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Genitourinary malignancies

Bimal Bhindi, R Houston Thompson, Christine M Lohse, Ross J Mason, Igor Frank, Brian A Costello, Aaron M Potretzke, Robert P Hartman, Theodora A Potretzke, Stephen A Boorjian, John C Cheville, Bradley C Leibovich
BACKGROUND: While the probability of malignant versus benign histology based on renal tumor size has been described, this alone does not sufficiently inform decision-making in the modern era since indolent malignant tumors can be managed with active surveillance. OBJECTIVE: To characterize the probability of aggressive versus indolent histology based on radiographic tumor size. DESIGN, SETTING, AND PARTICIPANTS: We evaluated patients who underwent radical or partial nephrectomy at Mayo Clinic for a pT1-2, pNx/0, M0 solid renal tumor between 1990 and 2010...
July 12, 2018: European Urology
D Barnes, R Rivera, S Gibson, C Craig, J Cragun, B Monk, D Chase
Background: Measuring QoL is essential to the field of gynecologic oncology but there seems to be limited standardized data regarding collecting QoL assessments throughout a patient's cancer treatment especially in non-clinical trial patients. The aim of this study is to explore patient characteristics that may be associated with poor quality of life (QoL) in women with gynecologic cancers at two University of Arizona Cancer Center (UACC) sites. Methods: A cross-sectional survey was conducted among English speaking women with gynecologic malignancies at the University of Arizona Cancer Centers in Phoenix and Tucson from April 2012 to July 2015...
2018: Gynecologic Oncology Research and Practice
Amandeep S Taggar, Kevin Martell, Siraj Husain, Michael Peacock, Michael Sia, Geoffrey Gotto
INTRODUCTION: Residency experiences and teaching in oncology among urology residents are variable across Canada. We sought to identify how radiation and medical oncology concepts, as they pertain to genitourinary malignancies, are taught to urology residents. METHODS: A total of 190 trainees enrolled in Canadian urology residency training programs were invited to participate in the study from January 2016 to June 2016. Participants completed an online questionnaire addressing the training they received...
May 28, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Benjamin M Dropkin, Giovanna A Giannico, Peter A Reisz, David F Penson, Ryan S Hsi
Background: Nephrogenic adenoma is a benign lesion found in the genitourinary tract, often at sites of prior inflammation, and is characterized by tubular, papillary, or tubulopapillary structures. It is thought to arise from distal migration and implantation of renal tubular cells into the renal pelvis, ureter, bladder, or urethra. These tumors often resemble malignant neoplasms. Morphologic variants include small tubules, signet ring-like pattern, papillary formations, flat pattern, and vessel-like structures...
2018: Journal of Endourology Case Reports
P M Cheon, R Rebello, A Naqvi, S Popovic, M Bonert, A Kapoor
Anastomosing hemangioma (ah) is a rare subtype of primary vascular tumour that can, clinically and radiologically, present similarly to malignant renal tumours such as renal cell carcinoma (rcc) and angiosarcoma. Rarely seen in the genitourinary system, the ah we report here occurred in a 40-year-old male patient diagnosed initially with rcc based on imaging and successfully treated by laparoscopic left radical nephrectomy, with adrenal sparing and perihilar lymph node dissection. The pathologic diagnosis of ah can be challenging on small biopsy specimens; we therefore opine that it is appropriate to excise these lesions to facilitate diagnosis and definitively exclude common renal cancers...
June 2018: Current Oncology
K Hosny, A Luk
Schistosoma haematobium is the species primarily responsible for the manifestation of schistosomiasis in the genitourinary tract. It is a parasitic disease caused by flukes (trematodes) of the genus Schistosoma, which can result in acute and chronic manifestation. We report a case of urinary schistosomiasis that initially presented as advanced bladder cancer with pulmonary metastasis on initial computed tomography scan. Further investigations revealed no cancer and pulmonary changes resolved with treatment...
July 2018: Annals of the Royal College of Surgeons of England
Kohei Ishioka, Fumikazu Koyama, Hiroyuki Kuge, Takashi Inoue, Shinsaku Obara, Takayuki Nakamoto, Yoshiyuki Sasaki, Yasuyuki Nakamura, Maiko Takeda, Chiho Ohbayashi, Masamitsu Kuwahara, Masayuki Sho
BACKGROUND: Anal gland carcinoma with perianal Paget's disease is rare, and anal gland carcinoma in situ is extremely rare. No cases of anal gland carcinoma in situ with pagetoid spread have been previously reported. CASE PRESENTATION: Physical examination in a 75-year-old woman revealed an erythematous, inflamed, perianal skin lesion. Neither colposcopy, cystoscopy, colonoscopy, computed tomography, nor magnetic resonance imaging showed evidence of malignant genitourinary or gastrointestinal lesions...
June 25, 2018: Surgical Case Reports
Katie S Murray, Massimiliano Spaliviero, Emily S Tonorezos, Mario E Lacouture, William D Tap, Kevin C Oeffinger, Hebert Alberto Vargas, James A Eastham
OBJECTIVES: To report a case of pelvic angiosarcoma in a 27-year-old man with Li-Fraumeni Syndrome (LFS) and evaluate the presentation and timeline of genitourinary (GU) tract involvement in LFS patients. METHODS: We retrospectively identified 39 LFS patients treated at our institution between 2000 and 2014; 7 (18%) had experienced a GU malignancy or an LFS-related malignancy involving the GU tract. Clinical characteristics, including dates of onset of first GU tract malignancies; pathologic findings; multimodal management; and familial history of LFS were reviewed...
June 20, 2018: Urology
Ashish P Wasnik, Ellen J Higgins, Giovanna A Fox, Elaine M Caoili, Matthew S Davenport
PURPOSE: To determine the yield of routine image-guided core biopsy of renal cell carcinoma (RCC) thermal ablation zones. METHODS: Institutional review board approval was obtained for this Health Insurance Portability and Accountability Act-compliant quality improvement effort. Routine core biopsy of RCC ablation zones was performed 2 months postablation from July 2003 to December 2014. Routine nicotinamide adenine dinucleotide staining was performed by specialized genitourinary pathologists to assess cell viability...
June 19, 2018: Academic Radiology
Zubair Khan, Nauman Siddiqui, Muhammad Wasif Saif
Mostly Streptococcus bovis ( S. bovis ) bacteremia and endocarditis (60%) has been found to be associated with underlying colorectal cancer (CRC). Enterococcus faecalis ( E. faecalis ) bacteremia and endocarditis has no identifiable source in most of the cases. E. faecalis is part of normal gut flora that can translocate through the intestine and cause the systemic infection. With any intestinal lesion or tumor, the barrier is breached and the gut flora like E. faecalis can translocate and cause infection. A 55-years-old male known to have non-ischemic cardiomyopathy with implantation of automated implantable cardioverter defibrillator (AICD) and atrial fibrillation presented with weight loss, fever and back pain...
June 2018: Gastroenterology Research
Trevor J Royce, Muhammad M Qureshi, Minh Tam Truong
BACKGROUND: The changing use of radiation as a first-line cancer therapy in the United States is poorly characterized. This study aims to report radiotherapy utilization and fractionation patterns during the first course of cancer treatment. METHODS: We extracted all solid tumor cases from 2004 to 2014 in the National Cancer Data Base, which captures only the first course of treatment. Patients were subcategorized by disease site: breast, central nervous system (CNS), gastrointestinal, genitourinary, gynecologic, head and neck (HN), musculoskeletal, skin, or thoracic...
June 11, 2018: Journal of the American College of Radiology: JACR
Kasondra Hartman, Jinghong Li, Tullika Garg
Primary malignancies of the female urethra are rare, accounting for less than 1% of genitourinary malignancies. Clear cell adenocarcinoma of the urethra (CCAU) occurs more infrequently, accounting for 0.003% of malignancies of the female urogenital tract. Definitive clinical diagnosis of CCAU is difficult and must be differentiated from tumors of the vagina. Currently, there is limited understanding of the causes of CCAU and there is no established standard of care for treatment. Immunohistochemistry and pathologic analysis can be used to identify the origin of the tumor...
July 2018: Urology Case Reports
Ali Aghdassi, Agnes Christoph, Frank Dombrowski, Paula Döring, Christoph Barth, Jan Christoph, Markus M Lerch, Peter Simon
BACKGROUND AND AIMS: Gastrointestinal stromal tumors (GISTs) are rare malignancies but the most common mesenchymal tumors of the digestive tract. Recent advances in diagnostic imaging and an increasing incidence will confront us more frequently with stromal tumors. This single center study aimed to characterize GIST patients in terms of tumor location, clinical presentation, metastasis formation, as well as associated secondary malignancies. METHODS: In a retrospective study, 104 patients with a histologically confirmed diagnosis of GIST, collected between 1993 and 2011, were characterized for several clinical features...
June 5, 2018: Digestive Diseases
Jessica M Ruck, Joseph K Canner, Thomas J Smith, Fabian M Johnston
BACKGROUND: Although mounting evidence supports the use of palliative care (PC) to improve care experiences and quality of life for oncology patients, the frequency of and factors associated with PC use during oncology-related hospitalizations remain unknown. MATERIALS AND METHODS: Using the National Inpatient Sample dataset, hospitalizations during 2012-2014 for a primary diagnosis of cancer with high risk of in-hospital mortality were identified. PC use was identified using the V66...
June 5, 2018: Journal of Palliative Medicine
Boglárka Pósfai, Levente Kuthi, Linda Varga, Ibolya Laczó, János Révész, Réka Kránicz, Anikó Maráz
BACKGROUND: Neuroendocrine neoplasms include a heterogeneous group of malignant tumors. Primary neuroendocrine tumors in the genitourinary tract are rare, comprising approximately 1-2% of genitourinary malignancies. MATERIALS AND METHODS: An extensive search was performed for publications between 2000 and 2018 regarding neuroendocrine tumors of the genitourinary tract. Epidemiological, clinical, histopathological, prognostic and therapeutic data were evaluated. RESULTS: Neuroendocrine tumors of the kidneys are exceedingly rare, mostly well-differentiated...
June 2018: Anticancer Research
Priyank Yadav, Varun Mittal, Pankaj Gaur, Devarshi Srivastava, Sanjoy Kumar Sureka, Anil Mandhani
OBJECTIVE: We present the outcomes of modification of cutaneous ureterostomy by extreme lateralization of the stoma and use of skin flap for formation of ureterostomy. MATERIAL AND METHODS: Between June 2012 and June 2016, 36 patients had modified cutaneous ureterostomy for ureteral obstruction due to pelvic malignancy or genitourinary tuberculosis. Transureteroureterostomy was made with cutaneous stoma at anterior axillary line between iliac crest and lower rib cage, instead of spinoumbilical line...
March 6, 2018: Turkish Journal of Urology
Kyle Scarberry, Lee Ponsky, Edward Cherullo, William Larchian, Donald Bodner, Matthew Cooney, Rodney Ellis, Gregory Maclennan, Ben Johnson, William Tabayoyong, Robert Abouassaly
INTRODUCTION: We sought to prospectively evaluate the effectiveness of the multidisciplinary tumour board (MTB) on altering treatment plans for genitourinary (GU) cancer patients. METHODS: All GU cancer patients seen at our tertiary care hospital are discussed at MTB. We prospectively collected data on adult patients discussed over a continuous, 20-month period. Physicians completed a survey prior to MTB to document their opinion on the likelihood of change in their patient's treatment plan...
May 14, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Yoshiyuki Nagumo, Aiko Maejima, Yuta Toyoshima, Motokiyo Komiyama, Kan Yonemori, Akihiko Yoshida, Hiroyuki Fujimoto
INTRODUCTION: Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor that involves various organs, but has a predilection for the urinary bladder in the genitourinary tract. Given that approximately half of all IMT cases have anaplastic lymphoma kinase (ALK) rearrangements, the ALK inhibitor crizotinib is suggested as a promising treatment for unresectable cases. No reports on neoadjuvant crizotinib therapy for locally advanced IMT of the bladder are available. PRESENTATION OF CASE: We report a case of a 17-year-old Japanese boy referred to our institution for painful urination and increased urinary frequency...
2018: International Journal of Surgery Case Reports
Juan Manuel Ochoa-López, Bernardo Gabilondo-Pliego, Sylvain Collura-Merlier, Jaime O Herrera-Cáceres, Mariano Sotomayor de Zavaleta, Francisco Tomás Rodríguez-Covarrubias, Guillermo Feria-Bernal, Fernando Gabilondo-Navarro, Ricardo Alonso Castillejos-Molina
PURPOSE: To provide data of the incidence and management of common urological malignancies in renal transplant recipients. MATERIALS AND METHODS: We conducted a retrospective analysis of a prospective database from August 1967 to August 2015. A descriptive analysis of the sample was performed. RESULTS: Among 1256 consecutive RTR a total of 88 patients developed malignancies (7%). There were 18 genitourinary tumors in the 16 patients (20.45% of all malignant neoplasms), incidence of 1...
April 30, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Kamonkiat Wirunsawanya, Dennis Thomas Bolger
We report a surprising pathological finding of miliary tuberculosis (TB) in a 49-year-old Chuukese, immunocompetent woman who was initially admitted to the hospital for a 1-month duration of chronic abdominal pain and intermittent fevers. Her clinical symptoms did not improve despite treatment with vancomycin and piperacillin-tazobactam. Based on the primary abdominal CT findings suggesting advanced ovarian cancer with omental metastatic disease, further workup with omental core biopsy was performed and demonstrated acute neutrophilic necrosis without malignant cells or granulomata...
May 12, 2018: BMJ Case Reports
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