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https://www.readbyqxmd.com/read/28604755/physical-exercise-intervention-at-school-improved-hepcidin-inflammation-and-iron-metabolism-in-overweight-and-obese-children-and-adolescents
#1
Susana Coimbra, Cristina Catarino, Henrique Nascimento, Ana Inês Alves, Ana Filipa Medeiros, Elsa Bronze-da-Rocha, Elísio Costa, Petronila Rocha-Pereira, Luísa Aires, André Seabra, Jorge Mota, Helena Ferreira Mansilha, Carla Rêgo, Alice Santos-Silva, Luís Belo
BACKGROUND: Obesity is often associated with iron deficiency in children and adolescents. We aimed to study the effect of 8-month physical exercise (PE) intervention in hepcidin and other markers of inflammation and in iron status in overweight/obese children and adolescents. METHODS: Seventy-three overweight/obese children and adolescents participated in the 8-month longitudinal study; they were divided in two groups according to their participation in an after-school PE program: PE (n=44) and control (n=29) groups...
June 12, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28599334/-cyclodestructive-procedures-to-lower-intraocular-pressure-a-review
#2
Drazen Jurjevic, Jens Funk, Marc Töteberg-Harms
The only therapy for glaucoma, for which there is sufficient evidence, is the lowering of intraocular pressure. Intraocular pressure reduction can be achieved by an improvement in outflow or a reduction of aqueous humor production. Surgically, a reduction of aqueous humor production can be achieved by cyclodestructive procedures. This article provides a brief summary of the different cyclodestructive procedures. The efficacy of cyclophotocoagulation is well documented. The risk profile has been reduced by changes in the laser protocols...
June 9, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28594520/pediatric-metacarpal-fractures
#3
Jenna Godfrey, Roger Cornwall
Metacarpal fractures account for 10% to 35% of all pediatric hand fractures. Pediatric metacarpal fractures commonly occur in patients aged 13 to 16 years, with most injuries sustained during sports activities. Pseudoepiphyses can be confused with metacarpal fractures; however, a careful physical examination can help physicians distinguish the two. Thumb metacarpal base fractures that involve the physis warrant special attention. Thumb metacarpal base fractures with lateral metaphyseal fragments and pediatric Bennett fracture variants (Salter-Harris type III and type IV fractures) are unstable and require surgical management...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28574980/diagnostics-for-neonatal-sepsis-current-approaches-and-future-directions
#4
REVIEW
Pui-YingIroh Tam, Catherine M Bendel
Progress has been made in the reduction of morbidity and mortality from neonatal sepsis. However, diagnosis continues to rely primarily on conventional microbiologic techniques, which can be inaccurate. The objective of this review is to provide the clinician with an overview of the current information available on diagnosing this condition. We review currently available diagnostic approaches for documenting neonatal sepsis, and also describe novel approaches for diagnosing infection in neonates that are under development and investigation...
June 2, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28567283/dyslipidemia-management-in-overweight-or-obese-adolescents-a-mixed-methods-clinical-trial-of-motivational-interviewing
#5
Nita Chahal, Janet Rush, Cedric Manlhiot, Katherine M Boydell, Ahlexxi Jelen, Brian W McCrindle
BACKGROUND: Lifestyle management for dyslipidemic adolescents often occurs in the context of family-centered care, which necessitates adaptation of counseling strategies. OBJECTIVE: To determine the effectiveness of motivational interviewing for lifestyle behavior change for dyslipidemic adolescents in a dyad with a parent versus alone. METHODS: A total number of 32 adolescents were randomized 1:1 to receive a series of motivational interviewing sessions either together with a parent or alone for a 6-month intervention, with both quantitative and qualitative assessment of outcomes...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28493861/maternal-pre-pregnancy-obesity-and-neuropsychological-development-in-pre-school-children-a-prospective-cohort-study
#6
Maribel Casas, Joan Forns, David Martínez, Mònica Guxens, Ana Fernandez-Somoano, Jesus Ibarluzea, Nerea Lertxundi, Mario Murcia, Marisa Rebagliato, Adonina Tardon, Jordi Sunyer, Martine Vrijheid
BackgroundMaternal pre-pregnancy obesity may impair infant neuropsychological development, but it is unclear whether intrauterine or confounding factors drive this association.MethodsWe assessed whether maternal pre-pregnancy obesity was associated with neuropsychological development in 1,827 Spanish children. At 5 years, cognitive and psychomotor development was assessed using McCarthy Scales of Children's Abilities, attention deficit hyperactivity disorder (ADHD) symptoms using the Criteria of Diagnostic and Statistical Manual of Mental Disorders, and autism spectrum disorder symptoms using the Childhood Asperger Syndrome Test...
June 7, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28481642/micronutrient-therapy-for-violent-and-aggressive-male-youth-an-open-label-trial
#7
Jessica L Hambly, Kelly Francis, Sohil Khan, Kristen S Gibbons, William J Walsh, Brett Lambert, Chris Testa, Alison Haywood
OBJECTIVES: Pharmacotherapy for problematic aggressive and violent behavior disorders in male children and adolescents is associated with significant adverse events. Treatments with more acceptable risk-benefit ratios are critically needed. Micronutrient intervention will be investigated as an alternative to bridge the therapeutic gap in the management of these behaviors. METHODS: Males aged 4-14 who displayed ongoing violent and aggressive behaviors received micronutrient intervention containing alpha-tocopherol (vitamin E), ascorbic acid (vitamin C), biotin, chromium, pyridoxal-5-phosphate (P5P), pyridoxine (vitamins B6), selenium, and zinc, in a 16-week open-label trial...
May 8, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28473460/corneal-dose-reduction-using-a-bismuth-coated-latex-shield-over-the-eyes-during-brain-spect-ct
#8
Norikazu Matsutomo, Masaaki Fukunaga, Onishi Hideo, Tomoaki Yamamoto
Objective: This study aimed to determine whether a bismuth-coated latex shield (B-shield) could protect the eyes during brain SPECT/CT. Methods: A B-shield containing the heavy metal bismuth (0.15 mm lead equivalent) was placed over a cylindrical phantom and the eyes of a three-dimensional brain phantom filled with Tc-99m solution. Subsequently, phantoms with and without the B-shield were compared using SPECT/CT. The CT parameters were 30-200 mA and 130 kV. The dose reduction achieved by the B shield was measured using a pencil-shaped ionization chamber...
May 4, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28471070/performing-a-preliminary-hazard-analysis-applied-to-administration-of-injectable-drugs-to-infants
#9
Nadia Hfaiedh, Sofiane Kabiche, Catherine Delescluse, Issa-Bella Balde, Sophie Merlin, Sandra Carret, Loïc de Pontual, Jean-Eudes Fontan, Joël Schlatter
RATIONALE, AIMS AND OBJECTIVES: Errors in hospitals during the preparation and administration of intravenous drugs to infants and children have been reported to a rate of 13% to 84%. This study aimed to investigate the potential for hazardous events that may lead to an accident for preparation and administration of drug injection in a pediatric department and to describe a reduction plan of risks. METHODS: The preliminary hazard analysis (PHA) method was implemented by a multidisciplinary working group over a period of 5 months (April-August 2014) in infants aged from 28 days to 2 years...
May 4, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28436549/atrial-undersensing-secondary-to-quiet-timer-blanking-in-pediatric-and-congenital-heart-disease-patients
#10
Johannes C von Alvensleben, Michael Schaffer, Caitlin Brateng, Kathryn K Collins
BACKGROUND: Atrial undersensing despite normal atrial lead parameters and high amplitude electrograms has been described in adult patients as a consequence of atrial amplifier saturation. Repetitive inputs cause amplifier ringing and undersensing occurs as a consequence of quiet timer blanking. High amplitude ventricular electrograms can also result in atrial blanking secondary to cross-chamber effect. This has not been described in pediatric patients or epicardial pacing systems and specific risk factors are not known...
April 24, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28399118/feasibility-and-physiological-effects-of-non-invasive-neurally-adjusted-ventilatory-assist-niv-nava-in-preterm-infants
#11
Christopher Gibu, Phillip Cheng, Raymond J Ward, Benjamin Castro, Gregory P Heldt
BACKGROUND: Non-invasive Neurally Adjusted Ventilator Assist (NIV-NAVA) was introduced to our clinical practice via a pilot and a randomized observational study to assess its safety, feasibility, and short term physiological effects. METHODS: The pilot protocol applied NIV-NAVA to 11 infants on nasal CPAP, high-flow nasal cannula (HFNC), or nasal IMV (NIMV), in multiple 2-4 h periods of NIV-NAVA for comparison. This provided the necessary data to design a randomized, controlled observational cross-over study in 8 additional infants to compare the physiological effects of NIV-NAVA to NIMV during 2-hour steady state conditions...
April 11, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28376078/the-expression-of-renin-angiotensin-aldosterone-axis-components-in-infantile-hemangioma-tissue-and-the-impact-of-propranolol-treatment
#12
James R Dornhoffer, Ting Wei, Haihong Zhang, Emily Miller, Mario A Cleves, Gresham T Richter
BackgroundPropranolol's mechanism of action for controlling infantile hemangioma (IH) remains unclear. We hypothesize that this nonselective beta antagonist downregulates renin-angiotensin-aldosterone (RAA) axis components, preventing angiogenic substrate induction of IH.MethodsIH tissue and serum were collected from children with propranolol-treated or -untreated IH during surgery. Normal skin and serum from demographically matched children were used as controls. Real-time PCR and western blot quantified RAA components in proliferative (n=10), involuting (n=10), propranolol-treated (n=12) IH, and normal specimens (n=11)...
May 3, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28365895/does-proton-therapy-have-a-future-in-cns-tumors
#13
REVIEW
Stephanie E Combs
Proton therapy is characterized by certain physical properties leading to a reduction in integral dose. As proton therapy becomes more widely available, the ongoing discussion on the real indications for proton therapy becomes more important. In the present article, data on proton therapy for tumors of the central nervous system (CNS) is summarized and discussed in view of modern photon treatments. Still today, no randomized controlled trials are available confirming any clinical benefit of protons in CNS tumors...
March 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28355205/interaction-of-maternal-caffeine-intake-during-pregnancy-and-cyp1a2-c164a-polymorphism-affects-infant-birth-size-in-the-hokkaido-study
#14
Seiko Sasaki, Mariko Limpar, Fumihiro Sata, Sumitaka Kobayashi, Reiko Kishi
BACKGROUND: Caffeine, 1,3,7-trimethylxanthine, is widely consumed by women of reproductive age. Although caffeine has been proposed to inhibit fetal growth, previous studies on the effects of caffeine on infant birth size have yielded inconsistent findings. This variability may result from failure to account for individual differences in caffeine metabolism related to polymorphisms in the gene for CYP1A2, the major caffeine-metabolizing enzyme. METHODS: Five hundred fourteen Japanese women participated in a prospective cohort study in Sapporo, Japan from 2002 to 2005 and 476 mother-child pairs were included for final analysis...
March 29, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28347608/sedation-effects-of-intranasal-dexmedetomidine-delivered-as-sprays-versus-drops-on-pediatric-response-to-venous-cannulation
#15
Zhubin Xie, Weihua Shen, Jingyi Lin, Liwen Xiao, Minyan Liao, Xiaoliang Gan
OBJECTIVES: Mucosal atomization device (MAD) was designed to increase the bioavailability of intranasal medications by facilitating absorption, the present study aimed to evaluate and compare the sedation effects of intranasal dexmedetomidine delivered as drops versus sprays on pediatric responses to intravenous cannulation. METHODS: One hundred and six pediatric patients (aged from 2 to 5years) scheduled for elective ophthalmic surgery were intranasally received a dose of 2μg/kg in 20μl/kg of dexmedetomidine for sedation to reduce response to venous cannulation...
March 18, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28345547/contrast-dose-and-radiation-dose-reduction-in-abdominal-enhanced-computerized-tomography-scans-with-single-phase-dual-energy-spectral-computerized-tomography-mode-for-children-with-solid-tumors
#16
Tong Yu, Jun Gao, Zhi-Min Liu, Qi-Feng Zhang, Yong Liu, Ling Jiang, Yun Peng
BACKGROUND: Contrast dose and radiation dose reduction in computerized tomography (CT) scan for adult has been explored successfully, but there have been few studies on the application of low-concentration contrast in pediatric abdominal CT examinations. This was a feasibility study on the use of dual-energy spectral imaging and adaptive statistical iterative reconstruction (ASiR) for the reduction of radiation dose and iodine contrast dose in pediatric abdominal CT patients with solid tumors...
April 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28277262/eliminating-blood-culture-false-positives-harnessing-the-power-of-nursing-shared-governance
#17
Dawn Moeller
Our emergency department struggled with unacceptable blood culture contamination rates for several years. The objective of this project was to create a self-governing culture within nursing that would generate and sustain the achievement of monthly blood culture contamination rates below the national benchmark of 3% and the hospital laboratory acceptable threshold of 2.3%. METHODS: The ED shared governance council partnered with the laboratory team to review the monthly epidemiology reports for all adult and pediatric ED patients having blood cultures performed from January 2010 through December 2015...
October 26, 2016: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/28271087/comparison-of-pediatric-and-general-orthopedic-surgeons-approaches-in-management-of-developmental-dysplasia-of-the-hip-and-flexible-flatfoot-the-road-to-clinical-consensus
#18
Ramin Haj Zargarbashi, Hirbod Nasiri Bonaki, Shayan Abdollah Zadegan, Taghi Baghdadi, Mohammad Hossein Nabian, Mehdi Ramezan Shirazi
Developmental dysplasia of the hip (DDH) and flatfoot are common pediatric orthopedic disorders, being referred to and managed by both general and pediatric orthopedic surgeons, through various modalities. Our study aimed to evaluate their consensus and perspective disagreements in terms of diagnostic and therapeutic approaches of the mentioned deformities. Forty participants in two groups of general orthopedic surgeons (GOS) (n=20) and pediatric orthopedic surgeons (POS) (n=20), were asked to answer an 8-item questionnaire on DDH and flexible flatfoot...
January 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28270279/feasibility-of-pediatric-chest-ct-using-spectral-filtration-on-third-generation-dual-source-ct
#19
Wei Liu, Jingjuan Liu, Huadan Xue, Xin Sui, Wei Song, Kai Xu, Weilin Wan, Zhenghong Li, Zhengyu Jin
Objective To prospectively investigate the radiation dose and image quality of pediatric chest CT using Sn100 kV on a third-generation dual-source CT (DSCT)in comparison to standard 100 kV chest CT. Methods From December 12,2015 to June 30,2016,45 consecutive pediatric patients referred for non-contrast chest CT scan in Peking Union Medical College Hospital were prospectively enrolled as study group. They were examined at 100 kV with a dedicated tin filter on a third-generation DSCT. These patients were retrospectively matched with 45 patients who were examined on a second-generation DSCT at 100 kV without tin filter...
February 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28251116/pediatric-hepatitis-b-treatment
#20
REVIEW
Haruki Komatsu, Ayano Inui, Tomoo Fujisawa
Although the introduction of hepatitis B vaccine has been contributing to the reduction in the prevalence of hepatitis B virus (HBV) carriers worldwide, the treatment of children with chronic HBV infection is a challenge to be addressed. HBeAg seroconversion, which induces low replication of HBV, is widely accepted as the first goal of antiviral treatment in children with chronic hepatitis B. However, spontaneous HBeAg seroconversion is highly expected in children with chronic HBV infection. Therefore, the identification of children who need antiviral treatment to induce HBeAg seroconversion is essential in the management of chronic HBV infection...
February 2017: Annals of Translational Medicine
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