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C reactive protein whipple

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https://www.readbyqxmd.com/read/19669084/an-unusual-cause-of-diarrhoea-and-arthritis
#1
Sharmin Nizam, Annette Johnstone, Jo Ridpath, Gareth Davies, Andrew Gough
A 41-year-old lady was investigated by several hospital teams over a 5-year period. She initially presented with arthralgia but over time developed a myriad of signs and symptoms. Later, she was admitted for investigation of profound weight loss, anaemia and a rising C-reactive protein. Extensive gastrointestinal investigations were performed. Duodenal biopsy revealed microscopic evidence of villous blunting with prominent collections of macrophages within the lamina propria and submucosa. These changes were consistent with Whipple's disease and confirmed by polymerase chain reaction on the biopsy sample...
March 2013: Clinical Rheumatology
https://www.readbyqxmd.com/read/18575052/an-atypical-case-of-whipple-s-disease-case-report-and-review-of-the-literature
#2
I Nubourgh, F Vandergheynst, P Lefebvre, A Lemy, N Dumarey, G Decaux
We report the case of a 57-year-old man, presenting with bilateral panuveitis, bilateral sacroiliitis, intermittent pyrexia and a pulmonary nodule. The patient had been under immunosuppressive treatment for 2 years for Behçet's disease. However, he did not fulfill the diagnostic criteria of Behçet's disease. Blood analysis showed a very high C reactive protein (CRP at 34 mg/dl). In view of severe intra-ocular inflammation, the anterior chamber was punctured. Polymerase chain reaction (PCR) on the aqueous humour and on the blood revealed the presence of Tropheryma whippelii DNA, an agent responsible for Whipple's disease...
March 2008: Acta Clinica Belgica
https://www.readbyqxmd.com/read/18346413/-whipple-s-disease-analysis-of-6-cases
#3
REVIEW
Raquel Reyes, Pilar Peris, Faust Feu, Angels Martínez-Ferrer, Angels Quera, Nuria Guañabens
BACKGROUND AND OBJECTIVE: Whipple's disease (WD) is an infrequent multisystemic process, with a bacterial etiology and with a marked variability in relation to its clinical manifestations. The diagnosis is established by histopathologic study or by polymerase chain reaction (PCR) test. Our objective was to analyze the clinical characteristics and evolution of these patients. PATIENTS AND METHOD: We have reviewed the patients diagnosed with WD in our hospital during the last 20 years (1987-2007)...
February 23, 2008: Medicina Clínica
https://www.readbyqxmd.com/read/15242948/use-of-recombinant-esat-6-cfp-10-fusion-protein-for-differentiation-of-infections-of-cattle-by-mycobacterium-bovis-and-by-m-avium-subsp-avium-and-m-avium-subsp-paratuberculosis
#4
COMPARATIVE STUDY
W R Waters, B J Nonnecke, M V Palmer, S Robbe-Austermann, J P Bannantine, J R Stabel, D L Whipple, J B Payeur, D M Estes, J E Pitzer, F C Minion
Immunological diagnosis of Mycobacterium bovis infection of cattle is often confounded by cross-reactive responses resulting from exposure to other mycobacterial species, especially Mycobacterium avium. Early secretory antigenic target 6 (ESAT-6) and culture filtrate protein 10 (CFP-10) are dominant gamma interferon (IFN-gamma)-inducing antigens of tuberculous mycobacteria, and they are absent from many environmental nontuberculous mycobacteria. Because M. avium exposure is the primary confounding factor in the diagnosis of M...
July 2004: Clinical and Diagnostic Laboratory Immunology
https://www.readbyqxmd.com/read/12615449/immune-responses-of-elk-to-mycobacterium-bovis-bacillus-calmette-guerin-vaccination
#5
W R Waters, M V Palmer, S C Olsen, R E Sacco, D L Whipple
Although rare, detection of Mycobacterium bovis infection of captive or free-ranging elk (Cervus elaphus) elicits serious concern due to regulatory and zoonotic implications. Few studies, however, have evaluated the immune response of elk to M. bovis or other pathogens. To model natural infection, elk were vaccinated with live M. bovis bacillus Calmette Guerin (BCG, Pasteur strain) for evaluation of immune responsiveness to this attenuated live vaccine. Peripheral blood mononuclear cells (PBMC) of vaccinated elk proliferated in response to stimulation with a soluble mycobacterial antigen preparation (i...
March 28, 2003: Vaccine
https://www.readbyqxmd.com/read/11777846/monoclonal-antibodies-to-immunodominant-epitope-of-tropheryma-whipplei
#6
Zhongxing Liang, Bernard La Scola, Didier Raoult
Recent isolation of Tropheryma whipplei (formerly Trophyrema whippelii), the agent of Whipple's disease, from the cardiac valve of a patient with Whipple's disease endocarditis now allows the detection of reactive epitopes that could be used in a serological assay. In order to propose an enzyme-linked immunosorbent assay (ELISA) that uses recombinant T. whipplei antigen, we first determined by Western blotting of human, mouse, and rabbit antisera that the common immunodominant epitope is an 84-kDa protein. We then produced 13 monoclonal antibodies (MAbs) against T...
January 2002: Clinical and Diagnostic Laboratory Immunology
https://www.readbyqxmd.com/read/10200523/differences-in-epitope-accessibility-of-p53-monoclonal-antibodies-suggest-at-least-three-conformations-or-states-of-protein-binding-of-p53-protein-in-human-tumor-cell-lines
#7
M K Danks, D O Whipple, C R McPake, D Lu, L C Harris
The p53 tumor suppressor gene is deleted or mutated in over 50% of human tumors. Mutations frequently extend the half-life of the p53 protein; and a high level of nuclear p53 expression, detected by immunohistochemistry, has been used to predict the p53 status of tumors. We compared the sensitivity and reactivity of five frequently used, commercially available monoclonal antibodies (1801, DO1, DO7, BP53.12 and 421) in immunoblot and immunofluorescence assays, and found that results differed among the antibodies...
August 1998: Cell Death and Differentiation
https://www.readbyqxmd.com/read/9894633/rheumatologic-manifestations-of-gastrointestinal-disorders
#8
REVIEW
J Braun, J Sieper
There are many different rheumatic symptoms of gastrointestinal (GI) disorders and a whole range of GI symptoms that occur in rheumatologic disorders. Spondyloarthropathies (SpA) are closely related to the GI tract. Bacterial DNA has been detected in peripheral but not the sacroiliac joints of patients, including enterobacteria; the significance of this finding is not clear yet because antibiotic therapy seems not to be effective. The synovial lymphocyte proliferation of reactive arthritis (ReA) patients to the 60-kD heat-shock protein of Yersinia plays a major role in the immune response...
January 1999: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/6186810/ultrastructure-of-the-synovial-membrane-in-seronegative-inflammatory-arthropathies
#9
C J Morris, M Farr, C A Hollywell, C F Hawkins, D L Scott, K W Walton
The ultrastructure of the synovial membrane has been studied in 6 patients with seronegative inflammatory arthropathies: Reiter's (2), Crohn's (2), Whipple's (1) and Behçet's disease (1). The most striking changes were found in the synovial B cells, many containing abnormally large mitochondria with altered cristae surrounded by fibrillar material. Similar material was present in dilated endoplasmic reticulum which was the probable source of groups of extracellular fibrillar spheroidal bodies. The B cells also contained electron dense granular lysosomes of very variable size which, in common with the abnormal mitochondria, were often associated with bundles of orientated microfilaments and large golgi complexes...
January 1983: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/2579662/response-of-the-acute-phase-reactants-c-reactive-protein-and-serum-amyloid-a-protein-to-antibiotic-treatment-of-whipple-s-disease
#10
J I Reed, J D Sipe, J R Wohlgethan, W G Doos, J J Canoso
No abstract text is available yet for this article.
March 1985: Arthritis and Rheumatism
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