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Acceptable + reduction + pediatric

Marc J Weigensberg, Cheryl Vigen, Paola Sequeira, Donna Spruijt-Metz, Magaly Juarez, Daniella Florindez, Joseph Provisor, Anne Peters, Elizabeth A Pyatak
Background: The transition of young adults with type 1 diabetes (T1D) from pediatric to adult care is challenging and frequently accompanied by worsening of diabetes-related health. To date, there are no reports which prospectively assess the effects of theory-based psycho-behavioral interventions during the transition period neither on glycemic control nor on psychosocial factors that contribute to poor glycemic control. Therefore, the overall aim of this study was to develop and pilot test an integrative group intervention based on the underlying principles of self-determination theory (SDT), in young adults with T1D...
2018: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
Gian Mauro Manzoni, Alessandro Rossi, Nicoletta Marazzi, Fiorenza Agosti, Alessandra De Col, Giada Pietrabissa, Gianluca Castelnuovo, Enrico Molinari, Allessandro Sartorio
OBJECTIVE: This study was aimed to examine the feasibility, validity, and reliability of the Italian Pediatric Quality of Life Inventory Multidimensional Fatigue Scale (PedsQL™ MFS) for adult inpatients with severe obesity. METHODS: 200 inpatients (81% females) with severe obesity (BMI ≥ 35 kg/m2) completed the PedsQL MFS (General Fatigue, Sleep/Rest Fatigue and Cognitive Fatigue domains), the Fatigue Severity Scale, and the Center for Epidemiologic Studies Depression Scale immediately after admission to a 3-week residential body weight reduction program...
February 7, 2018: Obesity Facts
Sara Manti, Terri J Harford, Carmelo Salpietro, Fariba Rezaee, Giovanni Piedimonte
BACKGROUND: Despite decades have passed since its discovery, accurate biomarkers of Respiratory syncytial virus (RSV) disease activity and effective therapeutic strategies are still lacking. The high mobility group box type 1 (HMGB1) protein has been proposed as a possible link between RSV and immune system, but only limited information is currently available to support this hypothesis. METHODS: Expression of HMGB1 gene and protein were analyzed by quantitative PCR, ELISA, Western blot, immunocytochemistry, and confocal microscopy in immortalized and primary human bronchial epithelial cells, as well as in rat pup lungs...
January 12, 2018: Pediatric Research
Tova Hannegård Hamrin, Peter J Radell, Urban Fläring, Jonas Berner, Staffan Eksborg
The aim of the present study was to evaluate the performance of regional oxygen saturation (rSO2) monitoring with near infrared spectroscopy (NIRS) during pediatric inter-hospital transports and to optimize processing of the electronically stored data. Cerebral (rSO2-C) and abdominal (rSO2-A) NIRS sensors were used during transport in air ambulance and connecting ground ambulance. Data were electronically stored by the monitor during transport, extracted and analyzed off-line after the transport. After removal of all zero and floor effect values, the Savitzky-Golay algorithm of data smoothing was applied on the NIRS-signal...
December 28, 2017: Journal of Clinical Monitoring and Computing
Amisha Shah, Mitchell Rees, Erica Kar, Kimberly Bolton, Vincent Lee, Ashok Panigrahy
BACKGROUND: For the past several years, increased levels of imaging radiation and cumulative radiation to children has been a significant concern. Although several measures have been taken to reduce radiation dose during computed tomography (CT) scan, the newer dose reduction software adaptive statistical iterative reconstruction (ASIR) has been an effective technique in reducing radiation dose. To our knowledge, no studies are published that assess the effect of ASIR on extremity CT scans in children...
December 26, 2017: Skeletal Radiology
Anuradha V Khadilkar, Shashi A Chiplonkar, Neha A Kajale, Veena H Ekbote, Lavanya Parathasarathi, Raja Padidela, Vaman V Khadilkar
OBJECTIVE: To investigate inter-relationships of dietary-composition and physical activity (PA) with growth and BC in urban Indian school-children. METHODS: A cross-sectional study was performed in 4747-Indian school children (2623- Boys) aged 3-18 year. Weight, height, BC by body impedance analyser, PA and dietary food intakes by questionnaire method were recorded. RESULTS: Mean daily energy and protein intakes as Recommended Dietary Allowance (RDA) were significantly lower in both boys and girls (P<0...
December 20, 2017: Pediatric Research
Jonathan G Bensley, Lynette Moore, Robert De Matteo, Richard Harding, M Jane Black
BACKGROUND: Globally, approximately 10% of infants are born before full-term. Preterm birth exposes the heart to the demands of postnatal cardiovascular function before cardiac development is complete. Our aim was to examine, in hearts collected from infants at autopsy, the effects of preterm birth on myocardial structure and on cardiomyocyte development. METHODS AND RESULTS: Heart tissue was collected at perinatal autopsies of 16 infants who died following preterm birth between 23-36 weeks gestation, and survived for 1-42 days; the hearts of 37 appropriately grown stillborn infants, aged 20-40 weeks gestation, were used for comparison...
December 21, 2017: Pediatric Research
Kristina N Heye, Walter Knirsch, Beatrice Latal, Ianina Scheer, Kristina Wetterling, Andreas Hahn, Hakan Akintürk, Dietmar Schranz, Ingrid Beck, Ruth O Gorman Tuura, Bettina Reich
BackgroundLittle is known about the relationship between brain volumes and neurodevelopmental outcome at 2 years of age in children with single-ventricle congenital heart disease (CHD). We hypothesized that reduced brain volumes may be associated with adverse neurodevelopmental outcome.MethodsVolumetric segmentation of cerebral magnetic resonance imaging (MRI) scans was carried out in 44 patients without genetic comorbidities and in 8 controls. Neurodevelopmental outcome was assessed with the Bayley-III scales...
January 2018: Pediatric Research
Matthias Kreutz, Brigitte Fitze, Christoph Blecher, Augello Marcello, Ruben Simon, Rebecca Cremer, Hans-Florian Zeilhofer, Christoph Kunz, Johannes Mayr
PURPOSE: The recommendation issued by the American Academy of Pediatrics in the early 1990s to position infants on their back during sleep to prevent sudden infant death syndrome (SIDS) has dramatically reduced the number of deaths due to SIDS but has also markedly increased the prevalence of positional skull deformation in infants. Deformation of the base of the skull occurs predominantly in very severe deformational plagiocephaly and is accompanied by facial asymmetry, as well as an altered ear position, called ear shift...
January 2018: Journal of Cranio-maxillo-facial Surgery
Elizabeth D Allen, Kimberly Arcoleo, Courtney Rowe, William W Long
OBJECTIVE: Describe implementation and clinical impact of a "real world" School-Based Asthma Therapy (SBAT) Program serving an urban, largely Medicaid population in a large midwestern city in the United States. METHODS: A retrospective, descriptive evaluation of SBAT was conducted. Students were referred by school nurses or providers, enrolled throughout the year, and could reenroll in subsequent years. A total of 286 students participated in the 2015-2016 school year...
November 30, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
L Bosa, L Da Silva, D V Mendes, A Sifna, M Sargento Mendes, F Riccardi, R Colombatti
Background and objectives: The World Health Organization End tuberculosis (TB) Strategy, approved in 2014, aims at a 90% reduction in TB deaths and an 80% reduction in TB incidence rate by 2030. One of the suggested interventions is the systematic screening of people with suspected TB, belonging to specific risk groups. The Hospital Raoul Follereau (HRF) in Bissau, Guinea-Bissau, is the National Reference Hospital for Tuberculosis and Lung Disease of the country. We performed an active case-finding program among pediatric age family members and cohabitants of admitted adult TB patients, from January to December 2013...
2017: Mediterranean Journal of Hematology and Infectious Diseases
Jonathan P Dyke, Amanda C Garfinkel, Alan M Groves, Arzu Kovanlikaya
BACKGROUND: To evaluate a whole body rapid imaging technique to calculate neonatal lean body mass and percentage adiposity using 3.0 Tesla chemical shift Magnetic Resonance Imaging (MRI). METHODS: A 2-Point Dixon MRI technique was used to calculate whole body fat and water images in term (n=10) and preterm (n=15) infants. RESULTS: Chemical shift images were obtained in 42 s. MRI calculated whole body mass correlated closely with measured body weight (R(2)=0...
November 23, 2017: Pediatric Research
Yuanyuan Yan, Zhen Wang, Donghao Wang, Peter Lawrence, Xingguo Wang, Kumar S D Kothapalli, Jacelyn Greenwald, Ruijie Liu, Hui Gyu Park, J Thomas Brenna
BACKGROUND: Excess vernix caseosa produced by the fetal skin appears as particles suspended in the amniotic fluid in late gestation, is swallowed by the fetus and is found throughout the newborn GI tract as the first organisms are arriving to colonize the gut. Lipid rich vernix contains an unusually high 29% branched chain fatty acid (BCFA). BCFA reduce the incidence of necrotizing enterocolitis in an animal model, recently found predominantly in the sn-2 position of human milk triacylglycerols...
November 22, 2017: Pediatric Research
R Zamora-Mendoza, H Rosas-Vargas, M T Ramos-Cervantes, P Garcia-Zuniga, H Perez-Lorenzana, P Mendoza-Lorenzo, A C Perez-Ortiz, F J Estrada-Mena, A Miliar-Garcia, E Lara-Padilla, G Ceballos, A Rodriguez, F Villarreal, I Ramirez-Sanchez
BACKGROUND/OBJECTIVES: We aimed to evaluate mitochondrial biogenesis (MB), structure, metabolism and dysfunction in abdominal adipose tissue from male pediatric patients with obesity. SUBJECTS/METHODS: Samples were collected from five children with obesity (percentile ⩾95) and five eutrophic boys (percentile ⩾5/⩽85) (8-12 years old) following parental informed consent. We analyzed the expression of key genes involved in MB (sirtuin-1 (SIRT1), peroxisome proliferator-activated receptor-γ (PPARγ), PPARγ coactivator-1α (PGC1α), nuclear respiratory factors 1 and 2 (NRF1, NRF2) and mitochondrial transcription factor A (TFAM) and surrogates for mitochondrial function/structure/metabolism (porin, TOMM20, complex I and V, UCP1, UCP2, SIRT3, SOD2) by western blot...
November 21, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Martina Andellini, Sandra Fernandez Riesgo, Federica Morolli, Matteo Ritrovato, Piero Cosoli, Silverio Petruzzellis, Nicola Rosso
BACKGROUND: To test the application of Business Process Management technology to manage clinical pathways, using a pediatric kidney transplantation as case study, and to identify the benefits obtained from using this technology. METHODS: Using a Business Process Management platform, we implemented a specific application to manage the clinical pathway of pediatric patients, and monitored the activities of the coordinator in charge of the case management during a 6-month period (from June 2015 to November 2015) using two methodologies: the traditional procedure and the one under study...
November 3, 2017: BMC Medical Informatics and Decision Making
Valentin Mita, Michele Arigliani, Laura Zaratti, Raffaele Arigliani, Elisabetta Franco
Rotavirus (RV) infection is the main cause of severe acute gastroenteritis (GE) in the pediatric population and has a major impact in both developing and industrialized countries. The reduction of severe RVGE cases, followed by death or hospitalization, is considered the main benefit of RV vaccination, even though its implementation often faces obstacles. In Italy, the recently approved National Immunization Plan aims to overcome the differences among regions, offering a universal free RV vaccination. The aim of the study was to evaluate the opinions on benefit and acceptability of RV vaccination related to the perception of the burden of RV disease...
November 3, 2017: Pathogens
Robert M Joseph, Thomas M O'Shea, Elizabeth N Allred, Tim Heeren, Karl K Kuban
BackgroundTo determine if a key marker of socioeconomic status, maternal education, is associated with later neurocognitive and academic outcomes among children born extremely preterm (EP).MethodEight hundred and seventy-three children born at 23 to 27 weeks of gestation were assessed for cognitive and academic ability at age 10 years. With adjustments for gestational age (GA) and potential confounders, outcomes of children whose mothers had fewer years of education at the time of delivery and children whose mother advanced in education between birth and 10 years were examined...
November 22, 2017: Pediatric Research
Indrajit S Karande, Zoy Goff, Jacqueline Kewley, Shailender Mehta, Thomas Snelling
BACKGROUND: Antimicrobial doses in children are often prescribed by using an individually calculated dose per weight (e.g., mg/kg) or based on body surface area. Dosing errors are the most commonly reported medication errors in children. A "dose-banding" strategy is frequently used for some over-the-counter drugs to prevent dosing errors. It could also lead to efficiencies by enabling batch preparation of intravenous (IV) medications in hospitals. OBJECTIVES: To evaluate whether use of dose-banding for IV piperacillin-tazobactam results in acceptable dose variation from standard practice of individualized prescription of 100 mg/kg in children...
September 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
Aziz Eghbali, Shabnam Hajiani, Bahman Sadeghi Sedeh, Abdolghader Pakniyat, Vahid Mansouri, Bahador Bagheri
Hemangioma is a benign vascular tumor that shouldbe treated in problematic situations.Propranolol efficacy, target dose, range of age, duration of treatment and complications arenot conclusive for treatment of pediatric hemangioma. Our goal was to study efficacy and safety of propranolol for hemangioma treating in children. A randomized, open label crossover trial with two twenty four-week treatment phases separated by a one-week washout period, was conducted in Amir-Kabir Hospital, Arak, Iran. Thirty two patients with age of 1 month to 15 years were randomized to receive either oral propranolol 2 mg/Kg/day or receivedno treatment...
2017: Iranian Journal of Pharmaceutical Research: IJPR
Mônica Oliveira Bernardo, Fernando Antonio de Almeida, Flavio Morgado
OBJECTIVES: To analyze the results of an initiative aimed at improving the reasonable use of radiological examinations, ensuring their technical quality, implementing a radioprotection campaign that includes training of the professional team, and introducing the radioprotection card for children under 12 years old as a tool for parents and doctors to control children's exposure to radiation. METHODS: The study was held in a health care insurance system covering 140,000 people...
April 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
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