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https://www.readbyqxmd.com/read/28429208/ultra-low-dose-periradicular-infiltration-of-the-lumbar-spine-spot-scanning-and-its-potential-for-further-dose-reduction-by-replacing-helical-planning-ct
#1
Fabian Henry Jürgen Elsholtz, Lars-Arne Schaafs, Christoph Erxleben, Bernd Hamm, Stefan Markus Niehues
PURPOSE: Computed tomography (CT)-guided periradicular infiltration has become an accepted procedure for treating radiculopathy-associated low back pain. The purpose of this study is to compare spot scanning and segmental helical planning CT in terms of dose reduction. MATERIALS AND METHODS: Eighty-five patients underwent CT-guided single-site lumbar periradicular therapy. Prior imaging was not available for planning. Sixty-three patients were examined with a new dedicated spot scanning technique (group I), and twenty-two patients underwent conventional segmental planning CT examinations with helical image acquisition serving as controls (group II)...
April 20, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28422837/multilevel-cervical-disc-replacement-versus-multilevel-anterior-discectomy-and-fusion-a-meta-analysis
#2
Ting-Kui Wu, Bei-Yu Wang, Yang Meng, Chen Ding, Yi Yang, Ji-Gang Lou, Hao Liu
BACKGROUND: Cervical disc replacement (CDR) has been developed as an alternative surgical procedure to anterior cervical discectomy and fusion (ACDF) for the treatment of single-level cervical degenerative disc disease. However, patients with multilevel cervical degenerative disc disease (MCDDD) are common in our clinic. Multilevel CDR is less established compared with multilevel ACDF. This study aims to compare the outcomes and evaluate safety and efficacy of CDR versus ACDF for the treatment of MCDDD...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28422796/waterless-hand-rub-versus-traditional-hand-scrub-methods-for-preventing-the-surgical-site-infection-in-orthopaedic-surgery
#3
Kentaro Iwakiri, Akio Kobayashi, Masahiko Seki, Yoshiyuki Ando, Tadao Tsujio, Masatoshi Hoshino, Hiroaki Nakamura
STUDY DESIGN: A retrospective cohort study with prospectively collected data OBJECTIVE.: The aim of this study was to compare SSI incidences, the cost of hand hygiene agents, and hand hygiene time between the traditional hand scrub and the waterless hand rub protocols before orthopaedic surgery. SUMMARY OF BACKGROUND DATA: Surgical-site-infections (SSI) prolong hospitalization and are a leading nosocomial cause of morbidity as well as a source of excess cost. Recently, a waterless hand rub protocol comprising alcohol based chlorhexidine gluconate for use before surgery was developed, but no studies have yet examined its utility in orthopaedic surgery...
April 18, 2017: Spine
https://www.readbyqxmd.com/read/28420102/efficient-actor-recovery-paradigm-for-wireless-sensor-and-actor-networks
#4
Reem K Mahjoub, Khaled Elleithy
The actor nodes are the spine of wireless sensor and actor networks (WSANs) that collaborate to perform a specific task in an unverified and uneven environment. Thus, there is a possibility of high failure rate in such unfriendly scenarios due to several factors such as power consumption of devices, electronic circuit failure, software errors in nodes or physical impairment of the actor nodes and inter-actor connectivity problem. Therefore, it is extremely important to discover the failure of a cut-vertex actor and network-disjoint in order to improve the Quality-of-Service (QoS)...
April 14, 2017: Sensors
https://www.readbyqxmd.com/read/28399557/radiological-results-and-clinical-patient-outcome-after-implantation-of-a-hydraulic-expandable-vertebral-body-replacement-following-traumatic-vertebral-fractures-in-the-thoracic-and-lumbar-spine-a-3-year-follow-up
#5
Michael Kreinest, Dorothee Schmahl, Paul A Grützner, Stefan Matschke
STUDY DESIGN: A prospective monocentric study. OBJECTIVE: The aim of the current study was the analysis of patient outcome and radiological results 3 years after implantation of a hydraulic expandable vertebral body replacement (VBR) system. SUMMARY OF BACKGROUND DATA: Around 70% to 90% of all traumatic spinal fractures are located in the thoracic and lumbar spine. Dorso-ventral stabilization is a frequently used procedure in traumatic vertebral body fracture treatment...
April 15, 2017: Spine
https://www.readbyqxmd.com/read/28387616/long-term-clinical-and-radiographic-outcomes-of-the-prestige-lp-artificial-cervical-disc-replacement-at-2-levels-results-from-a-prospective-randomized-controlled-clinical-trial
#6
Todd H Lanman, J Kenneth Burkus, Randall G Dryer, Matthew F Gornet, Jeffrey McConnell, Scott D Hodges
OBJECTIVE The aim of this study was to assess long-term clinical safety and effectiveness in patients undergoing anterior cervical surgery using the Prestige LP artificial disc replacement (ADR) prosthesis to treat degenerative cervical spine disease at 2 adjacent levels compared with anterior cervical discectomy and fusion (ACDF). METHODS A prospective, randomized, controlled, multicenter FDA-approved clinical trial was conducted at 30 US centers, comparing the low-profile titanium ceramic composite-based Prestige LP ADR (n = 209) at 2 levels with ACDF (n = 188)...
April 7, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28387560/clinical-evaluation-of-the-concussed-athlete-a-view-from-the-sideline
#7
Margot Putukian
CONTEXT: The sideline assessment of concussion is challenging, given its variable presentations, the limited sensitivity and specificity of sideline assessment tools, and how the presentation of the injury evolves over time. In addition, the diagnostic process, as well as the tools used to assess and manage concussion, continue to progress as research and what we know about concussion advance. This paper focuses on the initial assessment on the sideline by reviewing the concussion-evaluation literature, drawing from clinical experience to emphasize a standardized approach, and underscoring the importance of both familiarity with the athlete and clinical judgment...
March 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28383779/factors-influencing-preoperative-urinary-calcium-excretion-in-primary-hyperparathyroidism
#8
Reto Martin Kaderli, Philipp Riss, Angelika Geroldinger, Andreas Selberherr, Christian Scheuba, Bruno Niederle
OBJECTIVE: Normal or elevated 24-hour urinary calcium (Ca) excretion is a diagnostic marker in primary hyperparathyroidism (PHPT). It is used to distinguish familial hypocalciuric hypercalcaemia (FHH) from PHPT by calculating the Ca/creatinine clearance ratio (CCCR). The variance of CCCR in patients with PHPT is considerable. The aim of the present study was to analyse the parameters affecting CCCR in patients with PHPT. DESIGN: The data were collected prospectively...
April 6, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28377865/regional-variations-in-shear-strength-and-density-of-the-human-thoracic-vertebral-endplate-and-trabecular-bone
#9
Fred Xavier, Julio J Jauregui, Nathan Cornish, Rebecca Jason-Rousseau, Dipal Chatterjee, Gavriel Feuer, Westley Hayes, Bhaveen H Kapadia, John N Carter, Hiroyuki Yoshihara, Subrata Saha
BACKGROUND: Previous studies investigated the overall mechanical strength of the vertebral body; however, limited information is available on the biomechanical properties of different regions within the vertebral endplate and cancellous bone. In addition, the correlation between mechanical strength and various density measurements has not been studied yet. METHODS: Thoracic (T10) vertebrae were harvested from fifteen human cadaveric spines (average age: 77 years old)...
2017: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/28376754/fat-in-the-lumbar-multifidus-muscles-predictive-value-and-change-following-disc-prosthesis-surgery-and-multidisciplinary-rehabilitation-in-patients-with-chronic-low-back-pain-and-degenerative-disc-2-year-follow-up-of-a-randomized-trial
#10
Kjersti Storheim, Linda Berg, Christian Hellum, Øivind Gjertsen, Gesche Neckelmann, Ansgar Espeland, Anne Keller
BACKGROUND: Evidence is lacking on whether fat infiltration in the multifidus muscles affects outcomes after total disc replacement (TDR) surgery and if it develops after surgery. The aims of this study were 1) to investigate whether pre-treatment multifidus muscle fat infiltration predicts outcome 2 years after treatment with TDR surgery or multidisciplinary rehabilitation, and 2) to compare changes in multifidus muscle fat infiltration from pre-treatment to 2-year follow-up between the two treatment groups...
April 4, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28374228/milk-and-dairy-consumption-and-risk-of-cardiovascular-diseases-and-all-cause-mortality-dose-response-meta-analysis-of-prospective-cohort-studies
#11
Jing Guo, Arne Astrup, Julie A Lovegrove, Lieke Gijsbers, David I Givens, Sabita S Soedamah-Muthu
With a growing number of prospective cohort studies, an updated dose-response meta-analysis of milk and dairy products with all-cause mortality, coronary heart disease (CHD) or cardiovascular disease (CVD) have been conducted. PubMed, Embase and Scopus were searched for articles published up to September 2016. Random-effect meta-analyses with summarised dose-response data were performed for total (high-fat/low-fat) dairy, milk, fermented dairy, cheese and yogurt. Non-linear associations were investigated using the spine models and heterogeneity by subgroup analyses...
April 3, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28373138/the-influence-of-spine-hip-relations-on-total-hip-replacement-a-systematic-review
#12
REVIEW
C Rivière, J-Y Lazennec, C Van Der Straeten, E Auvinet, J Cobb, S Muirhead-Allwood
Sagittal pelvic kinematics along with spino-pelvic angular parameters have recently been studied by numerous investigators for their effect on total hip replacement (THR) clinical outcomes, but many issue of spine-hip relations (SHR) are currently unexplored. Therefore, our review aims at clarifying the following questions: is there any evidence of a relationship between articular impingement/dislocation risk in primary THR and (1) certain sagittal pelvic kinematics patterns, (2) pelvic incidence, and (3) types of SHRs? A systematic review of the existing literature utilising PubMed and Google search engines was performed in January 2017...
April 1, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28368469/older-men-with-anemia-have-increased-fracture-risk-independent-of-bone-mineral-density
#13
Rodrigo J Valderrábano, Jennifer Lee, Li-Yung Lui, Andrew R Hoffman, Steven R Cummings, Eric S Orwoll, Joy Y Wu
Context: Extreme low hemoglobin values have been linked to increased risk of fracture at different sites in a small number of studies. However, careful assessment of a clinically relevant cutoff for anemia and cross sectional and longitudinal bone mineral density (BMD) measures is lacking. Objective: To determine whether men with anemia were at increased risk of fracture after accounting for bone density and bone loss. Design: Cross-sectional analysis (at visit 3) and prospective analysis (from baseline to visit 3) in the Osteoporotic Fractures in Men (MrOS), a multi-site longitudinal cohort study...
March 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28364146/bundled-payments-in-total-joint-arthroplasty-and-spine-surgery
#14
REVIEW
Rashad Sullivan, Landry D Jarvis, Tadhg O'Gara, Maxwell Langfitt, Cynthia Emory
PURPOSE OF REVIEW: The goal of this manuscript is to provide an overview and analysis of bundled payment models for joint replacement and select spine procedures. Advantages and disadvantages of bundled payment models will be discussed. RECENT FINDINGS: In select populations, bundled payment models have been shown to reduce costs while maintaining satisfactory outcomes. These models have not been tested with complex patient cohorts, such as older adults with fragility hip fractures, and limited data exist with bundled payment analysis in spine procedures...
March 31, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28356913/posterior-cord-syndrome-and-trace-elements-deficiency-as-an-uncommon-presentation-of-common-variable-immunodeficiency
#15
Yuri Silva Macedo, Ananda Dos Santos Mota, Priscila Morais Monteiro, Angela Cristina Gouvêa Carvalho, Barbara Fernandes Diniz, Pedro Gemal Lanzieri, Ricardo Carneiro Ramos, Luis Otavio Mocarzel, Ronaldo Altenburg Gismondi
Diarrhea is one of the most common symptoms in common variable immunodeficiency, but neurologic manifestations are rare. We presented a 50-year-old woman with recurrent diarrhea and severe weight loss that developed a posterior cord syndrome. Endoscopy found a duodenal villous blunting, intraepithelial lymphocytosis, and lack of plasma cells and magnetic resonance imaging of the spine was normal. Laboratory assays confirmed common variable immunodeficiency syndrome and showed low levels of trace elements (copper and zinc)...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28350950/spine-oncology-metastatic-spine-tumors
#16
David Choi, Mark Bilsky, Michael Fehlings, Charles Fisher, Ziya Gokaslan
Surgery for spinal metastases remains the mainstay treatment for pain, instability, and neurological deterioration due to tumor infiltration of the spine. However, several new therapies are emerging which may improve outcomes further, and in some cases even replace the need for surgery. We now have a better understanding of which factors influence survival and quality of life after surgery, and this underpins the development and application of new treatments, and assessment of outcome.Depending on genetic subtyping of tumors, novel immunotherapies and chemotherapies may be very effective in prolonging quality of life...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28340364/cervical-facet-force-analysis-after-disc-replacement-versus-fusion
#17
Vikas V Patel, Zachary R Wuthrich, Kirk C McGilvray, Matthew C Lafleur, Emily M Lindley, Derrick Sun, Christian M Puttlitz
BACKGROUND: Cervical total disc replacement was developed to preserve motion and reduce adjacent-level degeneration relative to fusion, yet concerns remain that total disc replacement will lead to altered facet joint loading and long-term facet joint arthrosis. This study is intended to evaluate changes in facet contact force, pressure and surface area at the treated and superior adjacent levels before and after discectomy, disc replacement, and fusion. METHODS: Ten fresh-frozen human cadaveric cervical spines were potted from C2 to C7 with pressure sensors placed into the facet joints of C3-C4 and C4-C5 via slits in the facet capsules...
March 18, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28337729/adjacent-level-disease-background-and-update-based-on-disc-replacement-data
#18
REVIEW
I David Kaye, Alan S Hilibrand
PURPOSE OF REVIEW: The precise etiology of adjacent segment disease following cervical spine surgery is controversial. Theories for development include inevitable changes secondary to the natural progression of the degenerative cascade and changes secondary to altered biomechanics of the fused cervical spine. Motion preserving techniques, such as cervical disc arthroplasties (CDA), have been introduced with the hopes of reducing the rates of adjacent segment pathology. Recently, 7-year data from the investigational device exemption (IDE) studies have been published...
March 23, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28331187/cross-beta-nanostructures-based-on-dinaphthylalanine-gd-conjugates-loaded-with-doxorubicin
#19
Carlo Diaferia, Eliana Gianolio, Teresa Sibillano, Flavia Anna Mercurio, Marilisa Leone, Cinzia Giannini, Nicole Balasco, Luigi Vitagliano, Giancarlo Morelli, Antonella Accardo
Very recently we proposed novel di- and tetra-phenylalanine peptides derivatized with gadolinium complexes as potentials supramolecular diagnostic agents for applications in MRI (Magnetic Resonance Imaging). It was observed that in very short FF dipeptide building blocks, the propensity to aggregate decreases significantly after modification with bulky moiety such as Gd-complexes, thus limiting their potential as CAs. We hypothesized that the replacement of the Phe side chain with more extended aromatic groups could improve the self-assembling...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28326305/implications-for-a-stem-cell-regenerative-medicine-based-approach-to-human-intervertebral-disk-degeneration
#20
REVIEW
Petra Kraus, Thomas Lufkin
The human body develops from a single cell, the zygote, the product of the maternal oocyte and the paternal spermatozoon. That 1-cell zygote embryo will divide and eventually grow into an adult human which is comprised of ~3.7 × 10(13) cells. The tens of trillions of cells in the adult human can be classified into approximately 200 different highly specialized cell types that make up all of the different tissues and organs of the human body. Regenerative medicine aims to replace or restore dysfunctional cells, tissues and organs with fully functional ones...
2017: Frontiers in Cell and Developmental Biology
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