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https://www.readbyqxmd.com/read/29228514/gait-speed-predicts-post-operative-medical-complications-in-elderly-gastric-cancer-patients-undergoing-gastrectomy
#1
Arvine Chandoo, Chu-Huai Chi, Weiping Ji, Yingpeng Huang, Xiao-Dong Chen, Wei-Teng Zhang, Rui-Sen Wu, Xian Shen
BACKGROUND: Gait speed is a clinical outcome that can measure the physical performance of elderly gastric patients. The purpose of this study was to determine the importance of gait speed in predicting post-operative morbidities in elderly patients undergoing curative gastrectomy. METHODS: We conducted a prospective study of 357 elderly patients (≥65 years old) undergoing curative gastrectomy. Preoperative gait speed was measured in a 6-m well-lit and unobstructed hallway...
December 11, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29228466/concomitant-organ-resection-does-not-improve-outcomes-in-primary-retroperitoneal-well-differentiated-liposarcoma-a-retrospective-cohort-study-at-a-major-sarcoma-center
#2
Naruhiko Ikoma, Christina L Roland, Keila E Torres, Yi-Ju Chiang, Wei-Lien Wang, Neeta Somaiah, Gary N Mann, Kelly K Hunt, Janice N Cormier, Barry W Feig
BACKGROUND: We investigated whether concomitant organ removal as part of the primary resection of RP WDLPS confers an outcome advantage in patients treated at a major sarcoma center. METHODS: The departmental sarcoma database was reviewed to identify patients with RP WDLPS who underwent initial surgical resection for primary disease at MD Anderson Cancer Center during the study period 1995-2011. We retrospectively reviewed medical records and examined associations between clinicopathologic variables and overall survival (OS) as well as disease-free survival (DFS)...
December 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29228101/spironolactone-and-resistant-hypertension-in-heart-failure-with-preserved-ejection-fraction
#3
P Rossignol, B Claggett, J Liu, O Vardeny, B Pitt, F Zannad, S Solomon
Background: Recent evidence suggests that the mineralocorticoid receptor antagonist spironolactone should be the preferred fourth line antihypertensive treatment in resistant hypertension (RHTN). Whether spironolactone improves blood pressure (BP) control in heart failure with preserved ejection fraction (HFpEF) and RHTN is unknown. Methods: We identified patients with RHTN, defined as baseline systolic blood pressure (SBP) between 140 and 160 mmHg on 3 or more medications, in the Americas cohort of the TOPCAT trial, in which patients with HFpEF were randomized to spironolactone vs...
December 7, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29228089/prophylactic-preprocedure-platelet-transfusion-is-associated-with-increased-risk-of-thrombosis-and-mortality
#4
Amy E Schmidt, Kelly F Henrichs, Scott A Kirkley, Majed A Refaai, Neil Blumberg
Objectives: We evaluated thrombosis and mortality rates of hospitalized patients receiving prophylactic platelet transfusion prior to an invasive procedure. Methods: Patient age and underlying medical condition(s), preprocedure and postprocedure platelet counts, type of procedure, number of platelet products transfused, and any complications were recorded on every prophylactic platelet given prior to an invasive procedure. Results: A total of 376 prophylactic transfusion recipients were identified...
December 7, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29228071/associations-between-tau-%C3%AE-amyloid-and-cognition-in-parkinson-disease
#5
Joseph R Winer, Anne Maass, Peter Pressman, Jordan Stiver, Daniel R Schonhaut, Suzanne L Baker, Joel Kramer, Gil D Rabinovici, William J Jagust
Importance: Multiple disease processes are associated with cognitive impairment in Parkinson disease (PD), including Lewy bodies, cerebrovascular disease, and Alzheimer disease. It remains unknown whether tau pathology relates to cognition in patients with PD without dementia. Objective: To compare tau aggregation in patients with PD who are cognitively normal (PD-CN), patients with PD with mild cognitive impairment (PD-MCI), and healthy control participants, and evaluate the relationships between β-amyloid (Aβ), tau, and cognition in patients with PD who did not have dementia...
December 11, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29228042/risk-of-thromboembolism-in-cisplatin-versus-carboplatin-treated-patients-with-lung-cancer
#6
Eric S Kim, Andrea M Baran, Esther L Mondo, Thomas D Rodgers, Gradon C Nielsen, David W Dougherty, Kishan J Pandya, David Q Rich, Edwin van Wijngaarden
INTRODUCTION: Carboplatin is widely used to treat lung cancer in the United States as an alternative to cisplatin. Several studies have demonstrated that cisplatin-based regimen is associated with a high frequency of thromboembolic complications. However, there has been limited investigation directly comparing the risk of thromboembolic events (TEEs) between cisplatin- and carboplatin-treated patients with lung cancer. METHODS: All lung cancer patients treated with cisplatin or carboplatin at Wilmot Cancer Center, University of Rochester between 2011 and 2014 were included...
2017: PloS One
https://www.readbyqxmd.com/read/29227883/associations-between-medical-cannabis-and-other-drug-use-among-unstably-housed-women
#7
Meredith C Meacham, Danielle E Ramo, Alex H Kral, Elise D Riley
BACKGROUND: Several studies suggest that U.S. state-level legalization of cannabis for medical purposes may be associated with reductions in opioid use; yet its relationship with stimulant use, particularly in high-risk populations like unstably housed women, has received less attention. The purpose of this study was to estimate independent associations between medical and non-medical use of cannabis and use of stimulants and opioids among unstably housed women. METHODS: Cross-sectional data were analyzed from 245 women in the SHADOW study, a community based cohort in San Francisco, CA, in which HIV+ women were oversampled (126 HIV+ and 119 HIV-)...
December 8, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29227855/a-case-report-of-successful-management-of-clostridium-difficile-colitis-with-antegrade-fidaxomicin-through-a-mucous-fistula-obviating-the-need-for-subtotal-colectomy
#8
Suzanne Arnott, Matthew Skancke, Sheena Chen, Bruce Abell
INTRODUCTION: Clostridium difficile is the most common cause of healthcare-associated infections and can have devastating morbidity and mortality. Traditional treatment algorithms involve intravenous metronidazole and enteric metronidazole or vancomycin. Fidaxomicin (DificidR) targets "switch regions" within RNA polymerases and effectively kills clostridium difficile bacteria and is typically administered orally primarily or through a naso/oro-gastric conduit. PRESENTATION OF CASE: 55-year-old with a recent elective surgical procedure was hospitalized with multifocal pneumonia and subsequently developed clostridium difficile colitis...
November 27, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29227846/maternal-human-chorionic-gonadotrophin-concentrations-in-very-early-pregnancy-and-risk-of-hyperemesis-gravidarum-a-retrospective-cohort-study-of-4372-pregnancies-after-in-vitro-fertilization
#9
Johanne Dypvik, Andrea Lid Pereira, Tom Gunnar Tanbo, Anne Eskild
OBJECTIVE: We investigated the association of human chorionic gonadotrophin (hCG) concentrations on a fixed day in very early pregnancy with development of hyperemesis gravidarum. STUDY DESIGN: This retrospective cohort study included 3107 singleton and 1265 twin pregnancies after in vitro fertilization treated at Department of Reproductive Medicine, Rikshospitalet, Oslo University Hospital, Norway in the period 1996-2013. Maternal serum hCG concentrations was measured on day 12 after embryo transfer...
December 7, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29227839/medical-marijuana-laws-and-adolescent-use-of-marijuana-and-other-substances-alcohol-cigarettes-prescription-drugs-and-other-illicit-drugs
#10
Magdalena Cerdá, Aaron L Sarvet, Melanie Wall, Tianshu Feng, Katherine M Keyes, Sandro Galea, Deborah S Hasin
BACKGROUND: Historical shifts have taken place in the last twenty years in marijuana policy. The impact of medical marijuana laws (MML) on use of substances other than marijuana is not well understood. We examined the relationship between state MML and use of marijuana, cigarettes, illicit drugs, nonmedical use of prescription opioids, amphetamines, and tranquilizers, as well as binge drinking. METHODS: Pre-post MML difference-in-difference analyses were performed on a nationally representative sample of adolescents in 48 contiguous U...
December 7, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29227721/chinese-guidelines-for-childhood-asthma-2016-major-updates-recommendations-and-key-regional-data
#11
Jianguo Hong, Yixiao Bao, Aihuan Chen, Changchong Li, Li Xiang, Chuanhe Liu, Zhimin Chen, Deyu Zhao, Zhou Fu, Yunxiao Shang
OBJECTIVE: With increased industrialization and urbanization in China, pediatric asthma is becoming more prevalent. Despite a growing body of evidence, there remains a significant unmet need for adequate management of childhood asthma. The Subspecialty Group of Respiratory Diseases of the Society of Pediatrics, the Chinese Medical Association, and the editorial board of the Chinese Journal of Pediatrics have recently updated the "Guidelines for diagnosis and optimal management of asthma in children," first published in 2008...
December 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29227558/rna-sequencing-identifies-gene-regulatory-networks-controlling-extracellular-matrix-synthesis-in-intervertebral-disk-tissues
#12
Scott M Riester, Yang Lin, Wei Wang, Lin Cong, Abdel-Moneim Mohamed Ali, Sun H Peck, Lachlan J Smith, Bradford L Currier, Michelle Clark, Paul Huddleston, William Krauss, Michael J Yaszemski, Mark E Morrey, Matthew P Abdel, Mohamad Bydon, Wenchun Qu, A Noelle Larson, Andre J van Wijnen, Ahmad Nassr
Degenerative disk disease of the spine is a major cause of back pain and disability. Optimization of regenerative medical therapies for degenerative disk disease requires a deep mechanistic understanding of the factors controlling the structural integrity of spinal tissues. In this investigation, we sought to identify candidate regulatory genes controlling extracellular matrix synthesis in spinal tissues. To achieve this goal we performed high throughput next generation RNA sequencing on 39 annulus fibrosus and 21 nucleus pulposus human tissue samples...
December 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29227522/pediatric-pharmaceutical-ingestions
#13
Jennifer A Lowry, Michele Burns, Diane P Calello
Pharmaceutical ingestions comprise an important part of pediatric toxicology. Based on the 2015 Annual Report of the American Association of Poison Control Centers' National Poison Data System, coupled with recent epidemiology articles on the topic of pediatric toxicology, it is apparent that poison prevention education has not been completely successful in decreasing exposures to toxic drugs. From the unintentional ingestion in a toddler due to unsafe storage to the intentional adolescent ingestion for misuse and abuse, pharmaceutical medications continue to cause harm...
December 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/29227521/pediatric-poisonings-the-risk-of-over-the-counter-pharmaceuticals
#14
Elizabeth Quaal Hines
Every week in the United States, 56% of children younger than age 18 years and 82% of adults take at least one medication. Nonprescription medications, including acetaminophen and ibuprofen, are among the most commonly used pharmaceuticals across all age groups. Use of nonprescription medications, traditionally available over-the-counter, has become ubiquitous. Unfortunately, with such abundant use there is an associated risk for therapeutic misuse, intentional misuse, and even abuse. [Pediatr Ann. 2017;46(12):e454-e458...
December 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/29227505/neurobiology-of-sexual-assault-and-osteopathic-considerations-for-trauma-informed-care-and-practice
#15
Kristen M Cuevas, Jane Balbo, Krista Duval, Elizabeth A Beverly
Sexual assault is a traumatic event with potentially devastating lifelong effects on physical and emotional health. Sexual assault is associated with gastrointestinal, neurologic, and reproductive symptoms, as well as obesity, diabetes, and chronic pain. With 1 in 3 women and 1 in 6 men experiencing some form of unwanted sexual violence in their lifetime, sexual assault is a significant public health problem that necessitates attention in the medical community. This review discusses relevant literature on the neurobiologic changes that occur as a consequence of sexual assault, such as how the brain responds during a traumatic experience and the impact of trauma on memory...
December 11, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29227462/psychiatric-disorders-antiretroviral-medication-adherence-and-viremia-in-a-cohort-of-perinatally-hiv-infected-adolescents-and-young-adults
#16
Amelia Bucek, Cheng-Shiun Leu, Stephanie Benson, Patricia Warne, Elaine J Abrams, Katherine S Elkington, Curtis Dolezal, Andrew Wiznia, Claude Ann Mellins
BACKGROUND: Perinatally HIV-infected (PHIV+) adolescents and young adults (AYA) are at risk for sub-optimal antiretroviral therapy (ART) adherence, and mental health and substance use problems that, in HIV-infected adults, predict non-adherence. Studies on the relationship between psychiatric and substance use disorders (SUD) and adherence among PHIV+ AYA are limited, but may be important to informing evidence-based interventions to promote adherence. METHODS: Data were analyzed from three annual follow-up interviews (FU2-4, N=179) in a longitudinal study of PHIV+ AYA...
December 8, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29227460/neuropathic-like-ocular-pain-and-nonocular-comorbidities-correlate-with-dry-eye-symptoms
#17
Victoria S Chang, Terri P Rose, Carol L Karp, Roy C Levitt, Constantine Sarantopoulos, Anat Galor
OBJECTIVE: To evaluate the association between dry eye (DE) symptoms and neuropathic-like ocular pain (NOP) features, chronic pain conditions, depression, and anxiety in patients presenting for routine ophthalmic examinations. METHODS: Two hundred thirty-three consecutive patients ≥18 years of age presenting to a comprehensive eye clinic between January and August 2016 were included in this study. Information on demographics, chronic pain conditions, medication use, DE symptoms (dry eye questionnaire, DEQ5), NOP complaints (burning; wind, light, and temperature sensitivity), depression, and anxiety indices (patient health questionnaire 9, PHQ-9 and symptom checklist 90-revised, SCL-90-R) were collected for each individual...
December 7, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29227453/effect-of-prophylactic-medication-on-associated-dizziness-and-motion-sickness-in-migraine
#18
Seung-Han Lee, Seong-Hae Jeong, Ji-Soo Kim, Hyo-Jung Kim, Kwang-Dong Choi, Jae-Hwan Choi, Sun-Young Oh, Ji-Yun Park, Dong Uk Kim, Byung-Kun Kim
OBJECTIVE: To determine the efficacy of prophylactic medications for migraine in reducing associated dizziness and motion sickness. STUDY DESIGN: Multicenter prospective observational study. SETTING: Nationwide 9 Dizziness Clinics in South Korea. PATIENTS: One hundred thirty-eight patients who required a preventive medication for migraine accompanied by dizziness and motion sickness. INTERVENTION: At least one of the prophylactic medications was prescribed among the beta-blockers, calcium channel blockers, tricyclic antidepressants, and antiepileptic drugs...
January 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29227452/high-resolution-three-dimensional-delayed-contrast-mri-detects-endolymphatic-hydrops-in-patients-with-vertigo-and-vestibular-schwannoma
#19
Roxana Moayer, Gail P Ishiyama, Stellios Karnezis, Ali R Sepahdari, Akira Ishiyama
OBJECTIVE: Advances in high resolution magnetic resonance imaging (MRI) have enabled the detection of endolymphatic hydrops (EH), a pathological ballooning of the endolymphatic fluid system, known to be associated with Menière's disease. When a patient has a known diagnosis of vestibular schwannoma and develops recurrent episodic vertigo spells, many surgeons recommend surgical intervention, attributing the vestibular symptoms to the vestibular schwannoma. The aim of this study is to evaluate the clinical outcome in patients with vestibular schwannoma and EH, treated medically, for recurrent spells of vertigo...
January 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29227443/associations-between-medicare-part-d-and-out-of-pocket-spending-hiv-viral-load-adherence-and-adap-use-in-dual-eligibles-with-hiv
#20
Nadya Belenky, Brian W Pence, Stephen R Cole, Stacie B Dusetzina, Andrew Edmonds, Jonathan Oberlander, Michael W Plankey, Adebola Adedimeji, Tracey E Wilson, Jennifer Cohen, Mardge H Cohen, Joel E Milam, Elizabeth T Golub, Adaora A Adimora
BACKGROUND: The implementation of Medicare part D on January 1, 2006 required all adults who were dually enrolled in Medicaid and Medicare (dual eligibles) to transition prescription drug coverage from Medicaid to Medicare part D. Changes in payment systems and utilization management along with the loss of Medicaid protections had the potential to disrupt medication access, with uncertain consequences for dual eligibles with human immunodeficiency virus (HIV) who rely on consistent prescription coverage to suppress their HIV viral load (VL)...
January 2018: Medical Care
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