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https://www.readbyqxmd.com/read/28731681/the-first-n-borylated-emitters-displaying-highly-efficient-thermally-activated-delayed-fluorescence-and-high-performance-oleds
#1
Yi-Jyun Lien, Tzu-Chieh Lin, Chun-Chieh Yang, Yu-Cheng Chiang, Chih-Hao Chang, Shih-Hung Liu, Yi-Ting Chen, Gene-Hsiang Lee, Pi-Tai Chou, Chin-Wei Lu, Yun Chi
Despite the fast boom of thermally activated delayed fluorescence (TADF) emitters bearing borane-based acceptor, so far, none of TADF emitters with a direct B-N linkage between N-donor and boryl acceptor has been reported. The latter should simplify molecular architecture and hence facilitate the synthetic design and versatility. We report here the preparation and characterization of a new series of N-borylated compounds with functional acridine donor unit; namely: ACBM, PACBM and SACBM. Spectroscopic studies were performed to explore their photophysical properties that exhibited prominent solvatochromism and thermally activated delayed fluorescence...
July 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28731669/-langerhans-cell-histiocytosis-with-vertebral-involvement-and-soft-tissue-extension-clinical-case
#2
Tai C Luong, Adriana Scrigni, Marcela Paglia, Mariano Garavaglia, Nuria Aisenberg, Hernán Rowensztein, Claudia Sampor
Langerhans cell histiocytosis is a heterogeneous disease of unknown etiology characterized by proliferation of Langerhans cells. It is a rare disease. Bone involvement is common but vertebral disease is rare. We present a 4 year old patient with abdominal pain and neurologic symptoms. Magnetic resonance showed vertebra plana in D9 with involvement of paravertebral soft tissues. The child underwent surgery for decompression and biopsy. Biopsy confirmed Langerhans cell histiocytosis. She was treated with vinblastine and prednisone during 6 months following LCH-III with complete recovery of neurologic symptoms...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28731271/ultrasound-elastography-for-carpal-tunnel-pressure-measurement-a-cadaveric-validation-study
#3
Kazutoshi Kubo, Boran Zhou, Yu-Shiuan Cheng, Tai-Hua Yang, Bo Qiang, Kai-Nan An, Steven L Moran, Peter C Amadio, Xiaoming Zhang, Chunfeng Zhao
Carpal tunnel pressure is a key factor in the etiology of carpal tunnel syndrome. Numerous approaches have been conducted to measure carpal tunnel pressure. However, most techniques are invasive and take time and effort. We have developed an innovative approach to noninvasively assess the tunnel pressure by using the ultrasound surface wave elastography (USWE) technique. In a previous study it was shown that the shear wave speed in a tendon increased linearly with increasing tunnel pressure enclosed the tendon in a simple tendon model...
July 21, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28731159/ganoderic-acid-a-inhibits-proliferation-and-invasion-and-promotes-apoptosis-in-human-hepatocellular-carcinoma-cells
#4
Xu Wang, Di Sun, Jiandong Tai, Lei Wang
Ganoderic acid A (GA‑A), a triterpenoid, has been demonstrated to suppress cell proliferation in various cancers, including breast cancer and osteosarcoma. However, its effect on human hepatocellular carcinoma (HCC) remains to be elucidated. The present study aimed to investigate the effect of GA‑A on HCC cells in vitro. The HepG2 and SMMC7721 human HCC cell lines were treated with differing concentrations of GA‑A for 24, 48 and 72 h. The cell growth rate, cell cycle and apoptosis, migration and invasion were determined using a Cell Counting Kit‑8, flow cytometry and transwell assays, respectively...
July 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28730900/falls-prevention-interventions-for-older-adults-with-low-vision-a-scoping-review-%C3%A3-tude-de-port%C3%A3-e-sur-les-interventions-visant-%C3%A3-pr%C3%A3-venir-les-chutes-chez-les-a%C3%A3-n%C3%A3-s-ayant-une-basse-vision
#5
Sarah E Blaylock, Laura K Vogtle
BACKGROUND: Older adults with low vision are especially vulnerable to falls. There are no comprehensive reviews of fall prevention interventions for older adults with vision loss who live in the community. PURPOSE: The aim of this study was to review the evidence regarding community-based falls prevention interventions that appear inclusive of and/or accessible to individuals with low vision. METHOD: A scoping review was completed using the framework developed by Arksey and O'Malley, and the charted data were analyzed using sums and percentages and qualitative content analysis...
June 2017: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
https://www.readbyqxmd.com/read/28729104/no-225-management-guidelines-for-obstetric-patients-and-neonates-born-to-mothers-with-suspected-or-probable-severe-acute-respiratory-syndrome-sars
#6
Cynthia Maxwell, Alison McGeer, Kin Fan Young Tai, Mathew Sermer
OBJECTIVE: This document summarizes the limited experience of SARS in pregnancy and suggests guidelines for management. OUTCOMES: Cases reported from Asia suggest that maternal and fetal outcomes are worsened by SARS during pregnancy. EVIDENCE: Medline was searched for relevant articles published in English from 2000 to 2007. Case reports were reviewed and expert opinion sought. VALUES: Recommendations were made according to the guidelines developed by the Canadian Task Force on Preventive Health Care...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28729103/n-o-225-lignes-directrices-quant-%C3%A3-la-prise-en-charge-des-patientes-en-obst%C3%A3-trique-chez-lesquelles-la-pr%C3%A3-sence-du-syndrome-respiratoire-aigu-s%C3%A3-v%C3%A3-re-sras-est-soup%C3%A3-onn%C3%A3-e-ou-probable-et-des-nouveau-n%C3%A3-s-issus-de-ces-patientes
#7
Cynthia Maxwell, Alison McGeer, Kin Fan Young Tai, Mathew Sermer
OBJECTIF: Le présent document résume notre expérience limitée quant à la présence du SRAS pendant la grossesse et suggère des lignes directrices quant à sa prise en charge. ISSUES: Les exposés de cas issus d'Asie laissent entendre que les issues maternelles et fœtales sont aggravées par la présence du SRAS pendant la grossesse. RéSULTATS: Des recherches ont été menées dans Medline afin d'en tirer les articles pertinents publiés en anglais entre 2000 et 2007...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28728863/a-mechanistic-force-model-for-simulating-haptics-of-hand-held-bone-burring-operations
#8
Avinash Danda, Mathew A Kuttolamadom, Bruce L Tai
This paper presents a mechanistic model to predict the forces experienced during bone burring with application to haptic feedback for virtual reality surgical simulations. Bone burring is a hand-held operation where the force perceived by the surgeon depends on the cutting tool orientation and motion. The model of this study adapted the concept of specific cutting energy and material removal rate based on machining theory to calculate force distribution on the spherical tool surface in a three-dimensional setting...
July 17, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28728755/-magnetic-resonance-in-traumatic-brain-injury-a-comparative-study-of-the-different-conventional-magnetic-resonance-imaging-sequences-and-their-diagnostic-value-in-diffuse-axonal-injury
#9
Marta Cicuendez, Ana Castaño-León, Ana Ramos, Amaya Hilario, Pedro A Gómez, Alfonso Lagares
OBJECTIVE: To compare the identification capability of traumatic axonal injury (TAI) by different sequences on conventional magnetic resonance (MR) studies in traumatic brain injury (TBI) patients. MATERIAL AND METHODS: We retropectevely analyzed 264 TBI patients to whom a MR had been performed in the first 60 days after trauma. All clinical variables related to prognosis were registered, as well as the data from the initial computed tomography. The MR imaging protocol consisted of a 3-plane localizer sequence T1-weighted and T2-weighted fast spin-echo, FLAIR and gradient-echo images (GRET2*)...
July 17, 2017: Neurocirugía
https://www.readbyqxmd.com/read/28727557/integrating-flexible-sensor-and-virtual-self-organizing-dc-grid-model-with-cloud-computing-for-blood-leakage-detection-during-hemodialysis
#10
Ping-Tzan Huang, Tai-Lang Jong, Chien-Ming Li, Wei-Ling Chen, Chia-Hung Lin
Blood leakage and blood loss are serious complications during hemodialysis. From the hemodialysis survey reports, these life-threatening events occur to attract nephrology nurses and patients themselves. When the venous needle and blood line are disconnected, it takes only a few minutes for an adult patient to lose over 40% of his / her blood, which is a sufficient amount of blood loss to cause the patient to die. Therefore, we propose integrating a flexible sensor and self-organizing algorithm to design a cloud computing-based warning device for blood leakage detection...
July 18, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28726350/what-is-distressing-about-auditory-verbal-hallucinations-the-contribution-of-goal-interference-and-goal-facilitation
#11
Filippo Varese, Warren Mansell, Sara J Tai
OBJECTIVES: Distressing and pleasant/positive voices (auditory verbal hallucinations) are common in both clinical and non-clinical voice-hearers. Identifying factors that contribute to emotional reactions to voices is essential for developing effective psychological interventions. Several theories propose that facilitation and interference with personal goals are important predictors of distress and well-being. This study examined whether voice-related distress is related to the degree to which voices interfere with personal goals, and whether pleasantness of voices is influenced by the extent to which they facilitate goals...
July 20, 2017: Psychology and Psychotherapy
https://www.readbyqxmd.com/read/28726259/characterization-of-adenoviral-transduction-profile-in-prostate-cancer-cells-and-normal-prostate-tissue
#12
Jianzhong Ai, Phillip W L Tai, Yi Lu, Jia Li, Hong Ma, Qin Su, Qiang Wei, Hong Li, Guangping Gao
BACKGROUND: Prostate diseases are common in males worldwide with high morbidity. Gene therapy is an attractive therapeutic strategy for prostate diseases, however, it is currently underdeveloped. As well known, adeno virus (Ad) is the most widely used gene therapy vector. The aims of this study are to explore transduction efficiency of Ad in prostate cancer cells and normal prostate tissue, thus further providing guidance for future prostate pathophysiological studies and therapeutic development of prostate diseases...
July 20, 2017: Prostate
https://www.readbyqxmd.com/read/28725493/interferon-alpha-based-immunotherapies-in-the-treatment-of-b-cell-derived-hematologic-neoplasms-in-today-s-treat-to-target-era
#13
REVIEW
Li Zhang, Yu-Tzu Tai, Matthew Zhi Guang Ho, Lugui Qiu, Kenneth C Anderson
B cell lymphoma and multiple myeloma (MM) are the most common hematological malignancies which benefit from therapeutic monoclonal antibodies (mAbs)-based immunotherapies. Despite significant improvement on patient outcome following the use of novel therapies for the past decades, curative treatment is unavailable for the majority of patients. For example, the 5-year survival of MM is currently less than 50%. In the 1980s, interferon-α was used as monotherapy in newly diagnosed or previously treated MM with an overall response rate of 15-20%...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/28724901/real-time-and-label-free-chemical-sensor-on-a-chip-using-monolithic-si-on-batio3-mid-infrared-waveguides
#14
Tiening Jin, Leigang Li, Bruce Zhang, Hao-Yu Greg Lin, Haiyan Wang, Pao Tai Lin
Chip-scale chemical detection is demonstrated by using mid-Infrared (mid-IR) photonic circuits consisting of amorphous silicon (a-Si) waveguides on an epitaxial barium titanate (BaTiO3, BTO) thin film. The highly c-axis oriented BTO film was grown by the pulsed laser deposition (PLD) method and it exhibits a broad transparent window from λ = 2.5 μm up to 7 μm. The waveguide structure was fabricated by the complementary metal-oxide-semiconductor (CMOS) process and a sharp fundamental waveguide mode has been observed...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724891/hypoxia-inducible-factor-1-alpha-is-involved-in-rip-induced-necroptosis-caused-by-in-vitro-and-in-vivo-ischemic-brain-injury
#15
Xiao-Sa Yang, Tai-Long Yi, Sai Zhang, Zhong-Wei Xu, Ze-Qi Yu, Hong-Tao Sun, Cheng Yang, Yue Tu, Shi-Xiang Cheng
Necroptosis, a novel type of programmed cell death, is involved in stroke-induced ischemic brain injury. Although studies have sought to explore the mechanisms of necroptosis, its signaling pathway has not yet to be completely elucidated. Thus, we used oxygen-glucose deprivation (OGD) and middle cerebral artery occlusion (MCAO) models mimicking ischemic stroke (IS) conditions to investigate mechanisms of necroptosis. We found that OGD and MCAO induced cell death, local brain ischemia and neurological deficit, while zVAD-fmk (zVAD, an apoptotic inhibitor), GSK'872 (a receptor interacting protein kinase-3 (RIP3) inhibitor), and combined treatment alleviated cell death and ischemic brain injury...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724298/definitions-of-healing-and-healing-interventions-across-different-cultures
#16
Ann H Lichtenstein, Ann Berger, M Jennifer Cheng
For centuries healing has been embedded in non-Western cultures. Traditional cultures believe that healing is derived from the divine and utilize a holistic approach to healing including the body, mind, and spirit. The community and environment are key elements in individual healing along with herbal remedies and ceremonies. Western cultures have accepted some traditional methods of relaxation and exercise, such as yoga and tai chi. In this paper we will examine some similar themes of traditional practices to better understand traditional patients' healing paradigm and find new tools as practitioners of Western medicine...
July 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28723753/tumor-necrosis-factor-alpha-238g-a-polymorphism-and-risk-of-breast-cancer-an-update-by-meta-analysis
#17
Qing Zhang, Guang Sheng Zhao, Xiao Lin Yuan, Xiao Huan Li, Zhen Yang, Yi Fen Cui, Qing Lin Guan, Xiu Yan Sun, Wan Shen, Tai An Xu, Qiu Shi Wang
BACKGROUND: The association between the tumor necrosis factor-alpha gene (TNF-a) -238G/A polymorphism and the breast cancer has been analyzed in several studies, but the results have been inconclusive. We then performed a meta-analysis to get a precise estimation of the association. METHODS: Eight case-control studies with a total of 37,257 cases and 39,564 controls were identified by searching the ISI Web of Knowledge database and the PubMed database up to August 2014...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28722670/follicular-metabolic-changes-and-effects-on-oocyte-quality-in-polycystic-ovary-syndrome-patients
#18
Yan Zhang, Lingyan Liu, Tai-Lang Yin, Jing Yang, Cheng-Liang Xiong
Polycystic ovary syndrome (PCOS) is a common complex and heterogeneous disorder, affecting up to 10% women at reproductive age. It causes three fourth of the ovulatory infertility and PCOS patients often give poor IVF quality. Although some metabolic profiles have been investigated in PCOS patient sera and urine, the follicular fluid, providing fruitful biochemical information about oocyte environment during development has been ignored. In this work, based on NMR metabolomics approach, metabolic profile of follicular fluid of PCOS patients has been explored and compared with healthy controls...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722394/direct-electrospray-printing-of-gradient-refractive-index-chalcogenide-glass-films
#19
Spencer Novak, Pao Tai Lin, Cheng Li, Chatdanai Lumdee, Juejun Hu, Anuradha Murthy Agarwal, Pieter G Kik, Weiwei Deng, Kathleen Richardson
A spatially varying effective refractive index gradient using chalcogenide glass layers is printed on a silicon wafer using an optimized electrospray (ES) deposition process. Using solution-derived glass precursors, infrared transparent Ge23Sb7S70 and As40S60 glass films of programmed thickness are fabricated to yield a bilayer structure resulting in an effective gradient refractive index (GRIN) film. Optical and compositional analysis tools confirm the optical and physical nature of the gradient in the resulting high optical quality films, demonstrating the power of direct printing of multi-material structures compatible with planar photonic fabrication protocols...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28721726/3d-printed-earable-smart-devices-for-real-time-detection-of-core-body-temperature
#20
Hiroki Ota, Minghan Chao, Yuji Gao, Eric Wu, Li-Chia Tai, Kevin Chen, Yasutomo Matsuoka, Kosuke Iwai, Hossain M Fahad, Wei Gao, Hnin Yin Yin Nyein, Liwei Lin, Ali Javey
Real-time detection of basic physiological parameters such as blood pressure and heart rate is an important target in wearable smart devices for healthcare. Among these, the core body temperature is one of the most important basic medical indicators of fever, insomnia, fatigue, metabolic functionality, and depression. However, traditional wearable temperature sensors are based upon the measurement of skin temperature, which can vary dramatically from the true core body temperature. Here, we demonstrate a three-dimensional (3D) printed wearable "earable" smart device that is designed to be worn on the ear to track core body temperature from the tympanic membrane (i...
July 19, 2017: ACS Sensors
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