keyword
MENU ▼
Read by QxMD icon Read
search

Lactate AND Homeostasis

keyword
https://www.readbyqxmd.com/read/29154687/pyruvate-enhancement-of-cardiac-performance-cellular-mechanisms-and-clinical-application
#1
Robert T Mallet, Albert H Olivencia-Yurvati, Rolf Bünger
Cardiac contractile function is adenosine-5'-triphosphate (ATP)-intensive, and the myocardium's high demand for oxygen and energy substrates leaves it acutely vulnerable to interruptions in its blood supply. The myriad cardioprotective properties of the natural intermediary metabolite pyruvate make it a potentially powerful intervention against the complex injury cascade ignited by myocardial ischemia-reperfusion. A readily oxidized metabolic substrate, pyruvate augments myocardial free energy of ATP hydrolysis to a greater extent than the physiological fuels glucose, lactate and fatty acids, particularly when it is provided at supra-physiological plasma concentrations...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29153989/psen1-mutant-ipsc-derived-model-reveals-severe-astrocyte-pathology-in-alzheimer-s-disease
#2
Minna Oksanen, Andrew J Petersen, Nikolay Naumenko, Katja Puttonen, Šárka Lehtonen, Max Gubert Olivé, Anastasia Shakirzyanova, Stina Leskelä, Timo Sarajärvi, Matti Viitanen, Juha O Rinne, Mikko Hiltunen, Annakaisa Haapasalo, Rashid Giniatullin, Pasi Tavi, Su-Chun Zhang, Katja M Kanninen, Riikka H Hämäläinen, Jari Koistinaho
Alzheimer's disease (AD) is a common neurodegenerative disorder and the leading cause of cognitive impairment. Due to insufficient understanding of the disease mechanisms, there are no efficient therapies for AD. Most studies have focused on neuronal cells, but astrocytes have also been suggested to contribute to AD pathology. We describe here the generation of functional astrocytes from induced pluripotent stem cells (iPSCs) derived from AD patients with PSEN1 ΔE9 mutation, as well as healthy and gene-corrected isogenic controls...
November 12, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29136400/changes-in-bone-turnover-and-calcium-homeostasis-during-pregnancy-and-lactation-in-mammals-a-meta-analysis
#3
Diego A Torres, Mariella B Freitas, Reggiani V Gonçalves
Large amounts of calcium are required during pregnancy and lactation to support fetal and neonatal bone growth and calcification. An inadequate supply of calcium during these stages can lead to unsuccessful reproduction or impaired offspring fitness. During reproduction, female mammals undergo numerous physiological changes, including adaptations to allow an adequate supply of calcium. The lack of quantitative studies analysing these physiological changes from a comparative perspective limits our ability to explain and understand these adaptations...
November 15, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29133512/exosomes-from-adipose-derived-stem-cells-attenuate-adipose-inflammation-and-obesity-through-polarizing-m2-macrophages-and-beiging-in-white-adipose-tissues
#4
Hui Zhao, Qianwen Shang, Zhenzhen Pan, Yang Bai, Zequn Li, Huiying Zhang, Qiu Zhang, Chun Guo, Lining Zhang, Qun Wang
Adipose-derived stem cells (ADSCs) play critical roles in controlling obesity-associated inflammation and metabolic disorders. Exosomes from ADSCs exert protective effects in several diseases, but their roles in obesity and related pathological conditions remain unclear. Here we showed that treatment of obese mice with ADSC-derived exosomes facilitated their metabolic homeostasis including improved insulin sensitivity (27.8% improvement), reduced obesity and alleviated hepatic steatosis. ADSC-derived exosomes drove M2 macrophage polarization, inflammation reduction and beiging in white adipose tissues (WAT) of diet-induced obese mice...
November 13, 2017: Diabetes
https://www.readbyqxmd.com/read/29121875/effect-of-short-term-diet-restriction-on-gene-expression-in-the-bovine-hypothalamus-using-next-generation-rna-sequencing-technology
#5
Daragh Matthews, Michael G Diskin, David A Kenny, Christopher J Creevey, Kate Keogh, Sinead M Waters
BACKGROUND: Negative energy balance (NEB) is an imbalance between energy intake and energy requirements for lactation and body maintenance affecting high-yielding dairy cows and is of considerable economic importance due to its negative impact on fertility and health in dairy herds. It is anticipated that the cow hypothalamus experiences extensive biochemical changes during the early post partum period in an effort to re-establish metabolic homeostasis. However, there is variation in the tolerance to NEB between individual cows...
November 9, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29120752/the-glycogen-shunt-maintains-glycolytic-homeostasis-and-the-warburg-effect-in-cancer
#6
REVIEW
Robert G Shulman, Douglas L Rothman
Despite many decades of study there is a lack of a quantitative explanation for the Warburg effect in cancer. We propose that the glycogen shunt, a pathway recently shown to be critical for cancer cell survival, may explain the excess lactate generation under aerobic conditions characteristic of the Warburg effect. The proposal is based on research on yeast and mammalian muscle and brain that demonstrates that the glycogen shunt functions to maintain homeostasis of glycolytic intermediates and ATP during large shifts in glucose supply or demand...
November 2017: Trends in Cancer
https://www.readbyqxmd.com/read/29108994/nf%C3%AE%C2%BAb-mediated-elevation-of-kcnj11-promotes-tumor-progression-of-hepatocellular-carcinoma-through-interaction-of-lactate-dehydrogenase-a
#7
Ke Zhang, Ling Mu, Ming-Cui Ding, Rui Xu, Zhao-Jun Ding, Jun Liang
It has been well documented that changes in ion fluxes across cellular membranes is fundamental in maintaining cellular homeostasis. Dysregulation and/or malfunction of ion channels are critical events in the pathogenesis of diverse diseases, including cancers. In this study, we focused on the study of K(+) channels in hepatocellular carcinoma (HCC). By data mining TCGA cohort, the expression of 27 K(+) channels was investigated and KCNJ11 was identified as a key dysregulated K(+) channels in HCC. KCNJ11 was differentially expressed in HCC and predicted a poor prognosis in HCC patients...
November 3, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29093434/supplementation-with-achyrocline-satureioides-inflorescence-extracts-to-pregnant-and-breastfeeding-rats-induces-tissue-specific-changes-in-enzymatic-activity-and-lower-neonatal-survival
#8
Karla Suzana Moresco, Alexandre Kleber Silveira, Carlos Eduardo Schnorr, Fares Zeidán-Chuliá, Rafael Calixto Bortolin, Leonardo da Silva Bittencourt, Moara Mingori, Luana Heimfarth, Thallita Kelly Rabelo, Maurilio da Silva Morrone, Juliana Poglia Carini, Daniel Pens Gelain, Valquiria Linck Bassani, José Cláudio Fonseca Moreira
Achyrocline satureioides (AS, family Asteraceae) is a plant widely used in traditional medicine for stomach, digestive, and gastrointestinal disorders during pregnancy. Studies regarding the indiscriminate use of plant infusions during pregnancy are limited. Recent reports have shown that chronic flavonoid supplementation induces toxicity in vivo and raises the mortality rates of healthy subjects. Therefore, we investigated whether supplementation of pregnant and lactating Wistar rats with two AS inflorescence extracts, consisting of an aqueous (AQ) extract similar to a tea (47 mg·kg(-1)·day) and a hydroethanolic (HA) extract (35 mg·kg(-1)·day(-1)) with a higher flavonoid content, could induce redox-related side effects...
August 29, 2017: Biomedicines
https://www.readbyqxmd.com/read/29093287/stilbene-glucoside-a-putative-sleep-promoting-constituent-from-polygonum-multiflorum-affects-sleep-homeostasis-by-affecting-the-activities-of-lactate-dehydrogenase-and-salivary-alpha-amylase
#9
Qian Wei, Guang Ta, Wenjing He, Wei Wang, Qiucheng Wu
Chinese herbal medicine (CHM) has been used for treating insomnia for centuries. The most used CHM for insomnia was Polygonum multiflorum. However, the molecular mechanism for CHM preventing insomnia is unknown. Stilbene glucoside (THSG), an important active component of P. multiflorum, may play an important role for treating insomnia. To test the hypothesis, Kunming mice were treated with different dosages of THSG. To examine the sleep duration, a computer-controlled sleep-wake detection system was implemented...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29078038/influence-of-supraphysiological-cortisol-manipulation-on-predator-avoidance-behaviours-and-physiological-responses-to-a-predation-threat-in-a-wild-marine-teleost-fish
#10
Michael J Lawrence, Erika J Eliason, Jacob W Brownscombe, Kathleen M Gilmour, John W Mandelman, Lee F G Gutowsky, Steven J Cooke
The stress axis in teleost fish attempts to maintain internal homeostasis in the face of allostatic loading. However, stress axis induction has been associated with a higher predation rate in fish. To date, the physiological and behavioural factors associated with this outcome are poorly understood. The purpose of the present study was to investigate the impact of experimental cortisol elevation on anti-predator behaviour and physiological responses to predator presence. We hypothesized that semi-chronic cortisol elevation would increase susceptibility to predation by increasing stress-induced risk taking behaviours...
October 27, 2017: Integrative Zoology
https://www.readbyqxmd.com/read/29075199/brain-ceramide-metabolism-in-the-control-of-energy-balance
#11
REVIEW
Céline Cruciani-Guglielmacci, Miguel López, Mélanie Campana, Hervé le Stunff
The regulation of energy balance by the central nervous system (CNS) is a key actor of energy homeostasis in mammals, and deregulations of the fine mechanisms of nutrient sensing in the brain could lead to several metabolic diseases such as obesity and type 2 diabetes (T2D). Indeed, while neuronal activity primarily relies on glucose (lactate, pyruvate), the brain expresses at high level enzymes responsible for the transport, utilization and storage of lipids. It has been demonstrated that discrete neuronal networks in the hypothalamus have the ability to detect variation of circulating long chain fatty acids (FA) to regulate food intake and peripheral glucose metabolism...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29064557/comparative-genomics-and-transcriptomics-analysis-guided-metabolic-engineering-of-propionibacterium-acidipropionici-for-improved-propionic-acid-production
#12
Ningzi Guan, Bin Du, Jianghua Li, Hyun-Dong Shin, Rachel R Chen, Guocheng Du, Jian Chen, Long Liu
Acid stress induced by the accumulation of organic acids during the fermentation of propionibacteria is a severe limitation in the microbial production of propionic acid (PA). To enhance the acid resistance of strains, the tolerance mechanisms of cells must first be understood. In this study, comparative genomic and transcriptomic analyses were conducted on wild-type and acid-tolerant Propionibacterium acidipropionici to reveal the microbial response of cells to acid stress during fermentation. Combined with the results of previous proteomic and metabolomic studies, several potential acid-resistance mechanisms of P...
October 24, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29044647/epilepsy-and-astrocyte-energy-metabolism
#13
Detlev Boison, Christian Steinhäuser
Epilepsy is a complex neurological syndrome characterized by neuronal hyperexcitability and sudden, synchronized electrical discharges that can manifest as seizures. It is now increasingly recognized that impaired astrocyte function and energy homeostasis play key roles in the pathogenesis of epilepsy. Excessive neuronal discharges can only happen, if adequate energy sources are made available to neurons. Conversely, energy depletion during seizures is an endogenous mechanism of seizure termination. Astrocytes control neuronal energy homeostasis through neurometabolic coupling...
October 17, 2017: Glia
https://www.readbyqxmd.com/read/29043007/amino-acid-supplements-and-metabolic-health-a-potential-interplay-between-intestinal-microbiota-and-systems-control
#14
REVIEW
Francesco Bifari, Chiara Ruocco, Ilaria Decimo, Guido Fumagalli, Alessandra Valerio, Enzo Nisoli
Dietary supplementation of essential amino acids (EAAs) has been shown to promote healthspan. EAAs regulate, in fact, glucose and lipid metabolism and energy balance, increase mitochondrial biogenesis, and maintain immune homeostasis. Basic science and epidemiological results indicate that dietary macronutrient composition affects healthspan through multiple and integrated mechanisms, and their effects are closely related to the metabolic status to which they act. In particular, EAA supplementation can trigger different and even opposite effects depending on the catabolic and anabolic states of the organisms...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/29032506/differential-effects-of-amp-activated-protein-kinase-in-isolated-rat-atria-subjected-to-simulated-ischemia-reperfusion-depending-on-the-energetic-substrates-available
#15
Romina Hermann, Victoria Evangelina Mestre Cordero, María de Las Mercedes Fernández Pazos, Federico Joaquín Reznik, Débora Elisabet Vélez, Enrique Alberto Savino, María Gabriela Marina Prendes, Alicia Varela
AMP-activated protein kinase (AMPK) is a serine-threonine kinase that functions primarily as a metabolic sensor to coordinate anabolic and catabolic processes in the cell, via phosphorylation of multiple proteins involved in metabolic pathways, aimed to re-establish energy homeostasis at a cell-autonomous level. Myocardial ischemia and reperfusion represents a metabolic stress situation for myocytes. Whether AMPK plays a critical role in the metabolic and functional responses involved in these conditions remains uncertain...
October 14, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29026134/mct1-and-mct4-expression-and-lactate-flux-activity-increase-during-white-and-brown-adipogenesis-and-impact-adipocyte-metabolism
#16
Charlotte Petersen, Mette D Nielsen, Elise S Andersen, Astrid L Basse, Marie S Isidor, Lasse K Markussen, Birgitte M Viuff, Ian H Lambert, Jacob B Hansen, Stine F Pedersen
Adipose tissue takes up glucose and releases lactate, thereby contributing significantly to systemic glucose and lactate homeostasis. This implies the necessity of upregulation of net acid and lactate flux capacity during adipocyte differentiation and function. However, the regulation of lactate- and acid/base transporters in adipocytes is poorly understood. Here, we tested the hypothesis that adipocyte thermogenesis, browning and differentiation are associated with an upregulation of plasma membrane lactate and acid/base transport capacity that in turn is important for adipocyte metabolism...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28993701/parkinson-s-disease-related-dj-1-functions-in-thiol-quality-control-against-aldehyde-attack-in-vitro
#17
Noriyuki Matsuda, Mayumi Kimura, Bruno Barros Queliconi, Waka Kojima, Masaki Mishima, Kenji Takagi, Fumika Koyano, Koji Yamano, Tsunehiro Mizushima, Yutaka Ito, Keiji Tanaka
DJ-1 (also known as PARK7) has been identified as a causal gene for hereditary recessive Parkinson's disease (PD). Consequently, the full elucidation of DJ-1 function will help decipher the molecular mechanisms underlying PD pathogenesis. However, because various, and sometimes inconsistent, roles for DJ-1 have been reported, the molecular function of DJ-1 remains controversial. Recently, a number of papers have suggested that DJ-1 family proteins are involved in aldehyde detoxification. We found that DJ-1 indeed converts methylglyoxal (pyruvaldehyde)-adducted glutathione (GSH) to intact GSH and lactate...
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28986525/non-invasive-assessment-of-hepatic-mitochondrial-metabolism-by-positional-isotopomer-nmr-tracer-analysis-pinta
#18
Rachel J Perry, Liang Peng, Gary W Cline, Gina M Butrico, Yongliang Wang, Xian-Man Zhang, Douglas L Rothman, Kitt Falk Petersen, Gerald I Shulman
Hepatic mitochondria play a central role in the regulation of intermediary metabolism and maintenance of normoglycemia, and there is great interest in assessing rates of hepatic mitochondrial citrate synthase flux (V CS) and pyruvate carboxylase flux (V PC) in vivo. Here, we show that a positional isotopomer NMR tracer analysis (PINTA) method can be used to non-invasively assess rates of V CS and V PC fluxes using a combined NMR/gas chromatography-mass spectrometry analysis of plasma following infusion of [3-(13)C]lactate and glucose tracer...
October 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28978059/acute-myeloid-leukemia-cells-require-6-phosphogluconate-dehydrogenase-for-cell-growth-and-nadph-dependent-metabolic-reprogramming
#19
Haymanti Bhanot, Ellen L Weisberg, Mamatha M Reddy, Atsushi Nonami, Donna Neuberg, Richard M Stone, Klaus Podar, Ravi Salgia, James D Griffin, Martin Sattler
Acute myeloid leukemia (AML) cells are highly dependent on glycolytic pathways to generate metabolic energy and support cell growth, hinting at specific, targetable vulnerabilities as potential novel targets for drug development. Elevated levels of NADPH, a central metabolic factor involved in redox reactions, are common in myeloid leukemia cells, but the significance or biochemical basis underlying this increase is unknown. Using a small molecule analog that efficiently inhibits NADPH-producing enzymes, we found that AML cells require NADPH homeostasis for cell growth...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28969664/perspective-on-the-dynamics-of-cancer
#20
REVIEW
Youcef Derbal
BACKGROUND: The genetic diversity of cancer and the dynamic interactions between heterogeneous tumor cells, the stroma and immune cells present daunting challenges to the development of effective cancer therapies. Although cancer biology is more understood than ever, this has not translated into therapies that overcome drug resistance, cancer recurrence and metastasis. The future development of effective therapies will require more understanding of the dynamics of homeostatic dysregulation that drives cancer growth and progression...
October 3, 2017: Theoretical Biology & Medical Modelling
keyword
keyword
109714
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"