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orthostatic tremor

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https://www.readbyqxmd.com/read/27713855/orthostatic-tremor-an-update-on-a-rare-entity
#1
Julián Benito-León, Ángela Domingo-Santos
BACKGROUND: Orthostatic tremor (OT) remains among the most intriguing and poorly understood of movement disorders. Compared to Parkinson's disease or even essential tremor, there are very few articles addressing more basic science issues. In this review, we will discuss the findings of main case series on OT, including data on etiology, pathophysiology, diagnostic approach, treatment strategies, and outcome. METHODS: Data for this review were identified by searching PUBMED (January 1966 to August 2016) for the terms "orthostatic tremor" or "shaky leg syndrome," which yielded 219 entries...
2016: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/27631243/in-vivo-neurometabolic-profiling-in-orthostatic-tremor
#2
Julián Benito-León, Elan D Louis, Virginia Mato-Abad, Ulrike Dydak, Juan Álvarez-Linera, Juan Antonio Hernández-Tamames, José Antonio Molina-Arjona, Norberto Malpica, Michele Matarazzo, Juan Pablo Romero, Álvaro Sánchez-Ferro
The pathogenesis of orthostatic tremor (OT) remains unclear, although some evidence points to dysfunction in the brainstem or cerebellum. We used single voxel proton magnetic resonance spectroscopy (1H-MRS) (3 T) to investigate whether neurochemical changes underlie abnormal cerebellar or cortical function in OT. Fourteen OT patients and 14 healthy controls underwent 1H-MRS studies with voxels placed in midparietal gray matter and cerebellum (vermis and central white matter). Spectral analysis was analyzed using the software package LCModel (version 6...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27522355/long-term-follow-up-of-chronic-spinal-cord-stimulation-for-medically-intractable-orthostatic-tremor
#3
Christian Blahak, Tamara Sauer, Hansjoerg Baezner, Marc E Wolf, Assel Saryyeva, Christoph Schrader, Hans-Holger Capelle, Michael G Hennerici, Joachim K Krauss
Orthostatic tremor (OT) is a rare form of tremor occurring in the legs when standing upright. Medical treatment frequently is unsatisfactory, thus in selected cases, surgical treatment, such as spinal cord stimulation (SCS) or thalamic deep brain stimulation has been proposed. We report the long-term results (follow-up (FU) 34-133 months) of SCS in four patients with medically intractable OT. Outcome was assessed by recording the time tolerated to stand still pre- and post-operatively and by a patient self-rating (PSR) scale (0 = poor to 6 = excellent)...
November 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27495202/diagnosis-and-management-of-tremor
#4
Elan D Louis
PURPOSE OF REVIEW: Tremor, which is a rhythmic oscillation of a body part, is among the most common involuntary movements. Rhythmic oscillations may manifest in a variety of ways; as a result, a rich clinical phenomenology surrounds tremor. For this reason, diagnosing tremor disorders can be particularly challenging. The aim of this article is to provide the reader with a straightforward approach to the diagnosis and management of patients with tremor. RECENT FINDINGS: Scientific understanding of the pathophysiologic basis of tremor disorders has grown considerably in recent years with the use of a broad range of neuroimaging approaches and rigorous, controlled postmortem studies...
August 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27457226/cerebello-cortical-networks-in-orthostatic-tremor
#5
Muthuraman Muthuraman, Sergiu Groppa, Günter Deuschl
No abstract text is available yet for this article.
August 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27442678/resting-state-functional-mri-reveals-abnormal-network-connectivity-in-orthostatic-tremor
#6
Julián Benito-León, Elan D Louis, Eva Manzanedo, Juan Antonio Hernández-Tamames, Juan Álvarez-Linera, José Antonio Molina-Arjona, Michele Matarazzo, Juan Pablo Romero, Cristina Domínguez-González, Ángela Domingo-Santos, Álvaro Sánchez-Ferro
Very little is known about the pathogenesis of orthostatic tremor (OT). We have observed that OT patients might have deficits in specific aspects of neuropsychological function, particularly those thought to rely on the integrity of the prefrontal cortex, which suggests a possible involvement of frontocerebellar circuits. We examined whether resting-state functional magnetic resonance imaging (fMRI) might provide further insights into the pathogenesis on OT. Resting-state fMRI data in 13 OT patients (11 women and 2 men) and 13 matched healthy controls were analyzed using independent component analysis, in combination with a "dual-regression" technique, to identify group differences in several resting-state networks (RSNs)...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27432180/orthostatic-tremor-clinical-electrophysiologic-and-treatment-findings-in-184-patients
#7
Julián Benito-León, Angela Domingo-Santos, Anhar Hassan, J Eric Ahlskog, Joseph Y Matsumoto, James H Bower
No abstract text is available yet for this article.
July 19, 2016: Neurology
https://www.readbyqxmd.com/read/27401947/the-clinical-symptoms-of-parkinson-s-disease
#8
Sigurlaug Sveinbjornsdottir
In this review, the clinical features of Parkinson's disease, both motor and non-motor, are described in the context of the progression of the disease. Also briefly discussed are the major treatment strategies and their complications. Parkinson's disease is a slowly progressing neurodegenerative disorder, causing impaired motor function with slow movements, tremor and gait and balance disturbances. A variety of non-motor symptoms are common in Parkinson's disease. They include disturbed autonomic function with orthostatic hypotension, constipation and urinary disturbances, a variety of sleep disorders and a spectrum of neuropsychiatric symptoms...
October 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27329770/orthostatic-tremor-a-cerebellar-pathology
#9
Cécile Gallea, Traian Popa, Daniel García-Lorenzo, Romain Valabregue, André-Pierre Legrand, Emmanuelle Apartis, Lea Marais, Bertrand Degos, Cecile Hubsch, Sara Fernández-Vidal, Eric Bardinet, Emmanuel Roze, Stéphane Lehéricy, Sabine Meunier, Marie Vidailhet
SEE MUTHURAMAN ET AL DOI101093/AWW164 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Primary orthostatic tremor is characterized by high frequency tremor affecting the legs and trunk during the standing position. Cerebellar defects were suggested in orthostatic tremor without direct evidence. We aimed to characterize the anatomo-functional defects of the cerebellar motor pathways in orthostatic tremor. We used multimodal neuroimaging to compare 17 patients with orthostatic tremor and 17 age- and gender-matched healthy volunteers...
August 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27254274/deep-brain-stimulation-for-the-treatment-of-hyperkinetic-movement-disorders
#10
Lazzaro di Biase, Renato Puppi Munhoz
INTRODUCTION: Deep brain stimulation effectiveness is well recognized for different movement disorders including Parkinson's disease, dystonia and essential tremor, however several other diseases in this field may benefit from the technique although experience is sparse and evidences of benefit and risks are not established. AREAS COVERED: In this review, we explored available evidence for effectiveness and safety of DBS in selected hyperkinetic movement disorders, including tardive dyskinesia, Huntington's disease, neuroacanthocytosis, myoclonus-dystonia, Tourette syndrome, orthostatic and Holmes' tremor...
September 2016: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/27002536/bilateral-ventral-intermediate-nucleus-thalamic-deep-brain-stimulation-in-orthostatic-tremor
#11
Robert R Coleman, Philip A Starr, Maya Katz, Graham A Glass, Monica Volz, Suketu M Khandhar, Jill L Ostrem
BACKGROUND: Orthostatic tremor (OT) is characterized by high-frequency leg tremor when standing still, resulting in a sense of imbalance, with limited treatment options. Ventral intermediate (Vim) nucleus thalamic deep brain stimulation (DBS) has been reported as beneficial in a few cases. OBJECTIVE: To report clinical outcomes, lead locations, and stimulation parameters in 2 patients with severe medication-refractory OT treated with Vim DBS. METHODS: The patients underwent surface electromyography (EMG) to confirm the OT diagnosis...
2016: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/26985048/unusual-tremor-syndromes-know-in-order-to-recognise
#12
Robert J Ure, Sanveer Dhanju, Anthony E Lang, Alfonso Fasano
Tremor is a common neurological condition in clinical practice; yet, few syndromes are widely recognised and discussed in the literature. As a result, there is an overdiagnosis of well-known causes, such as essential tremor. Many important unusual syndromes should be considered in the differential diagnosis of patients with tremor. The objective of this review is to provide broad clinical information to aid in the recognition and treatment of various unusual tremor syndromes in the adult and paediatric populations...
November 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/26916904/four-cases-of-orthostatic-myoclonus
#13
Z Aldaajani, F C F Chang, S D Kim, N Mahant, V S C Fung
Orthostatic unsteadiness (unsteadiness on standing) is a relatively common symptom and can have neurological or non-neurological causes. Glass et al. have recently described a syndrome presenting with unsteadiness or leg jerking during standing or gait initiation difficulty which they have termed orthostatic myoclonus (OM). OM is a disabling syndrome but potentially treatable. It may develop on the background of neurodegenerative disease; other causes include pro-myoclonic drugs such as tricyclic antidepressants...
July 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/26877891/dystonia-associated-with-idiopathic-slow-orthostatic-tremor
#14
Christopher Kobylecki, Monty A Silverdale, Jeremy P R Dick, Mark W Kellett, Andrew G Marshall
BACKGROUND: We aimed to characterize the clinical and electrophysiological features of patients with slow orthostatic tremor. CASE REPORT: The clinical and neurophysiological data of patients referred for lower limb tremor on standing were reviewed. Patients with symptomatic or primary orthostatic tremor were excluded. Eight patients were identified with idiopathic slow 4-8 Hz orthostatic tremor, which was associated with tremor and dystonia in cervical and upper limb musculature...
2015: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/26810532/cognitive-and-neuropsychiatric-features-of-orthostatic-tremor-a-case-control-comparison
#15
Julián Benito-León, Elan D Louis, Verónica Puertas-Martín, Juan Pablo Romero, Michele Matarazzo, José Antonio Molina-Arjona, Cristina Domínguez-González, Álvaro Sánchez-Ferro
INTRODUCTION: Evidence suggests that the cerebellum could play a role in the pathophysiology of orthostatic tremor. The link between orthostatic tremor and the cerebellum is of interest, especially in light of the role the cerebellum plays in cognition, and it raises the possibility that orthostatic tremor patients could have cognitive deficits consistent with cerebellar dysfunction. Our aim was to examine whether orthostatic tremor patients had cognitive deficits and distinct personality profiles when compared with matched controls...
February 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/26795196/serotonin-1a-receptors-on-astrocytes-as-a-potential-target-for-the-treatment-of-parkinson-s-disease
#16
Ikuko Miyazaki, Masato Asanuma
Astrocytes are the most abundant neuron-supporting glial cells in the central nervous system. The neuroprotective role of astrocytes has been demonstrated in various neurological disorders such as amyotrophic lateral sclerosis, spinal cord injury, stroke and Parkinson's disease (PD). Astrocyte dysfunction or loss-of-astrocytes increases the susceptibility of neurons to cell death, while astrocyte transplantation in animal studies has therapeutic advantage. We reported recently that stimulation of serotonin 1A (5-HT1A) receptors on astrocytes promoted astrocyte proliferation and upregulated antioxidative molecules to act as a neuroprotectant in parkinsonian mice...
2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/26788354/spinal-generated-movement-disorders-a-clinical-review
#17
REVIEW
Pichet Termsarasab, Thananan Thammongkolchai, Steven J Frucht
Spinal-generated movement disorders (SGMDs) include spinal segmental myoclonus, propriospinal myoclonus, orthostatic tremor, secondary paroxysmal dyskinesias, stiff person syndrome and its variants, movements in brain death, and painful legs-moving toes syndrome. In this paper, we review the relevant anatomy and physiology of SGMDs, characterize and demonstrate their clinical features, and present a practical approach to the diagnosis and management of these unusual disorders.
2015: Journal of Clinical Movement Disorders
https://www.readbyqxmd.com/read/26788343/cortical-tremor-ct-with-coincident-orthostatic-movements
#18
Pichet Termsarasab, Steven J Frucht
Cortical tremor (CT) is a form of cortical reflex myoclonus that can mimic essential tremor (ET). Clinical features that are helpful in distinguishing CT from ET are the irregular and jerky appearance of the movements. We report two patients with CT with coexisting orthostatic movements, either orthostatic tremor (OT) or myoclonus, who experienced functional improvement in both cortical myoclonus and orthostatic movements when treated with levetiracetam.
2015: Journal of Clinical Movement Disorders
https://www.readbyqxmd.com/read/26765757/secondary-orthostatic-tremor-in-the-setting-of-cerebellar-degeneration
#19
Harini Sarva, William Lawrence Severt, Nuri Jacoby, Seth L Pullman, Rachel Saunders-Pullman
Orthostatic tremor (OT) and cerebellar ataxia are uncommon and difficult to treat. We present two patients with OT and cerebellar degeneration, one of whom had spinocerebellar ataxia type 2 and a good treatment response.
May 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/26754283/-orthostatic-tremor-a-cause-of-dizziness
#20
C Magro Fernández, E Durán Ferreras, P Peña Guerrero, A Caballero Romera
No abstract text is available yet for this article.
January 2, 2016: Semergen
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