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https://www.readbyqxmd.com/read/30242591/chinese-medicine-for-alzheimer-s-disease-a-meta-analysis-of-randomized-controlled-trials
#1
Hang-Kun Ma, Yue Liu, Bo Li, Ying Zhang, Lin-Juan Sun, Feng-Qin Xu
OBJECTIVE: To evaluate the efficacy of oral Chinese medicine (CM) in comparison with donepezil, a cholinesterase inhibitor (ChEI), for the treatment of Alzheimer's disease (AD). METHODS: Randomized controlled trials (RCTs) have been searched, and the effect of CM compared with donepezil in AD has been investigated. An electronic search of MEDLINE, Excerpta Medica Database (EMBASE), Cochrane Library, Chinese Biological Medicine Database (CBMdisc), and China National Knowledge Infrastructure (CNKI) to identify articles in English and Chinese from the inception of the database until October 18, 2015...
September 22, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/30242293/carotid-body-removal-normalizes-arterial-blood-pressure-and-respiratory-frequency-in-offspring-of-protein-restricted-mothers
#2
Viviane Nogueira, Jose Brito-Alves, Danilo Fontes, Larissa Oliveira, Waldecy Lucca, Yves Tourneur, Almir Wanderley, Glauber S F da Silva, Carol Leandro, João Henrique Costa-Silva
The aim of this study is to evaluate the short-term and long-term effects elicited by carotid body removal (CBR) on ventilatory function and the development of hypertension in the offspring of malnourished rats. Wistar rats were fed a normo-protein (NP, 17% casein) or low-protein (LP, 8% casein) diet during pregnancy and lactation. At 29 days of age, the animals were submitted to CBR or a sham surgery, according to the following groups: NP-cbr, LP-cbr, NP-sham, or LP-sham. In the short-term, at 30 days of age, the respiratory frequency (RF) and immunoreactivity for Fos on the retrotrapezoid nucleus (RTN; brainstem site containing CO2 sensitive neurons) after exposure to CO2 were evaluated...
September 21, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30241929/feasibility-of-new-transthoracic-three-dimensional-echocardiographic-automated-software-for-left-heart-chamber-quantification-in-children
#3
Romain Amadieu, Khaled Hadeed, Marion Jaffro, Clément Karsenty, Miarisoa Ratsimandresy, Yves Dulac, Philippe Acar
BACKGROUND: New three-dimensional echocardiographic automated software (HeartModel) is now available to quantify the left heart chambers. The aims of this study were to assess the feasibility, reproducibility, and analysis time of this technique and its correlation with manual three-dimensional echocardiography (3DE) and cardiac magnetic resonance (CMR) in children. METHODS: Ninety-two children (5-17 years of age) were prospectively included in two separate protocols...
September 18, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/30241666/usefulness-of-estimated-plasma-volume-at-postdischarge-follow-up-to-predict-recurrent-events-in-patients-with-heart-failure
#4
Jessica R Balderston, Keyur B Shah, Sarah C Paciulli, Zachary M Gertz
Hospital readmission for patients admitted with heart failure is a persistent problem. Better identification of patients at high risk of readmission for volume overload could have clinical implications. We evaluated estimated plasma volume (ePV), a marker of congestion, to predict readmission for patients seen early after discharge for heart failure. We identified patients hospitalized with a primary heart failure diagnosis and were then seen in a postdischarge clinic. We assessed clinical factors, ePV (derived from hemoglobin and hematocrit), and B-type natriuretic peptide (BNP)...
August 24, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/30240448/circulating-monocyte-subsets-and-heart-failure-prognosis
#5
Elena Elchinova, Iris Teubel, Santiago Roura, Marco A Fernández, Josep Lupón, Carolina Gálvez-Montón, Marta de Antonio, Pedro Moliner, Mar Domingo, Elisabet Zamora, Julio Núñez, Germán Cediel, Antoni Bayés-Genís
Monocytes are a heterogeneous population of effector cells with key roles in tissue integrity restoration and maintenance. Here, we explore the association of monocyte subsets and prognosis in patients with ambulatory heart failure (HF). Monocyte subsets were classified as classical (CD14++/CD16-), intermediate (CD14++/CD16+), or non-classical (CD14+/CD16++). Percentage distribution and absolute cell count were assessed in each subset, and multivariable Cox regression analyses were performed with all-cause death, HF-related hospitalization, and the composite end-point of both as dependent variables...
2018: PloS One
https://www.readbyqxmd.com/read/30239653/predictors-of-quality-of-life-in-young-adults-with-congenital-heart-disease
#6
Sarah Rometsch, Matthias Greutmann, Beatrice Latal, Ivana Bernaschina, Walter Knirsch, Christina Schaefer, Angela Oxenius, Markus A Landolt
Aims: The aim of this study was to identify medical and psychosocial risk factors for impaired health-related quality of life (HRQoL) and poor psychological adjustment (PA) in young adults with congenital heart disease (CHD). Methods and Results: A group of 188 patients (43% females, ages 18-30 years) with various types of CHD and 139 age-matched healthy controls (57% females) completed questionnaires assessing HRQoL, PA, social support, significant life events in the past year, education level, civil status, and employment status...
September 19, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/30239585/early-vascular-aging-risk-assessment-from-ambulatory-blood-pressure-monitoring-the-early-vascular-aging-ambulatory-score
#7
Christina Antza, Ioannis Doundoulakis, Evagelos Akrivos, Stella Stabouli, Christina Trakatelli, Michael Doumas, Vasilios Kotsis
BACKGROUND: This study compared the diagnostic accuracy of blood pressure (BP) measurement methods, office BP, ambulatory BP monitoring (ABPM), and home BP, in the identification of early vascular aging (EVA) and developed a score to predict the risk of EVA in hypertensive patients. METHODS: Two-hundred eighty-two consecutive subjects (39.7% male) aged 56.8  ±  15.8 years were included. Office and out-of-office BP measurements including ABPM on a usual working day and 7 days home BP monitoring were performed...
July 30, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/30239278/effects-of-mild-hypothermia-on-cardiac-and-neurological-function-in-piglets-under-pathological-and-physiological-stress-conditions
#8
Wei Yuan, Jun-Yuan Wu, Yong-Zhen Zhao, Jie Li, Jie-Bin Li, Zhen-Hua Li, Chun-Sheng Li
To investigate the different effects of mild hypothermia on pathological and physiological stress conditions in piglets, 30 pigs were randomized into four groups: cardiac arrest and mild hypothermia (CA-MH group), cardiac arrest and normothermia (CA-NH group), non-CA-MH (NCA-MH group), and a sham operation. The same hypothermia intervention was implemented in both CA-MH and NCA-MH groups. The CA-NH group did not undergo therapeutic hypothermia after resuscitation. The hemodynamic parameters were recorded. Cerebral metabolism variables and neurotransmitters in the extracellular fluid were collected through microdialysis tubes...
September 21, 2018: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/30238809/arterial-stiffness-during-controlled-ovarian-hyperstimulation-and-early-pregnancy-in-women-exposed-to-assisted-reproduction
#9
Emma von Wowern, Pia Saldeen, Per Olofsson
INTRODUCTION: Female sex hormones have vasorelaxing effects in non-pregnant and pregnant women. We aimed to investigate the effect of controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF), and early pregnancy, on arterial stiffness as assessed by digital pulse wave analysis (DPA), hypothesizing reduced arterial stiffness as an effect of increased estrogen levels. MATERIAL AND METHODS: A total of 68 women undergoing IVF were examined with DPA before conception and during IVF treatment with COH and embryo transfer (ET), and in gestational week seven in 19 women who became pregnant...
September 21, 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/30238692/the-impact-of-sedentarism-on-heart-rate-variability-hrv-at-rest-and-in-response-to-mental-stress-in-young-women
#10
José Robertto Zaffalon Júnior, Ariane Oliveira Viana, Gileno Edu Lameira de Melo, Kátia De Angelis
Sedentarism is one of the main risk factors for the onset of cardiometabolic diseases. Some biomarkers, such as heart rate variability (HRV), have been largely studied and found to be involved in the genesis of the dysfunctions associated with sedentary behavior. However, comparatively few studies have focused on the female sex. The objective of this study was to analyze the hemodynamic, autonomic and quality of life parameters at rest and in response to mental stress of sedentary and physically active young women...
September 2018: Physiological Reports
https://www.readbyqxmd.com/read/30238368/natural-sources-of-extracellular-matrix-for-cardiac-repair
#11
Keith L Spinali, Eric G Schmuck
Tissue engineering and regenerative medicine have adopted the use of extracellular matrix (ECM) as a cell delivery device and bioactive regenerative agent. To this end, many ECMs have been investigated for cardiac tissue engineering and regenerative medicine applications with variable success. Many sources of natural ECMs have been tested for cardiac applications. Typically, natural ECMs have been made from decellularized organs or tissues and processed into either sheets or injectable hydrogels. This chapter will review natural sources of ECM materials that have been tested as therapeutic agents in models of heart failure...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30237979/reliability-of-symmetric-dimethylarginine-in-dogs-with-myxomatous-mitral-valve-disease-as-kidney-biomarker
#12
Alice Savarese, Monica Probo, Chiara Locatelli, Sergio Aurelio Zanzani, Alessia Libera Gazzonis, Melissa Papa, Paola Giuseppina Brambilla
The most common cause of heart failure in the canine population is myxomatous mitral valve disease, sometimes complicated by chronic kidney disease. Many studies have been done on the use of symmetric dimethylarginine as biomarker of renal impairment in dogs affected by chronic kidney disease, few studies have examined his reliability as biomarker in dogs affected by heart diseases. Aim of this study was to evaluate symmetric dimethylarginine in dogs affected by mitral valve disease in order to assess his reliability in heart diseases...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/30237708/instability-of-nocturnal-parasympathetic-nerve-function-in-patients-with-chronic-lung-disease-with-or-without-nocturnal-desaturation
#13
Keisaku Fujimoto, Haruna Yamazaki, Akikazu Uematsu
Objective/background: This study was performed to evaluate the association of nocturnal autonomic nerve (AN) dysfunction, especially parasympathetic nerve (PN) function instability, and nocturnal oxygen desaturation (NOD) in patients with chronic lung diseases (CLD). Patients and methods: Twenty-nine stable CLD patients with irreversible pulmonary dysfunction and mild-to-moderate daytime hypoxemia, 13 CLD patients receiving long-term oxygen therapy (LTOT) with maintained SpO2 >90%, and 17 senior healthy volunteers underwent two-night examinations of nocturnal AN function by pulse rate variability (PRV) instead of heart rate variation using a photoelectrical plethysmograph simultaneously monitoring SpO2 and the presence of sleep disordered breathing at home...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30237702/possible-predictive-role-of-electrical-risk-score-on-transcatheter-aortic-valve-replacement-outcomes-in-older-patients-preliminary-data
#14
Gianfranco Piccirillo, Federica Moscucci, Fabiola Mastropietri, Claudia Di Iorio, Marco Valerio Mariani, Marcella Fabietti, Gaetana M Stricchiola, Ilaria Parrotta, Gennaro Sardella, Massimo Mancone, Damiano Magrì
Objectives: To evaluate the predicative power of the electrical risk score (ERS), a noninvasive and inexpensive test obtained by means of a standard 12-lead electrocardiogram (ECG), in a cohort of elderly patients who had undergone transcatheter aortic valve replacement (TAVR). Methods: Survivors and non-survivors after TAVR at 1-year follow-up were compared in respect to the pre-procedural ERS as well as a number of other clinical and instrumental variables. ERS is composed of seven simple ECG markers: heart rate (>75 bpm); QRS duration (>110 ms); left ventricular hypertrophy (Sokolow-Lyon criteria); delayed QRS transition zone (≥ V4); frontal QRS-T angle (>90°); long QTBazett (>450 ms for men and >460 in women) or JTBazett (330 ms for men and >340 ms for women); and long Tpeak to Tend interval (Tp-e ) (>89 ms)...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/30237597/anaesthesia-for-non-obstetric-surgery-in-obstetric-patients
#15
REVIEW
G L Ravindra, Abhinava S Madamangalam, Shwetha Seetharamaiah
Anaesthesia for pregnant patients presenting for non-obstetric surgery needs a thorough understanding of the physiological changes and altered pharmacokinetics of pregnancy. Considering the effects of surgery and anaesthesia on the foetus, only essential and emergency surgeries are performed during pregnancy. Surgical procedures in second trimester have the advantage of better foetal outcome. The primary concerns of maternal and foetal safety are achieved by a focused multidisciplinary team-based approach with respect to the surgical condition...
September 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/30237411/reproducibility-study-on-myocardial-strain-assessment-using-fast-senc-cardiac-magnetic-resonance-imaging
#16
Sorin Giusca, Grigorios Korosoglou, Victoria Zieschang, Lukas Stoiber, Bernhard Schnackenburg, Christian Stehning, Rolf Gebker, Burkert Pieske, Andreas Schuster, Sören Backhaus, Elisabeth Pieske-Kraigher, Amit Patel, Keigo Kawaji, Henning Steen, Tomas Lapinskas, Sebastian Kelle
Myocardial strain is a well validated parameter for estimating left ventricular (LV) performance. The aim of our study was to evaluate the inter-study as well as intra- and interobserver reproducibility of fast-SENC derived myocardial strain. Eighteen subjects (11 healthy individuals and 7 patients with heart failure) underwent a cardiac MRI examination including fast-SENC acquisition for evaluating left ventricular global longitudinal (GLS) and circumferential strain (GCS) as well as left ventricular ejection fraction (LVEF)...
September 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30237109/cardiac-safety-evaluation-in-cancer-clinical-trials
#17
Dorothy M Gujral, Susan J Cleator, Sanjeev Bhattacharyya
Identification and quantification of the cardiac adverse effects of new cancer therapeutics is important when comparing treatment arms in clinical trials. Heart failure and left ventricular dysfunction are some of the most common adverse cardiac effects of a range of cancer treatments, including anthracyclines, trastuzumab and other targeted agents. Using the example of trastuzumab-induced cardiac dysfunction, we evaluated phase III clinical trials performed over the past decade to establish the methods used to identify heart failure and impairment of left ventricular function...
September 17, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/30236526/associations-between-wellness-and-internal-and-external-load-variables-in-two-intermittent-small-sided-soccer-games
#18
Filipe Manuel Clemente
The purpose of this study was to test the associations between wellness and internal and external load variables during two intermittent small-sided games (SSGs). Ten male amateur soccer players (age: 19.8±1.6 years; experience: 8.3±2.1 years; height: 177.4±3.8 cm; weight: 71.7±4.2 kg) voluntarily participated in this study. The 5 × 5 format was played in 3 × 6 min and 6 × 3 min regimens. Muscle soreness (DOMS), stress, fatigue, and sleep quality were rated before each session. Perceived exertion (RPE); mean heart rate (HRmean); total (TD), jogging (JD), running (RD), and sprinting (SD) distances; player's training load (PTL); and total accelerations (TAc) were monitored during SSGs...
September 17, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/30236236/development-and-internal-validation-of-a-novel-risk-adjustment-model-for-adult-patients-undergoing-emergency-laparotomy-surgery-the-national-emergency-laparotomy-audit-risk-model
#19
N Eugene, C M Oliver, M G Bassett, T E Poulton, A Kuryba, C Johnston, I D Anderson, S R Moonesinghe, M P Grocott, D M Murray, D A Cromwell, K Walker
BACKGROUND: Among patients undergoing emergency laparotomy, 30-day postoperative mortality is around 10-15%. The risk of death among these patients, however, varies greatly because of their clinical characteristics. We developed a risk prediction model for 30-day postoperative mortality to enable better comparison of outcomes between hospitals. METHODS: We analysed data from the National Emergency Laparotomy Audit (NELA) on patients having an emergency laparotomy between December 2013 and November 2015...
October 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/30236234/association-between-preoperative-ambulatory-heart-rate-and-postoperative-myocardial-injury-a-retrospective-cohort-study
#20
K S Ladha, W S Beattie, G Tait, D N Wijeysundera
BACKGROUND: Resting heart rate is well established as a predictor of morbidity and mortality in the general population. However, the relationship between preoperative heart rate and perioperative outcomes, specifically myocardial injury, is unclear. METHODS: This retrospective cohort study included patients undergoing elective major non-cardiac surgery from 2008 to 2014 at a multisite healthcare system. The exposure was ambulatory heart rate measured during the outpatient preoperative clinic visit, whereas the outcome of interest was myocardial injury (peak postoperative troponin I concentration >30 ng L-1 )...
October 2018: British Journal of Anaesthesia
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