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https://www.readbyqxmd.com/read/28334438/insurance-denials-for-cancer-clinical-trial-participation-after-the-affordable-care-act-mandate
#1
Christine B Mackay, Kaitlyn R Antonelli, Suanna S Bruinooge, Jarron M Saint Onge, Shellie D Ellis
BACKGROUND: The Affordable Care Act (ACA) includes a mandate requiring most private health insurers to cover routine patient care costs for cancer clinical trial participation; however, the impact of this provision on cancer centers' efforts to accrue patients to clinical trials has not been well described. METHODS: First, members of cancer research centers and community-based institutions (n = 252) were surveyed to assess the status of insurance denials, and then, a focused survey (n = 77) collected denial details...
March 23, 2017: Cancer
https://www.readbyqxmd.com/read/28328015/pcsk9-inhibitor-access-barriers-issues-and-recommendations-improving-the-access-process-for-patients-clinicians-and-payers
#2
REVIEW
Seth J Baum, Peter P Toth, James A Underberg, Paul Jellinger, Joyce Ross, Katherine Wilemon
The proprotein convertase subtilisin/kexin type 9 inhibitors or monoclonal antibodies likely represent the greatest advance in lipid management in 30 years. In 2015 the US Food and Drug Administration approved both alirocumab and evolocumab for high-risk patients with familial hypercholesterolemia (FH) and clinical atherosclerotic cardiovascular disease requiring additional lowering of low-density lipoprotein cholesterol. Though many lipid specialists, cardiovascular disease prevention experts, endocrinologists, and others prescribed the drugs on label, they found their directives denied 80% to 90% of the time...
March 22, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28327212/more-stereotypes-please-the-limits-of-theory-of-mind-and-the-need-for-further-studies-on-the-complexity-of-real-world-social-interactions
#3
Kristin Andrews
I suggest that the Stereotype Rationality Hypothesis (Jussim 2012) is only partially right. I agree it is rational to rely on stereotypes, but in the complexity of real world social interactions, most of our individuating information invokes additional stereotypes. Despite assumptions to the contrary, there is reason to think theory of mind is not accurate, and social psychology's denial of stereotype accuracy led us toward mindreading/theory of mind - a less accurate account of how we understand other people...
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28325386/-identifying-a-child-in-danger-during-a-consultation-in-the-emergency-department
#4
REVIEW
Patricia Vasseur
Child abuse is a public health issue. Many abused children present physical injuries which could be picked up in emergency departments. Caregivers must therefore be particularly vigilant from the moment the child arrives. Some reluctance to report potential abuse, notably due to denial or to being overly cautious can place the child in irreversible danger.
March 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28300479/knowing-and-not-knowing-a-frequent-human-arrangement
#5
Sylvia Solinski
The paradigmatic system of societal abuse occurs in totalitarian state systems. The relational systems of subjugation that maintain such states of terror must, of necessity, destroy any authentic civic space in which individuals can flourish. Similar dynamics characterize child abuse within families. Survival requires the use of varied strategies, the most extreme of which are dissociative in nature, and that result in marked distortions of developmental trajectories across all psychological domains. Such dynamics are mirrored in dissociative systems that, in the absence of intervention, perpetuate the trauma of non-recognition by subjugation and self-objectification, or by omnipotent denial of others' subjectivity...
February 23, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28288387/can-we-make-a-portrait-of-women-with-inoperable-locally-advanced-breast-cancer
#6
Giacomo Montagna, Andres R Schneeberger, Lorenzo Rossi, Gabriella Bianchi Micheli, Francesco Meani, Mauro Imperiali, Alessandra Spitale, Olivia Pagani
INTRODUCTION: Delay between clinical presentation and treatment of breast cancer (BC) can significantly impact mortality. We aimed at drawing a picture of women with locally advanced breast cancer (LABC) treated at our Breast Unit and at investigating factors associated with treatment delay. MATERIAL AND METHODS: A retrospective descriptive analysis, using a specific 28-item semi-structured questionnaire, was conducted in 67 patients diagnosed with T4 BC. RESULTS: Nearly a third of our patients had at least one known predisposing factor for LABC...
March 10, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28285304/men-s-views-on-depression-a-systematic-review-and-metasynthesis-of-qualitative-research
#7
Silvia Krumm, Carmen Checchia, Markus Koesters, Reinhold Kilian, Thomas Becker
BACKGROUND: According to the concept of "male depression," depression among men might be underdiagnosed and undertreated because of gender differences in symptoms and coping. There is evidence that men experience atypical depressive symptoms including irritability, aggression, substance abuse, and increased risk behavior. To date, a substantial number of qualitative studies on men's views on depression has been conducted in the last few decades. METHODS: Based on a systematic review and metasynthesis of qualitative studies on men's subjective perspectives on depression, we aim at a comprehensive understanding of men's subjective views on depression with a specific focus on masculinity constructions...
March 11, 2017: Psychopathology
https://www.readbyqxmd.com/read/28282962/a-novel-topology-link-controlling-approach-for-active-defense-of-a-node-in-a-network
#8
Jun Li, HanPing Hu, Qiao Ke, Naixue Xiong
With the rapid development of virtual machine technology and cloud computing, distributed denial of service (DDoS) attacks, or some peak traffic, poses a great threat to the security of the network. In this paper, a novel topology link control technique and mitigation attacks in real-time environments is proposed. Firstly, a non-invasive method of deploying virtual sensors in the nodes is built, which uses the resource manager of each monitored node as a sensor. Secondly, a general topology-controlling approach of resisting the tolerant invasion is proposed...
March 9, 2017: Sensors
https://www.readbyqxmd.com/read/28281921/lateralization-of-neurobiological-response-in-adolescents-with-post-traumatic-stress-disorder-related-to-severe-childhood-sexual-abuse-the-tri-modal-reaction-t-mr-model-of-protection
#9
Tuba Mutluer, Vedat Şar, Çiğdem Kose-Demiray, Harun Arslan, Sibel Tamer, Serap Inal, Anıl Ş Kaçar
This study inquires into neurobiological response to stress and its clinical correlates among adolescents with post-traumatic stress disorder (PTSD). Structural magnetic resonance imaging (MRI) measures of cerebral anatomy were carried out on 23 female adolescents with PTSD related to severe childhood sexual abuse and 21 matched healthy controls. Clinician Administered PTSD Scale for Children and Adolescents, Adolescent Dissociative Experiences Scale, Childhood Trauma Questionnaire, Schedule for Affective Disorders and Schizophrenia for School Age Children, Beck Depression Scale and a set of neuro-cognitive tests were administered to all participants...
March 10, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28280492/mitochondrial-complex-v-%C3%AE-subunit-is-critical-for-candida-albicans-pathogenicity-through-modulating-multiple-virulence-properties
#10
Shui-Xiu Li, Yan-Jun Song, Yi-Shan Zhang, Hao-Tian Wu, Hui Guo, Kun-Ju Zhu, Dong-Mei Li, Hong Zhang
The α subunit (ATP1) is a vital component of mitochondrial complex V which counts for the majority of cellular ATP production in a living organism. Nevertheless, how the α subunit influences other cellular processes such as pathogenicity in Candida albicans remains poorly understood. To address this question, ATP1 mutant (atp1Δ/Δ) and the gene-reconstituted strain (atp1Δ/ATP1) have been constructed in this study and their pathogenicity-related traits are compared to those of wild type (WT). In a murine model of disseminated candidiasis, atp1Δ/Δ infected mice have a significantly higher survival rate and experience a lower fungal burden in tissues...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28277812/considerations-on-bringing-warehoused-hcv-patients-into-active-care-following-interferon-free-direct-acting-antiviral-drug-approval
#11
Aleksandra Palak, Christine Livoti, Céline Audibert
OBJECTIVES: Until recently, lack of efficacious and tolerable hepatitis C virus (HCV) treatments prompted patient warehousing until better treatment options became available. We investigated whether the introduction of ledipasvir/sofosbuvir precipitated patient return to clinics, thereby changing HCV clinic dynamics. METHODS: Online questionnaire responses indicated the volume of HCV patients followed, the proportion of warehoused patients and those who were proactively offered new options, methods for identifying and contacting patients, and insurance authorization/reimbursement-related information...
March 9, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28271970/patient-reluctance-to-discuss-pain-understanding-stoicism-stigma-and-other-contributing-factors
#12
John Cagle, Morgan Bunting
Some patients are hesitant to disclose when they are experiencing pain. However, the reasons for this, such as stoicism and concern about being a bother to others, are poorly understood. If patient pain goes unrecognized during clinical encounters, patients may also be at greater risk for pain-related crises, use of hospice/palliative care on-call services, and in-patient transfers. This is an evidence-informed development of a practice-oriented conceptual model to understand and address patient reluctance to admit pain...
January 2017: Journal of Social Work in End-of-life & Palliative Care
https://www.readbyqxmd.com/read/28266320/different-functioning-of-prefrontal-cortex-predicts-treatment-response-after-a-selective-serotonin-reuptake-inhibitor-treatment-in-patients-with-major-depression
#13
Koji Masuda, Mari Nakanishi, Kana Okamoto, Chiwa Kawashima, Harumi Oshita, Ayako Inoue, Fuku Takita, Toshihiko Izumi, Yoshinobu Ishitobi, Haruka Higuma, Masayuki Kanehisa, Taiga Ninomiya, Yoshinori Tanaka, Jotaro Akiyoshi
BACKGROUND: Major depressive disorder (MDD) is often resistant to treatment with usual approaches. Patients with MDD have shown hypofunction of the frontotemporal cortex in verbal fluency test (VFT)-related near-infrared spectroscopy (NIRS). METHODS: We examined whether the reactions to drug treatment in treatment-naive patients with MDD could be predicted by NIRS outcomes at the initial investigation. All subjects underwent psychological testing to determine levels of anxiety and depression...
March 4, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28259212/is-the-new-heroin-epidemic-really-new-racializing-heroin
#14
Benjamin Bowser, Robert Fullilove, Carl Word
Heroin abuse as an outcome of the prior use of painkillers increased rapidly over the past decade. This "new epidemic" is unique because the new heroin users are primarily young White Americans in rural areas of virtually every state. This commentary argues that the painkiller-to-heroin transition could not be the only cause of heroin use on such a scale and that the new and old heroin epidemics are linked. The social marketing that so successfully drove the old heroin epidemic has innovated and expanded due to the use of cell-phones, text messaging and the "dark web" which requires a Tor browser, and software that allows one to communicate with encrypted sites without detection...
April 2017: Journal of the National Medical Association
https://www.readbyqxmd.com/read/28249865/stress-and-coping-of-critical-care-nurses-after-unsuccessful-cardiopulmonary-resuscitation
#15
Dawn E McMeekin, Ronald L Hickman, Sara L Douglas, Carol G Kelley
BACKGROUND: Participation by a critical care nurse in an unsuccessful resuscitation can create a unique heightened level of psychological stress referred to as postcode stress, activation of coping behaviors, and symptoms of posttraumatic stress disorder (PTSD). OBJECTIVES: To explore the relationships among postcode stress, coping behaviors, and PTSD symptom severity in critical care nurses after experiencing unsuccessful cardiopulmonary resuscitations and to see whether institutional support attenuates these repeated psychological traumas...
March 2017: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/28240770/digest-prudent-self-denial-the-advantage-of-incompatibility-in-leavenworthia-alabamica
#16
Alex Harkness
Molecular self-incompatibility systems in angiosperms at first appear to be evolutionary paradoxes. These systems, which reject self-pollen before it can fertilize an ovule, have persisted for long evolutionary periods. One such system was likely inherited from the common ancestor of core eudicots 110 million years ago (Igić and Kohn 2001). However, self-incompatibility is far more frequently lost than gained. Furthermore, the complexity of these systems makes it improbable for them to be regained once lost...
February 27, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28239195/who-is-the-scientist-subject-a-critique-of-the-neo-kantian-scientist-subject-in-lorraine-daston-and-peter-galison-s-objectivity
#17
REVIEW
Esha Shah
The main focus of this essay is to closely engage with the role of scientist-subjectivity in the making of objectivity in Lorraine Daston and Peter Galison's book Objectivity, and Daston's later and earlier works On Scientific Observation and The Moral Economy of Science. I have posited four challenges to the neo-Kantian and Foucauldian constructions of the co-implication of psychology and epistemology presented in these texts. Firstly, following Jacques Lacan's work, I have argued that the subject of science constituted by the mode of modern science suffers from paranoia...
2017: Minerva
https://www.readbyqxmd.com/read/28214468/difficulties-experienced-by-veterinarians-when-communicating-about-emerging-zoonotic-risks-with-animal-owners-the-case-of-hendra-virus
#18
Diana H Mendez, Petra Büttner, Jenny Kelly, Madeleine Nowak, Rick Speare Posthumously
BACKGROUND: Communication skills are essential for veterinarians who need to discuss animal health related matters with their clients. When dealing with an emerging zoonosis, such as Hendra virus (HeV), veterinarians also have a legal responsibility to inform their clients about the associated risks to human health. Here we report on part of a mixed methods study that examined the preparedness of, and difficulties experienced by, veterinarians communicating about HeV-related risks with their clients...
February 18, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28210340/the-relationship-between-stress-and-coping-in-table-tennis
#19
Dora Kurimay, Alison Pope-Rhodius, Miran Kondric
The aim of this study was to examine the relationship between cognitive competitive anxiety intensity and coping strategies in table tennis players. One hundred and two (102) US competitive table tennis players of age range from 10 to 60 filled out a Revised Competitive State Anxiety Inventory-2 (CSAI-2R, Cox et al., 2003) at least 30 minutes before the start of their tournament match and a Modified Cope questionnaire (MCOPE; Crocker and Graham, 1995) 15 minutes after they finished their match. Our study found significant differences between low and high cognitive competitive anxiety groups with regard to the use of coping strategies...
January 1, 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28207426/psychological-characteristics-of-early-stage-melanoma-patients-a-cross-sectional-study-on-204-patients
#20
Valentina Tesio, Simone Ribero, Lorys Castelli, Stefania Bassino, Paolo Leombruni, Virginia Caliendo, Marcella Grassi, Danilo Lauro, Giuseppe Macripò, Riccardo G V Torta
The presence of psychological distress has a negative impact not only on cancer patients' quality of life but also on the course of the disease, with slower recovery and increased morbidity. These issues are of particular importance in melanoma patients (MP), who remain at risk of disease progression for many years after diagnosis. This study aimed to investigate psychological distress, coping strategies, and their possible relationships with demographic-clinical features in patients with early-stage melanoma in follow-up...
February 15, 2017: Melanoma Research
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