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https://www.readbyqxmd.com/read/28635333/molecular-biomarkers-to-guide-precision-medicine-in-localized-prostate-cancer
#1
Minke Smits, Niven Mehra, Michiel Sedelaar, Winald Gerritsen, Jack A Schalken
Major advances through tumor profiling technologies, that include next-generation sequencing, epigenetic, proteomic and transcriptomic methods, have been made in primary prostate cancer, providing novel biomarkers that may guide precision medicine in the near future. Areas covered: The authors provided an overview of novel molecular biomarkers in tissue, blood and urine that may be used as clinical tools to assess prognosis, improve selection criteria for active surveillance programs, and detect disease relapse early in localized prostate cancer...
June 21, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28632505/obesity-and-prostate-cancer
#2
Marco Bandini, Giorgio Gandaglia, Alberto Briganti
PURPOSE OF REVIEW: To investigate the association between obesity and prostate cancer (PCa). RECENT FINDINGS: Obesity has been proposed to be involved in the pathogenesis of PCa through different biological mechanisms that include deregulation of the insulin axis, sex hormone secretion, adipokines signaling, and oxidative stress. Hypertrophic peritumoral adipocytes may also facilitate the local spread of PCa through the chemo-attraction of tumor cells. Clinical studies demonstrate that obesity might have clinical implications also in disease detection and management...
June 16, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28629785/-interest-using-3d-ultrasound-and-mri-fusion-biopsy-for-prostate-cancer-detection
#3
A Marien, A De Castro Abreu, I Gill, A Villers, O Ukimura
INTRODUCTION: The strategic therapy for prostate cancer depends on histo-pronostics data, which could be upgraded by obtaining targeted biopsies (TB) with MRI (magnetic resonance imagery) fusion 3D ultrasound. OBJECTIVES: To compare diagnostic yield of image fusion guided prostate biopsy using image fusion of multi-parametric MRI (mpMRI) with 3D-TRUS. MATERIALS AND METHODS: Between January 2010 and April 2013, 179 consecutive patients underwent outpatient TRUS biopsy using the real-time 3D TRUS tracking system (Urostation™)...
June 16, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28628758/intermediate-risk-prostate-cancer-and-active-surveillance-maximize-utilization-while-minimizing-failure
#4
EDITORIAL
Adam S Kibel
No abstract text is available yet for this article.
June 16, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28623636/eleven-year-management-of-prostate-cancer-patients-on-active-surveillance-what-have-we-learned
#5
Cristina Marenghi, Maria Francesca Alvisi, Federica Palorini, Barbara Avuzzi, Fabio Badenchini, Nice Bedini, Lara Bellardita, Davide Biasoni, Davide Bosetti, Alessandra Casale, Mario Catanzaro, Maurizio Colecchia, Letizia De Luca, Simona Donegani, Paola Dordoni, Rodolfo Lanocita, Massimo Maffezzini, Tiziana Magnani, Julia Menichetti, Antonella Messina, Sara Morlino, Biagio Paolini, Tiziana Rancati, Silvia Stagni, Antonio Tesone, Tullio Torelli, Edoardo Tulli Baldoin, Marta Vaiani, Sergio Villa, Silvia Villa, Nadia Zaffaroni, Nicola Nicolai, Roberto Salvioni, Riccardo Valdagni
PURPOSE: To evaluate the outcomes of active surveillance (AS) on patients with low-risk prostate cancer (PCa) and to identify predictors of disease reclassification. METHODS: In 2005, we defined an institutional AS protocol (Sorveglianza Attiva Istituto Nazionale Tumori [SAINT]), and we joined the Prostate Cancer Research International: Active Surveillance (PRIAS) study in 2007. Eligibility criteria included clinical stage ≤T2a, initial prostate-specific antigen (PSA) <10 ng/mL, and Gleason Pattern Score (GPS) ≤3 + 3 (both protocols); ≤25% positive cores with a maximum core length containing cancer ≤50% (SAINT); and ≤2 positive cores and PSA density <0...
June 14, 2017: Tumori
https://www.readbyqxmd.com/read/28623635/italian-cultural-adaptation-of-the-memorial-anxiety-for-prostate-cancer-scale-for-the-population-of-men-on-active-surveillance
#6
Maria F Alvisi, Claudia Repetto, Tiziana Rancati, Fabio Badenchini, Tiziana Magnani, Cristina Marenghi, Silvia Villa, Nicola Nicolai, Roberto Salvioni, Barbara Avuzzi, Riccardo Valdagni, Lara Bellardita
PURPOSE: The Memorial Anxiety Scale for Prostate Cancer (MAX-PC) is a self-report questionnaire that was developed in English to assess prostate cancer (PCa)-related anxiety. The aim of this study was to perform a cultural adaptation for the tool to be used in a population of Italian men on active surveillance (AS). METHODS: A total of 222 patients with localized PCa who were recruited for the Prostate Cancer Research International: Active Surveillance (PRIAS) protocol completed the MAX-PC...
June 14, 2017: Tumori
https://www.readbyqxmd.com/read/28621062/active-surveillance-in-prostate-cancer-new-efforts-new-voices-new-hope
#7
EDITORIAL
Spyridon P Basourakos, Karen Hoffman, Jeri Kim
No abstract text is available yet for this article.
July 2017: BJU International
https://www.readbyqxmd.com/read/28618431/tumour-heterogeneity-poses-a-significant-challenge-to-cancer-biomarker-research
#8
Karolina Cyll, Elin Ersvær, Ljiljana Vlatkovic, Manohar Pradhan, Wanja Kildal, Marte Avranden Kjær, Andreas Kleppe, Tarjei S Hveem, Birgitte Carlsen, Silje Gill, Sven Löffeler, Erik Skaaheim Haug, Håkon Wæhre, Prasanna Sooriakumaran, Håvard E Danielsen
BACKGROUND: The high degree of genomic diversity in cancer represents a challenge for identifying objective prognostic markers. We aimed to examine the extent of tumour heterogeneity and its effect on the evaluation of a selected prognostic marker using prostate cancer as a model. METHODS: We assessed Gleason Score (GS), DNA ploidy status and phosphatase and tensin homologue (PTEN) expression in radical prostatectomy specimens (RP) from 304 patients followed for a median of 10 years (interquartile range 6-12)...
June 15, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28614086/the-present-and-future-of-prostate-cancer-histopathology
#9
Jesse K McKenney
PURPOSE OF REVIEW: The present review describes recent changes in the histologic grading of prostatic adenocarcinoma and emerging data suggesting areas for further grade optimization. RECENT FINDINGS: The grading of prostatic adenocarcinoma has evolved over time, and optimization for active surveillance management has been one major driving force. Recent changes include adoption of the Grade Group system, which stratifies patients into one of five prognostic groups...
June 12, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28613997/psychological-distress-and-lifestyle-disruption-in-low-risk-prostate-cancer-patients-comparison-between-active-surveillance-and-radical-prostatectomy
#10
Andrew Glenday Matthew, Orit Raz, Kristen L Currie, Alyssa S Louis, Haiyan Jiang, Tal Davidson, Neil E Fleshner, Antonio Finelli, John Trachtenberg
OBJECTIVE: To quantify distress in men treated with radical prostatectomy (RP) or active surveillance (AS). METHODS: In a retrospective cross-sectional design, we assessed men via questionnaire and investigator-designed questions. RESULTS: RP patients worried more about cancer spread than AS patients. RP patients were influenced by friends for treatment decision, whereas AS patients were influenced by urologists. RP group report declines in intimacy and instrumental...
June 14, 2017: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/28612468/decision-making-processes-among-men-with-low-risk-prostate-cancer-a-survey-study
#11
Richard M Hoffman, Stephen K Van Den Eeden, Kimberly M Davis, Tania Lobo, George Luta, Jun Shan, David Aaronson, David F Penson, Amethyst D Leimpeter, Kathryn Taylor
OBJECTIVE: To characterize decision-making processes and outcomes among men expressing early treatment preferences for low-risk prostate cancer. METHODS: We conducted telephone surveys of men newly diagnosed with low-risk prostate cancer in 2012-14. We analyzed subject who had discussed prostate cancer treatment with a clinician and expressed a treatment preference. We asked about decision-making processes, including physician discussions, prostate-cancer knowledge, decision-making styles, treatment preference, and decisional conflict...
June 13, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28609648/when-no-treatment-is-the-best-treatment-active-surveillance-strategies-for-low-risk-prostate-cancers
#12
REVIEW
V Stavrinides, C C Parker, C M Moore
Although the incidence of prostate cancer is rising due to PSA screening and increased life expectancy, the metastatic potential of low-grade, organ-confined disease remains low. An increasing number of studies suggest that radical treatment in such cases confers little or no survival benefit at a significant cost to morbidity. Active surveillance is a promising management approach of such low-risk cancers: eligible patients are selected based on clinical and pathological findings at diagnosis and are regularly monitored with digital rectal examinations, PSA testing and biopsies...
May 23, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28609110/monitoring-tumor-volume-in-patients-with-prostate-cancer-undergoing-active-surveillance-is-mri-apparent-diffusion-coefficient-indicative-of-tumor-growth
#13
Veronica A Morgan, Christopher Parker, Alison MacDonald, Karen Thomas, Nandita M deSouza
OBJECTIVE: The purpose of this study was to measure longitudinal change in tumor volume of the dominant intraprostatic lesion and determine whether baseline apparent diffusion coefficient (ADC) and change in ADC are indicative of tumor growth in patients with prostate cancer undergoing active surveillance. SUBJECTS AND METHODS: The study group included 151 men (mean age, 68.1 ± 7.4 [SD] years; range, 50-83 years) undergoing active surveillance with 3D whole prostate, zonal, and tumor volumetric findings documented at endorectal MRI examinations performed at two time points (median interval, 1...
June 13, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28589550/characterization-of-a-low-risk-cohort-of-grade-group-2-prostate-cancer-patients-results-from-the-shared-equal-access-regional-cancer-hospital-database
#14
Kathleen F McGinley, Xizi Sun, Lauren E Howard, William J Aronson, Martha K Terris, Christopher J Kane, Christopher L Amling, Matthew R Cooperberg, Stephen J Freedland
OBJECTIVES: To examine if there is a subset of men with grade group 2 prostate cancer who could be potential candidates for active surveillance. METHODS: We used the Shared Equal Access Regional Cancer Hospital database to identify 776 men undergoing radical prostatectomy from 2006 to 2015 with >8 biopsy cores obtained and complete information. We compared men who fulfilled low-risk disease criteria (clinical stage T1c/T2a; grade group 1; prostate-specific antigen ≤10 ng/mL) with the exception of grade group 2 versus men who met all three low-risk criteria...
June 6, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28589399/prostate-biopsy-in-active-surveillance-protocols-immediate-re-biopsy-and-timing-of-subsequent-biopsies
#15
REVIEW
Jonathan H Wang, Tracy M Downs, E Jason Abel, Kyle A Richards, David F Jarrard
PURPOSE OF REVIEW: This manuscript reviews contemporary literature regarding prostate cancer active surveillance (AS) protocols as well as other tools that may guide the management of biopsy frequency and assess the possibility of progression in low-risk prostate cancer. RECENT FINDINGS: There is no consensus regarding the timing of surveillance biopsies; however, an immediate repeat biopsy within 12 months of diagnosis for patients considering AS confirms patients who have favorable risk disease yet also identifies patients who were undersampled initially...
July 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28589398/the-contemporary-role-of-multiparametric-magnetic-resonance-imaging-in-active-surveillance-for-prostate-cancer
#16
REVIEW
Ariel A Schulman, Christina Sze, Efrat Tsivian, Rajan T Gupta, Judd W Moul, Thomas J Polascik
PURPOSE OF REVIEW: Growing research supports the use of multiparametric magnetic resonance imaging (mpMRI) for the evaluation of localized prostate cancer (PCa). We highlight contemporary evidence supporting its use in active surveillance (AS). RECENT FINDINGS: The emerging approach to localized PCa favors risk-adapted screening, image-guided biopsies, and selective therapeutic interventions. mpMRI is increasingly critical to achieve each of these aims. Early evidence suggests a value of mpMRI before initial biopsy to guide fusion targeting and to rule out non-organ confined disease as well as in the initiation and serial monitoring of men on AS...
July 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28589395/testosterone-therapy-on-active-surveillance-and-following-definitive-treatment-for-prostate-cancer
#17
REVIEW
Vishnukamal Golla, Alan L Kaplan
PURPOSE OF REVIEW: Previously considered an absolute contraindication, the use of testosterone therapy in men with prostate cancer has undergone an important paradigm shift. Recent data has changed the way we approach the treatment of testosterone deficiency in men with prostate cancer. In the current review, we summarize and analyze the literature surrounding effects of testosterone therapy on patients being treated in an active surveillance protocol as well as following definitive treatment for prostate cancer...
July 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28581441/nk-cell-heparanase-controls-tumor-invasion-and-immune-surveillance
#18
Eva M Putz, Alyce J Mayfosh, Kevin Kos, Deborah S Barkauskas, Kyohei Nakamura, Liam Town, Katharine J Goodall, Dean Y Yee, Ivan Kh Poon, Nikola Baschuk, Fernando Souza-Fonseca-Guimaraes, Mark D Hulett, Mark J Smyth
NK cells are highly efficient at preventing cancer metastasis but are infrequently found in the core of primary tumors. Here, have we demonstrated that freshly isolated mouse and human NK cells express low levels of the endo-β-D-glucuronidase heparanase that increase upon NK cell activation. Heparanase deficiency did not affect development, differentiation, or tissue localization of NK cells under steady-state conditions. However, mice lacking heparanase specifically in NK cells (Hpsefl/fl NKp46-iCre mice) were highly tumor prone when challenged with the carcinogen methylcholanthrene (MCA)...
June 5, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28572868/prostate-cancer-patient-perspectives-on-the-use-of-information-in-treatment-decision-making-a-systematic-review-and-qualitative-meta-synthesis
#19
Sujane Kandasamy, Ahmad Firas Khalid, Umair Majid, Meredith Vanstone
BACKGROUND: Men with low- to intermediate-risk prostate cancer are typically asked to choose from a variety of treatment options, including active surveillance, radical prostatectomy, or brachytherapy. The Prolaris cell cycle progression test is intended to provide additional information on personal risk status to assist men with prostate cancer in their choice of treatment. To assist with assessing that new technology, this report synthesizes qualitative research on how men with prostate cancer use information to make decisions about treatment options...
2017: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/28572867/prolaris-cell-cycle-progression-test-for-localized-prostate-cancer-a-health-technology-assessment
#20
(no author information available yet)
BACKGROUND: Prostate cancer is very common and many localized tumours are non-aggressive. Determining which cancers are aggressive is important for choosing the most appropriate treatment (e.g., surgery, radiation, active surveillance). Current clinical risk stratification is reliable in forecasting the prognosis of groups of men with similar clinical and pathologic characteristics, but there is residual uncertainty at the individual level. The Prolaris cell cycle progression (CCP) test, a genomic test that estimates how fast tumour cells are proliferating, could potentially be used to improve the accuracy of individual risk assessment...
2017: Ontario Health Technology Assessment Series
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