Panagiotis Flamée, Varnavas Varnavas, Wendy Dewals, Hugo Carvalho, Wilfried Cools, Jigme Tshering Bhutia, Stefan Beckers, Vincent Umbrain, Christian Verborgh, Patrice Forget, Gian-Battista Chierchia, Pedro Brugada, Jan Poelaert, Carlo de Asmundis
BACKGROUND: Brugada Syndrome is an inherited arrhythmogenic disease, characterized by the typical coved type ST-segment elevation in the right precordial leads from V1 through V3. The BrugadaDrugs.org Advisory Board recommends avoiding administration of propofol in patients with Brugada Syndrome. Since prospective studies are lacking, it was the purpose of this study to assess the electrocardiographic effects of propofol and etomidate on the ST- and QRS-segments. In this trial, it was hypothesized that administration of propofol or etomidate in bolus for induction of anesthesia, in patients with Brugada Syndrome, do not clinically affect the ST- and QRS-segments and do not induce arrhythmias...
March 2020: Anesthesiology