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https://www.readbyqxmd.com/read/28441760/supplementation-with-a-polyphenol-rich-extract-perfload-%C3%A2-improves-physical-performance-during-high-intensity-exercise-a-randomized-double-blind-crossover-trial
#1
Julien Cases, Cindy Romain, Cristian Marín-Pagán, Linda H Chung, José Miguel Rubio-Pérez, Caroline Laurent, Sylvie Gaillet, Emmanuelle Prost-Camus, Michel Prost, Pedro E Alcaraz
Workout capacity is energy-production driven. To produce peak metabolic power outputs, the organism predominantly relies more on anaerobic metabolism, but this undoubtedly has a negative and limiting impact on muscle function and performance. The aim of the study was to evaluate if an innovative polyphenol-based food supplement, PerfLoad(®), was able to improve metabolic homeostasis and physical performance during high-intensity exercises under anaerobic conditions. The effect of a supplementation has been investigated on fifteen recreationally-active male athletes during a randomized, double-blind and crossover clinical investigation...
April 24, 2017: Nutrients
https://www.readbyqxmd.com/read/28437758/balance-impairment-in-kidney-transplant-recipients-without-concurrent-peripheral-neuropathy
#2
T Zanotto, S Gobbo, V Bullo, B Vendramin, F Duregon, L Cugusi, A Di Blasio, L Furian, C Silvestre, D Neunhaeuserer, M Zaccaria, M Bergamin, A Ermolao
Kidney transplant recipients (KTRs) present with compromised functional capacity, low levels of physical activity, muscle atrophy, and peripheral nerve dysfunction that may result in high postural instability. This study aimed to compare the static balance control of 19 KTRs with 19 healthy adults (HA). All participants completed the Romberg test on a stabilometric platform with eyes open (EO), eyes closed (EC) and during a dual task (DT) condition. Centre of pressure (COP) measures (COP velocity (COPv) and sway area (SA)), as well as position-based outcomes such as anterior-posterior (AP) and medio-lateral (ML) ranges of COP displacements were recorded...
April 15, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28436583/physical-activity-and-exercise-for-chronic-pain-in-adults-an-overview-of-cochrane-reviews
#3
REVIEW
Louise J Geneen, R Andrew Moore, Clare Clarke, Denis Martin, Lesley A Colvin, Blair H Smith
BACKGROUND: Chronic pain is defined as pain lasting beyond normal tissue healing time, generally taken to be 12 weeks. It contributes to disability, anxiety, depression, sleep disturbances, poor quality of life, and healthcare costs. Chronic pain has a weighted mean prevalence in adults of 20%.For many years, the treatment choice for chronic pain included recommendations for rest and inactivity. However, exercise may have specific benefits in reducing the severity of chronic pain, as well as more general benefits associated with improved overall physical and mental health, and physical functioning...
April 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28433416/static-postural-control-in-youth-with-osteogenesis-imperfecta-type-i
#4
Annie Pouliot-Laforte, Martin Lemay, Frank Rauch, Louis-Nicolas Veilleux
OBJECTIVE: To assess static postural control in eyes-open and eyes-closed conditions in individuals with osteogenesis imperfecta (OI) type I as compared to typically developing (TD) individuals. The second aim was to explore the relation between postural control and lower-limbs muscle function. DESIGN: This is a cross-sectional study. SETTINGS: The study was carried out in the outpatient department of a pediatric orthopedic hospital. PARTICIPANTS: 22 individuals with OI type I (mean age [range]: 13...
April 19, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28431977/transcriptome-comparison-reveals-insights-into-muscle-response-to-hypoxia-in-blunt-snout-bream-megalobrama-amblycephala
#5
Bo-Xiang Chen, Shao-Kui Yi, Wei-Feng Wang, Yan He, Yan Huang, Ze-Xia Gao, Hong Liu, Wei-Min Wang, Huan-Ling Wang
The economic and biological significance of blunt snout bream (Megalobrama amblycephala) makes this species important to explore the underlying molecular mechanism of hypoxia response. In the present study, we compared the transcriptional responses to serious hypoxia in skeletal muscle among hypoxia tolerant (MT), sensitive (MS) and control (without hypoxia treatment, MC) M. amblycephala obtained according to the time difference of losing balance after hypoxia treatment. A total of 88,200,889 clean reads were generated and assembled into 44,493 unigenes...
April 18, 2017: Gene
https://www.readbyqxmd.com/read/28428900/asymptomatic-severe-vagal-and-sympathetic-cardiac-denervation-in-holmes-adie-s-syndrome
#6
B Estañol, R C Callejas-Rojas, S Cortés, R Martínez-Memije, O Infante-Vázquez, G Delgado-García
A 40-year-old woman was found to have bilateral Adie's pupils and generalized muscle stretch areflexia. She did not have orthostatic hypotension but, in an ECG strip in the office, she appeared to have an almost fixed heart rate. We thus studied the heart rate variability (HRV) and the systolic blood pressure variability (SBPV) in supine and standing position and also during rhythmic breathing. We found a decreased HRV in the time domain with very low standard deviation in supine and standing position and during rhythmic breathing...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28427544/what-s-the-secret-behind-the-benefits-of-whole-body-vibration-training-in-patients-with-copd-a-randomized-controlled-trial
#7
Rainer Gloeckl, Inga Jarosch, Ulrike Bengsch, Magdalena Claus, Tessa Schneeberger, Vasileios Andrianopoulos, Jeffrey W Christle, Wolfgang Hitzl, Klaus Kenn
BACKGROUND: Several studies have shown that whole-body vibration training (WBVT) improves exercise capacity in patients with severe COPD. The aim of this study was to investigate the determinants of improved exercise capacity following WBVT. METHODS: Seventy-four COPD patients (FEV1: 34 ± 9%predicted) were recruited during a 3-week inpatient pulmonary rehabilitation (PR) program. Conventional endurance and strength exercises were supplemented with self-paced dynamic squat training sessions (4bouts*2min, 3times/wk)...
May 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28425239/an-8-week-thoracic-spine-stabilization-exercise-program-improves-postural-back-pain-spine-alignment-postural-sway-and-core-endurance-in-university-students-a-randomized-controlled-study
#8
Şeyda Toprak Çelenay, Derya Özer Kaya
BACKGROUND/AIM: To investigate the effects of an 8-week thoracic stabilization exercise program on back pain, spinal alignment, postural sway, and core endurance in university students. MATERIALS AND METHODS: University students were randomly allocated into exercise (n: 28) and control (n: 25) groups. The exercise program was carried out 3 days a week for 8 weeks. Postural pain, spinal alignment, postural sway, and core endurance were assessed via visual analogue scale, Spinal Mouse, Biodex Balance System, and McGill's trunk muscle endurance tests at the baseline and after 8 weeks of training...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28425231/the-relationship-between-physical-fitness-and-falling-risk-and-fear-of-falling-in-community-dwelling-elderly-people-with-different-physical-activity-levels
#9
Mehmet Duray, Arzu Genç
BACKGROUND/AIM: The aim of this research was to determine the effects of physical activity level (PAL) and physical fitness on falling parameters in community-dwelling elderly people. MATERIALS AND METHODS: Seventy-six elderly people were grouped as low PAL group (group 1, n: 38) and high PAL (group 2, n: 38) according to their PAL scores. PAL was measured by the Physical Activity Scale for the Elderly and muscle strength, muscle endurance, aerobic endurance, and flexibility tests were applied; body mass index (BMI) was calculated for physical fitness measurement...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28424493/regulation-of-intraocular-pressure-by-microrna-cluster-mir-143-145
#10
Xinyu Li, Fangkun Zhao, Mei Xin, Guorong Li, Coralia Luna, Guigang Li, Qinbo Zhou, Yuguang He, Bo Yu, Eric Olson, Pedro Gonzalez, Shusheng Wang
Glaucoma is a major cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP), which causes optic nerve damage and retinal ganglion cell death, is the primary risk factor for blindness in glaucoma patients. IOP is controlled by the balance between aqueous humor secretion from the ciliary body (CB) and its drainage through the trabecular meshwork (TM). How microRNAs (miRs) regulate IOP and glaucoma in vivo is largely unknown. Here we show that miR-143 and miR-145 expression is enriched in the smooth muscle and trabecular meshwork in the eye...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28423480/the-effect-of-high-dose-vitamin-d-supplementation-on-muscular-function-and-quality-of-life-in-postmenopausal-women-a-randomized-controlled-trial
#11
G Grimnes, N Emaus, K D Cashman, R Jorde
OBJECTIVE: Observational studies have suggested positive associations between serum 25-hydroxyvitamin D (25(OH)D) levels and muscular strength, balance and quality of life. Our aim was to examine whether high-dose vitamin D supplementation would improve these measures as compared to standard-dose vitamin D, as well as the possible muscular effects of Single Nucleotide Polymorphisms (SNPs) in genes encoding vitamin D-related enzymes. DESIGN: A 12-month randomized, double-blind, controlled trial where the participants received daily elemental calcium (1,000 mg) plus vitamin D3 (800 IU)...
April 19, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28423061/muscle-contributions-to-medial-tibiofemoral-compartment-contact-loading-following-acl-reconstruction-using-semitendinosus-and-gracilis-tendon-grafts
#12
Jason M Konrath, David J Saxby, Bryce A Killen, Claudio Pizzolato, Christopher J Vertullo, Rod S Barrett, David G Lloyd
BACKGROUND: The muscle-tendon properties of the semitendinosus (ST) and gracilis (GR) are substantially altered following tendon harvest for the purpose of anterior cruciate ligament reconstruction (ACLR). This study adopted a musculoskeletal modelling approach to determine how the changes to the ST and GR muscle-tendon properties alter their contribution to medial compartment contact loading within the tibiofemoral joint in post ACLR patients, and the extent to which other muscles compensate under the same external loading conditions during walking, running and sidestep cutting...
2017: PloS One
https://www.readbyqxmd.com/read/28422542/routine-yoga-practice-impacts-whole-body-protein-utilization-in-healthy-women
#13
Megan Colletto, Nancy Rodriguez
Whole body protein utilization (WBPU), which includes flux (Q), protein synthesis (PS), protein breakdown (PB), and whole body protein balance (WBPB), provides insight regarding muscle mass, a criterion for sarcopenia. PURPOSE: To characterize yoga's impact on WBPU, body composition and functional measures in healthy (50-65y) women. METHODS: WBPU and functional measures were compared between women who routinely practiced yoga (YOGA; n=7) and non-active counterparts (CON; n=8)...
April 19, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28422523/can-the-lamberts-submaximal-cycle-test-reflect-overreaching-in-professional-cyclists
#14
Lieselot Decroix, Robert P Lamberts, Romain Meeusen
PURPOSE: The Lamberts and Lambert Submaximal Cycle Test (LSCT) consists of 3 stages during which cyclist's cycle for 6 minutes at 60%, 6 minutes at 80% and 3 minutes at 90% of their maximal heart rate, followed by one-minute recovery. It was the aim of this study to determine if the LSCT is able to reflect a state of functional overreaching in professional female cyclists during an 8-day training camp and the following recovery days. METHODS: Six professional female cyclists performed an LSCT on day 1, day 5 and day 8 of the training camp and 3 days after the training camp...
April 19, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28422306/development-of-a-novel-frailty-index-to-predict-mortality-in-patients-with-end-stage-liver-disease
#15
Jennifer C Lai, Kenneth E Covinsky, Jennifer L Dodge, W John Boscardin, Dorry L Segev, John P Roberts, Sandy Feng
BACKGROUND: Cirrhosis is characterized by muscle wasting, malnutrition, and functional decline that confer excess mortality not well quantified by the MELDNa score. We aimed to develop a frailty index to capture these extrahepatic complications of cirrhosis and enhance mortality prediction in cirrhotics. METHODS: Consecutive outpatients listed for LT at a single transplant center without MELD exceptions were assessed with candidate frailty measures. Best subset selection analyses with Cox regression identified subsets of frailty measures that predicted waitlist mortality (=death or delisting due to sickness)...
April 19, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28421001/defining-the-balance-between-regeneration-and-pathological-ossification-in-skeletal-muscle-following-traumatic-injury
#16
REVIEW
Owen G Davies, Yang Liu, Darren J Player, Neil R W Martin, Liam M Grover, Mark P Lewis
Heterotopic ossification (HO) is characterized by the formation of bone at atypical sites. This type of ectopic bone formation is most prominent in skeletal muscle, most frequently resulting as a consequence of physical trauma and associated with aberrant tissue regeneration. The condition is debilitating, reducing a patient's range of motion and potentially causing severe pathologies resulting from nerve and vascular compression. Despite efforts to understand the pathological processes governing HO, there remains a lack of consensus regarding the micro-environmental conditions conducive to its formation, and attempting to define the balance between muscle regeneration and pathological ossification remains complex...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28415899/specific-muscle-synergies-in-national-elite-female-ice-hockey-players-in-response-to-unexpected-external-perturbation
#17
Minhee Kim, Yushin Kim, Hyeyoung Kim, BumChul Yoon
This study aimed to investigate specific muscle synergies in elite ice hockey players indicating highly developed postural control strategies used to restore balance against unexpected external perturbations. Seven elite athletes (EA) on the women's national ice hockey team and 7 non-athletes (NA) participated in this study. Based on trajectories of centre of mass (COM), analysis periods were divided into an initial phase (a balance disturbance after perturbation onset) and a reversal phase (a balance recovery response), respectively...
April 18, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28409595/exercise-prescriptions-in-older-adults
#18
Pearl Guozhu Lee, Elizabeth A Jackson, Caroline R Richardson
Regular physical activity and exercise are important for healthy aging and are beneficial for chronic disease management. Exercise prescriptions for older adults should account for the individual's health status and functional capacity. Any amount of exercise is better than being sedentary, even if health status prevents a person from achieving recommended goals. For most health outcomes, more benefits occur with physical activity performed at higher intensity, greater frequency, or longer duration. Guidelines recommend at least 150 minutes of moderate-intensity aerobic activity or 75 minutes of vigorous-intensity aerobic activity and at least two days of muscle-strengthening activities per week...
April 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28409313/extracellular-regulation-of-the-mitotic-spindle-and-fate-determinants-driving-asymmetric-cell-division
#19
Prestina Smith, Mark Azzam, Lindsay Hinck
Stem cells use mode of cell division, symmetric (SCD) versus asymmetric (ACD), to balance expansion with self-renewal and the generation of daughter cells with different cell fates. Studies in model organisms have identified intrinsic mechanisms that govern this process, which involves partitioning molecular components between daughter cells, frequently through the regulation of the mitotic spindle. Research performed in vertebrate tissues is revealing both conservation of these intrinsic mechanisms and crucial roles for extrinsic cues in regulating the frequency of these divisions...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/28407788/absence-of-neurological-abnormalities-in-mice-homozygous-for-the-polr3a-g672e-hypomyelinating-leukodystrophy-mutation
#20
Karine Choquet, Sharon Yang, Robyn D Moir, Diane Forget, Roxanne Larivière, Annie Bouchard, Christian Poitras, Nicolas Sgarioto, Marie-Josée Dicaire, Forough Noohi, Timothy E Kennedy, Joseph Rochford, Geneviève Bernard, Martin Teichmann, Benoit Coulombe, Ian M Willis, Claudia L Kleinman, Bernard Brais
Recessive mutations in the ubiquitously expressed POLR3A gene cause one of the most frequent forms of childhood-onset hypomyelinating leukodystrophy (HLD): POLR3-HLD. POLR3A encodes the largest subunit of RNA Polymerase III (Pol III), which is responsible for the transcription of transfer RNAs (tRNAs) and a large array of other small non-coding RNAs. In order to study the central nervous system pathophysiology of the disease, we introduced the French Canadian founder Polr3a mutation c.2015G > A (p.G672E) in mice, generating homozygous knock-in (KI/KI) as well as compound heterozygous mice for one Polr3a KI and one null allele (KI/KO)...
April 13, 2017: Molecular Brain
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