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Sónia M M Faria, Graça Esgalhado, Cristina M G Pereira
Socioemotional learning (SEL) is the process of developing social and emotional competences through which the child learns to recognize and manage emotions, care for others, make good decisions, behave responsibly and ethically, develop positive relationships and avoid negative behaviours (Promoting social and emotional learning: Guidelines for educators, 1997). To promote the development of these competences, specific programmes are developed. This study aims to analyse the impact of a SEL programme among children with intellectual disability...
November 19, 2018: Journal of Applied Research in Intellectual Disabilities: JARID
Young Ae Kim, Hyunsoon Cho, Nayoung Lee, So-Youn Jung, Sung Hoon Sim, In Hae Park, Sunmi Lee, Eun Sook Lee, Hak Jin Kim
BACKGROUND: Doxorubicin is a typical anticancer drug that causes cardiomyopathy and heart failure (HF). The aim of our study was to investigate incidence, risk factors for doxorubicin-induced HF in Korean cancer patients and their survival rate, utilizing a nationwide population-based cohort. METHODS: We analyzed 58 541 cancer patients who received doxorubicin between 2003 and 2010. Descriptive analysis was performed in patients with breast cancer, hematologic malignancy, gynecological malignancy, and sarcoma...
November 19, 2018: Cancer Medicine
Leena Berlin Hallrup, Christine Kumlien, Elisabeth Carlson
BACKGROUND: People with intellectual disabilities in staffed group homes often need lifelong support and dependency on others. Thereby, special demands are placed on staff and service managers to ensure opportunities for participation in everyday life. This study aims to explore how service managers promote participation in Swedish group homes for adults with intellectual disabilities. METHOD: A qualitative research design involving individual interviews with 14 service managers was used to gain an understanding of how the participation of adults with intellectual disabilities can be promoted in Swedish group homes...
November 19, 2018: Journal of Applied Research in Intellectual Disabilities: JARID
Arthur Laquière, Christine Lefort, Frédérique Maire, Alain Aubert, Rodica Gincul, Frédéric Prat, Philippe Grandval, Olivier Croizet, James Boulant, Geoffroy Vanbiervliet, Guillaume Pénaranda, Laurence Lecomte, Bertrand Napoléon, Christian Boustière
BACKGROUND:  The aim of this prospective multicenter study was to compare a flexible 19 G needle with nitinol shaft (19 G Flex) with a standard 22 G needle for transduodenal endoscopic ultrasound (EUS)-guided sampling of pancreatic head tumors. METHODS:  Patients with pancreatic head tumors requiring tissue diagnosis were randomized into two arms: puncture with either a 19 G Flex needle or a 22 G needle. The primary end point was diagnostic accuracy for malignancy...
November 19, 2018: Endoscopy
Juliana Yang, Xianhui Zeng, Xianglei Yuan, Kenneth Chang, Omid Sanaei, Lea Fayad, Vivek Kumbhari, Vikesh Singh, Anthony N Kalloo, Bing Hu, Mouen A Khashab
BACKGROUND:  The aim of this study is to report a novel, multicenter experience with the diverticular peroral endoscopic myotomy (D-POEM) technique in the management of esophageal diverticula. METHODS:  This is a multicenter, international, retrospective study involving three centers. D-POEM was performed using the principles of submucosal endoscopy. RESULTS:  A total of 11 patients with an esophageal diverticulum (Zenker's 7, mid-esophagus 1, epiphrenic 3) were included...
November 19, 2018: Endoscopy
E Baudou, J Benevent, J L Montastruc, G Touati, C Hachon LeCamus
INTRODUCTION:  Valproic acid (VPA) is rarely used in neonatal period. In children under 2 years old, serious adverse effects are appear to be more frequent. AIM:  The aim of our study is to report the adverse effects observed in a population of full-term newborns treated with VPA. METHOD:  Full-term newborns, hospitalized at the Toulouse CHU, who presented with neonatal seizures and who received long-term treatment with VPA between 2004 and 2014 were included...
November 19, 2018: Neuropediatrics
Didem Ardıçlı, Goknur Haliloğlu, Mehmet Alikaşifoğlu, Haluk Topaloğlu
Up to 15% of Duchenne's muscular dystrophy (DMD) is caused by nonsense mutations (nm-DMD). In this study, we aimed to evaluate the age at diagnosis, presentations, and diagnostic approach in 43 nm-DMD boys. The mean age at presentation and diagnosis was 3 years and 4 years, respectively. Presenting signs or symptoms were asymptomatic creatine kinase (CK) elevation (40%), muscle weakness (30%), motor delay (18%), and walking difficulties (12%). Multiplex polymerase chain reaction (PCR) of the most commonly deleted exons were negative ( n  = 17), and muscle biopsy was consistent with dystrophinopathy ( n  = 24)...
November 19, 2018: Neuropediatrics
Aline Wolter, Marie Gebert, Christian Enzensberger, Andrea Kawecki, Rüdiger Stessig, Jan Degenhardt, Jochen Ritgen, Josef Thul, Markus Khalil, Johannes Herrmann, Roland Axt-Fliedner
PURPOSE:  The aim of our retrospective evaluation was to compare the outcome of patients with prenatal and postnatal diagnosis of Tetralogy of Fallot (TOF) and to analyze prenatal echocardiographic parameters predicting intervention within 30 days postnatal. MATERIALS AND METHODS:  We evaluated 142 patients in our pediatric heart center and prenatal diagnosis center and prenatal practice Praenatal plus in Cologne between 01/08 - 06/16. RESULTS:  Within the prenatal diagnosis group, 6/74 fetuses (8...
November 19, 2018: Ultraschall in der Medizin
Pelle Baggesgaard Petersen, Henrik Kehlet, Christoffer Calov Jørgensen
Most international guidelines recommend pharmacological thromboprophylaxis after total hip and knee arthroplasty (THA/TKA) for 10 to 35 days. However, a recent cohort study on fast-track THA and TKA questioned the need for prolonged thromboprophylaxis when length of stay (LOS) is ≤ 5 days. We aimed at re-investigating the incidence of venous thromboembolism (VTE) in fast-track THA and TKA with in-hospital only thromboprophylaxis when LOS was ≤ 5 days. Prospective cohort study from 1 December 2011 to 30 October 2015 on elective unilateral THA/TKA with in-hospital only thromboprophylaxis if LOS was ≤ 5 days...
November 19, 2018: Thrombosis and Haemostasis
Rahajeng N Tunjungputri, Yang Li, Philip G de Groot, Charles A Dinarello, Sanne P Smeekens, Martin Jaeger, Marije Doppenberg-Oosting, Milou Cruijsen, Heidi Lemmers, Helga Toenhake-Dijkstra, Raul Aguirre-Gamboa, Vinod Kumar, Cisca Wijmenga, Leo A B Joosten, Mihai G Netea, Andre van der Ven, Quirijn de Mast
BACKGROUND:  Inflammation and coagulation are key processes in cardiovascular diseases (CVDs). The Canakinumab Anti-inflammatory Thrombosis Outcome Study trial affirmed the importance of inflammation in CVD by showing that inhibition of the interleukin (IL)-1β pathway prevents recurrent CVD. A bi-directional relationship exists between inflammation and coagulation, but the precise interaction of platelets and IL-1β-mediated inflammation is incompletely understood. We aimed to determine the inter-relationship between platelets and inflammation-and especially IL-1β-in a cohort of healthy volunteers...
November 19, 2018: Thrombosis and Haemostasis
Joanna Sikora, Piotr Niezgoda, Malwina Barańska, Katarzyna Buszko, Natalia Skibińska, Wiktor Sroka, Krzysztof Pstrągowski, Jolanta Siller-Matula, Jilma Bernd, Diana Gorog, Eliano Pio Navarese, Michał Piotr Marszałł, Jacek Kubica
Extensive search for methods of overcoming morphine-related delay of the absorption and onset of action of oral P2Y12 inhibitors in patients presenting with acute coronary syndrome is on-going. The aim of the trial was to investigate whether metoclopramide co-administration could reduce this delay and improve the pharmacokinetics (PKs) and pharmacodynamics (PDs) of ticagrelor and its active metabolite AR-C124900XX. Plasma concentration of both compounds and platelet reactivity were evaluated in nine pre-defined time points within 6 hours after administration of ticagrelor loading dose...
November 19, 2018: Thrombosis and Haemostasis
I Soto-Rey, M Rehr, P Bruland, C Zeidler, C Riepe, S Steinke, S Ständer, M Dugas, M Storck
BACKGROUND:  Patient-reported outcomes (PROs) are information provided directly by patients that helps in improving patient diagnosis and treatment. Validated translations of PROs can be used to treat international patients. Electronic systems and especially mobile devices provide a great opportunity for their collection; however, these systems are normally study-oriented and therefore single language, not scalable, and not interoperable. OBJECTIVES:  This article reports the development of a multicenter, multilingual, and interoperable electronic PRO (ePRO) system and evaluates its user satisfaction in an international clinical study...
November 19, 2018: Methods of Information in Medicine
Sally K Gallena, Arthur T Johnson, Jafar Vossoughi
Purpose: The aim of the study was to develop a treatment for athletes with paradoxical vocal fold motion disorder (PVFMD) based on exercise physiology and learning theory principles and administer it over a preestablished time frame. Method: A prospective, repeated-measures, within-subject group design was used. Eleven adolescent/teen athletes diagnosed with PVFMD via laryngoscopy received short-term intensive (STI) therapy. Eight of the athletes returned for extended follow-up...
November 15, 2018: American Journal of Speech-language Pathology
Julie A Hengst, Melissa C Duff, Theresa A Jones
Purpose: Research manipulating the complexity of housing environments for healthy and brain-damaged animals has offered strong, well-replicated evidence for the positive impacts in animal models of enriched environments on neuroplasticity and behavioral outcomes across the lifespan. This article reviews foundational work on environmental enrichment from the animal literature and considers how it relates to a line of research examining rich communicative environments among adults with aphasia, amnesia, and related cognitive-communication disorders...
November 16, 2018: American Journal of Speech-language Pathology
Maria A Usik, Irina V Ogneva
BACKGROUND/AIMS: Changes in the external mechanical field result in cytoskeleton reorganization and the formation of adaptive patterns in different types of cells, including somatic cells and sex cells. The aim of this research was to study the protein and mRNA content of cytoskeletal and sperm-specific genes in the sperm and testis cells of mice. METHODS: Mice were subjected to 30 days of antiorthostatic suspension to simulate weightlessness, followed by 12 h of recovery, while receiving essential phospholipids at a dosage of 500 mg/kg/day (30HSE and 30HSE+12h groups) or a similar dosage of a placebo (30HS and 30HS+12h groups)...
November 19, 2018: Cellular Physiology and Biochemistry
Fangwei Li, Jian Wang, Yanting Zhu, Lu Liu, Wei Feng, Wenhua Shi, Qingting Wang, Qianqian Zhang, Limin Chai, Manxiang Li
BACKGROUND/AIMS: The underlying molecular mechanisms involved in sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate (S1P) mediation of platelet-derived growth factor (PDGF)-induced pulmonary arterial smooth muscle cell (PASMC) proliferation are still unclear, and the present study aims to address this issue. METHODS: Small interfering RNA (siRNA) and microRNA inhibitor transfection was performed to block the expression of SphK1, bone morphogenetic protein receptor II (BMPRII) and microRNA-21 (miR-21)...
November 19, 2018: Cellular Physiology and Biochemistry
Yang Wu, Tan Yuan, Wei-Wei Wang, Peng-Lei Ge, Zhi-Qiang Gao, Gong Zhang, Zhe Tang, Xiao-Wei Dang, Yong-Fu Zhao, Jian-Ying Zhang, Guo-Zhong Jiang
BACKGROUND/AIMS: This study aims to examine the effect of long noncoding RNA HOST2 (LncRNA HOST2) on epithelial-mesenchymal transition (EMT), proliferation, invasion and migration of hepatocellular carcinoma (HCC) cells via activation of the JAK2-STAT3 signaling pathway. METHODS: HCC and para-cancerous tissues were collected from 136 HCC patients. Immunohistochemistry was used to detect the expression of JAK2 and STAT3. HCC SMMC7721 cells were grouped into blank, negative control (NC), HOST2 mimic and HOST2 inhibitor groups...
November 19, 2018: Cellular Physiology and Biochemistry
Sophie Vandepitte, Koen Putman, Nele Van Den Noortgate, Sofie Verhaeghe, Eric Mormont, Lisa Van Wilder, Delphine De Smedt, Lieven Annemans
BACKGROUND/AIMS: Dementia is one of the main reasons for institutionalization among the elderly. Few studies have explored factors associated with the caregivers' (CG) desire to institutionalize (DTI) a person with dementia (PWD). The objective of this study is to identify modifiable and non-modifiable psychosocial and sociodemographic factors associated with a caregiver's DTI. METHODS: Cross-sectional data of 355 informal CG of community-dwelling PWD were analyzed...
November 19, 2018: Dementia and Geriatric Cognitive Disorders
Letícia Batista Azevedo Rangel, Daniel de Siqueira, Olívia do Rosário Soares, Higor Scardini Santana, Emílio de Castro Miguel, Maura da Cunha, Andre Lacerda de Abreu Oliveira, Diego França Pedrosa, Ludmilla Carvalho Rangel Resgala, Helder Azevedo Rangel Neto, Neuza Felix Gomes-Rochette, Sérgio Ragi Eis, Jones Bernardes Graceli, Ian Victor Silva
BACKGROUND/AIMS: Osteoporosis is a bone metabolic disease that affects mostly post-menopausal women. There has been shown that vitamin K (VK) supplementation during menopause may decrease bone loss as well as risk of bone breaking. Aiming to clarify the beneficial role of VK in bone metabolism during menopause, we investigated mineral metabolism and bone ultrastructure of ovariectomized (OVX) mice. METHODS: To determine the effects chronic use of VK in bone structure and mineral metabolism in OVX mice, we used several methods, such as DXA, µCTScan, and SEM as well as biomolecular techniques, such as ELISA and qRT-PCR...
November 19, 2018: Cellular Physiology and Biochemistry
Lynn Peters, Michael Soyka
OBJECTIVE: A growing number of studies indicate increased impulsivity in patients with opioid dependence (OD). However, few studies exclude concomitant drug use and consider depression as a comorbidity, both of which can bias results. AIM: We aimed to compare impulsivity in patients with OD enrolled in maintenance therapy (ICD code F11.22) and well-matched healthy controls taking psychopathological impairments into account. Furthermore, we compared the result to risky behavioral patterns in patients...
November 19, 2018: Neuropsychobiology
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