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https://www.readbyqxmd.com/read/29166379/bcfa-enriched-vernix-monoacylglycerol-reduces-lps-induced-inflammatory-markers-in-human-enterocytes-in-vitro
#1
Yuanyuan Yan, Zhen Wang, Donghao Wang, Peter Lawrence, Xingguo Wang, Kumar S D Kothapalli, Jacelyn Greenwald, Ruijie Liu, Hui Gyu Park, J Thomas Brenna
BACKGROUND: Excess vernix caseosa produced by the fetal skin appears as particles suspended in the amniotic fluid in late gestation, is swallowed by the fetus and is found throughout the newborn GI tract as the first organisms are arriving to colonize the gut. Lipid rich vernix contains an unusually high 29% branched chain fatty acid (BCFA). BCFA reduce the incidence of necrotizing enterocolitis in an animal model, recently found predominantly in the sn-2 position of human milk triacylglycerols...
November 22, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29158541/dysregulation-of-mitochondrial-function-and-biogenesis-modulators-in-adipose-tissue-of-obese-children
#2
R Zamora-Mendoza, H Rosas-Vargas, M T Ramos-Cervantes, P Garcia-Zuniga, H Perez-Lorenzana, P Mendoza-Lorenzo, A Perez-Ortiz, J Estrada, A Miliar-Garcia, E Lara-Padilla, G Ceballos, A Rodriguez, F Villarreal, I Ramirez-Sanchez
BACKGROUND/OBJECTIVES: We aimed to evaluate mitochondrial biogenesis (MB), structure, metabolism, and dysfunction in abdominal adipose tissue from male pediatric patients with obesity. SUBJECTS/METHODS: Samples were collected from five children with obesity (percentile ⩾95) and five eutrophic boys (percentile ⩾5/⩽85) (8-12 years old) following parental informed consent. We analyzed the expression of key genes involved in MB (SIRT1, PPARγ, PGC1α, NRF1, NRF2, and TFAM) and surrogates for mitochondrial function/structure/metabolism (porin, TOMM20, complex I and V, UCP1, UCP2, SIRT3, SOD2) by Western blot...
November 21, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29100512/experimental-application-of-business-process-management-technology-to-manage-clinical-pathways-a-pediatric-kidney-transplantation-follow-up-case
#3
Martina Andellini, Sandra Fernandez Riesgo, Federica Morolli, Matteo Ritrovato, Piero Cosoli, Silverio Petruzzellis, Nicola Rosso
BACKGROUND: To test the application of Business Process Management technology to manage clinical pathways, using a pediatric kidney transplantation as case study, and to identify the benefits obtained from using this technology. METHODS: Using a Business Process Management platform, we implemented a specific application to manage the clinical pathway of pediatric patients, and monitored the activities of the coordinator in charge of the case management during a 6-month period (from June 2015 to November 2015) using two methodologies: the traditional procedure and the one under study...
November 3, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29099756/italian-physicians-opinions-on-rotavirus-vaccine-implementation
#4
Valentin Mita, Michele Arigliani, Laura Zaratti, Raffaele Arigliani, Elisabetta Franco
Rotavirus (RV) infection is the main cause of severe acute gastroenteritis (GE) in the pediatric population and has a major impact in both developing and industrialized countries. The reduction of severe RVGE cases, followed by death or hospitalization, is considered the main benefit of RV vaccination, even though its implementation often faces obstacles. In Italy, the recently approved National Immunization Plan aims to overcome the differences among regions, offering a universal free RV vaccination. The aim of the study was to evaluate the opinions on benefit and acceptability of RV vaccination related to the perception of the burden of RV disease...
November 3, 2017: Pathogens
https://www.readbyqxmd.com/read/29072866/maternal-educational-status-at-birth-maternal-educational-advancement-and-neurocognitive-outcomes-at-age-10-years-among-children-born-extremely-preterm
#5
Robert M Joseph, Thomas M O'Shea, Elizabeth N Allred, Tim Heeren, Karl K Kuban
OBJECTIVE: To determine if a key marker of socioeconomic status (SES), maternal education, is associated with later neurocognitive and academic outcomes among children born extremely preterm (EP). METHOD: 873 children born at 23 to 27 weeks of gestation were assessed for cognitive and academic ability at age 10 years. With adjustments for gestational age (GA) and potential confounders, outcomes of children whose mothers had fewer years of education at the time of delivery and children whose mother advanced in education between birth and 10 years were examined...
October 26, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29042838/dose-banding-of-intravenous-piperacillin-tazobactam-in-pediatric-surgical-inpatients
#6
Indrajit S Karande, Zoy Goff, Jacqueline Kewley, Shailender Mehta, Thomas Snelling
BACKGROUND: Antimicrobial doses in children are often prescribed by using an individually calculated dose per weight (e.g., mg/kg) or based on body surface area. Dosing errors are the most commonly reported medication errors in children. A "dose-banding" strategy is frequently used for some over-the-counter drugs to prevent dosing errors. It could also lead to efficiencies by enabling batch preparation of intravenous (IV) medications in hospitals. OBJECTIVES: To evaluate whether use of dose-banding for IV piperacillin-tazobactam results in acceptable dose variation from standard practice of individualized prescription of 100 mg/kg in children...
September 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28979336/a-24-week-treatment-of-pediatric-hemangioma-with-oral-propranolol
#7
Aziz Eghbali, Shabnam Hajiani, Bahman Sadeghi Sedeh, Abdolghader Pakniyat, Vahid Mansouri, Bahador Bagheri
Hemangioma is a benign vascular tumor that shouldbe treated in problematic situations.Propranolol efficacy, target dose, range of age, duration of treatment and complications arenot conclusive for treatment of pediatric hemangioma. Our goal was to study efficacy and safety of propranolol for hemangioma treating in children. A randomized, open label crossover trial with two twenty four-week treatment phases separated by a one-week washout period, was conducted in Amir-Kabir Hospital, Arak, Iran. Thirty two patients with age of 1 month to 15 years were randomized to receive either oral propranolol 2 mg/Kg/day or receivedno treatment...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28977335/radioprotection-campaign-and-card-educational-strategies-that-reduce-children-s-excessive-exposure-to-radiological-exams
#8
Mônica Oliveira Bernardo, Fernando Antonio de Almeida, Flavio Morgado
OBJECTIVES: To analyze the results of an initiative aimed at improving the reasonable use of radiological examinations, ensuring their technical quality, implementing a radioprotection campaign that includes training of the professional team, and introducing the radioprotection card for children under 12 years old as a tool for parents and doctors to control children's exposure to radiation. METHODS: The study was held in a health care insurance system covering 140,000 people...
April 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/28906315/development-of-the-aim-to-decrease-anxiety-and-pain-treatment-adapt-for-pediatric-functional-abdominal-pain-disorders
#9
Natoshia Raishevich Cunningham, Sarah Nelson, Anjana Jagpal, Erin Moorman, Michael Farrell, Scott Pentiuk, Susmita Kashikar-Zuck
OBJECTIVES: To evaluate the feasibility and acceptability of the Aim to Decrease Anxiety and Pain Treatment (ADAPT), a brief, on-line and in-person behavioral intervention targeting pain and anxiety in youth with functional abdominal pain disorders (FAPD). METHODS: Patients were recruited from several outpatient pediatric gastroenterology clinics. Nine participants (ages 9-13) completed the full protocol. Thematic analysis of detailed qualitative feedback was obtained via semi-structured patient and caregiver interviews after treatment was conducted...
September 12, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28902088/obesity-increases-risk-of-loss-of-reduction-after-casting-for-diaphyseal-fractures-of-the-radius-and-ulna-in-children-an-observational-cohort-study
#10
Christopher J DeFrancesco, Benjamin H Rogers, Apurva S Shah
OBJECTIVES: To determine if high body mass index (BMI) increases the risk of loss of reduction (LOR) following closed reduction and casting for displaced concomitant fractures of the radial and ulnar shafts in pediatric patients. DESIGN: Retrospective cohort study SETTING:: A single tertiary care, urban children's hospital PATIENTS/PARTICIPANTS:: Pediatric patients aged 2-18 years with closed, displaced, concomitant diaphyseal fractures of the radius and ulna (AO/OTA 22-A3) who underwent closed reduction and casting at the study site...
August 26, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28868627/hydroxyurea-prescription-availability-and-use-for-children-with-sickle-cell-disease-in-italy-results-of-a-national-multicenter-survey
#11
Raffaella Colombatti, Giovanni Palazzi, Nicoletta Masera, Lucia Dora Notarangelo, Elisa Bonetti, Piera Samperi, Angelica Barone, Silverio Perrotta, Elena Facchini, Maurizio Miano, Giovanni Carlo Del Vecchio, Maria Elena Guerzoni, Paola Corti, Federica Menzato, Simone Cesaro, Maddalena Casale, Paolo Rigano, Gian Luca Forni, Giovanna Russo, Laura Sainati
BACKGROUND: The number of patients with sickle cell disease (SCD) has increased in Italy in the past decade due to immigration. In spite of the established efficacy of hydroxyurea (HU) in childhood, population-based data regarding its prescription and effectiveness come mainly from studies performed in adults or outside Europe. POPULATION AND METHODS: The Hydroxyurea in SCD: A Large Nation-wide Cohort Study from Italy was a retrospective cohort study of adult and pediatric patients with SCD attending 32 centers...
September 4, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28865661/methods-to-assess-adverse-childhood-experiences-of-children-and-families-toward-approaches-to-promote-child-well-being-in-policy-and-practice
#12
Christina D Bethell, Adam Carle, James Hudziak, Narangerel Gombojav, Kathleen Powers, Roy Wade, Paula Braveman
BACKGROUND: Advances in human development sciences point to tremendous possibilities to promote healthy child development and well-being across life by proactively supporting safe, stable and nurturing family relationships (SSNRs), teaching resilience, and intervening early to promote healing the trauma and stress associated with disruptions in SSNRs. Assessing potential disruptions in SSNRs, such as adverse childhood experiences (ACEs), can contribute to assessing risk for trauma and chronic and toxic stress...
September 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28844419/pediatric-elbow-arthroscopy-indications-and-safety
#13
Steven M Andelman, Kristen M Meier, Amanda L Walsh, Joung Heon Kim, Michael R Hausman
BACKGROUND: Elbow arthroscopy is a minimally invasive means by which to treat a variety of acute and chronic elbow conditions. Although the safety and efficacy is well documented in the adult population, comparatively little information is available about the role of elbow arthroscopy in the pediatric population. This study reports the indications for and safety of elbow arthroscopy in a series of pediatric patients. METHODS: A retrospective review was performed from 2001 to 2015 of a surgical database at a single institution...
August 22, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28830927/physical-activity-counseling-for-children-with-cystic-fibrosis
#14
Fiona J Moola, Eric Garcia, Elizabeth Huynh, Lauren Henry, Shannon Penfound, Raquel Consunji-Araneta, Guy E J Faulkner
BACKGROUND: Physical activity is recommended as a component of the cystic fibrosis (CF) treatment regimen. However, to date, there is limited research examining the effects of behavioral counseling interventions aimed at increasing physical activity. The aim of this study was to assess the feasibility of a theoretically informed, parent-mediated counseling intervention in increasing habitual physical activity and quality of life among children and youth with CF. METHODS: Participants were recruited from the pediatric respirology clinic at the Children's Hospital of Winnipeg...
August 22, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28814444/implementing-an-inpatient-pediatric-prospective-audit-and-feedback-antimicrobial-stewardship-program-within-a-larger-medical-center
#15
Jennifer Lighter-Fisher, Sonya Desai, Anna Stachel, Vinh Philip Pham, Liana Klejmont, Yanina Dubrovskaya
BACKGROUND: Pediatric antimicrobial stewardship programs (ASPs) within larger institutions have unique opportunities to develop programs specialized to the needs of the pediatric program. In January 2013, our institution established a formalized pediatric ASP utilizing the prospective audit and feedback process. In an effort to standardize therapy and improve quality of care, members of the ASP developed evidence-based guidelines for management of common inpatient pediatric infections...
September 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28771784/a-qualitative-study-of-decision-making-on-phase-iii-randomized-clinical-trial-participation-in-pediatric-oncology-adolescents-and-parents-perspectives-and-preferences
#16
Marianne Vie Ingersgaard, Morten Tulstrup, Kjeld Schmiegelow, Hanne Baekgaard Larsen
AIM: To explore parents' and adolescents' motives for accepting/declining participation in the ALL2008 trials and adolescents' involvement in the decision-making process. BACKGROUND: Children and adolescents with acute lymphoblastic leukemia treated on the Nordic Society of Paediatric Haematology and Oncology ALL2008 protocol were eligible for two randomizations testing 6-mercaptopurine treatment intensifications to improve efficacy and Asparaginase de-escalation to reduce toxicity...
August 3, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28738028/ebv-hlh-children-with-reductions-in-cd4-t-cells-and-excessive-activation-of-cd8-t-cells
#17
Cheng Yang, Xiujuan Zhu, Ting Zhang, Qing Ye
BackgroundIn this report, we analyzed the number and activation profiles of T cells in Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) patients and assessed their value for the diagnosis of EBV-HLH.MethodsWe compared the quantity of CD4+ T cells and CD8+ T cells in peripheral blood among HLH patients, a sepsis group, and healthy controls. We then analyzed variations in the activation marker in CD4+ T and CD8+ T cells.ResultsThe percentage of CD4+ T cells decreased in the EBV-HLH patients when compared with healthy controls, which induced significant differences in the ratio of CD4+ T cells/CD8+ T cells...
December 2017: Pediatric Research
https://www.readbyqxmd.com/read/28728766/assessment-of-safe-sleep-validation-of-the-parent-newborn-sleep-safety-survey
#18
Leanne Whiteside-Mansell, Rosemary Nabaweesi, Alison Rose Caballero, Samantha Hope Mullins, Beverly Kaye Miller, Mary Elizabeth Aitken
PURPOSE: Sudden Infant Death Syndrome (SIDS) and suffocation account for more than half of all Sudden Unexpected Infant Deaths (SUID). The American Academy of Pediatrics (AAP) recommendations describe the safest environments to protect infants. This study compared parent responses on the Newborn Sleep Safety Survey and observational assessments (N=72) of infant sleep environments in families thought to be at high-risk for non-compliance with AAP recommendations. DESIGN AND METHODS: A naturalistic study of participants enrolled in two home visitation support programs was used...
July 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28727927/technology-components-as-adjuncts-to-family-based-pediatric-obesity-treatment-in-low-income-minority-youth
#19
Gina L Tripicchio, Alice S Ammerman, Cody Neshteruk, Myles S Faith, Kelsey Dean, Christie Befort, Dianne S Ward, Kimberly P Truesdale, Kyle S Burger, Ann Davis
BACKGROUND: Strategies to treat pediatric obesity are needed, especially among high-need populations. Technology is an innovative approach; however, data on technology as adjuncts to in-person treatment programs are limited. METHODS: A total of 64 children [body mass index (BMI) ≥85th percentile, mean age = 9.6 ± 3.1 years, 32.8% female, 84.4% Hispanic] were recruited to participate in one of three cohorts of a family-based behavioral group (FBBG) treatment program: FBBG only, TECH1, and TECH2...
July 20, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28723887/in-vitro-and-in-vivo-characterization-of-poractant-alfa-supplemented-with-budesonide-for-safe-and-effective-intratracheal-administration
#20
Francesca Ricci, Chiara Catozzi, Francesca Ravanetti, Xabier Murgia, Francesco D'Aló, Natalia Macchidani, Elisa Sgarbi, Valentina Di Lallo, Federica Saccani, Marisa Pertile, Antonio Cacchioli, Silvia Catinella, Gino Villetti, Maurizio Civelli, Francesco Amadei, Fabio Franco Stellari, Barbara Pioselli, Fabrizio Salomone
BackgroundThe intratracheal (IT) administration of budesonide using surfactant as a vehicle has been shown to reduce the incidence of bronchopulmonary dysplasia (BPD) in preterm infants. The objective of this study was to characterize the in vitro characteristics and in vivo safety and efficacy of the extemporaneous combination of budesonide and poractant alfa.MethodsThe stability, minimum surface tension, and viscosity of the preparation were evaluated by means of high-performance liquid chromatography (HPLC), Wilhelmy balance, and Rheometer, respectively...
December 2017: Pediatric Research
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