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https://www.readbyqxmd.com/read/28411245/characteristics-of-earlier-versus-delayed-presentation-of-very-late-drug-eluting-stent-thrombosis-an-optical-coherence-tomographic-study
#1
Seung-Yul Lee, Jung-Min Ahn, Gary S Mintz, Seung-Ho Hur, So-Yeon Choi, Sang-Wook Kim, Jin Man Cho, Soon Jun Hong, Jin Won Kim, Young Joon Hong, Sang-Gon Lee, Dong-Ho Shin, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Yangsoo Jang, Seung-Jung Park, Myeong-Ki Hong
BACKGROUND: The pathophysiology underlying very late drug-eluting stent (DES) thrombosis is not sufficiently understood. Using optical coherence tomography, we investigated characteristics of very late stent thrombosis (VLST) according to different onset times. METHODS AND RESULTS: A total of 98 patients from 10 South Korean hospitals who underwent optical coherence tomography for evaluation of very late DES thrombosis were retrospectively included in analyses. VLST occurred at a median of 55...
April 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28403194/calculations-of-actual-corneal-astigmatism-using-total-corneal-refractive-power-before-and-after-myopic-keratorefractive-surgery
#2
Kyoung Yul Seo, Hun Yang, Wook Kyum Kim, Sang Min Nam
PURPOSE: To calculate actual corneal astigmatism using the total corneal refractive astigmatism for the 4-mm apex zone of the Pentacam (TCRP4astig) and keratometric astigmatism (Kastig) before and after photorefractive keratectomy or laser in situ keratomileusis. METHODS: Uncomplicated 56 eyes after more than 6 months from the surgery were recruited by chart review. Various corneal astigmatisms were measured using the Pentacam and autokeratometer before and after surgery...
2017: PloS One
https://www.readbyqxmd.com/read/28382274/circulating-aneuploid-cells-detected-in-the-blood-of-patients-with-infectious-lung-diseases
#3
Hongsun Kim, Jong Ho Cho, Chung-Hee Sonn, Jae-Won Kim, Yul Choi, Jinseon Lee, Jhingook Kim
The identification of circulating tumor cells (CTCs) is clinically important for diagnosing cancer. We have previously developed a size-based filtration platform followed by epithelial cell adhesion molecule immunofluorescence staining for detecting CTCs. To characterize CTCs independently of cell surface protein expression, we incorporated a chromosomal fluorescence in situ hybridization (FISH) assay to detect abnormal copy numbers of chromosomes in cells collected from peripheral blood samples by the size-based filtration platform...
April 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28382093/microrna-222-expression-as-a-predictive-marker-for-tumor-progression-in-hormone-receptor-positive-breast-cancer
#4
Song-Hee Han, Hyun Jeong Kim, Jae Moon Gwak, Mimi Kim, Yul Ri Chung, So Yeon Park
PURPOSE: The microRNA-221/222 (miR-221/222) gene cluster has been reported to be associated with the promotion of epithelial-mesenchymal transition (EMT), downregulation of estrogen receptor-α, and tamoxifen resistance in breast cancer. We studied the expression of miR-222 in human breast cancer samples to analyze its relationship with clinicopathologic features of the tumor, including estrogen receptor status, expression of EMT markers, and clinical outcomes. METHODS: Quantitative real-time polymerase chain reaction was performed to detect the expression of miR-222 in 197 invasive breast cancers...
March 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28378159/longitudinal-patterns-and-associated-factors-of-postdiagnosis-weight-changes-in-korean-breast-cancer-survivors-with-normal-body-mass-index
#5
Yul Ha Min, Jong Won Lee, Il Yong Chung, Sei Hyun Ahn
PURPOSE: This study aimed to describe longitudinal patterns of weight changes from diagnosis to within 5 years after diagnosis and investigate factors associated with short- and long-term weight changes among Korean breast cancer survivors with initially normal body mass index (BMI). METHODS: Body weights at diagnosis for 1546 breast cancer survivors were compared with those at 12, 24, 36, 48, and 60 months after diagnosis. Absolute weight change (kg) and relative weight changes (%) were analyzed...
April 4, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28372344/mammary-carcinoma-arising-in-microglandular-adenosis-a-report-of-five-cases
#6
Mimi Kim, Milim Kim, Yul Ri Chung, So Yeon Park
Mammary carcinoma arising in microglandular adenosis (MGA) is extremely rare, and MGA is regarded as a non-obligate precursor of triple-negative breast cancer. We report five cases of carcinoma arising in MGA of the breast. All cases showed a spectrum of proliferative lesions ranging from MGA to atypical MGA, ductal carcinoma in situ or invasive carcinoma. Immunohistochemically, all cases were triple-negative and expression of S-100 protein gradually decreased as the lesions progressed from MGA to atypical MGA and carcinoma...
April 4, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28366363/comparison-of-clinical-outcomes-between-wavefront-optimized-versus-corneal-wavefront-guided-transepithelial-photorefractive-keratectomy-for-myopic-astigmatism
#7
Ikhyun Jun, David Sung Yong Kang, Jerry Tan, Jin Young Choi, Woon Heo, Joo Young Kim, Min Goo Lee, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
PURPOSE: To evaluate and compare the clinical outcomes, including visual acuity, refractive errors, and aberrations, between aberration-free transepithelial photorefractive keratectomy (PRK) and corneal wavefront-guided transepithelial PRK in eyes with myopic astigmatism. SETTING: Yonsei University College of Medicine and Eyereum Eye Clinic, Seoul, South Korea. DESIGN: Retrospective comparative case series. METHODS: Patients with myopic astigmatism were treated with aberration-free transepithelial PRK or corneal wavefront-guided transepithelial PRK using a 1050 Hz high-repetition excimer laser...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28359760/effect-of-p62-sqstm1-polyubiquitination-on-its-autophagic-adaptor-function-and-cellular-survival-under-oxidative-stress-induced-by-arsenite
#8
Hyuna Lee, Mi-Nam Kim, Kwon-Yul Ryu
Oxidative stress induced by arsenite [As(III)] affects protein folding and results in increased levels of misfolded proteins or protein aggregates. Accumulation of misfolded protein aggregates may act as a cue signal for the oligomerization of the autophagic adaptor protein p62, which facilitates recognition of misfolded protein aggregates that are polyubiquitinated with K63 linkages. However, as the autophagic flux is impaired under exposure to As(III), p62 oligomers cannot be cleared by autophagy and accumulate as aggregates with Keap1...
March 28, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28350465/3-5-diarylimidazo-1-2-a-pyridines-as-color-tunable-fluorophores
#9
Ju Young Lee, Jae Yul Shim, Hong Ki Kim, Donguk Ko, Mu-Hyun Baik, Eun Jeong Yoo
A new protocol for the synthesis of color-tunable fluorescent 3,5-diarylimidazo[1,2-a]pyridines has been achieved via palladium-catalyzed C-H amination of pyridinium zwitterions. Based on experimental results and computational analysis, we extracted a high correlation of photophysical properties with the theoretical concept and predicted emission wavelengths of 3,5-diarylimidazo[1,2-a]pyridines. The emission wavelengths of imidazo[1,2-a]pyridines increase as a function of the electron-withdrawing nature of the substituent on the C5-aryl group of imidazo[1,2-a]pyridine as a result of inductive effects on the LUMO levels...
April 7, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28346495/the-incidence-and-prevalence-of-pterygium-in-south-korea-a-10-year-population-based-korean-cohort-study
#10
Tyler Hyungtaek Rim, Min Jae Kang, Moonjung Choi, Kyoung Yul Seo, Sung Soo Kim
Although numerous population-based studies have reported the prevalences and risk factors for pterygium, information regarding the incidence of pterygium is scarce. This population-based cohort study aimed to evaluate the South Korean incidence and prevalence of pterygium. We retrospectively obtained data from a nationally representative sample of 1,116,364 South Koreans in the Korea National Health Insurance Service National Sample Cohort (NHIS-NSC). The associated sociodemographic factors were evaluated using multivariable Cox regression analysis, and the hazard ratios and confidence intervals were calculated...
2017: PloS One
https://www.readbyqxmd.com/read/28345313/acute-hyperglycemia-associated-with-anti-cancer-medication
#11
REVIEW
Yul Hwangbo, Eun Kyung Lee
Hyperglycemia during chemotherapy occurs in approximately 10% to 30% of patients. Glucocorticoids and L-asparaginase are well known to cause acute hyperglycemia during chemotherapy. Long-term hyperglycemia is also frequently observed, especially in patients with hematologic malignancies treated with L-asparaginase-based regimens and total body irradiation. Glucocorticoid-induced hyperglycemia often develops because of increased insulin resistance, diminished insulin secretion, and exaggerated hepatic glucose output...
March 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28338146/a-gold-nanoparticle-mediated-rapid-in-vitro-assay-of-anti-aggregation-reagents-for-amyloid-%C3%AE-and-its-validation
#12
Hye Young Kim, Donghee Lee, Kwon-Yul Ryu, Inhee Choi
Herein, we report a rapid in vitro assay of amyloid β anti-aggregation reagents using gold nanoparticles as nucleation cores and optical reporters. Based on the colorimetric responses observed with the naked eye, effective anti-aggregation reagents were rapidly (<15 min) distinguished. For these reagents, conventional methods showed fewer amyloid β aggregates and an increased viability of neuroblastoma cells after treatment. We envision that our proposed method will facilitate the discovery of efficient drug components for the treatment of Alzheimer's disease...
March 24, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28337417/skeletal-and-dentoalveolar-changes-after-miniscrew-assisted-rapid-palatal-expansion-in-young-adults-a-cone-beam-computed-tomography-study
#13
Jung Jin Park, Young-Chel Park, Kee-Joon Lee, Jung-Yul Cha, Ji Hyun Tahk, Yoon Jeong Choi
OBJECTIVE: The aim of this study was to evaluate the skeletal and dentoalveolar changes after miniscrew-assisted rapid palatal expansion (MARPE) in young adults by cone-beam computed tomography (CBCT). METHODS: This retrospective study included 14 patients (mean age, 20.1 years; range, 16-26 years) with maxillary transverse deficiency treated with MARPE. Skeletal and dentoalveolar changes were evaluated using CBCT images acquired before and after expansion. Statistical analyses were performed using paired t-test or Wilcoxon signed-rank test according to normality of the data...
March 2017: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/28325888/factors-associated-with-clinical-outcomes-in-patients-with-primary-intraventricular-hemorrhage
#14
Sang-Hoon Lee, Kyung-Jae Park, Dong-Hyuk Park, Shin-Hyuk Kang, Jung-Yul Park, Yong-Gu Chung
BACKGROUND Primary intraventricular hemorrhage (PIVH) is an uncommon type of intracerebral hemorrhage. Owing to its rarity, the clinical and radiological factors affecting outcomes in patients with PIVH have not been widely studied. MATERIAL AND METHODS We retrospectively reviewed 112 patients (mean age 53 years) treated for PIVH at our institution from January 2004 to December 2014. Clinical and radiological parameters were analyzed 3 months after initial presentation to identify factors associated with clinical outcomes, as assessed by the Glasgow Outcome Scale (favorable ≥4, unfavorable <4)...
March 22, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28322349/an-aqueous-electrolyte-of-the-widest-potential-window-and-its-superior-capability-for-capacitors
#15
Hiroshi Tomiyasu, Hirokazu Shikata, Koichiro Takao, Noriko Asanuma, Seiichi Taruta, Yoon-Yul Park
A saturated aqueous solution of sodium perchlorate (SSPAS) was found to be electrochemically superior, because the potential window is remarkably wide to be approximately 3.2 V in terms of a cyclic voltammetry. Such a wide potential window has never been reported in any aqueous solutions, and this finding would be of historical significance for aqueous electrolyte to overcome its weak point that the potential window is narrow. In proof of this fact, the capability of SSPAS was examined for the electrolyte of capacitors...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28303807/efficacy-and-safety-of-newly-developed-cross-linked-dextran-gel-injection-for-glans-penis-augmentation-with-a-novel-technique
#16
Dae Yul Yang, Kyungtae Ko, Seong Ho Lee, Du Geon Moon, Jong Wook Kim, Won Ki Lee
There is no safe and effective standard method for glans penis augmentation. Furthermore, there has been scant research on glans penis augmentation due to a poor understanding of glans anatomy, technical difficulty, and a lack of suitable substances for augmentation. Cross-linked dextran gel is a newly developed filler for soft-tissue augmentation. We evaluated the efficacy and safety of using a novel technique to inject cross-linked dextran gel for glans penis augmentation during a 24-week follow-up study...
March 10, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28295626/mechanical-meibomian-gland-squeezing-combined-with-eyelid-scrubs-and-warm-compresses-for-the-treatment-of-meibomian-gland-dysfunction
#17
Hun Lee, Minseo Kim, Si Yoon Park, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
BACKGROUND: The aim was to investigate the efficacy of mechanical meibomian gland squeezing combined with eyelid scrubs and warm compresses in participants with moderate and severe meibomian gland dysfunction (MGD). METHODS: In this prospective, uncontrolled, open label, intervention study, 32 eyes of 32 participants with moderate and severe MGD were treated with mechanical squeezing of meibomian glands in combination with eyelid scrubs and warm compresses. We evaluated tear film break-up time (TBUT), corneal and conjunctival fluorescein staining scores, biomicroscopic examination of lid margins and meibomian glands, Ocular Surface Disease Index (OSDI) questionnaire and tear film lipid layer thickness determined via an interferometer before initiating treatment and after one month of treatment...
March 12, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28289646/effectiveness-of-ear-splint-therapy-for-ear-deformities
#18
Ji Eun Woo, Yul-Hyun Park, Eun Ji Park, Kyu Yong Park, Sun Hee Kim, Shin-Young Yim
OBJECTIVE: To present our experience with ear splint therapy for babies with ear deformities, and thereby demonstrate that this therapy is an effective and safe intervention without significant complications. METHODS: This was a retrospective study of 54 babies (35 boys and 19 girls; 80 ears; age ≤3 months) with ear deformities who had received ear splint therapy at the Center for Torticollis, Department of Physical Medicine and Rehabilitation, Ajou University Hospital between December 2014 and February 2016...
February 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28285139/regulation-of-rest-levels-overcomes-dysregulation-of-neural-stem-cell-differentiation-caused-by-disruption-of-polyubiquitin-gene-ubb
#19
Minji Kim, Kwon-Yul Ryu
Reduced levels of cellular ubiquitin (Ub) caused by disruption of the polyubiquitin gene Ubb lead to dysregulated differentiation of neural stem/progenitor cells (NSCs) and apoptosis in cells cultured in vitro. However, the underlying mechanisms responsible for these phenotypes in Ub-deficient cells have not been studied extensively. In the present study, we found that levels of repressor element-1 silencing transcription factor (REST) are elevated in Ubb(-/-) cells. To determine whether dysregulation of NSC differentiation is caused by the increased REST levels, we investigated the effect of reduced REST levels in Ubb(-/-) cells...
April 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28248981/interaction-between-body-mass-index-and-hormone-receptor-status-as-a-prognostic-factor-in-lymph-node-positive-breast-cancer
#20
Il Yong Chung, Jong Won Lee, Ji Sung Lee, Yu Rang Park, Yul Ha Min, Yura Lee, Tae In Yoon, Guiyun Sohn, Sae Byul Lee, Jisun Kim, Hee Jeong Kim, Beom Seok Ko, Byung Ho Son, Sei Hyun Ahn
The aim of this study was to determine the relationship between the body mass index (BMI) at a breast cancer diagnosis and various factors including the hormone-receptor, menopause, and lymph-node status, and identify if there is a specific patient subgroup for which the BMI has an effect on the breast cancer prognosis. We retrospectively analyzed the data of 8,742 patients with non-metastatic invasive breast cancer from the research database of Asan Medical Center. The overall survival (OS) and breast-cancer-specific survival (BCSS) outcomes were compared among BMI groups using the Kaplan-Meier method and Cox proportional-hazards regression models with an interaction term...
2017: PloS One
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