Matheus Naia Fioretto, Ketlin Thassiani Colombelli, Cecilia Luvizutti Ferreira da Silva, Sérgio Alexandre Alcantara Dos Santos, Ana Carolina Lima Camargo, Flávia Bessi Constantino, Luiz Marcos Frediani Portela, Ariana Musa de Aquino, Luisa Annibal Barata, Renato Mattos, Wellerson Rodrigo Scarano, Elena Zambrano, Luis Antonio Justulin
Maternal malnutrition can alter developmental biology, programming health and disease in offspring. The increase in sugar consumption during the peripubertal period, a worldwide concern, also affects health through adulthood. Studies have shown that maternal exposure to a low protein diet (LPD) is associated with an increase in prostate disease with aging. However, the combined effects of maternal LPD and early postnatal sugar consumption on offspring prostate disorders were not investigated. The effects on aging were evaluated using a maternal gestational model with lactational LPD (6% protein) and sugar consumption (10%) from postnatal day (PND) 21-90, associating the consequences on ventral prostate (VP) rats morphophysiology on PND540...
March 29, 2024: Molecular and Cellular Endocrinology