Angelo Lu, Hanna G Zimmermann, Svenja Specovius, Seyedamirhosein Motamedi, Claudia Chien, Charlotte Bereuter, Marco A Lana-Peixoto, Mariana Andrade Fontenelle, Fereshteh Ashtari, Rahele Kafieh, Alireza Dehghani, Mohsen Pourazizi, Lekha Pandit, Anitha D'Cunha, Ho Jin Kim, Jae-Won Hyun, Su-Kyung Jung, Letizia Leocani, Marco Pisa, Marta Radaelli, Sasitorn Siritho, Eugene F May, Caryl Tongco, Jérôme De Sèze, Thomas Senger, Jacqueline Palace, Adriana Roca-Fernández, Maria Isabel Leite, Srilakshmi M Sharma, Hadas Stiebel-Kalish, Nasrin Asgari, Kerstin Kathrine Soelberg, Elena H Martinez-Lapiscina, Joachim Havla, Yang Mao-Draayer, Zoe Rimler, Allyson Reid, Romain Marignier, Alvaro Cobo-Calvo, Ayse Altintas, Uygur Tanriverdi, Rengin Yildirim, Orhan Aktas, Marius Ringelstein, Philipp Albrecht, Ivan Maynart Tavares, Denis Bernardi Bichuetti, Anu Jacob, Saif Huda, Ibis Soto de Castillo, Axel Petzold, Ari J Green, Michael R Yeaman, Terry J Smith, Lawrence Cook, Friedemann Paul, Alexander U Brandt, Frederike Cosima Oertel
BACKGROUND: Patients with anti-aquaporin-4 antibody seropositive (AQP4-IgG+) neuromyelitis optica spectrum disorders (NMOSDs) frequently suffer from optic neuritis (ON) leading to severe retinal neuroaxonal damage. Further, the relationship of this retinal damage to a primary astrocytopathy in NMOSD is uncertain. Primary astrocytopathy has been suggested to cause ON-independent retinal damage and contribute to changes particularly in the outer plexiform layer (OPL) and outer nuclear layer (ONL), as reported in some earlier studies...
February 2022: Journal of Neurology, Neurosurgery, and Psychiatry