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oxytocin postpartum depression

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https://www.readbyqxmd.com/read/28193868/dopamine-in-the-medial-amygdala-network-mediates-human-bonding
#1
Shir Atzil, Alexandra Touroutoglou, Tali Rudy, Stephanie Salcedo, Ruth Feldman, Jacob M Hooker, Bradford C Dickerson, Ciprian Catana, Lisa Feldman Barrett
Research in humans and nonhuman animals indicates that social affiliation, and particularly maternal bonding, depends on reward circuitry. Although numerous mechanistic studies in rodents demonstrated that maternal bonding depends on striatal dopamine transmission, the neurochemistry supporting maternal behavior in humans has not been described so far. In this study, we tested the role of central dopamine in human bonding. We applied a combined functional MRI-PET scanner to simultaneously probe mothers' dopamine responses to their infants and the connectivity between the nucleus accumbens (NAcc), the amygdala, and the medial prefrontal cortex (mPFC), which form an intrinsic network (referred to as the "medial amygdala network") that supports social functioning...
February 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28133901/association-of-peripartum-synthetic-oxytocin-administration-and-depressive-and-anxiety-disorders-within-the-first-postpartum-year
#2
Aimee R Kroll-Desrosiers, Benjamin C Nephew, Jessica A Babb, Yurima Guilarte-Walker, Tiffany A Moore Simas, Kristina M Deligiannidis
BACKGROUND: Due to its potent effects on social behavior, including maternal behavior, oxytocin has been identified as a potential mediator of postpartum depression and anxiety. The objective of this study was to examine the relationship between peripartum synthetic oxytocin administration and the development of depressive and anxiety disorders within the first year postpartum. We hypothesized that women exposed to peripartum synthetic oxytocin would have a reduced risk of postpartum depressive and anxiety disorders compared with those without any exposure...
February 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28103103/oxytocin-mediates-a-calming-effect-on-postpartum-mood-in-primiparous-mothers
#3
Risa Niwayama, Shota Nishitani, Tsunehiko Takamura, Kazuyuki Shinohara, Sumihisa Honda, Tsunetake Miyamura, Yuko Nakao, Kazuyo Oishi, Miyuki Araki-Nagahashi
OBJECTIVES: The current study sought to characterize changes in salivary oxytocin (OT) secretion patterns across the breastfeeding cycle, and to evaluate whether breastfeeding has a positive effect on mood disturbances related to postpartum depression, via endogenous OT release. MATERIALS AND METHODS: Twenty-four primiparous mothers who delivered vaginally at term and were exclusively breastfeeding were examined 4-5 days postpartum. Salivary OT was measured using enzyme immunoassays at 30 minutes before breastfeeding (baseline), during breastfeeding (feeding), and 30 minutes after completing breastfeeding (postfeeding)...
March 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28050900/planned-early-birth-versus-expectant-management-waiting-for-prelabour-rupture-of-membranes-at-term-37-weeks-or-more
#4
REVIEW
Philippa Middleton, Emily Shepherd, Vicki Flenady, Rosemary D McBain, Caroline A Crowther
BACKGROUND: Prelabour rupture of membranes (PROM) at term is managed expectantly or by planned early birth. It is not clear if waiting for birth to occur spontaneously is better than intervening, e.g. by inducing labour. OBJECTIVES: The objective of this review is to assess the effects of planned early birth (immediate intervention or intervention within 24 hours) when compared with expectant management (no planned intervention within 24 hours) for women with term PROM on maternal, fetal and neonatal outcomes...
January 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28027955/oxytocin-pathways-in-the-intergenerational-transmission-of-maternal-early-life-stress
#5
REVIEW
Philipp Toepfer, Christine Heim, Sonja Entringer, Elisabeth Binder, Pathik Wadhwa, Claudia Buss
Severe stress in early life, such as childhood abuse and neglect, constitutes a major risk factor in the etiology of psychiatric disorders and somatic diseases. Importantly, these long-term effects may impact the next generation. The intergenerational transmission of maternal early life stress (ELS) may occur via pre-and postnatal pathways, such as alterations in maternal-fetal-placental stress physiology, maternal depression during pregnancy and postpartum, as well as impaired mother-offspring interactions...
February 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27870443/sex-differences-in-depression-during-pregnancy-and-the-postpartum-period
#6
REVIEW
Inger Sundström Poromaa, Erika Comasco, Marios K Georgakis, Alkistis Skalkidou
Women have a lifetime risk of major depression double that of men but only during their reproductive years. This sex difference has been attributed partially to activational effects of female sex steroids and also to the burdens of pregnancy, childbirth, and parenting. Men, in contrast, have a reproductive period difficult to delineate, and research on the mental health of men has rarely considered the effects of fatherhood. However, the couple goes through a number of potentially stressing events during the reproductive period, and both mothers and fathers are at risk of developing peripartum depression...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27320943/oxytocin-course-over-pregnancy-and-postpartum-period-and-the-association-with-postpartum-depressive-symptoms
#7
Andrea Jobst, Daniela Krause, Carina Maiwald, Kristin Härtl, Aye-Mu Myint, Ralph Kästner, Michael Obermeier, Frank Padberg, Benedikt Brücklmeier, Elif Weidinger, Susann Kieper, Markus Schwarz, Peter Zill, Norbert Müller
During the postpartum period, women are at higher risk of developing a mental disorder such as postpartum depression (PPD), a disorder that associates with mother-infant bonding and child development. Oxytocin is considered to play a key role in mother-infant bonding and social interactions and altered oxytocin plasma concentrations were found to be associated with PPD. In the present study, we evaluated oxytocin plasma levels and depressive symptoms during pregnancy and the postpartum period in healthy women...
August 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27312097/-oxytocin-and-postpartum-depression
#8
REVIEW
C Cardaillac, C Rua, E G Simon, W El-Hage
INTRODUCTION: Postpartum depression (PPD) is prevalent (about 10%) with a major impact on the mother and child health. At the hormonal level, poor regulation of oxytocin rate has a key role in depression. Recently, oxytocin has been used on psychiatric therapy, intranasal or intravenously, particularly in mood disorders. But, in obstetrics, this molecule is administered during childbirth. The objective of this study was to determine if intravenous administration of oxytocin could influence thymic state of the mother in the postpartum period...
October 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/27295067/oxytocin-and-depression-in-the-perinatal-period-a-systematic-review
#9
REVIEW
Diana Moura, Maria Cristina Canavarro, Margarida Figueiredo-Braga
Postpartum depression (PPD) is the most common postnatal psychiatric disorder, and it represents a considerable problem to the health and well-being of women and their families. Several pathogenic mechanisms have been identified in PPD, and recently, oxytocin (OT), known to be involved in childbirth and lactation, has drawn attention as a possible diagnostic and therapeutic tool in this disorder. The aim of this review was to assess and summarize the current literature on the relationship between OT as a potential depressive biomarker and depression in the perinatal period...
August 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27184829/genetic-and-neuroendocrine-regulation-of-the-postpartum-brain
#10
REVIEW
Stephen C Gammie, Terri M Driessen, Changjiu Zhao, Michael C Saul, Brian E Eisinger
Changes in expression of hundreds of genes occur during the production and function of the maternal brain that support a wide range of processes. In this review, we synthesize findings from four microarray studies of different maternal brain regions and identify a core group of 700 maternal genes that show significant expression changes across multiple regions. With those maternal genes, we provide new insights into reward-related pathways (maternal bonding), postpartum depression, social behaviors, mental health disorders, and nervous system plasticity/developmental events...
July 2016: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/27108164/oxytocin-receptor-dna-methylation-in-postpartum-depression
#11
Mary Kimmel, Makena Clive, Fiona Gispen, Jerry Guintivano, Tori Brown, Olivia Cox, Matthias W Beckmann, Johannes Kornhuber, Peter A Fasching, Lauren M Osborne, Elisabeth Binder, Jennifer L Payne, Zachary Kaminsky
The oxytocin receptor (OXTR) is a key regulator of stress and anxiety and may be regulated by both psychosocial risk factors and gonadal hormones, making it an attractive candidate for study in postpartum depression (PPD). The objective of this study was to investigate both serum hormone and PPD specific DNA methylation variation in the OXTR. Illumina HM450 microarray data generated in a prospective PPD cohort identified significant associations (P=0.014) with PPD in an intronic region in the OXTR located 4bp proximal to an estrogen receptor (ER) binding region...
July 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27107296/maternal-adversities-during-pregnancy-and-cord-blood-oxytocin-receptor-oxtr-dna-methylation
#12
Eva Unternaehrer, Margarete Bolten, Irina Nast, Simon Staehli, Andrea H Meyer, Emma Dempster, Dirk H Hellhammer, Roselind Lieb, Gunther Meinlschmidt
The aim of this study was to investigate whether maternal adversities and cortisol levels during pregnancy predict cord blood DNA methylation of the oxytocin receptor (OXTR). We collected cord blood of 39 babies born to mothers participating in a cross-sectional study (N = 100) conducted in Basel, Switzerland (2007-10). Mothers completed the Inventory of Life Events (second trimester: T2), the Edinburgh Postnatal Depression Scale (EPDS, third trimester: T3), the Trier Inventory of Chronic Stress (TICS-K, 1-3 weeks postpartum) and provided saliva samples (T2, T3) for maternal cortisol profiles, as computed by the area under the curve with respect to ground (AUCg) or increase (AUCi) for the cortisol awakening response (CAR) and for diurnal cortisol profiles (DAY)...
September 2016: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/27052823/a-biopsychosocial-conceptual-framework-of-postpartum-depression-risk-in-immigrant-and-u-s-born-latina-mothers-in-the-united-states
#13
Sandraluz Lara-Cinisomo, Susan S Girdler, Karen Grewen, Samantha Meltzer-Brody
OBJECTIVE: In this review, we offer a conceptual framework that identifies risk factors of postpartum depression (PPD) in immigrant and U.S.-born Latinas in the United States by focusing on psychosocial and neuroendocrine factors. Although the evidence of the impact psychosocial stressors have on the development of PPD has been well-documented, less is known about the biological etiology of PPD or how these complex stressors jointly increase the risk of PPD in immigrant and U.S.-born Latinas in the United States...
May 2016: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/26957508/interaction-of-oxytocin-level-and-past-depression-may-predict-postpartum-depressive-symptom-severity
#14
Suena H Massey, Stephanie A Schuette, Hossein Pournajafi-Nazarloo, Katherine L Wisner, C Sue Carter
We examined plasma oxytocin concentration and postpartum depression (PPD) symptom severity in women who were not depressed during pregnancy and whether this differed by major depressive disorder (MDD) history. We assessed psychiatric history and plasma oxytocin in 66 healthy pregnant women in the third trimester (M = 35 ± 3 weeks) and depressive symptoms at 6 weeks postpartum (M = 5.9 ± 0.8 weeks). Linear regression analysis was used to examine oxytocin and PPD symptom severity and moderation of oxytocin and PPD by past MDD...
October 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/26857197/sleep-duration-depression-and-oxytocinergic-genotype-influence-prepulse-inhibition-of-the-startle-reflex-in-postpartum-women
#15
Erika Comasco, Maria Gulinello, Charlotte Hellgren, Alkistis Skalkidou, Sara Sylven, Inger Sundström-Poromaa
The postpartum period is characterized by a post-withdrawal hormonal status, sleep deprivation, and susceptibility to affective disorders. Postpartum mothering involves automatic and attentional processes to screen out new external as well as internal stimuli. The present study investigated sensorimotor gating in relation to sleep duration, depression, as well as catecholaminergic and oxytocinergic genotypes in postpartum women. Prepulse inhibition (PPI) of the startle reflex and startle reactivity were assessed two months postpartum in 141 healthy and 29 depressed women...
April 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/26574573/inflammatory-and-epigenetic-pathways-for-perinatal-depression
#16
Lindsey Garfield, Herbert L Mathews, Linda Witek Janusek
Depression during the perinatal period is common and can have adverse consequences for women and their children. Yet, the biobehavioral mechanisms underlying perinatal depression are not known. Adverse early life experiences increase the risk for adult depression. One potential mechanism by which this increased risk occurs is epigenetic embedding of inflammatory pathways. The purpose of this article is to propose a conceptual model that explicates the linkage between early life adversity and the risk for maternal depression...
May 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/26554749/intrapartum-synthetic-oxytocin-and-its-effects-on-maternal-well-being-at-2-months-postpartum
#17
Vivian Gu, Nancy Feeley, Ian Gold, Barbara Hayton, Stephanie Robins, Anna Mackinnon, Simcha Samuel, C Sue Carter, Phyllis Zelkowitz
BACKGROUND: Synthetic oxytocin (synOT) is commonly used in labor management to induce and augment labor, and to prevent postpartum hemorrhage. However, its long-term consequences for maternal health and behavior are largely understudied. We examined the relationship between synOT and maternal oxytocin levels, breastfeeding, and maternal mental health at 2 months postpartum. METHODS: Women were recruited during pregnancy or within 48 hours of giving birth through obstetric practices and hospitals...
March 2016: Birth
https://www.readbyqxmd.com/read/26257770/interaction-between-oxytocin-receptor-dna-methylation-and-genotype-is-associated-with-risk-of-postpartum-depression-in-women-without-depression-in-pregnancy
#18
Aleeca F Bell, C S Carter, Colin D Steer, Jean Golding, John M Davis, Alana D Steffen, Leah H Rubin, Travis S Lillard, Steven P Gregory, James C Harris, Jessica J Connelly
Postpartum depression (PPD) affects up to 19% of women, negatively impacting maternal and infant health. Reductions in plasma oxytocin levels have been associated with PPD and heritability studies have established a genetic contribution. Epigenetic regulation of the oxytocin receptor gene (OXTR) has been demonstrated and we hypothesized that individual epigenetic variability at OXTR may impact the development of PPD and that such variability may be central to predicting risk. This case-control study is nested within the Avon Longitudinal Study of Parents and Children and included 269 cases with PPD and 276 controls matched on age group, parity, and presence or absence of depressive symptoms in pregnancy as assessed by the Edinburgh Postnatal Depression Scale...
2015: Frontiers in Genetics
https://www.readbyqxmd.com/read/26130435/maternal-depression-and-child-oxytocin-response-moderation-by-maternal-oxytocin-and-relational-behavior
#19
Maayan Pratt, Yael Apter-Levi, Adam Vakart, Michal Feldman, Ruth Fishman, Tamar Feldman, Orna Zagoory-Sharon, Ruth Feldman
BACKGROUND: Maternal postpartum depression (PPD) carries long-term detrimental effects on children's well-being, yet the mechanisms of transmission remain unclear. One possible pathway of vulnerability involves the oxytocinergic (OT) system, which is transferred from mother to child via sensitive caregiving and is disrupted in PPD. METHOD: A large birth cohort (N = 1983) of women were repeatedly assessed for depression from birth to 6 years. Utilizing an extreme case design, two matched cohorts were formed; mothers chronically depressed from birth to 6 years and nondepressed controls (N = 97, depressed = 41, nondepressed; N = 56)...
September 2015: Depression and Anxiety
https://www.readbyqxmd.com/read/26112436/maternal-mental-health-moderates-the-relationship-between-oxytocin-and-interactive-behavior
#20
Simcha Samuel, Barbara Hayton, Ian Gold, Nancy Feeley, C Sue Carter, Phyllis Zelkowitz
Mothers with mood or anxiety disorders exhibit less optimal interactive behavior. The neuropeptide oxytocin (OT) has been linked to more optimal interactive behaviors in mothers without mental illness, and it may play a particularly beneficial role in mothers with mood or anxiety disorders given its antidepressant and anxiolytic functions. We compared the relationship between OT and interactive behavior in mothers with and without mental health problems. Participants included 20 women diagnosed with postpartum mood or anxiety disorders (clinical sample) and 90 women with low levels of depression and anxiety during pregnancy and postpartum (community sample)...
July 2015: Infant Mental Health Journal
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