Savino Sciascia, D Ware Branch, Roger A Levy, Saskia Middeldorp, Sue Pavord, Dario Roccatello, Guillermo Ruiz-Irastorza, Angela Tincani, Munther Khamashta, Karen Schreiber, Beverley J Hunt
The use of low-dose aspirin and heparinoids has improved the pregnancy outcome in obstetric antiphospholipid syndrome (APS). However, current treatment fails in 20-30% of APS pregnancies, raising the need to explore other treatments to improve obstetrical outcome. Hydroxychloroquine (HCQ) is widely used in patients with autoimmune diseases, mainly systemic lupus erythematous (SLE), due to its anti-inflammatory, anti-aggregant and immune-regulatory properties. Evidence from in vitro and animal models suggests a potential protective effect of HCQ in obstetric APS...
January 2016: Thrombosis and Haemostasis