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https://www.readbyqxmd.com/read/29773148/personalized-treatment-outcomes-in-patients-with-somatoform-disorder-a-concept-mapping-study
#1
Sonja Klemm, Saskia van Broeckhuysen-Kloth, Sanne van Vliet, Lummy Oosterhuis, Rinie Geenen
OBJECTIVE: From a patient-centered perspective, treatment outcome measures in somatoform disorder need to be (1) personalized to the patient, (2) fit core problems that are targeted in therapy, and (3) reflect one's ability to adapt and self-manage anticipated deterioration. The aim of this study was to identify an encompassing set of treatment outcome variables in patients with somatoform disorder. METHODS: In-depth interviews yielded a comprehensive overview of 60 treatment outcomes that were sorted in a card sorting task according to similarity of meaning by 30 patients...
June 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29771814/using-technology-to-enhance-teaching-of-patient-centered-interviewing-for-early-medical-students
#2
Stacey Kaltman, Nicholas Talisman, Susan Pennestri, Eleri Syverson, Paige Arthur, Yianna Vovides
INTRODUCTION: Effective strategies for teaching communication skills to health professions students are needed. This article describes the design and evaluation of immersive and interactive video simulations for medical students to practice basic communication skills. METHODS: Three simulations were developed, focusing on patient-centered interviewing techniques such as using open-ended questions, reflections, and empathic responses while assessing a patient's history of present illness...
May 15, 2018: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/29768451/intravitreal-ocriplasmin-for-the-treatment-of-vitreomacular-traction-and-macular-hole-a-study-of-efficacy-and-safety-based-on-nice-guidance
#3
Mahiul M K Muqit, Robin Hamilton, Jason Ho, Sally Tucker, Helen Buck
PURPOSE: To evaluate the real world clinical outcomes of intravitreal ocriplasmin in patients with vitreomacular traction (VMT) with and without full thickness macular holes (FTMH) treated according to NICE guidance. METHODS: Retrospective observational case series of 25 patients treated with a single intravitreal ocriplasmin injection between December 2013 and December 2015. Best corrected visual acuity and optical coherence tomography exams were performed to determine visual outcomes and anatomical VMT release and FTMH closure over time...
2018: PloS One
https://www.readbyqxmd.com/read/29766278/adenomatous-ductal-proliferation-hyperplasia-in-the-parotid-gland-associated-without-any-other-pathological-lesions-a-report-and-survey-of-the-literatures
#4
Bhoj Raj Adhikari, Michiko Nishimura, Kosuke Takimoto, Fumiya Harada, Aya Onishi, Daichi Hiraki, Durga Paudel, Puja Neopane, Masafumi Utsunomiya, Tetsuro Morikawa, Koki Yoshida, Jun Sato, Mamata Shakya, Eiji Nakayama, Hiroki Nagayasu, Yoshihiro Abiko
Adenomatous ductal proliferation/hyperplasia (ADP/H) is a rare hyperplastic condition of the salivary gland. It is mostly associated with other salivary gland pathologies such as tumors and inflammations, and is incidentally found in tissue sections during histopathological examinations of those diseases. Herein, we report a case of ADP/H in the parotid gland not associated with any other pathological lesions, and present a review of the literature on this condition. A 60-year-old Japanese female complained of swelling on the left side of parotid region...
May 15, 2018: Medical Molecular Morphology
https://www.readbyqxmd.com/read/29764440/psychometric-properties-of-the-korean-version-of-the-medical-outcomes-study-hiv-health-survey-results-from-a-multicenter-survey-in-korea
#5
Eun-Jung Shim, Hyeju Ha, Sun Hee Lee, Nam Joong Kim, Eu Suk Kim, Ji Hwan Bang, Kyoung-Ho Song, Bo Kyung Sohn, Hye Youn Park, Kyung-Lak Son, Heesung Hwang, Kwang-Min Lee, Bong-Jin Hahm
BACKGROUND: Precise assessment of health-related quality of life (HRQOL) with a reliable and valid measure is a prerequisite to the enhancement of HRQOL. This study examined the psychometric properties of the Korean version of the Medical Outcomes Study HIV Health Survey (K-MOS-HIV). METHODS: The reliability and validity of the K-MOS-HIV were examined in a multicenter survey involving 201 outpatients with human immunodeficiency virus (HIV)/ acquired immunodeficiency syndrome (AIDS) from four teaching hospitals throughout Korea...
May 15, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29760665/left-ventricular-trabeculations-decrease-the-wall-shear-stress-and-increase-the-intra-ventricular-pressure-drop-in-cfd-simulations
#6
Federica Sacco, Bruno Paun, Oriol Lehmkuhl, Tinen L Iles, Paul A Iaizzo, Guillaume Houzeaux, Mariano Vázquez, Constantine Butakoff, Jazmin Aguado-Sierra
The aim of the present study is to characterize the hemodynamics of left ventricular (LV) geometries to examine the impact of trabeculae and papillary muscles (PMs) on blood flow using high performance computing (HPC). Five pairs of detailed and smoothed LV endocardium models were reconstructed from high-resolution magnetic resonance images (MRI) of ex-vivo human hearts. The detailed model of one LV pair is characterized only by the PMs and few big trabeculae, to represent state of art level of endocardial detail...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29755373/bidirectional-causal-connectivity-in-the-cortico-limbic-cerebellar-circuit-related-to-structural-alterations-in-first-episode-drug-naive-somatization-disorder
#7
Ranran Li, Feng Liu, Qinji Su, Zhikun Zhang, Jin Zhao, Ying Wang, Renrong Wu, Jingping Zhao, Wenbin Guo
Background: Anatomical and functional deficits in the cortico-limbic-cerebellar circuit are involved in the neurobiology of somatization disorder (SD). The present study was performed to examine causal connectivity of the cortico-limbic-cerebellar circuit related to structural deficits in first-episode, drug-naive patients with SD at rest. Methods: A total of 25 first-episode, drug-naive patients with SD and 28 healthy controls underwent structural and resting-state functional magnetic resonance imaging. Voxel-based morphometry and Granger causality analysis (GCA) were used to analyze the data...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29753614/a-22-year-follow-up-reveals-a-variable-disease-severity-in-early-onset-facioscapulohumeral-dystrophy
#8
Rianne J M Goselink, Caroline R van Kernebeek, Karlien Mul, Richard J L F Lemmers, Silvère M van der Maarel, Oebele F Brouwer, Nicol Voermans, George W Padberg, Corrie E Erasmus, Baziel G M van Engelen
AIM: To assess the long-term natural course of early-onset facioscapulohumeral dystrophy (FSHD), which is important for patient management and trial-readiness, and is currently lacking. METHODS: We had the unique opportunity to evaluate 10 patients with early-onset FSHD after 22 years follow-up. Patients underwent a semi-structured interview, physical examination and additional genotyping. RESULTS: Nine initial study participants (median age 37 years) were included, one patient died shortly after first publication...
May 3, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29752306/-apoe-%C3%AE%C2%B52%C3%AE%C2%B54-genotype-incident-ad-and-mci-cognitive-decline-and-ad-pathology-in-older-adults
#9
Shahram Oveisgharan, Aron S Buchman, Lei Yu, Jose Farfel, Vladimir Hachinski, Chris Gaiteri, Philip L De Jager, Julie A Schneider, David A Bennett
OBJECTIVE: To examine the association of the APOE ε2ε4 genotype with incident Alzheimer disease (AD), mild cognitive impairment (MCI), cognitive decline, and AD pathology in older adults. METHODS: We used data from 2,151 older adults of European ancestry who were free of dementia at baseline and underwent structured annual clinical evaluation in a longitudinal study for incident AD and MCI, and cognitive decline. Postmortem examination in decedents documented pathologic AD and quantified β-amyloid and neurofibrillary tangles...
May 11, 2018: Neurology
https://www.readbyqxmd.com/read/29751366/synthesis-characterization-and-electrochemistry-studies-of-iron-iii-complex-with-curcumin-ligand
#10
Gülüzar Özbolat, Arash Alizadeh Yegani, Abdullah Tuli
Iron overload is a serious clinical condition for humans and is a key target in drug development. The aim of this study was to investigate the coordination of iron(III) ions with curcumin ligand that may be used in the treatment of iron overload. Iron(III) complex of curcumin was synthesized and structurally characterized in its solid and solution state by FT-IR, UV-Vis, elemental analysis, and magnetic susceptibility. Electrochemical behavior of the ligand and the complexes were examined using cyclic voltammetry...
May 11, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29750130/light-sheet-microscopy-for-slide-free-non-destructive-pathology-of-large-clinical-specimens
#11
Adam K Glaser, Nicholas P Reder, Ye Chen, Erin F McCarty, Chengbo Yin, Linpeng Wei, Yu Wang, Lawrence D True, Jonathan T C Liu
For the 1.7 million patients per year in the U.S. who receive a new cancer diagnosis, treatment decisions are largely made after a histopathology exam. Unfortunately, the gold standard of slide-based microscopic pathology suffers from high inter-observer variability and limited prognostic value due to sampling limitations and the inability to visualize tissue structures and molecular targets in their native 3D context. Here, we show that an open-top light-sheet microscope optimized for non-destructive slide-free pathology of clinical specimens enables the rapid imaging of intact tissues at high resolution over large 2D and 3D fields of view, with the same level of detail as traditional pathology...
July 2017: Nature Biomedical Engineering
https://www.readbyqxmd.com/read/29749247/iron-chelating-ligand-for-iron-overload-diseases
#12
G Ozbolat, A Tuli
Iron overloads are a serious clinical condition in the health of humans and are therefore a key target in drug development. In this study, iron(III) complex of 8-hydroxyquinoline-5 sulphonic acid was synthesized and structurally characterized in its solid state and solution state by FT-IR, UV-Vis, elemental analysis, magnetic susceptibility and 1H-NMR. The catalase activities of complex were investigated. It was showed that the complex has the catalase activity. It is suggested that this type of complex may constitute a new and interesting basis for the future search for new and more potential drugs...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29748201/quantitative-assessment-of-normal-fetal-brain-myelination-using-fast-macromolecular-proton-fraction-mapping
#13
V L Yarnykh, I Y Prihod'ko, A A Savelov, A M Korostyshevskaya
BACKGROUND AND PURPOSE: Fast macromolecular proton fraction mapping is a recently emerged MRI method for quantitative myelin imaging. Our aim was to develop a clinically targeted technique for macromolecular proton fraction mapping of the fetal brain and test its capability to characterize normal prenatal myelination. MATERIALS AND METHODS: This prospective study included 41 pregnant women (gestational age range, 18-38 weeks) without abnormal findings on fetal brain MR imaging performed for clinical indications...
May 10, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29747354/-long-term-clinical-observation-on-postoperative-microstructural-change-of-macula-lutea-in-treatment-of-idiopathic-macular-epiretinal-membrane
#14
M F Jiao, J P Liu, X T Chen, X R Li
Objective: To evaluate the relationship between the structure of macular region and prognosis after vitrectomy in idiopathic macular epiretinal membrane patients. Methods: Retrospective case series study. The cases of 74 idiopathic macular epiretinal membrane patients (31 female patients, 43 male patients, aged 68.1±6.9) who received surgery treatment in our hospital during January 2013 and December were collected and analyzed. Ophthalmic routine examination and optical coherence tomography (OCT) have been conducted for all patients prior to operation...
April 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29746411/reduced-choriocapillaris-flow-in-eyes-with-type-3-neovascularization-and-age-related-macular-degeneration
#15
Enrico Borrelli, Eric H Souied, K Bailey Freund, Giuseppe Querques, Alexandra Miere, Orly Gal-Or, Riccardo Sacconi, SriniVas R Sadda, David Sarraf
PURPOSE: To study choriocapillaris (CC) flow in eyes with Type 3 neovascularization (NV) and age-related macular degeneration, using optical coherence tomography angiography analysis. METHODS: In this multicenter, retrospective, observational study, we collected data from 21 patients with unilateral Type 3 NV and age-related macular degeneration, based on clinical examination, structural optical coherence tomography, and fluorescein angiography when available. An additional group of 20 nonneovascular age-related macular degeneration eyes with unilateral Type 1 or Type 2 NV due to age-related macular degeneration was included for comparison...
April 30, 2018: Retina
https://www.readbyqxmd.com/read/29742919/factors-associated-with-the-size-of-the-adhesio-interthalamica-based-on-3-0-t-magnetic-resonance-images
#16
Koichiro Yasaka, Hiroyuki Akai, Akira Kunimatsu, Shigeru Kiryu, Osamu Abe
Background Adhesio interthalamica (AI) is a small structure connecting bilateral thalami. Purpose To evaluate the effects of patient age, sex, and lateral diameter of the third ventricle on the long diameter of the AI using multivariate analyses based on magnetic resonance (MR) images obtained with 3.0-T scanners. Material and Methods This clinical retrospective study included images of 153 patients who underwent MR examination using 3.0-T scanners. The long diameter of the AI and lateral diameter of the third ventricle were measured on images in the mid-sagittal plane and axial plane at the anterior commissure, respectively...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29741750/longitudinal-effects-of-activities-social-environment-and-psychotropic-medication-use-on-behavioral-symptoms-of-individuals-with-alzheimer-s-disease-in-nursing-homes
#17
Ben R Inventor, Carol J Farran, Olimpia Paun, Fawn Cothran, Kumar Rajan, Sandra S Swantek, Judith J McCann
A secondary data analysis of 25,560 minutes of structured clinical observations from a longitudinal study examined the impact of time-varying background factors, social environment, and psychotropic medication use on behavioral symptoms of nursing home residents with Alzheimer's disease (AD). Data were collected at baseline (N = 177), 12 months (N = 138), and 24 months (N = 111). Mixed-effects regression modeling showed that at 24 months: (a) higher cognitive and physical function and having a private bedroom/bathroom had the most positive influence on resident positive behaviors; (b) use of antipsychotic medications and solitary activities had the most negative influence on resident positive behaviors; (c) higher cognitive function significantly decreased negative behaviors; and (d) care-related activities and total number of psychotropic medications significantly increased negative behaviors...
May 8, 2018: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29739777/gp-leadership-in-clinical-commissioning-groups-a-qualitative-multi-case-study-approach-across-england
#18
Martin Marshall, Richard Holti, Jean Hartley, Tatum Matharu, John Storey
BACKGROUND: Clinical commissioning groups (CCGs) were established in England in 2013 to encourage GPs to exert greater influence over the processes of service improvement and redesign in the NHS. Little is known about the extent and the ways in which GPs have assumed these leadership roles. AIM: To explore the nature of clinical leadership of GPs in CCGs, and to examine the enablers and barriers to implementing a policy of clinical leadership in the NHS. DESIGN AND SETTING: A qualitative multi-case study approach in six localities across England...
May 8, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29729173/indscators-of-blood-lipid-profile-acute-phase-reactions-and-uric-acid-in-patients-with-arterial-hypertension-combined-with-connective-tissue-dysplasia
#19
Yevheniya H Zaremba, Nataliya O Rak, Olha V Zaremba, Olena V Zaremba-Fedchyshyn, Marianna M Virna, Liliya O Odnorih
OBJECTIVE: Introduction:Changes in the cardiovascular system can be divided into 2 groups due to the connective tissue dysplasia (CTD) and changes in the circulatory system, caused by pathological processes that arose on the basis of the connective structures failure. One of the risk factors of arterial hypertension (AH) remaining insufficiently studied is collagen pathology - nondifferentiated connective tissue dysplasia (NCTD). The presence of connective tissue in all organs and systems, the common origin of smooth muscles, blood and lymph from mesenchyma leads to dysplastic changes in any organ and system...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29727900/diagnosis-and-treatment-of-infraspinatus-tendon-bursa-ossification-in-a-eurasian-dog
#20
Julia Ungru, Stephan Hungerbühler, Wolfgang Henninger, Petra Klupiec, Julia Bödeker, Anna Langer, Michael Fehr, Oliver Harms
A 4-year-old male Eurasian Dog presented at our veterinary clinic with a history of perpetual forelimb lameness in both thoracic limbs. In the clinical exploration, direct pressure over the infraspinatus tendon of insertion caused pain in both thoracic forelimbs and a firm band-like structure was palpable. No improvement was observed after treatment with rest, non-steroidal anti-inflammatory drugs and an intralesional injection of a long-acting glucocorticoid. Radiographic examination, ultrasonographic exploration and computed tomography were performed, identifying ossified structures lateral to the proximal humerus and an irregular roughened periosteum at the insertion and tendon of the infraspinatus muscle on both sides...
April 2018: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
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