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FoxM1 AND LDH

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https://www.readbyqxmd.com/read/26261559/foxm1-ldha-signaling-promoted-gastric-cancer-glycolytic-phenotype-and-progression
#1
Weihua Jiang, Fei Zhou, Ning Li, Qi Li, Liwei Wang
The oncogenic transcription factor forkhead box protein M1 (FOXM1) plays critical roles in gastric cancer (GC) development and progression. However, the underlying mechanisms has not fully demonstrated. Lactate dehydrogenase A (LDHA) is widely overexpressed in a series of cancers and is one of the two subunits of Lactate dehydrogenase (LDH), which is the key glycolytic enzyme and catalyzes the interconversion of pyruvate and lactate. In this study, we characterized the regulation of aerobic glycolysis by FOXM1 via transactivation of LDHA in GC...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/24634381/foxm1-promotes-the-warburg-effect-and-pancreatic-cancer-progression-via-transactivation-of-ldha-expression
#2
Jiujie Cui, Min Shi, Dacheng Xie, Daoyan Wei, Zhiliang Jia, Shaojiang Zheng, Yong Gao, Suyun Huang, Keping Xie
PURPOSE: The transcription factor Forkhead box protein M1 (FOXM1) plays critical roles in cancer development and progression. However, the regulatory role and underlying mechanisms of FOXM1 in cancer metabolism are unknown. In this study, we characterized the regulation of aerobic glycolysis by FOXM1 and its impact on pancreatic cancer metabolism. EXPERIMENTAL DESIGN: The effect of altered expression of FOXM1 on expression of glycolytic enzymes and tumor development and progression was examined using animal models of pancreatic cancer...
May 15, 2014: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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