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https://www.readbyqxmd.com/read/28639178/effective-skin-cancer-treatment-by-topical-co-delivery-of-curcumin-and-stat3-sirna-using-cationic-liposomes
#1
Anup Jose, Suman Labala, Kunal Manoj Ninave, Sudeep Kumar Gade, Venkata Vamsi Krishna Venuganti
The aim of the present study was to evaluate the effectiveness of iontophoretic co-delivery of curcumin and anti-STAT3 siRNA using cationic liposomes against skin cancer. Curcumin was encapsulated in DOTAP-based cationic liposomes and then complexed with STAT3 siRNA. This nanocomplex was characterized for the average particle size, zeta-potential, and encapsulation efficiency. The cell viability studies in B16F10 mouse melanoma cells have shown that the co-delivery of curcumin and STAT3 siRNA significantly (p < 0...
June 21, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28639101/prevention-and-treatment-of-cancer-targeting-chronic-inflammation-research-progress-potential-agents-clinical-studies-and-mechanisms
#2
REVIEW
Yong Zhang, Weijia Kong, Jiandong Jiang
Numerous experimental and clinical studies indicate that chronic inflammation is closely related to the initiation, progression, and spread of cancer, in which proinflammatory cytokines, such as interleukin (IL)-6, IL-1β, and tumor necrosis factor-α (TNF-α), and transcription factors, such as nuclear factor-κB (NF-κB), and signal transducer and activator of transcription 3 (STAT3), play pivotal roles. Stimulated by proinflammatory cytokines, NF-κB and STAT3 can modulate the expression of target genes, most of which are oncogenic ones, and promote the survival, proliferation, invasion, and metastasis of cancer cells...
May 29, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28638626/effects-of-liposomal-curcumin-on-five-opportunistic-bacterial-strains-found-in-the-equine-hindgut-preliminary-study
#3
S D Bland, E B Venable, J L McPherson, R L Atkinson
BACKGROUND: The horse intestinal tract is sensitive and contains a highly complex microbial population. A shift in the microbial population can lead to various issues such as inflammation and colic. The use of nutraceuticals in the equine industry is on the rise and curcumin is thought to possess antimicrobial properties that may help to minimize the proliferation of opportunistic bacteria. METHODS: Four cecally-cannulated horses were utilized to determine the optimal dose of liposomal-curcumin (LIPC) on reducing Streptococcus bovis/equinus complex (SBEC), Escherichia coli K-12, Escherichia coli general, Clostridium difficile, and Clostridium perfringens in the equine hindgut without adversely affecting cecal characteristics...
2017: Journal of Animal Science and Technology
https://www.readbyqxmd.com/read/28637240/tfeb-activation-restores-migration-ability-to-tsc1-deficient-adult-neural-stem-progenitor-cells
#4
Alessandro Magini, Alice Polchi, Danila Di Meo, Giuseppina Mariucci, Krizia Sagini, Federico De Marco, Tommaso Cassano, Stefano Giovagnoli, Diego Dolcetta, Carla Emiliani
Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder caused by mutations in either of two genes, TSC1 or TSC2, resulting in the constitutive activation of the mammalian target of rapamycin complex 1 (mTORC1). mTOR inhibitors are now considered the treatment of choice for TSC disease. A major pathological feature of TSC is the development of subependymal giant cell astrocytomas (SEGAs) in the brain. Nowadays, it is thought that SEGAs could be a consequence of aberrant aggregation and migration of neural stem/progenitor cells (NSPCs)...
June 14, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28635562/nanoformulated-natural-therapeutics-for-management-of-streptozotocin-induced-diabetes-potential-use-of-curcumin-nanoformulation
#5
Yousra M El-Far, Mahmoud M Zakaria, Mahmoud M Gabr, Amal M El Gayar, Laila A Eissa, Ibrahim M El-Sherbiny
AIM: The goal of this study was to improve curcumin (CUR) aqueous solubility and bioavailability via nanoformulation, and then study its activity and mechanism of action as an antidiabetic agent. METHODS: CUR-loaded pluronic nanomicelles (CURnp) were prepared and characterized. Biochemical assessments were performed as well as histological, confocal and RTPCR studies on pancreatic target tissues. RESULTS: CURnp with a diameter of 333 ± 6 nm and ζ potential of -26...
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28634058/apoptotic-gene-expression-profiles-and-dna-damage-levels-in-rat-liver-treated-with-perfluorooctane-sulfonate-and-protective-role-of-curcumin
#6
Dilek Eke, Ayla Çelik, Bertan Yilmaz, Nurcan Aras, Sabriye Kocatürk Sel, Davut Alptekin
Perfluorinated compounds (PFCs) such as PFOS and PFOA, are xenobiotics that can be detected worldwide in the environment and humans. PFOS (C8F17SO3(-)) is a fluorinated organic compound has been used for decades in industrial and commercial products. We investigated the genotoxic and apoptotic impact of PFOS in rat liver using comet assay, micronucleus test and apoptotic gene expression methods for caspase 3, caspase 8 and the protective role of curcumin on the PFOS- induced damage under chronic exposure. In this study, rats were treated either with three different PFOS doses only (0...
June 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28633845/intensification-of-extraction-of-curcumin-from-curcuma-amada-using-ultrasound-assisted-approach-effect-of-different-operating-parameters
#7
S R Shirsath, S S Sable, S G Gaikwad, S H Sonawane, D R Saini, P R Gogate
Curcumin, a dietary phytochemical, has been extracted from rhizomes of Curcuma amada using ultrasound assisted extraction (UAE) and the results compared with the conventional extraction approach to establish the process intensification benefits. The effect of operating parameters such as type of solvent, extraction time, extraction temperature, solid to solvent ratio, particle size and ultrasonic power on the extraction yield have been investigated in details for the approach UAE. The maximum extraction yield as 72% was obtained in 1h under optimized conditions of 35°C temperature, solid to solvent ratio of 1:25, particle size of 0...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28633826/optimization-and-characterization-of-ultrasound-assisted-preparation-of-curcumin-loaded-solid-lipid-nanoparticles-application-of-central-composite-design-thermal-analysis-and-x-ray-diffraction-techniques
#8
Elham Sadati Behbahani, Mehrorang Ghaedi, Mohammadreza Abbaspour, Kobra Rostamizadeh
This study is devoted to preparation of novel solid lipid nanoparticles (SLNs) for the encapsulation of curcumin which is produced by micro-emulsion and ultrasonication using stearic acid and tripalmitin as solid lipids, tween80 and span80 as surfactants. The relation between particle size and entrapment efficiency of the produced SLNs was operated by central composite design (CCD) under response likes surface method (RSM). The variables including the ratio of lipids (X1), the ratio of surfactants (X2), drug/lipid ratio (X3), time of sonication (X4) and time of homogenization (X5)...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28633599/mechanism-of-deltamethrin-induced-thymic-and-splenic-toxicity-in-mice-and-its-protection-by-piperine-and-curcumin-in-vivo-study
#9
Anoop Kumar, Dinakar Sasmal, Neelima Sharma
Deltamethrin (DLM) is a well-known pyrethroid insecticide which is widely used in the agriculture and home pest control due to restriction on the sale of organophosphate. DLM induced apoptosis is well known but its mechanism is still unclear. This study has been designed to find out its mechanism of apoptosis with the help of computational methods along with in vivo methods. The QikProp and ProTox results have shown that DLM has good oral absorption. The docking results reveal that DLM has a strong binding affinity toward the CD4, CD8, CD28 and CD45 receptors...
February 28, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28633516/synthesis-of-curcumin-glycosides-with-enhanced-anti-cancer-properties-using-one-pot-multi-enzyme-glycosylation-technique
#10
Rit Bahadur Gurung, So Youn Gong, Tuoi Thi Le, Dipesh Dhakal, Narae Jung, Hye Jin Jung, Tae Jin Oh, Jae Kyung Sohng
Curcumin is a natural polyphenolic compound, widely acclaimed for its antioxidant, anti-inflammatory, antibacterial and anti-cancerous properties. However, its use has been limited due to low-aqueous solubility and poor bioavailability, rapid clearance and low cellular uptake. In order to assess the effect of glycosylation on pharmacological properties of curcumin, the one-pot multi-enzyme (OPME) chemoenzymatic glycosylation reactions with UDP-α-D-glucose or UDP-α-D-2-deoxyglucose as donor substrate were employed...
June 21, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28629803/development-of-mpc-dpa-polymeric-nanoparticle-systems-for-inhalation-drug-delivery-applications
#11
Abdul Khaliq Elzhry Elyafi, Guy Standen, Steven T Meikle, Andrew L Lewis, Jonathan P Salvage
Inhalation of nanoparticles for pulmonary drug delivery offers the potential to harness nanomedicine formulations of emerging therapeutics, such as curcumin, for treatment of lung cancer. Biocompatible nanoparticles composed of poly(2-methacryloyloxyethyl phosphorylcholine)-b-poly(2-(diisopropylamino)ethyl methacrylate) (MPC-DPA) have been shown to be suitable nanocarriers for drugs, whilst N-trimethyl chitosan chloride (TMC) coating of nanoparticles has been reported to further enhance their cellular delivery efficacy; the combination of the two has not been previously investigated...
June 16, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28629042/functionalization-of-zno-nanoparticles-by-3-mercaptopropionic-acid-for-aqueous-curcumin-delivery-synthesis-characterization-and-anticancer-assessment
#12
Seyed-Behnam Ghaffari, Mohammad-Hossein Sarrafzadeh, Zahra Fakhroueian, Shadab Shahriari, M Reza Khorramizadeh
Inherent biocompatibility and stability of zinc oxide nanoparticles (ZnO-NPs) and their biomedical potentials make them an emerging candidate for drug delivery. The aim of this study was to develop and assess a simple procedure for surface functionalization of ZnO-NPs by 3-mercaptopropionic acid (MPA) for water-soluble curcumin delivery. Carboxyl-terminated ZnO nanoparticles were successfully made using ZnCl2 and NaOH in the presence of MPA. The functional groups were activated by 1,1'-carbonyldiimidazole (CDI) and the curcumin bonding was carried out at room temperature for 24h...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628927/curcumin-promotes-apoptosis-of-activated-hepatic-stellate-cells-by-inhibiting-protein-expression-of-the-myd88-pathway
#13
Ya-Jun He, Kenny Kuchta, Yan-Mei Deng, Silke Cameron, Yu Lin, Xu-You Liu, Guo-Ron Ye, Xia Lv, Yuta Kobayashi, Jian-Chang Shu
Activation and proliferation of hepatic stellate cells (HSC) play an important role in the progress of liver fibrosis. HSC activation occurs in response to inflammatory cytokines, cellular interactions with immune cells, and morphogenetic signals. The literature hints to a role of the adaptor protein MyD88 in fibrosis. Although curcumin has been shown to exert inhibitory effects on the proliferation of HSC in vitro, its influence on the MyD88 pathway in HSC has remained unclear. Here, we investigated whether curcumin accelerates apoptosis of HSC through the MyD88 pathway...
June 19, 2017: Planta Medica
https://www.readbyqxmd.com/read/28628644/targeting-multiple-pro-apoptotic-signaling-pathways-with-curcumin-in-prostate-cancer-cells
#14
Mariela Rivera, Yanilda Ramos, Madeline Rodríguez-Valentín, Sheila López-Acevedo, Luis A Cubano, Jin Zou, Qiang Zhang, Guangdi Wang, Nawal M Boukli
Curcumin, an extract from the turmeric rhizome (Curcuma longa), is known to exhibit anti-inflammatory, antioxidant, chemopreventive and antitumoral activities against aggressive and recurrent cancers. Accumulative data indicate that curcumin may induce cancer cell death. However, the detailed mechanism underlying its pro-apoptotic and anti-cancer effects remains to be elucidated. In the present study, we examined the signaling pathways triggered by curcumin, specifically, the exact molecular mechanisms of curcumin-induced apoptosis in highly metastatic human prostate cancer cells...
2017: PloS One
https://www.readbyqxmd.com/read/28628020/-study-of-cytotoxic-activity-of-methanol-extracts-of-the-endemic-plant-of-the-genus-erysimum-of-the-adjarian-floristic-district-of-georgia
#15
D Beridze, M Metreveli, M Joxadze, K Bakuridze, D Berashvili, A Bakuridze
According to the results, investigated methanolic extracts of endemic plant from Adjarian floristic region of Georgia do not have specific cytotoxicity against the cell lines of breast adenocarcinoma MCF-7 human, which is typical, e.g., for plant pigment curcumin. At the same time, the high specific cytotoxicity of 2 and 3 fractions towards keratinocytes gives reason for considering endemic plant extracts, of Adjarian floristic region of Georgia, as a potential pharmacological means for topical treatment of pathologies caused by increased proliferation of keratinocytes, such as psoriasis...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28627598/curcumin-exerts-its-tumor-suppressive-function-via-inhibition-of-nedd4-oncoprotein-in-glioma-cancer-cells
#16
Xue Wang, Jiaojiao Deng, Jinxia Yuan, Xin Tang, Yuelong Wang, Haifeng Chen, Yi Liu, Liangxue Zhou
Glioblastoma is the most common brain cancer in adults. It represents one of the top ten malignant tumors with an average survival time of nine months despite treatments with surgery, radiotherapy and chemotherapy. Curcumin is a phytochemical turmeric isolated from root of the Curcuma longa plant. Accumulating evidence have proved that curcumin targets numerous cancer signaling pathways. The E3 ubiquitin ligase NEDD4, neural precursor cell expressed developmentally downregulated protein 4, is frequently overexpressed in various cancers...
June 8, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28627596/regulation-of-type-ii-collagen-matrix-metalloproteinase-13-and-cell-proliferation-by-interleukin-1%C3%AE-is-mediated-by-curcumin-via-inhibition-of-nf-%C3%AE%C2%BAb-signaling-in-rat-chondrocytes
#17
Jian Wang, Jie Ma, Jian-Hua Gu, Fu-Yong Wang, Xiu-Shuai Shang, Hai-Rong Tao, Xiang Wang
Curcumin possesses strong anti-inflammatory, anti-rheumatoid and anti-oxidative activities, and has the potential to inhibit nuclear factor‑κB (NF‑κB) signaling. Cartilage damage in osteoarthritis (OA) is largely mediated by interleukin-1β (IL-1β) via activation of various transcription factors, including NF‑κB and activator protein‑1. The aim of the present study was to determine whether IL‑1β induces matrix metalloproteinase-13 (MMP-13) expression and inhibits type II collagen expression, as well as to examine whether cell proliferation may be inhibited by curcumin through the inhibition of NF‑κB signaling...
June 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28625265/-protective-effect-of-curcumin-on-hepatocytes-in-rats-with-sepsis
#18
Haiyan Yin, Minshan Qiu, Dan He, Rui Zhang, Pei Tao, Yanwen Liang, Yuegui Yang, Yanqi Guo, Xiaoling Ye
OBJECTIVE: To investigate the protective effect of curcumin on hepatocytes in rats with sepsis. METHODS: Eighty healthy male Sprague-Dawley (SD) rats were randomly divided into sham operation group, sepsis group, Xuebijing group and curcumin group (20 rats in each group) according to the random number table method. The animal model of sepsis was established by cecal ligation and puncture (CLP). In the sham operation group, the cecum was removed only after the operation...
February 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28624736/fluorescence-of-tautomeric-forms-of-curcumin-in-different-ph-and-biosurfactant-rhamnolipids-systems-application-towards-on-off-ratiometric-fluorescence-temperature-sensing
#19
Zeinab Moussa, Mazhar Chebl, Digambara Patra
Medicinal properties of curcumin are widely getting realized. For its applicability as a hydrophobic drug molecule and food spice interaction of curcumin with rhamnolipids, a biosurfactant, bears importance. Here we have explored interaction of curcumin with rhamnolipids biosurfactant and its aggregation behavior. The impact of pH on critical micelle concentration (cmc) of rhamnolipids has been studied using fluorescence of curcumin and found that cmc of rhamnolipids increases with increase in pH of the medium...
June 11, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28624378/glucose-triggered-enhanced-solubilisation-release-and-cytotoxicity-of-poorly-water-soluble-anti-cancer-drugs-fromt1307-micelles
#20
Pooja Patidar, Sadafara A Pillai, Urjita Sheth, Pratap Bahadur, Anita Bahadur
Tetronic(®) 1307 (here after written as T1307) is a hydrophilic ethylene oxide-propylene oxide (EO-PO) star block copolymer with long EO chains (Total MW- 18000 and 70% EO). Although biocompatible, its use as a nanocarrier is restricted owing to its high critical micelle concentration (CMC) and temperature (CMT). We examined if the addition of glucose, a common pharmaceutical ingredient promotes micellization. Scattering and thermal studies show formation of stable unimodal micelles and cloud point (CP) decreased linearly...
June 15, 2017: Journal of Biotechnology
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