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https://www.readbyqxmd.com/read/29454015/why-i-eat-at-night-a-qualitative-exploration-of-the-development-maintenance-and-consequences-of-night-eating-syndrome
#1
James A Shillito, James Lea, Stephanie Tierney, Jacqueline Cleator, Sara Tai, John P H Wilding
Night Eating Syndrome (NES), as a diagnosis, presents as a combination of disordered eating, sleep and mood. Patients identified as having both NES and obesity demonstrate poorer outcomes in terms of weight loss compared to those with NES only. However, research focusing on psychological factors associated with NES remains relatively underdeveloped. This study aimed to explore the relationship between NES and the experience of emotion from the perspective of patients accessing a weight management service. Ten adults who met diagnostic criteria for moderate or full NES took part in a semi-structured interview...
February 14, 2018: Appetite
https://www.readbyqxmd.com/read/29453721/fenton-treatment-of-bio-treated-fermentation-based-pharmaceutical-wastewater-removal-and-conversion-of-organic-pollutants-as-well-as-estimation-of-operational-costs
#2
Yunqin Cheng, Yunlu Chen, Juncheng Lu, Jianxin Nie, Yan Liu
The Fenton process is used as a tertiary treatment to remove organic pollutants from the effluent of bio-treated pharmaceutical wastewater (EBPW). The optimal and most appropriate Fenton conditions were determined by an orthogonal array test and single-factor experiments. The removal of chemical oxygen demand (COD) was influenced by the following factors in a descending order: H 2 O 2 /Fe(II) molar ratio > H 2 O 2 dosage > reaction time. Under the most appropriate Fenton conditions (H 2 O 2 /Fe(II) molar ratio of 1:1, H 2 O 2 dosage of 120 mg L -1 and reaction time of 10 min), the COD and dissolved organic carbon (DOC) were removed with efficiencies of 62 and 53%, respectively, which met the national discharge standard (GB 21903-2008) for the Lake Tai Basin, China...
February 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29453177/association-of-dioxin-exposure-and-reproductive-hormone-levels-in-men-living-near-the-bien-hoa-airbase-vietnam
#3
Hoang Van Luong, Pham The Tai, Muneko Nishijo, Do Minh Trung, Pham Ngoc Thao, Pham Van Son, Nguyen Van Long, Nguyen Tung Linh, Hisao Nishijo
Dioxins are endocrine-disrupting chemicals, and their effects on reproductive functions are well-documented. The aim of the present study was to measure the levels of reproductive hormones in 42 men residing near a dioxin-contaminated area in Vietnam. We measured levels of 17 2,3,7,8-substituted congeners of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) and four non-ortho polychlorinated biphenyls (PCBs) in blood. Levels of follicle-stimulating hormone, luteinizing hormone, progesterone, prolactin, estradiol, and total testosterone were measured in serum...
February 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29452695/the-combination-of-maltose-binding-protein-and-bcg-induced-th1-activation-is-involved-in-tlr2-9-mediated-upregulation-of-myd88-traf6-and-tlr4-mediated-downregulation-of-trif-traf3
#4
Guomu Liu, Xiaoyu Zhai, Hongyue Zhou, Xiaoyu Yang, Nannan Zhang, Guixiang Tai, Weihua Ni
Our previous study demonstrated that maltose-binding protein (MBP) activated Th1 through the TLR2-mediated MyD88-dependent pathway and the TLR4-mediated TRIF-dependent pathway. The combination of MBP and BCG synergistically induced Th1 activation, and the TLR2/9-mediated MyD88-dependent pathway is involved in this process. To further explore this mechanism, we stimulated purified mouse CD4 + T cells with MBP and BCG in vitro. The results demonstrated that MBP combined with BCG synergistically increased IFN-γ production and TLR2/4/9 expression, suggesting the involvement of TLR2/4/9 in the combination-induced Th1 activation...
February 12, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29452397/cohort-profile-the-singapore-multi-ethnic-cohort-mec-study
#5
Kristin Hui Xian Tan, Linda Wei Lin Tan, Xueling Sim, E Shyong Tai, Jeannette Jen-Mai Lee, Kee Seng Chia, Rob M van Dam
No abstract text is available yet for this article.
February 13, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29450504/association-of-adenotonsillectomy-with-blood-pressure-among-hypertensive-and-nonhypertensive-children-with-obstructive-sleep-apnea
#6
Cho-Hsueh Lee, Kun-Tai Kang, Shuenn-Nan Chiu, I-Sheng Chang, Wen-Chin Weng, Pei-Lin Lee, Wei-Chung Hsu
Importance: Hypertension in childhood may continue into adulthood and lead to adverse cardiovascular outcomes. Evidence suggests that adenotonsillectomy for childhood obstructive sleep apnea (OSA) may be associated with blood pressure (BP) improvement. However, how adenotonsillectomy is associated with BP in hypertensive and nonhypertensive children with OSA remains unclear. Objective: To investigate disparities in BP changes after adenotonsillectomy in hypertensive and nonhypertensive children with OSA...
February 15, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29450475/a-woman-with-confusion-and-blurred-vision
#7
Pei Fang Neoh, Evelyn L M Tai, Liza Sharmini Ahmad Tajudin
No abstract text is available yet for this article.
February 15, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29450196/recruitment-and-lessons-learned-from-a-community-based-intervention-program-the-learning-families-project-in-hong-kong
#8
Joanna T W Chu, Alice Wan, Sunita M Stewart, Kwok Tung Ng, Tai Hing Lam, Sophia S Chan
Background: Recruitment is central to any research project, and recruitment itself should be well documented and researched. We describe our recruitment efforts for a community-based research project-entitled the Learning Families Project-conducted in Hong Kong. Methods: In collaboration with community stakeholders, residents from a public housing estate were recruited to participate in family programs aimed at enhancing family well-being. Various recruitment strategies were employed including the distribution of 19,200 leaflets, 688 posters, a banner, a kick-off ceremony, 10 promotion activities, 1,000 direct calls, word of mouth, 51 mobile counters, and 10 door-to-door visits...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29449788/rrs1-gene-expression-involved-in-the-progression-of-papillary-thyroid-carcinoma
#9
Feng Chen, Yaqiong Jin, Lin Feng, Jie Zhang, Jun Tai, Jin Shi, Yongbo Yu, Jie Lu, Shengcai Wang, Xin Li, Ping Chu, Shujing Han, Shujun Cheng, Yongli Guo, Xin Ni
Background: Papillary thyroid carcinoma (PTC) is one of the most frequent malignancies of the endocrine system, whose mechanisms of pathogenesis, progression and prognosis are still far from being clearly elucidated. Despite an increasing body of evidences highlights ribosome biogenesis regulator homolog (RRS1) as a ribosome biogenesis protein in yeast and plants, little is known about human RRS1 function. Methods: Proliferation, cell cycle and apoptosis of PTC cells were assessed following the knockdown of RRS1 expression though MTT, colony formation assay, and flow cytometry...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29449590/lateral-force-microscopy-of-interfacial-nanobubbles-friction-reduction-and-novel-frictional-behavior
#10
Chih-Wen Yang, Kwan-Tai Leung, Ren-Feng Ding, Hsien-Chen Ko, Yi-Hsien Lu, Chung-Kai Fang, Ing-Shouh Hwang
Atomic force microscopy is used to conduct single-asperity friction measurements at a water-graphite interface. Local mapping of the frictional force, which is based on the degree of the cantilever twisting, shows nearly friction-free when a tip scans over a nanobubble. Surprisingly, apart from being gapless, the associated friction loop exhibits a tilt in the cantilever twisting versus the tip's lateral displacement with the slope depending on the loading force. The sign of the slope reverses at around zero loading force...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29448722/characterization-of-pulse-reverses-electroforming-on-hard-gold-coating
#11
Young-Min Byoun, Young-Tai Noh, Young-Geun Kim, Seung-Hwan Ma, Gwan-Hoon Kim
Effect of pulse reverse current (PRC) method on brass coatings electroplated from gold solution was investigated by various plating parameters such as plating duration, the anodic duty cycle, the anodic current density and the cathodic current density. The reversed current results in a significant change in the morphology of electrodeposits, improvement of the overall current efficiency and reduction of deposit porosity. With longer pulses, hemispherical surface features are generated, while larger grains result from shorter pulse widths...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448550/effect-of-the-manganese-phosphate-solution-with-additive-agent-of-tartaric-acid
#12
Young-Tai Noh, Young-Min Byoun, Jong-Kyu Park, Sun-Kyo Seo, Soong-Keun Hyun, Chi-Hwan Lee
In this study, the correlation between morphology and friction of manganese phosphate coating layer with additive agent of tartaric acid by 2, 4, 6 g were investigated. The microstructure and morphology of the coatings were studied by scanning electron microscopy (SEM), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDS) and atomic force microscopic (AFM). Potentiodynamic polarization test was carried out in order to evaluate the corrosion protection properties of manganese phosphate coating in 3...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448289/lessons-from-pathological-analysis-of-recurrent-early-esophageal-squamous-cell-neoplasia-after-complete-endoscopic-radiofrequency-ablation
#13
Wen-Lun Wang, I-Wei Chang, Chien-Chuan Chen, Chi-Yang Chang, Cheng-Hao Tseng, Chi-Ming Tai, Jaw-Town Lin, Hsiu-Po Wang, Ching-Tai Lee
BACKGROUND: Endoscopic radiofrequency ablation (RFA) is a treatment option for early esophageal squamous cell neoplasia (ESCN); however, long-term follow-up studies are lacking. The risks of local recurrence and "buried cancer" are also uncertain. METHODS: Patients with flat-type ESCN who were treated with balloon-type ± focal-type RFA were consecutively enrolled. Follow-up endoscopy was performed at 1, 3, and 6 months, and then every 6 months thereafter...
February 15, 2018: Endoscopy
https://www.readbyqxmd.com/read/29447237/pathophysiological-and-neurobehavioral-characteristics-of-a-propionic-acid-mediated-autism-like-rat-model
#14
Jeonghyun Choi, Seunghoon Lee, Jinyoung Won, Yunho Jin, Yunkyung Hong, Tai-Young Hur, Joo-Heon Kim, Sang-Rae Lee, Yonggeun Hong
Autism spectrum disorder (ASD) is induced by complex hereditary and environmental factors. However, the mechanisms of ASD development are poorly understood. The purpose of this study was to identify standard indicators of this condition by comparing clinical, pathophysiological, and neurobehavioral features in an autism-like animal model. A total of 22 male Sprague-Dawley rats were randomly divided into control and 500 mg/kg propionic acid (PPA)-treated groups. Rats were subjected to behavioral tests, gene expression analyses, and histological analyses to detect pathophysiological and neurobehavioral alterations...
2018: PloS One
https://www.readbyqxmd.com/read/29447134/histone-deacetylase-5-hdac5-regulates-neuropathic-pain-through-sry-related-hmg-box-10-sox10-dependent-mechanism-in-mice
#15
Pan Gu, Zhiqiang Pan, Xiao-Min Wang, Liting Sun, Lydia Wai Tai, Chi Wai Cheung
A strong link between histone deacetylases (HDACs) and nociceptive hypersensitivity has been indicated in different pain models. However, the underlying molecular and cellular mechanisms remain elusive. Here, we discovered that partial sciatic nerve ligation-induced mechanical allodynia and thermal hyperalgesia in mice were associated with increased mRNA and protein expressions of HDAC5 (a member of class IIa HDACs) and SRY-related HMG-box 10 (SOX10) in the ipsilateral lumbar dorsal horn. Gene knockdown of spinal HDAC5 or SOX10 attenuated partial sciatic nerve ligation-induced nociceptive hypersensitivity, companied with decrease of spinal neuronal sensitization markers, namely phosphorylated-Erk, phosphorylated-GluN1 (ser896), and c-Fos...
March 2018: Pain
https://www.readbyqxmd.com/read/29447014/macrophage-migration-inhibitory-factor-mif-inhibitor-z-590-suppresses-cartilage-destruction-in-adjuvant-induced-arthritis-via-inhibition-of-macrophage-inflammatory-activation
#16
Zhiyu Zhang, Rong Zhang, Linlang Li, Lijun Zhu, Shiyuan Gao, Qiran Lu, Yihui Gu, Yu Zhang, Huicui Yang, Tingjun Hou, Xuechu Zhen, Long Tai Zheng
INTRODUCTION: Macrophage migration inhibitory factor (MIF) is a pleiotropic pro-inflammatory mediator that is involved in the progression of rheumatoid arthritis (RA). Previously, we demonstrated a small molecule compound 3-[(biphenyl-4-ylcarbonyl) carbamothioyl] amino benzoic acid (Z-590) could inhibit MIF activity with docking-based virtual screening and experimental evaluation. MATERIALS AND METHODS: The LPS activated RAW264.7 macrophage cells were used to determine the anti-inflammatory effects of Z-590 in vitro...
February 15, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29444997/efficacy-of-multicomponent-culturally-tailored-hiv-sti-prevention-interventions-targeting-foreign-female-entertainment-workers-a-quasi-experimental-trial
#17
Raymond B T Lim, Olive N Y Cheung, Bee Choo Tai, Mark I-C Chen, Roy K W Chan, Mee Lian Wong
OBJECTIVES: We assessed the efficacy of a multicomponent culturally tailored HIV/STI prevention intervention programme on consistent condom use and STI incidence among foreign Thai and Vietnamese female entertainment workers (FEWs) in Singapore. METHODS: We conducted a quasi-experimental pretest and post-test intervention trial with a comparison group. We recruited 220 participants (115 Vietnamese and 105 Thai) for the comparison group, followed by the intervention group (same number) from the same sites which were purposively selected after a 3-month interval period...
February 14, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29444665/comparison-of-1-year-outcomes-after-ahmed-glaucoma-valve-implantation-with-and-without-ologen-adjuvant
#18
Tai Jun Kim, Sohyun Kang, Jin Wook Jeoung, Young Kook Kim, Ki Ho Park
BACKGROUND: Many studies have investigated the clinical benefits of Ologen for trabeculectomy. However, its benefits for Ahmed glaucoma valve (AGV) implantation have not been investigated as extensively. The aim of this study was to compare the 1-year outcomes of AGV implantation with and without Ologen adjuvant for the treatment of refractory glaucoma. METHODS: This retrospective study included a total of 20 eyes of 20 glaucoma patients, who were followed for at least 1-year after undergoing AGV implantation...
February 14, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29444439/differential-effector-engagement-by-oncogenic-kras
#19
Tina L Yuan, Arnaud Amzallag, Rachel Bagni, Ming Yi, Shervin Afghani, William Burgan, Nicole Fer, Leslie A Strathern, Katie Powell, Brian Smith, Andrew M Waters, David Drubin, Ty Thomson, Rosy Liao, Patricia Greninger, Giovanna T Stein, Ellen Murchie, Eliane Cortez, Regina K Egan, Lauren Procter, Matthew Bess, Kwong Tai Cheng, Chih-Shia Lee, Liam Changwoo Lee, Christof Fellmann, Robert Stephens, Ji Luo, Scott W Lowe, Cyril H Benes, Frank McCormick
KRAS can bind numerous effector proteins, which activate different downstream signaling events. The best known are RAF, phosphatidylinositide (PI)-3' kinase, and RalGDS families, but many additional direct and indirect effectors have been reported. We have assessed how these effectors contribute to several major phenotypes in a quantitative way, using an arrayed combinatorial siRNA screen in which we knocked down 41 KRAS effectors nodes in 92 cell lines. We show that every cell line has a unique combination of effector dependencies, but in spite of this heterogeneity, we were able to identify two major subtypes of KRAS mutant cancers of the lung, pancreas, and large intestine, which reflect different KRAS effector engagement and opportunities for therapeutic intervention...
February 13, 2018: Cell Reports
https://www.readbyqxmd.com/read/29440459/mir-139-5p-inhibits-isoproterenol-induced-cardiac-hypertrophy-by-targeting-c-jun
#20
Su Ming, Wang Shui-Yun, Qiu Wei, Li Jian-Hui, Hui Ru-Tai, Song Lei, Jia Mei, Wang Hui, Wang Ji-Zheng
Hypertrophic cardiomyopathy (HCM) is a serious monogenic disease characterized by cardiac hypertrophy, fibrosis, sudden cardiac death and heart failure. Previously, we identified that miR-139-5p was downregulated in HCM patients. However, the regulatory effects of miR-139-5p remain unclear. Thus, we investigated the role of miR-139-5p in the regulation of cardiac hypertrophy. The expression of miR-139-5p in left ventricular tissues in HCM patients and mice subjected to transverse aortic constriction (TAC) was significantly downregulated...
February 12, 2018: Bioscience Reports
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