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Spine replacement

Maria Oliveira, James Fraser McConnell, Thomas W Maddox, Daniel Sanchez-Masian, Rita Gonçalves
The constructive interference in steady state (CISS) sequence has been widely used in human neuroimaging. It has been shown to be advantageous in the evaluation of intra-axial and extra-axial cystic abnormalities, arteriovenous and dysraphic malformations and disturbances of cerebrospinal fluid circulation. To assess the utility of this technique in small animals, interpretations based on this sequence were compared with those based on T2-weighted (T2W) sequences in 145 dogs that underwent MRI of the spine for suspected spinal cord disease...
March 14, 2018: Veterinary Record
Dominik Baschera, Joachim Oberle, Florian Grubhofer, Samuel Luca Schmid
BACKGROUND AND STUDY AIMS:  Perioperative use of anticoagulant and platelet-inhibiting agents by patients undergoing spine surgery poses the dilemma of increased risk of hemorrhage. We examined the standards of use for these medications and expert opinions through a nationwide survey. MATERIALS AND METHODS:  An online-based survey was conducted by invitation. A personal token to access the survey was sent to one representative of each neurosurgical and orthopaedic unit performing spine surgery and to all other active members of the Swiss Society of Neurosurgery and the Swiss Society of Spinal Surgery...
March 9, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
Antonella Accardo, Carlo Diaferia, Nicole Balasco, Teresa Sibillano, Moumita Ghosh, Lihi Adler-Abramovich, Cinzia Giannini, Luigi Vitagliano, Giancarlo Morelli
Phenylalanine-based nanostructures have attracted the attention of the material science community for their functional properties. These properties depend on the hierarchic organization of the nanostructure that in turn can be finely tuned by punctual chemical modifications of the building blocks. Here, we investigate how the partial or the complete replacement of the Phe residues with tyrosine ones (PEG8-(FY)3 or PEG8-Y6) in the parental PEG8-F6 can alter the structure of the nanomaterials. The effect of the PEG derivatization was also evaluated in peptides without the PEG moiety (Y6 and (FY)3)...
March 5, 2018: Chemistry: a European Journal
Chun-Kun Park, Kyeong-Sik Ryu
Since the launch of cervical total disc replacement (CTDR) in the early 2000s, many clinical studies have reported better outcomes of CTDR compared to those of anterior cervical discectomy and fusion. However, CTDR is still a new and innovative procedure with limited indications for clinical application in spinal surgery, particularly, for young patients presenting with soft disc herniation with radiculopathy and/or myelopathy. In addition, some controversial issues related to the assessment of clinical outcomes of CTDR remain unresolved...
February 2018: Asian Spine Journal
Elodie Degroote, Halil Yildiz, Frederic Lecouvet, Alexia Verroken, Leila Belkhir
OBJECTIVE AND IMPORTANCE: New methods of microbiology identification as MALDI-TOF MS increased the rate of Aerococci detection in microbiological samples making this germ an emerging pathogen. The purpose of this case report and literature review is to highlight the role of A. urinae in spine infection and discuss the management of this type of infection. CLINICAL PRESENTATION AND INTERVENTION: A 32-year-old man, with a medical history of paraplegia secondary to a relapsing form of multiple sclerosis, was admitted because of lower back-pain following complaints suggestive of urinary tract infection...
March 2, 2018: Acta Clinica Belgica
Adam E M Eltorai, Wesley M Durand, Jack M Haglin, Lee E Rubin, Arnold-Peter C Weiss, Alan H Daniels
Understanding trends in reimbursement is critical to the financial sustainability of orthopedic practices. Little research has examined physician fee trends over time for orthopedic procedures. This study evaluated trends in Medicare reimbursements for orthopedic surgical procedures. The Medicare Physician Fee Schedule was examined for Current Procedural Terminology code values for the most common orthopedic and nonorthopedic procedures between 2000 and 2016. Prices were adjusted for inflation to 2016-dollar values...
March 1, 2018: Orthopedics
Christopher J Kleck, Evalina L Burger
CASE: We report the development of bilateral symptomatic facet joint cysts in a 78-year-old man who had been treated with decompression and placement of a coflex device (Paradigm Spine) at L3-L4 and L4-L5. Preoperative imaging clearly demonstrated fluid in the facet joints without cysts. He underwent standard surgical treatment, but developed symptomatic facet joint cysts at 4 months postoperatively. The patient was treated with a revision decompression and replacement of the devices; there were no issues at the 32-month follow-up...
February 28, 2018: JBJS Case Connector
Wei Yuan, Xuan Liu, Xiaoshu Zhou, Lei Pei, Yue Zhu
STUDY DESIGN: A retrospective study. OBJECTIVE: To compare the clinical outcomes of continues irrigation suction systems (CISS) or vacuum assisted closure system (VACS) in early deep wound infection (DWI) after thoracolumbar instrumentation. SUMMARY OF BACKGROUND DATA: DWI after thoracolumbar instrumentation is challenging and debridement followed by either CISS or VACS has been proven to be effective. So far which one of the system has more advantages over the other remains unclear...
February 23, 2018: Spine
Anouar Khayachi, Carole Gwizdek, Gwénola Poupon, Damien Alcor, Magda Chafai, Frédéric Cassé, Thomas Maurin, Marta Prieto, Alessandra Folci, Fabienne De Graeve, Sara Castagnola, Romain Gautier, Lenka Schorova, Céline Loriol, Marie Pronot, Florence Besse, Frédéric Brau, Emmanuel Deval, Barbara Bardoni, Stéphane Martin
Fragile X syndrome (FXS) is the most frequent inherited cause of intellectual disability and the best-studied monogenic cause of autism. FXS results from the functional absence of the fragile X mental retardation protein (FMRP) leading to abnormal pruning and consequently to synaptic communication defects. Here we show that FMRP is a substrate of the small ubiquitin-like modifier (SUMO) pathway in the brain and identify its active SUMO sites. We unravel the functional consequences of FMRP sumoylation in neurons by combining molecular replacement strategy, biochemical reconstitution assays with advanced live-cell imaging...
February 22, 2018: Nature Communications
Jonathan A Mitchell, Alessandra Chesi, Shana E McCormack, Diana L Cousminer, Heidi J Kalkwarf, Joan M Lappe, Vicente Gilsanz, Sharon E Oberfield, John A Shepherd, Andrea Kelly, Struan F A Grant, Babette S Zemel
PURPOSE: To determine if replacing time spent in high and low impact physical activity (PA) predicts changes in pediatric bone mineral density (BMD) and content (BMC). METHODS: We analyzed data from the longitudinal Bone Mineral Density in Childhood Study (N=2,337 with up to 7 visits). The participants were aged 5-19 years at baseline, 51.2% were female and 80.6% were non-Black. Spine, total hip, and femoral neck areal BMD (aBMD) and total body less head (TBLH) BMC Z-scores were calculated...
February 20, 2018: Medicine and Science in Sports and Exercise
Purnima Agarwal, Ramesh Gomez, Eesh Bhatia, Subhash Yadav
Sheehan's syndrome (SS) is an important cause of pan-hypopituitarism in women. There is scanty information on bone mineral density (BMD) in this condition. We determined BMD and the changes in BMD after oestrogen (E2) replacement and nutritional supplementation in women with SS. In a cross-sectional study, BMD was measured by DEXA in 83 patients [age (mean ± SD) 42 ± 9.2 years] and compared with an equal number of matched controls. In a sub-set of 19 patients, we conducted an open-label, prospective study to determine changes in BMD after 1 year of replacement of E2, and calcium and vitamin D3 supplementation...
February 20, 2018: Journal of Bone and Mineral Metabolism
Wei Yuan, Haiping Zhang, Xiaoshu Zhou, Weidong Wu, Yue Zhu
OBJECTIVE: Artificial cervical disc replacement is expected to maintain normal cervical biomechanics. The effect of Prestige LP prosthesis height on cervical biomechanics has not been thoroughly studied yet. This finite element (FE) study of the cervical biomechanics aims to predict how the parameters like range of motion (ROM), adjacent intradiscal pressure, facet joint force and bone-implant interface stress are affected by different Prestige LP prosthesis heights. METHODS: The FE model of intact cervical spine (C3-C7) was obtained from our previous study, and the model was altered to implant Prestige LP prostheses at the C5-C6 level...
February 17, 2018: World Neurosurgery
Aymeric Faure, Marc Khalifé, Benjamin Thiebaut, François Roubineau, Charles Henri Flouzat Lachaniette, Arnaud Dubory
STUDY DESIGN: Retrospective cohort study OBJECTIVE.: To analyze the clinical and radiographic outcomes of patients undergoing a one-level lumbar total disc replacement (TDR), according to the initial sagittal alignment of the spine. SUMMARY OF BACKGROUND DATA: No authors have highlighted correlation between the initial spino-pelvic parameters and the postoperative outcome after a one-level TDR. METHODS: Seventy-eight patients were included: 14 TDR at L4-L5 and 64 TDR at L5-S1 level...
February 15, 2018: Spine
Anne F Mannion, Franco M Impellizzeri, Michael Leunig, Dezsö Jeszenszy, Hans-Jürgen Becker, Daniel Haschtmann, Stefan Preiss, Tamas F Fekete
PURPOSE: Studies comparing the outcome of spine surgery with that of large-joint replacement report equivocal findings. The patient-reported outcome measures (PROMs) used in such studies are typically generic and may not be sufficiently sensitive to the successes/failures of treatment. This study compared different indices of "success" in patients undergoing surgery for degenerative disorders of the lumbar spine, hip, or knee, using a validated, multidimensional, and joint-specific PROM...
February 19, 2018: European Spine Journal
Steven J McAnany, Robert K Merrill, Samuel C Overley, Jun S Kim, Robert L Brochin, Sheeraz A Qureshi
Study Design: Cost-effectiveness analysis. Objectives: To determine the 7-year cost-effectiveness of cervical disc replacement (CDR) and anterior cervical discectomy and fusion (ACDF). Methods: We analyzed 7-year Short Form-36 Health Survey data collected from the Prestige Cervical Disc investigational device exemption study (IDE). The SF-6D algorithm was used to convert this data into health state utilities. Costs were calculated from the payer perspective, and quality adjusted life years (QALYs) were used to represent effectiveness...
February 2018: Global Spine Journal
Steven J McAnany, Robert K Merrill, Robert L Brochin, Samuel C Overley, Jun S Kim, Sheeraz A Qureshi
Study Design: Health utility analysis. Objectives: To determine the health state utility (HSU) of 1- and 2-level anterior cervical discectomy and fusion (ACDF) and cervical disc replacement (CDR). Methods: Data from the Medtronic Prestige Cervical Disc investigational device exemption studies was used. Four groups were defined: 1-level ACDF, 1-level CDR, 2-level ACDF, and 2-level CDR. The 36-item Short Form Health Survey (SF-36) was collected at baseline, 12 months, 24 months, 36 months, and 60 months postoperatively and converted into utility scores for each time point...
February 2018: Global Spine Journal
Jeffrey Loh-Doyle, Mukul B Patil, Hari Sawkar, Kevin Wayne, Stuart D Boyd
BACKGROUND: After radical cystoprostatectomy (RC), postoperative erectile dysfunction (ED) is a common consequence with multiple contributing etiologies. The inflatable penile prosthesis (IPP) offers patients a definitive treatment option when ED is refractory to medical therapies. Because of the hostile postoperative anatomy of these patients, a careful surgical approach is necessary for successful outcomes and to avoid adjacent organ injury. To date, there is no series describing the outcomes of 3-piece IPP placement in patients with urinary diversions...
February 13, 2018: Journal of Sexual Medicine
Jikai Zhao, Chen Bian, Mengying Liu, Yangang Zhao, Tao Sun, Fangzhou Xing, Jiqiang Zhang
Hippocampal synaptic plasticity is the basis of spatial memory and cognition and is strongly regulated by both testicular androgens (testosterone, T) and hippocampal estrogens (17β-estradiol, E2) converted from T by aromatase, which is inhibited by letrozole (LET), but the contribution of each pathway to spatial memory and the associated mechanisms are unclear. In this study, we first used orchiectomy (ORX) and LET injection to investigate the effects of T and hippocampal E2 on spatial memory and hippocampal synaptic plasticity...
February 13, 2018: Journal of Steroid Biochemistry and Molecular Biology
Hengyan Zhang, Qiyi Li
RATIONALE: Surgical site infection (SSI) following spine surgeries involving internal fixation often require removing the instrument; however, this can cause spinal instability. Previous reports have demonstrated the usefulness of vacuum sealing drainage (VSD) therapy, but the cases require wound opening, aseptic condition to replace the VSD device, and a secondary operation to close the wound. Thus, to improve the VSD treatment and develop a maneuverable procedure, make sense in spine surgery...
February 2018: Medicine (Baltimore)
Sarah E Gullbrand, Dong Hwa Kim, Edward Bonnevie, Beth G Ashinsky, Lachlan J Smith, Dawn M Elliott, Robert L Mauck, Harvey E Smith
Replacement of the intervertebral disc with a viable, tissue-engineered construct that mimics native tissue structure and function is an attractive alternative to fusion or mechanical arthroplasty for the treatment of disc pathology. While a number of engineered discs have been developed, the average size of these constructs remains a fraction of the size of human intervertebral discs. In this study, we fabricated medium (3 mm height x 10 mm diameter) and large (6 mm height x 20 mm diameter) sized disc-like angle ply structures (DAPS), encompassing size scales from the rabbit lumbar spine to the human cervical spine...
February 7, 2018: Acta Biomaterialia
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