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Nicholas J Connors, Lewis S Nelson
INTRODUCTION: Opioid abuse and opioid overdose deaths have increased significantly over the past decade. Naloxone is a potentially life-saving medication that can reverse opioid-induced respiratory depression, though precipitated opioid withdrawal can pose acute risks to the patient and medical personnel. The optimal naloxone dose is unclear and few studies address this question. METHODS: A convenience sample of commonly available references were queried for the recommended IV naloxone dose...
September 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
M Gunell, P Antikainen, N Porjo, K Irjala, J Vakkila, K Hotakainen, S S Kaukoranta, J J Hirvonen, K Saha, R Manninen, B Forsblom, K Rantakokko-Jalava, V Peltola, J O Koskinen, P Huovinen
Respiratory viruses cause seasonal epidemics every year. Several respiratory pathogens are circulating simultaneously and typical symptoms of different respiratory infections are alike, meaning it is challenging to identify and diagnose different respiratory pathogens based on symptoms alone. mariPOC® is an automated, multianalyte antigen test which allows the rapid detection of nine respiratory infection pathogens [influenza A and B viruses, respiratory syncytial virus (RSV), human metapneumovirus, adenovirus, parainfluenza 1-3 viruses and pneumococci] from a single nasopharyngeal swab or aspirate samples, and, in addition, can be linked to laboratory information systems...
March 2016: European Journal of Clinical Microbiology & Infectious Diseases
Serdar Alan, Omer Erdeve, Ufuk Cakir, Hasan Akduman, Aysegul Zenciroglu, Mustafa Akcakus, Turan Tunc, Zeynel Gokmen, Can Ates, Begum Atasay, Saadet Arsan
AIM: To determine the incidence and outcomes of respiratory syncytial virus (RSV)-related acute lower respiratory tract infection (ALRI) including morbidity, nosocomial infection and mortality among newborn infants who were admitted to the neonatal intensive care units (NICUs). METHODS: A multicenter, prospective study was conducted in newborns who were hospitalized with community acquired or nosocomial RSV infection in 44 NICUs throughout Turkey. Newborns with ALRI were screened for RSV infection by Respi-Strip®-test...
2016: Journal of Maternal-fetal & Neonatal Medicine
Sara Sanbonmatsu-Gámez, Mercedes Pérez-Ruiz, Ana Lara-Oya, Irene Pedrosa-Corral, Cristina Riazzo-Damas, José María Navarro-Marí
The analytical performance of mariPOC® respi test (ArcDia® Laboratories, Turku, Finland) was evaluated using nucleic acid amplification techniques (NAATs) as the gold standard. The mariPOC assay allows automated detection of antigens from 8 respiratory viruses: influenza A and B viruses, respiratory syncytial virus, adenovirus, human metapneumovirus, and parainfluenza viruses 1-3. Positive results from samples with high viral load are available in 20min. Nasopharyngeal aspirates (n=192) from patients with acute respiratory infection and from previously positive samples were analyzed by mariPOC and NAATs (Simplexa(TM) FluA/FluB & RSV kit [n=118] and Luminex® Respiratory virus panel xTAG® RVP FAST [n=74])...
November 2015: Diagnostic Microbiology and Infectious Disease
Ganimeta Bakalovic, Amra Dzinovic, Rusmir Baljic, Selma Dizdar, Amina Selimovic
OBJECTIVE: To present the epidemiological features of bronchiolitis in a one-year period in patients of Pediatric Clinic, Clinical Centre of Sarajevo University. INTRODUCTION: Bronchiolitis is the most common respiratory infection of early infant age. The disease is one the most common reason for hospitalization of children under the age of six months. The disease is characterized by occurrences in the winter season November-March. For daily diagnosing of severe forms of bronchiolitis as a clinical syndrome, often sufficient are the knowledge of the epidemiological data, age of the patient, clinical examination and insight into the risk factors...
June 2015: Materia Socio-medica
Senem Alkan Ozdemir, Esra Arun Ozer, Yeliz Pekcevik, Ozkan Ilhan, Sumer Sutcuoglu
OBJECTIVE: Respiratory syncytial virus (RSV) lower respiratory tract infection is the most common viral infection in childhood. RSV-infected infants demonstrate various radiographic findings. The aim of the study is to evaluate whether assessment of radiological characteristics of lower tract infection due to RSV may be a predictor of clinical outcome in newborns. METHODS: The study included 36 newborn infants hospitalized for lower tract infection. In order to detect RSV, RSV Respi-Strip (Coris Bioconcept Organization) test kits were used on admission...
2015: Journal of Maternal-fetal & Neonatal Medicine
Hua Wang, Jing Liu, Jian-Min Liu, Jing-Fang Lü, Ming-Yang Chen, Jing-Zhi Wang
OBJECTIVE: To observe the effect of electroacupuncture (EA) of "Guanyuan" (CV 4) and bilateral "Housanli" (ST 36) plus acupuncture stimulation of "Baihui" (GV 20) [an acupoint recipe for "Shuanggu Yitong" (strengthening both congenital foundation and the acquired constitution and regulating the yang-qi of the body] on the anti-fatigue ability and liver mitochondrial respiratory function in yang-deficiency ageing rats. METHODS: A total of 48 male SD rats were equally and randomly divided into normal control, model, EA and EA control groups...
August 2013: Zhen Ci Yan Jiu, Acupuncture Research
Mustafa Hacımustafaoğlu, Solmaz Celebi, Sefika Elmas Bozdemir, Taner Ozgür, Ismail Ozcan, Atilla Güray, Deniz Cakır
Respiratory syncytial virus (RSV) is the most frequent agent of acute lower respiratory diseases and creates a significant burden of disease in children under 5 years all over the world. RSV causes severe lower respiratory tract infections (LRTI) that require hospitalization, especially in children ≤2 years. The aim of this study was to determine the incidence of RSV in children ≤2 years of age hospitalized for LRTI. Children ≤2 years of age hospitalized for one year for LRTI in the three largest hospitals of Bursa City Center, Turkey were evaluated...
March 2013: Turkish Journal of Pediatrics
W Socha, J Rola
Three different rapid strip tests: TRU RSV, BinaxNOW RSV and RSV Respi-strip were compared with RT-PCR and ELISA BRSV Ag for the ability to detect bovine respiratory syncytial virus (BRSV) in nasal swabs collected from calves experimentally vaccinated with live vaccine Rispoval RS-PI3. The reference strains of BRSV (375 and A51908) were detected by ELISA BRSV Ag whereas the strains of human respiratory syncytial virus (HRSV) and bovine parainfluenza virus type 3 (BPIV-3) were not. All rapid strip tests as well as RT-PCR reacted positively both to HRSV and BRSV reference strains and negatively to BPIV-3...
2012: Polish Journal of Veterinary Sciences
(no author information available yet)
Respiratory syncytial virus (RSV) infections may cause severe respiratory diseases, particularly in infants and young children. In order to determine the timing of prophylaxis, the seasonal variations of RSV had to be determined. We report the climate-related results of an epidemiological study conducted in 32 hospitals of Turkey between May 2008 and September 2010, on children < 2 years of age hospitalized with lower respiratory tract infection. Information on socio-demographics, medical history, risk factors for RSV, diagnosis and severity of RSV, and hospitalization was recorded...
May 2012: Turkish Journal of Pediatrics
M Reynders, M De Foor, Y Maaroufi, I Thomas, A Vergison, S Debulpaep, O Vandenberg, F Crokaert
PURPOSE: Evaluation of the performance of two rapid (15') antigen detection tests (RAT), BinaxNOW Influenza A&B and Coris Influ-A&B Respi-Strip for the detection of A(H1N1)v2009. STUDY DESIGN: Between July 2009 and November 2009, 4105 respiratory specimens from patients with influenza-like illness attending seven public hospitals in Brussels were prospectively examined by two immunochromatographic RAT, followed by viral culture and/or specific real-time RT-PCR. RESULTS: Samples consisted predominantly of nasopharyngeal aspirates (NPA-41%), nasopharyngeal (NPS-37%) and throat swabs (TS-14%)...
March 2012: Acta Clinica Belgica
E A Dizdar, C Aydemir, O Erdeve, F N Sari, S Oguz, N Uras, U Dilmen
Palivizumab is currently licensed for the prevention of respiratory syncytial virus (RSV) lower respiratory tract disease in infants and children with chronic lung disease, with a history of preterm birth, or with haemodynamically significant congenital heart disease, but its routine use during outbreaks in neonatal intensive care units (NICUs) is not currently recommended. Here we report an outbreak in a NICU detected during a screening trial for RSV infection using a rapid antigen test (Respi-Strip((R)))...
August 2010: Journal of Hospital Infection
Manda L Waldrep, Yingxin Zhuang, Harry W Schroeder
BACKGROUND: Recent reports have suggested that Common Variable Immunodeficieny (CVID) can present as an autosomal dominant trait dependent on the inheritance of a set of uncommon mutations/alleles of TACI (transmembrane activator and calcium-modulator and cyclophilin ligand interactor) involving exons 3 or 4. Penetrance, however, appears to be incomplete. Among our clinic population, the greatest genetic linkage for CVID is to the major histocompatibility complex (MHC) on chromosome 6...
2009: BMC Medical Genetics
C Steininger, M Redlberger, W Graninger, M Kundi, T Popow-Kraupp
Rapid and reliable diagnosis of influenza is essential for identification of contagious patients and effective patient management. Near-patient assays allow establishment of the diagnosis within minutes in young children, and this study aimed to evaluate near-patient assays in relation to the patient's age. A total of 194 patients with laboratory-confirmed influenza A/H3N2 virus infection, diagnosed within a prospective cohort study, were included. Cryopreserved nasopharyngeal swabs collected from these patients were tested by four near-patient assays (Binax Now Influenza A&B, Quick S-Influ A/B, Influ-A&B Respi-Strip, and Actim Influenza A&B)...
March 2009: Clinical Microbiology and Infection
Uma Sundar, Vimal Pahuja, Nishant Dwivedi, Murar E Yeolekar
AIMS: The study aimed at correlation of post-stroke dysphagia with area and volume of infarct/ bleed, and with subsequent in-hospital respiratory morbidity and mortality. MATERIALS AND METHODS: 50 patients of acute stroke were serially recruited. Standard Staff swallowing assessment was performed within 24 hours of admission along with pulse oximetry. Ischemic strokes were classified as per OCPS registry. In-hospital respiratory morbidity and mortality, mode of nutrition and disability status at discharge were noted...
October 2008: Neurology India
Douglas T Johnston, Gregory Mehaffey, Judy Thomas, K Randall Young, Howard Wiener, Jian Li, Rodney C P Go, Harry W Schroeder
To test whether MHC alleles associated with common variable immune deficiency (CVID) might also be over-represented in patients with normal serum immunoglobulin levels who suffer with recurrent sinopulmonary infections (RESPI), we identified 62 consecutive RESPI patients and compared their HLA-B and HLA-DR antigen frequencies to those of 60 consecutive patients with CVID, 1627 Alabama Caucasian bone marrow donors, and 997,230 published US Caucasians. Either HLA-B44, -B8, -DR3(17), or -DR7 was present in 74% of the RESPI and 85% of the CVID patients...
June 2006: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Norma Hernández-Trejo, Oliver Kayser, Hartwig Steckel, Rainer H Müller
The poorly soluble drug buparvaquone is proposed as an alternative treatment of Pneumocystis carinii pneumonia (PCP) lung infections. Physically stable nanosuspensions were formulated in order to deliver the drug at the site of infection using nebulization. The aerosolization characteristics of two buparvaquone nanosuspensions were determined with commercial jet and ultrasonic nebulizer devices. Aerosol droplet size distribution was determined with laser diffractometry (LD). Nebulization of the nanosuspensions and dispersion media surfactant solutions produced aerosol droplets diameters in the range from 3 to 5 microm for Respi-jet Kendall, Pari Turbo Boy system and Multisonic nebulizers and particles around 9-10 microm with Omron U1...
September 2005: Journal of Drug Targeting
D Gregson, T Lloyd, S Buchan, D Church
The RSV Respi-Strip was compared to the SimulFluor respiratory screen for detecting respiratory syncytial virus in nasopharyngeal aspirates from pediatric patients. Of samples tested, 115/239 (49%) were positive by direct fluorescent-antigen detection. The sensitivity and specificity of the RSV Respi-Strip were 92% (95% confidence interval [CI], 86% to 96%) and 98% (95% CI, 94% to 100%), respectively, with a diagnostic efficiency of 95%.
November 2005: Journal of Clinical Microbiology
Vijaya V Mysorekar, Chitralekha P Dandekar, B S Satya Prakash
Mast cells are known to be effector cells in various inflammatory reactions, but their role in gastritis is unclear. The present study was undertaken to investigate the extent of mast cell involvement in antral gastritis with and without Helicobacter pylori (H. pylori) infection and thus evaluate the possible role of mast cells in the pathogenesis of H. pylori-associated gastritis. Antral mucosal biopsies were taken from 212 subjects with symptoms suggestive of acid peptic disease. Sections were assessed for inflammation...
October 2003: Indian Journal of Pathology & Microbiology
Edilberto Bermudez, James B Mangum, Brian A Wong, Bahman Asgharian, Paul M Hext, David B Warheit, Jeffrey I Everitt
A multispecies, subchronic, inhalation study comparing pulmonary responses to ultrafine titanium dioxide (uf-TiO(2)) was performed. Female rats, mice, and hamsters were exposed to aerosol concentrations of 0.5, 2.0, or 10 mg/m(3) uf-TiO(2) particles for 6 h/day, 5 days/week, for 13 weeks. Following the exposure period, animals were held for recovery periods of 4, 13, 26, or 52 weeks (49 weeks for the uf-TiO(2)-exposed hamsters) and, at each time point, uf-TiO(2) burdens in the lung and lymph nodes and selected lung responses were examined...
February 2004: Toxicological Sciences: An Official Journal of the Society of Toxicology
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