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Active surveillance prostate

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https://www.readbyqxmd.com/read/27900214/are-magnetic-resonance-imaging-undetectable-prostate-tumours-clinically-significant-results-of-histopathological-analyses
#1
Kristian D Stensland, Karl Coutinho, Adele R Hobbs, Lindsay Haines, Shemille A Collingwood, Young Suk Kwon, Simon J Hall, Maria Katsigeorgis, Seyed Behzad Jazayeri, David B Samadi
OBJECTIVE: To investigate whether tumours at threshold values for detection on magnetic resonance imaging (MRI) represent clinically significant tumours or not, and therefore the utility of MRI in active surveillance (AS) protocols. PATIENTS AND METHODS: A retrospective analysis of a single institution database was performed after Institutional Review Board approval. Between 2010 and 2013, 1633 patients underwent robot-assisted laparoscopic prostatectomy (RALP) at a single institution by a single surgeon...
December 2016: Arab Journal of Urology
https://www.readbyqxmd.com/read/27898099/clinical-and-molecular-rationale-to-retain-the-cancer-descriptor-for-gleason-score-6-disease
#2
REVIEW
Chad A Reichard, Eric A Klein
Treatment choices for men with indolent prostate cancer include active surveillance or definitive local therapy. Overtreatment of these patients is an important current problem. Treatment decisions are often made jointly by the clinician and the patient, partly based on the tumour's Gleason score. To reduce the burden of overtreatment, the clinical significance of Gleason score 3 + 3 = 6 prostate cancer has been questioned and some have advocated that Gleason pattern 3 should be stripped of its cancer status...
November 29, 2016: Nature Reviews. Urology
https://www.readbyqxmd.com/read/27889277/evaluating-the-four-kallikrein-panel-of-the-4kscore-for-prediction-of-high-grade-prostate-cancer-in-men-in-the-canary-prostate-active-surveillance-study
#3
Daniel W Lin, Lisa F Newcomb, Marshall D Brown, Daniel D Sjoberg, Yan Dong, James D Brooks, Peter R Carroll, Matthew Cooperberg, Atreya Dash, William J Ellis, Michael Fabrizio, Martin E Gleave, Todd M Morgan, Peter S Nelson, Ian M Thompson, Andrew A Wagner, Yingye Zheng
BACKGROUND: Diagnosis of Gleason 6 prostate cancer can leave uncertainty about the presence of undetected aggressive disease. OBJECTIVE: To evaluate the utility of a four kallikrein (4K) panel in predicting the presence of high-grade cancer in men on active surveillance. DESIGN, SETTING, AND PARTICIPANTS: Plasma collected before the first and subsequent surveillance biopsies was assessed for 718 men prospectively enrolled in the multi-institutional Canary PASS trial...
November 23, 2016: European Urology
https://www.readbyqxmd.com/read/27879271/vitamin-d3-prevents-calcium-induced-progression-of-early-stage-prostate-tumors-by-counteracting-trpc6-and-calcium-sensing-receptor-upregulation
#4
Sophie Bernichtein, Natascha Pigat, Nicolas Barry Delongchamps, Florence Boutillon, Virginie Verkarre, Philippe Camparo, Edouard Reyes-Gomez, Arnaud Méjean, Stephane Marie Oudard, Eve M Lepicard, Melanie Viltard, Jean-Claude Souberbielle, Gerard Friedlander, Thierry Capiod, Vincent Goffin
Active surveillance has emerged as an alternative to immediate treatment for men with low-risk prostate cancer. Accordingly, identification of environmental factors that faciliate progression to more aggressive stages is critical for disease prevention. Although calcium-enriched diets have been speculated to increase prostate cancer risk, their impact on early-stage tumors remains unexplored. In this study, we addressed this issue with a large interventional animal study. Mouse models of fully penetrant and slowly-evolving prostate tumorigenesis showed that a high calcium diet dramatically accelerated the progression of prostate intraepithelial neoplasia, by promoting cell proliferation, micro-invasion, tissue inflammation and expression of acknowledged prostate cancer markers...
November 22, 2016: Cancer Research
https://www.readbyqxmd.com/read/27864108/biopsy-perineural-invasion-in-prostate-cancer-patients-who-are-candidates-for-active-surveillance-by-strict-and-expanded-criteria
#5
Robert M Turner, Todd S Yecies, Jonathan G Yabes, Benjamin T Ristau, Elen Woldemichael, Benjamin J Davies, Bruce L Jacobs, Joel B Nelson
OBJECTIVE: To evaluate the association of biopsy perineural invasion (PNI) with adverse pathological findings on radical prostatectomy in patients who would have been candidates for active surveillance (AS). METHODS: Using a prospectively populated database of 3084 men who underwent open radical prostatectomy, candidates for AS by strict (Johns Hopkins) and expanded (University of Toronto) criteria were identified. The presence of adverse pathologic features at radical prostatectomy was compared between those men with and without biopsy PNI...
November 15, 2016: Urology
https://www.readbyqxmd.com/read/27862832/risk-stratification-a-tool-to-predict-the-course-of-active-surveillance-for-localized-prostate-cancer
#6
Jan Herden, Axel Heidenreich, Lothar Weissbach
OBJECTIVE: To investigate a cohort of patients under active surveillance (AS) for localized prostate cancer (PCa) concerning possible differences in discontinuation rates, subsequent therapies, reasons for intervention, and pathologic findings after deferred surgery depending on stratification in very low-, low-, and intermediate/high-risk PCa. PATIENTS AND METHODS: HAROW is a non-interventional, observational, outcomes research study on the management of localized PCa in the community setting...
November 10, 2016: BJU International
https://www.readbyqxmd.com/read/27862602/active-surveillance-for-favourable-risk-prostate-cancer-is-there-a-greater-psychological-impact-than-previously-thought-a-systematic-mixed-studies-literature-review
#7
REVIEW
Eimear Ruane-McAteer, Sam Porter, Joe M O'Sullivan, Olinda Santin, Gillian Prue
OBJECTIVE: Active Surveillance (AS) allows men with favourable-risk prostate cancer (PCa) to avoid or postpone active treatment and hence spares potential adverse side effects for a significant proportion of these patients. Active surveillance may create an additional emotional burden for these patients. The aim of the review was to determine the psychological impact of AS to inform future study in this area and to provide recommendations for clinical practice. METHODS: Studies were identified through database searching from inception to September 2015...
November 15, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27858090/dramatic-increase-in-the-utilization-of-multiparametric-magnetic-resonance-imaging-for-detection-and-management-of-prostate-cancer
#8
Daniel T Oberlin, David D Casalino, Frank H Miller, Joshua J Meeks
PURPOSE: Multiparametric MRI (mpMRI) of the prostate is an evolving technology that provides functional information of the prostate that helps distinguish benign from malignant lesions. We hypothesized that mpMRI is rapidly adopted in the US to fill the unmet need for a non-invasive, accurate screening tool. The aim of this study is to assess the increasing utilization of mpMRI for the diagnosis and management of prostate cancer. METHODS: We conducted a retrospective review of an institutional clinical data repository of four million patients...
November 17, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27856226/indications-utilization-and-complications-following-prostate-biopsy-a-new-york-state-analysis
#9
Joshua A Halpern, Art Sedrakyan, Brian Dinerman, Wei-Chun Hsu, Jialin Mao, Jim C Hu
PURPOSE: Uptake of active surveillance and changes in prostate cancer care may affect utilization of and complications following prostate needle biopsy (PNBx). We characterized recent trends and risk factors for PNBx complications using a statewide, all-payer cohort. MATERIALS AND METHODS: We utilized the New York Statewide Planning and Research Cooperation System (SPARCS) to identify PNBx performed between 2011 and 2014 via transrectal (N=9472) and transperineal (N=421) approach...
November 14, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27846936/-ccafu-french-national-guidelines-2016-2018-on-prostate-cancer
#10
F Rozet, C Hennequin, J-B Beauval, P Beuzeboc, L Cormier, G Fromont, P Mongiat-Artus, A Ouzzane, G Ploussard, D Azria, I Brenot-Rossi, G Cancel-Tassin, O Cussenot, T Lebret, X Rebillard, M Soulié, R Renard-Penna, A Méjean
OBJECTIVES: The purpose of the guidelines national committee CCAFU was to propose updated french guidelines for localized and metastatic prostate cancer (PCa). METHODS: A Medline search was achieved between 2013 and 2016, as regards diagnosis, options of treatment and follow-up of PCa, to evaluate different references with levels of evidence. RESULTS: Epidemiology, classification, staging systems, diagnostic evaluation are reported. Disease management options are detailed...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27845218/determination-of-the-role-of-negative-magnetic-resonance-imaging-of-the-prostate-in-clinical-practice-is-biopsy-is-still-necessary
#11
Robert S Wang, Eric H Kim, Joel M Vetter, Kathryn J Fowler, Anup S Shetty, Aaron J Mintz, Niraj G Badhiwala, Robert L Grubb, Gerald L Andriole
OBJECTIVES: To assess the negative predictive value (NPV) of multi-parametric MRI (mpMRI) for detection of prostate cancer (PCa) in routine clinical practice, and to identify characteristics of patients for whom mpMRI fails to detect high-grade (Gleason ≥7) disease. METHODS: We reviewed our prospectively maintained database of consecutive men who received prostate mpMRI at our institution, interpreted by a clinical practice of academic radiologists. Between January 2012 and December 2015, 84 men without any MR suspicious regions (MSRs) according to prior institutional classification, or with PI-RADS 1-2 lesions according to the PI-RADS system, underwent standard template transrectal ultrasound-guided (TRUS) prostate biopsy...
November 11, 2016: Urology
https://www.readbyqxmd.com/read/27845129/re-variation-in-testosterone-levels-and-health-related-quality-of-life-in-men-diagnosed-with-prostate-cancer-on-active-surveillance
#12
Allen D Seftel
No abstract text is available yet for this article.
December 2016: Journal of Urology
https://www.readbyqxmd.com/read/27843346/the-danish-prostate-cancer-database
#13
REVIEW
Mary Nguyen-Nielsen, Søren Høyer, Søren Friis, Steinbjørn Hansen, Klaus Brasso, Erik Breth Jakobsen, Mette Moe, Heidi Larsson, Mette Søgaard, Anne Nakano, Michael Borre
AIM OF DATABASE: The Danish Prostate Cancer Database (DAPROCAdata) is a nationwide clinical cancer database that has prospectively collected data on patients with incident prostate cancer in Denmark since February 2010. The overall aim of the DAPROCAdata is to improve the quality of prostate cancer care in Denmark by systematically collecting key clinical variables for the purposes of health care monitoring, quality improvement, and research. STUDY POPULATION: All Danish patients with histologically verified prostate cancer are included in the DAPROCAdata...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27833462/health-economic-impact-and-prospective-clinical-utility-of-oncotype-dx%C3%A2-genomic-prostate-score
#14
David Albala, Michael J Kemeter, Phillip G Febbo, Ruixiao Lu, Vincy John, Dylan Stoy, Bela Denes, Marybeth McCall, Alan W Shindel, Frank Dubeck
Prostate cancer (CaP) will be diagnosed in approximately 181,000 American men in 2016. Despite the high number of deaths from CaP in the United States, the disease has a protracted natural history and many men diagnosed with CaP will not die of the disease regardless of treatment. Unfortunately, identification of men with truly indolent/ nonaggressive CaP is challenging; limitations of conventional diagnostic modalities diminish the ability of physicians to accurately stage every case of CaP based on biopsy results alone...
2016: Reviews in Urology
https://www.readbyqxmd.com/read/27827421/intraprostatic-locations-of-tumor-foci-of-higher-grade-missed-by-diagnostic-prostate-biopsy-among-potential-candidates-for-active-surveillance
#15
Kwangmo Kim, Jung Keun Lee, Gheeyoung Choe, Sung Kyu Hong
To establish optimal biopsy scheme for selection of candidates for active surveillance (AS) among prostate cancer (PCa) patients, information on topographical distribution of tumor foci of higher grade missed by contemporary biopsy amongst potential candidates of AS would certainly be useful. Thus we analyzed topographic distribution of tumor foci by examining prostatectomy specimens in 444 patients who underwent radical prostatectomy for low risk PCa. Anterior and posterior prostate areas were demarcated by a horizontal line drawn at midpoint of prostatic urethra...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27822603/-treatment-costs-of-localized-prostate-cancer-in-germany-economic-results-from-the-harow-observational-study
#16
T Reinhold, C Dornquast, C Börgermann, L Weißbach
BACKGROUND: Prostate cancer (PCa) is the most common cancer in men. For medical treatment of PCa, a number of therapies are available. The economic consequences associated with these individual treatment options in routine care in Germany are unclear so far. METHODS: The present analysis was based on the Germany-wide HAROW observational study, which was conducted from 2008-2013. During this study, all participating physicians and involved patients reported and documented individual health care resource consumption...
November 7, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27816300/racial-variation-in-patient-reported-outcomes-following-treatment-for-localized-prostate-cancer-results-from-the-ceasar-study
#17
Mark D Tyson, JoAnn Alvarez, Tatsuki Koyama, Karen E Hoffman, Matthew J Resnick, Xiao-Cheng Wu, Matthew R Cooperberg, Michael Goodman, Sheldon Greenfield, Ann S Hamilton, Mia Hashibe, Lisa E Paddock, Antoinette Stroup, Vivien W Chen, David F Penson, Daniel A Barocas
BACKGROUND: Relatively little is known about the relationship between race/ethnicity and patient-reported outcomes after contemporary treatments for localized prostate cancer. OBJECTIVE: To test the hypothesis that treatment-related changes in urinary, bowel, sexual, and hormonal function vary by race/ethnicity. DESIGN, SETTING, AND PARTICIPANTS: The Comparative Effectiveness Analysis of Surgery and Radiation (CEASAR) study is a prospective, population-based, observational study that enrolled 3708 men diagnosed with localized prostate cancer in 2011-2012...
November 2, 2016: European Urology
https://www.readbyqxmd.com/read/27816297/quantifying-the-transition-from-active-surveillance-to-watchful-waiting-among-men-with-very-low-risk-prostate-cancer
#18
Mieke Van Hemelrijck, Hans Garmo, Lars Lindhagen, Ola Bratt, Pär Stattin, Jan Adolfsson
BACKGROUND: Active surveillance (AS) is commonly used for men with low-risk prostate cancer (PCa). When life expectancy becomes too short for curative treatment to be beneficial, a change from AS to watchful waiting (WW) follows. Little is known about this change since it is rarely documented in medical records. OBJECTIVE: To model transition from AS to WW and how this is affected by age and comorbidity among men with very low-risk PCa. DESIGN, SETTING, AND PARTICIPANTS: National population-based healthcare registers were used for analysis...
November 2, 2016: European Urology
https://www.readbyqxmd.com/read/27810448/timing-of-adverse-prostate-cancer-reclassification-on-first-surveillance-biopsy-results-from-the-canary-prostate-cancer-active-surveillance-study
#19
Liam C Macleod, William J Ellis, Lisa F Newcomb, Yingye Zheng, James D Brooks, Peter R Carroll, Martin E Gleave, Raymond S Lance, Peter S Nelson, Ian M Thompson, Andrew A Wagner, John T Wei, Daniel W Lin
PURPOSE: During active surveillance (AS) for localized prostate cancer (PCa), first surveillance biopsy timing varies. We analyzed the Canary Prostate Cancer Active Surveillance Study (PASS), to determine biopsy timing influence on rates of PCa adverse reclassification at first AS biopsy. MATERIALS/METHODS: Of 1,085 participants in PASS, 421 had <34% cores involved with cancer, Gleason sum ≤6, and thereafter underwent on-study AS biopsy. Reclassification was defined as increase in Gleason sum and/or ≥34% of cores with PCa...
October 31, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27810256/the-effect-of-an-online-support-group-on-patients-treatment-decisions-for-localized-prostate-cancer-an-online-survey
#20
Johannes Huber, Philipp Maatz, Tanja Muck, Bastian Keck, Hans-Christoph Friederich, Wolfgang Herzog, Andreas Ihrig
OBJECTIVE: To analyze the effect of an online support group (OSG) on the final treatment decision for localized prostate cancer. METHODS: We performed a cross-sectional descriptive study of the largest German prostate cancer OSG between July and October 2013. The online survey comprised 127 questions covering sociodemographic and disease-related information, decision-making habits, health-related quality of life, distress, depression, and anxiety. The primary outcome was to measure the effect of an OSG on the final treatment decision...
October 31, 2016: Urologic Oncology
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