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Relasping remitting multiple sclerosis

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https://www.readbyqxmd.com/read/27771469/the-association-between-functional-hla-g-14bp-insertion-deletion-and-3142-c-g-polymorphisms-and-susceptibility-to-multiple-sclerosis
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Nadia Ben Fredj, Kaouthar Sakly, Daria Bortolotti, Mouna Aissi, Mahbouba Frih-Ayed, Antonella Rotola, Elisabetta Caselli, Franscesca Cura, Nabil Sakly, Mahjoub Aouni, Dario Di Luca, Roberta Rizzo
We aimed to investigate two main polymorphisms in the 3' untranslated region (3'UTR) of the HLA-G gene [14bp insertion/deletion (INS/DEL) and +3142 C>G] and to assess their impact on the soluble HLA-G (sHLA-G) production in patients with multiple sclerosis (MS). This study included 60 patients with relasping-remitting (RR) MS and 112 healthy donors (HD). Mutations were identified by PCR and PCR-RFLP, and serum sHLA-G quantification was performed by ELISA. For the 14bp INS/DEL polymorphism, variants frequencies were similar in patients and controls, whereas a significant increased frequency of the +3142 G allele was found in MS patients compared to HD (63...
October 19, 2016: Immunology Letters
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