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https://www.readbyqxmd.com/read/28920531/role-of-kr%C3%A3-ppel-like-factor-4-in-the-maintenance-of-chemoresistance-of-anaplastic-thyroid-cancer
#1
Su In Lee, Dae Kyoung Kim, Eun Jin Seo, Eun Jung Choi, Yang Woo Kwon, Il Ho Jang, Jin Choon Lee, Hyun Yul Kim, Minho Shong, Jae Ho Kim, Seong-Jang Kim
BACKGROUND: Anaplastic thyroid cancer (ATC) has a very poor prognosis due to its aggressive nature and resistance to conventional treatment. Radiotherapy and chemotherapy are not fully effective because of the undifferentiated phenotype and enhanced drug resistance of ATC. The objective of this study was to evaluate the involvement of Krüppel-like factor 4 (KLF4), a stemness-associated transcription factor, in the undifferentiated phenotype and drug resistance of ATC. METHODS: ATC cells were compared with papillary thyroid cancer cells in drug resistance and gene expression...
September 16, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28919333/status-of-the-effectiveness-of-contact-lens-disinfectants-in-malaysia-against-keratitis-causing-pathogens
#2
Farhat Abjani, Naveed Ahmed Khan, Suk Yul Jung, Ruqaiyyah Siddiqui
The aim of this study was (i) to assess the antimicrobial effects of contact lens disinfecting solutions marketed in Malaysia against common bacterial eye pathogens and as well as eye parasite, Acanthamoeba castellanii, and (ii) to determine whether targeting cyst wall would improve the efficacy of contact lens disinfectants. Using ISO 14729 Stand-Alone Test for disinfecting solutions, bactericidal and amoebicidal assays of six different contact lens solutions including Oxysept(®), AO SEPT PLUS, OPTI-FREE(®) pure moist(®), Renu(®) fresh™, FreshKon(®) CLEAR and COMPLETE RevitaLens™ were performed using Manufacturers Minimum recommended disinfection time (MRDT)...
September 14, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28919126/low-dose-ct-for-the-diagnosis-of-appendicitis-in-adolescents-and-young-adults-locat-a-pragmatic-multicentre-randomised-controlled-non-inferiority-trial
#3
Hyuk Jung Kim, Byeong Geon Jeon, Chong Kun Hong, Kye Won Kwon, Seung Bong Han, Soya Paik, Suk Ki Jang, Young Rock Ha, Young Sik Kim, Min Hee Lee, Boem Ha Yi, Eung Jin Shin, Hae Kyung Lee, Hee Kyung Kim, Ho Jung Kim, Jae Hyung Choi, Young Soon Cho, Min-Jeong Kim, Dong Kyu Kim, Ji-Young Choe, Kyueng-Whan Min, Man Sup Lim, Sang Ook Ha, Sang Woo Lim, Youdong Sohn, Young Hwan Lee, Ji Hoon Park, Bon Seung Gu, Hye Seung Lee, Jae Hyuk Lee, Ji Ye Sim, Joonghee Kim, Kyoung Ho Lee, Kyuseok Kim, Soyeon Ahn, Sung-Bum Kang, Yoon Jin Lee, You Hwan Jo, Young Hoon Kim, Yousun Ko, Seung Joon Choi, Bohyung Song, Byung Ho Goh, Chaesuk Lim, Chang Rae Kim, Cho Rong Seo, Eunbaeck Kim, Gio Han, Jae-Hyug Woo, Jinhyun Kim, Kyoungjin Min, Min-A Lee, Min Ju Jeong, Min Kyoung Lee, Yong Su Lim, Young Sup Shim, Sung Bin Park, Chan Woong Kim, Dong Hoon Lee, Seung Eun Lee, Sung Eun Kim, Yoo Shin Choi, Sung Eun Rha, Eun Sun Jung, Gun Hyung Na, Han Joon Kim, Han Mo Yoo, Hye Kyung Chang, Joon Il Choi, Kyu Nam Park, Michael Yong Park, Moon Hyung Choi, Sang Hoon Oh, Seung Eun Jung, Sohee Lee, Soo Ah Im, Soo Hyun Kim, Soon Nam Oh, Tae Ho Hong, Won-Kyung Kang, Young Joon Lee, Young Hwan Lee, Dong Baek Kang, Hyun Soo Han, Jeong Woo Choi, Ki-Jung Yoon, Yong Hwang, Seong Sook Hong, Eui Sung Hwang, Heajin Chung, Hye Young Jang, Jiyoung Hwang, Jun Bum Park, Kyung Yul Hur, Yoon Mi Jeen, Young Joo Lee, Young Shin Cho, Han Jin Cho, Inyoung Choi, Jong Hak Park, Jooyeong Kim, Suk Keu Yeom, Sung Woo Moon, Young Sik Kim, Mi Sung Kim, Dong Hyuk Shin, Heon-Ju Kwon, Pil Cho Choi, Sang Kuk Han, Ji Young Woo, Gu Hyun Kang, Han Myun Kim, Hyun Young Choi, Ik Yang, Jae Ho Jang, Jeong Won Kim, Sang Nam Yoon, Won Hee Kim, Yong Soo Jang, Mi-Suk Park, In Cheol Park, Jae Gil Lee, Min Joung Kim, Yong Eun Chung, Jongmee Lee, Baek-Hui Kim, Chang Hee Lee, Jung-Youn Kim, Sanghee Kang, Sung-Hyuk Choi, Yang Shin Park, Seong Whi Cho, Chan Woo Park, Gi Bong Chae, Taek Guen Ohk, Yong-Hwan Jeon, Nurhee Hong, Dae Han Wi, Jun Hee Lee, Jung Nam Kwon, Seok Youn Lee, Weon-Cheol Han, Young Cheol Song, Mi Jeong Kim, Jung Hyeok Kwon, Seoung Kyu Beak, Sung Jin Kim, Woo Ik Choi, Yu Na Kang, Cheong-Il Shin, Dong Ho Lee, Gyeong Hoon Kang, Ijin Joo, Jeong Hee Yoon, Ji Won Park, Kyu Joo Park, Sang Do Shin, Seung-Bum Ryoo, Seung-Yong Jeong, Su Joa Ahn, Tae Han Kim, Won Chang, Yoon-Hye Kwon, Sang Soo Shin, Hee Joon Kim, Ho Goon Kim, Yong Soo Cho, Yoo Duk Choi, Bong Soo Kim, Chang Lim Hyun, Guk Myung Choi, In Ho Jeong, Kyeong Won Kang, Seung Hyoung Kim, Woo Jeong Kim, Young Joon Kang, Kwang Pyo Kim
BACKGROUND: CT radiation is arguably carcinogenic. Results from single-centre studies, mostly retrospective, have advocated lowering the CT radiation dose for the diagnosis of appendicitis. However, adoption of low-dose CT has been slow. We aimed to assess the effectiveness of low-dose CT compared with standard-dose CT in the diagnosis of appendicitis in adolescents and young adults. METHODS: We did this pragmatic, multicentre, randomised controlled non-inferiority trial at 20 South Korean teaching hospitals with little experience with low-dose CT...
September 11, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28902948/psychological-health-status-and-health-related-quality-of-life-in-adults-with-atopic-dermatitis-a-nationwide-cross-sectional-study-in-south-korea
#4
Sul Hee Lee, Si Hyung Lee, Sung Yul Lee, Bora Lee, Sang-Hoon Lee, Young Lip Park
Atopic dermatitis (AD) is a chronic inflammatory skin disorder. Patients with AD often experience psychological distress and poor health-related quality of life (HRQoL). The aim of this study was to investigate the association of several psychological health statuses and poor HRQoL in an adult population with AD in South Korea. A total of 38,741 adults who participated in the Korean National Health and Nutrition Examination Survey, a nationwide, population-based, cross-sectional health survey between 2008 and 2013 were included...
September 13, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28901689/prevascularization-of-3d-printed-bone-scaffolds-by-bioactive-hydrogels-and-cell-co-culture
#5
Mitchell A Kuss, Shaohua Wu, Ying Wang, Jason B Untrauer, Wenlong Li, Jung Yul Lim, Bin Duan
Vascularization is a fundamental prerequisite for large bone construct development and remains one of the main challenges of bone tissue engineering. Our current study presents the combination of 3D printing technique with a hydrogel-based prevascularization strategy to generate prevascularized bone constructs. Human adipose derived mesenchymal stem cells (ADMSC) and human umbilical vein endothelial cells (HUVEC) were encapsulated within our bioactive hydrogels, and the effects of culture conditions on in vitro vascularization were determined...
September 13, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28894469/ex-vivo-expansion-of-human-limbal-epithelial-cells-using-human-placenta-derived-and-umbilical-cord-derived-mesenchymal-stem-cells
#6
Sang Min Nam, Yong-Sun Maeng, Eung Kweon Kim, Kyoung Yul Seo, Helen Lew
Ex vivo culture of human limbal epithelial cells (LECs) is used to treat limbal stem cell (LSC) deficiency, a vision loss condition, and suitable culture systems using feeder cells or serum without animal elements have been developed. This study evaluated the use of human umbilical cord or placenta mesenchymal stem cells (C-MSCs or P-MSCs, resp.) as feeder cells in an animal/serum-free coculture system with human LECs. C-/P-MSCs stimulated LEC colony formation of the stem cell markers (p63, ABCG2) and secreted known LEC clonal growth factors (keratinocyte growth factor, β-nerve growth factor)...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28889038/control-of-plant-phosphate-homeostasis-by-inositol-pyrophosphates-and-the-spx-domain
#7
REVIEW
Ji-Yul Jung, Martina K Ried, Michael Hothorn, Yves Poirier
Proteins containing a SPX domain are involved in phosphate (Pi) homeostasis, including Pi transport and adaptation to Pi deficiency. The SPX domain harbors a basic surface binding Pi at low affinity and inositol pyrophosphates (PP-InsPs) at high affinity. Genetic and biochemical studies revealed that PP-InsPs serve as ligands for the SPX domain. Residues in the PHO1 SPX domain involved in PP-InsPs binding are critical for its Pi export activity, and the interaction between SPX proteins and the PHR1 transcription factor, which results in PHR1 inactivation, is promoted by PP-InsPs...
September 7, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28882698/prognostic-value-of-microrna-9-and-microrna-155-expression-in-triple-negative-breast-cancer
#8
Min Hye Jang, Hyun Jeong Kim, Jae Moon Gwak, Yul Ri Chung, So Yeon Park
MicroRNAs (miRNAs) are involved in regulation of epithelial-mesenchymal transition (EMT) during breast cancer progression. The purpose of this study was to analyze the clinicopathologic significance of expression of EMT-related miRNAs, miR-9 and miR-155, in triple-negative breast cancers (TNBCs). We analyzed relative expression levels of miR-9 and miR-155 in 190 surgically resected TNBC specimens using quantitative real-time polymerase chain reaction. Then we analyzed the relationship between these miRNA expression levels and EMT marker expression (vimentin, smooth muscle actin (SMA), osteonectin, N-cadherin, E-cadherin, CD146, and ZEB1) assessed by immunohistochemistry...
September 4, 2017: Human Pathology
https://www.readbyqxmd.com/read/28880337/effect-of-lowering-laser-energy-on-the-surface-roughness-of-human-corneal-lenticules-in-smile
#9
Yong Woo Ji, Minseo Kim, David Sung Yong Kang, Dan Z Reinstein, Timothy J Archer, Jin Young Choi, Eung Kweon Kim, Hyung Keun Lee, Kyoung Yul Seo, Tae-Im Kim
PURPOSE: To determine the effect of lowering femtosecond laser energy on the surface quality of the intrastromal interface during small incision lenticule extraction (SMILE). METHODS: Forty age- and diopter-matched female patients (40 eyes) with moderate myopia received SMILE with different energy levels (100 to 150 nJ) and fixed spot separation (4.5 μm). Five human corneal lenticules from each energy group were evaluated by atomic force microscopy and scanning electron microscopy (SEM)...
September 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28879670/assessments-for-bone-regeneration-using-the-polycaprolactone-slup-salt-leaching-using-powder-scaffold
#10
Yong Sang Cho, Myoung Wha Hong, Meiling Quan, So-Youn Kim, Se-Hwan Lee, Seung-Jae Lee, Young Yul Kim, Young-Sam Cho
Salt-leaching using powder (SLUP) scaffolds are novel salt-leaching scaffolds with well-interconnected pores that do not require an organic solvent or high pressure. In this study, in-vitro and in-vivo cell behaviors were assessed using a PCL (polycaprolactone) SLUP scaffold. Moreover, using PCL, conventional salt-leaching and 3D-plotted scaffolds were fabricated as control scaffolds. Morphology, mechanical property, water absorption, and in-vitro/in-vivo cell response assessments were performed to clarify the characteristics of the SLUP scaffold compared with control scaffolds...
September 6, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28879338/distribution-of-medical-status-and-medications-in-elderly-patients-treated-with-dental-implant-surgery-covered-by-national-healthcare-insurance-in-korea
#11
Kyungjin Lee, Chugeum Dam, Jisun Huh, Kyeong-Mee Park, Seo-Yul Kim, Wonse Park
BACKGROUND: The purpose of this study was to investigate the distribution of systemic diseases and medications in patients older than 65 years of age who visited the hospital for implant treatment, as well as to investigate basic information about surgical complications that may occur after insured implant treatment. METHODS: A total of 126 patients over 65 years of age were treated for implant surgery from October 1, 2013 to October 30, 2016. Electronic chart review was conducted to obtain medical records, which included sex, age, systemic diseases, medication(s) being taken, and control of the medications...
June 2017: J Dent Anesth Pain Med
https://www.readbyqxmd.com/read/28879329/creating-protective-appliances-for-preventing-dental-injury-during-endotracheal-intubation-using-intraoral-scanning-and-3d-printing-a-technical-note
#12
Jin-Hyung Cho, Wonse Park, Kyeong-Mee Park, Seo-Yul Kim, Kee-Deog Kim
Digital dentistry has influenced many dental procedures, such as three-dimensional (3D) diagnosis and treatment planning, surgical splints, and prosthetic treatments. Patient-specific protective appliances (PSPAs) prevent dental injury during endotracheal intubation. However, the required laboratory work takes time, and there is the possibility of tooth extraction while obtaining the dental impression. In this technical report, we utilized new digital technology for creating PSPAs, using direct intraoral scanners and 3D printers for dental cast fabrication...
March 2017: J Dent Anesth Pain Med
https://www.readbyqxmd.com/read/28871264/neuroinflammation-bone-marrow-stem-cells-and-chronic-pain
#13
REVIEW
Yul Huh, Ru-Rong Ji, Gang Chen
Current treatments for chronic pain, such as inflammatory pain, neuropathic pain, and cancer pain are insufficient and cause severe side effects. Mounting evidence suggests that neuroinflammation in the peripheral and central nervous system (PNS and CNS) plays a pivotal role in the genesis and maintenance of chronic pain. Characteristic features of neuroinflammation in chronic pain conditions include infiltration of immune cells into the PNS [e.g., the sciatic nerve and dorsal root ganglion (DRG)], activation of glial cells such as microglia and astrocytes in the CNS (spinal cord and brain), and production and secretion of pro-inflammatory cytokines and chemokines [TNF, interleukin (IL)-1β, IL-6, CCL2, and CXCL1]...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28861392/the-effect-of-fluoride-containing-oral-rinses-on-the-corrosion-resistance-of-titanium-alloy-ti-6al-4v
#14
Gui-Yue Huang, Heng Bo Jiang, Jung-Yul Cha, Kwang-Mahn Kim, Chung-Ju Hwang
OBJECTIVE: The purpose of this study was to examine the effect of commercially available fluoride-containing oral rinses on the corrosion behavior of titanium alloys, which are the main components of orthodontic miniscrews. METHODS: Four commercially available oral rinses (solution A, pH 4.46/260 ppm fluoride; solution B, pH 4.41/178 ppm fluoride; solution C, pH 6.30/117 ppm fluoride; and solution D, pH 4.17/3.92 ppm fluoride) were tested on titanium alloy (Ti-6Al-4V) circular plates, and saline was used as the control...
September 2017: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/28857999/transnasal-endoscopic-resection-of-a-pleomorphic-adenoma-originate-from-nasal-floor
#15
Yesun Cho, Yul Gyun Kim, Eunhye Shin, Boo-Young Kim
A 81-year-old female presented to our hospital frequent epistaxis. Nasal endoscopy showed a mass obstructing nasal cavity completely and occupying middle meatus. Magnetic resonance imaging was performed, an about 4.8 × 4 × 4.2 cm sized heterogeneous T2 high signal intensity and T1 enhancing mass mainly involving right nasal cavity with invasion of right hard palate with bony destruction. Therefore, the authors planned to do endoscopic mass excision, under general anesthesia for diagnosis and treatment...
August 28, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28853165/changes-in-psychological-health-subjective-food-intake-ability-and-oral-health-related-quality-of-life-during-orthodontic-treatment
#16
Sung-Hwan Choi, Jung-Yul Cha, Kee-Joon Lee, Hyung-Seog Yu, Chung-Ju Hwang
BACKGROUND: Assessing changes in patient's psychological health and oral health-related quality of life (OHRQoL) over time during orthodontic treatment may help clinicians to treat patients more carefully. OBJECTIVES: To evaluate changes in mental health, self-reported masticatory ability, and OHRQoL during orthodontic treatment in adults. METHODS: This prospective study included 66 adults (30 men, 36 women; mean age, 24.2 ± 5.2 years). Each patient completed the Korean versions of the State-Trait Anxiety Inventory, Zung Self-Rating Depression Scale, Rosenberg self-esteem scale, key subjective food intake ability (KFIA) test for five key foods, and Oral Health Impact Profile-14 (OHIP-14K) at baseline (T0), 12 months after treatment initiation (T1), and debonding (T2)...
August 29, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28838705/comparison-of-outcomes-between-partially-healed-and-acute-metaphyseally-malaligned-distal-radial-fracture-treated-by-palmar-locking-plate-fixation
#17
Joo-Yul Bae, Jun O Yoon, Shin Woo Choi, Jae Kwang Kim
BACKGROUND: The purpose of this study was to determine whether a partially healed (surgical delay of 2-6 weeks) metaphyseally malaligned distal radius fracture (DRF) treated using the extended palmar approach with palmar locking plate fixation has poorer clinical or radiological outcomes than those of acute (surgical delay of ≤2 weeks) metaphyseally unstable DRF treated by palmar locking plate fixation. METHODS: We identified 24 patients (Group A) who were treated with palmar locking plate for a partially healed (surgical delay of 2-6 weeks) metaphyseally malaligned DRF...
August 21, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28816370/does-depression-decrease-the-moderating-effect-of-self-efficacy-in-the-relationship-between-illness-perception-and-fear-of-progression-in-breast-cancer
#18
Eun-Jung Shim, Jong Won Lee, Yul Ha Min
OBJECTIVE: Fear of progression (FOP) is a prevalent concern among breast cancer patients that affect their adjustment to disease. This study examined whether self-efficacy moderates the effect of illness perception (IP) on FOP and whether the moderating effect of self-efficacy depends on the level of depressive symptoms. METHODS: A cross-sectional survey including brief illness perception questionnaire (BIPQ), FOP short form, general self-efficacy scale, and the center for epidemiologic studies depression scale were administered to 245 patients with breast cancer in Korea...
August 17, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28772353/withdrawn-uterine-arteriovenous-malformation-accompanied-with-a-uterine-stromomyoma
#19
Yul Ri Chung, Dohee Kwon, Sehui Kim, Hee Young Na, Nayoung Han, Hyo Jin Kim, Min A Kim, In Ae Park
Ahead of Print article withdrawn by publisher.
August 4, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28762959/mechanical-properties-and-cell-culture-characteristics-of-a-polycaprolactone-kagome-structure-scaffold-fabricated-by-a-precision-extruding-deposition-system
#20
Se-Hwan Lee, Yong Sang Cho, Myoung Wha Hong, Bu-Kyu Lee, Yongdoo Park, Sang-Hyug Park, Young Yul Kim, Young-Sam Cho
To enhance the mechanical properties of three-dimensional (3D) scaffolds used for bone regeneration in tissue engineering, many researchers have studied their structure and chemistry. In the structural engineering field, the kagome structure has been known to have an excellent relative strength. In this study, to enhance the mechanical properties of a synthetic polymer scaffold used for tissue engineering, we applied the 3D kagome structure to a porous scaffold for bone regeneration. Prior to fabricating the biocompatible-polymer scaffold, the ideal kagome structure, which was manufactured by a 3D printer of the digital light processing type, was compared with a grid-structure, which was used as the control group, using a compressive experiment...
September 13, 2017: Biomedical Materials
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