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Relasping remitting multiple sclerosis

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https://www.readbyqxmd.com/read/29746722/pharmacometric-analysis-of-the-relationship-between-absolute-lymphocyte-count-and-expanded-disability-status-scale-and-relapse-rate-efficacy-end-points-in-multiple-sclerosis-trials
#1
A M Novakovic, A Thorsted, E Schindler, S J├Ânsson, A Munafo, M O Karlsson
The aim of this work was to assess the relationship between the absolute lymphocyte count (ALC), and disability (as measured by the Expanded Disability Status Scale [EDSS]) and occurrence of relapses, 2 efficacy endpoints, respectively, in patients with remitting-relasping multiple sclerosis. Data for ALC, EDSS, and relapse rate were available from 1319 patients receiving placebo and/or cladribine tablets. Pharmacodynamic models were developed to characterize the time course of the endpoints. ALC-related measures were then evaluated as predictors of the efficacy endpoints...
May 10, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27771469/the-association-between-functional-hla-g-14bp-insertion-deletion-and-3142-c-g-polymorphisms-and-susceptibility-to-multiple-sclerosis
#2
Nadia Ben Fredj, Kaouthar Sakly, Daria Bortolotti, Mouna Aissi, Mahbouba Frih-Ayed, Antonella Rotola, Elisabetta Caselli, Franscesca Cura, Nabil Sakly, Mahjoub Aouni, Dario Di Luca, Roberta Rizzo
We aimed to investigate two main polymorphisms in the 3' untranslated region (3'UTR) of the HLA-G gene [14bp insertion/deletion (INS/DEL) and +3142 C>G] and to assess their impact on the soluble HLA-G (sHLA-G) production in patients with multiple sclerosis (MS). This study included 60 patients with relasping-remitting (RR) MS and 112 healthy donors (HD). Mutations were identified by PCR and PCR-RFLP, and serum sHLA-G quantification was performed by ELISA. For the 14bp INS/DEL polymorphism, variants frequencies were similar in patients and controls, whereas a significant increased frequency of the +3142 G allele was found in MS patients compared to HD (63...
December 2016: Immunology Letters
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