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https://www.readbyqxmd.com/read/29908100/exosomes-in-cancer-development-and-clinical-applications
#1
REVIEW
Yu-Ling Tai, Ko-Chien Chen, Jer-Tsong Hsieh, Tang-Long Shen
Exosomes participate in cancer progression and metastasis by transferring bioactive molecules between cancer and varied cells in the local and distant microenvironments. Such intercellular cross-talks result in changes in multiple cellular and biological functions in recipient cells. Several hallmarks of cancer have been reportedly impacted by this exosome-mediated cell-to-cell communication, including modulating immune responses, re-programming stromal cells, re-modeling the architecture of extracellular matrix, or even endowing cancer cells with characteristics of drug resistance...
June 16, 2018: Cancer Science
https://www.readbyqxmd.com/read/29907268/asynchrony-consequences-and-management
#2
REVIEW
Tài Pham, Irene Telias, Thomas Piraino, Takeshi Yoshida, Laurent J Brochard
Poor synchrony between the delivery of mechanical breaths, the neural respiratory timing, and needs of patients is relatively frequent under mechanical ventilation in the intensive care unit. This review summarizes the current knowledge on the different types of dyssynchrony described to date, their mechanism, consequences, and potential management. There is still a long way to get to a comprehensive knowledge and uncertainties remain. Ongoing research and development of monitoring tools are urgently needed to allow a better appraisal of this area in a near future...
July 2018: Critical Care Clinics
https://www.readbyqxmd.com/read/29907118/cervical-lordosis-in-asymptomatic-individuals-a-meta-analysis
#3
Guang-Ming Guo, Jun Li, Qing-Xun Diao, Tai-Hang Zhu, Zhong-Xue Song, Yang-Yang Guo, Yan-Zheng Gao
BACKGROUND: Cervical lordosis has important clinical and surgical implications. Cervical spine curvature is reported with considerable variability in individual studies. The aim of this study was to examine the existence and extent of cervical lordosis in asymptomatic individuals and to evaluate its relationship with age and gender. METHODS: A comprehensive literature search was conducted in several electronic databases. Study selection was based on pre-determined eligibility criteria...
June 15, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29906665/reproductive-performance-of-bos-indicus-beef-cows-treated-with-different-doses-of-equine-chorionic-gonadotropin-at-the-end-of-a-progesterone-estrogen-based-protocol-for-fixed-time-artificial-insemination
#4
Rafael Herrera Alvarez, Guilherme Pugliesi, Fabio Luis Nogueira Natal, Cecilia Constantino Rocha, Gilmar Arantes Ataide Júnior, Alfredo José Ferreira Melo, Ivani Posar Otzuk, Claudio Alvarenga de Oliveira, Patrice Humblot
Two experiments were performed to evaluate the reproductive performance of zebu beef cows treated with different doses of eCG at the end of a progesterone (P4)/estrogen based protocol for timed artificial insemination (TAI). In Experiment 1, suckling Bos indicus Nelore cows (n = 261) received, on day 0, a progesterone (P4) intravaginal device (PD) and an injection of 1 mg estradiol benzoate (EB). On day 8, the PD was removed, 500 μg of cloprostenol was injected, and cows were assigned to one of the following groups: Control (no treatment), 300 (300 IU of eCG), 600 (600 IU of eCG), and 900 (900 IU of eCG)...
June 8, 2018: Theriogenology
https://www.readbyqxmd.com/read/29906246/o-glycosylation-mediated-signaling-circuit-drives-metastatic-castration-resistant-prostate-cancer
#5
Sheue-Fen Tzeng, Chin-Hsien Tsai, Tai-Kuang Chao, Yu-Ching Chou, Yu-Chih Yang, Mong-Hsun Tsai, Tai-Lung Cha, Pei-Wen Hsiao
Disseminated castration-resistant prostate cancer (CRPC) is a common disease in men that is characterized by limited survival and resistance to androgen-deprivation therapy. The increase in human epidermal growth factor receptor 2 (HER2) signaling contributes to androgen receptor activity in a subset of patients with CRPC; however, enigmatically, HER2-targeted therapies have demonstrated a lack of efficacy in patients with CRPC. Aberrant glycosylation is a hallmark of cancer and involves key processes that support cancer progression...
June 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29906242/angiotensin-ii-receptor-i-blockade-prevents-stenosis-of-tissue-engineered-vascular-grafts
#6
Juan de Dios Ruiz-Rosado, Yong-Ung Lee, Nathan Mahler, Tai Yi, Frank Robledo-Avila, Diana Martinez-Saucedo, Avione Y Lee, Toshihiro Shoji, Eric Heuer, Andrew R Yates, Jordan S Pober, Toshiharu Shinoka, Santiago Partida-Sanchez, Christopher K Breuer
We previously developed a tissue-engineered vascular graft (TEVG) made by seeding autologous cells onto a biodegradable tubular scaffold, in an attempt to create a living vascular graft with growth potential for use in children undergoing congenital heart surgery. Results of our clinical trial showed that the TEVG possesses growth capacity but that its widespread clinical use is not yet advisable due to the high incidence of TEVG stenosis. In animal models, TEVG stenosis is caused by increased monocytic cell recruitment and its classic ("M1") activation...
June 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29905798/nicotine-induced-conditional-place-preference-is-affected-by-head-injury-correlation-with-dopamine-release-in-the-nucleus-accumbens-shell
#7
Chen Yuan-Hao, Tung-Tai Kuo, Eagle Yi-Kung Huang, Barry J Hoffer, Jen-Hsin Kao, Yu-Ching Chou, Yung-Hsiao Chiang, Jonathan Miller
Background: Traumatic brain injury (TBI) is known to impact dopamine-mediated reward pathways, but the underlying mechanisms have not been fully established. Methods: Nicotine-induced conditional place preference (CPP) was used to study rats exposed to a 6-psi fluid percussion injury (FPI) with and without prior exposure to nicotine. Preference was quantified as a score defined as (C1-C2) / (C1+C2), where C1 is time in the nicotine-paired compartment and C2 is time in the saline-paired compartment...
June 14, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29905616/implementation-of-perioperative-music-using-the-consolidated-framework-for-implementation-research
#8
Jessica E Carter, Srinivas Pyati, Frances A Kanach, Ann Miller W Maxwell, Charles M Belden, Christopher M Shea, Thomas Van de Ven, Jillian Thompson, Helen Hoenig, Karthik Raghunathan
BACKGROUND: Complementary integrative health therapies have a perioperative role in the reduction of pain, analgesic use, and anxiety, and increasing patient satisfaction. However, long implementation lags have been quantified. The Consolidated Framework for Implementation Research (CFIR) can help mitigate this translational problem. METHODS: We reviewed evidence for several nonpharmacological treatments (CFIR domain: characteristics of interventions) and studied external context and organizational readiness for change by surveying providers at 11 Veterans Affairs (VA) hospitals (domains: outer and inner settings)...
June 12, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29905422/the-effects-of-tai-chi-exercise-on-bone-mineral-density-in-postmenopausal-women
#9
Bao-Cheng Xie, Shi-Chun Chen, Jia-Huan Wu, Qing-Hui Wang, Chen-Hui Zhou, Dao-Hua Xu
No abstract text is available yet for this article.
June 14, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29905033/green-layer-by-layer-method-for-the-preparation-of-polyacrylonitrile-supported-zn-bdc-membranes
#10
Hui Min Tham, Susilo Japip, Dan Hua, Tai-Shung Chung
Ultrafiltration-level polyacrylonitrile (PAN) flat sheet membranes were chemically modified via cross-linking and hydrolysis to provide a suitable surface for the growth of a selective layer composed of Zn-benzene-1,4-dicarboxylic acid (Zn(BDC)) metal-organic framework (MOF). Unlike typical membrane modification methods or conventional MOF synthesis procedures, deionized (DI) water was the only solvent used for each of the modification steps involved. To better understand the layer-by-layer MOF growth, several MOF growth conditions were also studied, including the effects of solution concentration, growth temperature, membrane immersion time and the number of layers...
June 14, 2018: ChemSusChem
https://www.readbyqxmd.com/read/29904067/cdkn2a-inhibits-formation-of-homotypic-cell-in-cell-structures
#11
Jianqing Liang, Jie Fan, Manna Wang, Zubiao Niu, Zhengrong Zhang, Long Yuan, Yanhong Tai, Zhaolie Chen, Santai Song, Xiaoning Wang, Xiaoqing Liu, Hongyan Huang, Qiang Sun
Cell-in-cell (CIC) structures, characterized by enclosure of one or more cells within another cell, were extensively documented in human cancers. Although elevated CIC formation was found in cancers with CDKN2A inactivation, a causal link between them remains to be established. We reported here that inhibiting CDKN2A expression effectively promoted homotypic CIC formation, whereas ectopic overexpression of p16INK4a or p14ARF, two proteins encoded by CDKN2A gene, significantly suppressed CIC formation in MCF7 cells...
June 5, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29903991/synergistic-antitumor-effect-of-oligogalacturonides-and-cisplatin-on-human-lung-cancer-a549-cells
#12
Cian-Song Huang, Ai-Chun Huang, Ping-Hsiu Huang, Diana Lo, Yuh-Tai Wang, Ming-Chang Wu
Cisplatin (DPP), a clinically potent antineoplastic agent, is limited by its severe adverse effects. The aim of this study was to investigate the effect of oligogalacturonides (OGA) and DDP on human lung cancer A549 cells. The combined use of OGA and DDP had a synergistic effect on the growth inhibition of A549 cells, changed the cell cycle distribution, and enhanced apoptotic response, especially in sequential combination treatment group of DDP 12 h + OGA 12 h. Western blot analyses showed that the combination treatment of OGA and DDP upregulated Bax, p53, and Caspase-3 and downregulated Bcl-2 proteins...
June 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29902497/micrornas-and-diabetic-kidney-disease-systematic-review-and-bioinformatic-analysis
#13
REVIEW
Taís S Assmann, Mariana Recamonde-Mendoza, Bianca M de Souza, Andrea C Bauer, Daisy Crispim
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Emerging evidence has suggested a role for miRNAs in the development of diabetic kidney disease (DKD), indicating that miRNAs may represent potential biomarkers of this disease. However, results are still inconclusive. Therefore, we performed a systematic review of the literature on the subject, followed by bioinformatic analysis. PubMed and EMBASE were searched to identify all studies that compared miRNA expressions between patients with DKD and diabetic patients without this complication or healthy subjects...
June 11, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29898881/personalised-nutrition-and-health
#14
Jose M Ordovas, Lynnette R Ferguson, E Shyong Tai, John C Mathers
No abstract text is available yet for this article.
June 13, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29898190/obsessive-compulsive-symptoms-in-children-with-first-degree-relatives-diagnosed-with-obsessive-compulsive-disorder
#15
Priscila Chacon, Elisa Bernardes, Lívia Faggian, Marcelo Batistuzzo, Tais Moriyama, Eurípedes C Miguel, Guilherme V Polanczyk
OBJECTIVE: A first-degree relative affected by obsessive-compulsive disorder (OCD) and obsessive-compulsive symptoms (OCS) in childhood is an important risk factor for developing the disorder in adulthood. The relationship between a family history of OCD and the presence of OCS and its correlates in childhood is not well established. METHODS: A total of 66 children whose parents or siblings have been diagnosed with OCD were assessed for the presence of OCS and clinical correlates...
June 11, 2018: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29897660/tuning-the-conformation-and-color-of-conjugated-polyheterocyclic-skeletons-by-installing-ortho-methyl-groups
#16
Zhiyun Zhang, Chi-Lin Chen, Yi-An Chen, Yu-Chen Wei, Jianhua Su, He Tian, Pi-Tai Chou
ortho-Methyl effects are exploited to tune steric hindrance between side-chain N,N´-diaryls and polycyclic dihydrodibenzo[a,c]phenazine, and in turn control the conformations of N,N´-diphenyl-dihydrodibenzo[a,c]phenazine (DPAC) and its ortho-methyl(s) derivatives Mx-My (x = 0, 1 or 2, y = 1 or 2, x and y correlate with the number of methyl groups in the ortho-sites of N,N´-diphenyl). The magnitude of steric hindrance increases as x and y increase, and the V-shaped dihydrodibenzo[a,c]phenazine skeleton is gradually tuned from bent (DPAC) to planar (M2-M2) structure in the ground state...
June 13, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29897066/the-effect-of-cis-trans-configurational-difference-on-the-performance-of-pyridylimine-based-ruthenium-sensitizers
#17
Yogesh S Tingare, Suri Babu Akula, Ming-Tai Shen, Chaochin Su, Shih-Yu Ho, Sheng-Han Tsai, Ya-Fen Lin, Wen-Ren Li
New heteroleptic Ru(ii) complexes consisting of pyridylimine as an ancillary ligand were synthesized and characterized for applications in dye sensitized solar cells. Complexes with cis and trans configurations around the central ruthenium metal were obtained using simple synthetic protocols by varying the substituents on the pyridylimine ligands. The geometries of these complexes were confirmed by single crystal X-ray analysis. The effect of the difference in the configurations of these complexes on their device performances was studied and the sensitizer with a trans arrangement around the metal showed a higher overall conversion efficiency (η) of 7...
June 13, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29896594/a-silver-metal-complex-as-a-luminescent-probe-for-enzymatic-sensing-of-glucose-in-blood-plasma-and-urine
#18
Zheng-Bang Pan, Ying-Chu Wang, Gomathy Chakkaradhari, Jian Fan Zhu, Rong-Yu He, Yu-Ci Liu, Chia-Hui Hsu, Igor O Koshevoy, Pi-Tai Chou, Sheng-Wei Pan, Mei-Lin Ho
In this work, we present a facile preparation of a paper-based glucose assay for rapid, sensitive, and quantitative measurement of glucose in blood plasma and urine. Two copper phosphorescent complexes [Cu(2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline)(2,6-dimethylphenylisocyanide)2][B(C6H3(CF3)2)4] (Cu1) and [Cu(2,9-dimethyl-1,10-phenanthroline)(2,6-dimethylphenylisocyanide)2][B(C6H3(CF3)2)4] (Cu2) and a new silver congener [Ag(P3)CNAg(P3)][B(C6H3(CF3)2)4] (Ag3) (P3 = PPh2C6H4-PPh-C6H4PPh2 [bis(o-diphenylphosphinophenyl)phenylphosphine]) have been synthesized and their oxygen sensing abilities were investigated...
June 13, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29895415/white-matter-abnormalities-of-the-tapetum-and-their-associations-with-duration-of-untreated-psychosis-and-symptom-severity-in-first-episode-psychosis
#19
Sun Woo Lee, Arira Lee, Tai Kiu Choi, Borah Kim, Kang-Soo Lee, Minji Bang, Sang-Hyuk Lee
No abstract text is available yet for this article.
June 9, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29895331/immunocompromised-patients-with-acute-respiratory-distress-syndrome-secondary-analysis-of-the-lung-safe-database
#20
Andrea Cortegiani, Fabiana Madotto, Cesare Gregoretti, Giacomo Bellani, John G Laffey, Tai Pham, Frank Van Haren, Antonino Giarratano, Massimo Antonelli, Antonio Pesenti, Giacomo Grasselli
BACKGROUND: The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. METHODS: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents...
June 12, 2018: Critical Care: the Official Journal of the Critical Care Forum
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