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Active surveillance prostate

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https://www.readbyqxmd.com/read/29242596/total-energy-expenditure-and-vigorous-intensity-physical-activity-are-associated-with-reduced-odds-of-reclassification-among-men-on-active-surveillance
#1
David E Guy, Avi Vandersluis, Laurence H Klotz, Neil Fleshner, Alexander Kiss, Chris Parker, Vasundara Venkateswaran
BACKGROUND: Research examining the association between physical activity (PA) and prostate cancer (PCa) has accumulated; however, few studies have examined this association in the context of active surveillance. The current study examines this among men initially diagnosed with favorable-risk PCa and managed by active surveillance at Sunnybrook Health Sciences Centre in Canada and the Royal Marsden Hospital in the United Kingdom. METHODS: Participants completed a questionnaire on daily participation in non-leisure, transport, and recreational PA...
December 14, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29240360/decision-making-in-prostate-cancer-%C3%A2-choosing-active-surveillance-over-other-treatment-options-a-literature-review
#2
David R Bayliss, Jed Duff, Philip Stricker, Kim Walker
A literature review was done using the Cognitive-Social Health Information Processing (C-SHIP) framework to identify how and why men diagnosed with prostate cancer choose active surveillance over other treatment options. Findings indicated men who choose active surveillance have a stronger preference for active or collaborative decision-making than those who choose other treatments. Men primarily choose active surveillance to avoid the side effects of incontinence and erectile dysfunction. This literature review informed the study by Bayliss, Duff, Strieker, and Walker (2016) and found physician recommendation to be the most influential factor when patients make a treatment decision...
January 2017: Urologic Nursing
https://www.readbyqxmd.com/read/29239082/utility-of-early-transperineal-template-guided-prostate-biopsy-for-risk-stratification-in-men-undergoing-active-surveillance-for-prostate-cancer
#3
James Voss, Raj Pal, Shaista Ahmed, Magnus Hannah, Adil Jaulim, Thomas Walton
OBJECTIVE: To assess the accuracy and utility of routine multiparametric MRI (mp-MRI) and transperineal template-guided prostate biopsy (TPB) following enrolment on to active surveillance. PATIENTS AND METHODS: From April 2012 to December 2016 consecutive men from our single institution diagnosed with low or intermediate risk prostate cancer on TRUS biopsy were offered further staging with early mp-MRI and TPB within 12 months of diagnosis. Data was collected prospectively...
December 14, 2017: BJU International
https://www.readbyqxmd.com/read/29237932/current-progress-and-controversies-in-prostate-cancer-management
#4
REVIEW
De-Xin Dong, Zhi-Gang Ji
OBJECTIVE: The optimal management strategy for prostate cancer (PCa) remains controversial. We performed a systemic review of current progress and controversies regarding the diagnosis and treatment of PCa. DATA SOURCES: We searched PubMed for recently published articles up to July 2017 using the following key words: "prostate cancer," "progress," "controversy," "immunotherapy," and "prevention." STUDY SELECTION: Articles were obtained and reviewed to provide a systematic review of the current progress and controversies regarding PCa management...
December 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29231973/comparative-effectiveness-of-prostate-cancer-screening-between-the-ages-of-55-and-69-years-followed-by-active-surveillance
#5
Tiago M de Carvalho, Eveline A M Heijnsdijk, Harry J de Koning
BACKGROUND: Because of the recent grade C draft recommendation by the US Preventive Services Task Force (USPSTF) for prostate cancer screening between the ages of 55 and 69 years, there is a need to determine whether this could be cost-effective in a US population setting. METHODS: This study used a microsimulation model of screening and active surveillance (AS), based on data from the European Randomized Study of Screening for Prostate Cancer and the Surveillance, Epidemiology, and End Results Program, for the natural history of prostate cancer and Johns Hopkins AS cohort data to inform the probabilities of referral to treatment during AS...
December 12, 2017: Cancer
https://www.readbyqxmd.com/read/29230413/establishment-and-application-of-prostate-cancer-circulating-tumor-cells-in-the-era-of-precision-medicine
#6
REVIEW
Yoon Seok Suh, Jae Young Joung, Sung Han Kim, Ho Kyung Seo, Jinsoo Chung, Kang Hyun Lee
Prostate cancer (PC) is the second most common cancer in men and is the fifth leading cause of cancer-related deaths worldwide. Additionally, there is concern for overdiagnosis and overtreatment of PC. Thus, selection of an appropriate candidate for active surveillance as well as more accurate and less invasive tools for monitoring advanced PC is required. Circulating tumor cells (CTCs) have emerged as a liquid biopsy tool; there have been several reports on its role, technologies, and applications to various cancers, including PC...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29230007/elevated-preoperative-neutrophil-lymphocyte-ratio-predicts-upgrading-at-radical-prostatectomy
#7
Mehmet Özsoy, Marco Moschini, Harun Fajkovic, Francesco Soria, Christian Seitz, Tobias Klatte, Kilian Gust, Alberto Briganti, Pierre I Karakiewicz, Morgan Roupret, Gero Kramer, Shahrokh F Shariat
BACKGROUND: Neutrophil-lymphocyte ratio (NLR) is a widely used, representative marker of systemic inflammatory response within the body. NLR can be calculated from simple, inexpensive peripheral blood samples. High NLR is a negative prognostic factor in a variety of malignancies including urological tumors. In this study, we aim to assess the prognostic value of preoperative neutrophil- lymphocyte ratio (NLR) in patients treated with radical prostatectomy (RP) for localized prostate cancer (PCa)...
December 11, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29226251/tissue-based-biomarkers-in-prostate-cancer
#8
Timothy N Clinton, Aditya Bagrodia, Yair Lotan, Vitaly Margulis, Ganesh V Raj, Solomon L Woldu
Introduction: Prostate cancer is a heterogeneous disease. Existing risk stratification tools based on standard clinlicopathologic variables (prostate specific antigen [PSA], Gleason score, and tumor stage) provide a modest degree of predictive ability. Advances in high-throughput sequencing has led to the development of several novel tissue-based biomarkers that can improve prognostication in prostate cancer management. Areas Covered: The authors review commercially-available, tissue-based biomarker assays that improve upon existing risk-stratification tools in several areas of prostate cancer management, including the appropriateness of active surveillance and aiding in decision making regarding the use of adjuvant therapy...
2017: Expert Review of Precision Medicine and Drug Development
https://www.readbyqxmd.com/read/29225057/comparison-of-pathological-and-oncologic-outcomes-in-favorable-risk-gs-3-4-and-low-risk-gs6-prostate-cancer-considerations-for-active-surveillance
#9
Derek J Gearman, Alessandro Morlacco, John C Cheville, Laureano J Rangel, R Jeffrey Karnes
PURPOSE: Recent NCCN guidelines report that patients with biopsy GS 3+4/GG2 but otherwise favorable features as active surveillance (AS) candidates. However, little is known about their long-term outcomes compared to low-risk GS6/GG1 group. This study aims to clarify the risk of adverse features and oncologic outcomes for surgically-treated favorable GG2 vs GG1 patients. MATERIAL AND METHODS: Our prospectively maintained RP database was queried for all patients with biopsy GG1 or GG2 PCa who otherwise fulfilled the NCCN "low risk" definition (PSA < 10 ng/ml, cT≤2a) and underwent radical prostatectomy (RP) from 1987 to 2014 (n = 8095)...
December 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29217830/patient-reported-quality-of-life-progression-in-men-with-prostate-cancer-following-primary-cryotherapy-cyberknife-or-active-holistic-surveillance
#10
Glenn T Werneburg, Michael Kongnyuy, Daniel M Halpern, Jose M Salcedo, Kaitlin E Kosinski, Jonathan A Haas, Jeffrey T Schiff, Anthony T Corcoran, Aaron E Katz
BACKGROUND: Technological advancements have led to the success of minimally invasive treatment modalities for prostate cancer such as CyberKnife and Cryotherapy. Here, we investigate patient-reported urinary function, bowel habits, and sexual function in patients following CyberKnife (CK) or Cryotherapy treatment, and compare them with active holistic surveillance (AHS) patients. METHODS: An IRB-approved institutional database was retrospectively reviewed for patients who underwent CK, Cryotherapy, or AHS...
December 7, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29213105/preoperative-prostate-health-index-predicts-poor-pathologic-outcomes-of-radical-prostatectomy-in-patients-with-biopsy-detected-low-risk-patients-prostate-cancer-results-from-a-chinese-prospective-cohort
#11
Bo Tang, Cheng-Tao Han, Xiao-Lin Lu, Fang-Ning Wan, Cui-Zhu Zhang, Yao Zhu, Ding-Wei Ye
OBJECTIVE: To determine the performance of the prostate health index (PHI) in predicting pathologic outcomes of radical prostatectomy (RP) in Chinese patients with low-risk prostate cancer (PCa). METHODS: Of all consecutive patients who underwent RP in one tertiary center from September 2013 to January 2017, we prospectively examined the data of 140 patients with low-risk PCa based on the Prostate Cancer Research International: Active Surveillance (PRIAS) criteria...
December 6, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29212392/multi-parametric-magnetic-resonance-imaging-monitoring-patients-in-active-surveillance-for-prostate-cancer-a-prospective-cohort-study
#12
Maria Carlsen Elkjær, Morten Heebøll Andersen, Søren Høyer, Bodil Ginnerup Pedersen, Michael Borre
OBJECTIVES: To evaluate the use of multi-parametric magnetic resonance imaging (mpMRI) and mpMRI guided biopsies (MRGB) for monitoring an active surveillance (AS) prostate cancer cohort. MATERIALS AND METHODS: One year after initial diagnostic TRUS guided biopsy (TRUS-bx), baseline mpMRI, and enrolment in an AS program patients underwent a one year follow-up comprising the usual TRUS-bx and an mpMRI. Prostate MRI lesions were scored on the five-point PIRADS scale version 2...
December 7, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/29209723/active-surveillance-for-prostate-cancer
#13
Richard S Matulewicz, Adam B Weiner, Edward M Schaeffer
No abstract text is available yet for this article.
December 5, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29199015/contemporary-prognostic-indicators-for-prostate-cancer-incorporating-international-society-of-urological-pathology-recommendations
#14
REVIEW
Lars Egevad, Brett Delahunt, Glen Kristiansen, Hemamali Samaratunga, Murali Varma
Prognostic assessment is a key element in the management of patients with prostate cancer as it informs both treatment, follow-up and outcome prediction. Tumour grade should be based upon the novel and evidence-based recommendations of the International Society of Urological Pathology (ISUP) Consensus Conference of 2014, with ISUP grades 1-5 being derived from 2005 ISUP modified Gleason grading, i.e., ISUP grade 1 (3 + 3 = 6), grade 2 (3 + 4 = 7), grade 3 (4 + 3 = 7), grade 4 (3 + 5 = 8, 5 + 3 = 8, 4 + 4 = 8), and grade 5 (4 + 5 = 9 5 + 4 = 9, 5 + 5 = 10)...
November 30, 2017: Pathology
https://www.readbyqxmd.com/read/29198639/baseline-multiparametric-mri-for-selection-of-prostate-cancer-patients-suitable-for-active-surveillance-which-features-matter
#15
Francesco Sanguedolce, Giuseppe Petralia, Heminder Sokhi, Elena Tagliabue, Nicola Anyamene, Giles Hellawell, Anwar R Padhani
INTRODUCTION: Increasing evidence has supported the use of multiparametric magnetic resonance imaging (mpMRI) for the detection of prostate cancer. However, its role in selecting patients clinically suitable for active surveillance (AS) is still in development. We aimed to find relevant mpMRI features that might be helpful for refinement of the selection of low-risk prostate cancer patients for AS. We also evaluated the interobserver variability in reporting prostate mpMRI features. PATIENTS AND METHODS: From 2008 to 2012, 135 patients were selected for AS using Epstein criteria...
November 21, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29196209/pathologic-outcomes-of-gleason-6-favorable-intermediate-risk-prostate-cancer-treated-with-radical-prostatectomy-implications-for-active-surveillance
#16
David D Yang, Brandon A Mahal, Vinayak Muralidhar, Marie E Vastola, Ninjin Boldbaatar, Shelby A Labe, Michelle D Nezolosky, Peter F Orio, Martin T King, Neil E Martin, Kent W Mouw, Quoc-Dien Trinh, Paul L Nguyen
BACKGROUND: The safety of active surveillance (AS) for Gleason 6 favorable intermediate-risk (FIR) prostate cancer is unknown. To provide guidance, we examined the incidence and predictors of upgrading or upstaging for Gleason 6 FIR patients treated with radical prostatectomy. PATIENTS AND METHODS: We identified 2807 men in the National Cancer Database diagnosed from 2010 to 2012 with Gleason 6 FIR disease (<50% positive biopsy cores [PBC] with either prostate-specific antigen [PSA] of 10-20 ng/mL or cT2b-T2c disease) treated with radical prostatectomy...
November 9, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29188202/seminal-plasma-enables-selection-and-monitoring-of-active-surveillance-candidates-using-nuclear-magnetic-resonance-based-metabolomics-a-preliminary-investigation
#17
Matthew J Roberts, Renee S Richards, Clement W K Chow, Marion Buck, John Yaxley, Martin F Lavin, Horst Joachim Schirra, Robert A Gardiner
Background: Diagnosis and monitoring of localized prostate cancer requires discovery and validation of noninvasive biomarkers. Nuclear magnetic resonance (NMR)-based metabolomics of seminal plasma reportedly improves diagnostic accuracy, but requires validation in a high-risk clinical cohort. Materials and methods: Seminal plasma samples of 151 men being investigated for prostate cancer were analyzed with 1H-NMR spectroscopy. After adjustment for buffer (add-to-subtract) and endogenous enzyme influence on metabolites, metabolite profiling was performed with multivariate statistical analysis (principal components analysis, partial least squares) and targeted quantitation...
December 2017: Prostate International
https://www.readbyqxmd.com/read/29188200/management-and-outcomes-of-gleason-six-prostate-cancer-detected-on-needle-biopsy-a-single-surgeon-experience-over-6%C3%A2-years
#18
Brayden March, George Koufogiannis, Mark Louie-Johnsun
Objective: To assess the management and oncological outcomes in men diagnosed with Gleason score (GS) 6 prostate cancer on needle biopsy in a regional centre, as compared with published international data. Materials and methods: A retrospective analysis was conducted of patients who were diagnosed with GS 6 prostate cancer via transrectal ultrasound-guided or transperineal biopsy between June 2009 and September 2015 under the care of a single surgeon. Data were obtained from a prospectively collected database...
December 2017: Prostate International
https://www.readbyqxmd.com/read/29186937/how-to-use-pet-ct-in-the-evaluation-of-response-to-radiotherapy
#19
Pierre Decazes, Sébastien Thureau, Bernard Dubray, Pierre Vera
INTRODUCTION: Radiotherapy is a major treatment modality for many cancers. Tumor response after radiotherapy determines the subsequent steps of the patient's management (surveillance, adjuvant or salvage treatment and palliative care). Tumor response assessed during radiotherapy offers a promising opportunity to adapt the treatment plan to reduced / increased target volume, to specifically target sub-volumes with relevant biological characteristics (metabolism, hypoxia, proliferation ...
November 28, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29181514/comparative-analysis-of-biopsy-upgrading-in-four-prostate-cancer-active-surveillance-cohorts
#20
Lurdes Y T Inoue, Daniel W Lin, Lisa F Newcomb, Amy S Leonardson, Donna Ankerst, Roman Gulati, H Ballentine Carter, Bruce J Trock, Peter R Carroll, Matthew R Cooperberg, Janet E Cowan, Laurence H Klotz, Alexandre Mamedov, David F Penson, Ruth Etzioni
Background: Active surveillance (AS) is increasingly accepted for managing low-risk prostate cancer, yet there is no consensus about implementation. This lack of consensus is due in part to uncertainty about risks for disease progression, which have not been systematically compared or integrated across AS studies with variable surveillance protocols and dropout to active treatment. Objective: To compare risks for upgrading from a Gleason score (GS) of 6 or less to 7 or more across AS studies after accounting for differences in surveillance intervals and competing treatments and to evaluate tradeoffs of more versus less frequent biopsies...
November 28, 2017: Annals of Internal Medicine
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