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https://www.readbyqxmd.com/read/28227986/automated-neurovascular-tracing-and-analysis-of-the-knife-edge-scanning-microscope-rat-nissl-data-set-using-a-computing-cluster
#1
Sungjun Lim, Michael R Nowak, Yoonsuck Choe, Sungjun Lim, Michael R Nowak, Yoonsuck Choe, Michael R Nowak, Sungjun Lim, Yoonsuck Choe
We present a novel, parallelizable algorithm capable of automatically reconstructing and calculating anatomical statistics of cerebral vascular networks embedded in large volumes of Rat Nissl-stained data. In this paper, we report the results of our method using Rattus somatosensory cortical data acquired using Knife-Edge Scanning Microscopy. Our algorithm performs the reconstruction task with averaged precision, recall, and F2-score of 0.978, 0.892, and 0.902 respectively. Calculated anatomical statistics show some conformance to values previously reported...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227910/development-of-a-three-dimensional-lattice-free-multiscale-model-of-the-mammary-terminal-end-bud
#2
Joseph D Butner, Vittorio Cristini, Zhihui Wang, Joseph D Butner, Vittorio Cristini, Zhihui Wang, Vittorio Cristini, Joseph D Butner, Zhihui Wang
The terminal end bud (TEB) is a bulbous structure composed of highly proliferative cells that is responsible for mammary gland development during the pubertal stage. This is a highly organized process, involving cellular differentiation hierarchies regulated by endocrine and paracrine signaling. Here, we present development of a lattice-free, three dimensional multiscale agent based model of the TEB to study the effects of cellular phenotypic hierarchies, endocrine and paracrine signaling, and proliferation demographics on pubertal mammary gland development...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227706/skin-mounted-accelerometer-system-for-measuring-knee-range-of-motion
#3
Ryan S McGinnis, Shyamal Patel, Ikaro Silva, Nikhil Mahadevan, Steve DiCristofaro, Elise Jortberg, Melissa Ceruolo, A J Aranyosi, Ryan S McGinnis, Shyamal Patel, Ikaro Silva, Nikhil Mahadevan, Steve DiCristofaro, Elise Jortberg, Melissa Ceruolo, A J Aranyosi, A J Aranyosi, Melissa Ceruolo, Ikaro Silva, Steve DiCristofaro, Elise Jortberg, Ryan S McGinnis, Shyamal Patel, Nikhil Mahadevan
Sufficient range of motion of the knee joint is necessary for performing many activities of daily living. Ambulatory monitoring of knee function can provide valuable information about progression of diseases like knee osteoarthritis and recovery after surgical interventions like total knee arthroplasty. In this paper, we describe a skin-mounted, conformal, accelerometer-based system for measuring knee angle and range of motion that does not require a skilled operator to apply devices. We establish the accuracy of this technique with respect to clinical gold standard goniometric measurements on a dataset collected from normative subjects during the performance of repeated bouts of knee flexion and extension tests...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227674/the-impact-of-different-leaf-limited-accelerations-on-leaf-positional-error-of-a-self-developed-mlc-prototype
#4
Xiang Zhang, Peiqing Ye, Hui Zhang, Xiang Zhang, Peiqing Ye, Hui Zhang, Peiqing Ye, Hui Zhang, Xiang Zhang
Multi-leaf collimator (MLC) provides an available approach to achieve sophisticated radiotherapy techniques and plays an important role in advanced high quality radiation therapy. Delivery accuracy of radiation therapy mainly depends on the leaf sequence generated by treatment plans and dynamic performance of MLCs. Previous studies have explored the influence of various leaf limited velocities and dose rates on the leaf-positional error. However, there is a lack of research on the influence of different leaf limited accelerations on the delivery accuracy or leaf-positional error...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227669/green-lasers-are-beyond-power-limits-mandated-by-safety-standards
#5
M H Lee, K Fox, S Goldwasser, D W M Lau, B Aliahmad, M Sarossy, M H Lee, K Fox, S Goldwasser, D W M Lau, B Aliahmad, M Sarossy, B Aliahmad, M H Lee, K Fox, D W M Lau, M Sarossy, S Goldwasser
There has been an increasing number of reports of people losing vision from laser exposure from pocket laser pointers despite the safety limit of 1 milliwatt (1mW) imposed by the Australian government. We hypothesize that this is because commercially available red and green laser pointers are exceeding their labeled power outputs. We tested the power outputs of 4 red and 4 green lasers which were purchased for less than AUD$30 each. The average of 10 measurements was recorded for each laser. We found that 3 out of 4 red lasers conformed to the 1mW safety standard; in contrast, all of the green lasers exceeded this limit, with one of the lasers recording an output of 127...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227592/saw-lc-coupled-resonator-wideband-vco-for-medical-telemetry
#6
Madhav Venkateswaran, Mark Hillig, James E Brown, Paul J Stadnik, Jeffrey A Von Arx, Brian Sutton, Larry J Stotts, Madhav Venkateswaran, Mark Hillig, James E Brown, Paul J Stadnik, Jeffrey A Von Arx, Brian Sutton, Larry J Stotts, Mark Hillig, Jeffrey A Von Arx, Madhav Venkateswaran, Brian Sutton, James E Brown, Paul J Stadnik, Larry J Stotts
Wireless links with implantable devices can help in real-time monitoring of symptoms, irregularities, implanted device efficacy and their reconfiguration. We present the design of a low-power wideband voltage controlled oscillator (VCO) to facilitate implantable wireless telemetry. A coupled SAW-LC resonator design combines high Q and spectral purity of a SAW element and tunability of an LC-tank. The designed 2.7 MHz bandwidth VCO is suitable for full duplex communication protocols in the MedRadio band with frequency agility and higher duty cycles, in conformance with FCC regulations...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227503/suitability-of-nitinol-electrodes-in-neural-prostheses-such-as-endovascular-neural-interfaces
#7
Yan T Wong, Nicholas L Opie, Sam E John, Giulia Gerboni, Gil S Rind, Stephen M Ronayne, Kate E Fox, Thomas J Oxley, David B Grayden, Yan T Wong, Nicholas L Opie, Sam E John, Giulia Gerboni, Gil S Rind, Stephen M Ronayne, Kate E Fox, Thomas J Oxley, David B Grayden, Sam E John, Stephen M Ronayne, David B Grayden, Nicholas L Opie, Kate E Fox, Giulia Gerboni, Thomas J Oxley, Yan T Wong, Gil S Rind
A major challenge facing neural prostheses is the development of electrodes that are well tolerated by the brain and body. A novel way to circumvent the need to perform an invasive craniotomy and penetration of the blood-brain barrier to implant electrodes, is to guide electrodes up into the cerebral veins and place electrodes on the vessel walls adjacent to neuronal populations. To aid in the development of these stent based devices, microelectrodes manufactured from Nitinol would allow electrodes to be implanted via a catheter and then once deployed, alter their shape to conform to the vessel walls...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227263/an-algorithm-for-rotor-tracking-in-atrial-fibrillation-using-graph-search-based-periodic-peak-detection
#8
Rupin Dalvi, Adrian Suszko, Vijay S Chauhan, Rupin Dalvi, Adrian Suszko, Vijay S Chauhan, Rupin Dalvi, Adrian Suszko, Vijay S Chauhan
Rotors are rotating electrical waves that may sustain atrial fibrillation (AF); thereby providing therapeutic targets for catheter ablation. We propose a method for identifying rotors from circular catheter recordings of bipolar intracardiac electrograms (EGM) during AF. We use dominant frequency-based periodicity detection along with a graph search algorithm to identify the most dominant periodic activations or peaks of interest in each bipolar EGM recorded by a multipolar circular catheter. We then track the activations across catheter bipoles to determine whether they conform to the rotational pattern of a rotor...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227188/conformai-electronics-for-longitudinal-bio-sensing-in-at-home-assistive-and-rehabilitative-devices
#9
John C Batchelor, Stephen G Yeates, Alexander J Casson, John C Batchelor, Stephen G Yeates, Alexander J Casson, Stephen G Yeates, John C Batchelor, Alexander J Casson
Wearable electronics are revolutionizing personalized and preventative healthcare by allowing the easy, unobtrusive, and long term monitoring of a range of body parameters. Conformal electronics which attach directly to the skin in a very robust and long term manner are envisioned as the next generation of highly portable miniaturized computing devices, beyond wearables. In this paper we overview the state-of-the-art in conformal electronics created using silver nanoparticle inkjet printed techniques for home assistive and rehabilitative devices...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227157/meandered-conformai-antenna-for-ism-band-ingestible-capsule-communication-systems
#10
Md Shamsul Arefin, Jean-Michel Redoute, Mehmet Rasit Yuce, Md Shamsul Arefin, Jean-Michel Redoute, Mehmet Rasit Yuce, Jean-Michel Redoute
The wireless capsule has been used to measure physiological parameters in the gastrointestinal tract where communication from in-body to external receiver is necessary using a miniaturized antenna with high gain and onmidirectional radiation pattern. This paper presents a meandered conformal antenna with center frequency of 433 MHz for a wireless link between an in-body capsule system and an ex-body receiver system. The antenna is wrapped around the wireless capsule, which provides extra space for other circuits and sensors inside the capsule as well as allows it having larger dimensions compared to inner antennas...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226213/an-oscillatory-reaction-induced-periodic-c-quadruplex-dna-gating-of-artificial-ion-channels
#11
Jian Wang, Ruochen Fang, Jue Hou, Huacheng Zhang, Ye Tian, Huanting Wang, Lei Jiang
Many biological ion channels controlled by biochemical reactions have autonomous and periodic gating functions, which play important roles in continuous mass transport and signal transmission of living systems. Inspired by these functional biological ion channel systems, here we report an artificial self-oscillating nanochannel system that can autonomously and periodically control its gating process under constant conditions. The system is constructed by integrating a chemical oscillator, consisting of BrO3-, Fe(CN)64-, H+, and SO32-, into a synthetic proton-sensitive nanochannel modified with C-quadruplex (C4) DNA motors...
February 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28225797/use-of-bovine-recombinant-prion-protein-and-real-time-quaking-induced-conversion-to-detect-cattle-transmissible-mink-encephalopathy-prions-and-discriminate-classical-and-atypical-l-and-h-type-bovine-spongiform-encephalopathy
#12
Soyoun Hwang, Justin J Greenlee, Eric M Nicholson
Prions are amyloid-forming proteins that cause transmissible spongiform encephalopathies through a process involving conversion from the normal cellular prion protein to the pathogenic misfolded conformation (PrPSc). This conversion has been used for in vitro assays including serial protein misfolding amplification and real-time quaking induced conversion (RT-QuIC). RT-QuIC can be used for the detection of prions in a variety of biological tissues from humans and animals. Extensive work has been done to demonstrate that RT-QuIC is a rapid, specific, and highly sensitive prion detection assay...
2017: PloS One
https://www.readbyqxmd.com/read/28225631/conformational-changes-in-c-reactive-protein-affect-binding-to-curved-membranes-in-a-lipid-bilayer-model-of-the-apoptotic-cell-surface
#13
Aml Abd Alnaas, Carrie L Moon, Mitchell Alton, Scott M Reed, Michelle K Knowles
C-reactive protein (CRP) is a serum protein that binds to damaged membranes through a phosphatidylcholine binding site. The membrane binding process can initiate the complement immune response and facilitates the clearance of apoptotic cells, likely aiding in the protection of autoimmunity. The initiation of an immune response relies on a conformation change from a native, pentameric form to a modified form, where the modified form binds complement proteins (i.e. C1q) and regulatory proteins substantially better than the native form...
February 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28225627/1-2-3-triazolium-based-peptoid-oligomers
#14
Hafida Aliouat, Cécile Caumes, Olivier Roy, Mohamed Zouikri, Claude Taillefumier, Sophie Faure
The cis-directing effect of the 1,2,3-triazolium-type side chain was studied on dimeric peptoid models with various patterns: αα, αβ, βα and ββ. Low influences of the sequence and of the solvent were observed, the cis conformation of the amide carrying the triazolium ranging from 83 to 94% in proportion. The synthesis of peptoid homooligomers with four or eight pendant 1,2,3-triazolium side chains is described. α-, β- and α,β-peptoids carrying propargyl groups were subjected to CuAAC reaction using alkyl azides, and the resulting triazoles were quaternized providing well-defined multitriazolium platforms...
February 22, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28225609/regulation-and-plasticity-of-catalysis-in-enzymes-insights-from-analysis-of-mechanochemical-coupling-in-myosin
#15
Xiya Lu, Victor Ovchinnikov, Darren Demapan, Daniel Roston, Qiang Cui
The mechanism of ATP hydrolysis in the myosin motor domain is analyzed using a combination of DFTB3/CHARMM simulations and enhanced sampling techniques. The motor domain is modeled in the pre-powerstroke state, in the post-rigor state, and a hybrid model based on the post-rigor state with a closed nucleotide-binding pocket. The ATP hydrolysis activity is found to depend on the positioning of nearby water molecules, and a network of polar residues facilitates proton transfer and charge redistribution during hydrolysis...
February 22, 2017: Biochemistry
https://www.readbyqxmd.com/read/28225592/controlling-agglomeration-of-protein-aggregates-for-structure-formation-in-liquid-oil-a-sticky-business
#16
Auke de Vries, Yuly Lopez Gomez, Bas Jansen, Erik van der Linden, Elke Scholten
Proteins are known to be effective building blocks when it comes to structure formation in aqueous environments. Recently, we have shown that submicron colloidal protein particles can also be used to provide structure to liquid oil and form so-called oleogels.1 Preventing extensive agglomeration of these submicron building blocks is a prerequisite to allow for efficient structure formation. This was achieved by applying a solvent exchange procedure to transfer the building blocks from water to oil. The aim of the current paper was to elucidate on the enhanced stability against agglomeration of heat-set whey protein isolate (WPI) aggregates in oil after applying such a solvent exchange procedure...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28225587/compms2miner-an-automatable-metabolite-identification-visualization-and-data-sharing-r-package-for-high-resolution-lc-ms-datasets
#17
William Matthew Bell Edmands, Lauren M Petrick, Dinesh Kumar Barupal, Augustin Scalbert, Mark Wilson, Jeffrey Wickliffe, Stephen M Rappaport
A long-standing challenge of untargeted metabolomic profiling by ultrahigh performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) is efficient transition from unknown mass spectral features to confident metabolite annotations. The compMS2Miner (Comprehensive MS2 Miner) package was developed in the R language to facilitate rapid, comprehensive feature annotation using a peak-picker-output and MS2 data files as inputs. The number of MS2 spectra that can be collected during a metabolomic profiling experiment far outweigh the amount of time required for pain-staking manual interpretation, therefore a degree of software workflow autonomy is required for broad-scale metabolite annotation...
February 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28225485/magnetic-resonance-mr-imaging-for-tumor-staging-and-definition-of-tumor-volumes-on-radiation-treatment-planning-in-nonsmall-cell-lung-cancer-a-prospective-radiographic-cohort-study-of-single-center-clinical-outcome
#18
Dan Zhao, Qiaoqiao Hu, Liping Qi, Juan Wang, Hao Wu, Guangying Zhu, Huiming Yu
We investigate the impact of magnetic resonance (MR) on the staging and radiotherapy planning for patients with nonsmall cell lung cancer (NSCLC).A total of 24 patients with NSCLC underwent MRI, which was fused with radiotherapy planning CT using rigid registration. Gross tumor volume (GTV) was delineated not only according to CT image alone (GTVCT), but also based on both CT and MR image (GTVCT/MR). For each patient, 2 conformal treatment plans were made according to GTVCT and GTVCT/MR, respectively. Dose-volume histograms (DVH) for lesion and normal organs were generated using both GTVCT and GTVCT/MR treatment plans...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28225314/the-prevalence-of-colonic-polyps-in-patients-with-acromegaly-a-case-control-nested-in-a-cohort-colonoscopic-study
#19
Baldomero Gonzalez, Guadalupe Vargas, Victoria Mendoza, Mariana Nava, Moisés Rojas, Moisés Mercado
BACKGROUND: Acromegaly is associated with an increased risk of colonic polyps. The magnitude of such risk is controversial and the characteristics that distinguish patients who develop polyps from those who do not are not well established. OBJECTIVE: To determine the prevalence of colonic polyps upon the diagnosis of acromegaly. To compare the clinical and biochemical features of patients with and without polyps Patients and methods: Out of 165 patients who underwent a full colonoscopy upon diagnosis of acromegaly, 53 were found to harbor colonic lesions (cases), whereas the remaining 112 conformed the group of controls...
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28225269/indazole-based-covalent-inhibitors-to-target-drug-resistant-epidermal-growth-factor-receptor
#20
Stefano Tomassi, Jonas Lategahn, Julian Engel, Marina Keul, Hannah Lea Tumbrink, Julia Ketzer, Thomas Mühlenberg, Matthias Baumann, Carsten Schultz-Fademrecht, Sebastian Bauer, Daniel Rauh
The specific targeting of oncogenic mutant epidermal growth factor receptor (EGFR) is a breakthrough in targeted cancer therapy and marks a drastic change in the treatment of non-small cell lung cancer (NSCLC). The recurrent emergence of resistance to these targeted drugs requires the development of novel chemical entities that efficiently inhibit drug-resistant EGFR. Herein, we report the optimization process for a hit compound that has emerged from a phenotypic screen resulting in indazole-based compounds...
February 22, 2017: Journal of Medicinal Chemistry
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