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https://www.readbyqxmd.com/read/28325888/factors-associated-with-clinical-outcomes-in-patients-with-primary-intraventricular-hemorrhage
#1
Sang-Hoon Lee, Kyung-Jae Park, Dong-Hyuk Park, Shin-Hyuk Kang, Jung-Yul Park, Yong-Gu Chung
BACKGROUND Primary intraventricular hemorrhage (PIVH) is an uncommon type of intracerebral hemorrhage. Owing to its rarity, the clinical and radiological factors affecting outcomes in patients with PIVH have not been widely studied. MATERIAL AND METHODS We retrospectively reviewed 112 patients (mean age 53 years) treated for PIVH at our institution from January 2004 to December 2014. Clinical and radiological parameters were analyzed 3 months after initial presentation to identify factors associated with clinical outcomes, as assessed by the Glasgow Outcome Scale (favorable ≥4, unfavorable <4)...
March 22, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28322349/an-aqueous-electrolyte-of-the-widest-potential-window-and-its-superior-capability-for-capacitors
#2
Hiroshi Tomiyasu, Hirokazu Shikata, Koichiro Takao, Noriko Asanuma, Seiichi Taruta, Yoon-Yul Park
A saturated aqueous solution of sodium perchlorate (SSPAS) was found to be electrochemically superior, because the potential window is remarkably wide to be approximately 3.2 V in terms of a cyclic voltammetry. Such a wide potential window has never been reported in any aqueous solutions, and this finding would be of historical significance for aqueous electrolyte to overcome its weak point that the potential window is narrow. In proof of this fact, the capability of SSPAS was examined for the electrolyte of capacitors...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28303807/efficacy-and-safety-of-newly-developed-cross-linked-dextran-gel-injection-for-glans-penis-augmentation-with-a-novel-technique
#3
Dae Yul Yang, Kyungtae Ko, Seong Ho Lee, Du Geon Moon, Jong Wook Kim, Won Ki Lee
There is no safe and effective standard method for glans penis augmentation. Furthermore, there has been scant research on glans penis augmentation due to a poor understanding of glans anatomy, technical difficulty, and a lack of suitable substances for augmentation. Cross-linked dextran gel is a newly developed filler for soft-tissue augmentation. We evaluated the efficacy and safety of using a novel technique to inject cross-linked dextran gel for glans penis augmentation during a 24-week follow-up study...
March 10, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28295626/mechanical-meibomian-gland-squeezing-combined-with-eyelid-scrubs-and-warm-compresses-for-the-treatment-of-meibomian-gland-dysfunction
#4
Hun Lee, Minseo Kim, Si Yoon Park, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
BACKGROUND: The aim was to investigate the efficacy of mechanical meibomian gland squeezing combined with eyelid scrubs and warm compresses in participants with moderate and severe meibomian gland dysfunction (MGD). METHODS: In this prospective, uncontrolled, open label, intervention study, 32 eyes of 32 participants with moderate and severe MGD were treated with mechanical squeezing of meibomian glands in combination with eyelid scrubs and warm compresses. We evaluated tear film break-up time (TBUT), corneal and conjunctival fluorescein staining scores, biomicroscopic examination of lid margins and meibomian glands, Ocular Surface Disease Index (OSDI) questionnaire and tear film lipid layer thickness determined via an interferometer before initiating treatment and after one month of treatment...
March 12, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28289646/effectiveness-of-ear-splint-therapy-for-ear-deformities
#5
Ji Eun Woo, Yul-Hyun Park, Eun Ji Park, Kyu Yong Park, Sun Hee Kim, Shin-Young Yim
OBJECTIVE: To present our experience with ear splint therapy for babies with ear deformities, and thereby demonstrate that this therapy is an effective and safe intervention without significant complications. METHODS: This was a retrospective study of 54 babies (35 boys and 19 girls; 80 ears; age ≤3 months) with ear deformities who had received ear splint therapy at the Center for Torticollis, Department of Physical Medicine and Rehabilitation, Ajou University Hospital between December 2014 and February 2016...
February 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28285139/regulation-of-rest-levels-overcomes-dysregulation-of-neural-stem-cell-differentiation-caused-by-disruption-of-polyubiquitin-gene-ubb
#6
Minji Kim, Kwon-Yul Ryu
Reduced levels of cellular ubiquitin (Ub) caused by disruption of the polyubiquitin gene Ubb lead to dysregulated differentiation of neural stem/progenitor cells (NSCs) and apoptosis in cells cultured in vitro. However, the underlying mechanisms responsible for these phenotypes in Ub-deficient cells have not been studied extensively. In the present study, we found that levels of repressor element-1 silencing transcription factor (REST) are elevated in Ubb(-/-) cells. To determine whether dysregulation of NSC differentiation is caused by the increased REST levels, we investigated the effect of reduced REST levels in Ubb(-/-) cells...
March 8, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28248981/interaction-between-body-mass-index-and-hormone-receptor-status-as-a-prognostic-factor-in-lymph-node-positive-breast-cancer
#7
Il Yong Chung, Jong Won Lee, Ji Sung Lee, Yu Rang Park, Yul Ha Min, Yura Lee, Tae In Yoon, Guiyun Sohn, Sae Byul Lee, Jisun Kim, Hee Jeong Kim, Beom Seok Ko, Byung Ho Son, Sei Hyun Ahn
The aim of this study was to determine the relationship between the body mass index (BMI) at a breast cancer diagnosis and various factors including the hormone-receptor, menopause, and lymph-node status, and identify if there is a specific patient subgroup for which the BMI has an effect on the breast cancer prognosis. We retrospectively analyzed the data of 8,742 patients with non-metastatic invasive breast cancer from the research database of Asan Medical Center. The overall survival (OS) and breast-cancer-specific survival (BCSS) outcomes were compared among BMI groups using the Kaplan-Meier method and Cox proportional-hazards regression models with an interaction term...
2017: PloS One
https://www.readbyqxmd.com/read/28237703/effect-of-cellular-ubiquitin-levels-on-the-regulation-of-oxidative-stress-response-and-proteasome-function-via-nrf1
#8
Donghee Lee, Kwon-Yul Ryu
The polyubiquitin genes Ubb and Ubc are upregulated under oxidative stress induced by arsenite [As(III)]. However, the role of ubiquitin (Ub) under As(III) exposure is not known in detail. In a previous study, we showed that the reduced viability observed in Ubc(-/-) mouse embryonic fibroblasts under As(III) exposure was not due to dysregulation of the Nrf2-Keap1 pathway, which prompted us to investigate another NFE2 family protein, nuclear factor erythroid 2-related factor 1 (Nrf1). In this study, we found that Ub deficiency due to Ubc knockdown in N2a cells reduced cell viability and proteasome activity under As(III) exposure...
April 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28230557/comparison-of-the-conventional-dresden-protocol-and-accelerated-protocol-with-higher-ultraviolet-intensity-in-corneal-collagen-cross-linking-for-keratoconus
#9
Moonjung Choi, Jiwon Kim, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
PURPOSE: To compare the accelerated corneal cross-linking (CXL) protocol and the conventional Dresden protocol in patients with keratoconus in terms of visual acuity, keratometric values, and topographic parameters. METHODS: Twenty-eight eyes of 25 patients with primary keratoconus were divided into 2 groups; 15 eyes in group 1 received CXL under the standard Dresden protocol (3 mW/cm for 30 min, dose 5.4 J/cm) and 13 eyes in group 2 were treated with the accelerated protocol (30 mW/cm for 3 min 40 s, dose 6...
February 22, 2017: Cornea
https://www.readbyqxmd.com/read/28222481/effect-of-diquafosol-three-per-cent-ophthalmic-solution-on-tear-film-and-corneal-aberrations-after-cataract-surgery
#10
Hun Lee, Sang Myung Kim, Seonghee Choi, Kyoung Yul Seo, Eung Kweon Kim, Tae-Im Kim
BACKGROUND: The aim was to evaluate the effect of diquafosol on tear film parameters and corneal aberrations after cataract surgery. METHODS: This retrospective, comparative, observational case series included patients who underwent cataract surgery with or without peri-operative use of diquafosol three per cent ophthalmic solution. Patients in group I (31 eyes) were treated with diquafosol three per cent ophthalmic solution six times a day from one week before surgery to three months after surgery...
February 21, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28199362/flowtaxis-of-osteoblast-migration-under-fluid-shear-and-the-effect-of-rhoa-kinase-silencing
#11
Brandon D Riehl, Jeong Soon Lee, Ligyeom Ha, Il Keun Kwon, Jung Yul Lim
Despite the important role of mechanical signals in bone remodeling, relatively little is known about how fluid shear affects osteoblastic cell migration behavior. Here we demonstrated that MC3T3-E1 osteoblast migration could be activated by physiologically-relevant levels of fluid shear in a shear stress-dependent manner. Interestingly, shear-sensitive osteoblast migration behavior was prominent only during the initial period after the onset of the steady flow (for about 30 min), exhibiting shear stress-dependent migration speed, displacement, arrest coefficient, and motility coefficient...
2017: PloS One
https://www.readbyqxmd.com/read/28195275/bond-strengths-of-orthodontic-metal-brackets-to-tribochemically-silica-coated-zirconia-surfaces-using-different-10-methacryloyloxydecyl-dihydrogen-phosphate-containing-primers
#12
Na-Hyun Kim, Yoon-Ji Kim, Dong-Yul Lee
PURPOSE: To evaluate the effects of tribochemical silica coating and different 10-methacryloyloxydecyl dihydrogen phosphate (MDP)-containing primers on the shear bond strength (SBS) of orthodontic metal brackets to yttrium-stabilized tetragonal zirconia polycrystal (Y-TZP) surfaces. MATERIALS AND METHODS: One hundred ninety polished Y-TZP specimens were randomly assigned to 19 groups (n = 10): 30 specimens were used for surface analyses after polishing with 600-grit silicon carbide paper, airborneparticle abrasion with 50-μm alumina (A), or tribochemical silica coating (CoJet [C]); 160 specimens were used in SBS testing of orthodontic metal brackets to Y-TZP after alumina airborne-particle abrasion or tribochemical silica coating and application of either ESPE-Sil (S) (ASn, ASa, CSn, CSa), Alloy Primer (AP) (AAPn, AAPa, CAPn, CAPa), Clearfil Ceramic Primer (CP) (ACPn, ACPa, CCPn, CCPa), or Scotchbond Universal (U) (AUn, AUa, CUn, CUa) and either stored in water for 24 h (non-aged, n) or thermocycled 5000 times (aged, a)...
February 10, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28191758/preclinical-analysis-of-fetal-human-mesencephalic-neural-progenitor-cell-lines-characterization-and-safety-in-vitro-and-in-vivo
#13
Jisook Moon, Sigrid C Schwarz, Hyun-Seob Lee, Jun Mo Kang, Young-Eun Lee, Bona Kim, Mi-Young Sung, Günter Höglinger, Florian Wegner, Jin Su Kim, Hyung-Min Chung, Sung Woon Chang, Kwang Yul Cha, Kwang-Soo Kim, Johannes Schwarz
We have developed a good manufacturing practice for long-term cultivation of fetal human midbrain-derived neural progenitor cells. The generation of human dopaminergic neurons may serve as a tool of either restorative cell therapies or cellular models, particularly as a reference for phenotyping region-specific human neural stem cell lines such as human embryonic stem cells and human inducible pluripotent stem cells. We cultivated 3 different midbrain neural progenitor lines at 10, 12, and 14 weeks of gestation for more than a year and characterized them in great detail, as well as in comparison with Lund mesencephalic cells...
February 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28187177/a-comparison-of-ki-67-counting-methods-in-luminal-breast-cancer-the-average-method-vs-the-hot-spot-method
#14
Min Hye Jang, Hyun Jung Kim, Yul Ri Chung, Yangkyu Lee, So Yeon Park
In spite of the usefulness of the Ki-67 labeling index (LI) as a prognostic and predictive marker in breast cancer, its clinical application remains limited due to variability in its measurement and the absence of a standard method of interpretation. This study was designed to compare the two methods of assessing Ki-67 LI: the average method vs. the hot spot method and thus to determine which method is more appropriate in predicting prognosis of luminal/HER2-negative breast cancers. Ki-67 LIs were calculated by direct counting of three representative areas of 493 luminal/HER2-negative breast cancers using the two methods...
2017: PloS One
https://www.readbyqxmd.com/read/28183148/ten-year-incidence-and-prevalence-of-clinically-diagnosed-blepharitis-in-south-korea-a-nationwide-population-based-cohort-study
#15
Tyler Hyungtaek Rim, Min Jae Kang, Moonjung Choi, Kyoung Yul Seo, Sung Soo Kim
IMPORTANCE: Blepharitis is one of the most common conditions. However, no study has yet evaluated the epidemiology by evaluating a large population-based sample. BACKGROUND: To evaluate the incidence and prevalence of clinically diagnosed blepharitis in South Korea. DESIGN: Nationwide population-based study. PARTICIPANTS: We investigated the Korean National Health Insurance Service-National Sample Cohort, a representative 1 million-sample of the Korean population, for patients diagnosed with blepharitis according to the Korean Classification of Diseases...
February 9, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28180980/myofibroblast-in-the-ligamentum-flavum-hypertrophic-activity
#16
Junseok W Hur, Taegeun Bae, Sunghyeok Ye, Joo-Hyun Kim, Sunhye Lee, Kyoungmi Kim, Seung-Hwan Lee, Jin-Soo Kim, Jang-Bo Lee, Tai-Hyoung Cho, Jung-Yul Park, Junho K Hur
PURPOSE: Majority of the previous studies compared lumbar spinal stenosis (LSS) and lumbar disc herniation (LDH) patients for analyses of LFH. However, the separation of normal/hypertrophied LF has often been ambiguous and the severity of hypertrophic activity differed. Here, we present a novel analysis scheme for LFH in which myofibroblast is proposed as a major etiological factor for LFH study. METHODS: Seventy-one LF patient tissue samples were used for this study...
February 8, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28132057/is-beta-blocker-use-beneficial-in-breast-cancer-a-meta-analysis
#17
Hyun Yul Kim, Youn Joo Jung, Sang Hyup Lee, Hyuk Jae Jung, Kyoungjune Pak
OBJECTIVE: Preclinical studies have proved that beta-blocking agents inhibit several pathways for breast cancer progression and metastasis. We aimed to evaluate the association between beta-blocker use and prognosis of breast cancer. METHODS: A systematic search for studies from MEDLINE and EMBASE (inception to March 2014) was performed using the keywords "breast cancer" and "beta-blocker." In 2 groups of breast cancer patients (beta-blocker users and non-beta-blocker users), overall deaths (ODs), cancer-specific deaths (CSDs), and recurrences were compared...
January 28, 2017: Oncology
https://www.readbyqxmd.com/read/28120565/parameters-of-glucose-and-lipid-metabolism-affect-the-occurrence-of-colorectal-adenomas-detected-by-surveillance-colonoscopies
#18
Nam Hee Kim, Jung Yul Suh, Jung Ho Park, Dong Il Park, Yong Kyun Cho, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
PURPOSE: Limited data are available regarding the associations between parameters of glucose and lipid metabolism and the occurrence of metachronous adenomas. We investigated whether these parameters affect the occurrence of adenomas detected on surveillance colonoscopy. MATERIALS AND METHODS: This longitudinal study was performed on 5289 subjects who underwent follow-up colonoscopy between 2012 and 2013 among 62171 asymptomatic subjects who underwent an initial colonoscopy for a health check-up between 2010 and 2011...
March 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28120559/the-effect-of-sex-and-anthropometry-on-clinical-outcomes-in-patients-undergoing-percutaneous-coronary-intervention-for-complex-coronary-lesions
#19
Seung Yul Lee, Dong Ho Shin, Jung Sun Kim, Byeong Keuk Kim, Young Guk Ko, Donghoon Choi, Yangsoo Jang, Myeong Ki Hong
PURPOSE: To evaluate the effects of sex and anthropometry on clinical outcomes in patients who underwent percutaneous coronary intervention (PCI). MATERIALS AND METHODS: From three randomized trials (REal Safety and Efficacy of 3-month dual antiplatelet Therapy following Endeavor zotarolimus-eluting stent implantation, Impact of intraVascular UltraSound guidance on outcomes of Xience Prime stents in Long lesions, Chronic Total Occlusion InterVention with drUg-eluting Stents), we compared 333 pairs of men and women matched by propensity scores, all of whom underwent intravascular ultrasound (IVUS)-guided PCI for complex lesions...
March 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28100913/genome-wide-association-study-using-the-ethnicity-specific-japonica-array-identification-of-new-susceptibility-loci-for-cold-medicine-related-stevens-johnson-syndrome-with-severe-ocular-complications
#20
Mayumi Ueta, Hiromi Sawai, Ryosei Shingaki, Yusuke Kawai, Chie Sotozono, Kaname Kojima, Kyung-Chul Yoon, Mee Kum Kim, Kyoung Yul Seo, Choun-Ki Joo, Masao Nagasaki, Shigeru Kinoshita, Katsushi Tokunaga
A genome-wide association study (GWAS) for cold medicine-related Stevens-Johnson syndrome (CM-SJS) with severe ocular complications (SOC) was performed in a Japanese population. A recently developed ethnicity-specific array with genome-wide imputation that was based on the whole-genome sequences of 1070 unrelated Japanese individuals was used. Validation analysis with additional samples from Japanese individuals and replication analysis using samples from Korean individuals identified two new susceptibility loci on chromosomes 15 and 16...
January 19, 2017: Journal of Human Genetics
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