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antibiótics stewardship

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https://www.readbyqxmd.com/read/28935515/template-for-an-antibiotic-stewardship-policy-for-post-acute-and%C3%A2-long-term-care-settings
#1
Robin L P Jump, Swati Gaur, Morgan J Katz, Christopher J Crnich, Ghinwa Dumyati, Muhammad S Ashraf, Elizabeth Frentzel, Steven J Schweon, Philip Sloane, David Nace
In response to a rising concern for multidrug resistance and Clostridium difficile infections, the Centers for Medicare and Medicaid services (CMS) will require all long-term care (LTC) facilities to establish an antibiotic stewardship program by November 2017. Thus far, limited evidence describes implementation of antibiotic stewardship in LTC facilities, mostly in academic- or hospital-affiliated settings. To support compliance with CMS requirements and aid facilities in establishing a stewardship program, the Infection Advisory Committee at AMDA-The Society for Post-Acute and Long-Term Care Medicine, has developed an antibiotic stewardship policy template tailored to the LTC setting...
September 18, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28932712/multidrug-and-co-resistance-patterns-of-non-fermenting-gram-negative-bacilli-involved-in-ventilator-associated-pneumonia-carrying-class-1-integron-in-the-north-of-iran
#2
Masoumeh Bagheri-Nesami, Mohammad Sadegh Rezai, Fatemeh Ahangarkani, Alireza Rafiei, Attieh Nikkhah, Gohar Eslami, Kheironesa Shafahi, Azin Hajalibeig, Rezvan Khajavi
INTRODUCTION: Ventilator-associated pneumonia (VAP) due to non-fermenting Gram-negative bacilli (NFGNB), especially Pseudomonas aeruginosa and Acinetobacter spp., is one of the main hospital-acquired infections leading to mortality and morbidity, especially in intensive care units (ICUs). This study seeks to determine the multidrug and co-resistance (MDR) patterns of NFGNB that are agents of VAP, and assess the presence of class 1 integron in these bacteria. METHODS: This cross-sectional study involved VAP patients admitted in the ICUs of 18 hospitals in the Mazandaran province, located in the North of Iran...
September 2017: Germs
https://www.readbyqxmd.com/read/28929815/the-challenge-of-curbing-aminoglycoside-resistance-can-antimicrobial-stewardship-programs-play-a-critical-role
#3
Vassiliki Pitiriga, Evangelia Dimitroulia, George Saroglou, Athanassios Tsakris
Aminoglycosides are useful antimicrobials, primarily for serious infections involving aerobic gram-negative pathogens. The inevitable increase in aminoglycoside resistance has led to calls for reducing levels of inappropriate aminoglycoside prescribing through the implementation of various antibiotic stewardship programs (ASPs). These programs mainly include restriction policies and aminoglycoside cycling. Although aminoglycoside resistance rates appear essential for measuring effectiveness of these interventions, most studies have focused on economic outcomes or clinical efficacy and toxicities...
September 20, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28927475/impact-of-discontinuing-contact-precautions-for-mrsa-and-esble-in-an-intensive-care-unit-a-prospective-noninferiority-before-and-after-study
#4
Laurie Renaudin, Mathieu Llorens, Christophe Goetz, Sébastien Gette, Vincente Citro, Sylvia Poulain, Marie-Laure Vanson, Jocelyne Sellies
OBJECTIVE To compare incidence densities of methicillin-resistant Staphylococcus aureus (MRSA) or extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBLE) acquisition in the intensive care unit (ICU) before and after discontinuation of contact precautions (CP) and application of standard precautions (SP). DESIGN Prospective noninferiority before-and-after study comparing 2 periods: January 1, 2012, to January 31, 2014 (the CP period) and February 1, 2014, to February 29, 2016 (the SP period). SETTING A 16-bed polyvalent ICU in France with only single-bed rooms with dedicated equipment and reusable medical devices...
September 20, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28923621/extended-spectrum-beta-lactamase-producing-enterobacteriaceae-related-urinary-tract-infection-in-kidney-transplant-recipients-risk-factors-treatment-and-long-term-outcome
#5
S Brakemeier, S I Taxeidi, B Zukunft, D Schmidt, J Gaedeke, M Dürr, S Hansen, K Budde
BACKGROUND: Prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) has risen in kidney transplant (KT) patients, with no long-term data so far on graft function or survival. METHODS: KT patients with ESBL-E-positive urine culture were retrospectively analyzed regarding initial adequate antimicrobial therapy, recurrent infection, transplant function, and survival compared with an ESBL-E-negative KT control cohort. RESULTS: ESBL-E-positive KT patients (n = 93) were older (55...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28914100/acute-myeloid-leukemia-and-the-infectious-diseases-consultant
#6
Victor Mulanovich, Dimitrios P Kontoyiannis
Infectious complications following treatment of acute myeloid leukemia (AML) are important causes of morbidity and mortality. The spectrum and complexity of these infections is reflected by the severe net state of immunosuppression of AML patients, that is dynamic and continuously changing, the polypharmacy, including the widespread use of anti-infectives and the complex epidemiology of severe and frequently resistant pathogens afflicting these patients. Infectious diseases (ID) consultants having a critical mass of expertise and intimate knowledge of the intricacies of leukemia care, add considerable value in improving outcomes of patients with AML who develop infections...
September 15, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28905709/antimicrobial-stewardship-in-laboratory-animal-facilities
#7
Heather L Narver
Bacterial resistance to antimicrobial drugs has become a global health crisis. Physicians and veterinarians are embracing the concept of 'antimicrobial stewardship' (AMS) to preserve the efficacy of antibiotics for future generations. Antimicrobials are used in laboratory animals to treat clinical disease, to protect populations that may be vulnerable to infection, and in research projects including studies of the microbiome and to influence expression in genetically engineered animals. This overview provides a critical look at the use of antimicrobials in contemporary vivaria, with special attention to rodents because they are the most commonly used species in research and because antimicrobial use in rodents is not straightforward...
January 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28903514/impact-of-an-antimicrobial-stewardship-program-on-antibiotic-use-at-a-nonfreestanding-children-s-hospital
#8
R Brigg Turner, Elena Valcarlos, Ann M Loeffler, Michael Gilbert, Dominic Chan
Background: Pediatric stewardship programs have been successful at reducing unnecessary antibiotic use. Data from nonfreestanding children's hospitals are currently limited. This study is an analysis of antibiotic use after implementation of an antimicrobial stewardship program at a community nonfreestanding children's hospital. Methods: In April 2013, an antimicrobial stewardship program that consisted of physician-group engagement and pharmacist prospective auditing and feedback was initiated...
September 1, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28900004/network-of-microbial-and-antibiotic-interactions-drive-colonization-and-infection-with-multidrug-resistant-organisms
#9
Joyce Wang, Betsy Foxman, Lona Mody, Evan S Snitkin
The emergence and spread of multidrug-resistant organisms (MDROs) across global healthcare networks poses a serious threat to hospitalized individuals. Strategies to limit the emergence and spread of MDROs include oversight to decrease selective pressure for MDROs by promoting appropriate antibiotic use via antibiotic stewardship programs. However, restricting the use of one antibiotic often requires a compensatory increase in the use of other antibiotics, which in turn selects for the emergence of different MDRO species...
September 12, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28893446/use-of-an-annual-art-competition-to-promote-web-site-traffic-and-engage-children-in-antimicrobial-stewardship-in-pennsylvania
#10
Nkuchia M M'ikanatha, Courtney Yealy, Anna-Marie Warrington, Tabitha Reefer, Sameh W Boktor, Natalie Mueller, Mary Leonard, Nicole M Hackman
We used Google Analytics to assess whether annual kids' art competitions changed traffic to a Web site on appropriate antibiotic use. We found that announcements about kids' art competitions correlated with increased traffic to the Web site, suggesting that this innovation has promise in promoting antimicrobial stewardship efforts.
September 8, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28892925/impact-of-antibiotic-stewardship-program-on-prescribing-pattern-of-antimicrobials-in-patients-of-medical-intensive-care-unit
#11
Nishal Shah, Anuradha Joshi, Barna Ganguly
INTRODUCTION: Rising concerns about antimicrobial resistance and inadequate development of effective new anti-infective drugs have stimulated universal efforts to strengthen infection-control interventions. Antimicrobial stewardship is a rational, systematic approach to promote the optimal selection, dosing, and duration of therapy for antimicrobial agents throughout the course of their use in order to improve the outcomes. AIM: Since in Shree Krishna Hospital (SKH), Antibiotic Stewardship Program (ASP) was first implemented in 2013, this study was planned to assess any change in antimicrobial use before and after implementation of ASP and to study the rate and pattern of antimicrobial use in medical ICU...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892282/diabetic-foot-infection-antibiotic-therapy-and-good-practice-recommendations
#12
Nicholas D Barwell, Marion C Devers, Brian Kennon, Helen E Hopkinson, Claire McDougall, Matthew J Young, Hannah M A Robertson, Duncan Stang, Stephanie J Dancer, Andrew Seaton, Graham P Leese
BACKGROUND: Healthcare events related to diabetic foot disease carry a burden of morbidity, mortality and economic cost. Prompt identification of clinical infection with appropriate tissue sampling limits use of broad spectrum empirical antibiotics and improves antibiotic stewardship. Staphylococcus aureus remains the commonest infecting organism and high-dose flucloxacillin remains the empirical antibiotic of choice for antibiotic naïve patients. Barriers to microbe-specific treatment include: adequate tissue sampling, delays in culture results, drug allergies and the emergence of multidrug-resistant organisms which can complicate the choice of targeted antibiotics...
September 11, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28887203/clinical-relevance-of-metronidazole-and-peripheral-neuropathy-a-systematic-review-of-the-literature
#13
REVIEW
Tiffany A Goolsby, Bernadette Jakeman, Robert P Gaynes
The objective of this paper was to review and evaluate the literature on metronidazole-associated peripheral neuropathy and determine the relevance in clinical practice. MEDLINE/PubMed, EBSCO, and Google Scholar were searched through February 2017 using the search terms metronidazole and peripheral neuropathy, or polyneuropathy, or paresthesia, or neurotoxicity. Relevant case reports, retrospective studies, surveys, and review articles were included. Bibliographies of all relevant articles were reviewed for additional sources...
September 5, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28887201/reactive-oxygen-therapy-a-novel-antimicrobial
#14
REVIEW
Matthew Dryden
The main solution to the global antibiotic resistance crisis is reducing the volume of antibiotic use in medicine, agriculture and the environment. However there is also a pressing need for novel antimicrobials. Despite much rhetoric, there are few entirely novel agents in development. One such therapy to reach clinical use is an agent using Reactive Oxygen Species (ROS), oxygen radicals, as an antimicrobial mechanism. ROS can be delivered to the site of infection in various formats. ROS is highly antimicrobial against Gram positive and negative bacteria, viruses and fungi...
September 5, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28886537/a-probabilistic-approach-to-assess-antibiotic-resistance-development-risks-in-environmental-compartments-and-its-application-to-an-intensive-aquaculture-production-scenario
#15
Andreu Rico, Rianne Jacobs, Paul J Van den Brink, Alfredo Tello
Estimating antibiotic pollution and antibiotic resistance development risks in environmental compartments is important to design management strategies that advance our stewardship of antibiotics. In this study we propose a modelling approach to estimate the risk of antibiotic resistance development in environmental compartments and demonstrate its application in aquaculture production systems. We modelled exposure concentrations for 12 antibiotics used in Vietnamese Pangasius catfish production using the ERA-AQUA model...
September 5, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28885937/utility-of-the-nanosphere-verigene-in-the-identification-of-bacteremia-isolates-from-the-burn-intensive-care-unit
#16
Aaron Farmer, Charlotte A Lanteri, Eric Steele, Katrin Mende, Jeremy Pamplin, Kevin S Akers
INTRODUCTION: The Nanosphere Verigene Blood Culture Nucleic Acid Tests allow pathogen and antimicrobial resistance marker identification within 2.5 hours of a positive blood culture. This study assessed the sensitivity of the Verigene among Burn Intensive Care Unit (BICU) isolates and acceleration to targeted antibiotic therapy. METHODS: Bacterial identifications from BICU patients with positive blood cultures over 8 months were compared using 2 different platforms, the Verigene Gram-positive and Gram-negative blood culture tests vs...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28885907/antibiotic-stewardship-why-we-must-how-we-can
#17
REVIEW
Arjun Srinivasan
Improving our antibiotic use is critical to the safety of our patients and the future of medicine. This can improve patient outcomes, save money, reduce resistance, and help prevent negative consequences such as Clostridium difficile infection. The US Centers for Disease Control and Prevention (CDC) is undertaking a nationwide effort to appropriately improve antibiotic use in inpatient and outpatient settings.
September 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28882763/antimicrobial-resistance-of-enterococcus-in-turkey-a-meta-analysis-of-current-studies
#18
Imdat Kilbas, Ihsan Hakki Ciftci
OBJECTIVES: This study conducted a meta-analysis of Enterococcus isolates collected in 2000-2015 in Turkey and their susceptibility and resistance to antibiotics, clinical indications for the initial drug treatment, and identification of alternative treatments. METHODS: This meta-analysis examined antibiotic susceptibility and resistance in Enterococcus. The study was planned and conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses...
September 4, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28882725/what-is-antimicrobial-stewardship
#19
REVIEW
Oliver J Dyar, Benedikt Huttner, Jeroen Schouten, Céline Pulcini
BACKGROUND: The use of the term "antimicrobial stewardship" (AMS) has grown exponentially in recent years, typically referring to programmes and interventions that aim to optimise antimicrobial use. Although AMS originated within human healthcare, it is increasingly applied in broader contexts including animal health and One Health. As the use of the term AMS becomes more common, it is important to consider what AMS is, as well as what it is not. AIMS: To review the emergence and evolution of the term "antimicrobial stewardship"...
September 4, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28882723/antibiotic-stewardship-update-and-perspectives
#20
EDITORIAL
Céline Pulcini
No abstract text is available yet for this article.
September 4, 2017: Clinical Microbiology and Infection
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