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https://www.readbyqxmd.com/read/29166762/a-portable-high-intensity-focused-ultrasound-system-for-the-pancreas-with-3d-electronic-steering-a-preclinical-study-in-a-swine-model
#1
Won Chang, Jae Young Lee, Jae Hwan Lee, Jae Seok Bae, Yeon Jin Cho, Kook Jin Kang, Keonho Son, Yul Ri Chung, Kyoung Bun Lee, Joon Koo Han
Purpose: The aim of this animal study was to evaluate the safety and feasibility of a portable, ultrasonography-guided, high-intensity focused ultrasound (USg-HIFU) system to treat the pancreas. Methods: Eight swine were included. Using a portable HIFU device (ALPIUS 900, Alpinion Medical Systems), ablations were performed on the pancreas in vivo. Different acoustic intensities were applied (1.7 kW/cm2 or 1.5 kW/cm2 , n=2 [group A for a pilot study]; 1.5 kW/ cm2 , n=3 [group B]; and 1...
October 13, 2017: Ultrasonography
https://www.readbyqxmd.com/read/29165109/attitude-and-practice-of-physical-activity-and-social-problem-solving-ability-among-university-students
#2
Toshimasa Sone, Yousuke Kawachi, Chihiro Abe, Yuki Otomo, Yul-Wan Sung, Seiji Ogawa
BACKGROUND: Effective social problem-solving abilities can contribute to decreased risk of poor mental health. In addition, physical activity has a favorable effect on mental health. These previous studies suggest that physical activity and social problem-solving ability can interact by helping to sustain mental health. The present study aimed to determine the association between attitude and practice of physical activity and social problem-solving ability among university students. METHODS: Information on physical activity and social problem-solving was collected using a self-administered questionnaire...
April 4, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29164831/udenafil-a-phosphodiesterase-5-inhibitor-reduces-body-weight-in-high-fat-fed-mice
#3
Seong Yul Ryu, Yoon Jung Choi, So Young Park, Jong Yeon Kim, Yong Dae Kim, Yong Woon Kim
PURPOSE: High-fat (HF) feeding induces hypothalamic leptin resistance via the activation of toll-like receptor 4 (TLR4). TLR4 deficiency confers resistance to diet-induced obesity. Udenafil, an anti-impotence drug, inhibits TLR4 in airway epithelial cells in vitro. In this study, we evaluated whether udenafil suppressed the hypothalamic expression of TLR4 and reduced body weight. MATERIALS AND METHODS: The hypothalamic expression of TLR4, phosphodiesterase 5 (PDE5), nuclear factor-κB (NF-κB), and myeloid differentiation primary response gene 88 (Myd88) was analyzed by real-time polymerase chain reaction after treating mice for 2 days with udenafil (0, 12, 120, or 600 μg/d)...
November 16, 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/29161707/a-novel-animal-model-simulating-the-beginning-of-combat-exposure
#4
Dongsoo Kim, Chang Yul Kim, Hyojin Koo, Yong Heo, Kicheol Cheon
OBJECTIVE: Predator stress, social defeat stress, and fear conditioning animal models have been applied to investigate combat-related posttraumatic stress disorder (PTSD). However, no animal model psychopharmacological studies have investigated prevention of somatization of increased mental stress and fatigue at the beginning of combat exposure. This study utilized a novel animal model simulating the beginning of combat exposure that aided specification of a set of biomarkers. METHODS: Psychological stress was induced by both inescapable electric foot shock and noise stimuli...
November 22, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29152973/epidermal-microfluidic-electrochemical-detection-system-enhanced-sweat-sampling-and-metabolite-detection
#5
Aida Martin, Jayoung Kim, Jonas F Kurniawan, Juliane R Sempionatto, Jose R Moreto, Guangda Tang, Alan C Campbell, Andrew Shin, Min Yul Lee, Xiaofeng Liu, Joseph Wang
Despite tremendous recent efforts, non-invasive sweat monitoring is still far from delivering its early analytical promise. Here, we describe a flexible epidermal microfluidic detection platform fabricated through hybridization of lithographic and screen-printed technologies for efficient sweat sampling and continuous real-time electrochemical monitoring of sweat glucose and lactate levels. This soft, skin-mounted device judiciously merges lab-on-a-chip and electrochemical detection technologies, integrated with a miniaturized flexible electronic board for real-time wireless data transmission to a smart device...
November 20, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29135701/verification-of-the-optimal-chest-compression-depth-for-children-in-the-2015-american-heart-association-guidelines-computed-tomography-study
#6
Yong Hwan Kim, Jun Ho Lee, Kwang Won Cho, Dong Woo Lee, Mun Ju Kang, Kyoung Yul Lee, Joung Hun Byun, Young Hwan Lee, Seong Youn Hwang, Na Kyoung Lee
OBJECTIVE: The 2015 American Heart Association guidelines recommended pediatric rescue chest compressions of at least one-third the anteroposterior diameter of the chest, which equates to approximately 5 cm. This study evaluated the appropriateness of these two types by comparing their safeties in chest compression depth simulated by CT. DESIGN: Retrospective study with data analysis conducted from January 2005 to June 2015 SETTING:: Regional emergency center in South Korea...
November 11, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29132849/treatment-of-vismodegib-associated-muscle-cramps-with-cyclobenzaprine-a-retrospective-review
#7
Yul W Yang, James B Macdonald, Steven A Nelson, Aleksandar Sekulic
No abstract text is available yet for this article.
December 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29131859/development-and-validation-of-an-immunoperoxidase-antigen-detection-test-for-improved-diagnosis-of-rabies-in-indonesia
#8
Ibnu Rahmadane, Andrea F Certoma, Grantley R Peck, Yul Fitria, Jean Payne, Axel Colling, Brian J Shiell, Gary Beddome, Susanne Wilson, Meng Yu, Chris Morrissy, Wojtek P Michalski, John Bingham, Ian A Gardner, John D Allen
Rabies continues to pose a significant threat to human and animal health in regions of Indonesia. Indonesia has an extensive network of veterinary diagnostic laboratories and the 8 National laboratories are equipped to undertake diagnostic testing for rabies using the commercially-procured direct fluorescent antibody test (FAT), which is considered the reference (gold standard) test. However, many of the Indonesian Provincial diagnostic laboratories do not have a fluorescence microscope required to undertake the FAT...
November 13, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29131663/factors-associated-with-long-term-vertical-skeletal-changes-induced-by-facemask-therapy-in-patients-with-class-iii-malocclusion
#9
Hee-Jong Kwak, Hae-Jin Park, Yoon-Ji Kim, Dong-Yul Lee
OBJECTIVES: This study investigated the long-term vertical skeletal changes induced by facemask therapy in patients with Class III malocclusion and different vertical skeletal patterns. MATERIALS AND METHODS: A total of 54 patients (20 boys and 34 girls; mean age, 7.7 ± 2.0 years) with Class III malocclusion who were successfully treated with facemask therapy were included in this study. Vertical skeletal changes (overbite depth indicator, angle between the Sella-Nasion (SN) plane and Gonion-Gnathion (GoGn) line, angle between the Frankfort horizontal (FH) plane and mandibular plane, gonial angle, and angle between the SN plane and palatal plane) were measured on lateral cephalograms from before treatment (T0) to after facemask therapy (T1) and from T0 to after retention (T2)...
November 13, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/29129046/acebutolol-a-cardioselective-beta-blocker-promotes-glucose-uptake-in-diabetic-model-cells-by-inhibiting-jnk-jip1-interaction
#10
Yi Li, Nan-Young Jung, Jae Cheal Yoo, Yul Kim, Gwan-Su Yi
The phosphorylation of JNK is known to induce insulin resistance in insulin target tissues. The inhibition of JNK-JIP1 interaction, which interferes JNK phosphorylation, becomes a potential target for drug development of type 2 diabetes. To discover the inhibitors of JNK-JIP1 interaction, we screened out 30 candidates from 4320 compound library with In Cell Interaction Trap method. The candidates were further confirmed and narrowed down to five compounds using the FRET method in a model cell. Among those five compounds, Acebutolol showed notable inhibition of JNK phosphorylation and elevation of glucose uptake in diabetic models of adipocyte and liver cell...
November 13, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29122668/estimation-of-physiological-sources-of-nonlinearity-in-blood-oxygenation-level-dependent-contrast-signals
#11
Daehun Kang, Yul-Wan Sung, Satoshi Shioiri
Blood oxygenation level-dependent (BOLD) contrast appears through a variation in the transverse relaxation rate of magnetic resonance signals induced by neurovascular coupling and is known to have nonlinear characteristics along echo time (TE) due to the intra-vasculature. However, the physiological causes of this nonlinearity are unclear. We attempted to estimate the physiological information related to the nonlinearity of BOLD signals by using a two-compartment model. For this purpose, we used a multi-echo gradient-echo echo-planar imaging sequence and developed a computational method to estimate the physiological information from the TE-dependent BOLD signals...
November 6, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29105332/electrochemical-synthesis-of-ammonia-from-water-and-nitrogen-a-lithium-mediated-approach-using-lithium-ion-conducting-glass-ceramic
#12
Kwiyong Kim, Seung Jong Lee, Dong-Yeon Kim, Chung-Yul Yoo, Jang Wook Choi, Jong-Nam Kim, Youngmin Woo, Hyung Chul Yoon, Jong-In Han
Lithium-mediated reduction of dinitrogen is a promising way to evade electron-stealing hydrogen evolution, a critical challenge which limits faradaic efficiency (FE) and thus hinders the success of traditional protic solvent-based ammonia electro-synthesis. In this study, we propose a viable illustration to realize the lithium-mediated pathway using lithium-ion conducting glass ceramic, which can be divided into three successive steps: (i) lithium deposition, (ii) nitridation, and (iii) ammonia formation. Ammonia was successfully synthesized from molecular nitrogen and water, yielding a maximum FE of 52...
November 3, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29095872/multi-categorical-deep-learning-neural-network-to-classify-retinal-images-a-pilot-study-employing-small-database
#13
Joon Yul Choi, Tae Keun Yoo, Jeong Gi Seo, Jiyong Kwak, Terry Taewoong Um, Tyler Hyungtaek Rim
Deep learning emerges as a powerful tool for analyzing medical images. Retinal disease detection by using computer-aided diagnosis from fundus image has emerged as a new method. We applied deep learning convolutional neural network by using MatConvNet for an automated detection of multiple retinal diseases with fundus photographs involved in STructured Analysis of the REtina (STARE) database. Dataset was built by expanding data on 10 categories, including normal retina and nine retinal diseases. The optimal outcomes were acquired by using a random forest transfer learning based on VGG-19 architecture...
2017: PloS One
https://www.readbyqxmd.com/read/29075575/neural-correlates-of-korean-proverb-processing-a-functional-magnetic-resonance-imaging-study
#14
You Gyoung Yi, Dae Yul Kim, Woo Hyun Shim, Joo Young Oh, Sung Hyun Kim, Ho Sung Kim
INTRODUCTION: The Korean language is based on a syntactic system that is different from other languages. This study investigated the processing area of the Korean proverb in comparison with the literal sentence using functional magnetic resonance imaging. In addition, the effect of opacity and transparency of proverbs on the activation pattern, when familiarity is set to the same condition, was also examined. METHODS: The experimental stimuli included 36 proverbs and 18 literal sentences...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29072721/oxygen-plasma-treatment-of-hkust-1-for-porosity-retention-upon-exposure-to-moisture
#15
Jaeyeon Bae, Jin-Woo Jung, Hyo Yul Park, Chang-Hee Cho, Jinhee Park
Despite their remarkable properties, metal-organic frameworks (MOFs) present vulnerable structures that are sensitive to moisture; therefore, their application to real field situations is challenging. Herein, an O2 plasma technique was introduced as a new method for the activation and protection of porosity in HKUST-1. In an unprecedented manner, O2 plasma-treated HKUST-1 retains its porosity after a long exposure to moisture as compared to pristine HKUST-1. Porosity retention was examined by N2 adsorption/desorption measurements of non-activated HKUST-1 after exposure to moisture...
November 7, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29065906/biological-function-integrated-prediction-of-severe-radiographic-progression-in-rheumatoid-arthritis-a-nested-case-control-study
#16
Young Bin Joo, Yul Kim, Youngho Park, Kwangwoo Kim, Jeong Ah Ryu, Seunghun Lee, So-Young Bang, Hye-Soon Lee, Gwan-Su Yi, Sang-Cheol Bae
BACKGROUND: Radiographic progression is reported to be highly heritable in rheumatoid arthritis (RA). However, previous study using genetic loci showed an insufficient accuracy of prediction for radiographic progression. The aim of this study is to identify a biologically relevant prediction model of radiographic progression in patients with RA using a genome-wide association study (GWAS) combined with bioinformatics analysis. METHODS: We obtained genome-wide single nucleotide polymorphism (SNP) data for 374 Korean patients with RA using Illumina HumanOmni2...
October 25, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29059096/dermoscopic-findings-of-irritant-poral-reactions-to-cobalt-during-patch-testing
#17
Yul W Yang, Collin M Costello, Aaron R Mangold
No abstract text is available yet for this article.
November 2017: Dermatitis
https://www.readbyqxmd.com/read/29057873/macrophage-vldlr-mediates-obesity-induced-insulin-resistance-with-adipose-tissue-inflammation
#18
Kyung Cheul Shin, Injae Hwang, Sung Sik Choe, Jeu Park, Yul Ji, Jong In Kim, Gha Young Lee, Sung Hee Choi, Jianhong Ching, Jean-Paul Kovalik, Jae Bum Kim
Obesity is closely associated with increased adipose tissue macrophages (ATMs), which contribute to systemic insulin resistance and altered lipid metabolism by creating a pro-inflammatory environment. Very low-density lipoprotein receptor (VLDLR) is involved in lipoprotein uptake and storage. However, whether lipid uptake via VLDLR in macrophages affects obesity-induced inflammatory responses and insulin resistance is not well understood. Here we show that elevated VLDLR expression in ATMs promotes adipose tissue inflammation and glucose intolerance in obese mice...
October 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/29056940/complete-chloroplast-genome-sequences-and-comparative-analysis-of-chenopodium-quinoa-and-c-album
#19
Su-Young Hong, Kyeong-Sik Cheon, Ki-Oug Yoo, Hyun-Oh Lee, Kwang-Soo Cho, Jong-Taek Suh, Su-Jeong Kim, Jeong-Hwan Nam, Hwang-Bae Sohn, Yul-Ho Kim
The Chenopodium genus comprises ~150 species, including Chenopodium quinoa and Chenopodium album, two important crops with high nutritional value. To elucidate the phylogenetic relationship between the two species, the complete chloroplast (cp) genomes of these species were obtained by next generation sequencing. We performed comparative analysis of the sequences and, using InDel markers, inferred phylogeny and genetic diversity of the Chenopodium genus. The cp genome is 152,099 bp (C. quinoa) and 152,167 bp (C...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29037010/effects-of-triflusal-and-clopidogrel-on-the-secondary-prevention-of-stroke-based-on-cytochrome-p450-2c19-genotyping
#20
Sang Won Han, Yong-Jae Kim, Seong Hwan Ahn, Woo-Keun Seo, Sungwook Yu, Seung-Hun Oh, Hyo Suk Nam, Hye-Yeon Choi, Sung Sang Yoon, Seo Hyun Kim, Jong Yun Lee, Jun Hong Lee, Yang-Ha Hwang, Kee Ook Lee, Yo Han Jung, Jun Lee, Sung-Il Sohn, Youn Nam Kim, Kyung-A Lee, Cheryl D Bushnell, Kyung-Yul Lee
BACKGROUND AND PURPOSE: To compare the efficacy and safety of antiplatelet agents for the secondary prevention of ischemic stroke based on cytochrome P450 2C19 (CYP2C19) polymorphisms. METHODS: This study was a prospective, multicenter, randomized, parallel-group, open-label, blind genotype trial. First time non-cardiogenic ischemic stroke patients were enrolled and screened within 30 days. Participants were randomized to receive either triflusal or clopidogrel for secondary stroke prevention...
September 2017: Journal of Stroke
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