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Urinary human menopausal gonadotropin

Xiuxian Zhu, Jing Ye, Yonglun Fu, Ai Ai, Renfei Cai, Yun Wang, Qingging Hong, Tian Hui, Qifeng Lyu, Qiuju Chen, Yanping Kuang
Progestin-primed ovarian stimulation (PPOS) protocol has recently been demonstrated to be an novel regimen for preventing premature LH surges during controlled ovarian hyperstimulation (COH) in combination with frozen-thawed embryo transfer (FET). Our prospective controlled study was to explore the effect of human chorionic gonadotropin (hCG) contained in human menopausal gonadotropin (hMG) on the clinical outcomes in normalovulatory women undergoing COH with PPOS. A total of 180 patients were allocated into three groups according to the gonadotropin (Gn) used: group A (human menopausal gonadotropin, hMG-A), group B (hMG-B) or group C (follicle stimulating hormone, FSH)...
October 20, 2017: Oncotarget
María Cruz, Antonio Requena, David Agudo, Juan Antonio García-Velasco
BACKGROUND: The cumulus-oocyte complex plays a central role in the regulation of folliculogenesis where it is important for the maturation, reprogramming, and fertilization of oocytes. Consequently, cumulus cell gene expression profiling is being explored as a promising method for assessing oocyte competence in the near future. Through DNA microarray technology, we analyzed the potential differences in the gene expression profiles of cumulus cells from preovulatory follicles after controlled ovarian stimulation using different types of gonadotropins...
August 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Leila Pourali, Sedigheh Ayati, Shirin Tavakolizadeh, Hourieh Soleimani, Fatemeh Teimouri Sani
BACKGROUND: Clomiphene citrate is one of the effective drugs for infertility treatment due to oligo-ovulation or anovulation. Intrauterine insemination (IUI) is one of more adherent methods for treatment of infertile cases which is followed by controlled ovarian hyperstimulation (COH). OBJECTIVE: the aim of this study was to evaluate Clomiphene citrate versus letrozole with gonadotropins in IUI cycles. MATERIALS AND METHODS: In this prospective randomized trial, 180 infertile women who were referred to Milad Hospital were selected...
January 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
Tal Shavit, Mohammed Agdi, Weon Y Son, Josseph Hasson, Michael H Dahan
BACKGROUND: The aim of this study was to compare pregnancy rates and stimulation parameters in patients with diminished ovarian reserve, who were treated with recombinant human luteinizing hormone (r-LH) or menopausal gonadotropins (hMG), as part of a microdose flare protocol. METHODS: A retrospective cohort study was performed. Comparisons between the group that was stimulated with r-LH plus follicle stimulating hormone (FSH) to those treated with hMG and FSH, were performed...
August 2016: Minerva Ginecologica
Alessandro Pacchiarotti, Helmy Selman, Claudia Valeri, Simona Napoletano, Marco Sbracia, Gabriele Antonini, Giulio Biagiotti, Arianna Pacchiarotti
The Assisted Reproductive Technology (ART) was born in order to help couples with infertility issues in having a baby. The first treatments of IVF used the spontaneous cycle of the women, with the retrieval of only one oocyte. Further studies have shown that it is possible to induce ovulation by administrating gonadotropins during the menstrual cycle, in order to obtain a higher number of oocytes. Many stimulation protocols have been introduced for controlled ovarian hyperstimulation of patients undergoing in vitro fertilization treatment...
2016: Current Pharmaceutical Biotechnology
Antonio Requena, María Cruz, David Agudo, Alberto Pacheco, Juan Antonio García-Velasco
OBJECTIVE: To determine whether the type of gonadotropin affects the secretion of oocyte-specific factors, the endocrine pattern in follicular fluid, and the apoptosis rate in cumulus cells. STUDY DESIGN: Prospective and observational study into an university-affiliated private in vitro fertilization setting. Ninety women included in our oocyte donation program were stimulated with human menopausal gonadotropin (hMG), recombinant follicle-stimulating hormone (FSH) or urinary FSH...
February 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Martin Kathrins
MacLeod J, Pazianos A, Ray B. The restoration of human spermatogenesis and of the reproductive tract with urinary gonadotropins following hypophysectomy. Fertil Steril 1966;17(1):7-23. "No precedent was available in the male for the amount of [human menopausal gonadotropin] to be given in order to initiate spermatogenesis, if the latter could be done at all." "In this experiment, the evidence is strongly in favor of FSH activity being exerted first at the level of the spermatogonium, inducing mitosis and proliferation of this cell...
January 2016: Fertility and Sterility
Alberto Revelli, Grazia Pettinau, Gemma Basso, Andrea Carosso, Alessandro Ferrero, Cecilia Dallan, Stefano Canosa, Gianluca Gennarelli, Daniela Guidetti, Claudia Filippini, Chiara Benedetto
BACKGROUND: The association of recombinant FSH (rFSH) plus recombinant LH (rLH) is currently used for Controlled Ovarian Stimulation (COS) in human IVF, but its efficacy has, to date, not yet been compared to that of human Menopausal Gonadotropin (hMG), the FSH + LH activity-containing urinary drug. METHODS: Eight hundred forty-eight (848) IVF patients classified as expected "poor" or "normal" responders according to antral follicle count (AFC) and basal (day 3) FSH were treated with rFSH + rLH (2:1 ratio, n = 398, Group A) or hMG (n = 450, Group B)...
July 25, 2015: Reproductive Biology and Endocrinology: RB&E
Klaus Bühler
Gonadotropin treatment has been used in fertility treatment since the 1930s. First, preparations coming from animals were injected, then, gonadotropins prepared from the pituitary glands of human cadavers. A great step was achieved with the introduction of human menopausal gonadotropin extracted from the urine of postmenopausal women. When cases of Creutzfeld-Jacob disease were recognized after the use of human pituitary-derived hormone injections, urinary gonadotropins were increasingly purified and then produced by the use of recombinant DNA technology...
2015: Therapeutics and Clinical Risk Management
Rui Hua, Lan Ma, Hong Li
Purified human menopausal gonadotropin (HMG) is a natural product extracted from the urine of postmenopausal women that contains pituitary follicle-stimulating hormone (FSH), luteinizing hormone (LH), and a small amount of human chorionic gonadotropin (HCG). Here we retrospectively conducted a clinical pharmaceutical study on a cohort of normogonadotropic infertile patients addressed to long GnRH-agonist protocol with serum LH concentration ranging from 0.5 IU/L to 1.5 IU/L during the midfollicle phase, aiming at evaluating the effects of purified HMG supplementation during ovarian stimulation...
2013: International Journal of Reproductive Medicine
R Slopień, A Warenik-Szymankiewicz
Premature ovarian failure (POF), also known as primary ovarian insufficiency, is diagnosed in the event when primary or secondary amenorrhea and hypoestrogenism with high levels of gonadotropins occur in women before the age of 40. POF, caused by genetic, autoimmune and environmental factors, leads to a decrease in numbers of primordial follicles, accelerated atresia, and impaired follicular function. The diagnosis of POF is an indication for hormonal replacement therapy (HRT), which should be continued until the mean age of menopause in a given population...
2014: Clinical and Experimental Obstetrics & Gynecology
P E Levi Setti, C Alviggi, G L Colombo, C Pisanelli, C Ripellino, S Longobardi, P L Canonico, G De Placido
BACKGROUND: Gonadotropins are protein hormones which are central to the complex endocrine system that regulates normal growth, sexual development, and reproductive function. There is still a lively debate on which type of gonadotropin medication should be used, either human menopausal gonadotropin or recombinant follicle-stimulating hormone. The objective of the study was to perform a systematic review of the recent literature to compare recombinant follicle-stimulating hormone to human menopausal gonadotropin with the aim to assess any differences in terms of efficacy and to provide a cost evaluation based on findings of this systematic review...
May 2015: Journal of Endocrinological Investigation
Diego Ezcurra, Peter Humaidan
Gonadotropins extracted from the urine of post-menopausal women have traditionally been used to stimulate folliculogenesis in the treatment of infertility and in assisted reproductive technology (ART). Products, such as human menopausal gonadotropin (hMG), consist not only of a mixture of the hormones, follicle-stimulating hormone (FSH), luteinising hormone (LH) and human chorionic gonadotropin (hCG), but also other biologically active contaminants, such as growth factors, binding proteins and prion proteins...
October 3, 2014: Reproductive Biology and Endocrinology: RB&E
Soheila Akbari, Maryam Ayazi Roozbahani, Fatemeh Ayazi Roozbahani
BACKGROUND: Clomiphene citrate (CC) an agonist and antagonist of estrogen, is the first line treatment in ovarian stimulation. Anti-estrogenic effect of CC in endometrial thickness and cervical mucus has negative effect on pregnancy rate. Letrozole is an Aromatase Inhibitor has been seen that has acceptable pregnancy rate compared to CC. OBJECTIVE: The aim of this study was to compare the efficacy of letrozole and clomiphene citrate (CC) with gonadotropins for ovarian stimulation in women candidate for intrauterine insemination (IUI)...
January 2012: Iranian Journal of Reproductive Medicine
Enrico Papaleo, Carlo Alviggi, Giorgio Lorenzo Colombo, Claudio Pisanelli, Claudio Ripellino, Salvatore Longobardi, Pier Luigi Canonico
BACKGROUND: Hypogonadotropic hypogonadal women are characterized by ovarian functionality deficiency, caused by low concentrations of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). To recover reproduction functionality, recommended therapies for ovarian induction involve injections of FSH and LH medications. OBJECTIVE: Since important differences exist between recombinant and urinary gonadotropin therapies in terms of efficacy and cost, the objective of this study was to develop a cost-effectiveness model to compare recombinant FSH (rFSH) + recombinant LH (rLH) and highly purified human menopausal gonadotropin (HP-HMG)...
2014: Therapeutics and Clinical Risk Management
S Sahmay, T A Usta, G Zebitay, L M Senturk, E Oral, P Ocal, M Idil, T Irez
AIM: The aim of this study was to compare human menopausal gonadotropins with recombinant follicle stimulating hormone-follitropin alpha following a long down-regulation protocol in intra cytoplasmic sperm injection cycles in our clinic, and to review the outcomes in the light of preceding studies. METHODS: This was a retrospective study. Among a total number of 2798 patients who had undergone IVF/ICSI applications, 579 eligible patients were included, and their data were evaluated retrospectively...
August 2014: Minerva Ginecologica
Cui-Ling Lu, Tian-Ren Wang, Li-Ying Yan, Xi Xia, Xiao-Hui Zhu, Rong Li, Hong-Cui Zhao, Jie Yan, Tai-Lang Yin, Hong-Yan Jin, Yan Zhang, Wen-Xin Zhang, Huai-Liang Feng, Jie Qiao
Gonadotropins have been widely used in human-assisted reproduction and animal science for the past four decades. However, the effects of gonadotropins on oocyte maturation at the molecular and biochemical levels are poorly understood. To determine the effects of gonadotropins (recombinant follicle stimulating hormone and urinary human menopausal gonadotropin) on oocyte maturation, we used the bovine oocyte in vitro maturation model. First, we studied the effects of increasing gonadotropin concentrations on nuclear maturation and mitochondrial function in oocytes...
August 2014: Biology of Reproduction
Antonio Requena, María Cruz, Francisco J Ruiz, Juan A García-Velasco
BACKGROUND: Luteinizing hormone (LH) activity in human menopausal gonadotropin (hMG) preparations is derived from human chorionic gonadotropin (hCG) rather than LH. Therefore, we aimed to determine whether there are similarities in the endocrine and follicular profiles of serum and follicular fluid from controlled ovarian stimulation with the recombinant gonadotropins follicle-stimulating hormone plus luteinizing hormone (rFSH + rLH) or highly purified human menopausal gonadotropin (HP-hMG)...
2014: Reproductive Biology and Endocrinology: RB&E
Hong Ye, Guo-ning Huang, Yun-xia Cao, Ying Zhong, Yuan-hua Huang, Gui-jin Zhu, Li-ming Zhou, Zi-jiang Chen, Juan-zi Shi, Yong Zeng, Ning Weng, Xue-feng Huang, Jing Yang, Yi-min Zhu, Yan-ping Li, Dong Yi, Guang-lun Zhuang
OBJECTIVE: To investigate the effect of domestic urine-derived high-purity follicle- stimulating hormone (HP-FSH, Lishenbao) on the outcome of in vitro fertilization(IVF) embryo transfer (ET) in controlled ovarian stimulation (COS). METHODS: From 1 September 2010 to 31 March 2011, total of 3178 infertility patients from 14 Reproductive Center with IVF or intracytoplasmic sperm injection (ICSI) indications who accepted first IVF or ICSI cycle were studied retrospectively...
November 2013: Zhonghua Fu Chan Ke za Zhi
Francisco M Moran, Jiangang Chen, Nancy A Gee, Pete N Lohstroh, Bill L Lasley
OBJECTIVE: We propose that the adrenal gland of an older higher primate female animal model will respond to human chorionic gonadotropin (hCG) hormone challenge by secreting additional dehydroepiandrosterone sulfate (DHEAS). Such a response in surgically and chemically castrated animals will provide proof of concept and a validated animal model for future studies to explore the rise in DHEAS during the menopausal transition of women. METHODS: Twenty-four 18- to 26-year-old female cynomolgus monkeys were screened for ovarian function and then either ovariectomized (n = 4) or treated with a gonadotropin-releasing hormone agonist (GnRHa; n = 20) to block ovarian steroid production...
March 2013: Menopause: the Journal of the North American Menopause Society
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