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Active surveillance prostate

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https://www.readbyqxmd.com/read/28208525/re-active-surveillance-of-prostate-cancer-in-a-community-practice-how-to-measure-manage-and-improve
#1
David F Penson
No abstract text is available yet for this article.
March 2017: Journal of Urology
https://www.readbyqxmd.com/read/28208519/re-quantified-clinical-risk-change-as-an-end-point-during-prostate-cancer-active-surveillance
#2
Samir S Taneja
No abstract text is available yet for this article.
March 2017: Journal of Urology
https://www.readbyqxmd.com/read/28196367/clinical-factors-predicting-tumour-upgrading-in-patients-under-active-surveillance-and-elected-to-active-treatment-after-disease-reclassification-or-progression
#3
Antonio Benito Porcaro, Francesca Cavicchioli, Nicolò De Luyk, Daniele Mattevi, Paolo Corsi, Marco Sebben, Alessandro Tafuri, Tania Processali, Davide Inverardi, Giovanni Cacciamani, Davide De Marchi, Matteo Balzarro, Maria A Cerruto, Matteo Brunelli, Giovanni Novella, Salvatore Siracusano, Walter Artibani
OBJECTIVES: To evaluate clinical factors associated with tumour upgrading (UPG) in low-intermediate risk patients who progressed while under active surveillance (AS) and underwent delayed radical prostatectomy. MATERIAL AND METHODS: The evaluated factors included prostate specific antigen (PSA), prostate volume, PSA density and number of biopsy positive cores (BPC). Multivariate logistic regression by the forward step Wald procedure was used. RESULTS: The study evaluated 24 patients who had UPG in 13 cases (54...
February 14, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28192399/c-met-mir-130b-axis-as-novel-mechanism-and-biomarker-for-castration-resistance-state-acquisition
#4
A Cannistraci, G Federici, A Addario, A L Di Pace, L Grassi, G Muto, D Collura, M Signore, L De Salvo, S Sentinelli, G Simone, M Costantini, S Nanni, A Farsetti, V Coppola, R De Maria, D Bonci
Although a significant subset of prostate tumors remain indolent during the entire life, the advanced forms are still one of the leading cause of cancer-related death. There are not reliable markers distinguishing indolent from aggressive forms. Here we highlighted a new molecular circuitry involving microRNA and coding genes promoting cancer progression and castration resistance. Our preclinical and clinical data demonstrated that c-Met activation increases miR-130b levels, inhibits androgen receptor expression, promotes cancer spreading and resistance to hormone ablation therapy...
February 13, 2017: Oncogene
https://www.readbyqxmd.com/read/28186627/value-of-three-section-contrast-enhanced-transrectal-ultrasonography-in-the-detection-of-prostate-cancer
#5
Ting-Yue Qi, Hong-Guang Sun, Nian-Fen Li, Hao Feng, Yong-Ling Ding, Xiao-Xiang Wang
BACKGROUND: To assess the efficacy of three-section contrast-enhanced transrectal ultrasonography (CETRUS) in prostate cancer (PCa) detection. METHODS: A total of 169 consecutive patients with either PSA level ≥ 4 ng/ml or abnormal digital rectal examination findings were prospectively enrolled in this single center study. All patients underwent baseline transrectal ultrasonography (TRUS) and three-section CETRUS by one investigator blinded to any clinical data before TRUS-guided transperineal biopsy...
February 10, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28178275/phase-of-care-prevalence-for-prostate-cancer-in-new-south-wales-australia-a-population-based-modelling-study
#6
Xue Qin Yu, Qingwei Luo, David P Smith, Mark S Clements, Manish I Patel, Dianne L O'Connell
OBJECTIVE: To develop a method for estimating the future numbers of prostate cancer survivors requiring different levels of care. DESIGN, SETTING AND PARTICIPANTS: Analysis of population-based cancer registry data for prostate cancer cases (aged 18-84 years) diagnosed in 1996-2007, and a linked dataset with hospital admission data for men with prostate cancer diagnosed during 2005-2007 in New South Wales (NSW), Australia. METHODS: Cancer registry data (1996-2007) were used to project complete prostate cancer prevalence in NSW, Australia for 2008-2017, and treatment information from hospital records (2005-2007) was used to estimate the inpatient care needs during the first year after diagnosis...
2017: PloS One
https://www.readbyqxmd.com/read/28168601/long-term-follow-up-after-active-surveillance-or-curative-treatment-quality-of-life-outcomes-of-men-with-low-risk-prostate-cancer
#7
Lionne D F Venderbos, Shafak Aluwini, Monique J Roobol, Leonard P Bokhorst, Eric H G M Oomens, Chris H Bangma, Ida J Korfage
PURPOSE: To compare long-term (4-10 years) quality of life (QoL) of men with low-risk prostate cancer (PCa) treated by different modalities and a reference group without PCa. METHODS: In this cross-sectional study, four groups were sent a one-time QoL-questionnaire; PCa patients (1) following the structured Prostate cancer Research International Active Surveillance protocol, (2) who underwent radical prostatectomy (RP) in the context of the European Randomized study of Screening for Prostate Cancer-section Rotterdam, (3) who underwent radiotherapy (RT) at an academic hospital in The Netherlands, and (4) an age-matched reference group of men without PCa...
February 6, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28162816/active-surveillance-discussion-for-low-risk-prostate-cancer-patients-preferences-and-counseling-techniques
#8
EDITORIAL
Ardalan E Ahmad, Antonio Finelli
No abstract text is available yet for this article.
February 2, 2017: European Urology
https://www.readbyqxmd.com/read/28161349/obesity-as-a-risk-factor-for-unfavorable-disease-in-low-risk-prostate-cancer-and-its-relationship-with-anatomic-location-of-tumor
#9
In Gab Jeong, Sangjun Yoo, Chunwoo Lee, Myong Kim, Dalsan You, Cheryn Song, Sungchan Park, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
PURPOSE: To investigate the influence of obesity on unfavorable disease in low-risk prostate cancer eligible for active surveillance and verify the underlying relationship with tumor location. MATERIALS AND METHODS: We analyzed 890 patients with biopsy Gleason score 6 who underwent radical prostatectomy for prostate cancer via multicore (≥12) biopsy at our institution. Unfavorable disease was defined as primary Gleason pattern ≥4 or pathologic stage ≥T3. Multivariate logistic regression analysis was performed to identify factors associated with unfavorable disease...
February 1, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28159497/intermediate-and-longer-term-outcomes-from-a-prospective-active-surveillance-program-for-favorable-risk-prostate-cancer-tosoian-jj-mamawala-m-epstein-ji-landis-p-wolf-s-trock-bj-carter-hb-j-clin-oncol-2015-oct-20-33-30-3379-85-epub-2015-aug-31-doi-10-1200-jco
#10
Eggener Scott, M Mamawala, J I Epstein, P Landis, S Wolf, Trock, H B Carter
PURPOSE: To assess long-term outcomes of men with favorable-risk prostate cancer in a prospective, active surveillance program. METHODS: Curative intervention was recommended for disease reclassification to higher cancer grade or volume on prostate biopsy. Primary outcomes were overall, cancer-specific, and metastasis-free survival. Secondary outcomes were the cumulative incidence of reclassification and curative intervention. Factors associated with grade reclassification and curative intervention were evaluated in a Cox proportional hazards model...
March 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28152858/prostate-cancer-care-in-canada-informed-decision-making-patterns-of-care-and-treatment-trends
#11
Rami Rahal, Carolyn Sandoval, Geoff Porter, Sharon Fung, Cheryl Louzado, Julie Xu, Heather E Bryant
: 289 Background: Because treatment options for localized prostate cancer (PCa) have similar survival outcomes but varying side effects, it is important that patients are meaningfully involved in the decision-making process to ensure the chosen treatment aligns with their needs, wants and preferences. Here, we describe PCa patients' experience with informed decision-making as well as treatment patterns and trends over time. METHODS: Focus groups were conducted with 47 men treated for PCa across Canada to understand their cancer journey experience...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28145675/active-surveillance-for-localized-prostate-cancer-no-increased-mortality-but-higher-rates-of-clinical-progression
#12
Mark H Ebell
No abstract text is available yet for this article.
February 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28144285/the-presence-of-primary-circulating-prostate-cells-is-associated-with-upgrading-and-upstaging-in-patients-eligible-for-active-surveillance
#13
Nigel P Murray, Eduardo Reyes, Cynthia Fuentealba, Socrates Aedo, Omar Jacob
: Active surveillance (AS) is a considered treatment option for men with low or very low-risk prostate cancer. However, on repeat biopsy some 25% were upgraded and recommended for active treatment. We compare the presence or absence of primary circulating prostate cells (CPCs) with the clinical pathological findings after radical prostatectomy in men fulfilling the criteria for active surveillance and the risk of reclassification for active observation (AO). METHODS AND PATIENTS: A single centre observational study was done involving 102 men who fulfilled the Epstein criteria for AS and underwent radical prostatectomy as mono-therapy for prostate cancer...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28140460/factors-predicting-prostate-cancer-upgrading-on-magnetic-resonance-imaging-targeted-biopsy-in-an-active-surveillance-population
#14
Win Shun Lai, Jennifer B Gordetsky, John V Thomas, Jeffrey W Nix, Soroush Rais-Bahrami
BACKGROUND: The objective of this study was to create a nomogram model integrating clinical and multiparametric magnetic resonance imaging (MP-MRI)-based variables to predict prostate cancer upgrading in a population of active surveillance (AS) patients. METHODS: Prostate cancer patients on AS who underwent MP-MRI with magnetic resonance imaging (MRI)/ultrasound (US) fusion-guided biopsy were identified. Clinical and imaging variables, including the prostate-specific antigen density (PSAD), number of lesions, total lesion volume, total lesion density, Prostate Imaging Reporting and Data System magnetic resonance imaging suspicion score (MRI-SS), and duration between prereferral systematic and MRI/US fusion-guided biopsy sessions, were assessed...
January 31, 2017: Cancer
https://www.readbyqxmd.com/read/28129893/a-systematic-approach-to-discussing-active-surveillance-with-patients-with-low-risk-prostate-cancer
#15
Behfar Ehdaie, Melissa Assel, Nicole Benfante, Deepak Malhotra, Andrew Vickers
BACKGROUND: Physicians report difficulty convincing patients with prostate cancer about the merits of active surveillance (AS); as a result, a majority of patients unnecessarily choose to undergo radical treatment. OBJECTIVE: To develop and evaluate a systematic approach for physicians to counsel patients with low-risk prostate cancer to increase acceptance of AS. DESIGN, SETTING, AND PARTICIPANTS: A systematic counseling approach was developed and piloted in one clinic...
January 24, 2017: European Urology
https://www.readbyqxmd.com/read/28126301/exploring-value-from-the-patient-s-perspective-between-modern-radiation-therapy-modalities-for-localized-prostate-cancer
#16
Narek Shaverdian, Darlene Verruttipong, Pin-Chieh Wang, Amar U Kishan, D Jeffrey Demanes, Susan McCloskey, Patrick Kupelian, Michael L Steinberg, Christopher R King
PURPOSE: Patients' perspectives on their treatment experiences have not been compared between modern radiation modalities for localized prostate cancer. We evaluated treatment regret and patients' perceptions of their treatment experiences to better inform our understanding of a treatment's value. METHODS AND MATERIALS: Patients with localized prostate cancer treated with stereotactic body radiation therapy (SBRT), intensity modulated radiation therapy (IMRT), or high-dose-rate (HDR) brachytherapy between 2008 and 2014 with at least 1 year of follow-up were surveyed...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28124869/reducing-the-rate-of-biopsy-gleason-undergrading-may-not-improve-biochemical-recurrence-rates-in-active-surveillance-candidates
#17
Roderick C VAN DEN Bergh, Homayoun Zargar, Stijn Heijmink, Mike Bozin, Declan G Murphy, Henk G VAN DER Poel
BACKGROUND: To explore the impact of improved risk stratification on biochemical recurrence (BCR) rates after surgery in prostate cancer (PC) patients also suitable for active surveillance (AS). Patients with Gleason upgrading were compared to those who were correctly graded with biopsy. Also, to analyze whether AS criteria may be expanded, by comparing patients outside the AS criteria without Gleason upgrading, to men eligible for AS. METHODS: Low-risk PC was widely defined as clinically organ-confined and biopsy Gleason score =<3+3=6...
January 26, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28124394/treatment-decision-making-in-early-stage-papillary-thyroid-cancer
#18
Thomas A D'Agostino, Elyse Shuk, Erin K Maloney, Rebecca Zeuren, R Michael Tuttle, Carma L Bylund
OBJECTIVE: The purpose of this study was to develop an in-depth understanding of papillary microcarcinoma (PMC) patients' decision-making process when offered options of surgery and active surveillance. METHODS: 15 PMC patients and six caregivers participated in either a focus group or individual interview. Focus groups were segmented by patients' treatment choice. Primary themes were identified in transcripts using thematic text analysis. RESULTS: Four themes emerged from the surgery subsample: (1) Decision to undergo thyroidectomy quickly and with a sense of urgency; (2) Perception of PMC as a potentially life-threatening disease; (3) Fear of disease progression and unremitting uncertainty with active surveillance; and (4) Surgery as a means of control and potential cure...
January 26, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28119368/gleason-score-7-prostate-cancers-emerge-through-branched-evolution-of-clonal-gleason-pattern-3-and-4
#19
Adam G Sowalsky, Haydn T Kissick, Sean Gerrin, Rachel Schaefer, Zheng Xia, Joshua Russo, Mohamed S Arredouani, Glenn J Bubley, Martin G Sanda, Wei Li, Huihui Ye, Steven P Balk
PURPOSE: The molecular features that account for the distinct histology and aggressive biological behavior of Gleason pattern 4 (Gp4) versus Gp3 prostate cancer (PCa), and whether Gp3 tumors progress directly to Gp4, remain to be established. EXPERIMENTAL DESIGN: Whole exome sequencing and transcriptome profiling of laser-capture microdissected adjacent Gp3 and cribiform Gp4 were used to determine the relationship between these entities. RESULTS: Sequencing confirmed that adjacent Gp3 and Gp4 were clonal based on multiple shared genomic alterations...
January 24, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28110975/a-prospective-study-of-health-related-quality-of-life-outcomes-for-patients-with-low-risk-prostate-cancer-managed-by-active-surveillance-or-radiation-therapy
#20
John S Banerji, Lauren M Hurwitz, Jennifer Cullen, Erika M Wolff, Katherine E Levie, Inger L Rosner, Timothy C Brand, James O LʼEsperance, Joseph R Sterbis, Christopher R Porter
INTRODUCTION: Patients with low-risk prostate cancer (PCa) often have excellent oncologic outcomes. However, treatment with curative intent can lead to decrements in health-related quality of life (HRQoL). Patients treated with radical prostatectomy have been shown to suffer declines in urinary and sexual HRQoL as compared to those managed with active surveillance (AS). Similarly, patients treated with external-beam radiation therapy (EBRT) are hypothesized to experience greater declines in bowel HRQoL...
January 19, 2017: Urologic Oncology
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