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Active surveillance prostate

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https://www.readbyqxmd.com/read/29469937/radiomic-features-on-mri-enable-risk-categorization-of-prostate-cancer-patients-on-active-surveillance-preliminary-findings
#1
Ahmad Algohary, Satish Viswanath, Rakesh Shiradkar, Soumya Ghose, Shivani Pahwa, Daniel Moses, Ivan Jambor, Ronald Shnier, Maret Böhm, Anne-Maree Haynes, Phillip Brenner, Warick Delprado, James Thompson, Marley Pulbrock, Andrei S Purysko, Sadhna Verma, Lee Ponsky, Phillip Stricker, Anant Madabhushi
BACKGROUND: Radiomic analysis is defined as computationally extracting features from radiographic images for quantitatively characterizing disease patterns. There has been recent interest in examining the use of MRI for identifying prostate cancer (PCa) aggressiveness in patients on active surveillance (AS). PURPOSE: To evaluate the performance of MRI-based radiomic features in identifying the presence or absence of clinically significant PCa in AS patients. STUDY TYPE: Retrospective...
February 22, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29468607/the-patient-reported-information-multidimensional-exploration-prime-framework-for-investigating-emotions-and-other-factors-of-prostate-cancer-patients-with-low-intermediate-risk-based-on-online-cancer-support-group-discussions
#2
Tharindu Bandaragoda, Weranja Ranasinghe, Achini Adikari, Daswin de Silva, Nathan Lawrentschuk, Damminda Alahakoon, Raj Persad, Damien Bolton
BACKGROUND: This study aimed to use the Patient Reported Information Multidimensional Exploration (PRIME) framework, a novel ensemble of machine-learning and deep-learning algorithms, to extract, analyze, and correlate self-reported information from Online Cancer Support Groups (OCSG) by patients (and partners of patients) with low intermediate-risk prostate cancer (PCa) undergoing radical prostatectomy (RP), external beam radiotherapy (EBRT), and active surveillance (AS), and to investigate its efficacy in quality-of-life (QoL) and emotion measures...
February 21, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29463549/androgen-deprivation-therapy-potentiates-the-efficacy-of-vascular-targeted-photodynamic-therapy-of-prostate-cancer-xenografts
#3
Kwanghee Kim, Philip A Watson, Souhil Lebdai, Sylvia Jebiwott, Alexander Somma, Stephen P La Rosa, Dipti Mehta, Katie S Murray, Hans G Lilja, David Ulmert, Sebastien Monette, Avigdor J Scherz, Jonathan Coleman
PURPOSE: WST11 vascular targeted photodynamic therapy (VTP) is a local ablation approach relying upon rapid, free radical-mediated destruction of tumor vasculature. A phase III trial showed that VTP significantly reduced disease progression when compared to active surveillance in patients with low-risk prostate cancer (PCa). The aim of this study was to identify a druggable pathway that could be combined with VTP to improve its efficacy and applicability to higher risk PCa tumors. EXPERIMENTAL DESIGN: Transcriptome analysis of VTP treated tumors (LNCaP-AR xenografts) was used to identify a candidate pathway for combination therapy...
February 20, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29456621/men-seeking-counselling-in-a-breast-cancer-risk-evaluation-clinic
#4
Ana Catarina Freitas, Ana Opinião, Sofia Fragoso, Hugo Nunes, Madalena Santos, Ana Clara, Sandra Bento, Ana Luis, Jorge Silva, Cecília Moura, Bruno Filipe, Patrícia Machado, Sidónia Santos, Saudade André, Paula Rodrigues, Joana Parreira, Fátima Vaz
Background: Hereditary breast and ovary cancer syndrome affects both genders but little is known about the uptake of genetic services by men. The objective of this study is to characterise the male population counselled through a multidisciplinary breast/ovarian program. Methods: Descriptive analysis of male patients counselled from January 2000 to December 2015. Data in this analysis include new cancer diagnoses during prospective follow up. Results: From 4,320 families registered, 362 male patients were identified: 236 (65...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29454590/understanding-how-prostate-cancer-patients-value-the-current-treatment-options-for-metastatic-castration-resistant-prostate-cancer
#5
Tarik Benidir, Karen Hersey, Antonio Finelli, Rob Hamilton, Anthony M Joshua, Girish Kulkarni, Alexandre Zlotta, Neil Fleshner
Several new compounds are now available for castration resistant prostate cancer (CRPC). Individual costs range between $40,000 and $93,000 with mean survival extensions from 2.4 to 4.8 months. Currently, it remains unclear how patients with prostate cancer (PCa) value the effect of these therapies in the setting of CRPC. OBJECTIVE: To assess patient understanding of core cancer concepts, opinions on the cost and overall benefit of CRPC drugs, whether out-of-pocket costs would change opinions and whether patients would ultimately opt out of CRPC drug treatment for an end-of-life (EOL) premium...
February 14, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29438586/progression-and-treatment-rates-using-an-active-surveillance-protocol-incorporating-image-guided-baseline-biopsies-and-multi-parametric-mri-monitoring-for-men-with-favourable-risk-prostate-cancer
#6
David Thurtle, Tristan Barrett, Vineetha Thankappan-Nair, Brendan Koo, Anne Warren, Christof Kastner, Kasra Saeb-Parsy, Jenna Kimberley-Duffell, Vincent J Gnanapragasam
OBJECTIVE: To assess early outcomes since the introduction of an active surveillance (AS) protocol incorporating mpMRI guided baseline biopsies and image based surveillance. PATIENTS AND METHODS: A new AS protocol mandating image-guided baseline biopsies, annual mpMRI and 3 monthly PSA but which retained protocol re-biopsies was tested. Pathological progression, treatment conversion and triggers for non-protocol biopsy were recorded prospectively. RESULTS: Data from 157 men enrolled on this protocol (median: age 64years, PSA 6...
February 13, 2018: BJU International
https://www.readbyqxmd.com/read/29433975/refined-analysis-of-prostate-specific-antigen-kinetics-to-predict-prostate-cancer-active-surveillance-outcomes
#7
Matthew R Cooperberg, James D Brooks, Anna V Faino, Lisa F Newcomb, James T Kearns, Peter R Carroll, Atreya Dash, Ruth Etzioni, Michael D Fabrizio, Martin E Gleave, Todd M Morgan, Peter S Nelson, Ian M Thompson, Andrew A Wagner, Daniel W Lin, Yingye Zheng
BACKGROUND: For men on active surveillance for prostate cancer, utility of prostate-specific antigen (PSA) kinetics (PSAk) in predicting pathologic reclassification remains controversial. OBJECTIVE: To develop prediction methods for utilizing serial PSA and evaluate frequency of collection. DESIGN, SETTING, AND PARTICIPANTS: Data were collected from men enrolled in the multicenter Canary Prostate Active Surveillance Study, for whom PSA data were measured and biopsies performed on prespecified schedules...
February 9, 2018: European Urology
https://www.readbyqxmd.com/read/29433973/role-of-surveillance-biopsy-with-no-cancer-as-a-prognostic-marker-for-reclassification-results-from-the-canary-prostate-active-surveillance-study
#8
James T Kearns, Anna V Faino, Lisa F Newcomb, James D Brooks, Peter R Carroll, Atreya Dash, William J Ellis, Michael Fabrizio, Martin E Gleave, Todd M Morgan, Peter S Nelson, Ian M Thompson, Andrew A Wagner, Yingye Zheng, Daniel W Lin
BACKGROUND: Many patients who are on active surveillance (AS) for prostate cancer will have surveillance prostate needle biopsies (PNBs) without any cancer evident. OBJECTIVE: To define the association between negative surveillance PNBs and risk of reclassification on AS. DESIGN, SETTING, AND PARTICIPANTS: All men were enrolled in the Canary Prostate Active Surveillance Study (PASS) between 2008 and 2016. Men were included if they had Gleason ≤3+4 prostate cancer and <34% core involvement ratio at diagnosis...
February 9, 2018: European Urology
https://www.readbyqxmd.com/read/29425377/quality-of-life-among-men-with-low-risk-prostate-cancer-during-the-first-year-following-diagnosis-the-prepare-prospective-cohort-study
#9
Kathryn L Taylor, George Luta, Richard M Hoffman, Kimberly M Davis, Tania Lobo, Yingjun Zhou, Amethyst Leimpeter, Jun Shan, Roxanne E Jensen, David S Aaronson, Stephen K Van Den Eeden
As many as 40% of men diagnosed with prostate cancer have low-risk disease, which results in the need to decide whether to undergo active treatment (AT) or active surveillance (AS). The treatment decision can have a significant effect on general and prostate-specific quality of life (QOL). The purpose of this study was to assess the QOL among men with low-risk prostate cancer during the first year following diagnosis. In a prospective cohort study, we conducted pretreatment telephone interviews (N = 1,139; 69...
February 7, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29420980/mr-imaging-for-prostate-cancer-screening-and-active-surveillance
#10
REVIEW
Sasha C Druskin, Katarzyna J Macura
The current prostate cancer management paradigm has been criticized in recent years for contributing to the overdiagnosis and overtreatment of the disease. Active surveillance is an avenue by which to reduce overtreatment, but patient selection and monitoring remain a challenge. The use of prostate MR imaging has been growing in recent years and has been incorporated into prostate cancer screening and patient selection and monitoring for active surveillance. This review article discusses the current evidence for the use of MR imaging in each of those settings...
March 2018: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/29409845/initial-experience-performing-in-office-ultrasound-guided-transperineal-prostate-biopsy-under-local-anesthesia-using-the-precisionpoint-transperineal-access-system
#11
Alexa R Meyer, Gregory A Joice, Zeyad R Schwen, Alan W Partin, Mohamad E Allaf, Michael A Gorin
OBJECTIVE: To describe our procedural technique and initial outcomes performing in-office transperineal prostate biopsies using the PrecisionPoint Transperineal Access System. PATIENTS AND METHODS: Following Institutional Review Board approval, we retrospectively reviewed the records of men who underwent an in-office transperineal prostate biopsy using the PrecisionPoint device. Records were reviewed for baseline characteristics, biopsy results, and post-biopsy complications...
January 31, 2018: Urology
https://www.readbyqxmd.com/read/29406053/prostate-cancer-screening
#12
REVIEW
William J Catalona
During the prostate-specific antigen-based prostate cancer (PCa) screening era there has been a 53% decrease in the US PCa mortality rate. Concerns about overdiagnosis and overtreatment combined with misinterpretation of clinical trial data led to a recommendation against PCa screening, resulting in a subsequent reversion to more high-risk disease at diagnosis. Re-evaluation of trial data and increasing acceptance of active surveillance led to a new draft recommendation for shared decision making for men aged 55 to 69 years old...
March 2018: Medical Clinics of North America
https://www.readbyqxmd.com/read/29401514/patient-and-provider-experiences-with-active-surveillance-a-scoping-review
#13
Claire Kim, Frances C Wright, Nicole J Look Hong, Gary Groot, Lucy Helyer, Pamela Meiers, May Lynn Quan, Robin Urquhart, Rebecca Warburton, Anna R Gagliardi
OBJECTIVE: Active surveillance (AS) represents a fundamental shift in managing select cancer patients that initiates treatment only upon disease progression to avoid overtreatment. Given uncertain outcomes, patient engagement could support decision-making about AS. Little is known about how to optimize patient engagement for AS decision-making. This scoping review aimed to characterize research on patient and provider communication about AS, and associated determinants and outcomes. METHODS: MEDLINE, EMBASE, CINAHL, and The Cochrane Library were searched from 2006 to October 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29395386/our-experience-in-the-management-of-prostate-cancer-in-renal-transplant-recipients
#14
A Narváez, J Suarez, L Riera, M Castells-Esteve, R Cocera, F Vigués
INTRODUCTION AND OBJECTIVES: The management of Prostate cancer (PCa) in renal transplant recipients (RTR) is challenging and remain controversial. Currently there is no consensus about this condition. The aim of the study was to analyse our experience in the diagnosis and management of PCa in RTR. METHOD: Retrospective monocentric study of a prospective and consecutive database from 2003-2017. Inclusion of RTR diagnosed of PCa. Staging and treatment in agreement with the contemporary guidelines...
January 26, 2018: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29391368/predicting-prostate-cancer-progression-protocol-for-a-retrospective-cohort-study-to-identify-prognostic-factors-for-prostate-cancer-outcomes-using-routine-primary-care-data
#15
Samuel W D Merriel, Margaret T May, Richard M Martin
INTRODUCTION: Prostate cancer is the most common cancer in men in the UK, with nearly 40 000 diagnosed in 2014; and it is the second most common cause of male cancer-related mortality. The clinical conundrum is that most men live with prostate cancer rather than die from it, while existing treatments have significant associated morbidity. Recent studies have shown very low mortality rates (1% after a median of 10-year follow-up) and no treatment-related reductions in mortality, in men with localised prostate cancer...
January 31, 2018: BMJ Open
https://www.readbyqxmd.com/read/29373215/focal-therapy-in-primary-localised-prostate-cancer-the-european-association-of-urology-position-in-2018
#16
Henk G van der Poel, Roderick C N van den Bergh, Erik Briers, Philip Cornford, Alex Govorov, Ann M Henry, Thomas B Lam, Malcolm D Mason, Olivier Rouvière, Maria De Santis, Peter-Paul M Willemse, Hendrik van Poppel, Nicolas Mottet
Radical treatment of localised prostate cancer is recognised to be an unnecessary intervention or overtreatment in many men. Consequently, there has been a rapid uptake in the use of focal ablative therapies. However, there are several biological and practical concerns about such approaches as they have yet to be proved as robust treatment options. In particular, the multifocal nature of prostate cancer argues against unifocal treatment, while limitations in imaging can preclude the accurate identification of the number, location, and extent of prostate cancer foci...
January 17, 2018: European Urology
https://www.readbyqxmd.com/read/29373089/multiparametric-mr-imaging-of-the-prostate-after-treatment-of-prostate-cancer
#17
Pritesh Patel, Melvy S Mathew, Igor Trilisky, Aytekin Oto
The use of multiparametric magnetic resonance (MR) imaging in prostate cancer therapy is increasing, as newer treatment methods and management approaches emerge. The mainstays of therapy-radiation and surgery-are being supplemented (and even replaced) by novel focal therapy methods. Laser and ultrasonographic ablation, photodynamic therapy, electroporation, and cryoablation are the most common focal therapies, each with its own imaging findings. Typical ablation zones have a central focus of enhancement with peripheral rim enhancement; thus, dynamic contrast material-enhanced (DCE) MR imaging is the most important sequence for evaluation of treatment in the immediate posttherapeutic setting...
January 26, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29371727/role-of-multi-parametric-mp-mri-in-prostate-cancer
#18
Syed Muhammad Nazim, Muhammad Hammad Ather, Basit Salam
Multi-parametric magnetic resonance imaging is increasingly being recommended as standard imaging modality for prostate cancer diagnosis and staging. It comprises structural T2 and T1 sequences supplemented by functional imaging techniques, i.e. diffusion-weighted, dynamic contrast enhanced and spectroscopic imaging. Pre-biopsy multi-parametric magnetic resonance imaging is recommended for both detection and staging as it avoids biopsy artefact, and when normal, has a negative predictive value of 95% for significant cancer...
January 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29370650/re-padeliporfin-vascular-targeted-photodynamic-therapy-versus-active-surveillance-in-men-with-low-risk-prostate-cancer-clin1001-pcm301-an-open-label-phase-3-randomised-controlled-trial
#19
https://www.readbyqxmd.com/read/29368876/clinical-and-pathologic-factors-predicting-reclassification-in-active-surveillance-cohorts
#20
Pablo S Sierra, Shivashankar Damodaran, David Jarrard
The incidence of small, lower risk well-differentiated prostate cancer is increasing and almost half of the patients with this diagnosis are candidates for initial conservative management in an attempt to avoid overtreatment and morbidity associated with surgery or radiation. A proportion of patients labeled as low risk, candidates for Active Surveillance (AS), harbor aggressive disease and would benefit from definitive treatment. The focus of this review is to identify clinicopathologic features that may help identify these less optimal AS candidates...
January 26, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
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