyong Wu, Su'an Sun, Zhigang Zhang, Congjian Xu
Fibroblast growth factor receptor-like-1 (FGFRL1) has been identified as the fifth fibroblast growth factor receptor. So far, little is known about its biological functions, particularly in cancer development. Here, for the first time, we demonstrated the roles of FGFRL1 in ovarian carcinoma (OC). An array and existing databases were used to investigate the expression profile of FGFRL1 and the relationship between FGFRL1 expression and clinicopathological parameters. FGFRL1 was significantly upregulated in OC patients, and high FGFRL1 expression was correlated with poor prognosis...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29675236/a-simple-multi-responsive-system-based-on-aldehyde-functionalized-amino-boranes
#10
Yong-Gang Shi, Jun-Wei Wang, Haijun Li, Guo-Fei Hu, Xue Li, Soren K Mellerup, Nan Wang, Tai Peng, Suning Wang
A simple aldehyde functionalized amino-triarylborane donor-acceptor system ( BO-1 ) was found to display distinct responses toward multiple external stimuli including solvent, temperature and pressure, with emission colours changing from blue to red. The operating mechanism most likely involves reversible switching between closed and open structures based on an intramolecular B ← O bond. Imbedded donor-acceptor charge transfer transitions played a key role in the multi-coloured fluorescent response of this new boron system to external stimuli...
February 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29674172/generation-of-induced-pluripotent-stem-cells-from-a-patient-with-x-linked-juvenile-retinoschisis
#11
Chi-Hsien Peng, Kang-Chieh Huang, Huai-En Lu, Shih-Han Syu, Aliaksandr A Yarmishyn, Jyh-Feng Lu, Waradee Buddhakosai, Tai-Chi Lin, Chih-Chien Hsu, De-Kuang Hwang, Chia-Ning Shen, Shih-Jen Chen, Shih-Hwa Chiou
X-linked juvenile retinoschisis (XLRS) is a hereditary retinal dystrophy manifested as splitting of anatomical layers of retina. In this report, we generated a patient-specific induced pluripotent stem cell (iPSC) line, TVGH-iPSC-013-05, from the peripheral blood mononuclear cells of a male patient with XLRS by using the Sendai-virus delivery system. We believe that XLRS patient-specific iPSCs provide a powerful in vitro model for evaluating the pathological phenotypes of the disease.
April 11, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29673030/dengue-fever-and-aedes-aegypti-in-indigenous-brazilians-seroprevalence-risk-factors-knowledge-and-practices
#12
Luciano Pamplona de Góes Cavalcanti, Rafael Henrique Machado Sacramento, Fernanda Montenegro de Carvalho Araújo, Danielle Malta Lima, Carlos Carlos Henrique Alencar, Victor Emanuel Pessoa Martins, Lucas Venâncio Araújo, Tais Castelo de Oliveira
OBJECTIVE: Dengue remains an important public health problem in Brazil. We estimated the associated factors of dengue seroprevalence among native Indians of the Tremembé ethnic and their knowledge about the aspects related to the presence of mosquitoes of the genus Aedes. METHODS: An analytical cross-sectional study and a prospective environmental study to monitor the trapping of mosquito eggs monthly were performed. The serological portion of the study involved indigenous people living in the village of Tapera in northeastern Brazil...
April 19, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29672920/targeting-hsp60-by-subcutaneous-injections-of-jetpei-hsp60-shrna-destabilizes-cytoplasmic-survivin-and-inhibits-hepatocellular-carcinoma-growth
#13
Ya-Hui Huang, Kwang-Huei Lin, Jao-Song Yu, Ting-Jung Wu, Wei-Chen Lee, Chuck C-K Chao, Tai-Long Pan, Chau-Ting Yeh
Heat shock protein 60 (HSP60) overexpresses in various types of cancer, but its expression levels and functions in hepatocellular carcinoma (HCC) are still in dispute. We aim to clarify this issue and examine whether HSP60 could be a therapeutic target for HCC. We found drastically enhanced cell apoptosis and suppressed cell proliferation in two HCC cell lines with HSP60-silencing, and also indicated survivin is involved in this regulatory process in vitro and in vivo. However, HSP60-silencing in normal human hepatocytes only resulted in a minimal reduction of cell proliferation but without effects on cell apoptosis...
April 19, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29671497/osteoarthritis-rapid-evidence-review
#14
Mark H Ebell
Osteoarthritis (OA) should be suspected in patients with pain in the fingers, shoulders, hips, knees, or ankles, especially if they are older than 40 years. Patients older than 50 years who have joint pain, minimal morning stiffness, and functional impairment likely have OA. Radiography can confirm the diagnosis and may be helpful before surgical referral, but findings generally do not correlate well with symptoms. Exercise, physical therapy, knee taping, and tai chi are beneficial for knee OA. Medical therapy provides modest benefits in pain reduction and functional improvement; however, nonsteroidal anti-inflammatory drugs, tramadol, and other opioids have significant potential harms...
April 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29671049/parent-offspring-cohabitation-after-weaning-inhibits-partner-preference-and-alters-central-oxytocin-and-dopamine-systems-in-adult-mandarin-vole
#15
Ruiyong Wu, Zhenzhen Song, Fadao Tai
In some mammals, offspring may live with their parents for a very long time after weaning, but little is known about the effect of post-weaning parent-offspring cohabitation on the behavioral and neurobiological development of offspring. Here, we explored the effect of this experience on partner preference in adult mandarin vole (Microtus mandarinus). Levels of central oxytocin (OT), tyrosine hydroxylase (TH), as well as OT receptor (OTR), dopamine D1-type and D2-type receptors (D1R and D2R) mRNA expression in the nucleus accumbens (NAcc) and medial amygdala (MeA) were also measured...
April 18, 2018: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/29670854/deep-inspiration-breath-hold-techniques-and-advantages-for-cardiac-sparing-during-breast-cancer-irradiation
#16
REVIEW
Carmen Bergom, Adam Currey, Nina Desai, An Tai, Jonathan B Strauss
Historically, heart dose from left-sided breast radiotherapy has been associated with a risk of cardiac injury. Data suggests that there is not a threshold for the deleterious effects from radiation on the heart. Over the past several years, advances in radiation delivery techniques have reduced cardiac morbidity due to treatment. Deep inspiration breath hold (DIBH) is a technique that takes advantage of a more favorable position of the heart during inspiration to minimize heart doses over a course of radiation therapy...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29670476/the-effect-of-tai-chi-exercise-on-the-risk-and-fear-of-falling-in-older-adults-a-randomized-clinical-trial
#17
Hamed Mortazavi, Mahbubeh Tabatabaeichehr, Ali Golestani, Mohammad Reza Armat, Mohammad Reza Yousefi
Background: Falling and fear of falling are among the most common problems of the elderly, which can cause illness, isolation, dependency and reduced quality of life in elderly. Exercise is recommended to prevent falling injuries in the elderly. Aim: This study aimed to examine the effect of Tai Chi exercise on the risk and fear of falling in older adults. Materials and Methods: In this randomized clinical trial, a total of 60 male and female elderly were randomly divided into two groups: Tai Chi exercise and control (daily activities) groups...
March 2018: Materia Socio-medica
https://www.readbyqxmd.com/read/29670025/predicting-effects-of-psychological-inflexibility-experiential-avoidance-and-stress-coping-strategies-for-internet-addiction-significant-depression-and-suicidality-in-college-students-a-prospective-study
#18
Wei-Po Chou, Cheng-Fang Yen, Tai-Ling Liu
The aims of this study were to evaluate the predicting effects of psychological inflexibility/experiential avoidance (PI/EA) and stress coping strategies for Internet addiction, significant depression and suicidality among college students during the follow-up period of one year. A total of 500 college students participated in this study. The level of PI/EA and stress coping strategies were evaluated initially. One year later, 324 participants were invited to complete the Chen Internet Addiction Scale, Beck Depression Inventory-II and the questionnaire for suicidality to evaluate depression symptoms and internet addiction and suicidality...
April 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29669074/prostaglandin-f2%C3%AE-7-d-prior-to-initiation-of-the-7-d-co-synch-cidr-protocol-failed-to-enhance-estrus-response-and-pregnancy-rates-in-beef-heifers
#19
Nicola Oosthuizen, Luara B Canal, Pedro L P Fontes, Carla D Sanford, Nicolas DiLorenzo, Carl R Dahlen, George E Seidel, G Cliff Lamb
To determine the effects of administration of 25 mg of PGF2α 7 d prior to the initiation of the 7-d CO-Synch + controlled internal drug release (CIDR) fixed-time AI (TAI) protocol, 985 Bos taurus beef heifers were enrolled in a completely randomized design at 9 locations from April to July of 2016. Within location, all heifers were randomly assigned to 1 of 2 treatments: 1) CONTROL (n = 496); 100 µg injection of GnRH and a CIDR insert for 7 d [day 7], administration of 25 mg of PGF2α at CIDR removal [day 0], followed by a second injection of GnRH and TAI 54 ± 2 h later; or 2) PRESYNCH (n = 489); same as CONTROL but heifers received an additional injection of 25 mg of PGF2α 7 d prior [day 14] to CIDR insertion...
April 14, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29667766/role-of-clinical-trials-in-survival-progress-of-american-adolescents-and-young-adults-with-cancer-and-lack-thereof
#20
Archie Bleyer, Eric Tai, Stuart Siegel
In the United States, adolescent and young adult (AYA) patients with cancer have the lowest clinical trial participation rate of all age groups and slower progress in survival improvement than younger patients. Ominously, AYA clinical trial participation has been steadily decreasing since 2010, except in 15-19 year olds and AYAs with acute lymphoblastic leukemia. In order to reverse the accrual trend, multiple changes are necessary, including convincing community oncologists to pursue clinical trials on behalf of their AYA patients and to have the new National Community Oncology Research Program and National Clinical Trials Network lead a coordinated effort to increase accrual...
April 18, 2018: Pediatric Blood & Cancer
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