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https://www.readbyqxmd.com/read/28351029/cytopathological-changes-induced-by-the-crack-use-in-oral-mucosa
#1
Milena Binhame Albini, Ingra Taís Malacarne, Thiago Beltrami Dias Batista, Antônio Adilson Soares de Lima, Maria Angela Naval Machado, Aline Cristina Batista Rodrigues Johann, Edvaldo Antonio Ribeiro Rosa, Luciana Reis Azevedo-Alanis
AIMS: To evaluate cytological alterations, inflammation, and microbial charge of the oral mucosa epithelium in crack users in in terms of the amount and duration of use. METHODS: Two hundred thirty four crack users (case group) and 120 non-users (control group) participated in this study. Clinically healthy epithelial cells were collected from the posterior mouth floor, using the conventional exfoliative cytology. Some of the aspects evaluated were as follows: Papanicolaou classification, nuclear area (NA), cytoplasmic area (CA), nuclear/cytoplasmic area ratio (NA/CA), inflammation, microbial charge, keratinization, enucleated superficial cells, and binucleation...
March 29, 2017: European Addiction Research
https://www.readbyqxmd.com/read/28351007/catalytic-role-of-iron-in-the-formation-of-silver-nanoparticles-in-photo-irradiated-ag-dissolved-organic-matter-solution
#2
Yongguang Yin, Dan Han, Chao Tai, Zhiqiang Tan, Xiaoxia Zhou, Sujuan Yu, Jingfu Liu, Guibin Jiang
Photo-reduction of Ag(+) to silver nanoparticle (AgNPs) by dissolved organic matter (DOM) is a possible source of naturally occurring AgNPs. However, how this photo-reduction process is influenced by ubiquitous metal ions is still not well understood. In addition, in previous studies, the formation of AgNPs in DOM solution was usually monitored by UV-Vis spectroscopy, and there is still lack of quantitative analysis for the formed AgNPs. In the present study, the role of Fe(2+)/Fe(3+) at environmental concentration level on this photochemical process was investigated, and the enhanced formation of AgNPs by Fe(2+)/Fe(3+) was probed and quantified by using UV-Vis spectroscopy, transmission electron microscopy, and liquid chromatography-inductively coupled plasma mass spectrometry...
March 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28350995/the-difference-in-association-between-aspirin-use-and-other-thrombocyte-aggregation-inhibitors-and-survival-in-patients-with-colorectal-cancer
#3
M A Frouws, E Rademaker, E Bastiaannet, M P P van Herk-Sukel, V E Lemmens, C J H Van de Velde, J E A Portielje, G J Liefers
BACKGROUND: Several studies have suggested that the association between aspirin and improved cancer survival is mediated through the mechanism of aspirin as thrombocyte aggregation inhibitors (TAI). The aim of this study was to provide epidemiological evidence for this mechanism assessing the association between overall survival and the use of aspirin and non-aspirin TAI in patients with colorectal cancer. METHODS: In this observational study, data from the Netherlands Comprehensive Cancer Organisation were linked to PHARMO Database Network...
March 25, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28350633/patient-and-physician-race-and-the-allocation-of-time-and-patient-engagement-efforts-to-mental-health-discussions-in-primary-care-an-observational-study-of-audiorecorded-periodic-health-examinations
#4
Patricia K Foo, Richard M Frankel, Thomas G McGuire, Alan M Zaslavsky, Jennifer Elston Lafata, Ming Tai-Seale
This study investigated racial differences in patient-physician communication around mental health versus biomedical issues. Data were collected from audiorecorded periodic health examinations of adults with mental health needs in the Detroit area (2007-2009). Patients and their primary care physicians conversed for twice as long, and physicians demonstrated greater empathy during mental health topics than during biomedical topics. This increase varied by patient and physician race. Patient race predicted physician empathy, but physician race predicted talk time...
March 27, 2017: Journal of Ambulatory Care Management
https://www.readbyqxmd.com/read/28346766/maternal-thyroid-parameters-in-pregnant-women-with-different-ethnic-backgrounds-do-ethnicity-specific-reference-ranges-improve-the-diagnosis-of-subclinical-hypothyroidism
#5
Flora Veltri, Julie Belhomme, Pierre Kleynen, Lidia Grabczan, Serge Rozenberg, Thierry Pepersack, Kris Poppe
OBJECTIVE: Guidelines on the management of thyroid dysfunction during pregnancy have recently been updated and, for the diagnosis of subclinical hypothyroidism (SCH), a TSH upper reference limit (cutoff) of 4.0 mIU/L has been proposed when no institutional values are available. It is also suggested that serum TSH and thyroid autoimmunity (TAI) may be different according to the ethnic background of the women. We therefore determined the prevalence of TAI and SCH in pregnant women with different ethnic backgrounds and, to define SCH, we used different first trimester TSH upper reference cutoffs (institutional, ethnicity-specific, 2...
March 27, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28346652/treatment-success-with-titratable-thermoplastic-mandibular-advancement-devices-for-obstructive-sleep-apnea-a-comparison-of-patient-characteristics
#6
Tang-Chuan Wang, Yung-An Tsou, Yi-Fan Wu, Chia-Chang Huang, Wesley Wen-Yang Lin, Yu-Fen Li, Michael Yuan-Chien Chen, Chih-Jaan Tai, Ming-Hsui Tsai
A titratable thermoplastic mandibular advancement device (MAD) is clearly an effective treatment option in some patients with obstructive sleep apnea (OSA). Determining which patients may be more likely to respond to treatment with thermoplastic MADs and to adhere to treatment would be of obvious clinical relevance. This was an experimental descriptive study (N = 60). Patients with OSA were instructed to wear a titratable thermoplastic MAD for 3 months. Treatment success was defined as a ≥50% reduction from baseline in the apnea-hypopnea index (AHI) or AHI <10 when wearing MAD...
March 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28345651/epigenome-mapping-highlights-chromatin-mediated-gene-regulation-in-the-protozoan-parasite-trichomonas-vaginalis
#7
Min-Ji Song, Mikyoung Kim, Yeeun Choi, Myung-Hee Yi, Juri Kim, Soon-Jung Park, Tai-Soon Yong, Hyoung-Pyo Kim
Trichomonas vaginalis is an extracellular flagellated protozoan parasite that causes trichomoniasis, one of the most common non-viral sexually transmitted diseases. To survive and to maintain infection, T. vaginalis adapts to a hostile host environment by regulating gene expression. However, the mechanisms of transcriptional regulation are poorly understood for this parasite. Histone modification has a marked effect on chromatin structure and directs the recruitment of transcriptional machinery, thereby regulating essential cellular processes...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28344747/gastric-peritoneal-carcinomatosis-a-retrospective-review
#8
Hwee Leong Tan, Claramae Shulyn Chia, Grace Hwei Ching Tan, Su Pin Choo, David Wai-Meng Tai, Clarinda Wei Ling Chua, Matthew Chau Hsien Ng, Khee Chee Soo, Melissa Ching Ching Teo
AIM: To characterize patients with gastric peritoneal carcinomatosis (PC) and their typical clinical and treatment course with palliative systemic chemotherapy as the current standard of care. METHODS: We performed a retrospective electronic chart review of all patients with gastric adenocarcinoma with PC diagnosed at initial metastatic presentation between January 2010 and December 2014 in a single tertiary referral centre. RESULTS: We studied a total of 271 patients with a median age of 63...
March 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28344732/autonomic-modulation-in-older-women-using-resistance-exercise-as-a-countermeasure
#9
Hayden Gerhart, Yu Lun Tai, Curtis Fennell, Xián Mayo, J Derek Kingsley
It is unclear if resistance training (RT) can be used to alter declines in autonomic modulation associated with aging. Young women (YW; range 18-25 yrs) and older women (OW; range 50-72 yrs) were compared at baseline. Only OW underwent supervised RT 2 days a week for 12-weeks. Baseline and post-training measurements included heart rate variability (HRV) and complexity (Sample Entropy) to assess autonomic modulation. The 12-weeks of RT consisted of 9 exercises performing 3 sets of 8-12 repetitions. At baseline, group differences in maximal strength, and autonomic modulation were evaluated with a one-way ANOVA with BMI as a covariate...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28343893/local-hemostatic-matrix-for-endoscope-assisted-removal-of-intracerebral-hemorrhage-is-safe-and-effective
#10
Hui-Tzung Luh, Abel Po-Hao Huang, Shih-Hung Yang, Chien-Ming Chen, Der-Yang Cho, Chun-Chung Chen, Lu-Ting Kuo, Chieh-Hsun Li, Kuo-Chuan Wang, Wei-Lung Tseng, Ming-Tai Hsing, Bing-Shiang Yang, Dar-Ming Lai, Jui-Chang Tsai
BACKGROUND/PURPOSE: Minimally invasive endoscope-assisted (MIE) evacuation of spontaneous intracerebral hemorrhage (ICH) is simple and effective, but the limited working space may hinder meticulous hemostasis and might lead to rebleeding. Management of intraoperative hemorrhage is therefore a critical issue of this study. This study presents experience in the treatment of patients with various types of ICH by MIE evacuation followed by direct local injection of FloSeal Hemostatic Matrix (Baxter Healthcare Corp, Fremont, CA, USA) for hemostasis...
March 23, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28342686/taiji-tai-chi-for-fall-prevention-in-the-elderly-training-the-trainers-evaluation-project
#11
Lucy Bartimole, Mary A Fristad
Falls in the elderly are common and a major, costly health problem. Taiji addresses many issues related to fall risk. We determined whether intensive weekend training can sufficiently train persons who have baseline familiarity with Taiji to model and teach fundamentals of Taiji to the elderly. Prior to training, registrants received a manual, video and online links for review and practice. Assessments were completed pre-/post-training. Training occurred in four cities of one state. 34 adults completed training, two did not complete evaluations (ns = 12, 13, 4, and 5 at the four sites)...
February 24, 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28341696/a-low-frequency-inactivating-akt2-variant-enriched-in-the-finnish-population-is-associated-with-fasting-insulin-levels-and-type-2-diabetes-risk
#12
Alisa Manning, Heather M Highland, Jessica Gasser, Xueling Sim, Taru Tukiainen, Pierre Fontanillas, Niels Grarup, Manuel A Rivas, Anubha Mahajan, Adam E Locke, Pablo Cingolani, Tune H Pers, Ana Viñuela, Andrew A Brown, Ying Wu, Jason Flannick, Christian Fuchsberger, Eric R Gamazon, Kyle J Gaulton, Hae Kyung Im, Tanya M Teslovich, Thomas W Blackwell, Jette Bork-Jensen, Noël P Burtt, Yuhui Chen, Todd Green, Christopher Hartl, Hyun Min Kang, Ashish Kumar, Claes Ladenvall, Clement Ma, Loukas Moutsianas, Richard D Pearson, John R B Perry, N William Rayner, Neil R Robertson, Laura J Scott, Martijn van de Bunt, Johan G Eriksson, Antti Jula, Seppo Koskinen, Terho Lehtimäki, Aarno Palotie, Olli T Raitakari, Suzanne Br Jacobs, Jennifer Wessel, Audrey Y Chu, Robert A Scott, Mark O Goodarzi, Christine Blancher, Gemma Buck, David Buck, Peter S Chines, Stacey Gabriel, Anette P Gjesing, Christopher J Groves, Mette Hollensted, Jeroen R Huyghe, Anne U Jackson, Goo Jun, Johanne Marie Justesen, Massimo Mangino, Jacquelyn Murphy, Matt Neville, Robert Onofrio, Kerrin S Small, Heather M Stringham, Joseph Trakalo, Eric Banks, Jason Carey, Mauricio O Carneiro, Mark DePristo, Yossi Farjoun, Timothy Fennell, Jacqueline I Goldstein, George Grant, Martin Hrabé de Angelis, Jared Maguire, Benjamin M Neale, Ryan Poplin, Shaun Purcell, Thomas Schwarzmayr, Khalid Shakir, Joshua D Smith, Tim M Strom, Thomas Wieland, Jaana Lindstrom, Ivan Brandslund, Cramer Christensen, Gabriela L Surdulescu, Timo A Lakka, Alex S F Doney, Peter Nilsson, Nicholas J Wareham, Claudia Langenberg, Tibor V Varga, Paul W Franks, Olov Rolandsson, Anders H Rosengren, Vidya S Farook, Farook Thameem, Sobha Puppala, Satish Kumar, Donna M Lehman, Christopher P Jenkinson, Joanne E Curran, Daniel Esten Hale, Sharon P Fowler, Rector Arya, Ralph A DeFronzo, Hanna E Abboud, Ann-Christine Syvänen, Pamela J Hicks, Nicholette D Palmer, Maggie C Y Ng, Donald W Bowden, Barry I Freedman, Tõnu Esko, Reedik Mägi, Lili Milani, Evelin Mihailov, Andres Metspalu, Narisu Narisu, Leena Kinnunen, Lori L Bonnycastle, Amy Swift, Dorota Pasko, Andrew R Wood, João Fadista, Toni I Pollin, Nir Barzilai, Gil Atzmon, Benjamin Glaser, Barbara Thorand, Konstantin Strauch, Annette Peters, Michael Roden, Martina Müller-Nurasyid, Liming Liang, Jennifer Kriebel, Thomas Illig, Harald Grallert, Christian Gieger, Christa Meisinger, Lars Lannfelt, Solomon K Musani, Michael Griswold, Herman A Taylor, Gregory Wilson, Adolfo Correa, Heikki Oksa, William R Scott, Uzma Afzal, Sian-Tsung Tan, Marie Loh, John C Chambers, Jobanpreet Sehmi, Jaspal Singh Kooner, Benjamin Lehne, Yoon Shin Cho, Jong-Young Lee, Bok-Ghee Han, Annemari Käräjämäki, Qibin Qi, Lu Qi, Jinyan Huang, Frank B Hu, Olle Melander, Marju Orho-Melander, Jennifer E Below, David Aguilar, Tien Yin Wong, Jianjun Liu, Chiea-Chuen Khor, Kee Seng Chia, Wei Yen Lim, Ching-Yu Cheng, Edmund Chan, E Shyong Tai, Tin Aung, Allan Linneberg, Bo Isomaa, Thomas Meitinger, Tiinamaija Tuomi, Liisa Hakaste, Jasmina Kravic, Marit E Jørgensen, Torsten Lauritzen, Panos Deloukas, Kathleen E Stirrups, Katharine R Owen, Andrew J Farmer, Timothy M Frayling, Stephen P O'Rahilly, Mark Walker, Jonathan C Levy, Dylan Hodgkiss, Andrew T Hattersley, Teemu Kuulasmaa, Alena Stančáková, Inês Barroso, Dwaipayan Bharadwaj, Juliana Chan, Giriraj R Chandak, Mark J Daly, Peter J Donnelly, Shah B Ebrahim, Paul Elliott, Tasha Fingerlin, Philippe Froguel, Cheng Hu, Weiping Jia, Ronald C W Ma, Gilean McVean, Taesung Park, Dorairaj Prabhakaran, Manjinder Sandhu, James Scott, Rob Sladek, Nikhil Tandon, Yik Ying Teo, Eleftheria Zeggini, Richard M Watanabe, Heikki A Koistinen, Y Antero Kesaniemi, Matti Uusitupa, Timothy D Spector, Veikko Salomaa, Rainer Rauramaa, Colin N A Palmer, Inga Prokopenko, Andrew D Morris, Richard N Bergman, Francis S Collins, Lars Lind, Erik Ingelsson, Jaakko Tuomilehto, Fredrik Karpe, Leif Groop, Torben Jørgensen, Torben Hansen, Oluf Pedersen, Johanna Kuusisto, Gonçalo Abecasis, Graeme I Bell, John Blangero, Nancy J Cox, Ravindranath Duggirala, Mark Seielstad, James G Wilson, Josee Dupuis, Samuli Ripatti, Craig L Hanis, Jose C Florez, Karen L Mohlke, James B Meigs, Markku Laakso, Andrew P Morris, Michael Boehnke, David Altshuler, Mark I McCarthy, Anna L Gloyn, Cecilia M Lindgren
To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together with an additional 390,225 variants from exome sequence in up to 39,339 normoglycemic individuals from five ancestry groups. We identified a novel association between the coding variant (p.Pro50Thr) in AKT2 and fasting insulin, a gene in which rare fully penetrant mutations are causal for monogenic glycemic disorders...
March 24, 2017: Diabetes
https://www.readbyqxmd.com/read/28341199/quantitative-magnetic-resonance-diffusion-weighted-imaging-evaluation-of-the-supratentorial-brain-regions-in-patients-diagnosed-with-brainstem-variant-of-posterior-reversible-encephalopathy-syndrome-a-preliminary-study
#13
Tai-Yuan Chen, Te-Chang Wu, Ching-Chung Ko, I-Jung Feng, Yu-Kun Tsui, Chien-Jen Lin, Jeon-Hor Chen, Ching-Po Lin
BACKGROUND AND PURPOSE: Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiologic entity with several causes, characterized by rapid onset of symptoms and typical neuroimaging features, which usually resolve if promptly recognized and treated. Brainstem variant of PRES presents with vasogenic edema in brainstem regions on magnetic resonance (MR) images and there is sparing of the supratentorial regions. Because PRES is usually caused by a hypertensive crisis, which would likely have a systemic effect and global manifestations on the brain tissue, we thus proposed that some microscopic abnormalities of the supratentorial regions could be detected with diffusion-weighted imaging (DWI) using apparent diffusion coefficient (ADC) analysis in brainstem variant of PRES and hypothesized that "normal-looking" supratentorial regions will increase water diffusion...
March 21, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28341000/arterial-spin-labeling-perfusion-imaging-of-children-with-subdural-hemorrhage-perfusion-abnormalities-in-abusive-head-trauma
#14
Alex Mun-Ching Wong, Chih-Hua Yeh, Ho-Ling Liu, Tai-Wei Wu, Kuang-Lin Lin, Huei-Shyong Wang, Cheng-Hong Toh
BACKGROUND AND PURPOSE: Perfusion abnormalities have not been well described in children with subdural hemorrhage (SDH). We investigated whether patients with abusive head trauma (AHT+) had more perfusion abnormalities than those without (AHT-). MATERIALS AND METHODS: We reviewed the perfusion MR studies of 12 infants with SDH and 21 controls. The perfusion images were obtained using a pseudo-continuous arterial spin-labeling sequence with volumetric fast spin-echo readout...
March 21, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28340860/association-of-pre-hospital-theophylline-use-and-mortality-in-chronic-obstructive-pulmonary-disease-patients-with-sepsis
#15
Yu-Ning Shih, Yung-Tai Chen, Hsi Chu, Chia-Jen Shih, Shuo-Ming Ou, Yen-Tao Hsu, Ran-Chou Chen, Sadeq A Quraishi, Imoigele P Aisiku, Raghu R Seethala, Gyorgy Frendl, Peter C Hou
BACKGROUND: Although theophylline has been shown to have anti-inflammatory effects, the therapeutic use of theophylline before sepsis is unknown. The aim of our study was to determine the effect of theophylline on COPD patients presenting with sepsis. METHODS: This nationwide, population-based, propensity score-matched analysis used data from the linked administrative databases of Taiwan's National Health Insurance program. Patients with COPD who were hospitalized for sepsis between 2000 and 2011 were divided into theophylline users and non-users...
April 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28340751/metal-oxide-based-dispersive-solid-phase-extraction-coupled-with-mass-spectrometry-analysis-for-determination-of-ribose-conjugates-in-human-follicular-fluid
#16
Jie-Mei Chu, Tai-Lang Yin, Shu-Jian Zheng, Jing Yang, Bi-Feng Yuan, Yu-Qi Feng
Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. The pathogenesis of PCOS remains unclear and early diagnosis of PCOS is challenging. Follicular fluid provides a unique window in the critical processes during oocyte and follicular maturation, and the metabolic level of follicular fluid has important impact on the developmental potential of oocytes and subsequent embryos. Previous studies demonstrated some modified ribonucleosides in biological fluids were diseases related metabolites...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28340499/pagan-symbols-associated-with-the-female-anatomy-in-the-medici-chapel-by-michelangelo-buonarroti
#17
Deivis de Campos, Andrea Oxley da Rocha, Rodrigo de Oliveira Lemos, Tais Malysz, João Antonio Bonatto-Costa, Geraldo Pereira Jotz, Lino Pinto de Oliveira Junior, Miriam da Costa Oliveira
Numerous studies have shown that many works of art from the Renaissance period contain hidden symbols and codes that could have religious, mathematical and/or pagan significance and even anatomical allusions. In this context, the present manuscript offers new evidence that the great genius of anatomy, Michelangelo Buonarroti (1475-1564), included pagan symbols associated with female anatomy in the funerary monuments found in the Sagrestia Nuova/Medici Chapel (1519-1533) in Florence, Italy. The interpretation of the symbols provided in this study will interest those with a passion for the history of anatomy...
March 24, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28338671/regulatory-b-cell-myeloma-cell-interaction-confers-immunosuppression-and-promotes-their-survival-in-the-bone-marrow-milieu
#18
L Zhang, Y-T Tai, M Ho, L Xing, D Chauhan, A Gang, L Qiu, K C Anderson
No abstract text is available yet for this article.
March 24, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28338483/prevalence-and-impact-on-weaning-of-pleural-effusion-at-the-time-of-liberation-from-mechanical-ventilation-a-multicenter-prospective-observational-study
#19
Martin Dres, Damien Roux, Tài Pham, Alexandra Beurton, Jean-Damien Ricard, Muriel Fartoukh, Alexandre Demoule
BACKGROUND: Pleural effusion is frequent in intensive care unit patients, but its impact on the outcome of weaning remains unknown. METHODS: In a prospective study performed in three intensive care units, pleural ultrasound was performed at the first spontaneous breathing trial to detect and quantify pleural effusion (small, moderate, and large). Weaning failure was defined by a failed spontaneous breathing trial and/or extubation requiring any form of ventilatory support within 48 h...
March 24, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28338004/tigar-knockdown-radiosensitizes-trxr1-overexpressing-glioma-in-vitro-and-in-vivo-via-inhibiting-trx1-nuclear-transport
#20
Yushuo Zhang, Fei Chen, Guomei Tai, Jiaojiao Wang, Jun Shang, Bing Zhang, Ping Wang, Baoxing Huang, Jie Du, Jiahua Yu, Haowen Zhang, Fenju Liu
The up-regulation of thioredoxin reductase-1 (TrxR1) is detected in more than half of gliomas, which is significantly associated with increased malignancy grade and recurrence rate. The biological functions of NADPH-dependent TrxR1 are mainly associated with reduced thioredoxin-1 (Trx1) which plays critical roles in cellular redox signaling and tumour radio-resistance. Our previous work has proved that TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown could notably radiosensitize glioma cells...
March 24, 2017: Scientific Reports
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