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https://www.readbyqxmd.com/read/29331378/loss-of-zebrafish-smyd1a-interferes-with-myofibrillar-integrity-without-triggering-the-misfolded-myosin-response
#1
Christoph Paone, Steven Rudeck, Christelle Etard, Uwe Strähle, Wolfgang Rottbauer, Steffen Just
Sarcomeric protein turnover needs to be tightly balanced to assure proper assembly and renewal of sarcomeric units within muscle tissues. The mechanisms regulating these fundamental processes are only poorly understood, but of great clinical importance since many cardiac and skeletal muscle diseases are associated with defective sarcomeric organization. The SET- and MYND domain containing protein 1b (Smyd1b) is known to play a crucial role in myofibrillogenesis by functionally interacting with the myosin chaperones Unc45b and Hsp90α1...
January 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29330572/effects-of-whole-body-vibration-on-muscle-strength-bone-mineral-content-and-density-and-balance-and-body-composition-of-children-and-adolescents-with-down-syndrome-a-systematic-review
#2
REVIEW
M B Saquetto, F F Pereira, R S Queiroz, C M da Silva, C S Conceição, M Gomes Neto
The aim of this study is to verify the effects of whole-body vibration (WBV) training on the muscle strength of children and adolescents with Down syndrome. We searched MEDLINE, Cochrane, SciELO, Lilacs and PUBMED databases and included manual searches to identify randomised controlled trials to investigate the effects of WBV on the structure and body function of children and adolescents with Down syndrome. Two reviewers independently selected the studies and performed statistical analysis. In total, five studies with 171 patients that compared WBV with exercise and/or control were included...
January 12, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29329971/muscle-quality-is-associated-with-dynamic-balance-fear-of-falling-and-falls-in-older-women
#3
André Bonadias Gadelha, Silvia Gonçalves Ricci Neri, Otávio Toledo Nóbrega, Juscélia Cristina Pereira, Martim Bottaro, Andrew Fonsêca, Ricardo M Lima
No abstract text is available yet for this article.
January 9, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29328985/standing-on-a-sliding-board-affects-generation-of-anticipatory-and-compensatory-postural-adjustments
#4
Bing Chen, Yun-Ju Lee, Alexander S Aruin
Postural control is compromised in the presence of body instability. We studied anticipatory and compensatory postural adjustments people use to maintain balance while standing on an unstable surface and performing voluntary arm movements. Nine healthy participants stood on a sliding board (that was either locked and as such motionless or unlocked and as such free to move in the anterior-posterior direction) and performed fast bilateral arms flexion. Arm acceleration, bilateral electromyographic activity (EMG) of the trunk and lower extremity muscles and center of pressure (COP) displacements were recorded and analyzed within the intervals typical for the anticipatory (APAs) and compensatory (CPAs) postural adjustments...
December 28, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29326901/short-term-effects-of-theracurmin-dose-and-exercise-type-on-pain-walking-ability-and-muscle-function-in-patients-with-knee-osteoarthritis
#5
Yun-A Shin, Min-Hwa Suk, Hee-Seung Jang, Hye-Jung Choi
The purpose of this study was to investigate the short-term of Theracurmin dose and exercise type on pain, walking ability, and muscle function in patients with knee osteoarthritis. Twenty-five patients with knee osteoarthritis randomly selected to Theracurmin intake (T) group and Theracurmin in combined with exercise (T+E) group. T group (n= 13) was taken orally a capsule of 700 mg, 3 times per day, (total 2,100 mg, 35 mg/kg-body weight). T+E group (n= 12) performed aerobic training of 30-min walking and weight training for increasing leg muscular strength...
December 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29326534/is-exercise-training-appropriate-for-patients-with-advanced-heart-failure-receiving-continuous-inotropic-infusion-a-review
#6
REVIEW
Eisuke Amiya, Masanobu Taya
Exercise-based rehabilitation programs have been reported to have beneficial effects for patients with heart failure. However, there is little evidence about whether this is the case in patients with more severe heart failure. In particular, there is a question in the clinical setting whether patients with advanced heart failure and continuous inotropic infusion should be prescribed exercise training. In contrast, many studies conclude that prolonged immobility associated with heart failure profoundly impairs physical function and promotes muscle wasting that could further hasten the course of heart failure...
2018: Clinical Medicine Insights. Cardiology
https://www.readbyqxmd.com/read/29322310/relationship-between-sagittal-spinal-curves-geometry-and-isokinetic-trunk-muscle-strength-in-adults
#7
Walaa Elsayed, Ahmed Farrag, Qassim Muaidi, Nora Almulhim
PURPOSE: Sagittal spinal deviation has been reported to be a significant musculoskeletal problem affecting both genders and could develop at any age. Factors triggering this issue are still not well defined. The purpose of this study was to investigate the relationship between sagittal spine angles and isokinetic peak, average torque, and power of trunk muscles in asymptomatic adults. METHODS: A convenient sample of 79 subjects with asymptomatic spine participated in this study...
January 10, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29322107/the-effect-of-light-touch-on-balance-control-during-overground-walking-in-healthy-young-adults
#8
A R Oates, J Unger, C M Arnold, J Fung, J L Lanovaz
Balance control is essential for safe walking. Adding haptic input through light touch may improve walking balance; however, evidence is limited. This research investigated the effect of added haptic input through light touch in healthy young adults during challenging walking conditions. Sixteen individuals walked normally, in tandem, and on a compliant, low-lying balance beam with and without light touch on a railing. Three-dimensional kinematic data were captured to compute stride velocity (m/s), relative time spent in double support (%DS), a medial-lateral margin of stability (MOSML) and its variance (MOSMLCV), as well as a symmetry index (SI) for the MOSML...
December 2017: Heliyon
https://www.readbyqxmd.com/read/29321341/exercise-tolerance-and-balance-of-inspiratory-to-expiratory-muscle-strength-in-relation-to-breathing-timing-in-patients-with-chronic-obstructive-pulmonary-disease
#9
Keisuke Miki, Kazuyuki Tsujino, Tatsuya Edahiro, Seigo Kitada, Mari Miki, Kenji Yoshimura, Hiroyuki Kagawa, Yohei Oshitani, Yuko Ohara, Yuki Hosono, Hiroyuki Kurebe, Ryoji Maekura
Little is known about the applicability of respiratory muscle training based on exertional pathophysiological conditions in patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the relationship between breathing timing and exertional responses, as well as whether exertional changes in the inspiratory duty cycle (inspiratory time [Ti]/total time [Ttot]) affect pathophysiological conditions, including respiratory muscles. Methods: Forty-five stable COPD patients (mean age: 71...
January 11, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29317222/do-performance-measures-of-strength-balance-and-mobility-predict-quality-of-life-and-community-reintegration-after-stroke
#10
Joshua W Cohen, Tanya D Ivanova, Brenda Brouwer, Kimberly J Miller, Dianne Bryant, S Jayne Garland
OBJECTIVE: To investigate the extent to which physical performance measures of strength, balance and mobility taken at discharge from inpatient stroke rehabilitation can predict health-related quality of life (HRQoL) and community reintegration after 6 months. DESIGN: Longitudinal Study SETTING: University Laboratory PARTICIPANTS: Seventy-five adults recruited within one month following discharge home from inpatient stroke rehabilitation. Inclusion criteria were: major unilateral hemispheric stroke, English speaking, able to communicate, discharged home...
January 6, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29316888/the-preventive-effect-of-sensorimotor-and-vibration-exercises-on-the-onset-of-oxaliplatin-or-vinca-alkaloid-induced-peripheral-neuropathies-stop
#11
Fiona Streckmann, Maryam Balke, Helmar C Lehmann, Vanessa Rustler, Christina Koliamitra, Thomas Elter, Michael Hallek, Michael Leitzmann, Tilman Steinmetz, Petra Heinen, Freerk T Baumann, Wilhelm Bloch
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and clinically relevant side effect of chemotherapy. Approximately 50% of all leukemia, lymphoma, colorectal- and breast cancer patients are affected. CIPN is induced by neurotoxic chemotherapeutic agents and can manifest with sensory and/or motor deficits. It is associated with significant disability and poor recovery. Common symptoms include pain, altered sensation, reduced or absent reflexes, muscle weakness, reduced balance control and insecure gait...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29315031/osmolyte-adjustments-as-a-pressure-adaptation-in-deep-sea-chondrichthyan-fishes-an-intraspecific-test-in-arctic-skates-amblyraja-hyperborea-along-a-depth-gradient
#12
Paul H Yancey, Ben Speers-Roesch, Sheila Atchinson, James D Reist, Andrew R Majewski, Jason R Treberg
Accumulation of trimethylamine N-oxide (TMAO) by deep-sea animals is proposed to protect proteins against the destabilizing effects of high hydrostatic pressure (the piezolyte hypothesis). Chondrichthyan fishes (sharks, rays, and chimaeras) provide a unique test of this hypothesis because shallow-living species have elevated TMAO levels to counteract the destabilizing effects of high urea levels accumulated for osmoregulation. Limited interspecific studies of chondrichthyans reveal that increasing depth correlates with decreased urea and increased TMAO levels, suggesting a dynamic balance between destabilizing forces on proteins (high urea, hydrostatic pressure) and TMAO to counteract these forces...
March 2018: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/29314903/national-athletic-trainers-association-position-statement-prevention-of-anterior-cruciate-ligament-injury
#13
Darin A Padua, Lindsay J DiStefano, Timothy E Hewett, William E Garrett, Stephen W Marshall, Grace M Golden, Sandra J Shultz, Susan M Sigward
OBJECTIVE:   To provide certified athletic trainers, physicians, and other health care and fitness professionals with recommendations based on current evidence regarding the prevention of noncontact and indirect-contact anterior cruciate ligament (ACL) injuries in athletes and physically active individuals. BACKGROUND:   Preventing ACL injuries during sport and physical activity may dramatically decrease medical costs and long-term disability. Implementing ACL injury-prevention training programs may improve an individual's neuromuscular control and lower extremity biomechanics and thereby reduce the risk of injury...
January 9, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29314721/peritoneal-protein-losses-depend-on-more-than-just-peritoneal-dialysis-modality-and-peritoneal-membrane-transporter-status
#14
Suree Yoowannakul, Lauren S Harris, Andrew Davenport
Peritoneal protein clearance (PPCl) depends upon vascular supply and size selective permeability. Some previous reports suggested PPCl can distinguish fast peritoneal membrane transport due to local or systemic inflammation. However, as studies have been discordant, we wished to determine factors associated with an increased PPCl. Consecutive patients starting peritoneal dialysis (PD) who were peritonitis-free were studied. Data included a baseline peritoneal equilibration test (PET), measurement of dialysis adequacy, 24-h dialysate PPCl and body composition measured by multifrequency bioimpedance...
January 4, 2018: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29314199/bilateral-balanced-occlusion-compared-to-other-occlusal-schemes-in-complete-dentures-a-systematic-review
#15
REVIEW
C A A Lemos, F R Verri, J M L Gomes, J F Santiago Júnior, S L D Moraes, E P Pellizzer
No consensus has been reached regarding the best occlusal scheme for making complete dentures. Thus, the purpose of this systematic review was to compare bilateral balanced occlusion (BBO) with other occlusal schemes (canine guidance, lingualized occlusion, and zero degree) in complete dentures. The schemes were compared in terms of quality of life/satisfaction and masticatory performance. Two independent reviewers performed a comprehensive search of studies published in or before October 2017 using the PubMed/MEDLINE, Scopus, and Cochrane Library databases...
January 4, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29313071/glucocorticoids-inflammation-and-bone
#16
REVIEW
Melek Güler-Yüksel, Jos N Hoes, Irene E M Bultink, Willem F Lems
The current review on glucocorticoids (GCs), inflammation and bone is focused on three aspects: (1) the mutual effects between GCs, inflammation and bone in inflammatory rheumatic diseases, (2) current views on fracture risk assessment in patients using GCs and (3) non-pharmacological and pharmacological treatment to prevent fractures in GC-using patients with inflammatory rheumatic diseases. The use of GCs results in increased risk for fractures due to both direct and indirect negative effects of GCs on bone mass, and on bone and muscle strength...
January 8, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29311614/closed-loop-control-of-trunk-posture-improves-locomotion-through-the-regulation-of-leg-proprioceptive-feedback-after-spinal-cord-injury
#17
Eduardo Martin Moraud, Joachim von Zitzewitz, Jenifer Miehlbradt, Sophie Wurth, Emanuele Formento, Jack DiGiovanna, Marco Capogrosso, Grégoire Courtine, Silvestro Micera
After spinal cord injury (SCI), sensory feedback circuits critically contribute to leg motor execution. Compelled by the importance to engage these circuits during gait rehabilitation, assistive robotics and training protocols have primarily focused on guiding leg movements to reinforce sensory feedback. Despite the importance of trunk postural dynamics on gait and balance, trunk assistance has comparatively received little attention. Typically, trunk movements are either constrained within bodyweight support systems, or manually adjusted by therapists...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29306925/calcium-sensitization-mechanisms-in-detrusor-smooth-muscles
#18
REVIEW
Irfan Anjum
The contraction of detrusor smooth muscles depends on the increase in intracellular calcium. The influx of calcium from the plasma membrane calcium channels and calcium release from the sarcoplasmic reticulum give rise to intracellular calcium. Under the pathophysiological conditions, the increased sensitivity of regulatory and contractile proteins to calcium also plays an important role in maintaining the spontaneous detrusor smooth muscle activity. Many proteins have been identified to play a role in calcium sensitization...
January 8, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29306146/reactive-balance-control-in-older-adults-with-diabetes
#19
Pei-Yun Lee, Yi-Ju Tsai, Yu-Ting Liao, Yi-Ching Yang, Fen-Hwa Lu, Sang-I Lin
Diabetes mellitus is a major health problem for older adults worldwide and could be associated with impaired ability to recover balance after postural disturbances. This study compared reactive balance control in three groups of adults, young (YA), healthy non-diabetes older (nonDM-OA) and diabetes older (DM-OA). Twenty participants in each group completed a series of vision, plantar cutaneous sensitivity, grip power and lower limb strength tests. In the reactive balance test, participants stood on a force platform and used the dominant hand to pull the handle of a cord that could be suddenly released to create an imbalancing force...
December 30, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29305618/control-of-vertical-posture-while-standing-on-a-sliding-board-and-pushing-an-object
#20
Yun-Ju Lee, Bing Chen, Jing-Nong Liang, Alexander S Aruin
Voluntary pushing or translation perturbation of the support surface each induces a body perturbation that affects postural control. The objective of the study was to investigate anticipatory (APA) and compensatory (CPA) postural adjustments when pushing an object (that induces self-initiated perturbation) and standing on a sliding board (that induces translational perturbation). Thirteen healthy young participants were instructed to push a handle with both hands while standing on a sliding board that was either free to move in the anterior-posterior direction or stationary...
January 5, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
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