keyword
MENU ▼
Read by QxMD icon Read
search

Curcumin

keyword
https://www.readbyqxmd.com/read/28747775/curcumin-and-curcuma-longa-l-extract-ameliorate-lipid-accumulation-through-the-regulation-of-the-endoplasmic-reticulum-redox-and-er-stress
#1
Hwa-Young Lee, Seung-Wook Kim, Geum-Hwa Lee, Min-Kyung Choi, Han-Wool Chung, Yong-Chul Lee, Hyung-Ryong Kim, Ho Jeong Kwon, Han-Jung Chae
For this study, we examined the effects of curcumin against acute and chronic stress, paying specific attention to ROS. We also aimed to clarify the differences between acute and chronic stress conditions. We investigated the effects of curcumin against acute stress (once/1 day CCl4 treatment) and chronic-stress (every other day/4week CCl4 treatment). Compared with acute stress, in which the antioxidant system functioned properly and aspartate transaminase (AST) and ROS production increased, chronic stress increased AST, alanine aminotransferase (ALT), hepatic enzymes, and ROS more significantly, and the antioxidant system became impaired...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28746888/curcumin-loaded-chitosan-carboxymethyl-starch-montmorillonite-bio-nanocomposite-for-reduction-of-dental-bacterial-biofilm-formation
#2
Shabnam Jahanizadeh, Fatemeh Yazdian, Azam Marjani, Meisam Omidi, Hamid Rashedi
A novel bio nanocomposite of Carboxymethyl Starch (CMS)-Chitosan (CS)-Montmorillonite (MMT) was developed for Curcumin delivery. To improve Curcumin entrapment into Cs-CMS-MMT, different ratios of Chitosan (Cs), Carboxymethyl Starch (CMS) and MMT were used. Particle size and Curcumin entrapment efficiency (EE) were highly affected by different formulation variables. Polysaccharide concentration, Cs-CMS ratio and sonication time had significant effect on particle size. MMT addition enhanced the entrapment efficiency...
July 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28745768/the-sos-chromotest-applied-for-screening-plant-antigenotoxic-agents-against-ultraviolet-radiation
#3
J L Fuentes, A García Forero, N Quintero Ruiz, C A Prada Medina, N Rey Castellanos, D A Franco Niño, D A Contreras García, Y Córdoba Campo, E E Stashenko
In this work, we investigated the usefulness of the SOS Chromotest for screening plant antigenotoxic agents against ultraviolet radiation (UV). Fifty Colombian plant extracts obtained by supercritical fluid (CO2) extraction, twelve plant extract constituents (apigenin, carvacrol, β-caryophyllene, 1,8-cineole, citral, p-cymene, geraniol, naringenin, pinocembrin, quercetin, squalene, and thymol) and five standard antioxidant and/or photoprotective agents (curcumin, epigallocatechin gallate, resveratrol, α-tocopherol, and Trolox®) were evaluated for their genotoxicity and antigenotoxicity against UV using the SOS Chromotest...
July 26, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28745498/curcumin-and-salsalate-suppresses-colonic-inflammation-and-pro-carcinogenic-signaling-in-high-fat-fed-azoxymethane-treated-mice
#4
Xian Wu, Anna C Pfalzer, Gar Yee Koh, Sanyuan Tang, Jimmy W Crott, Michael J Thomas, Mohsen Meydani, Joel B Mason
High fat diets (HFD) and excess adiposity increase pro-inflammatory cytokines in the colon, altering gene expression in a manner that promotes the development of colorectal cancer (CRC). Thus, compounds that reduce this biochemical inflammation are potential chemopreventive agents. Curcumin (CUR), a dietary polyphenol, and salsalate (SAL), a non-steroidal anti-inflammatory drug, are both anti-inflammatory. We investigated the inhibitory effects of CUR with or without SAL on inflammatory cytokines and pro-carcinogenic signaling in azoxymethane (AOM)-treated A/J mice...
July 26, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28745492/amphiphilic-polysaccharide-block-copolymers-for-ph-responsive-micellar-nanoparticles
#5
Benjamin B Breitenbach, Ira Schmid, Peter R Wich
A full polysaccharide amphiphilic block copolymer was prepared from end group-functionalized dextrans using copper mediated azide-alkyne click chemistry. Sufficient modification of the reducing end in both blocks was achieved by microwave-enhanced reductive amination in a borate-buffer/methanol solvent system. The combination of a hydrophilic dextran block with a hydrophobic acetalated dextran block results in an amphiphilic structure that turns water-soluble upon acid treatment. The material has a low CMC and self-assembles in water to spherical micellar nanoparticles...
July 26, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28742369/effect-of-curcumin-addition-on-the-adsorption-and-transport-of-a-cationic-dye-across-dppg-popg-liposomes-probed-by-second-harmonic-spectroscopy
#6
Gopal K Varshney, Srinivas R Kintali, Kaustuv Das
The effect of addition of Curcumin on the adsorption and transport characteristics of a cationic dye, (LDS+), across negatively charged bilayers composed of POPG and DPPG lipids were investigated by the interface selective Second Harmonic (SH) spectroscopic technique. Curcumin induced changes in the SH electric field signal of the LDS+ ions (E2ω (LDS+)) were observed to depend critically on the bilayer acyl chain saturation/un-saturation ratio (S/U). Following earlier works, the increase in the E2ω (LDS+) signal is attributed to the release of the Na+ counter-ions present in the head-group region of the bilayer by Curcumin and the decay of the E2ω (LDS+) signal is attributed to the bilayer intercalated state of Curcumin...
July 25, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28742327/amphiphilic-peptide-nanorods-based-on-oligo-phenylalanine-as-a-biocompatible-drug-carrier
#7
Su Jeong Song, Seulgi Lee, Kyoung-Seok Ryu, Joon Sig Choi
Peptide nanostructure has been widely explored for drug delivery systems in recent studies. Peptides possess comparatively lower cytotoxicity and are more efficient than polymeric carriers. Here, we propose a peptide nanorod system, composed of an amphiphilic oligo-peptide RH3F8 (Arg-His3-Phe8) as a drug delivery carrier. Arginine is an essential amino acid in typical cell penetration peptides, and histidine induces endo/lysosomal escape because of its proton sponge effect. Phenylalanine is introduced to provide rich hydrophobicity for stable self-assembly and drug encapsulation...
July 25, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28741978/effects-of-co-exposure-to-atrazine-and-ethanol-on-the-oxidative-damage-of-kidney-and-liver-in-wistar-rats
#8
Sunny O Abarikwu, Queen C Duru, Rex-Clovis C Njoku, Benjamin A Amadi, Aseme Tamunoibuomie, Enebimoere Keboh
Both ethanol (EtoH) and atrazine (ATZ) have hepatic and nephro-toxic effects in rats. In the present study, the toxicity of EtoH (5 g kg(-1)) on the kidney and liver in the absence or in the presence of different doses of ATZ (50, 100, 300 mg kg(-1)) was evaluated after 21 days in rats. Results showed that the mixture effects on catalase and superoxide dismutase activities were more severe in both tissues compared to EtoH alone, especially as the dose of ATZ was increased. Hepatic malondialdehyde level (an index of lipid peroxidation) was increased from 20...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28741924/ultrasound-responsive-polymeric-micelles-for-sonoporation-assisted-site-specific-therapeutic-action
#9
Pengying Wu, Yali Jia, Fei Qu, Yue Sun, Pan Wang, Kun Zhang, Chuanshan Xu, Quanhong Liu, Xiaobing Wang
Targeting drug delivery remains a challenge in various disease treatment including cancer. The local drug deposit could be greatly enhanced by some external stimuli-responsive systems. Here we develop pluronic P123/F127 polymeric micelles (M) encapsulating curcumin (Cur) that are permeabilized directly by focused ultrasound, in which ultrasound triggers drug release. Tumor preferential accumulation and site-specific sonochemotherapy were then evaluated. Cur-loaded P123/F127 mixed micelles (Cur-M) exhibited longer circulating time and increased cellular uptake compared to free Cur...
July 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28741112/investigation-of-naphthofuran-moiety-as-potential-dual-inhibitor-against-bace-1-and-gsk-3%C3%AE-molecular-dynamics-simulations-binding-energy-and-network-analysis-to-identify-first-in-class-dual-inhibitors-against-alzheimer-s-disease
#10
Akhil Kumar, Gaurava Srivastava, Swati Srivastava, Seema Verma, Arvind S Negi, Ashok Sharma
BACE-1 and GSK-3β are potential therapeutic drug targets for Alzheimer's disease. Recently, both the targets received attention for designing dual inhibitors for Alzheimer's disease. Until now, only two-scaffold triazinone and curcumin have been reported as BACE-1 and GSK-3β dual inhibitors. Docking, molecular dynamics, clustering, binding energy, and network analysis of triazinone derivatives with BACE-1 and GSK-3β was performed to get molecular insight into the first reported dual inhibitor. Further, we designed and evaluated a naphthofuran series for its ability to inhibit BACE-1 and GSK-3β with the computational approaches...
August 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28739698/highly-eribulin-resistant-kbv20c-oral-cancer-cells-can-be-sensitized-by-co-treatment-with-the-third-generation-p-glycoprotein-inhibitor-elacridar-at-a-low-dose
#11
Yujin Park, Ji-Yeon Son, Byung-Mu Lee, Hyung Sik Kim, Sungpil Yoon
BACKGROUND/AIM: Eribulin mesylate, also called Halaven® (HAL), was recently developed as a microtubule-targeting drug and is used in the clinic for resistant or metastatic cancer. Previously, we showed that P-glycoprotein (P-gp)-overexpressing KBV20C oral cancer cells are highly resistant to HAL compared to sensitive KB cells. This qualitative study was designed to identify specific P-gp inhibitors that increase the sensitivity of highly resistant cancer cells to HAL. MATERIALS AND METHODS: In order to identify functional P-gp inhibitors, HAL-treated KBV20C cells were co-treated with P-gp inhibitors, verapamil, elacridar, cyclosporine A, mitotane, piperine, fumagillin, curcumin, indomethacin, probenecid, sulindac, tesmilifene, and C-4...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739530/curcumin-modulates-endothelial-permeability-and-monocyte-transendothelial-migration-by-affecting-endothelial-cell-dynamics
#12
Laurent-Emmanuel Monfoulet, Sylvie Mercier, Dominique Bayle, Radu Tamaian, Nicolas Barber-Chamoux, Christine Morand, Dragan Milenkovic
Curcumin is a phenolic compound that exhibits beneficial properties for cardiometabolic health. We previously showed that curcumin reduced the infiltration of immune cells into the vascular wall and prevented atherosclerosis development in mice. This study aimed to investigate the effect of curcumin on monocyte adhesion and transendothelial migration (TEM) and to decipher the underlying mechanisms of these actions. Human umbilical vein endothelial cells (HUVECs) were exposed to curcumin (0.5-1μM) for 3hours prior to their activation by Tumor Necrosis Factor alpha (TNF-α)...
July 21, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28738425/preparation-and-characterization-of-pegylated-iron-oxide-gold-nanoparticles-for-delivery-of-sulforaphane-and-curcumin
#13
Hossein Danafar, Ali Sharafi, Sonia Askarlou, Hamidreza Kheiri Manjili
Natural products have been used for the treatment of various diseases such as cancer. Curcumin (CUR) and sulforaphane (SF) have anti-cancer effects, but their application is restricted because of their low water solubility and poor oral bioavailability. To improve the bioavailability and solubility of SF and CUR, we performed an advanced delivery of SF and CUR with PEGylated gold coated Fe3O4 magnetic nanoparticles (PEGylated Fe3O4@Au NPs) to endorse SF and CUR maintenance as an effective and promising antitumor drugs...
July 24, 2017: Drug Research
https://www.readbyqxmd.com/read/28737462/co-delivery-of-hydrophilic-and-hydrophobic-drugs-by-micelles-a-new-approach-using-drug-conjugated-peg-pcl-nanoparticles
#14
H Danafar, K Rostamizadeh, S Davaran, M Hamidi
Co-delivery strategy has been proposed to minimize the amount of each drug and to achieve the synergistic effect for cancer therapies. A conjugate of the antitumor drug, doxorubicin, with diblock methoxy poly (ethylene glycol)-poly caprolactone (mPEG-PCL) copolymer was synthesized by the reaction of mPEG-PCL copolymer with doxorubicin in the presence of p-nitrophenylchloroformate. The conjugated copolymer was characterized in vitro by (1)H NMR, FTIR, DSC and GPC techniques. Then, the doxorubicin conjugated mPEG-PCL(DOX-mPEG-PCL) was self-assembled into micelles in the presence of curcumin in aqueous solution...
July 24, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28736282/imiquimod-induced-psoriasis-like-inflammation-in-differentiated-human-keratinocytes-its-evaluation-using-curcumin
#15
Sandeep R Varma, Thiyagarajan O Sivaprakasam, Abheepsa Mishra, Sunil Prabhu, Rafiq M, Rangesh P
Psoriasis is considered to be a systemic disease of immune dysfunction. It is still unclear what triggers the inflammatory cascade associated with psoriasis but recent evidences suggest the vital role of IL-23/IL-17A cytokine axis in etiology of psoriasis. Several studies have been conducted in psoriatic-like animal models but ethical issues and complexity surrounding it halts the screening of new anti-psoriatic drug candidates. Hence, in this study, we developed a new in-vitro model for psoriasis using imiquimod (IMQ) induced differentiated HaCaT cells which could be used for screening of new anti-psoriatic drug candidates...
July 20, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28736128/the-effect-of-pro-nanolipospheres-pnl-formulation-containing-natural-absorption-enhancers-on-the-oral-bioavailability-of-delta-9-tetrahydrocannabinol-thc-and-cannabidiol-cbd-in-a-rat-model
#16
Irina Cherniakov, Dvora Izgelov, Abraham J Domb, Amnon Hoffman
The lipophilic phytocannabinoids cannabidiol (CBD) and Δ(9)-tetrahydrocannabinol (THC) show therapeutic efficacy in various medical conditions. Both molecules are poorly water soluble and subjected to extensive first pass metabolism in the gastrointestinal tract, leading to a limited oral bioavailability of approximately 9%. We have developed an advanced lipid based Self-Emulsifying Drug Delivery System termed Advanced Pro-NanoLiposphere (PNL) pre-concentrate. The PNL is composed of lipid and emulsifying excipients of GRAS status and are known to increase solubility and reduce Phase I metabolism of lipophilic active compounds...
July 20, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28735823/comparison-of-remicade-to-curcumin-for-the-treatment-of-crohn-s-disease-a-systematic-review
#17
REVIEW
Allaire Schneider, Ivy Hossain, Julia VanderMolen, Kara Nicol
OBJECTIVE: The aim of this study was to review the literature to assess if there is evidence to support the use of Curcumin as a safe complementary therapy in treating Crohn's Disease (CD) in conjunction with Remicade. DESIGN: Systematic searches were performed by three researchers using electronic databases (ProQuest Medical Library, CINAHL Complete, and PUBMED) to locate and identify articles to meet a predetermined set of inclusion criteria. Specifically full text, peer-reviewed articles published after 2007 were included if they studied human participants 18 years or older...
August 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28735008/trehalose-induced-structural-modulation-of-bovine-serum-albumin-at-ambient-temperature
#18
Ahana Das, Pijush Basak, Rudradip Pattanayak, Turban Kar, Rajib Majumder, Debadrita Pal, Anindita Bhattacharya, Maitree Bhattacharyya, Samudra Prosad Banik
Trehalose is a well-known protein stabilizing osmolyte. The present study has been designed to understand the interaction of trehalose with BSA at ambient temperature. Steady state fluorescence and life-time analysis along with CD, DLS and ITC have been employed to show that trehalose causes surface-associated structural perturbation of BSA to promote its compaction. Trehalose at 0.1M concentration resulted in increased solvent exposure of one of the two tryptophans of BSA with a 5nm redshift in emission and enhanced susceptibility to acrylamide quenching with an increase in KSV from 2...
July 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28734960/pharmacokinetic-interactions-of-curcuminoids-with-conventional-drugs-a-review
#19
REVIEW
Roodabeh Bahramsoltani, Roja Rahimi, Mohammad Hosein Farzaei
ETHNOPHARMACOLOGICAL RELEVANCE: Herb-drug interactions are of great concern in health practices. Curcumin is a natural polyphenol extracted from turmeric, a spice widely used all over the world. Curcumin is clinically used due to its acceptable safety profile and therapeutic efficacy. AIM OF THE STUDY: Current paper aims to highlight the effect of curcumin on concomitantly used drugs. METHODS: Electronic databases including PubMed, Scopus and Science Direct were searched with the keywords "curcumin" in the title/abstract and "drug interaction," "drug metabolism," "cytochrome," "P-glycoprotein" and "P450" in the whole text...
July 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28734166/naturally-occurring-immunomodulators-with-antitumor-activity-an-insight-on-their-mechanisms-of-action
#20
REVIEW
Shimaa Ibrahim Abdelmonym Mohamed, Ibrahim Jantan, Md Areeful Haque
Natural products with immunomodulatory activity are widely used in treatment of many diseases including autoimmune diseases, inflammatory disorders in addition to cancer. They gained a great interest in the last decades as therapeutic agents since they provide inexpensive and less toxic products than the synthetic chemotherapeutic agents. Immunomodulators are the agents that have the ability to boost or suppress the host defense response that can be used as a prophylaxis as well as in combination with other therapeutic modalities...
July 19, 2017: International Immunopharmacology
keyword
keyword
1097
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"