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Lactate AND Homeostasis

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https://www.readbyqxmd.com/read/29781141/resveratrol-relieves-particulate-matter-mean-diameter-2-5-%C3%AE-m-induced-oxidative-injury-of-lung-cells-through-attenuation-of-autophagy-deregulation
#1
Yuan Li, Weiwei Qian, Dengdian Wang, Yu Meng, Xiaoqian Wang, Yue Chen, Xiaoting Li, Chunfeng Xie, Caiyun Zhong, Suming Fu
Oxidative stress and inflammation are critically implicated in ambient fine particulate matter (mean diameter < 2.5 μm; PM2.5 )-induced lung injury. Autophagy, playing a crucial role in various physiopathological conditions, modulates cellular homeostasis and stress adaptation. Resveratrol is a phytoalexin that exerts potent antioxidant effects on cardiopulmonary diseases. To date, the mechanisms by which resveratrol protects against PM2.5 remain to be elucidated. In the present study, we investigated the effect of resveratrol on PM2...
May 20, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29772253/interstitial-ion-homeostasis-and-acid-base-balance-are-maintained-in-oedematous-brain-of-mice-with-acute-toxic-liver-failure
#2
Marta Obara-Michlewska, Fengfei Ding, Mariusz Popek, Alexei Verkhratsky, Maiken Nedergaard, Magdalena Zielinska, Jan Albrecht
Acute toxic liver failure (ATLF) rapidly leads to brain oedema and neurological decline. We evaluated the ability of ATLF-affected brain to control the ionic composition and acid-base balance of the interstitial fluid. ATLF was induced in 10-12 weeks old male C57Bl mice by single intraperitoneal (i.p.) injection of 100 μg/g azoxymethane (AOM). Analyses were carried out in cerebral cortex of precomatous mice 20-24 h after AOM administration. Brain fluid status was evaluated by measuring apparent diffusion coefficient [ADC] using NMR spectroscopy, Evans Blue extravasation, and accumulation of an intracisternally-injected fluorescent tracer...
May 14, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29760743/crosstalk-between-the-warburg-effect-redox-regulation-and-autophagy-induction-in-tumourigenesis
#3
REVIEW
Mokgadi Violet Gwangwa, Anna Margaretha Joubert, Michelle Helen Visagie
Tumourigenic tissue uses modified metabolic signalling pathways in order to support hyperproliferation and survival. Cancer-associated aerobic glycolysis resulting in lactic acid production was described nearly 100 years ago. Furthermore, increased reactive oxygen species (ROS) and lactate quantities increase metabolic, survival and proliferation signalling, resulting in increased tumourigenesis. In order to maintain redox balance, the cell possesses innate antioxidant defence systems such as superoxide dismutase, catalase and glutathione...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29759594/liquid-chromatography-mass-spectrometry-based-metabolomics-and-lipidomics-reveal-toxicological-mechanisms-of-bisphenol-f-in-breast-cancer-xenografts
#4
Chao Zhao, Peisi Xie, Hailin Wang, Zongwei Cai
Bisphenol F (BPF) is a major alternative to bisphenol (BPA) and has been widely used. Although BPA exposure is known to generate various toxic effects, toxicity of BPF remains under-explored. A comprehensive method involving mass spectrometry (MS)-based global lipidomics and metabolomics, and matrix-assisted laser desorption/ionization-mass spectrometry (MALDI)- MS imaging (MSI) was used to study toxic effects of BPF and the underlying mechanisms on tumor metastasis-related tissues (liver and kidney) in breast cancer xenografts...
May 5, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29758129/twenty-four-hour-normothermic-perfusion-of-discarded-human-kidneys-with-urine-recirculation
#5
Annemarie Weissenbacher, Letizia Lo Faro, Olga Boubriak, Maria F Soares, Ian S Roberts, James P Hunter, Daniel Voyce, Nikolay Mikov, Andrew Cook, Rutger J Ploeg, Constantin C Coussios, Peter J Friend
Transportable normothermic kidney perfusion for 24 hours or longer could enable viability assessment of marginal grafts, increased organ utilization and improved transplantation logistics. Eleven clinically-declined kidneys were perfused normothermically, six from donors after brain stem death (DBD, median cold ischemia time 33±36.9 hours) and five from donors after circulatory death (DCD, 36.2±38.3 hours): n=3 kidneys were perfused using Ringer's lactate to replace excreted urine volume, and n=8 using urine recirculation to maintain perfusate volume without fluid replenishment...
May 14, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29752297/lactational-programming-of-glucose-homeostasis-a-window-of-opportunity
#6
Lindsay Ellsworth, Emma Harman, Vasantha Padmanabhan, Brigid Gregg
The window of lactation is a critical period during which nutritional and environmental exposures impact lifelong metabolic disease risk. Significant organ and tissue development, organ expansion, and maturation of cellular functions occur during the lactation period, making this a vulnerable time during which transient insults can have lasting effects. This review will cover current literature on factors influencing lactational programming such as milk composition, maternal health status, and environmental endocrine disruptors...
May 11, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29751795/inhibition-of-glutamate-oxaloacetate-transaminase-1-in-cancer-cell-lines-results-in-altered-metabolism-with-increased-dependency-of-glucose
#7
Xiaoshan Zhou, Sophie Curbo, Fuqiang Li, Shuba Krishnan, Anna Karlsson
BACKGROUND: Glutamate oxaloacetate transaminase 1 (GOT1) regulates cellular metabolism through coordinating the utilization of carbohydrates and amino acids to meet nutrient requirements. KRAS mutated cancer cells were recently shown to rely on GOT1 to support long-term cell proliferation. The aim of the present study was to address the role of GOT1 in the metabolic adaption of cancer cells. METHODS: GOT1-null and knockdown cell lines were established through CRISPR/Cas9 and shRNA techniques...
May 11, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29738792/energy-homeostasis-and-running-wheel-activity-during-pregnancy-in-the-mouse
#8
S R Ladyman, K M Carter, D R Grattan
Pregnancy and lactation are metabolically challenging states, where the mother must supply all the energy requirements for the developing fetus and growing pups respectively. The aim of the current study was to characterize many aspects of energy homeostasis before and during pregnancy in the mouse, and to examine the role of voluntary activity on changes in energy expenditure during pregnancy. In a secondary aim, we evaluate measures of energy homeostasis during pregnancy in mice that successfully reared their litter or in mice that went on to abandon their litter, to determine if an impairment in pregnancy-induced adaptation of energy homeostasis might underlie the abandonment of pups soon after birth...
May 5, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29730509/protein-restriction-diet-during-the-suckling-phase-programs-rat-metabolism-against-obesity-and-insulin-resistance-exacerbation-induced-by-a-high-fat-diet-in-adulthood
#9
Isabela Peixoto Martins, Júlio Cezar de Oliveira, Audrei Pavanello, Camila Cristina Ianoni Matiusso, Carina Previate, Laize Peron Tófolo, Tatiane Aparecida Ribeiro, Claudinéia Conationi da Silva Franco, Rosiane Aparecida Miranda, Kelly Valério Prates, Vander Silva Alves, Flávio Andrade Francisco, Ana Maria Praxedes de Moraes, Paulo Cezar de Freitas Mathias, Ananda Malta
Protein restriction during the suckling phase can malprogram rat offspring to a lean phenotype associated with metabolic dysfunctions later in life. We tested whether protein-caloric restriction during lactation can exacerbate the effect of a high-fat (HF) diet at adulthood. To test this hypothesis, we fed lactating Wistar dams with a low-protein (LP; 4% protein) diet during the first 2 weeks of lactation or a normal-protein (NP; 23% protein) diet throughout lactation. Rat offspring from NP and LP mothers received a normal-protein diet until 60 days old...
April 3, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29710464/cistanche-deserticola-polysaccharides-protects-pc12-cells-against-ogd-rp-induced-injury
#10
Yue Liu, Hui Wang, Mei Yang, Ning Liu, Yuping Zhao, Xue Qi, Yang Niu, Tao Sun, Yuxiang Li, Jianqiang Yu
Ischemia stroke is a disease with high morbidity and mortality. Cistanche deserticola polysaccharides (CDP) possess a wide range of beneficial effects, including hepatoprotection and immune homeostasis. As far as we know, the protective effect of CDP on neurons injured by oxygen-glucose deprivation/reperfusion (OGD/RP) has not been investigated. In this study, OGD/RP injured a PC12 cell model. Briefly, CDP (0.05, 0.5 and 5??g/ml) was administered before reperfusion. The protective effect of CDP was then evaluated on the basis of cell viability, lactate dehydrogenase (LDH) leakage, [Ca2+ ]i , mitochondrial membrane potential (MMP)and cell apoptosis, and redox status after reperfusion was evaluated by assaying reactive oxygen species (ROS), catalase (CAT), glutathione peroxidase (GSH-Px) and total antioxidant capacity...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29705428/adsa-foundation-scholar-award-a-role-for-serotonin-in-lactation-physiology-where-do-we-go-from-here
#11
L L Hernandez
Lactation is a physiological event that is exclusive to mammals. Lactation evolved as a strategy to improve the survival of the young by providing them with the complete nutrition that is required for survival upon birth as well as maternal-offspring bonding. Typically, milk production by the dam matches the demand of the young. The dairy cow is a unique exception in which the discoveries and genetic selection related to lactation physiology have been applied and resulted in a dramatic increase in milk yield of dairy cows...
April 25, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29680643/phosphorylation-of-nuclear-factor-erythroid-2-like-2-nfe2l2-in-mammary-tissue-of-holstein-cows-during-the-periparturient-period-is-associated-with-mrna-abundance-of-antioxidant-gene-networks
#12
L Q Han, Z Zhou, Y Ma, F Batistel, J S Osorio, J J Loor
Changes in the production of reactive oxygen species in the mammary gland of dairy cows during the periparturient period could lead to oxidative stress and potentially impair mammary function. Phosphorylation of the transcription factor nuclear factor erythroid 2-like 2 (NFE2L2), also known as nuclear factor-E2-related factor 2, controls mRNA abundance of genes encoding antioxidant proteins and enzymes. The hypothesis was that NFE2L2 phosphorylation status and target gene mRNA abundance in the mammary gland of dairy cows is altered around parturition...
April 18, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29668681/a-longitudinal-1h-nmr-metabolomics-analysis-of-urine-from-newborns-with-hypoxic-ischemic-encephalopathy-undergoing-hypothermia-therapy-clinical-and-medical-legal-insights
#13
Emanuela Locci, Antonio Noto, Melania Puddu, Giulia Pomero, Roberto Demontis, Cristina Dalmazzo, Antonio Delogu, Vassilios Fanos, Ernesto d'Aloja, Paolo Gancia
Perinatal asphyxia is an event affecting around four million newborns worldwide. The 0.5 to 2 per 1000 of full term asphyxiated newborns suffer from hypoxic-ischemic encephalopathy (HIE), which is a frequent cause of death or severe disability and, as consequence, the most common birth injury claim for obstetrics, gynaecologists, and paediatricians. Perinatal asphyxia results from a compromised gas exchange that leads to hypoxemia, hypercapnia, and metabolic acidosis. In this work, we applied a metabolomics approach to investigate the metabolic profiles of urine samples collected from full term asphyxiated newborns with HIE undergoing therapeutic hypothermia (TH), with the aim of identifying a pattern of metabolites associated with HIE and to follow their modifications over time...
2018: PloS One
https://www.readbyqxmd.com/read/29659786/impact-of-pregnancy-and-lactation-on-the-long-term-regulation-of-energy-balance-in-female-mice
#14
Sharon Rachel Ladyman, Zin Khant Aung, David Ross Grattan
During pregnancy and lactation, the maternal body undergoes many changes in the regulation of appetite, body weight and glucose homeostasis to deal with the metabolic demands of the growing fetus and subsequent demands of providing milk for offspring. The aim of the current study was to investigate the consequences of one reproductive cycle of pregnancy and lactation on the long-term regulation of energy homeostasis. After weaning of pups, reproductively experienced (RE) mice maintained a higher body weight compared to age-matched control mice...
April 11, 2018: Endocrinology
https://www.readbyqxmd.com/read/29625242/soya-saponins-induce-intestinal-inflammation-and-barrier-dysfunction-in-juvenile-turbot-scophthalmus-maximus
#15
Min Gu, Qian Jia, Zhiyu Zhang, Nan Bai, Xiaojie Xu, Bingying Xu
Soybean meal-induced enteritis (SBMIE) is a well-described condition in the distal intestine (DI) of several cultured fish species, but the exact cause is still unclear. The work on Atlantic salmon and zebrafish suggested soya-saponins, as heat-stable anti-nutritional factors in soybean meal, are the major causal agents. However, this conclusion was not supported by the research on some other fish, such as gilthead sea bream and European sea bass. Our previous work proved that soybean could induce SBMIE on turbot and the present work aimed to investigate whether soya-saponins alone could cause SBMIE and the effects of soya-saponins on the intestinal barrier function in juvenile turbot...
April 3, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29618761/qil1-dependent-assembly-of-micos-complex-lethal-mutation-in-c19orf70-resulting-in-liver-disease-and-severe-neurological-retardation
#16
J Gödiker, M Grüneberg, I DuChesne, J Reunert, S Rust, C Westermann, Y Wada, G Classen, C D Langhans, K P Schlingmann, R J Rodenburg, R Pohlmann, T Marquardt
Seven subunits of the mitochondrial contact site and cristae junction (CJ) organizing system (MICOS) in humans have been recently described in function and structure. QIL1 (also named MIC13) is a small complex that is crucial for the maintenance and assembling of MICOS. A novel mutation of an essential splice site in the C19orf70 gene encoding QIL1 induces severe mitochondrial encephalopathy, hepatopathy and lactate acidosis consistent with psychomotor retardation. In addition, bilateral kidney stones were observed...
April 4, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29617370/metabolic-and-hormonal-adaptation-in-bubalus-bubalis-around-calving-and-early-lactation
#17
Enrico Fiore, Francesca Arfuso, Matteo Gianesella, Domenico Vecchio, Massimo Morgante, Elisa Mazzotta, Tamara Badon, Pasquale Rossi, Silvia Bedin, Giuseppe Piccione
Pregnancy and lactation are physiological periods that result in an increased metabolic demand that, if not satisfied, could provoke a threat to homeostasis. In this study changes in the values of Non-Esterified Fatty Acids (NEFA) and β-hydroxybutyrate (BHB), glucose, insulin, thyroid hormones, milk composition and yield were investigated in buffaloes during the late pregnancy and early lactation. From a total of 50 buffaloes, blood samples were collected -7±5 days before expected calving; +7±5; +30±5 and +50±5 days post-partum; milk samples were collected at the same post-partum time points...
2018: PloS One
https://www.readbyqxmd.com/read/29603039/could-use-of-selective-serotonin-reuptake-inhibitors-during-lactation-cause-persistent-effects-on-maternal-bone
#18
REVIEW
Samantha R Weaver, Laura L Hernandez
The lactating mammary gland elegantly coordinates maternal homeostasis to provide calcium for milk. During lactation, the monoamine serotonin regulates the synthesis and release of various mammary gland-derived factors, such as parathyroid hormone-related protein (PTHrP), to stimulate bone resorption. Recent evidence suggests that bone mineral lost during prolonged lactation is not fully recovered following weaning, possibly putting women at increased risk of fracture or osteoporosis. Selective Serotonin Reuptake Inhibitor (SSRI) antidepressants have also been associated with reduced bone mineral density and increased fracture risk...
March 30, 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29594386/mutational-analysis-uncovers-monogenic-bone-disorders-in-women-with-pregnancy-associated-osteoporosis-three-novel-mutations-in-lrp5-col1a1-and-col1a2
#19
S Butscheidt, A Delsmann, T Rolvien, F Barvencik, M Al-Bughaili, S Mundlos, T Schinke, M Amling, U Kornak, R Oheim
Pregnancy was found to be a skeletal risk factor promoting the initial onset of previously unrecognized monogenic bone disorders, thus explaining a proportion of cases with pregnancy-associated osteoporosis. Therapeutic measures should focus in particular on the normalization of the disturbed calcium homeostasis in order to enable the partial skeletal recovery. INTRODUCTION: Pregnancy-associated osteoporosis (PAO) is a rare skeletal condition, which is characterized by a reduction in bone mineral density (BMD) in the course of pregnancy and lactation...
March 29, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29588166/the-iron-pro-chelator-bhapi-attenuates-glutamate-induced-oxidative-stress-via-wnt-%C3%AE-catenin-pathway-in-ht22-cells
#20
Fei Gao, Bao Wang, Tao Chang, Min Li, Wei Fang, Zhi-Hong Li, Li Gao
Disturbances in intracellular iron homeostasis are associated with brain damage under various neuropathological conditions. However, exposure of neuronal cells to classical iron chelators could interfere with physiological iron functions in the brain. Thus, iron pro-chelators represent a more advanced approach to exert strong free-iron binding capacity only under oxidative stress conditions. In the present study, we investigated the protective effects of an iron pro-chelator BHAPI [(E)-N'-(1-(2-((4- (4,4,5,5-tetramethyl-1,2,3-dioxoborolan-2-yl)benzyl)oxy)phenyl)ethylidene) isonicotino hydrazide] against glutamate-induced toxicity in neuronal HT22 cells...
March 26, 2018: Brain Research Bulletin
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