keyword
MENU ▼
Read by QxMD icon Read
search

oxytocin postpartum depression

keyword
https://www.readbyqxmd.com/read/28950923/adverse-life-events-psychiatric-history-and-biological-predictors-of-postpartum-depression-in-an-ethnically-diverse-sample-of-postpartum-women
#1
J Guintivano, P F Sullivan, A M Stuebe, T Penders, J Thorp, D R Rubinow, S Meltzer-Brody
BACKGROUND: Race, psychiatric history, and adverse life events have all been independently associated with postpartum depression (PPD). However, the role these play together in Black and Latina women remains inadequately studied. Therefore, we performed a case-control study of PPD, including comprehensive assessments of symptoms and biomarkers, while examining the effects of genetic ancestry. METHODS: We recruited our sample (549 cases, 968 controls) at 6 weeks postpartum from obstetrical clinics in North Carolina...
September 27, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28945961/postpartum-lactation-mediated-behavioral-outcomes-and-drug-responses-in-a-spontaneous-mouse-model-of-obsessive-compulsive-disorder
#2
Swarup Mitra, McKenzie Mucha, Savanah Owen, Abel Bult-Ito
Using a spontaneous mouse model of obsessive-compulsive disorder (OCD), the current study evaluated the influence of postpartum lactation on the expression of compulsive-like behaviors, SSRI effectiveness, and the putative role of oxytocin and dopamine in mediating these lactation specific behavioral outcomes. Compulsive-like lactating mice were less compulsive-like in nest building and marble burying and showed enhanced responsiveness to fluoxetine (50 mg/kg) in comparison to compulsive-like nonlactating and nulliparous females...
October 5, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28918249/perinatal-depression-and-dna-methylation-of-oxytocin-related-genes-a-study-of-mothers-and-their-children
#3
Leonora King, Stephanie Robins, Gang Chen, Volodymyr Yerko, Yi Zhou, Corina Nagy, Nancy Feeley, Ian Gold, Barbara Hayton, Gustavo Turecki, Phyllis Zelkowitz
The present study investigated the association of perinatal depression (PD) with differential methylation of 3 genomic regions among mother and child dyads: exon 3 within the oxytocin receptor (OXTR) gene and 2 intergenic regions (IGR) between the oxytocin (OXT) and vasopressin (AVP) genes. Maternal PD was assessed at 5 time-points during pregnancy and postpartum. Four groups were established based on Edinburgh Postnatal Depression Scale (EPDS) cut-off scores: no PD, prenatal or postpartum depressive symptoms only and persistent PD (depressive symptoms both prenatally and postpartum)...
September 19, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28889022/injection-of-oxytocin-into-paraventricular-nucleus-reverses-depressive-like-behaviors-in-the-postpartum-depression-rat-model
#4
Tong Wang, Cuige Shi, Xiaoxiao Li, Pan Zhang, Bo Liu, Hao Wang, Yongjun Wang, Yutao Yang, Yan Wu, Hui Li, Zhi-Qing David Xu
Oxytocin (OXT) has been considered as a neuroregulator mediating social behaviors and stress-related disorders. Recent clinical studies suggest that OXT might also act as antidepressant in postpartum depression (PPD) patients, but the mechanism is still unknown. In the present study, we explored the effect of OXT in paraventricular nucleus (PVN) and possible signaling pathway involved in a PPD rat model induced by gestation restraint stress (GRS). PPD rats exhibited depressive-like behaviors with significantly longer immobility time, shorter climbing time, and lower sucrose consumption compared to the control rats...
January 15, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/28749705/associations-between-postpartum-depression-breastfeeding-and-oxytocin-levels-in-latina-mothers
#5
Sandraluz Lara-Cinisomo, Kathryn McKenney, Arianna Di Florio, Samantha Meltzer-Brody
BACKGROUND: Postpartum depression (PPD), often comorbid with anxiety, is the leading medical complication among new mothers. Latinas have elevated risk of PPD, which has been associated with early breastfeeding cessation. Lower plasma oxytocin (OT) levels have also been associated with PPD in non-Latinas. This pilot study explores associations between PPD, anxiety, breastfeeding, and OT in Latinas. MATERIALS AND METHODS: Thirty-four Latinas were enrolled during their third trimester of pregnancy and followed through 8 weeks postpartum...
September 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28683833/effectiveness-of-skin-to-skin-contact-versus-care-as-usual-in-mothers-and-their-full-term-infants-study-protocol-for-a-parallel-group-randomized-controlled-trial
#6
Kelly H M Cooijmans, Roseriet Beijers, Anne C Rovers, Carolina de Weerth
BACKGROUND: Twenty-to-forty percent of women experience postpartum depressive symptoms, which can affect both the mother and infant. In preterm infants, daily skin-to-skin contact (SSC) between the mother and her infant has been shown to decrease maternal postpartum depressive symptoms. In full-term infants, only two studies investigated SSC effects on maternal depressive symptoms and found similar results. Research in preterm infants also showed that SSC improves other mental and physical health outcomes of the mother and the infant, and improves the quality of mother-infant relationship...
July 6, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28594092/understanding-the-relationship-between-cesarean-birth-and-stress-anxiety-and-depression-after-childbirth-a-nationwide-cohort-study
#7
Hung-Hui Chen, Jerry Cheng-Yen Lai, Shyh-Jou Hwang, Nicole Huang, Yiing-Jenq Chou, Li-Yin Chien
BACKGROUND: Women who undergo cesarean birth might have an increased risk for poor mental health after childbirth, possibly because of maternal and neonatal physical problems, low parental confidence, and decreased levels of oxytocin. However, this relationship remains controversial and requires further examination. The study aimed to examine the effect of cesarean birth on postpartum stress, anxiety, and depression. METHODS: This nationwide population-based cohort study was conducted using the Taiwan National Health Insurance Database...
June 8, 2017: Birth
https://www.readbyqxmd.com/read/28435979/oxytocin-system-in-neuropsychiatric-disorders-old-concept-new-insights
#8
Afzal Misrani, Sidra Tabassum, Cheng Long
Oxytocin (OXT) is a neuropeptide that plays a pivotal role among species peripherally and centrally. It recently has attracted much attention for its involvement in anxiety-related behavior, stress regulation, social behavior and various neuropsychiatric disorders. OXT is one of the important mediators of emotional and social behaviors such as maternal behavior, fear extinction, social support, happiness, and trust. It is also involved in learning and memory process. The recent progresses in OXT system have put this neuropeptide as an important psychotherapeutic intervention for various psychiatric disorders such as stress, anxiety disorders, social phobia, postpartum depression, bipolar disorder, autism, and schizophrenia...
April 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28431269/oxytocin-in-the-postnatal-period-associations-with-attachment-and-maternal-caregiving
#9
Jane Kohlhoff, Valsamma Eapen, Mark Dadds, Feroza Khan, Derrick Silove, Bryanne Barnett
BACKGROUND: This study investigated the associations of maternal oxytocin, self-reported attachment insecurity and depressive symptoms with maternal caregiving sensitivity at 3-4months postpartum, observed during the 'free play' and 'reunion' episodes of the Still Face Procedure. METHODS: 112 mothers completed questionnaires and gave blood samples to determine oxytocin plasma levels before (time 1) and after participating in the Still Face Procedure with their infant (time 2)...
July 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28193868/dopamine-in-the-medial-amygdala-network-mediates-human-bonding
#10
Shir Atzil, Alexandra Touroutoglou, Tali Rudy, Stephanie Salcedo, Ruth Feldman, Jacob M Hooker, Bradford C Dickerson, Ciprian Catana, Lisa Feldman Barrett
Research in humans and nonhuman animals indicates that social affiliation, and particularly maternal bonding, depends on reward circuitry. Although numerous mechanistic studies in rodents demonstrated that maternal bonding depends on striatal dopamine transmission, the neurochemistry supporting maternal behavior in humans has not been described so far. In this study, we tested the role of central dopamine in human bonding. We applied a combined functional MRI-PET scanner to simultaneously probe mothers' dopamine responses to their infants and the connectivity between the nucleus accumbens (NAcc), the amygdala, and the medial prefrontal cortex (mPFC), which form an intrinsic network (referred to as the "medial amygdala network") that supports social functioning...
February 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28133901/association-of-peripartum-synthetic-oxytocin-administration-and-depressive-and-anxiety-disorders-within-the-first-postpartum-year
#11
Aimee R Kroll-Desrosiers, Benjamin C Nephew, Jessica A Babb, Yurima Guilarte-Walker, Tiffany A Moore Simas, Kristina M Deligiannidis
BACKGROUND: Due to its potent effects on social behavior, including maternal behavior, oxytocin has been identified as a potential mediator of postpartum depression and anxiety. The objective of this study was to examine the relationship between peripartum synthetic oxytocin administration and the development of depressive and anxiety disorders within the first year postpartum. We hypothesized that women exposed to peripartum synthetic oxytocin would have a reduced risk of postpartum depressive and anxiety disorders compared with those without any exposure...
February 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28103103/oxytocin-mediates-a-calming-effect-on-postpartum-mood-in-primiparous-mothers
#12
Risa Niwayama, Shota Nishitani, Tsunehiko Takamura, Kazuyuki Shinohara, Sumihisa Honda, Tsunetake Miyamura, Yuko Nakao, Kazuyo Oishi, Miyuki Araki-Nagahashi
OBJECTIVES: The current study sought to characterize changes in salivary oxytocin (OT) secretion patterns across the breastfeeding cycle, and to evaluate whether breastfeeding has a positive effect on mood disturbances related to postpartum depression, via endogenous OT release. MATERIALS AND METHODS: Twenty-four primiparous mothers who delivered vaginally at term and were exclusively breastfeeding were examined 4-5 days postpartum. Salivary OT was measured using enzyme immunoassays at 30 minutes before breastfeeding (baseline), during breastfeeding (feeding), and 30 minutes after completing breastfeeding (postfeeding)...
March 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28050900/planned-early-birth-versus-expectant-management-waiting-for-prelabour-rupture-of-membranes-at-term-37-weeks-or-more
#13
REVIEW
Philippa Middleton, Emily Shepherd, Vicki Flenady, Rosemary D McBain, Caroline A Crowther
BACKGROUND: Prelabour rupture of membranes (PROM) at term is managed expectantly or by planned early birth. It is not clear if waiting for birth to occur spontaneously is better than intervening, e.g. by inducing labour. OBJECTIVES: The objective of this review is to assess the effects of planned early birth (immediate intervention or intervention within 24 hours) when compared with expectant management (no planned intervention within 24 hours) for women with term PROM on maternal, fetal and neonatal outcomes...
January 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28027955/oxytocin-pathways-in-the-intergenerational-transmission-of-maternal-early-life-stress
#14
REVIEW
Philipp Toepfer, Christine Heim, Sonja Entringer, Elisabeth Binder, Pathik Wadhwa, Claudia Buss
Severe stress in early life, such as childhood abuse and neglect, constitutes a major risk factor in the etiology of psychiatric disorders and somatic diseases. Importantly, these long-term effects may impact the next generation. The intergenerational transmission of maternal early life stress (ELS) may occur via pre-and postnatal pathways, such as alterations in maternal-fetal-placental stress physiology, maternal depression during pregnancy and postpartum, as well as impaired mother-offspring interactions...
February 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27870443/sex-differences-in-depression-during-pregnancy-and-the-postpartum-period
#15
REVIEW
Inger Sundström Poromaa, Erika Comasco, Marios K Georgakis, Alkistis Skalkidou
Women have a lifetime risk of major depression double that of men but only during their reproductive years. This sex difference has been attributed partially to activational effects of female sex steroids and also to the burdens of pregnancy, childbirth, and parenting. Men, in contrast, have a reproductive period difficult to delineate, and research on the mental health of men has rarely considered the effects of fatherhood. However, the couple goes through a number of potentially stressing events during the reproductive period, and both mothers and fathers are at risk of developing peripartum depression...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27320943/oxytocin-course-over-pregnancy-and-postpartum-period-and-the-association-with-postpartum-depressive-symptoms
#16
Andrea Jobst, Daniela Krause, Carina Maiwald, Kristin Härtl, Aye-Mu Myint, Ralph Kästner, Michael Obermeier, Frank Padberg, Benedikt Brücklmeier, Elif Weidinger, Susann Kieper, Markus Schwarz, Peter Zill, Norbert Müller
During the postpartum period, women are at higher risk of developing a mental disorder such as postpartum depression (PPD), a disorder that associates with mother-infant bonding and child development. Oxytocin is considered to play a key role in mother-infant bonding and social interactions and altered oxytocin plasma concentrations were found to be associated with PPD. In the present study, we evaluated oxytocin plasma levels and depressive symptoms during pregnancy and the postpartum period in healthy women...
August 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27312097/-oxytocin-and-postpartum-depression
#17
REVIEW
C Cardaillac, C Rua, E G Simon, W El-Hage
INTRODUCTION: Postpartum depression (PPD) is prevalent (about 10%) with a major impact on the mother and child health. At the hormonal level, poor regulation of oxytocin rate has a key role in depression. Recently, oxytocin has been used on psychiatric therapy, intranasal or intravenously, particularly in mood disorders. But, in obstetrics, this molecule is administered during childbirth. The objective of this study was to determine if intravenous administration of oxytocin could influence thymic state of the mother in the postpartum period...
October 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/27295067/oxytocin-and-depression-in-the-perinatal-period-a-systematic-review
#18
REVIEW
Diana Moura, Maria Cristina Canavarro, Margarida Figueiredo-Braga
Postpartum depression (PPD) is the most common postnatal psychiatric disorder, and it represents a considerable problem to the health and well-being of women and their families. Several pathogenic mechanisms have been identified in PPD, and recently, oxytocin (OT), known to be involved in childbirth and lactation, has drawn attention as a possible diagnostic and therapeutic tool in this disorder. The aim of this review was to assess and summarize the current literature on the relationship between OT as a potential depressive biomarker and depression in the perinatal period...
August 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27184829/genetic-and-neuroendocrine-regulation-of-the-postpartum-brain
#19
REVIEW
Stephen C Gammie, Terri M Driessen, Changjiu Zhao, Michael C Saul, Brian E Eisinger
Changes in expression of hundreds of genes occur during the production and function of the maternal brain that support a wide range of processes. In this review, we synthesize findings from four microarray studies of different maternal brain regions and identify a core group of 700 maternal genes that show significant expression changes across multiple regions. With those maternal genes, we provide new insights into reward-related pathways (maternal bonding), postpartum depression, social behaviors, mental health disorders, and nervous system plasticity/developmental events...
July 2016: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/27108164/oxytocin-receptor-dna-methylation-in-postpartum-depression
#20
Mary Kimmel, Makena Clive, Fiona Gispen, Jerry Guintivano, Tori Brown, Olivia Cox, Matthias W Beckmann, Johannes Kornhuber, Peter A Fasching, Lauren M Osborne, Elisabeth Binder, Jennifer L Payne, Zachary Kaminsky
The oxytocin receptor (OXTR) is a key regulator of stress and anxiety and may be regulated by both psychosocial risk factors and gonadal hormones, making it an attractive candidate for study in postpartum depression (PPD). The objective of this study was to investigate both serum hormone and PPD specific DNA methylation variation in the OXTR. Illumina HM450 microarray data generated in a prospective PPD cohort identified significant associations (P=0.014) with PPD in an intronic region in the OXTR located 4bp proximal to an estrogen receptor (ER) binding region...
July 2016: Psychoneuroendocrinology
keyword
keyword
109751
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"