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https://www.readbyqxmd.com/read/29349669/positive-correlation-between-matrix-metalloproteinases-and-epithelial-to-mesenchymal-transition-and-its-association-with-clinical-outcome-in-bladder-cancer-patients
#1
R Singh, A Mandhani, V Agrawal, Minal Garg
Involvement of matrix metalloproteinases (MMPs) in the pathogenesis of urothelial carcinoma elects them to be sensitive marker for clinical and prognostic implications. MMPs regulate tumor growth and invasion by inducing epithelial-to-mesenchymal transition (EMT) which is characterized by the complex reprogramming of epithelial cells and ultimately bring about major changes in the structural organization of bladder urothelium. The present study has been undertaken to evaluate the clinical relevance of MMPs in two distinct types of bladder cancer disease...
January 18, 2018: Cancer Microenvironment: Official Journal of the International Cancer Microenvironment Society
https://www.readbyqxmd.com/read/29349048/versatility-of-modified-nasolabial-flap-in-oral-and-maxillofacial-surgery
#2
Geeti Vajdi Mitra, Sarwpriya Sharma Bajaj, Sushmitha Rajmohan, Tejas Motiwale
Background: To evaluate the versatility and reach of modified nasolabial flap used in reconstruction of defects created in and around the oral cavity. Methods: A total number of 20 cases were selected. Out of which 13 were males and 7 females. The age of these patients ranged from 24-63 years. 29 modified nasolabial flaps were raised in twenty patients. Based on clinical and histopathological examination, out of 20 patients, 14 patients were diagnosed with oral submucous fibrosis, 3 with verrucous carcinoma, 1 with squamous papilloma, 1 with oro-antral fistula and 1 with traumatic loss of lower lip...
December 2017: Archives of Craniofacial Surgery
https://www.readbyqxmd.com/read/29348532/amygdala-orbitofrontal-structural-and-functional-connectivity-in-females-with-anxiety-disorders-with-and-without-a-history-of-conduct-disorder
#3
Philip Lindner, Pär Flodin, Peter Larm, Meenal Budhiraja, Ivanka Savic-Berglund, Jussi Jokinen, Jari Tiihonen, Sheilagh Hodgins
Conduct disorder (CD) and anxiety disorders (ADs) are often comorbid and both are characterized by hyper-sensitivity to threat, and reduced structural and functional connectivity between the amygdala and orbitofrontal cortex (OFC). Previous studies of CD have not taken account of ADs nor directly compared connectivity in the two disorders. We examined three groups of young women: 23 presenting CD and lifetime AD; 30 presenting lifetime AD and not CD; and 17 with neither disorder (ND). Participants completed clinical assessments and diffusion-weighted and resting-state functional MRI scans...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335346/severity-of-sacroiliitis-and-erythrocyte-sedimentation-rate-are-associated-with-a-low-trabecular-bone-score-in-young-male-patients-with-ankylosing-spondylitis
#4
Kwi Young Kang, Min Kyung Chung, Ha Neul Kim, Yeon Sik Hong, Ji Hyeon Ju, Sung-Hwan Park
OBJECTIVE: To examine factors related to a low trabecular bone score (TBS) and the association between TBS and vertebral fractures in patients with ankylosing spondylitis (AS). METHODS: One hundred patients (all male, aged < 50 yrs) who fulfilled the modified New York criteria for the classification of AS were enrolled. The TBS and bone mineral density (BMD) were assessed using dual-energy X-ray absorptiometry. Clinical variables, inflammatory markers, and the presence of vertebral fractures were also assessed...
January 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29335233/internet-based-group-intervention-for-ovarian-cancer-survivors-feasibility-and-preliminary-results
#5
Ellen M Kinner, Jessica S Armer, Bonnie A McGregor, Jennifer Duffecy, Susan Leighton, Marya E Corden, Janine Gauthier Mullady, Frank J Penedo, Susan K Lutgendorf
BACKGROUND: Development of psychosocial group interventions for ovarian cancer survivors has been limited. Drawing from elements of cognitive-behavioral stress management (CBSM), mindfulness-based stress reduction (MBSR), and acceptance and commitment therapy (ACT), we developed and conducted preliminary testing of an Internet-based group intervention tailored specifically to meet the needs of ovarian cancer survivors. The Internet-based platform facilitated home delivery of the psychosocial intervention to a group of cancer survivors for whom attending face-to-face programs could be difficult given their physical limitations and the small number of ovarian cancer survivors at any one treatment site...
January 15, 2018: JMIR Cancer
https://www.readbyqxmd.com/read/29331282/development-testing-and-implementation-of-a-training-curriculum-for-nonphysician-health-workers-to-reduce-cardiovascular-disease
#6
Maheer Khan, Pablo Lamelas, Hadi Musa, Jared Paty, Tara McCready, Robby Nieuwlaat, Eleonor Ng, Patricio Lopez-Jaramillo, Jose Lopez-Lopez, Khalid Yusoff, Fadhlina A Majid, Kien Keat Ng, Len Garis, Oyere Onuma, Salim Yusuf, Jon-David Schwalm
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death worldwide. The need to address CVD is greatest in low- and middle-income countries where there is a shortage of trained health workers in CVD detection, prevention, and control. OBJECTIVES: Based on the growing evidence that many elements of chronic disease management can be shifted to nonphysician health care workers (NPHW), the HOPE-4 (Heart Outcomes Prevention and Evaluation Program) aimed to develop, test, and implement a training curriculum on CVD prevention and control in Colombia, Malaysia, and low-resource settings in Canada...
January 10, 2018: Global Heart
https://www.readbyqxmd.com/read/29327945/the-gas-bubble-sign-a-reliable-indicator-of-laryngeal-fractures-in-hanging-on-postmortem-computed-tomography
#7
Katja Schulze, Lars Christian Ebert, Thomas Daniel Ruder, Barbara Fliss, Sebastian Alexander Poschmann, Dominic Gascho, Michael Josef Thali, Patricia Mildred Flach
OBJECTIVE: The purpose was to evaluate the presence of gas in the tissue adjacent to the laryngeal structures, "the gas bubble sign", in cases of hanging as a diagnostic indicator of neck trauma. METHODS: In this study, postmortem computed tomography scans and autopsies of 35 victims of hanging were examined to reveal age-dependent changes, laryngeal fracture, fracture location, and the presence of gas. A matched group with cardiac arrest or intoxication was used as controls (n = 35)...
January 12, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29324756/associations-of-plasma-clusterin-and-alzheimer-s-disease-related-mri-markers-in-adults-at-mid-life-the-cardia-brain-mri-sub-study
#8
Thaddeus Haight, R Nick Bryan, Osorio Meirelles, Russell Tracy, Myriam Fornage, Melissa Richard, Ilya Nasrallah, Kristine Yaffe, David R Jacobs, Cora Lewis, Pamela Schreiner, Stephen Sidney, Christos Davatzikos, Lenore J Launer
BACKGROUND: Clinical and epidemiological studies of older persons have implicated clusterin in Alzheimer's disease (AD) pathogenesis. In the context of identifying early biomarkers of risk, we examined associations of plasma clusterin and characteristics of AD in middle-aged individuals from the community. MATERIALS AND METHODS: Subjects were 639 cognitively normal individuals (mean age 50 ± 3.5) from the Coronary Artery Risk Development in Young Adults (CARDIA) Brain MRI sub-study...
2018: PloS One
https://www.readbyqxmd.com/read/29319373/clinical-learning-spaces-crucibles-for-practice-development-in-physiotherapy-clinical-education
#9
Narelle Patton, Joy Higgs, Megan Smith
This paper, through a deep examination of clinical workplaces as learning spaces, uses a holistic interpretation of clinical education and offers a practice development crucible metaphor as a useful way to deepen how clinical education can be conceptualized. An in-depth conceptualization of clinical education is needed if educators are able to develop wise educational practice and optimize the time students spend in clinical learning settings. The research reported here was undertaken in the qualitative paradigm guided by philosophical hermeneutics...
January 10, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29319204/observation-of-curative-effect-of-intravitreal-injection-of-conbercept-in-wet-age-related-macular-degeneration-optical-coherence-tomography-analysis-after-injection
#10
Wen Yang, Ying Tan, Chaowei Li, Yi Liu, Guohua Lu
To observe the clinical efficacy of intravitreal injection of conbercept in the treatment of wet age-related macular degeneration (wAMD), optical coherence tomography (OCT) and the best corrected visual acuity (BCVA) was observed to measure the changes of anatomical changes of central macular thickness (CMT) and the area and volume of retinal pigment epithelium (RPE) uplift. Fifteen patients (15 eyes) with wet AMD were enrolled in this study. All patients underwent intravitreal injection of conbercept of 0...
January 10, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29318379/osteoinduction-and-conduction-through-absorbable-bone-substitute-materials-based-on-calcium-sulfate-in-vivo-biological-behavior-in-a-rabbit-model
#11
D Pförringer, N Harrasser, H Mühlhofer, M Kiokekli, A Stemberger, M van Griensven, M Lucke, R Burgkart, A Obermeier
Calcium sulfate (CS) can be used as an antibiotically impregnated bone substitute in a variety of clinical constellations. Antibiotically loaded bone substitutes find specific application in orthopedic and trauma surgery to prevent or treat bone infections especially in relation to open bone defects. However, its use as a structural bone graft reveals some concerns due to its fast biodegradation. The addition of calcium carbonate and tripalmitin makes CS formulations more resistant to resorption leaving bone time to form during a prolonged degradation process...
January 9, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29317415/examining-changes-in-the-equity-of-physician-distribution-in-japan-a-specialty-specific-longitudinal-study
#12
Koji Hara, Susumu Kunisawa, Noriko Sasaki, Yuichi Imanaka
OBJECTIVES: In this longitudinal study, we examined changes in the geographical distribution of physicians in Japan from 2000 to 2014 by clinical specialty with adjustments for healthcare demand based on population structure. METHODS: The Japanese population was adjusted for healthcare demand using health expenditure per capita stratified by age and sex. The numbers of physicians per 100 000 demand-adjusted population (DAP) in 2000 and 2014 were calculated for subprefectural regions known as secondary medical areas...
January 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29317079/biotensegrity-and-myofascial-chains-a-global-approach-to-an-integrated-kinetic-chain
#13
S L Dischiavi, A A Wright, E J Hegedus, C M Bleakley
Human movement is a complex orchestration of events involving many different body systems. Understanding how these systems interact during musculoskeletal movements can directly inform a variety of research fields including: injury etiology, injury prevention and therapeutic exercise prescription. Traditionally scientists have examined human movement through a reductionist lens whereby movements are broken down and observed in isolation. The process of reductionism fails to capture the interconnected complexities and the dynamic interactions found within complex systems such as human movement...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29313089/first-delivery-and-ovariectomy-affect-biomechanical-and-structural-properties-of-the-vagina-in-the-ovine-model
#14
Iva Urbankova, Geertje Callewaert, Silvia Blacher, Dries Deprest, Lucie Hympanova, Andrew Feola, Laurent De Landsheere, Jan Deprest
INTRODUCTION AND HYPOTHESIS: Animal models are useful for investigating the genesis of pelvic floor dysfunction and for developing novel therapies for its treatment. There is a need for an alternative large-animal model to the nonhuman primate. Therefore we studied the effects of the first vaginal delivery, ovariectomy and systemic hormonal replacement therapy (HRT) on the biomechanical and structural properties of the ovine vagina. METHODS: We examined the gross anatomical properties of nulliparous, primiparous, ovariectomized multiparous, and ovariectomized hormone-replaced multiparous sheep (six animals per group)...
January 8, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29312828/profiling-of-subgingival-plaque-biofilm-microbiota-in-female-adult-patients-with-clear-aligners-a-three-month-prospective-study
#15
Runzhi Guo, Yunfei Zheng, Hao Liu, Xiaobei Li, Lingfei Jia, Weiran Li
Background: Clear aligners are well known for facilitating oral hygiene maintenance and decreasing susceptibility to periodontal diseases as compared to conventional fixed appliances. However, few research studies focus on the subgingival microbial community during clear aligner treatment (CAT). Hence, this study investigates changes of the subgingival microbial community and its association with clinical characteristics during the first three months of CAT. Methods: Ten female patients with clear aligners were enrolled in this study...
2018: PeerJ
https://www.readbyqxmd.com/read/29310881/comparison-between-masticatory-index-and-mixing-index-among-complete-denture-wearers-and-associated-factors-a-multivariate-analysis
#16
Hala A Elmoula, Nadia Khalifa, Mohammed Nasser Alhajj
STATEMENT OF PROBLEM: Masticatory performance is an important and complex multifactorial process in clinical practice. An exploration of the relationships and effects of the associated factors is lacking. PURPOSE: This clinical survey compared masticatory efficiency (mixing index) with perceived masticatory ability (masticatory index) among complete denture wearers and sought to clarify the relationship between these indices and other factors. MATERIALS AND METHODS: The study consisted of 58 complete denture wearers (37 men, 21 women) ranging between 37 and 80 years of age...
January 5, 2018: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29310640/the-coaching-on-lifestyle-cool-intervention-for-obesity-a-study-protocol-for-an-action-oriented-mixed-methods-study
#17
Celeste E van Rinsum, Sanne M P L Gerards, Geert M Rutten, Ien A M van de Goor, Stef P J Kremers
BACKGROUND: Combined lifestyle interventions (CLIs) have proved to be effective in changing and maintaining behavioural lifestyle changes and reducing overweight and obesity, in clinical and real-world settings. In this CLI, lifestyle coaches are expected to promote lifestyle changes of participants regarding physical activity and diet. In the Coaching on Lifestyle (CooL) intervention, which takes a period of 8 to 10 months, lifestyle coaches counsel adults and children aged 4 years and older (and their parents) who are obese or are overweight with an increased risk of developing cardiovascular diseases or type II diabetes...
January 8, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29306387/attitudes-and-perceptions-of-radiographers-applying-lead-pb-protection-in-general-radiography-an-ethnographic-study
#18
C M Hayre, S Blackman, K Carlton, A Eyden
INTRODUCTION: Since the discovery of X-rays by Rontgen in 1895, lead (Pb) has been used to limit ionising radiation for both operators and patients due to its high density and high atomic number (Z = 82). This study explores the attitudes and perceptions of diagnostic radiographers applying Pb protection during general radiographic examinations, an area underexplored within a contemporary radiographic environment(s). METHODS: This paper presents findings from a wider ethnographic study undertaken in the United Kingdom (UK)...
February 2018: Radiography
https://www.readbyqxmd.com/read/29305655/chrfam7a-gene-expression-in-schizophrenia-clinical-correlates-and-the-effect-of-antipsychotic-treatment
#19
Sunil V Kalmady, Rimjhim Agrawal, Deepthi Venugopal, Venkataram Shivakumar, Anekal C Amaresha, Sri Mahavir Agarwal, Manjula Subbanna, Ashwini Rajasekaran, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramanian
Earlier studies have implicated CHRNA7, coding α-7 nicotinic acetylcholine receptor (α7 nAChR), and its partially duplicated chimeric gene CHRFAM7A in schizophrenia. However, the relationship between the alterations in peripheral gene expression of CHRFAM7A and severity of clinical symptoms has not been examined. Furthermore, potential influence of the antipsychotic medication on CHRFAM7A expression in drug-naive or drug-free schizophrenia is an unexplored area. CHRFAM7A gene expression in lymphocytes was analyzed in 90 antipsychotic-naïve or free schizophrenia patients using TaqMan-based quantitative RT-PCR...
January 5, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29302462/valve-sparing-aortic-root-replacement-midterm-outcomes-and-quality-of-life
#20
Abdel-Kémal Bori Bata, Nicolas D'Ostrevy, Bruno Pereira, Etienne Geoffroy, Nicolas Dauphin, Vedat Eljezi, Kasra Azarnoush, Lucie Ulman, Lionel Camilleri
Background: This study evaluated the midterm outcomes, the valve related events and quality of life of patients treated by valve-sparing aortic root replacement (VSRR). Methods: From January 2003 to December 2014, 88 consecutive patients diagnosed with an aortic root aneurysm or ascending aortic aneurysms underwent VSRR surgery. The mean age was 55±14 (range 19-77) years. A total of 84% of the patients were male; 89% were in New York Heart Association functional class I or II, 55% had aortic regurgitation (AR) grade III or IV...
December 2017: Cardiovascular Diagnosis and Therapy
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