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pregnancy and systemic lupus erythematous

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https://www.readbyqxmd.com/read/27029214/antiphospholipid-antibody-induced-mir-146a-3p-drives-trophoblast-interleukin-8-secretion-through-activation-of-toll-like-receptor-8
#1
Stefan M Gysler, Melissa J Mulla, Marta Guerra, Jan J Brosens, Jane E Salmon, Lawrence W Chamley, Vikki M Abrahams
STUDY QUESTION: What is the role of microRNAs (miRs) in antiphospholipid antibody (aPL)-induced trophoblast inflammation? SUMMARY ANSWER: aPL-induced up-regulation of trophoblast miR-146a-3p is mediated by Toll-like receptor 4 (TLR4), and miR-146a-3p in turn drives the cells to secrete interleukin (IL)-8 by activating the RNA sensor, TLR8. WHAT IS KNOWN ALREADY: Obstetric antiphospholipid syndrome (APS) is an autoimmune disorder characterized by circulating aPL and an increased risk of pregnancy complications...
July 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/26421409/the-efficacy-of-hydroxychloroquine-in-altering-pregnancy-outcome-in-women-with-antiphospholipid-antibodies-evidence-and-clinical-judgment
#2
Savino Sciascia, D Ware Branch, Roger A Levy, Saskia Middeldorp, Sue Pavord, Dario Roccatello, Guillermo Ruiz-Irastorza, Angela Tincani, Munther Khamashta, Karen Schreiber, Beverley J Hunt
The use of low-dose aspirin and heparinoids has improved the pregnancy outcome in obstetric antiphospholipid syndrome (APS). However, current treatment fails in 20-30% of APS pregnancies, raising the need to explore other treatments to improve obstetrical outcome. Hydroxychloroquine (HCQ) is widely used in patients with autoimmune diseases, mainly systemic lupus erythematous (SLE), due to its anti-inflammatory, anti-aggregant and immune-regulatory properties. Evidence from in vitro and animal models suggests a potential protective effect of HCQ in obstetric APS...
January 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/26105465/pp144-profile-of-lupus-pregnancy-in-internal-medecine-practice
#3
T Haddad, D Hakem, A Berrah
INTRODUCTION: The pregnancies in systemic erythematous lupus (SLE) disease is a situation of high risk and involve both the mother and the fetus. The prematurity and the miscarriage are there more frequent, with increase risks of eclampsia, acute hypertension, HELP syndrome and of worsening renal disease. So the morbimortality is multiplied particularly when a anti-phospholipid syndrome 'APLS' is associated. The pregnancy remains however authorized when the SLE is in remission for more than 6 months with a validated treatment and successful means of monitoring...
July 2012: Pregnancy Hypertension
https://www.readbyqxmd.com/read/25879992/differentiation-between-severe-hellp-syndrome-and-thrombotic-microangiopathy-thrombotic-thrombocytopenic-purpura-and-other-imitators
#4
REVIEW
O Pourrat, R Coudroy, F Pierre
Pre-eclampsia complicated by severe HELLP (hemolysis, elevated liver enzymes and low platelet count) syndrome is a multi-organ disease, and can be difficult to differentiate from thrombotic microangiopathy (appearing as thrombotic thrombocytopenic purpura or hemolytic uremic syndrome), acute fatty liver, systemic erythematous lupus, antiphospholipid syndrome and severe sepsis. Many papers have highlighted the risks of misdiagnosis resulting in severe consequences for maternal health, and this can be fatal when thrombotic thrombocytopenic purpura is misdiagnosed as severe HELLP syndrome...
June 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/25391176/neonatal-lupus-erythematosus-a-20-year-retrospective-study
#5
Srisupalak Singalavanija, Wanida Limpongsanurak, Sutticha Aoongern
OBJECTIVE: To study clinical manifestations, investigations, treatment and outcomes of neonatal lupus erythematosus (NLE) patients and their mothers. MATERIAL AND METHOD: A retrospective descriptive study was performed to review the neonatal lupus erythematosus patients and their mothers at Queen Sirikit National Institute of Child Health during January 1993 to December 2013. The diagnostic criteria required the presence of clinical symptoms plus positive anti-Ro/SSA or anti-La/SSB or both...
June 2014: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/24450316/a-6-week-old-boy-with-annular-skin-lesions-neonatal-lupus-erythematosus
#6
Trinidad Hasbún, Sarah L Chamlin
A 6-week-old, otherwise healthy boy presented to the dermatology clinic for evaluation of an eruption involving his scalp, face, and trunk. The truncal lesions had been present for several weeks, and the facial and scalp lesions were noticed 5 days prior to presentation. The eruption was asymptomatic without scratching or discomfort noted by his mother. Past medical history was remarkable for preterm delivery due to maternal hypertension during pregnancy. The infant was thriving and gaining weight appropriately...
January 1, 2014: Pediatric Annals
https://www.readbyqxmd.com/read/22833437/the-prevalence-of-oral-mucosal-lesions-and-related-factors-in-188-patients-with-systemic-lupus-erythematosus
#7
M Khatibi, A H Shakoorpour, Z Moosavian Jahromi, A Ahmadzadeh
BACKGROUND: One of the most important concerns about systemic lupus erythematosus (SLE) is the presence of oral lesions, which in turn is one of the diagnostic criteria for SLE. Regarding the wide range of oral lesions and the absence of comprehensive data in Iran, this study aimed to evaluate the prevalence of oral mucosal lesions and related factors in patients with SLE at three rheumatology clinics in Tehran. METHODS: This descriptive study was performed on 188 patients by observation, clinical examination, completing questionnaire and also evaluating patients' medical records...
October 2012: Lupus
https://www.readbyqxmd.com/read/22495199/-a-case-of-neonatal-lupus-syndrome-and-congenital-atrioventricular-block-associated-with-maternal-antibodies-antiro-ss-a
#8
C De Leonibus, C Lembo, P Giliberti, S Rojo, M C Foglia, L Giordano, A Fratta
The neonatal lupus erythematosus syndrome (LEN) is a disease due to the transplacental passage of maternal antiextractable nuclear antigens (ENA) antibodies, particularly anti-Ro/SS-A and anti-La/SS-B. The disease affects neonates born from mothers with autoimmune diseases. It is characterized by erythematous annular polycylic skin lesions, slightly scaling with prevalent face localization, hematologic and liver diseases and only in 2% of cases with extracutaneous lesions including complete atrioventricular block...
April 2012: Minerva Pediatrica
https://www.readbyqxmd.com/read/21966795/-uterine-artery-score-in-patients-with-systemic-lupus-erythematous-as-a-predictor-of-intrauterine-growth-restriction
#9
José Angel López-Farfán, Dolores G Martínez-Marín, Tatiana Van Der Heyden-Pardo
BACKGROUND: Because of its high prevalence in the female population and its high incidence in reproductive age, Systemic Lupus Erythematosus can complicate pregnancy causing miscarriage, fetal death, preeclampsia, fetal growth restriction (up to 25%) and preterm birth. Doppler ultrasonography measures the flow in the uterine arteries, which is reduced in patients with preeclampsia and FGR, and thus is an ideal method for identifying pregnant women with a high risk of developing an adverse perinatal outcome...
March 2011: Ginecología y Obstetricia de México
https://www.readbyqxmd.com/read/20225778/etiological-patterns-of-stroke-in-young-patients-at-a-tertiary-care-hospital
#10
Shaikh Samiullah, Mona Humaira, Ghani Hanif, Aslam Aziz Ghouri, Khalid Shaikh
OBJECTIVE: To observe frequency of various causes of stroke in patients of young (15-35 years) age. METHODS: This Descriptive case series study was conducted in all Medical Units of Liaquat University Hospital (LUH) Jamshoro, Hyderabad, from August 2006 to February 2008 and included 50 patients of stroke aged 15-35 years, irrespective of sex and community. Data of these patients was collected through a pre-designed proforma by completing a comprehensive history, detailed examination and carrying out basic and relevant investigations...
March 2010: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/20143981/endometriosis-associated-lyme-disease
#11
I M Matalliotakis, H Cakmak, M D E Ziogos, A Kalogeraki, D Kappou, A Arici
The aim of this study is to report three cases of patients with endometriosis and infertility, and associated with Lyme disease. The medical files of 405 women with endometriosis and 200 without endometriosis were studied retrospectively. We report 3 cases with endometriosis and Lyme disease. Of 405 patients with endometriosis treated in our study over a 6-year period, 3(0.8%) had Lyme disease. All cases presented with typical erythema migraines, fever and fatigue. The serological findings were positive for Borrelia burgdorferi, for 3 cases...
February 2010: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/17971365/neonatal-lupus-erythematosus-complicated-by-mucocutaneous-and-visceral-hemangiomas
#12
S J Spalding, T Hennon, J Dohar, T Arkachaisri
Neonatal lupus erythematosus (NLE) is a passively acquired autoimmune syndrome resulting from transplacental passage of maternal anti-Ro/SSA and/or anti-La/SSB antibodies to the fetus. Characteristic manifestations of NLE include transient dermatitis, hepatic and hematologic abnormalities and congenital heart block. Skin lesions in NLE resemble subacute cutaneous lupus erythematosus and typically consist of annular, erythematous, scaly plaques. Telangiectasias, vascular abnormalities resulting from dilation of superficial dermal vessels, may also affect the skin in a minority of patients...
2007: Lupus
https://www.readbyqxmd.com/read/17389196/fetal-congenital-lobar-emphysema
#13
Chun-Chieh Chia, Soon-Cen Huang, Min-Chang Liu, Tung-Yi Se
OBJECTIVE: To report a rare fetal congenital lung anomaly characterized by over inflation of a pulmonary lobe. CASE REPORT: A 28-year-old systemic lupus erythematous mother, gravida 1 para 0, who had normal prenatal care in our department, was admitted for labor pain and an abnormal fetal heart location was noted incidentally during labor. The baby showed rib retraction in room air but no obvious cyanotic change after delivery. Both the fetus chest X-ray and ultrasound showed a hyperechogenic tumor in the left thoracic cavity with a right-side-shifted heart and trachea...
March 2007: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/16008653/lichen-striatus-in-a-pregnant-woman
#14
Sarah Brennand, Sant Khan, Alvin H Chong
We report a case of lichen striatus in a 37-year-old woman in the third trimester of pregnancy. She presented at 35 weeks of pregnancy with a 6-week history of a pruritic rash on the left side of her abdomen. Examination revealed an erythematous papular eruption arranged in a linear fashion from the umbilicus to the left mid back. Histological examination demonstrated lichenoid perivascular and periadnexal inflammatory infiltrate and the presence of colloid bodies. The eruption resolved prior to delivery with the application of mometasone furoate 0...
August 2005: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/14619694/-systemic-lupus-erythematous-and-pregnancy
#15
Radamés Rivas-López, Rafael Buitrón García-Figueroa, Raúl Romero-Cabello
OBJECTIVE: To determine the obstetrics outcomes of patients with systemic lupus erythematosus and pregnancy. MATERIALS AND METHODS: A retrospective, analytic, and descriptive case of study is presented about of the obstetrics outcomes of patients with systemic lupus erythematosus and pregnancy attended in Hospital General de Mexico Obstetrics and Gynecology Service from June, 2000 to February, 2003. RESULTS: Thirty-six records were reviewed...
August 2003: Ginecología y Obstetricia de México
https://www.readbyqxmd.com/read/12378974/-neonatal-cutaneous-lupus-necessary-interdisciplinary-collaboration
#16
J Stirnemann, O Fain, E Lachassinne, R Levet, L Carbillon, A Kettaneh, M H Aurousseau, M Uzan, M Thomas
INTRODUCTION: Neonatal lupus erythematosus is a rare syndrome (affecting 5% of the children born of mothers with lupus), characterized essentially by cutaneous lesions and/or congenital auricular-ventricular heart block. It is due to the transplacental passage of maternal antibodies (anti-SSA or anti-SSB, or occasionally anti-U1RNP antibodies) into the fetal circulation. OBSERVATION: We report a case of neonatal lupus erythematosus, having appeared 4 weeks after birth...
September 21, 2002: La Presse Médicale
https://www.readbyqxmd.com/read/11315350/update-on-therapy-thalidomide-in-the-treatment-of-lupus
#17
REVIEW
M Y Karim, G Ruiz-Irastorza, M A Khamashta, G R Hughes
Thalidomide has been shown to be an effective treatment for cutaneous forms of lupus erythematous refractory to other therapies. Thalidomide has very serious side effects, including teratogenicity and neuropathy, which limit its clinical use in lupus to such severe refractory cases. Efficacy has been confirmed in several studies, although recurrence after discontinuation of treatment is frequent. More recent experience suggests that lower doses than originally used may be effective, which may result in a reduction in side effects...
2001: Lupus
https://www.readbyqxmd.com/read/11060383/-cutaneous-neonatal-lupus-erythematosus-discordant-expression-in-identical-twins
#18
M L Batard, D Sainte-Marie, E Clity, S Belhabri, P Cotellon, R Pradinaud
BACKGROUND: Neonatal lupus erythematosus is a rare syndrome characterized essentially by cutaneous lesions and/or congenital heart block occurring in infants at birth, or shortly after. It is related to transplacental crossing of maternal auto antibodies (usually anti Ro/SS-A, La/SS-B or rarely anti-U(1) RNP) from the mother to the infant. Mothers of affected children have signs of systemic lupus erythematosus or other collagenosis or are asymptomatic. CASE REPORT: We report a case of neonatal lupus erythematosus in one identical twin, revealed at the age of 3 months by erythematous and annular cutaneous lesions of the face and limbs...
October 2000: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/9759570/-neonatal-lupus-erythematosus-and-maternal-hellp-syndrome-is-there-a-pathogenetic-link
#19
P Freyschmidt-Paul, C H Rieger, R Happle, R Hoffmann
A newborn boy developed annular erythematous lesions on his entire body. Histopathological examination showed typical features of lupus erythematosus. His mother was positive for anti-Ro/SSa and anti-La/SSb antibodies. Neonatal lupus erythematosus was diagnosed. During pregnancy the mother had suffered from HELLP syndrome. The reported case points out the necessity to differentiate HELLP syndrome from first manifestation of lupus erythematosus during pregnancy. A direct causal relationship between neonatal lupus erythematosus and HELLP syndrome of the mother seems to be unlikely...
August 1998: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/9003342/central-serous-chorioretinopathy-in-patients-with-systemic-lupus-erythematosus
#20
REVIEW
E T Cunningham, P R Alfred, A R Irvine
PURPOSE: To describe three patients with systemic lupus erythematosus in whom ophthalmoscopic and fluorescein angiographic evidence of central serous chorioretinopathy developed. METHODS: The authors retrospectively reviewed the clinical and photographic records of three patients with systemic lupus erythematous in whom central serous chorioretinopathy developed. RESULTS: Ophthalmoscopic changes observed in these patients with systemic lupus erythematosus included discrete areas of clumping and mottling of the retinal pigment epithelium (RPE), focal RPE detachments, serous elevations of the neurosensory retina, and late subretinal fibrosis with scar formation...
December 1996: Ophthalmology
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